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Carolina Ionete MD, PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentNeurology
AddressUMass Memorial Medical Center
119 Belmont Street
Worcester MA 01605
Phone508-793-6559
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeurology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program


    Collapse Biography 
    Collapse education and training
    Carol Davila University of Medicine and Pharmacy, Bucharest, , RomaniaMD
    Carol Davila University of Medicine and Pharmacy, Bucharest, , RomaniaPHDMedicine

    Collapse Overview 
    Collapse Summary
    Dr. Ionete is a clinical neuroimmunologist and educator with special interests including clinical trials in multiple sclerosis and other autoimmune neurological diseases, and neurological complications of HIV infections. She chairs the Department of Neurology's education committee.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Col NF, Solomon AJ, Alvarez E, Pbert L, Ionete C, Morales IB, Chester J, Kutz C, Iwuchukwu C, Livingston T, Springmann V, Col H, Ngo L. Shared decision-making for multiple sclerosis using the MS-SUPPORT tool: a plain language summary. Neurodegener Dis Manag. 2025 Apr-Jun; 15(2-3):97-106. PMID: 40329687.
      Citations:    
    2. Oh J, Arnold DL, Cree BAC, Ionete C, Kim HJ, Sormani MP, Syed S, Chen Y, Maxwell CR, Benoit P, Turner TJ, Wallstroem E, Wiendl H. Tolebrutinib versus Teriflunomide in Relapsing Multiple Sclerosis. N Engl J Med. 2025 May 15; 392(19):1893-1904. PMID: 40202623.
      Citations:    
    3. Houtchens MK, Manieri MC, Mahlanza TD, Pol-Patil J, Klawiter EC, Solomon AJ, Lathi E, Katz J, Ionete C, Morales IB, Severson C, Zurawski J, Stankiewicz JM, Cabot A, Sadovnick AD. A Real-World Prospective Multiple Sclerosis Pregnancy Registry in the United States: PREG-MS. Neurol Clin Pract. 2025 Apr; 15(2):e200425. PMID: 39810912.
      Citations:    
    4. Rabin A, Bello E, Kumar S, Zeki DA, Afshari K, Deshpande M, Francis N, Khalighinejad F, Umeton R, Radu I, Qutab F, Kwong D, Kurban M, Hemond C, Richmond JM, Ionete C. Targeted proteomics of cerebrospinal fluid in treatment na?ve multiple sclerosis patients identifies immune biomarkers of clinical phenotypes. Sci Rep. 2024 09 18; 14(1):21793. PMID: 39294186.
      Citations:    
    5. Hemond CC, Dundamadappa SK, Deshpande M, Baek J, Brown RH, Ionete C, Reich DS. Paramagnetic Rim Lesions are Highly Specific for Multiple Sclerosis in Real-World Data. medRxiv. 2024 Aug 15. PMID: 39371137.
      Citations:    
    6. Herranz E, Treaba CA, Barletta VT, Mehndiratta A, Ouellette R, Sloane JA, Ionete C, Babu S, Mastantuono M, Magon S, Loggia ML, Makary MM, Hooker JM, Catana C, Kinkel RP, Nicholas R, Klawiter EC, Magliozzi R, Mainero C. Characterization of cortico-meningeal translocator protein expression in multiple sclerosis. Brain. 2024 Jul 05; 147(7):2566-2578. PMID: 38289855.
      Citations:    Fields:    
    7. Cross AH, Gelfand JM, Thebault S, Bennett JL, von B?dingen HC, Cameron B, Carruthers R, Edwards K, Fallis R, Gerstein R, Giacomini PS, Greenberg B, Hafler DA, Ionete C, Kaunzner UW, Kodama L, Lock C, Longbrake EE, Musch B, Pardo G, Piehl F, Weber MS, Yuen S, Ziemssen T, Bose G, Freedman MS, Anania VG, Ramesh A, Winger RC, Jia X, Herman A, Harp C, Bar-Or A. Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis. JAMA Neurol. 2024 Mar 11. PMID: 38466277.
      Citations:    
    8. Col NF, Solomon AJ, Alvarez E, Pbert L, Ionete C, BerriosMorales I, Chester J, Kutz C, Iwuchukwu C, Livingston T, Springmann V, Col HV, Ngo LH. Implementing Shared Decision-Making for Multiple Sclerosis: The MS-SUPPORT Tool. Mult Scler Relat Disord. 2023 Dec; 80:105092. PMID: 37931489.
      Citations:    Fields:    Translation:Humans
    9. Chitnis T, Foley J, Ionete C, El Ayoubi NK, Saxena S, Gaitan-Walsh P, Lokhande H, Paul A, Saleh F, Weiner H, Qureshi F, Becich MJ, da Costa FR, Gehman VM, Zhang F, Keshavan A, Jalaleddini K, Ghoreyshi A, Khoury SJ. Clinical validation of a multi-protein, serum-based assay for disease activity assessments in multiple sclerosis. Clin Immunol. 2023 08; 253:109688. PMID: 37414379.
      Citations: 1     Fields:    Translation:Humans
    10. Wilken J, Traboulsee A, Nelson F, Ionete C, Kolind S, Fratto T, Kane R, Gandhi R, Rawlings AM, Roesch N, Ozog MA, DeLuca J. Longitudinal assessment of neurocognitive function in people with relapsing multiple sclerosis initiating alemtuzumab in routine clinical practice: LEM-COG study results. Mult Scler Relat Disord. 2023 May; 73:104677. PMID: 37028124.
      Citations: 2     Fields:    Translation:Humans
    11. Barletta VT, Herranz E, Treaba CA, Mehndiratta A, Ouellette R, Granberg T, Klawiter EC, Ionete C, Sloane JA, Mainero C. In vivo characterization of microglia and myelin relation in multiple sclerosis by combined 11C-PBR28 PET and synthetic MRI. J Neurol. 2023 Jun; 270(6):3091-3102. PMID: 36859627.
      Citations:    Fields:    Translation:HumansCells
    12. Shinoda K, Li R, Rezk A, Mexhitaj I, Patterson KR, Kakara M, Zuroff L, Bennett JL, von B?dingen HC, Carruthers R, Edwards KR, Fallis R, Giacomini PS, Greenberg BM, Hafler DA, Ionete C, Kaunzner UW, Lock CB, Longbrake EE, Pardo G, Piehl F, Weber MS, Ziemssen T, Jacobs D, Gelfand JM, Cross AH, Cameron B, Musch B, Winger RC, Jia X, Harp CT, Herman A, Bar-Or A. Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity. Proc Natl Acad Sci U S A. 2023 01 17; 120(3):e2207291120. PMID: 36634138.
      Citations: 5     Fields:    Translation:HumansCells
    13. Ashkarran AA, Gharibi H, Zeki DA, Radu I, Khalighinejad F, Keyhanian K, Abrahamsson CK, Ionete C, Saei AA, Mahmoudi M. Multi-omics analysis of magnetically levitated plasma biomolecules. Biosens Bioelectron. 2023 Jan 15; 220:114862. PMID: 36403493.
      Citations:    Fields:    Translation:Humans
    14. Hemond CC, Baek J, Ionete C, Reich DS. Paramagnetic rim lesions are associated with pathogenic CSF profiles and worse clinical status in multiple sclerosis: A retrospective cross-sectional study. Mult Scler. 2022 Nov; 28(13):2046-2056. PMID: 35748669.
      Citations: 4     Fields:    Translation:Humans
    15. Currens L, Sivakumar S, Jun-O'Connell AH, Ionete C, Ghasemi M. Neurosyphilis presenting with focal middle cerebral artery stenosis and acute ischemic stroke: A case report. Radiol Case Rep. 2022 May; 17(5):1620-1625. PMID: 35321268.
      Citations:    
    16. Pimentel Maldonado DA, Eusebio JR, Amezcua L, Vasileiou ES, Mowry EM, Hemond CC, Umeton Pizzolato R, Berrios Morales I, Radu I, Ionete C, Fitzgerald KC. The impact of socioeconomic status on mental health and health-seeking behavior across race and ethnicity in a large multiple sclerosis cohort. Mult Scler Relat Disord. 2022 Feb; 58:103451. PMID: 34953410.
      Citations: 5     Fields:    Translation:Humans
    17. Sato S, Buonaccorsi J, Miehm JD, Lim J, Rajala C, Khalighinejad F, Ionete C, Kent JA, van Emmerik REA. Non-ambulatory measures of lower extremity sensorimotor function are associated with walking function in Multiple Sclerosis. Mult Scler Relat Disord. 2021 Aug; 53:103051. PMID: 34139463.
      Citations:    Fields:    Translation:Humans
    18. Bass AD, Arroyo R, Boster AL, Boyko AN, Eichau S, Ionete C, Limmroth V, Navas C, Pelletier D, Pozzilli C, Ravenscroft J, Sousa L, Tintor? M, Uitdehaag BMJ, Baker DP, Daizadeh N, Choudhry Z, Rog D. Alemtuzumab outcomes by age: Post hoc analysis from the randomized CARE-MS studies over 8 years. Mult Scler Relat Disord. 2021 Apr; 49:102717. PMID: 33476880.
      Citations: 3     Fields:    Translation:Humans
    19. Herman JA, Khalighinejad F, York K, Radu I, Berrios Morales I, Ionete C, Hemond CC. A real-world cohort analysis of alemtuzumab outcomes in relapsing multiple sclerosis. Mult Scler Relat Disord. 2021 Jan; 47:102619. PMID: 33189019.
      Citations: 5     Fields:    Translation:Humans
    20. Miehm JD, Buonaccorsi J, Lim J, Sato S, Rajala C, Averill J, Khalighinejad F, Ionete C, Jones SL, Kent JA, van Emmerik RE. Sensorimotor function in progressive multiple sclerosis. Mult Scler J Exp Transl Clin. 2020 Jul-Sep; 6(3):2055217320934835. PMID: 32944271.
      Citations:    
    21. Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Succination inactivates gasdermin D and blocks pyroptosis. Science. 2020 09 25; 369(6511):1633-1637. PMID: 32820063.
      Citations: 198     Fields:    Translation:HumansAnimalsCells
    22. Steingo B, Al Malik Y, Bass AD, Berkovich R, Carraro M, Fern?ndez ?, Ionete C, Massacesi L, Meuth SG, Mitsikostas DD, Pardo G, Simm RF, Traboulsee A, Choudhry Z, Daizadeh N, Compston DAS. Long-term efficacy and safety of alemtuzumab in patients with RRMS: 12-year follow-up of CAMMS223. J Neurol. 2020 Nov; 267(11):3343-3353. PMID: 32583052.
      Citations: 18     Fields:    Translation:Humans
    23. Maghzi AH, Houtchens MK, Preziosa P, Ionete C, Beretich BD, Stankiewicz JM, Tauhid S, Cabot A, Berriosmorales I, Schwartz THW, Sloane JA, Freedman MS, Filippi M, Weiner HL, Bakshi R. COVID-19 in teriflunomide-treated patients with multiple sclerosis. J Neurol. 2020 Oct; 267(10):2790-2796. PMID: 32494856.
      Citations: 33     Fields:    Translation:HumansCellsPHPublic Health
    24. Sato S, Lim J, Miehm JD, Buonaccorsi J, Rajala C, Khalighinejad F, Ionete C, Kent JA, van Emmerik REA. Rapid foot-tapping but not hand-tapping ability is different between relapsing-remitting and progressive multiple sclerosis. Mult Scler Relat Disord. 2020 Jun; 41:102031. PMID: 32172213.
      Citations: 2     Fields:    Translation:Humans
    25. D'Ambrosio E, Khalighinejad F, Ionete C. Intravenous immunoglobulins in an adult case of post-EBV cerebellitis. BMJ Case Rep. 2020 Feb 18; 13(2). PMID: 32075812.
      Citations: 9     Fields:    Translation:Humans
    26. Mahlanza TD, Manieri MC, Klawiter EC, Solomon AJ, Lathi E, Ionete C, Berriosmorales I, Severson C, Stankiewicz J, Cabot A, Elkort M, Chitnis T, Bove R, Katz J, Houtchens M. Prospective growth and developmental outcomes in infants born to mothers with multiple sclerosis. Mult Scler. 2021 01; 27(1):79-89. PMID: 32065561.
      Citations: 4     Fields:    Translation:Humans
    27. Palmer CF, Khalighinejad F, Jun-O'Conell A, Ionete C. A case of isolated cortical venous thrombosis presenting radiographically as a subacute multifocal leukoencephalopathy, and review of literature. BMJ Case Rep. 2019 Oct 25; 12(10). PMID: 31653625.
      Citations: 1     Fields:    Translation:Humans
    28. Col N, Alvarez E, Springmann V, Ionete C, Berrios Morales I, Solomon A, Kutz C, Griffin C, Tierman B, Livingston T, Patel M, van Leeuwen D, Ngo L, Pbert L. A Novel Tool to Improve Shared Decision Making and Adherence in Multiple Sclerosis: Development and Preliminary Testing. MDM Policy Pract. 2019 Jul-Dec; 4(2):2381468319879134. PMID: 31667351.
      Citations:    
    29. Barletta VT, Herranz E, Treaba CA, Ouellette R, Mehndiratta A, Loggia ML, Klawiter EC, Ionete C, Jacob SA, Mainero C. Evidence of diffuse cerebellar neuroinflammation in multiple sclerosis by 11C-PBR28 MR-PET. Mult Scler. 2020 05; 26(6):668-678. PMID: 30973800.
      Citations: 11     Fields:    Translation:HumansCells
    30. Jun-O'connell AH, Henninger N, Moonis M, Silver B, Ionete C, Goddeau RP. Recrudescence of Old Stroke Deficits Among Transient Neurological Attacks. Neurohospitalist. 2019 Oct; 9(4):183-189. PMID: 31534606.
      Citations:    
    31. Col NF, Solomon AJ, Springmann V, Ionete C, Alvarez E, Tierman B, Kutz C, Morales IB, Griffin C, Ngo LH, Jones DE, Phillips G, Hopson A, Pbert L. Evaluation of a Novel Preference Assessment Tool for Patients with Multiple Sclerosis. Int J MS Care. 2018 Nov-Dec; 20(6):260-267. PMID: 30568563.
      Citations:    
    32. Ararat K, Berrios I, Hannoun A, Ionete C. Case of primary Sjogren's syndrome preceded by dystonia. BMJ Case Rep. 2018 Jun 04; 2018. PMID: 29866668.
      Citations: 1     Fields:    Translation:Humans
    33. Col NF, Solomon AJ, Springmann V, Garbin CP, Ionete C, Pbert L, Alvarez E, Tierman B, Hopson A, Kutz C, Berrios Morales I, Griffin C, Phillips G, Ngo LH. Whose Preferences Matter? A Patient-Centered Approach for Eliciting Treatment Goals. Med Decis Making. 2018 01; 38(1):44-55. PMID: 28806143.
      Citations: 20     Fields:    Translation:Humans
    34. Camara-Lemarroy CR, Ibarra-Yruegas BE, Rodriguez-Gutierrez R, Berrios-Morales I, Ionete C, Riskind P. The varieties of psychosis in multiple sclerosis: A systematic review of cases. Mult Scler Relat Disord. 2017 Feb; 12:9-14. PMID: 28283114.
      Citations: 12     Fields:    Translation:Humans
    35. Lee PJ, Berrios I, Ionete C, Smith T. Lymphomatosis cerebri: diagnostic challenges and review of the literature. BMJ Case Rep. 2016 Nov 24; 2016. PMID: 27884882.
      Citations: 3     Fields:    Translation:Humans
    36. Herranz E, Giann? C, Louapre C, Treaba CA, Govindarajan ST, Ouellette R, Loggia ML, Sloane JA, Madigan N, Izquierdo-Garcia D, Ward N, Mangeat G, Granberg T, Klawiter EC, Catana C, Hooker JM, Taylor N, Ionete C, Kinkel RP, Mainero C. Neuroinflammatory component of gray matter pathology in multiple sclerosis. Ann Neurol. 2016 Nov; 80(5):776-790. PMID: 27686563.
      Citations: 77     Fields:    Translation:Humans
    37. Kaushik DK, Yong HY, Hahn JN, Silva C, Casha S, Hurlbert RJ, Jacques FH, Lisak R, Khan O, Ionete C, Larochelle C, Prat A, Bar-Or A, Yong VW. Evaluating Soluble EMMPRIN as a Marker of Disease Activity in Multiple Sclerosis: Studies of Serum and Cerebrospinal Fluid. PLoS One. 2016; 11(10):e0163802. PMID: 27727297.
      Citations: 3     Fields:    Translation:HumansCells
    38. Jun-O'Connell AH, Butala A, Morales IB, Henninger N, Deligiannidis KM, Byatt N, Ionete C. The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis. J Neuropsychiatry Clin Neurosci. 2017; 29(1):45-51. PMID: 27539374.
      Citations: 7     Fields:    Translation:Humans
    39. Rounds WH, Salinas EA, Wilks TB, Levin MK, Ligocki AJ, Ionete C, Pardo CA, Vernino S, Greenberg BM, Bigwood DW, Eastman EM, Cowell LG, Monson NL. MSPrecise: A molecular diagnostic test for multiple sclerosis using next generation sequencing. Gene. 2015 Nov 10; 572(2):191-7. PMID: 26172868.
      Citations: 13     Fields:    Translation:Humans
    40. Berrios I, Jun-O'Connell A, Ghiran S, Ionete C. A case of neurosarcoidosis secondary to treatment of etanercept and review of the literature. BMJ Case Rep. 2015 Jul 06; 2015. PMID: 26150616.
      Citations: 9     Fields:    Translation:Humans
    41. Maze I, Wenderski W, Noh KM, Bagot RC, Tzavaras N, Purushothaman I, Els?sser SJ, Guo Y, Ionete C, Hurd YL, Tamminga CA, Halene T, Farrelly L, Soshnev AA, Wen D, Rafii S, Birtwistle MR, Akbarian S, Buchholz BA, Blitzer RD, Nestler EJ, Yuan ZF, Garcia BA, Shen L, Molina H, Allis CD. Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron. 2015 Jul 01; 87(1):77-94. PMID: 26139371.
      Citations: 146     Fields:    Translation:HumansAnimalsCells
    42. Gnanapavan S, Hegen H, Khalil M, Hemmer B, Franciotta D, Hughes S, Hintzen R, Jeromin A, Havrdova E, Tumani H, Bertolotto A, Comabella M, Frederiksen J, ?lvarez-Cerme?o JC, Villar L, Galimberti D, Myhr KM, Dujmovic I, Fazekas F, Ionete C, Menge T, Kuhle J, Keir G, Deisenhammer F, Teunissen C, Giovannoni G. Guidelines for uniform reporting of body fluid biomarker studies in neurologic disorders. Neurology. 2014 Sep 23; 83(13):1210-6. PMID: 25150289.
      Citations: 14     Fields:    Translation:Humans
    43. Chalkias S, Dang X, Bord E, Stein MC, Kinkel RP, Sloane JA, Donnelly M, Ionete C, Houtchens MK, Buckle GJ, Batson S, Koralnik IJ. JC virus reactivation during prolonged natalizumab monotherapy for multiple sclerosis. Ann Neurol. 2014 Jun; 75(6):925-34. PMID: 24687904.
      Citations: 27     Fields:    Translation:HumansCells
    44. Cachia D, Izzy S, Berriosmorales I, Ionete C. Drug-induced thrombocytopenia secondary to natalizumab treatment. BMJ Case Rep. 2014 May 30; 2014. PMID: 24879724.
      Citations: 3     Fields:    Translation:Humans
    45. Tanasescu R, Ionete C, Chou IJ, Constantinescu CS. Advances in the treatment of relapsing-remitting multiple sclerosis. Biomed J. 2014 Mar-Apr; 37(2):41-9. PMID: 24732658.
      Citations: 16     Fields:    Translation:HumansAnimals
    46. Paradas C, Akman HO, Ionete C, Lau H, Riskind PN, Jones DE, Smith TW, Hirano M, Dimauro S. Branching enzyme deficiency: expanding the clinical spectrum. JAMA Neurol. 2014 Jan; 71(1):41-7. PMID: 24248152.
      Citations: 16     Fields:    Translation:Humans
    47. Cachia D, Izzy S, Smith T, Ionete C. A rare presentation of hypertrophic olivary degeneration secondary to primary central nervous system lymphoma. JAMA Neurol. 2013 Sep 01; 70(9):1192-3. PMID: 23857254.
      Citations: 2     Fields:    Translation:Humans
    48. Cachia D, Izzy S, Ionete C, Salameh J. Brachial amyotrophic diplegia in the setting of complete HIV viral load suppression. BMJ Case Rep. 2012 Dec 06; 2012. PMID: 23220836.
      Citations: 2     Fields:    Translation:Humans
    49. Byatt N, Rothschild AJ, Riskind P, Ionete C, Hunt AT. Relationships between multiple sclerosis and depression. J Neuropsychiatry Clin Neurosci. 2011; 23(2):198-200. PMID: 21677250.
      Citations: 15     Fields:    Translation:Humans
    50. Ionete C, Omojola MF. MR angiographic demonstration of bilateral duplication of the extracranial vertebral artery: unusual course and review of the literature. AJNR Am J Neuroradiol. 2006 Jun-Jul; 27(6):1304-6. PMID: 16775285.
      Citations: 25     Fields:    Translation:Humans
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