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Last Name

Ali Akalin MD, PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
AddressUniversity of Massachusetts Medical School
One Innovation Drive, Biotech Three
Worcester MA 01605
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    Other Positions
    InstitutionUMMS - School of Medicine
    DivisionAnatomic Pathology

    Collapse Biography 
    Collapse education and training
    Ankara University, Ankara, , TurkeyMD
    Virginia Commonwealth University, Richmond, VA, United StatesPHDExperimental Pathology

    Collapse Overview 
    Collapse overview

    Board Certification

    - American Board of Pathology

    - Anatomic and Clinical Pathology, 2005

    - Cytopathology, 2007


    1992 M.D.

    Ankara University, School of Medicine, Ankara, Turkey

    2000 Ph.D.

    Virginia Commonwealth University, School of Medicine, Richmond, VA



    Resident in Anatomic and Clinical Pathology, University of Colorado, School of Medicine, Denver, Colorado


    Fellow in Surgical Pathology, University of Colorado, School of Medicine, Denver, Colorado


    Fellow in Cytopathology, University of Massachusetts, School of Medicine, Worcester, MA

    Academic Appointments

    2007 – present

    Assistant Professor, Department of Pathology, University ofMassachusetts, Worcester, MA

    Clinical Appointments

    2007- present

    Staff Pathologist, Department of Pathology, University of Massachusetts, Worcester, MA

    2010- present

    Director of Head & NeckPathology, Department ofPathology, University of Massachusetts, Worcester, MA

    Honors Awards and Grants


    Association of Molecular Pathology Trainee Award, Missouri

    Research Interests :Dr. Akalin's Picture

    Dr. Akalin has broad diagnostic expertise, with interests in head & neck pathology, cytopathology, and pulmonary pathology. He participates in teaching fellows and residents in our department.

    His research interests include:

    - Study of new techniques to improve the diagnostic yield in fine needle aspirations.

    - Specific detection of cervical cancers using cytometry-based molecular diagnostics.

    - Development of radiolabeled biomarkers for the localization of neoplasms.

    - Exploration of new diagnostic and prognostic markers in pulmonary disorders with a focus on lung neoplasms.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Xu X, Zhang J, Filion TM, Akalin A, Song J. Modulating Mechanical and Shape-Memory Properties while Mitigating Degradation-Induced Inflammation of Polylactides by Pendant Aspirin Incorporation. ACS Appl Mater Interfaces. 2021 May 06. PMID: 33956420.
      View in: PubMed
    2. Sun T, Akalin A, Dresser K, Fischer AH, Zuo T. The Utility of MYB Immunohistochemistry (IHC) in Fine Needle Aspiration (FNA) Diagnosis of Adenoid Cystic Carcinoma (AdCC). Head Neck Pathol. 2020 Jul 13. PMID: 32661670.
      View in: PubMed
    3. Roychowdhury P, Akalin A, Ito CJ. Dieulafoy's Lesion of the Nasal Mucosa: A Case of Recurrent Epistaxis From Submucosal Arterial Malformation. OTO Open. 2020 Apr-Jun; 4(2):2473974X20927001. PMID: 32548542.
      View in: PubMed
    4. Piper AJ, Clark JL, Mercado-Matos J, Matthew-Onabanjo AN, Hsieh CC, Akalin A, Shaw LM. Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC). PLoS One. 2019; 14(8):e0220567. PMID: 31393907.
      View in: PubMed
    5. Huang L, Touray S, Akalin A, Ahmad S. A 54-Year-Old Man Presenting With Progressive Dyspnea and Interstitial Lung Abnormalities. Chest. 2019 Mar; 155(3):e69-e74. PMID: 30846077.
      View in: PubMed
    6. Akalin A, Ergin A, Remiszewski S, Mu X, Raz D, Diem M. Resolving Interobserver Discrepancies in Lung Cancer Diagnoses by Spectral Histopathology. Arch Pathol Lab Med. 2018 Aug 24. PMID: 30141697.
      View in: PubMed
    7. Specht CA, Lee CK, Huang H, Hester MM, Liu J, Luckie BA, Torres Santana MA, Mirza Z, Khoshkenar P, Abraham A, Shen ZT, Lodge JK, Akalin A, Homan J, Ostroff GR, Levitz SM. Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species. MBio. 2017 Nov 28; 8(6). PMID: 29184017.
      View in: PubMed
    8. Guerra ES, Lee CK, Specht CA, Yadav B, Huang H, Akalin A, Huh JR, Mueller C, Levitz SM. Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma. PLoS Pathog. 2017 Jan 17; 13(1):e1006175. PMID: 28095479.
      View in: PubMed
    9. Diem M, Ergin A, Remiszewski S, Mu X, Akalin A, Raz D. Infrared micro-spectroscopy of human tissue: principles and future promises. Faraday Discuss. 2016 Jun 23; 187:9-42. PMID: 27075634.
      View in: PubMed
    10. Akalin A, Mu X, Kon MA, Ergin A, Remiszewski SH, Thompson CM, Raz DJ, Diem M. Classification of malignant and benign tumors of the lung by infrared spectral histopathology (SHP). Lab Invest. 2015 Jun; 95(6):697. PMID: 26012705.
      View in: PubMed
    11. Mu X, Kon M, Ergin A, Remiszewski S, Akalin A, Thompson CM, Diem M. Statistical analysis of a lung cancer spectral histopathology (SHP) data set. Analyst. 2015 Apr 7; 140(7):2449-64. PMID: 25664623.
      View in: PubMed
    12. Akalin A, Mu X, Kon MA, Ergin A, Remiszewski SH, Thompson CM, Raz DJ, Diem M, Bird B, Miljkovic M. Classification of malignant and benign tumors of the lung by infrared spectral histopathology (SHP). Lab Invest. 2015 Apr; 95(4):406-21. PMID: 25664390.
      View in: PubMed
    13. Walavalkar V, Patwardhan RV, Owens CL, Lithgow M, Wang X, Akalin A, Nompleggi DJ, Zivny J, Wassef W, Marshall C, Levey J, Walter O, Fischer AH. Utility of liquid-based cytologic examination of distal esophageal brushings in the management of Barrett esophagus: a prospective study of 45 cases. J Am Soc Cytopathol. 2015 May - Jun; 4(3):113-121. PMID: 31051691.
      View in: PubMed
    14. Tsyrkunou AV, Ellison RT, Akalin A, Wiederhold N, Sutton DA, Lindner J, Fan H, Levitz SM, Zivna I. Multifocal Rhizopus microsporus lung infection following brush clearing. Med Mycol Case Rep. 2014 Oct; 6:14-7. PMID: 25379391.
      View in: PubMed
    15. Parnes AN, Akalin A, Quinlan RM, Vijayaraghavan GR. AIRP best cases in radiologic-pathologic correlation: lactating adenoma. Radiographics. 2013 Mar-Apr; 33(2):455-9. PMID: 23479707.
      View in: PubMed
    16. Cornejo KM, Shi M, Akalin A, Uy K, Cagle PT, Fraire AE. Pulmonary papillary adenoma: a case report and review of the literature. J Bronchology Interv Pulmonol. 2013 Jan; 20(1):52-7. PMID: 23328145.
      View in: PubMed
    17. Bird B, Miljkovic MS, Remiszewski S, Akalin A, Kon M, Diem M. Infrared spectral histopathology (SHP): a novel diagnostic tool for the accurate classification of lung cancer. Lab Invest. 2012 Sep; 92(9):1358-73. PMID: 22751349.
      View in: PubMed
    18. Liu G, Dou S, Akalin A, Rusckowski M, Streeter PR, Shultz LD, Greiner DL. Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol. 2012 Jul; 39(5):645-51. PMID: 22316614.
      View in: PubMed
    19. Liu X, Cheng D, Gray BD, Wang Y, Akalin A, Rusckowski M, Pak KY, Hnatowich DJ. Radiolabeled Zn-DPA as a potential infection imaging agent. Nucl Med Biol. 2012 Jul; 39(5):709-14. PMID: 22321532.
      View in: PubMed
    20. Wang JP, Lee CK, Akalin A, Finberg RW, Levitz SM. Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans. PLoS One. 2011; 6(10):e26232. PMID: 22039448.
      View in: PubMed
    21. Liu G, Dou S, Baker S, Akalin A, Cheng D, Chen L, Rusckowski M, Hnatowich DJ. A preclinical 188Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49. Cancer Biol Ther. 2010 Oct 15; 10(8):767-74. PMID: 21099368.
      View in: PubMed
    22. Liu X, Wang Y, Nakamura K, Kawauchi S, Akalin A, Cheng D, Chen L, Rusckowski M, Hnatowich DJ. Auger radiation-induced, antisense-mediated cytotoxicity of tumor cells using a 3-component streptavidin-delivery nanoparticle with 111In. J Nucl Med. 2009 Apr; 50(4):582-90. PMID: 19289423.
      View in: PubMed
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