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David V Serreze PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
AddressJackson Laboratory
600 Main Street
Bar Harbor ME 04609
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    Other Positions
    InstitutionT.H. Chan School of Medicine

    Collapse Biography 
    Collapse education and training
    University of Maine, Orono, Orono, ME, United StatesBSBiology
    University of Maine, Orono, Orono, ME, United StatesMSMicrobiology
    University of Maine, Orono, Orono, ME, United StatesPHDMicrobiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Racine JJ, Bachman JF, Zhang JG, Misherghi A, Khadour R, Kaisar S, Bedard O, Jenkins C, Abbott A, Forte E, Rainer P, Rosenthal N, Sattler S, Serreze DV. Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy. J Immunol. 2024 Apr 15; 212(8):1287-1306. PMID: 38426910.
    2. Racine JJ, Misherghi A, Dwyer JR, Maser R, Forte E, Bedard O, Sattler S, Pugliese A, Landry L, Elso C, Nakayama M, Mannering S, Rosenthal N, Serreze DV. HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice. J Immunol. 2023 Dec 15; 211(12):1792-1805. PMID: 37877672.
      Citations:    Fields:    
    3. Ye C, Clements SA, Gu W, Geurts AM, Mathews CE, Serreze DV, Chen YG, Driver JP. Deletion of V?3+CD4+ T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8+ T cells. Proc Natl Acad Sci U S A. 2023 Dec 05; 120(49):e2312039120. PMID: 38015847.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Ciecko AE, Wang Y, Harleston S, Drewek A, Serreze DV, Geurts AM, Lin CW, Chen YG. Heterogeneity of Islet-Infiltrating IL-21+ CD4 T Cells in a Mouse Model of Type 1 Diabetes. J Immunol. 2023 04 01; 210(7):935-946. PMID: 36762954.
      Citations: 2     Fields:    Translation:AnimalsCells
    5. Funsten MC, Yurkovetskiy LA, Kuznetsov A, Reiman D, Hansen CHF, Senter KI, Lee J, Ratiu J, Dahal-Koirala S, Antonopoulos DA, Dunny GM, Sollid LM, Serreze D, Khan AA, Chervonsky AV. Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes. Cell Host Microbe. 2023 02 08; 31(2):213-227.e9. PMID: 36603588.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    6. Racine JJ, Morel L, Chen YG, Serreze DV. Editorial: Genetic basis of tolerance induction defects underlying the development of autoimmune pathologies. Front Immunol. 2022; 13:1069232. PMID: 36389740.
      Citations:    Fields:    Translation:Humans
    7. Dwyer JR, Racine JJ, Chapman HD, Quinlan A, Presa M, Stafford GA, Schmitz I, Serreze DV. Nfkbid Overexpression in Nonobese Diabetic Mice Elicits Complete Type 1 Diabetes Resistance in Part Associated with Enhanced Thymic Deletion of Pathogenic CD8 T Cells and Increased Numbers and Activity of Regulatory T Cells. J Immunol. 2022 07 15; 209(2):227-237. PMID: 35760520.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    8. Break TJ, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison OJ, Alejo J, Williams DW, Pittaluga S, Lee CR, Bouladoux N, Swamydas M, Hoffman KW, Greenwell-Wild T, Bruno VM, Rosen LB, Lwin W, Renteria A, Pontejo SM, Shannon JP, Myles IA, Olbrich P, Ferr? EMN, Schmitt M, Martin D, Barber DL, Solis NV, Notarangelo LD, Serreze DV, Matsumoto M, Hickman HD, Murphy PM, Anderson MS, Lim JK, Holland SM, Filler SG, Afzali B, Belkaid Y, Moutsopoulos NM, Lionakis MS. Response to Comments on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections". Science. 2021 Sep 17; 373(6561):eabi8835. PMID: 34529475.
      Citations: 4     Fields:    Translation:HumansAnimals
    9. Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG. Interleukin-27 is essential for type 1 diabetes development and Sj?gren syndrome-like inflammation. Cell Rep. 2021 Feb 02; 34(5):108725. PMID: 33535031.
      Citations: 1     Fields:    
    10. Break TJ, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison OJ, Alejo J, Williams DW, Pittaluga S, Lee CR, Bouladoux N, Swamydas M, Hoffman KW, Greenwell-Wild T, Bruno VM, Rosen LB, Lwin W, Renteria A, Pontejo SM, Shannon JP, Myles IA, Olbrich P, Ferr? EMN, Schmitt M, Martin D, Barber DL, Solis NV, Notarangelo LD, Serreze DV, Matsumoto M, Hickman HD, Murphy PM, Anderson MS, Lim JK, Holland SM, Filler SG, Afzali B, Belkaid Y, Moutsopoulos NM, Lionakis MS. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021 01 15; 371(6526). PMID: 33446526.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    11. Debreceni IL, Chimenti MS, Serreze DV, Geurts AM, Chen YG, Lieberman SM. Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice. Int J Mol Sci. 2020 Dec 13; 21(24). PMID: 33322152.
      Citations: 6     Fields:    Translation:AnimalsCells
    12. Racine JJ, Chapman HD, Doty R, Cairns BM, Hines TJ, Tadenev ALD, Anderson LC, Green T, Dyer ME, Wotton JM, Bichler Z, White JK, Ettinger R, Burgess RW, Serreze DV. T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue. J Immunol. 2020 10 15; 205(8):2026-2038. PMID: 32938729.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM. CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation. Front Immunol. 2020; 11:2180. PMID: 33013915.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    14. Ye C, Low BE, Wiles MV, Brusko TM, Serreze DV, Driver JP. CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice. J Immunol. 2020 10 01; 205(7):1763-1777. PMID: 32868408.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    15. Wright JJ, Saunders DC, Dai C, Poffenberger G, Cairns B, Serreze DV, Harlan DM, Bottino R, Brissova M, Powers AC. Decreased pancreatic acinar cell number in type 1 diabetes. Diabetologia. 2020 07; 63(7):1418-1423. PMID: 32388592.
      Citations: 28     Fields:    Translation:AnimalsCells
    16. Foda BM, Ciecko AE, Serreze DV, Ridgway WM, Geurts AM, Chen YG. The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137+ FOXP3+ Regulatory CD4 T Cells. J Immunol. 2020 06 01; 204(11):2887-2899. PMID: 32295876.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    17. Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG. Interleukin-27 Is Essential for Type 1 Diabetes Development and Sj?gren Syndrome-like Inflammation. Cell Rep. 2019 12 03; 29(10):3073-3086.e5. PMID: 31801074.
      Citations: 19     Fields:    Translation:AnimalsCells
    18. De Groot AS, Skowron G, White JR, Boyle C, Richard G, Serreze D, Martin WD. Therapeutic administration of Tregitope-Human Albumin Fusion with Insulin Peptides to promote Antigen-Specific Adaptive Tolerance Induction. Sci Rep. 2019 11 06; 9(1):16103. PMID: 31695065.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    19. Egia-Mendikute L, Arpa B, Rosell-Mases E, Corral-Pujol M, Carrascal J, Carrillo J, Mora C, Chapman H, Panosa A, Vives-Pi M, Stratmann T, Serreze D, Verdaguer J. B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes. Front Immunol. 2019; 10:1732. PMID: 31428087.
      Citations: 2     Fields:    Translation:AnimalsCells
    20. Forsberg MH, Foda B, Serreze DV, Chen YG. Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus. Sci Rep. 2019 03 13; 9(1):4316. PMID: 30867509.
      Citations: 5     Fields:    Translation:AnimalsCells
    21. Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS. CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. Front Immunol. 2019; 10:99. PMID: 30766536.
      Citations: 18     Fields:    Translation:AnimalsCells
    22. Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Allocco J, Chapman HD, Serreze DV. A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice. J Immunol. 2018 10 01; 201(7):1907-1917. PMID: 30127089.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    23. Schloss J, Ali R, Racine JJ, Chapman HD, Serreze DV, DiLorenzo TP. HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression. J Immunol. 2018 05 15; 200(10):3353-3363. PMID: 29632144.
      Citations: 7     Fields:    Translation:AnimalsCells
    24. Racine JJ, Stewart I, Ratiu J, Christianson G, Lowell E, Helm K, Allocco J, Maser RS, Chen YG, Lutz CM, Roopenian D, Schloss J, DiLorenzo TP, Serreze DV. Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development. Diabetes. 2018 05; 67(5):923-935. PMID: 29472249.
      Citations: 7     Fields:    Translation:HumansAnimals
    25. Wang Q, Racine JJ, Ratiu JJ, Wang S, Ettinger R, Wasserfall C, Atkinson MA, Serreze DV. Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy. J Immunol. 2017 12 01; 199(11):3757-3770. PMID: 29055002.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    26. Fahey JR, Lyons BL, Olekszak HL, Mourino AJ, Ratiu JJ, Racine JJ, Chapman HD, Serreze DV, Baker DL, Hendrix NK. Antibiotic-associated Manipulation of the Gut Microbiota and Phenotypic Restoration in NOD Mice. Comp Med. 2017 Aug 01; 67(4):335-343. PMID: 28830580.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    27. Ratiu JJ, Racine JJ, Hasham MG, Wang Q, Branca JA, Chapman HD, Zhu J, Donghia N, Philip V, Schott WH, Wasserfall C, Atkinson MA, Mills KD, Leeth CM, Serreze DV. Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes. J Immunol. 2017 06 01; 198(11):4255-4267. PMID: 28461573.
      Citations: 20     Fields:    Translation:AnimalsCells
    28. Driver JP, Racine JJ, Ye C, Lamont DJ, Newby BN, Leeth CM, Chapman HD, Brusko TM, Chen YG, Mathews CE, Serreze DV. Interferon-? Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes. Diabetes. 2017 03; 66(3):710-721. PMID: 27920091.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    29. Lin B, Ciecko AE, MacKinney E, Serreze DV, Chen YG. Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice. Immunogenetics. 2017 03; 69(3):193-198. PMID: 27796442.
      Citations: 1     Fields:    Translation:AnimalsCells
    30. Mahmoud TI, Wang J, Karnell JL, Wang Q, Wang S, Naiman B, Gross P, Brohawn PZ, Morehouse C, Aoyama J, Wasserfall C, Carter L, Atkinson MA, Serreze DV, Braley-Mullen H, Mustelin T, Kolbeck R, Herbst R, Ettinger R. Autoimmune manifestations in aged mice arise from early-life immune dysregulation. Sci Transl Med. 2016 10 19; 8(361):361ra137. PMID: 27798262.
      Citations: 21     Fields:    Translation:AnimalsCells
    31. Leeth CM, Racine J, Chapman HD, Arpa B, Carrillo J, Carrascal J, Wang Q, Ratiu J, Egia-Mendikute L, Rosell-Mases E, Stratmann T, Verdaguer J, Serreze DV. B-lymphocytes expressing an Ig specificity recognizing the pancreatic ?-cell autoantigen peripherin are potent contributors to type 1 diabetes development in NOD mice. Diabetes. 2016 07; 65(7):1977-1987. PMID: 26961115.
      Citations: 15     Fields:    
    32. Serreze DV, Niens M, Kulik J, DiLorenzo TP. Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans. Methods Mol Biol. 2016; 1438:137-51. PMID: 27150089.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    33. Scheuplein F, Lamont DJ, Poynter ME, Boyson JE, Serreze D, Lundblad LK, Mashal R, Schaub R. Mouse Invariant Monoclonal Antibody NKT14: A Novel Tool to Manipulate iNKT Cell Function In Vivo. PLoS One. 2015; 10(10):e0140729. PMID: 26474487.
      Citations: 14     Fields:    Translation:AnimalsCells
    34. Presa M, Chen YG, Grier AE, Leiter EH, Brehm MA, Greiner DL, Shultz LD, Serreze DV. The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice. J Immunol. 2015 Oct 01; 195(7):3011-9. PMID: 26283479.
      Citations: 10     Fields:    Translation:AnimalsCells
    35. Kom?romy AM, Abrams KL, Heckenlively JR, Lundy SK, Maggs DJ, Leeth CM, MohanKumar PS, Petersen-Jones SM, Serreze DV, van der Woerdt A. Sudden acquired retinal degeneration syndrome (SARDS) - a review and proposed strategies toward a better understanding of pathogenesis, early diagnosis, and therapy. Vet Ophthalmol. 2016 Jul; 19(4):319-31. PMID: 26096588.
      Citations: 8     Fields:    Translation:Animals
    36. Simecek P, Churchill GA, Yang H, Rowe LB, Herberg L, Serreze DV, Leiter EH. Genetic Analysis of Substrain Divergence in Non-Obese Diabetic (NOD) Mice. G3 (Bethesda). 2015 Mar 03; 5(5):771-5. PMID: 25740934.
      Citations: 16     Fields:    Translation:Animals
    37. Lamont D, Mukherjee G, Kumar PR, Samanta D, McPhee CG, Kay TW, Almo SC, DiLorenzo TP, Serreze DV. Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses. J Immunol. 2014 Sep 01; 193(5):2135-46. PMID: 25063871.
      Citations: 16     Fields:    Translation:AnimalsCells
    38. Garabatos N, Alvarez R, Carrillo J, Carrascal J, Izquierdo C, Chapman HD, Presa M, Mora C, Serreze DV, Verdaguer J, Stratmann T. In vivo detection of peripherin-specific autoreactive B cells during type 1 diabetes pathogenesis. J Immunol. 2014 Apr 01; 192(7):3080-90. PMID: 24610011.
      Citations: 9     Fields:    Translation:AnimalsCells
    39. Mukherjee G, Geliebter A, Babad J, Santamaria P, Serreze DV, Freeman GJ, Tarbell KV, Sharpe A, DiLorenzo TP. DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8? T cells independently of PD-1 and PD-L1. Int Immunol. 2013 Nov; 25(11):651-60. PMID: 24021877.
      Citations: 16     Fields:    Translation:AnimalsCells
    40. Presa M, Ortiz AZ, Garabatos N, Izquierdo C, Rivas EI, Teyton L, Mora C, Serreze D, Stratmann T. Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice. Eur J Immunol. 2013 Nov; 43(11):2969-79. PMID: 23925934.
      Citations: 5     Fields:    Translation:AnimalsCells
    41. Lee JS, Scandiuzzi L, Ray A, Wei J, Hofmeyer KA, Abadi YM, Loke P, Lin J, Yuan J, Serreze DV, Allison JP, Zang X. B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells. J Immunol. 2012 Oct 15; 189(8):4165-74. PMID: 22972920.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    42. Stolp J, Chen YG, Cox SL, Henck V, Zhang W, Tsaih SW, Chapman H, Stearns T, Serreze DV, Silveira PA. Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice. J Immunol. 2012 Aug 01; 189(3):1406-17. PMID: 22732593.
      Citations: 8     Fields:    Translation:AnimalsCells
    43. Bogdanik LP, Chapman HD, Miers KE, Serreze DV, Burgess RW. A MusD retrotransposon insertion in the mouse Slc6a5 gene causes alterations in neuromuscular junction maturation and behavioral phenotypes. PLoS One. 2012; 7(1):e30217. PMID: 22272310.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    44. Wekerle H, Fl?gel A, Fugger L, Schett G, Serreze D. Autoimmunity's next top models. Nat Med. 2012 Jan 06; 18(1):66-70. PMID: 22227675.
      Citations: 21     Fields:    Translation:HumansAnimals
    45. Driver JP, Lamont DJ, Gysemans C, Mathieu C, Serreze DV. Calcium insufficiency accelerates type 1 diabetes in vitamin D receptor-deficient nonobese diabetic (NOD) mice. Endocrinology. 2011 Dec; 152(12):4620-9. PMID: 21952242.
      Citations: 5     Fields:    Translation:AnimalsCells
    46. Serreze DV, Chapman HD, Niens M, Dunn R, Kehry MR, Driver JP, Haller M, Wasserfall C, Atkinson MA. Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies. Diabetes. 2011 Nov; 60(11):2914-21. PMID: 21926271.
      Citations: 44     Fields:    Translation:AnimalsCells
    47. Chen YG, Scheuplein F, Driver JP, Hewes AA, Reifsnyder PC, Leiter EH, Serreze DV. Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice. J Immunol. 2011 Apr 01; 186(7):4278-84. PMID: 21357538.
      Citations: 16     Fields:    Translation:AnimalsCells
    48. Rivas EI, Driver JP, Garabatos N, Presa M, Mora C, Rodriguez F, Serreze DV, Stratmann T. Targeting of a T cell agonist peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse. J Immunol. 2011 Apr 01; 186(7):4078-87. PMID: 21346228.
      Citations: 7     Fields:    Translation:AnimalsCells
    49. Niens M, Grier AE, Marron M, Kay TW, Greiner DL, Serreze DV. Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach. Diabetes. 2011 Apr; 60(4):1229-36. PMID: 21346176.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    50. Driver JP, Chen YG, Zhang W, Asrat S, Serreze DV. Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses. Diabetes. 2011 Apr; 60(4):1354-9. PMID: 21307079.
      Citations: 3     Fields:    Translation:AnimalsCells
    51. Cox SL, Stolp J, Hallahan NL, Counotte J, Zhang W, Serreze DV, Basten A, Silveira PA. Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a ?-cell neo-self-antigen in type 1 diabetes prone NOD mice. Eur J Immunol. 2010 Dec; 40(12):3413-25. PMID: 21108464.
      Citations: 6     Fields:    Translation:AnimalsCells
    52. Driver JP, Serreze DV, Chen YG. Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Semin Immunopathol. 2011 Jan; 33(1):67-87. PMID: 20424843.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    53. Strom A, Sonier B, Chapman HD, Mojibian M, Wang GS, Slatculescu CR, Serreze DV, Scott FW. Peripherin-reactive antibodies in mouse, rabbit, and human blood. J Proteome Res. 2010 Mar 05; 9(3):1203-8. PMID: 20113007.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    54. Serreze DV, Niens M, Kulik J, Dilorenzo TP. Bridging mice to men: using HLA transgenic mice to enhance the future prediction and prevention of autoimmune type 1 diabetes in humans. Methods Mol Biol. 2010; 602:119-34. PMID: 20012396.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    55. Driver JP, Scheuplein F, Chen YG, Grier AE, Wilson SB, Serreze DV. Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette. Diabetes. 2010 Feb; 59(2):423-32. PMID: 19903740.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    56. Scheuplein F, Rissiek B, Driver JP, Chen YG, Koch-Nolte F, Serreze DV. A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes. J Autoimmun. 2010 Mar; 34(2):145-54. PMID: 19796917.
      Citations: 19     Fields:    Translation:AnimalsCells
    57. Wesolowski J, Alzogaray V, Reyelt J, Unger M, Juarez K, Urrutia M, Cauerhff A, Danquah W, Rissiek B, Scheuplein F, Schwarz N, Adriouch S, Boyer O, Seman M, Licea A, Serreze DV, Goldbaum FA, Haag F, Koch-Nolte F. Single domain antibodies: promising experimental and therapeutic tools in infection and immunity. Med Microbiol Immunol. 2009 Aug; 198(3):157-74. PMID: 19529959.
      Citations: 207     Fields:    Translation:AnimalsCells
    58. Mangada J, Pearson T, Brehm MA, Wicker LS, Peterson LB, Shultz LD, Serreze DV, Rossini AA, Greiner DL. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes. 2009 Jan; 58(1):165-73. PMID: 18984741.
      Citations: 5     Fields:    Translation:AnimalsCells
    59. Chen YG, Scheuplein F, Osborne MA, Tsaih SW, Chapman HD, Serreze DV. Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice. Diabetes. 2008 Dec; 57(12):3273-80. PMID: 18776136.
      Citations: 15     Fields:    Translation:AnimalsCells
    60. Mukhopadhaya A, Hanafusa T, Jarchum I, Chen YG, Iwai Y, Serreze DV, Steinman RM, Tarbell KV, DiLorenzo TP. Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice. Proc Natl Acad Sci U S A. 2008 Apr 29; 105(17):6374-9. PMID: 18430797.
      Citations: 76     Fields:    Translation:AnimalsCells
    61. Chaparro RJ, Burton AR, Serreze DV, Vignali DA, DiLorenzo TP. Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells. J Immunol Methods. 2008 Jun 01; 335(1-2):106-15. PMID: 18439618.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    62. Serreze DV, Choisy-Rossi CM, Grier AE, Holl TM, Chapman HD, Gahagan JR, Osborne MA, Zhang W, King BL, Brown A, Roopenian D, Marron MP. Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice. J Immunol. 2008 Mar 01; 180(5):3250-9. PMID: 18292549.
      Citations: 11     Fields:    Translation:AnimalsCells
    63. Chen YG, Driver JP, Silveira PA, Serreze DV. Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice. Immunogenetics. 2007 Sep; 59(9):705-12. PMID: 17619875.
      Citations: 10     Fields:    Translation:AnimalsCells
    64. Jarchum I, Baker JC, Yamada T, Takaki T, Marron MP, Serreze DV, DiLorenzo TP. In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice. Diabetes. 2007 Oct; 56(10):2551-60. PMID: 17620420.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    65. Serreze DV, Marron MP, Dilorenzo TP. "Humanized" HLA transgenic NOD mice to identify pancreatic beta cell autoantigens of potential clinical relevance to type 1 diabetes. Ann N Y Acad Sci. 2007 Apr; 1103:103-11. PMID: 17376821.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    66. Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet. 2007 Mar; 39(3):329-37. PMID: 17277778.
      Citations: 182     Fields:    Translation:AnimalsCells
    67. Chen YG, Silveira PA, Osborne MA, Chapman HD, Serreze DV. Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype. Diabetes. 2007 Feb; 56(2):424-30. PMID: 17259387.
      Citations: 3     Fields:    Translation:AnimalsCells
    68. Silveira PA, Serreze DV, Grey ST. Invasion of the killer B's in type 1 diabetes. Front Biosci. 2007 Jan 01; 12:2183-93. PMID: 17127455.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    69. Razavi R, Chan Y, Afifiyan FN, Liu XJ, Wan X, Yantha J, Tsui H, Tang L, Tsai S, Santamaria P, Driver JP, Serreze D, Salter MW, Dosch HM. TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes. Cell. 2006 Dec 15; 127(6):1123-35. PMID: 17174891.
      Citations: 138     Fields:    Translation:AnimalsCells
    70. Serreze DV, Osborne MA, Chen YG, Chapman HD, Pearson T, Brehm MA, Greiner DL. Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression. J Immunol. 2006 Nov 15; 177(10):6675-84. PMID: 17082580.
      Citations: 10     Fields:    Translation:AnimalsCells
    71. Silveira PA, Chapman HD, Stolp J, Johnson E, Cox SL, Hunter K, Wicker LS, Serreze DV. Genes within the Idd5 and Idd9/11 diabetes susceptibility loci affect the pathogenic activity of B cells in nonobese diabetic mice. J Immunol. 2006 Nov 15; 177(10):7033-41. PMID: 17082619.
      Citations: 16     Fields:    Translation:AnimalsCells
    72. Chen YG, Chen J, Osborne MA, Chapman HD, Besra GS, Porcelli SA, Leiter EH, Wilson SB, Serreze DV. CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. J Immunol. 2006 Sep 01; 177(5):2939-47. PMID: 16920929.
      Citations: 15     Fields:    Translation:AnimalsCells
    73. Chen J, Chen YG, Reifsnyder PC, Schott WH, Lee CH, Osborne M, Scheuplein F, Haag F, Koch-Nolte F, Serreze DV, Leiter EH. Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. J Immunol. 2006 Apr 15; 176(8):4590-9. PMID: 16585549.
      Citations: 31     Fields:    Translation:AnimalsCells
    74. Takaki T, Marron MP, Mathews CE, Guttmann ST, Bottino R, Trucco M, DiLorenzo TP, Serreze DV. HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol. 2006 Mar 01; 176(5):3257-65. PMID: 16493087.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    75. Lee CH, Chen YG, Chen J, Reifsnyder PC, Serreze DV, Clare-Salzler M, Rodriguez M, Wasserfall C, Atkinson MA, Leiter EH. Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis. Diabetes. 2006 Jan; 55(1):171-8. PMID: 16380490.
      Citations: 10     Fields:    Translation:AnimalsCells
    76. Serreze DV, Chen YG. Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans. Trends Immunol. 2005 Nov; 26(11):603-7. PMID: 16140038.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    77. Xu BY, Yang H, Serreze DV, MacIntosh R, Yu W, Wright JR. Rapid destruction of encapsulated islet xenografts by NOD mice is CD4-dependent and facilitated by B-cells: innate immunity and autoimmunity do not play significant roles. Transplantation. 2005 Aug 15; 80(3):402-9. PMID: 16082337.
      Citations: 6     Fields:    Translation:AnimalsCells
    78. Pomerleau DP, Bagley RJ, Serreze DV, Mathews CE, Leiter EH. Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex. Diabetes. 2005 May; 54(5):1603-6. PMID: 15855353.
      Citations: 11     Fields:    Translation:Animals
    79. DiLorenzo TP, Serreze DV. The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice. Immunol Rev. 2005 Apr; 204:250-63. PMID: 15790363.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    80. Chen YG, Choisy-Rossi CM, Holl TM, Chapman HD, Besra GS, Porcelli SA, Shaffer DJ, Roopenian D, Wilson SB, Serreze DV. Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes. J Immunol. 2005 Feb 01; 174(3):1196-204. PMID: 15661873.
      Citations: 42     Fields:    Translation:AnimalsCells
    81. Gordon EJ, Wicker LS, Peterson LB, Serreze DV, Markees TG, Shultz LD, Rossini AA, Greiner DL, Mordes JP. Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice. Diabetes. 2005 Jan; 54(1):107-15. PMID: 15616017.
      Citations: 6     Fields:    Translation:Animals
    82. Serreze DV, Wasserfall C, Ottendorfer EW, Stalvey M, Pierce MA, Gauntt C, O'Donnell B, Flanagan JB, Campbell-Thompson M, Ellis TM, Atkinson MA. Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon. J Virol. 2005 Jan; 79(2):1045-52. PMID: 15613333.
      Citations: 34     Fields:    Translation:AnimalsCells
    83. Pierce MA, Svetlanov A, Horwitz MS, Serreze DV. Adenovirus early region 3 transgenes expressed in beta cells prevent autoimmune diabetes in nonobese diabetic mice: effects of deleting the adenovirus death protein 11.6K. J Virol. 2005 Jan; 79(1):619-21. PMID: 15596856.
      Citations: 1     Fields:    Translation:AnimalsCells
    84. Lieberman SM, Takaki T, Han B, Santamaria P, Serreze DV, DiLorenzo TP. Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase. J Immunol. 2004 Dec 01; 173(11):6727-34. PMID: 15557165.
      Citations: 52     Fields:    Translation:AnimalsCells
    85. Fallarino F, Bianchi R, Orabona C, Vacca C, Belladonna ML, Fioretti MC, Serreze DV, Grohmann U, Puccetti P. CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J Exp Med. 2004 Oct 18; 200(8):1051-62. PMID: 15492127.
      Citations: 57     Fields:    Translation:AnimalsCells
    86. Choisy-Rossi CM, Holl TM, Pierce MA, Chapman HD, Serreze DV. Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience. J Immunol. 2004 Sep 15; 173(6):3791-800. PMID: 15356126.
      Citations: 15     Fields:    Translation:AnimalsCells
    87. Takaki T, Lieberman SM, Holl TM, Han B, Santamaria P, Serreze DV, DiLorenzo TP. Requirement for both H-2Db and H-2Kd for the induction of diabetes by the promiscuous CD8+ T cell clonotype AI4. J Immunol. 2004 Aug 15; 173(4):2530-41. PMID: 15294969.
      Citations: 12     Fields:    Translation:AnimalsCells
    88. Pearson T, Weiser P, Markees TG, Serreze DV, Wicker LS, Peterson LB, Cumisky AM, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3. Diabetes. 2004 Aug; 53(8):1972-8. PMID: 15277375.
      Citations: 10     Fields:    Translation:Animals
    89. Silveira PA, Dombrowsky J, Johnson E, Chapman HD, Nemazee D, Serreze DV. B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice. J Immunol. 2004 Apr 15; 172(8):5086-94. PMID: 15067092.
      Citations: 28     Fields:    Translation:AnimalsCells
    90. Serreze DV, Holl TM, Marron MP, Graser RT, Johnson EA, Choisy-Rossi C, Slattery RM, Lieberman SM, DiLorenzo TP. MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice. J Immunol. 2004 Jan 15; 172(2):871-9. PMID: 14707058.
      Citations: 11     Fields:    Translation:AnimalsCells
    91. Serreze DV, Roopenian DC. Was there type 1 diabetes in the Olduvai Gorge? Adv Exp Med Biol. 2004; 552:322-5. PMID: 15622973.
      Citations:    Fields:    Translation:HumansAnimals
    92. Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms? Ann N Y Acad Sci. 2003 Nov; 1005:148-56. PMID: 14679049.
      Citations: 11     Fields:    Translation:Animals
    93. Mathews CE, Graser RT, Bagley RJ, Caldwell JW, Li R, Churchill GA, Serreze DV, Leiter EH. Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress. Immunogenetics. 2003 Oct; 55(7):491-6. PMID: 14513297.
      Citations: 25     Fields:    Translation:Animals
    94. Serreze DV, Leiter EH. Tracking autoimmune T cells in diabetes. J Clin Invest. 2003 Sep; 112(6):826-8. PMID: 12975466.
      Citations:    Fields:    Translation:HumansAnimalsCells
    95. Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice. Rev Endocr Metab Disord. 2003 Sep; 4(3):255-61. PMID: 14501176.
      Citations: 2     Fields:    Translation:HumansAnimals
    96. Pearson T, Markees TG, Serreze DV, Pierce MA, Marron MP, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol. 2003 Jul 01; 171(1):185-95. PMID: 12816997.
      Citations: 31     Fields:    Translation:AnimalsCells
    97. Lieberman SM, Evans AM, Han B, Takaki T, Vinnitskaya Y, Caldwell JA, Serreze DV, Shabanowitz J, Hunt DF, Nathenson SG, Santamaria P, DiLorenzo TP. Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8384-8. PMID: 12815107.
      Citations: 168     Fields:    Translation:AnimalsCells
    98. Mo JS, Anderson MG, Gregory M, Smith RS, Savinova OV, Serreze DV, Ksander BR, Streilein JW, John SW. By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma. J Exp Med. 2003 May 19; 197(10):1335-44. PMID: 12756269.
      Citations: 50     Fields:    Translation:AnimalsCells
    99. Pierce MA, Chapman HD, Post CM, Svetlanov A, Efrat S, Horwitz M, Serreze DV. Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice. Diabetes. 2003 May; 52(5):1119-27. PMID: 12716741.
      Citations: 8     Fields:    Translation:AnimalsCells
    100. Serreze DV, Pierce MA, Post CM, Chapman HD, Savage H, Bronson RT, Rothman PB, Cox GA. Paralytic autoimmune myositis develops in nonobese diabetic mice made Th1 cytokine-deficient by expression of an IFN-gamma receptor beta-chain transgene. J Immunol. 2003 Mar 01; 170(5):2742-9. PMID: 12594305.
      Citations: 1     Fields:    Translation:AnimalsCells
    101. Pearson T, Markees TG, Wicker LS, Serreze DV, Peterson LB, Mordes JP, Rossini AA, Greiner DL. NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction. Diabetes. 2003 Feb; 52(2):321-6. PMID: 12540603.
      Citations: 27     Fields:    Translation:Animals
    102. Silveira PA, Johnson E, Chapman HD, Bui T, Tisch RM, Serreze DV. The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors. Eur J Immunol. 2002 Dec; 32(12):3657-66. PMID: 12516557.
      Citations: 73     Fields:    Translation:AnimalsCells
    103. DiLorenzo TP, Lieberman SM, Takaki T, Honda S, Chapman HD, Santamaria P, Serreze DV, Nathenson SG. During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities. Clin Immunol. 2002 Dec; 105(3):332-41. PMID: 12498815.
      Citations: 16     Fields:    Translation:AnimalsCells
    104. Marron MP, Graser RT, Chapman HD, Serreze DV. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13753-8. PMID: 12361980.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    105. Bonifacio E, Atkinson M, Eisenbarth G, Serreze D, Kay TW, Lee-Chan E, Singh B. International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: analyzing target autoantigens of humoral immunity in nonobese diabetic mice. Ann N Y Acad Sci. 2002 Apr; 958:1-2. PMID: 12021078.
      Citations: 2     Fields:    Translation:HumansAnimals
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