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Ali Akalin MD, PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentPathology
AddressUMass Chan Medical School
One Innovation Drive Biotech Three
Worcester MA 01605
Phone508-793-6152
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentPathology
    DivisionAnatomic Pathology


    Collapse Biography 
    Collapse education and training
    Ankara University, Ankara, , TurkeyMD
    Virginia Commonwealth University, Richmond, VA, United StatesPHDExperimental Pathology

    Collapse Overview 
    Collapse overview

    Board Certification

    - American Board of Pathology

    - Anatomic and Clinical Pathology, 2005

    - Cytopathology, 2007

    Education

    1992 M.D.

    Ankara University, School of Medicine, Ankara, Turkey

    2000 Ph.D.

    Virginia Commonwealth University, School of Medicine, Richmond, VA

    Residency/Fellowships

    2001-2005

    Resident in Anatomic and Clinical Pathology, University of Colorado, School of Medicine, Denver, Colorado

    2005-2006

    Fellow in Surgical Pathology, University of Colorado, School of Medicine, Denver, Colorado

    2006-2007

    Fellow in Cytopathology, University of Massachusetts, School of Medicine, Worcester, MA

    Academic Appointments

    2007 – present

    Assistant Professor, Department of Pathology, University ofMassachusetts, Worcester, MA

    Clinical Appointments

    2007- present

    Staff Pathologist, Department of Pathology, University of Massachusetts, Worcester, MA

    2010- present

    Director of Head & NeckPathology, Department ofPathology, University of Massachusetts, Worcester, MA

    Honors Awards and Grants

    1999

    Association of Molecular Pathology Trainee Award, Missouri


    Research Interests :Dr. Akalin's Picture

    Dr. Akalin has broad diagnostic expertise, with interests in head & neck pathology, cytopathology, and pulmonary pathology. He participates in teaching fellows and residents in our department.

    His research interests include:

    - Study of new techniques to improve the diagnostic yield in fine needle aspirations.

    - Specific detection of cervical cancers using cytometry-based molecular diagnostics.

    - Development of radiolabeled biomarkers for the localization of neoplasms.

    - Exploration of new diagnostic and prognostic markers in pulmonary disorders with a focus on lung neoplasms.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rackard F, Huang X, Saha D, Akalin A, Watts G, Most M. Large Osteolipoma of the Posterior Ankle: A Rare Tumor in an Unusual Location. J Am Podiatr Med Assoc. 2025 Jan-Feb; 115(1). PMID: 40126985.
      Citations:    
    2. Babu S, Horowitz M, Delgado-Coka LA, Roa-Pe?a L, Akalin A, Escobar-Hoyos LF, Shroyer KR. Keratin 17 and A2ML1 are negative prognostic biomarkers in non-small cell lung cancer. Pathol Res Pract. 2024 Nov; 263:155643. PMID: 39413460.
      Citations:    
    3. Karpinski P, Mendez-Pena JE, Wu CL, Akalin A, Cornejo KM, Hung YP, Hoang MP. POU4F3 Is a Sensitive and Specific Marker of Merkel Cell Carcinoma. Mod Pathol. 2025 Jan; 38(1):100627. PMID: 39341281.
      Citations:    
    4. Zezoff D, Lowas S, Cleary M, Akalin A, Riaz F, Gauguet JM. Radiologic findings of an adolescent epithelioid inflammatory myofibroblastic sarcoma. Radiol Case Rep. 2024 Dec; 19(12):6199-6204. PMID: 39376959.
      Citations:    
    5. Delgado-Coka LA, Roa-Pe?a L, Babu S, Horowitz M, Petricoin EF, Matrisian LM, Blais EM, Marchenko N, Allard FD, Akalin A, Jiang W, Larson BK, Hendifar AE, Picozzi VJ, Choi M, Shroyer KR, Escobar-Hoyos LF. Keratin 17 is a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma. Am J Clin Pathol. 2024 Sep 03; 162(3):314-326. PMID: 38642081.
      Citations:    
    6. Jang J, Kim YH, Westgate B, Zong Y, Hallinan C, Akalin A, Lee K. Author Correction: Screening adequacy of unstained thyroid fine needle aspiration samples using a deep learning-based classifier. Sci Rep. 2023 Sep 12; 13(1):15065. PMID: 37699955.
      Citations:    Fields:    
    7. Fallon K, Akalin A, Wu P, Remenschneider AK. Primary Sarcoidosis of the Temporal Bone a Clinical Pathologic Correlation. Otol Neurotol Open. 2023 Sep; 3(3):e039. PMID: 38515640.
      Citations:    
    8. Lee CK, Oliveira LVN, Akalin A, Specht CA, Lourenco D, Gomez CL, Ramirez-Ortiz ZG, Wang JP, Levitz SM. Dysregulated pulmonary inflammatory responses exacerbate the outcome of secondary aspergillosis following influenza. mBio. 2023 Oct 31; 14(5):e0163323. PMID: 37681974.
      Citations:    Fields:    Translation:HumansAnimals
    9. Jang J, Kim YH, Westgate B, Zong Y, Hallinan C, Akalin A, Lee K. Screening adequacy of unstained thyroid fine needle aspiration samples using a deep learning-based classifier. Sci Rep. 2023 08 19; 13(1):13525. PMID: 37598279.
      Citations:    Fields:    Translation:Humans
    10. Lee CK, Oliveira LVN, Akalin A, Specht CA, Lourenco D, Gomez CL, Ramirez-Ortiz ZG, Wang JP, Levitz SM. Dysregulated Pulmonary Inflammatory Responses Exacerbate the Outcome of Secondary Aspergillosis Following Influenza. bioRxiv. 2023 Jun 30. PMID: 37425745.
      Citations:    
    11. Patil T, Dickson KM, Viera M, Bludevich BM, Akalin A, Uy K, Lou F, Maxfield MW. COVID-19-induced Esophageal Necrosis Requiring Emergent Total Esophagectomy in a Vaccinated Patient. Am Surg. 2023 Nov; 89(11):4999-5001. PMID: 37295021.
      Citations:    Fields:    Translation:Humans
    12. Palleiko BA, Lim CJ, Dickson KM, Bludevich BM, Bai S, Akalin A, Maxfield MW, Uy K, Lou F. Extra-axial Chordoma of the Sternoclavicular Joint. Ann Thorac Surg Short Rep. 2023 Mar; 1(1):131-133. PMID: 39790525.
      Citations:    
    13. Liao H, Sheridan T, Cosar E, Owens C, Zuo T, Wang X, Akalin A, Kandil D, Dresser K, Fogarty K, Bellve K, Baer C, Fischer A. Deconvolution microscopy: A platform for rapid on-site evaluation of fine needle aspiration specimens that enables recovery of the sample. Cytopathology. 2022 05; 33(3):312-320. PMID: 35102620.
      Citations: 1     Fields:    Translation:Humans
    14. Xu X, Zhang J, Filion TM, Akalin A, Song J. Modulating Mechanical and Shape-Memory Properties while Mitigating Degradation-Induced Inflammation of Polylactides by Pendant Aspirin Incorporation. ACS Appl Mater Interfaces. 2021 May 19; 13(19):22271-22281. PMID: 33956420.
      Citations:    Fields:    Translation:AnimalsCells
    15. Haye K, Babu S, Oblein L, Gupta R, Akalin A, Escobar-Hoyos LF, Shroyer KR. Keratin 17 Expression Predicts Poor Clinical Outcome in Patients With Advanced Esophageal Squamous Cell Carcinoma. Appl Immunohistochem Mol Morphol. 2021 02 01; 29(2):144-151. PMID: 32554975.
      Citations: 3     Fields:    Translation:Humans
    16. Sun T, Akalin A, Dresser K, Fischer AH, Zuo T. The Utility of MYB Immunohistochemistry (IHC) in Fine Needle Aspiration (FNA) Diagnosis of Adenoid Cystic Carcinoma (AdCC). Head Neck Pathol. 2021 Jun; 15(2):389-394. PMID: 32661670.
      Citations: 3     Fields:    Translation:Humans
    17. Roychowdhury P, Akalin A, Ito CJ. Dieulafoy's Lesion of the Nasal Mucosa: A Case of Recurrent Epistaxis From Submucosal Arterial Malformation. OTO Open. 2020 Apr-Jun; 4(2):2473974X20927001. PMID: 32548542.
      Citations:    
    18. Bai JDK, Babu S, Roa-Pe?a L, Hou W, Akalin A, Escobar-Hoyos LF, Shroyer KR. Keratin 17 is a negative prognostic biomarker in high-grade endometrial carcinomas. Hum Pathol. 2019 12; 94:40-50. PMID: 31655172.
      Citations:    
    19. Piper AJ, Clark JL, Mercado-Matos J, Matthew-Onabanjo AN, Hsieh CC, Akalin A, Shaw LM. Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC). PLoS One. 2019; 14(8):e0220567. PMID: 31393907.
      Citations: 14     Fields:    Translation:Humans
    20. Roa-Pe?a L, Leiton CV, Babu S, Pan CH, Vanner EA, Akalin A, Bandovic J, Moffitt RA, Shroyer KR, Escobar-Hoyos LF. Keratin 17 identifies the most lethal molecular subtype of pancreatic cancer. Sci Rep. 2019 08 02; 9(1):11239. PMID: 31375762.
      Citations: 31     Fields:    Translation:Humans
    21. Huang L, Touray S, Akalin A, Ahmad S. A 54-Year-Old Man Presenting With Progressive Dyspnea and Interstitial Lung Abnormalities. Chest. 2019 03; 155(3):e69-e74. PMID: 30846077.
      Citations:    Fields:    Translation:Humans
    22. Akalin A, Ergin A, Remiszewski S, Mu X, Raz D, Diem M. Resolving Interobserver Discrepancies in Lung Cancer Diagnoses by Spectral Histopathology. Arch Pathol Lab Med. 2019 02; 143(2):157-173. PMID: 30141697.
      Citations: 3     Fields:    Translation:Humans
    23. Specht CA, Lee CK, Huang H, Hester MM, Liu J, Luckie BA, Torres Santana MA, Mirza Z, Khoshkenar P, Abraham A, Shen ZT, Lodge JK, Akalin A, Homan J, Ostroff GR, Levitz SM. Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species. mBio. 2017 11 28; 8(6). PMID: 29184017.
      Citations: 39     Fields:    Translation:AnimalsCells
    24. Mockler D, Escobar-Hoyos LF, Akalin A, Romeiser J, Shroyer AL, Shroyer KR. Keratin 17 Is a Prognostic Biomarker in Endocervical Glandular Neoplasia. Am J Clin Pathol. 2017 Sep 01; 148(3):264-273. PMID: 28821199.
      Citations: 18     Fields:    Translation:Humans
    25. Guerra ES, Lee CK, Specht CA, Yadav B, Huang H, Akalin A, Huh JR, Mueller C, Levitz SM. Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma. PLoS Pathog. 2017 01; 13(1):e1006175. PMID: 28095479.
      Citations: 44     Fields:    Translation:AnimalsCells
    26. Diem M, Ergin A, Remiszewski S, Mu X, Akalin A, Raz D. Infrared micro-spectroscopy of human tissue: principles and future promises. Faraday Discuss. 2016 06 23; 187:9-42. PMID: 27075634.
      Citations: 8     Fields:    Translation:Humans
    27. Nielsen N, Akalin A, Sirkis HM, Most MJ. Multifocal Langerhans Cell Histiocytosis in an Adult. Am J Orthop (Belle Mead NJ). 2015 Dec; 44(12):563-8. PMID: 26665244.
      Citations:    Fields:    Translation:Humans
    28. Akalin A, Mu X, Kon MA, Ergin A, Remiszewski SH, Thompson CM, Raz DJ, Diem M. Classification of malignant and benign tumors of the lung by infrared spectral histopathology (SHP). Lab Invest. 2015 Jun; 95(6):697. PMID: 26012705.
      Citations: 4     Fields:    
    29. Mu X, Kon M, Ergin A, Remiszewski S, Akalin A, Thompson CM, Diem M. Statistical analysis of a lung cancer spectral histopathology (SHP) data set. Analyst. 2015 Apr 07; 140(7):2449-64. PMID: 25664623.
      Citations: 9     Fields:    Translation:Humans
    30. Akalin A, Mu X, Kon MA, Ergin A, Remiszewski SH, Thompson CM, Raz DJ, Diem M, Bird B, Miljkovic M. Classification of malignant and benign tumors of the lung by infrared spectral histopathology (SHP). Lab Invest. 2015 Apr; 95(4):406-21. PMID: 25664390.
      Citations: 11     Fields:    Translation:Humans
    31. Walavalkar V, Patwardhan RV, Owens CL, Lithgow M, Wang X, Akalin A, Nompleggi DJ, Zivny J, Wassef W, Marshall C, Levey J, Walter O, Fischer AH. Utility of liquid-based cytologic examination of distal esophageal brushings in the management of Barrett esophagus: a prospective study of 45 cases. J Am Soc Cytopathol. 2015 May - Jun; 4(3):113-121. PMID: 31051691.
      Citations:    Fields:    
    32. Tsyrkunou AV, Ellison RT, Akalin A, Wiederhold N, Sutton DA, Lindner J, Fan H, Levitz SM, Zivna I. Multifocal Rhizopus microsporus lung infection following brush clearing. Med Mycol Case Rep. 2014 Oct; 6:14-7. PMID: 25379391.
      Citations:    
    33. Parnes AN, Akalin A, Quinlan RM, Vijayaraghavan GR. AIRP best cases in radiologic-pathologic correlation: lactating adenoma. Radiographics. 2013 Mar-Apr; 33(2):455-9. PMID: 23479707.
      Citations: 6     Fields:    Translation:Humans
    34. Cornejo KM, Shi M, Akalin A, Uy K, Cagle PT, Fraire AE. Pulmonary papillary adenoma: a case report and review of the literature. J Bronchology Interv Pulmonol. 2013 Jan; 20(1):52-7. PMID: 23328145.
      Citations: 6     Fields:    Translation:Humans
    35. Bird B, Miljkovic MS, Remiszewski S, Akalin A, Kon M, Diem M. Infrared spectral histopathology (SHP): a novel diagnostic tool for the accurate classification of lung cancer. Lab Invest. 2012 Sep; 92(9):1358-73. PMID: 22751349.
      Citations: 34     Fields:    Translation:Humans
    36. Liu X, Cheng D, Gray BD, Wang Y, Akalin A, Rusckowski M, Pak KY, Hnatowich DJ. Radiolabeled Zn-DPA as a potential infection imaging agent. Nucl Med Biol. 2012 Jul; 39(5):709-14. PMID: 22321532.
      Citations: 10     Fields:    Translation:AnimalsCells
    37. Liu G, Dou S, Akalin A, Rusckowski M, Streeter PR, Shultz LD, Greiner DL. Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol. 2012 Jul; 39(5):645-51. PMID: 22316614.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    38. Wang JP, Lee CK, Akalin A, Finberg RW, Levitz SM. Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans. PLoS One. 2011; 6(10):e26232. PMID: 22039448.
      Citations: 27     Fields:    Translation:Animals
    39. Singh M, Darcy KM, Brady WE, Clubwala R, Weber Z, Rittenbach JV, Akalin A, Whitney CW, Zaino R, Ramirez NC, Leslie KK. Cadherins, catenins and cell cycle regulators: impact on survival in a Gynecologic Oncology Group phase II endometrial cancer trial. Gynecol Oncol. 2011 Nov; 123(2):320-8. PMID: 21813170.
      Citations: 16     Fields:    Translation:HumansCTClinical Trials
    40. Liu G, Dou S, Baker S, Akalin A, Cheng D, Chen L, Rusckowski M, Hnatowich DJ. A preclinical 188Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49. Cancer Biol Ther. 2010 Oct 15; 10(8):767-74. PMID: 21099368.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    41. Liu X, Wang Y, Nakamura K, Kawauchi S, Akalin A, Cheng D, Chen L, Rusckowski M, Hnatowich DJ. Auger radiation-induced, antisense-mediated cytotoxicity of tumor cells using a 3-component streptavidin-delivery nanoparticle with 111In. J Nucl Med. 2009 Apr; 50(4):582-90. PMID: 19289423.
      Citations: 7     Fields:    Translation:AnimalsCells
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