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Carolina Ionete MD, PhD

InstitutionUMass Chan Medical School
AddressUMass Memorial Medical Center
119 Belmont Street
Worcester MA 01605
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    InstitutionT.H. Chan School of Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    Collapse Biography 
    Collapse education and training
    Carol Davila University of Medicine and Pharmacy, Bucharest, , RomaniaMD
    Carol Davila University of Medicine and Pharmacy, Bucharest, , RomaniaPHDMedicine

    Collapse Overview 
    Collapse Summary
    Dr. Ionete is a clinical neuroimmunologist and educator with special interests including clinical trials in multiple sclerosis and other autoimmune neurological diseases, and neurological complications of HIV infections. She chairs the Department of Neurology's education committee.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hemond CC, Baek J, Ionete C, Reich DS. Paramagnetic rim lesions are associated with pathogenic CSF profiles and worse clinical status in multiple sclerosis: A retrospective cross-sectional study. Mult Scler. 2022 Nov; 28(13):2046-2056. PMID: 35748669.
      Citations:    Fields:    
    2. Currens L, Sivakumar S, Jun-O'Connell AH, Ionete C, Ghasemi M. Neurosyphilis presenting with focal middle cerebral artery stenosis and acute ischemic stroke: A case report. Radiol Case Rep. 2022 May; 17(5):1620-1625. PMID: 35321268.
    3. Pimentel Maldonado DA, Eusebio JR, Amezcua L, Vasileiou ES, Mowry EM, Hemond CC, Umeton Pizzolato R, Berrios Morales I, Radu I, Ionete C, Fitzgerald KC. The impact of socioeconomic status on mental health and health-seeking behavior across race and ethnicity in a large multiple sclerosis cohort. Mult Scler Relat Disord. 2022 Feb; 58:103451. PMID: 34953410.
      Citations: 1     Fields:    Translation:Humans
    4. Sato S, Buonaccorsi J, Miehm JD, Lim J, Rajala C, Khalighinejad F, Ionete C, Kent JA, van Emmerik REA. Non-ambulatory measures of lower extremity sensorimotor function are associated with walking function in Multiple Sclerosis. Mult Scler Relat Disord. 2021 Aug; 53:103051. PMID: 34139463.
      Citations:    Fields:    Translation:Humans
    5. Bass AD, Arroyo R, Boster AL, Boyko AN, Eichau S, Ionete C, Limmroth V, Navas C, Pelletier D, Pozzilli C, Ravenscroft J, Sousa L, Tintoré M, Uitdehaag BMJ, Baker DP, Daizadeh N, Choudhry Z, Rog D. Alemtuzumab outcomes by age: Post hoc analysis from the randomized CARE-MS studies over 8 years. Mult Scler Relat Disord. 2021 Apr; 49:102717. PMID: 33476880.
      Citations: 2     Fields:    Translation:Humans
    6. Herman JA, Khalighinejad F, York K, Radu I, Berrios Morales I, Ionete C, Hemond CC. A real-world cohort analysis of alemtuzumab outcomes in relapsing multiple sclerosis. Mult Scler Relat Disord. 2021 Jan; 47:102619. PMID: 33189019.
      Citations: 2     Fields:    Translation:Humans
    7. Miehm JD, Buonaccorsi J, Lim J, Sato S, Rajala C, Averill J, Khalighinejad F, Ionete C, Jones SL, Kent JA, van Emmerik RE. Sensorimotor function in progressive multiple sclerosis. Mult Scler J Exp Transl Clin. 2020 Jul-Sep; 6(3):2055217320934835. PMID: 32944271.
    8. Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Succination inactivates gasdermin D and blocks pyroptosis. Science. 2020 09 25; 369(6511):1633-1637. PMID: 32820063.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    9. Steingo B, Al Malik Y, Bass AD, Berkovich R, Carraro M, Fernández Ó, Ionete C, Massacesi L, Meuth SG, Mitsikostas DD, Pardo G, Simm RF, Traboulsee A, Choudhry Z, Daizadeh N, Compston DAS. Long-term efficacy and safety of alemtuzumab in patients with RRMS: 12-year follow-up of CAMMS223. J Neurol. 2020 Nov; 267(11):3343-3353. PMID: 32583052.
      Citations: 8     Fields:    Translation:Humans
    10. Maghzi AH, Houtchens MK, Preziosa P, Ionete C, Beretich BD, Stankiewicz JM, Tauhid S, Cabot A, Berriosmorales I, Schwartz THW, Sloane JA, Freedman MS, Filippi M, Weiner HL, Bakshi R. COVID-19 in teriflunomide-treated patients with multiple sclerosis. J Neurol. 2020 Oct; 267(10):2790-2796. PMID: 32494856.
      Citations: 27     Fields:    Translation:HumansCellsPHPublic Health
    11. Sato S, Lim J, Miehm JD, Buonaccorsi J, Rajala C, Khalighinejad F, Ionete C, Kent JA, van Emmerik REA. Rapid foot-tapping but not hand-tapping ability is different between relapsing-remitting and progressive multiple sclerosis. Mult Scler Relat Disord. 2020 Jun; 41:102031. PMID: 32172213.
      Citations: 1     Fields:    Translation:Humans
    12. D'Ambrosio E, Khalighinejad F, Ionete C. Intravenous immunoglobulins in an adult case of post-EBV cerebellitis. BMJ Case Rep. 2020 Feb 18; 13(2). PMID: 32075812.
      Citations: 3     Fields:    Translation:Humans
    13. Mahlanza TD, Manieri MC, Klawiter EC, Solomon AJ, Lathi E, Ionete C, Berriosmorales I, Severson C, Stankiewicz J, Cabot A, Elkort M, Chitnis T, Bove R, Katz J, Houtchens M. Prospective growth and developmental outcomes in infants born to mothers with multiple sclerosis. Mult Scler. 2021 01; 27(1):79-89. PMID: 32065561.
      Citations: 2     Fields:    Translation:Humans
    14. Palmer CF, Khalighinejad F, Jun-O'Conell A, Ionete C. A case of isolated cortical venous thrombosis presenting radiographically as a subacute multifocal leukoencephalopathy, and review of literature. BMJ Case Rep. 2019 Oct 25; 12(10). PMID: 31653625.
      Citations: 1     Fields:    Translation:Humans
    15. Col N, Alvarez E, Springmann V, Ionete C, Berrios Morales I, Solomon A, Kutz C, Griffin C, Tierman B, Livingston T, Patel M, van Leeuwen D, Ngo L, Pbert L. A Novel Tool to Improve Shared Decision Making and Adherence in Multiple Sclerosis: Development and Preliminary Testing. MDM Policy Pract. 2019 Jul-Dec; 4(2):2381468319879134. PMID: 31667351.
    16. Barletta VT, Herranz E, Treaba CA, Ouellette R, Mehndiratta A, Loggia ML, Klawiter EC, Ionete C, Jacob SA, Mainero C. Evidence of diffuse cerebellar neuroinflammation in multiple sclerosis by 11C-PBR28 MR-PET. Mult Scler. 2020 05; 26(6):668-678. PMID: 30973800.
      Citations: 6     Fields:    Translation:HumansCells
    17. Jun-O'connell AH, Henninger N, Moonis M, Silver B, Ionete C, Goddeau RP. Recrudescence of Old Stroke Deficits Among Transient Neurological Attacks. Neurohospitalist. 2019 Oct; 9(4):183-189. PMID: 31534606.
    18. Col NF, Solomon AJ, Springmann V, Ionete C, Alvarez E, Tierman B, Kutz C, Morales IB, Griffin C, Ngo LH, Jones DE, Phillips G, Hopson A, Pbert L. Evaluation of a Novel Preference Assessment Tool for Patients with Multiple Sclerosis. Int J MS Care. 2018 Nov-Dec; 20(6):260-267. PMID: 30568563.
    19. Ararat K, Berrios I, Hannoun A, Ionete C. Case of primary Sjogren's syndrome preceded by dystonia. BMJ Case Rep. 2018 Jun 04; 2018. PMID: 29866668.
      Citations: 1     Fields:    Translation:Humans
    20. Col NF, Solomon AJ, Springmann V, Garbin CP, Ionete C, Pbert L, Alvarez E, Tierman B, Hopson A, Kutz C, Berrios Morales I, Griffin C, Phillips G, Ngo LH. Whose Preferences Matter? A Patient-Centered Approach for Eliciting Treatment Goals. Med Decis Making. 2018 01; 38(1):44-55. PMID: 28806143.
      Citations: 16     Fields:    Translation:Humans
    21. Camara-Lemarroy CR, Ibarra-Yruegas BE, Rodriguez-Gutierrez R, Berrios-Morales I, Ionete C, Riskind P. The varieties of psychosis in multiple sclerosis: A systematic review of cases. Mult Scler Relat Disord. 2017 Feb; 12:9-14. PMID: 28283114.
      Citations: 8     Fields:    Translation:Humans
    22. Lee PJ, Berrios I, Ionete C, Smith T. Lymphomatosis cerebri: diagnostic challenges and review of the literature. BMJ Case Rep. 2016 Nov 24; 2016. PMID: 27884882.
      Citations: 2     Fields:    Translation:Humans
    23. Herranz E, Giannì C, Louapre C, Treaba CA, Govindarajan ST, Ouellette R, Loggia ML, Sloane JA, Madigan N, Izquierdo-Garcia D, Ward N, Mangeat G, Granberg T, Klawiter EC, Catana C, Hooker JM, Taylor N, Ionete C, Kinkel RP, Mainero C. Neuroinflammatory component of gray matter pathology in multiple sclerosis. Ann Neurol. 2016 Nov; 80(5):776-790. PMID: 27686563.
      Citations: 62     Fields:    Translation:Humans
    24. Kaushik DK, Yong HY, Hahn JN, Silva C, Casha S, Hurlbert RJ, Jacques FH, Lisak R, Khan O, Ionete C, Larochelle C, Prat A, Bar-Or A, Yong VW. Evaluating Soluble EMMPRIN as a Marker of Disease Activity in Multiple Sclerosis: Studies of Serum and Cerebrospinal Fluid. PLoS One. 2016; 11(10):e0163802. PMID: 27727297.
      Citations: 3     Fields:    Translation:HumansCells
    25. Jun-O'Connell AH, Butala A, Morales IB, Henninger N, Deligiannidis KM, Byatt N, Ionete C. The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis. J Neuropsychiatry Clin Neurosci. 2017; 29(1):45-51. PMID: 27539374.
      Citations: 6     Fields:    Translation:Humans
    26. Rounds WH, Salinas EA, Wilks TB, Levin MK, Ligocki AJ, Ionete C, Pardo CA, Vernino S, Greenberg BM, Bigwood DW, Eastman EM, Cowell LG, Monson NL. MSPrecise: A molecular diagnostic test for multiple sclerosis using next generation sequencing. Gene. 2015 Nov 10; 572(2):191-7. PMID: 26172868.
      Citations: 13     Fields:    Translation:Humans
    27. Berrios I, Jun-O'Connell A, Ghiran S, Ionete C. A case of neurosarcoidosis secondary to treatment of etanercept and review of the literature. BMJ Case Rep. 2015 Jul 06; 2015. PMID: 26150616.
      Citations: 9     Fields:    Translation:Humans
    28. Maze I, Wenderski W, Noh KM, Bagot RC, Tzavaras N, Purushothaman I, Elsässer SJ, Guo Y, Ionete C, Hurd YL, Tamminga CA, Halene T, Farrelly L, Soshnev AA, Wen D, Rafii S, Birtwistle MR, Akbarian S, Buchholz BA, Blitzer RD, Nestler EJ, Yuan ZF, Garcia BA, Shen L, Molina H, Allis CD. Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron. 2015 Jul 01; 87(1):77-94. PMID: 26139371.
      Citations: 113     Fields:    Translation:HumansAnimalsCells
    29. Gnanapavan S, Hegen H, Khalil M, Hemmer B, Franciotta D, Hughes S, Hintzen R, Jeromin A, Havrdova E, Tumani H, Bertolotto A, Comabella M, Frederiksen J, Álvarez-Cermeño JC, Villar L, Galimberti D, Myhr KM, Dujmovic I, Fazekas F, Ionete C, Menge T, Kuhle J, Keir G, Deisenhammer F, Teunissen C, Giovannoni G. Guidelines for uniform reporting of body fluid biomarker studies in neurologic disorders. Neurology. 2014 Sep 23; 83(13):1210-6. PMID: 25150289.
      Citations: 14     Fields:    Translation:Humans
    30. Chalkias S, Dang X, Bord E, Stein MC, Kinkel RP, Sloane JA, Donnelly M, Ionete C, Houtchens MK, Buckle GJ, Batson S, Koralnik IJ. JC virus reactivation during prolonged natalizumab monotherapy for multiple sclerosis. Ann Neurol. 2014 Jun; 75(6):925-34. PMID: 24687904.
      Citations: 26     Fields:    Translation:HumansCells
    31. Cachia D, Izzy S, Berriosmorales I, Ionete C. Drug-induced thrombocytopenia secondary to natalizumab treatment. BMJ Case Rep. 2014 May 30; 2014. PMID: 24879724.
      Citations: 2     Fields:    Translation:Humans
    32. Tanasescu R, Ionete C, Chou IJ, Constantinescu CS. Advances in the treatment of relapsing-remitting multiple sclerosis. Biomed J. 2014 Mar-Apr; 37(2):41-9. PMID: 24732658.
      Citations: 13     Fields:    Translation:HumansAnimals
    33. Paradas C, Akman HO, Ionete C, Lau H, Riskind PN, Jones DE, Smith TW, Hirano M, Dimauro S. Branching enzyme deficiency: expanding the clinical spectrum. JAMA Neurol. 2014 Jan; 71(1):41-7. PMID: 24248152.
      Citations: 12     Fields:    Translation:Humans
    34. Cachia D, Izzy S, Smith T, Ionete C. A rare presentation of hypertrophic olivary degeneration secondary to primary central nervous system lymphoma. JAMA Neurol. 2013 Sep 01; 70(9):1192-3. PMID: 23857254.
      Citations: 2     Fields:    Translation:Humans
    35. Cachia D, Izzy S, Ionete C, Salameh J. Brachial amyotrophic diplegia in the setting of complete HIV viral load suppression. BMJ Case Rep. 2012 Dec 06; 2012. PMID: 23220836.
      Citations: 2     Fields:    Translation:Humans
    36. Byatt N, Rothschild AJ, Riskind P, Ionete C, Hunt AT. Relationships between multiple sclerosis and depression. J Neuropsychiatry Clin Neurosci. 2011; 23(2):198-200. PMID: 21677250.
      Citations: 15     Fields:    Translation:Humans
    37. Ionete C, Omojola MF. MR angiographic demonstration of bilateral duplication of the extracranial vertebral artery: unusual course and review of the literature. AJNR Am J Neuroradiol. 2006 Jun-Jul; 27(6):1304-6. PMID: 16775285.
      Citations: 25     Fields:    Translation:Humans
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