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Last Name
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Leonard Donald Shultz PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressThe Jackson Laboratory
600 Main Street
Bar Harbor ME 04069
Phone207-288-6405
vCardDownload vCard
    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionDiabetes

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentImmunology and Virology


    Collapse Biography 
    Collapse education and training
    Northeastern University, Boston, MA, United StatesBABiology
    University of Massachusetts Amherst, Amherst, MA, United StatesPHDMedical MicroBiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Youngblood BA, Brock EC, Leung J, Falahati R, Bryce PJ, Bright J, Williams J, Shultz LD, Greiner DL, Brehm MA, Bebbington C, Tomasevic N. AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice. Int Arch Allergy Immunol. 2019 Aug 09; 1-12. PMID: 31401630.
      View in: PubMed
    2. Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Zappasodi R, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM. Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. J Immunother Cancer. 2019 Jul 04; 7(1):167. PMID: 31272507.
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    3. Allen TM, Brehm MA, Bridges S, Ferguson S, Kumar P, Mirochnitchenko O, Palucka K, Pelanda R, Sanders-Beer B, Shultz LD, Su L, PrabhuDas M. Humanized immune system mouse models: progress, challenges and opportunities. Nat Immunol. 2019 Jun 03. PMID: 31160798.
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    4. Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM. Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. J Immunother Cancer. 2019 May 22; 7(1):131. PMID: 31113486.
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    5. Li P, Gong Z, Shultz LD, Ren G. Mesenchymal Stem Cells: from Regeneration to Cancer. Pharmacol Ther. 2019 Apr 15. PMID: 30998940.
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    6. Matsuda M, Ono R, Iyoda T, Endo T, Iwasaki M, Tomizawa-Murasawa M, Saito Y, Kaneko A, Shimizu K, Yamada D, Ogonuki N, Watanabe T, Nakayama M, Koseki Y, Kezuka-Shiotani F, Hasegawa T, Yabe H, Kato S, Ogura A, Shultz LD, Ohara O, Taniguchi M, Koseki H, Fujii SI, Ishikawa F. Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice. Life Sci Alliance. 2019 Apr; 2(2). PMID: 30936185.
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    7. Shultz LD, Keck J, Burzenski L, Jangalwe S, Vaidya S, Greiner DL, Brehm MA. Humanized mouse models of immunological diseases and precision medicine. Mamm Genome. 2019 Mar 07. PMID: 30847553.
      View in: PubMed
    8. Ono R, Watanabe T, Kawakami E, Iwasaki M, Tomizawa-Murasawa M, Matsuda M, Najima Y, Takagi S, Fujiki S, Sato R, Mochizuki Y, Yoshida H, Sato K, Yabe H, Kato S, Saito Y, Taniguchi S, Shultz LD, Ohara O, Amagai M, Koseki H, Ishikawa F. Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model. EBioMedicine. 2019 Feb 13. PMID: 30772305.
      View in: PubMed
    9. Gawron MA, Duval M, Carbone C, Jaiswal S, Wallace A, Martin JC, Dauphin A, Brehm MA, Greiner DL, Shultz LD, Luban J, Cavacini LA. Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1. J Immunol. 2018 Dec 28. PMID: 30593536.
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    10. Bahmani B, Uehara M, Ordikhani F, Li X, Jiang L, Banouni N, Ichimura T, Kasinath V, Eskandari SK, Annabi N, Bromberg JS, Shultz LD, Greiner DL, Abdi R. Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery. EBioMedicine. 2018 Nov 26. PMID: 30497977.
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    11. Saunders DC, Brissova M, Phillips N, Shrestha S, Walker JT, Aramandla R, Poffenberger G, Flaherty DK, Weller KP, Pelletier J, Cooper T, Goff MT, Virostko J, Shostak A, Dean ED, Greiner DL, Shultz LD, Prasad N, Levy SE, Carnahan RH, Dai C, Sévigny J, Powers AC. Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic ß Cells for In Vitro and In Vivo Analysis. Cell Metab. 2018 Nov 12. PMID: 30449685.
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    12. Brehm MA, Kenney LL, Wiles MV, Low BE, Tisch RM, Burzenski L, Mueller C, Greiner DL, Shultz LD. Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression. FASEB J. 2018 Nov 01; fj201800636R. PMID: 30383447.
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    13. Hosur V, Farley ML, Low BE, Burzenski LM, Shultz LD, Wiles MV. RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models? Front Genet. 2018; 9:233. PMID: 30022999.
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    14. Hosur V, Farley ML, Burzenski LM, Shultz LD, Wiles MV. ADAM17 is essential for ectodomain shedding of the EGF-receptor ligand amphiregulin. FEBS Open Bio. 2018 Apr; 8(4):702-710. PMID: 29632822.
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    15. Brissova M, Haliyur R, Saunders D, Shrestha S, Dai C, Blodgett DM, Bottino R, Campbell-Thompson M, Aramandla R, Poffenberger G, Lindner J, Pan FC, von Herrath MG, Greiner DL, Shultz LD, Sanyoura M, Philipson LH, Atkinson M, Harlan DM, Levy SE, Prasad N, Stein R, Powers AC. a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes. Cell Rep. 2018 Mar 06; 22(10):2667-2676. PMID: 29514095.
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    16. Wang M, Yao LC, Cheng M, Cai D, Martinek J, Pan CX, Shi W, Ma AH, De Vere White RW, Airhart S, Liu ET, Banchereau J, Brehm MA, Greiner DL, Shultz LD, Palucka K, Keck JG. Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. FASEB J. 2018 Mar; 32(3):1537-1549. PMID: 29146734.
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    17. Hua L, Shi J, Shultz LD, Ren G. Genetic Models of Macrophage Depletion. Methods Mol Biol. 2018; 1784:243-258. PMID: 29761404.
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    18. Hosur V, Lyons BL, Burzenski LM, Shultz LD. Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease. BMC Res Notes. 2017 Nov 07; 10(1):573. PMID: 29116018.
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    19. Saito Y, Mochizuki Y, Ogahara I, Watanabe T, Hogdal L, Takagi S, Sato K, Kaneko A, Kajita H, Uchida N, Fukami T, Shultz LD, Taniguchi S, Ohara O, Letai AG, Ishikawa F. Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways. Sci Transl Med. 2017 Oct 25; 9(413). PMID: 29070697.
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    20. Durost PA, Aryee KE, Manzoor F, Tisch RM, Mueller C, Jurczyk A, Shultz LD, Brehm MA. Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice. Hum Gene Ther. 2018 Mar; 29(3):352-365. PMID: 28826231.
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    21. Borel F, Tang Q, Gernoux G, Greer C, Wang Z, Barzel A, Kay MA, Shultz LD, Greiner DL, Flotte TR, Brehm MA, Mueller C. Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of a-1 Antitrypsin Deficiency. Mol Ther. 2017 Nov 01; 25(11):2477-2489. PMID: 29032169.
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    22. Dai C, Hang Y, Shostak A, Poffenberger G, Hart N, Prasad N, Phillips N, Levy SE, Greiner DL, Shultz LD, Bottino R, Kim SK, Powers AC. Age-dependent human ß cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. J Clin Invest. 2017 Oct 02; 127(10):3835-3844. PMID: 28920919.
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    23. Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC. Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Rep. 2017 Aug 22; 20(8):1978-1990. PMID: 28834758.
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    24. Burack WR, Spence JM, Spence JP, Spence SA, Rock PJ, Shenoy GN, Shultz LD, Bankert RB, Bernstein SH. Patient-derived xenografts of low-grade B-cell lymphomas demonstrate roles of the tumor microenvironment. Blood Adv. 2017 Jul 11; 1(16):1263-1273. PMID: 29296768.
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    25. Hosur V, Low BE, Shultz LD, Wiles MV. Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis. Biol Open. 2017 Jun 27. PMID: 28655741.
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    26. Lee J, Dykstra B, Spencer JA, Kenney LL, Greiner DL, Shultz LD, Brehm MA, Lin CP, Sackstein R, Rossi DJ. mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors. J Clin Invest. 2017 May 08. PMID: 28481220.
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    27. Verma MK, Clemens J, Burzenski L, Sampson SB, Brehm MA, Greiner DL, Shultz LD. A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo. J Immunol Methods. 2017 Apr 06. PMID: 28390927.
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    28. Hosur V, Low BE, Avery C, Shultz LD, Wiles MV. Development of Humanized Mice in the Age of Genome Editing. J Cell Biochem. 2017 Mar 22. PMID: 28332231.
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    29. Hosur V, Burzenski LM, Stearns TM, Farley ML, Sundberg JP, Wiles MV, Shultz LD. Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing. Exp Mol Pathol. 2017 Mar 04. PMID: 28268192.
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    30. Miller PH, Rabu G, MacAldaz M, Knapp DJ, Cheung AM, Dhillon K, Nakamichi N, Beer PA, Shultz LD, Humphries RK, Eaves CJ. Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit immunodeficient mice. Exp Hematol. 2017 Jan 10. PMID: 28087429.
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    31. Walsh NC, Kenney LL, Jangalwe S, Aryee KE, Greiner DL, Brehm MA, Shultz LD. Humanized Mouse Models of Clinical Disease. Annu Rev Pathol. 2016 Dec 05. PMID: 27959627.
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    32. Moser J, van Ark J, van Dijk MC, Greiner DL, Shultz LD, van Goor H, Hillebrands JL. Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury. Sci Rep. 2016 Oct 19; 6:35387. PMID: 27759053.
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    33. Jangalwe S, Shultz LD, Mathew A, Brehm MA. Improved B cell development in humanized NOD-scid IL2R?null mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3. Immun Inflamm Dis. 2016 Dec; 4(4):427-440. PMID: 27980777.
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    34. Cheng F, Twardowski L, Reifenberg K, Winter K, Canisius A, Pross E, Fan J, Schmitt E, Shultz LD, Lackner KJ, Torzewski M. Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice. PLoS One. 2016; 11(8):e0157311. PMID: 27564380.
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    35. Boudreau JE, Liu XR, Zhao Z, Zhang A, Shultz LD, Greiner DL, Dupont B, Hsu KC. Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I. Immunity. 2016 Aug 16; 45(2):280-91. PMID: 27496730.
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    36. Ali R, Babad J, Follenzi A, Gebe JA, Brehm MA, Nepom GT, Shultz LD, Greiner DL, DiLorenzo TP. Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease. Immunology. 2016 Aug; 148(4):339-51. PMID: 27124592.
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    37. Mercado-Lubo R, Zhang Y, Zhao L, Rossi K, Wu X, Zou Y, Castillo A, Leonard J, Bortell R, Greiner DL, Shultz LD, Han G, McCormick BA. A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours. Nat Commun. 2016 Jul 25; 7:12225. PMID: 27452236.
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    38. Dai C, Kayton NS, Shostak A, Poffenberger G, Cyphert HA, Aramandla R, Thompson C, Papagiannis IG, Emfinger C, Shiota M, Stafford JM, Greiner DL, Herrera PL, Shultz LD, Stein R, Powers AC. Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. J Clin Invest. 2016 May 2; 126(5):1857-70. PMID: 27064285.
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    39. Liu ET, Bult CJ, Shultz LD. Patient-Derived Tumor Xenografts: Why Now? JAMA Oncol. 2016 Apr 07. PMID: 27055176.
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    40. Bryce PJ, Falahati R, Kenney LL, Leung J, Bebbington C, Tomasevic N, Krier RA, Hsu CL, Shultz LD, Greiner DL, Brehm MA. Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis. J Allergy Clin Immunol. 2016 Sep; 138(3):769-79. PMID: 27139822.
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    41. Serr I, Fürst RW, Achenbach P, Scherm MG, Gökmen F, Haupt F, Sedlmeier EM, Knopff A, Shultz L, Willis RA, Ziegler AG, Daniel C. Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice. Nat Commun. 2016 Mar 15; 7:10991. PMID: 26975663.
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    42. Goel HL, Pursell B, Shultz LD, Greiner DL, Brekken RA, Vander Kooi CW, Mercurio AM. P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer. Cell Rep. 2016 Mar 08; 14(9):2193-208. PMID: 26923603.
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    43. Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA. Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary. AIDS Res Hum Retroviruses. 2016 Feb; 32(2):109-19. PMID: 26670361.
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    44. Hasgur S, Aryee KE, Shultz LD, Greiner DL, Brehm MA. Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells. Methods Mol Biol. 2016; 1438:67-78. PMID: 27150084.
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    45. Najima Y, Tomizawa-Murasawa M, Saito Y, Watanabe T, Ono R, Ochi T, Suzuki N, Fujiwara H, Ohara O, Shultz LD, Yasukawa M, Ishikawa F. Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice. Blood. 2016 Feb 11; 127(6):722-34. PMID: 26702062.
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    46. Friedline RH, Ko HJ, Jung DY, Lee Y, Bortell R, Dagdeviren S, Patel PR, Hu X, Inashima K, Kearns C, Tsitsilianos N, Shafiq U, Shultz LD, Lee KW, Greiner DL, Kim JK. Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance. FASEB J. 2016 Mar; 30(3):1328-38. PMID: 26644351.
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    47. Kenney LL, Shultz LD, Greiner DL, Brehm MA. Humanized Mouse Models for Transplant Immunology. Am J Transplant. 2016 Feb; 16(2):389-97. PMID: 26588186.
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    48. Jurczyk A, Nowosielska A, Przewozniak N, Aryee KE, DiIorio P, Blodgett D, Yang C, Campbell-Thompson M, Atkinson M, Shultz L, Rittenhouse A, Harlan D, Greiner D, Bortell R. Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ß-cell function via glycogen synthase kinase-3ß. FASEB J. 2016 Feb; 30(2):983-93. PMID: 26546129.
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    49. Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P, Mothes W. Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Science. 2015 Oct 30; 350(6260):563-7. PMID: 26429886.
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    50. Li S, Ling C, Zhong L, Li M, Su Q, He R, Tang Q, Greiner DL, Shultz LD, Brehm MA, Flotte TR, Mueller C, Srivastava A, Gao G. Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors. Mol Ther. 2015 Dec; 23(12):1867-76. PMID: 26403887.
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    51. Yang C, Loehn M, Jurczyk A, Przewozniak N, Leehy L, Herrera PL, Shultz LD, Greiner DL, Harlan DM, Bortell R. Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets. Diabetes Metab Syndr Obes. 2015; 8:387-98. PMID: 26316789.
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    52. Presa M, Chen YG, Grier AE, Leiter EH, Brehm MA, Greiner DL, Shultz LD, Serreze DV. The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice. J Immunol. 2015 Oct 01; 195(7):3011-9. PMID: 26283479.
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    53. Samanta S, Sun H, Goel HL, Pursell B, Chang C, Khan A, Greiner DL, Cao S, Lim E, Shultz LD, Mercurio AM. IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG. Oncogene. 2016 Mar 3; 35(9):1111-21. PMID: 25982283.
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    54. Crescenzo R, Abate F, Lasorsa E, Tabbo' F, Gaudiano M, Chiesa N, Di Giacomo F, Spaccarotella E, Barbarossa L, Ercole E, Todaro M, Boi M, Acquaviva A, Ficarra E, Novero D, Rinaldi A, Tousseyn T, Rosenwald A, Kenner L, Cerroni L, Tzankov A, Ponzoni M, Paulli M, Weisenburger D, Chan WC, Iqbal J, Piris MA, Zamo' A, Ciardullo C, Rossi D, Gaidano G, Pileri S, Tiacci E, Falini B, Shultz LD, Mevellec L, Vialard JE, Piva R, Bertoni F, Rabadan R, Inghirami G. Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma. Cancer Cell. 2015 Apr 13; 27(4):516-32. PMID: 25873174.
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    55. Babad J, Mukherjee G, Follenzi A, Ali R, Roep BO, Shultz LD, Santamaria P, Yang OO, Goldstein H, Greiner DL, DiLorenzo TP. Generation of ß cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice. Clin Exp Immunol. 2015 Mar; 179(3):398-413. PMID: 25302633.
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    56. Tang Z, Dai S, He Y, Doty RA, Shultz LD, Sampson SB, Dai C. MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1. Cell. 2015 Feb 12; 160(4):729-44. PMID: 25679764.
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    57. Chang C, Goel HL, Gao H, Pursell B, Shultz LD, Greiner DL, Ingerpuu S, Patarroyo M, Cao S, Lim E, Mao J, McKee KK, Yurchenco PD, Mercurio AM. A laminin 511 matrix is regulated by TAZ and functions as the ligand for the a6Bß1 integrin to sustain breast cancer stem cells. Genes Dev. 2015 Jan 01; 29(1):1-6. PMID: 25561492.
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    58. Aoki Y, Watanabe T, Saito Y, Kuroki Y, Hijikata A, Takagi M, Tomizawa D, Eguchi M, Eguchi-Ishimae M, Kaneko A, Ono R, Sato K, Suzuki N, Fujiki S, Koh K, Ishii E, Shultz LD, Ohara O, Mizutani S, Ishikawa F. Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia. Blood. 2015 Feb 5; 125(6):967-80. PMID: 25538041.
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    59. Abate F, Todaro M, van der Krogt JA, Boi M, Landra I, Machiorlatti R, Tabbò F, Messana K, Abele C, Barreca A, Novero D, Gaudiano M, Aliberti S, Di Giacomo F, Tousseyn T, Lasorsa E, Crescenzo R, Bessone L, Ficarra E, Acquaviva A, Rinaldi A, Ponzoni M, Longo DL, Aime S, Cheng M, Ruggeri B, Piccaluga PP, Pileri S, Tiacci E, Falini B, Pera-Gresely B, Cerchietti L, Iqbal J, Chan WC, Shultz LD, Kwee I, Piva R, Wlodarska I, Rabadan R, Bertoni F, Inghirami G. A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation. Leukemia. 2015 Jun; 29(6):1390-401. PMID: 25533804; PMCID: PMC4864432.
    60. Gallagher GR, Brehm MA, Finberg RW, Barton BA, Shultz LD, Greiner DL, Bortell R, Wang JP. Viral infection of engrafted human islets leads to diabetes. Diabetes. 2015 Apr; 64(4):1358-69. PMID: 25392246.
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    61. Jaiswal S, Smith K, Ramirez A, Woda M, Pazoles P, Shultz LD, Greiner DL, Brehm MA, Mathew A. Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice. Exp Biol Med (Maywood). 2015 Jan; 240(1):67-78. PMID: 25125497.
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    62. Barth BM, Keasey NR, Wang X, Shanmugavelandy SS, Rampal R, Hricik T, Cabot MC, Kester M, Wang HG, Shultz LD, Tallman MS, Levine RL, Loughran TP, Claxton DF. Engraftment of Human Primary Acute Myeloid Leukemia Defined by Integrated Genetic Profiling in NOD/SCID/IL2r?null Mice for Preclinical Ceramide-Based Therapeutic Evaluation. J Leuk (Los Angel). 2014 Sep; 2(3). PMID: 28239612.
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    63. Trabucco SE, Gerstein RM, Evens AM, Bradner JE, Shultz LD, Greiner DL, Zhang H. Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma. Clin Cancer Res. 2015 Jan 1; 21(1):113-22. PMID: 25009295.
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    64. Shultz LD, Goodwin N, Ishikawa F, Hosur V, Lyons BL, Greiner DL. Subcapsular transplantation of tissue in the kidney. Cold Spring Harb Protoc. 2014 Jul 01; 2014(7):737-40. PMID: 24987138.
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    65. Shultz LD, Goodwin N, Ishikawa F, Hosur V, Lyons BL, Greiner DL. Human cancer growth and therapy in immunodeficient mouse models. Cold Spring Harb Protoc. 2014 Jul 01; 2014(7):694-708. PMID: 24987146.
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    66. Hosur V, Johnson KR, Burzenski LM, Stearns TM, Maser RS, Shultz LD. Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):E2200-9. PMID: 24825892.
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    67. Maykel J, Liu JH, Li H, Shultz LD, Greiner DL, Houghton J. NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer. Dig Dis Sci. 2014 Jun; 59(6):1169-79. PMID: 24798995.
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    68. Goel HL, Gritsko T, Pursell B, Chang C, Shultz LD, Greiner DL, Norum JH, Toftgard R, Shaw LM, Mercurio AM. Regulated splicing of the a6 integrin cytoplasmic domain determines the fate of breast cancer stem cells. Cell Rep. 2014 May 8; 7(3):747-61. PMID: 24767994.
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    69. Brehm MA, Wiles MV, Greiner DL, Shultz LD. Generation of improved humanized mouse models for human infectious diseases. J Immunol Methods. 2014 Aug; 410:3-17. PMID: 24607601.
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    70. Knoechel B, Roderick JE, Williamson KE, Zhu J, Lohr JG, Cotton MJ, Gillespie SM, Fernandez D, Ku M, Wang H, Piccioni F, Silver SJ, Jain M, Pearson D, Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A, Stegmaier K, Kung AL, Root DE, Bradner JE, Aster JC, Kelliher MA, Bernstein BE. An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nat Genet. 2014 Apr; 46(4):364-70. PMID: 24584072.
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    71. Potter CS, Wang Z, Silva KA, Kennedy VE, Stearns TM, Burzenski L, Shultz LD, Hogenesch H, Sundberg JP. Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling. PLoS One. 2014; 9(1):e85666. PMID: 24465642.
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    72. Roderick JE, Tesell J, Shultz LD, Brehm MA, Greiner DL, Harris MH, Silverman LB, Sallan SE, Gutierrez A, Look AT, Qi J, Bradner JE, Kelliher MA. c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood. 2014 Feb 13; 123(7):1040-50. PMID: 24394663.
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    73. Aryee KE, Shultz LD, Brehm MA. Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development. Methods Mol Biol. 2014; 1185:267-78. PMID: 25062635.
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    74. Jurczyk A, Diiorio P, Brostowin D, Leehy L, Yang C, Urano F, Harlan DM, Shultz LD, Greiner DL, Bortell R. Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2r?(null) mice treated with alogliptin. Diabetes Metab Syndr Obes. 2013; 6:493-9. PMID: 24376359.
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    75. Lee J, Brehm MA, Greiner D, Shultz LD, Kornfeld H. Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice. BMC Immunol. 2013 Dec 07; 14:53. PMID: 24313934.
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    76. Covassin L, Jangalwe S, Jouvet N, Laning J, Burzenski L, Shultz LD, Brehm MA. Human immune system development and survival of non-obese diabetic (NOD)-scid IL2r?(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells. Clin Exp Immunol. 2013 Dec; 174(3):372-88. PMID: 23869841; PMCID: PMC3826304.
    77. Schleifman EB, McNeer NA, Jackson A, Yamtich J, Brehm MA, Shultz LD, Greiner DL, Kumar P, Saltzman WM, Glazer PM. Site-specific Genome Editing in PBMCs With PLGA Nanoparticle-delivered PNAs Confers HIV-1 Resistance in Humanized Mice. Mol Ther Nucleic Acids. 2013 Nov 19; 2:e135. PMID: 24253260.
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    78. Guendel I, Iordanskiy S, Van Duyne R, Kehn-Hall K, Saifuddin M, Das R, Jaworski E, Sampey GC, Senina S, Shultz L, Narayanan A, Chen H, Lepene B, Zeng C, Kashanchi F. Novel neuroprotective GSK-3ß inhibitor restricts Tat-mediated HIV-1 replication. J Virol. 2014 Jan; 88(2):1189-208. PMID: 24227837.
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    79. Brehm MA, Shultz LD, Luban J, Greiner DL. Overcoming current limitations in humanized mouse research. J Infect Dis. 2013 Nov; 208 Suppl 2:S125-30. PMID: 24151318.
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    80. Dou S, Wang Y, Barton B, Chen L, Rusckowski M, Shultz LD, Greiner DL, Liu G. Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach. Nucl Med Biol. 2014 Jan; 41(1):127-31. PMID: 24210286.
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    81. Jiménez-Díaz MB, Viera S, Ibáñez J, Mulet T, Magán-Marchal N, Garuti H, Gómez V, Cortés-Gil L, Martínez A, Ferrer S, Fraile MT, Calderón F, Fernández E, Shultz LD, Leroy D, Wilson DM, García-Bustos JF, Gamo FJ, Angulo-Barturen I. A new in vivo screening paradigm to accelerate antimalarial drug discovery. PLoS One. 2013; 8(6):e66967. PMID: 23825598.
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    82. Brehm MA, Jouvet N, Greiner DL, Shultz LD. Humanized mice for the study of infectious diseases. Curr Opin Immunol. 2013 Aug; 25(4):428-35. PMID: 23751490.
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    83. Yokota SJ, Facciponte JG, Kelleher RJ, Shultz LD, Loyall JL, Parsons RR, Odunsi K, Frelinger JG, Lord EM, Gerber SA, Balu-Iyer SV, Bankert RB. Changes in ovarian tumor cell number, tumor vasculature, and T cell function monitored in vivo using a novel xenograft model. Cancer Immun. 2013; 13:11. PMID: 23885217.
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    84. Saito Y, Yuki H, Kuratani M, Hashizume Y, Takagi S, Honma T, Tanaka A, Shirouzu M, Mikuni J, Handa N, Ogahara I, Sone A, Najima Y, Tomabechi Y, Wakiyama M, Uchida N, Tomizawa-Murasawa M, Kaneko A, Tanaka S, Suzuki N, Kajita H, Aoki Y, Ohara O, Shultz LD, Fukami T, Goto T, Taniguchi S, Yokoyama S, Ishikawa F. A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Sci Transl Med. 2013 Apr 17; 5(181):181ra52. PMID: 23596204.
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    85. Tanaka T, Fujita Y, Ueno M, Shultz LD, Yamashita T. Suppression of SHP-1 promotes corticospinal tract sprouting and functional recovery after brain injury. Cell Death Dis. 2013; 4:e567. PMID: 23559001.
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    86. Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. GLI1 regulates a novel neuropilin-2/a6ß1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med. 2013 Apr; 5(4):488-508. PMID: 23436775.
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    87. Hickey RD, Galivo F, Schug J, Brehm MA, Haft A, Wang Y, Benedetti E, Gu G, Magnuson MA, Shultz LD, Lagasse E, Greiner DL, Kaestner KH, Grompe M. Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Res. 2013 Jul; 11(1):503-15. PMID: 23562832.
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    88. Seymour R, Shirley BJ, Hogenesch H, Shultz LD, Sundberg JP. Loss of function of the mouse Sharpin gene results in Peyer's patch regression. PLoS One. 2013; 8(2):e55224. PMID: 23424624.
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    89. Zhang B, Li M, McDonald T, Holyoake TL, Moon RT, Campana D, Shultz L, Bhatia R. Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-ß-catenin signaling. Blood. 2013 Mar 7; 121(10):1824-38. PMID: 23299311.
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    90. Hosur V, Cox ML, Burzenski LM, Riding RL, Alley L, Lyons BL, Kavirayani A, Martin KA, Cox GA, Johnson KR, Shultz LD. Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in Hairpatches (Hpt) mice. PLoS One. 2013; 8(1):e53426. PMID: 23301070.
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    91. Unger WW, Pearson T, Abreu JR, Laban S, van der Slik AR, der Kracht SM, Kester MG, Serreze DV, Shultz LD, Griffioen M, Drijfhout JW, Greiner DL, Roep BO. Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice. PLoS One. 2012; 7(11):e49213. PMID: 23155466.
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    92. Wilson DW, Oslund KL, Lyons B, Foreman O, Burzenski L, Svenson KL, Chase TH, Shultz LD. Inflammatory dilated cardiomyopathy in Abcg5-deficient mice. Toxicol Pathol. 2013 Aug; 41(6):880-92. PMID: 23129576.
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    93. McNeer NA, Schleifman EB, Cuthbert A, Brehm M, Jackson A, Cheng C, Anandalingam K, Kumar P, Shultz LD, Greiner DL, Mark Saltzman W, Glazer PM. Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo. Gene Ther. 2013 Jun; 20(6):658-69. PMID: 23076379.
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    94. Shultz LD, Brehm MA, Garcia-Martinez JV, Greiner DL. Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol. 2012 Nov; 12(11):786-98. PMID: 23059428.
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    95. Jaiswal S, Pazoles P, Woda M, Shultz LD, Greiner DL, Brehm MA, Mathew A. Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice. Immunology. 2012 Jul; 136(3):334-43. PMID: 22384859.
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    96. Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, Shultz LD, Kiyono H, Ishikawa F. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2r?KO mice. J Immunol. 2012 Jun 15; 188(12):6145-55. PMID: 22611244.
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    97. Hosur V, Kavirayani A, Riefler J, Carney LM, Lyons B, Gott B, Cox GA, Shultz LD. Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma. Cancer Genet. 2012 May; 205(5):232-41. PMID: 22682622.
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    98. Bernstein JM, Lehman H, Lis M, Sands A, Wilding GE, Shultz L, Bankert R, Bobek L. Humanized mouse model used to monitor MUC gene expression in nasal polyps and to preclinically evaluate the efficacy of montelukast in reducing mucus production. Ann Otol Rhinol Laryngol. 2012 May; 121(5):307-16. PMID: 22724276.
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    99. Brehm MA, Powers AC, Shultz LD, Greiner DL. Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice. Cold Spring Harb Perspect Med. 2012 May; 2(5):a007757. PMID: 22553498.
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    100. Ippolito GC, Hoi KH, Reddy ST, Carroll SM, Ge X, Rogosch T, Zemlin M, Shultz LD, Ellington AD, Vandenberg CL, Georgiou G. Antibody repertoires in humanized NOD-scid-IL2R?(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One. 2012; 7(4):e35497. PMID: 22558161.
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    101. Brehm MA, Shultz LD. Human allograft rejection in humanized mice: a historical perspective. Cell Mol Immunol. 2012 May; 9(3):225-31. PMID: 22327213.
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    102. Liu G, Dou S, Akalin A, Rusckowski M, Streeter PR, Shultz LD, Greiner DL. Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol. 2012 Jul; 39(5):645-51. PMID: 22316614.
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    103. Robinson SN, Simmons PJ, Thomas MW, Brouard N, Javni JA, Trilok S, Shim JS, Yang H, Steiner D, Decker WK, Xing D, Shultz LD, Savoldo B, Dotti G, Bollard CM, Miller L, Champlin RE, Shpall EJ, Zweidler-McKay PA. Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2R?(null) mice. Exp Hematol. 2012 Jun; 40(6):445-56. PMID: 22306295.
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    104. Li M, Zhou M, Gong M, Ma J, Pei F, Beamer WG, Shultz LD, Hock JM, Yu X. A novel animal model for bone metastasis in human lung cancer. Oncol Lett. 2012 Apr 01; 3(4):802-806. PMID: 22740997.
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    105. Takagi S, Saito Y, Hijikata A, Tanaka S, Watanabe T, Hasegawa T, Mochizuki S, Kunisawa J, Kiyono H, Koseki H, Ohara O, Saito T, Taniguchi S, Shultz LD, Ishikawa F. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood. 2012 Mar 22; 119(12):2768-77. PMID: 22279057.
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    106. Brehm MA, Racki WJ, Leif J, Burzenski L, Hosur V, Wetmore A, Gott B, Herlihy M, Ignotz R, Dunn R, Shultz LD, Greiner DL. Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF. Blood. 2012 Mar 22; 119(12):2778-88. PMID: 22246028.
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    107. Duyne RV, Narayanan A, K-Hall K, Saifuddin M, Shultz L, Kashanchi F. Humanized mouse models of HIV-1 latency. Curr HIV Res. 2011 Dec 1; 9(8):595-605. PMID: 22211664.
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    108. Shultz LD, Brehm MA, Bavari S, Greiner DL. Humanized mice as a preclinical tool for infectious disease and biomedical research. Ann N Y Acad Sci. 2011 Dec; 1245:50-4. PMID: 22211979.
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    109. Greiner DL, Brehm MA, Hosur V, Harlan DM, Powers AC, Shultz LD. Humanized mice for the study of type 1 and type 2 diabetes. Ann N Y Acad Sci. 2011 Dec; 1245:55-8. PMID: 22211980.
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    110. Covassin L, Laning J, Abdi R, Langevin DL, Phillips NE, Shultz LD, Brehm MA. Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2r?(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease. Clin Exp Immunol. 2011 Nov; 166(2):269-80. PMID: 21985373.
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    111. Diiorio P, Jurczyk A, Yang C, Racki WJ, Brehm MA, Atkinson MA, Powers AC, Shultz LD, Greiner DL, Bortell R. Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice. Pancreas. 2011 Oct; 40(7):1147-9. PMID: 21926555.
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    112. Schleifman EB, Bindra R, Leif J, del Campo J, Rogers FA, Uchil P, Kutsch O, Shultz LD, Kumar P, Greiner DL, Glazer PM. Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids. Chem Biol. 2011 Sep 23; 18(9):1189-98. PMID: 21944757.
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    113. Bankert RB, Balu-Iyer SV, Odunsi K, Shultz LD, Kelleher RJ, Barnas JL, Simpson-Abelson M, Parsons R, Yokota SJ. Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis. PLoS One. 2011; 6(9):e24420. PMID: 21935406.
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    114. Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL. A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet. 2011 May; 7(5):e1002063. PMID: 21625621.
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    115. Whitfield-Larry F, Young EF, Talmage G, Fudge E, Azam A, Patel S, Largay J, Byrd W, Buse J, Calikoglu AS, Shultz LD, Frelinger JA. HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/?c(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells. Diabetes. 2011 Jun; 60(6):1726-33. PMID: 21521873.
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    116. Dorrell C, Grompe MT, Pan FC, Zhong Y, Canaday PS, Shultz LD, Greiner DL, Wright CV, Streeter PR, Grompe M. Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol Cell Endocrinol. 2011 Jun 6; 339(1-2):144-50. PMID: 21539888.
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    117. Liu G, Dou S, Cheng D, Leif J, Rusckowski M, Streeter PR, Shultz LD, Hnatowich DJ, Greiner DL. Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model. Mol Pharm. 2011 Jun 6; 8(3):767-73. PMID: 21361360.
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    118. Dash Y, Ramesh M, Kalyanasundaram R, Munirathinam G, Shultz LD, Rajan TV. Granuloma formation around filarial larvae triggered by host responses to an excretory/secretory antigen. Infect Immun. 2011 Feb; 79(2):838-45. PMID: 21078849.
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    119. Moriceau G, Ory B, Mitrofan L, Riganti C, Blanchard F, Brion R, Charrier C, Battaglia S, Pilet P, Denis MG, Shultz LD, Mönkkönen J, Rédini F, Heymann D. Zoledronic acid potentiates mTOR inhibition and abolishes the resistance of osteosarcoma cells to RAD001 (Everolimus): pivotal role of the prenylation process. Cancer Res. 2010 Dec 15; 70(24):10329-39. PMID: 20971812.
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    120. Foreman O, Kavirayani AM, Griffey SM, Reader R, Shultz LD. Opportunistic Bacterial Infections in Breeding Colonies of the NSG Mouse Strain. Vet Pathol. 2011 Mar; 48(2):495-9. PMID: 20817888.
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    121. Morisot S, Wayne AS, Bohana-Kashtan O, Kaplan IM, Gocke CD, Hildreth R, Stetler-Stevenson M, Walker RL, Davis S, Meltzer PS, Wheelan SJ, Brown P, Jones RJ, Shultz LD, Civin CI. High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias. Leukemia. 2010 Nov; 24(11):1859-66. PMID: 20739953.
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    122. Libby SJ, Brehm MA, Greiner DL, Shultz LD, McClelland M, Smith KD, Cookson BT, Karlinsey JE, Kinkel TL, Porwollik S, Canals R, Cummings LA, Fang FC. Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15589-94. PMID: 20713716.
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    123. Shultz LD, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M, Doi T, Sone A, Suzuki N, Fujiwara H, Yasukawa M, Ishikawa F. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13022-7. PMID: 20615947.
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    124. Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert A, Yang C, Herlihy M, Burzenski L, Gott B, Foreman O, Powers AC, Greiner DL, Shultz LD. Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice. Diabetes. 2010 Sep; 59(9):2265-70. PMID: 20570944.
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    125. Zhang B, Strauss AC, Chu S, Li M, Ho Y, Shiang KD, Snyder DS, Huettner CS, Shultz L, Holyoake T, Bhatia R. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell. 2010 May 18; 17(5):427-42. PMID: 20478526.
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    126. Brehm MA, Shultz LD, Greiner DL. Humanized mouse models to study human diseases. Curr Opin Endocrinol Diabetes Obes. 2010 Apr; 17(2):120-5. PMID: 20150806.
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    127. Racki WJ, Covassin L, Brehm M, Pino S, Ignotz R, Dunn R, Laning J, Graves SK, Rossini AA, Shultz LD, Greiner DL. NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection. Transplantation. 2010 Mar 15; 89(5):527-36. PMID: 20134397.
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    128. Saito Y, Uchida N, Tanaka S, Suzuki N, Tomizawa-Murasawa M, Sone A, Najima Y, Takagi S, Aoki Y, Wake A, Taniguchi S, Shultz LD, Ishikawa F. Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. Nat Biotechnol. 2010 Mar; 28(3):275-80. PMID: 20160717.
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    129. Saito Y, Kitamura H, Hijikata A, Tomizawa-Murasawa M, Tanaka S, Takagi S, Uchida N, Suzuki N, Sone A, Najima Y, Ozawa H, Wake A, Taniguchi S, Shultz LD, Ohara O, Ishikawa F. Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. Sci Transl Med. 2010 Feb 3; 2(17):17ra9. PMID: 20371479.
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    130. Brehm MA, Cuthbert A, Yang C, Miller DM, DiIorio P, Laning J, Burzenski L, Gott B, Foreman O, Kavirayani A, Herlihy M, Rossini AA, Shultz LD, Greiner DL. Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin Immunol. 2010 Apr; 135(1):84-98. PMID: 20096637.
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    131. Pino S, Brehm MA, Covassin-Barberis L, King M, Gott B, Chase TH, Wagner J, Burzenski L, Foreman O, Greiner DL, Shultz LD. Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease. Methods Mol Biol. 2010; 602:105-17. PMID: 20012395.
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    132. Subramanya S, Kim SS, Abraham S, Yao J, Kumar M, Kumar P, Haridas V, Lee SK, Shultz LD, Greiner D, N M, Shankar P. Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production. J Virol. 2010 Mar; 84(5):2490-501. PMID: 20015996.
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    133. Bernstein JM, Brooks SP, Lehman HK, Pope L, Sands A, Shultz LD, Bankert RB. Human nasal polyp microenvironments maintained in a viable and functional state as xenografts in NOD-scid IL2rgamma(null) mice. Ann Otol Rhinol Laryngol. 2009 Dec; 118(12):866-75. PMID: 20112521.
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    134. Tian X, Hexum MK, Penchev VR, Taylor RJ, Shultz LD, Kaufman DS. Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells. Stem Cells. 2009 Nov; 27(11):2675-85. PMID: 19711457.
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    135. Chase TH, Cox GA, Burzenski L, Foreman O, Shultz LD. Dysferlin deficiency and the development of cardiomyopathy in a mouse model of limb-girdle muscular dystrophy 2B. Am J Pathol. 2009 Dec; 175(6):2299-308. PMID: 19875504.
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    136. Chase TH, Lyons BL, Bronson RT, Foreman O, Donahue LR, Burzenski LM, Gott B, Lane P, Harris B, Ceglarek U, Thiery J, Wittenburg H, Thon JN, Italiano JE, Johnson KR, Shultz LD. The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia. Blood. 2010 Feb 11; 115(6):1267-76. PMID: 19846887.
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    137. Gori JL, Tian X, Swanson D, Gunther R, Shultz LD, McIvor RS, Kaufman DS. In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase. Gene Ther. 2010 Feb; 17(2):238-49. PMID: 19829316.
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    138. Jaiswal S, Pearson T, Friberg H, Shultz LD, Greiner DL, Rothman AL, Mathew A. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One. 2009 Oct 05; 4(10):e7251. PMID: 19802382.
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    139. Jiménez-Díaz MB, Mulet T, Viera S, Gómez V, Garuti H, Ibáñez J, Alvarez-Doval A, Shultz LD, Martínez A, Gargallo-Viola D, Angulo-Barturen I. Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes. Antimicrob Agents Chemother. 2009 Oct; 53(10):4533-6. PMID: 19596869.
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    140. King MA, Covassin L, Brehm MA, Racki W, Pearson T, Leif J, Laning J, Fodor W, Foreman O, Burzenski L, Chase TH, Gott B, Rossini AA, Bortell R, Shultz LD, Greiner DL. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol. 2009 Jul; 157(1):104-18. PMID: 19659776.
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    141. Miller DM, Thornley TB, Pearson T, Kruger AJ, Yamazaki M, Shultz LD, Welsh RM, Brehm MA, Rossini AA, Greiner DL. TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade. J Immunol. 2009 May 1; 182(9):5547-59. PMID: 19380803.
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    142. Unsinger J, McDonough JS, Shultz LD, Ferguson TA, Hotchkiss RS. Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol. 2009 Aug; 86(2):219-27. PMID: 19369639.
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    143. Chopra P, Diiorio P, Pino SC, Wilson SB, Phillips NE, Mordes JP, Rossini AA, Greiner DL, Shultz LD, Bortell R. Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat. In Vivo. 2009 Mar-Apr; 23(2):195-201. PMID: 19414403.
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    144. Harris MA, Yang H, Low BE, Mukherjee J, Mukherje J, Guha A, Bronson RT, Shultz LD, Israel MA, Yun K. Cancer stem cells are enriched in the side population cells in a mouse model of glioma. Cancer Res. 2008 Dec 15; 68(24):10051-9. PMID: 19074870.
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    145. King M, Pearson T, Rossini AA, Shultz LD, Greiner DL. Humanized mice for the study of type 1 diabetes and beta cell function. Ann N Y Acad Sci. 2008 Dec; 1150:46-53. PMID: 19120266.
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    146. Mangada J, Pearson T, Brehm MA, Wicker LS, Peterson LB, Shultz LD, Serreze DV, Rossini AA, Greiner DL. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes. 2009 Jan; 58(1):165-73. PMID: 18984741.
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    147. Agliano A, Martin-Padura I, Mancuso P, Marighetti P, Rabascio C, Pruneri G, Shultz LD, Bertolini F. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer. 2008 Nov 1; 123(9):2222-7. PMID: 18688847.
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    148. Mori K, Blanchard F, Charrier C, Battaglia S, Ando K, Duplomb L, Shultz LD, Redini F, Heymann D. Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk. Cancer Sci. 2008 Nov; 99(11):2170-6. PMID: 18957057.
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    149. Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15028-33. PMID: 18806225.
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    150. Schmidt MR, Appel MC, Giassi LJ, Greiner DL, Shultz LD, Woodland RT. Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice. PLoS One. 2008 Sep 11; 3(9):e3192. PMID: 18784835.
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    151. Pearson T, Shultz LD, Miller D, King M, Laning J, Fodor W, Cuthbert A, Burzenski L, Gott B, Lyons B, Foreman O, Rossini AA, Greiner DL. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol. 2008 Nov; 154(2):270-84. PMID: 18785974.
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    152. Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, Laouar A, Yao J, Haridas V, Habiro K, Yang YG, Jeong JH, Lee KY, Kim YH, Kim SW, Peipp M, Fey GH, Manjunath N, Shultz LD, Lee SK, Shankar P. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell. 2008 Aug 22; 134(4):577-86. PMID: 18691745.
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    153. Giassi LJ, Pearson T, Shultz LD, Laning J, Biber K, Kraus M, Woda BA, Schmidt MR, Woodland RT, Rossini AA, Greiner DL. Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice. Exp Biol Med (Maywood). 2008 Aug; 233(8):997-1012. PMID: 18653783.
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    154. le Viseur C, Hotfilder M, Bomken S, Wilson K, Röttgers S, Schrauder A, Rosemann A, Irving J, Stam RW, Shultz LD, Harbott J, Jürgens H, Schrappe M, Pieters R, Vormoor J. In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties. Cancer Cell. 2008 Jul 8; 14(1):47-58. PMID: 18598943.
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    155. Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL. A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia. 2008 Aug; 51(8):1449-56. PMID: 18563383.
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    156. Gaines P, Tien CW, Olins AL, Olins DE, Shultz LD, Carney L, Berliner N. Mouse neutrophils lacking lamin B-receptor expression exhibit aberrant development and lack critical functional responses. Exp Hematol. 2008 Aug; 36(8):965-76. PMID: 18550262.
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    157. Simpson-Abelson MR, Sonnenberg GF, Takita H, Yokota SJ, Conway TF, Kelleher RJ, Shultz LD, Barcos M, Bankert RB. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol. 2008 May 15; 180(10):7009-18. PMID: 18453623.
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    158. Pearson T, Greiner DL, Shultz LD. Creation of "humanized" mice to study human immunity. Curr Protoc Immunol. 2008 May; Chapter 15:Unit 15.21. PMID: 18491294.
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    159. Kong Y, Yoshida S, Saito Y, Doi T, Nagatoshi Y, Fukata M, Saito N, Yang SM, Iwamoto C, Okamura J, Liu KY, Huang XJ, Lu DP, Shultz LD, Harada M, Ishikawa F. CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL. Leukemia. 2008 Jun; 22(6):1207-13. PMID: 18418410.
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    160. Yamamoto T, Kaizu C, Kawasaki T, Hasegawa G, Umezu H, Ohashi R, Sakurada J, Jiang S, Shultz L, Naito M. Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletion. Cell Tissue Res. 2008 May; 332(2):245-56. PMID: 18335245.
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    161. Ishikawa F, Saito Y, Yoshida S, Harada M, Shultz LD. The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rgamma(null) mice. Curr Top Microbiol Immunol. 2008; 324:87-94. PMID: 18481454.
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    162. Pearson T, Greiner DL, Shultz LD. Humanized SCID mouse models for biomedical research. Curr Top Microbiol Immunol. 2008; 324:25-51. PMID: 18481451.
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    163. King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol. 2008 Mar; 126(3):303-14. PMID: 18096436.
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    164. Thornley TB, Phillips NE, Beaudette-Zlatanova BC, Markees TG, Bahl K, Brehm MA, Shultz LD, Kurt-Jones EA, Mordes JP, Welsh RM, Rossini AA, Greiner DL. Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance. J Immunol. 2007 Nov 15; 179(10):6620-9. PMID: 17982052.
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    165. Dash Y, Ramesh M, Greiner D, Shultz LD, Klei TR, Rajan TV. Determinants of memory in experimental filarial infections in mice. Parasite Immunol. 2007 Nov; 29(11):567-74. PMID: 17944746.
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    166. Ishikawa F, Yoshida S, Saito Y, Hijikata A, Kitamura H, Tanaka S, Nakamura R, Tanaka T, Tomiyama H, Saito N, Fukata M, Miyamoto T, Lyons B, Ohshima K, Uchida N, Taniguchi S, Ohara O, Akashi K, Harada M, Shultz LD. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol. 2007 Nov; 25(11):1315-21. PMID: 17952057.
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    167. Ramesh M, Paciorkowski N, Dash Y, Shultz L, Rajan TV. Acute but not chronic macrophage recruitment in filarial infections in mice is dependent on C-C chemokine ligand 2. Parasite Immunol. 2007 Aug; 29(8):395-404. PMID: 17650181.
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    168. Ishikawa F, Niiro H, Iino T, Yoshida S, Saito N, Onohara S, Miyamoto T, Minagawa H, Fujii S, Shultz LD, Harada M, Akashi K. The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways. Blood. 2007 Nov 15; 110(10):3591-660. PMID: 17664352.
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    169. Yamazaki M, Pearson T, Brehm MA, Miller DM, Mangada JA, Markees TG, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice. Am J Transplant. 2007 Jul; 7(7):1710-21. PMID: 17564635.
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    170. Seymour RE, Hasham MG, Cox GA, Shultz LD, Hogenesch H, Roopenian DC, Sundberg JP. Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. Genes Immun. 2007 Jul; 8(5):416-21. PMID: 17538631.
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    171. King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson M, Wasserfall C, Herold K, Mordes JP, Rossini AA, Greiner DL. Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity. Ann N Y Acad Sci. 2007 Apr; 1103:90-3. PMID: 17376822.
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    172. Shultz LD, Pearson T, King M, Giassi L, Carney L, Gott B, Lyons B, Rossini AA, Greiner DL. Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research. Ann N Y Acad Sci. 2007 Apr; 1103:77-89. PMID: 17332083.
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    173. Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol. 2007 Feb; 7(2):118-30. PMID: 17259968.
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    174. Yoshino M, Yamazaki H, Shultz LD, Hayashi S. Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes. Int Immunol. 2006 Nov; 18(11):1541-8. PMID: 16966493.
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    175. Meyerrose TE, De Ugarte DA, Hofling AA, Herrbrich PE, Cordonnier TD, Shultz LD, Eagon JC, Wirthlin L, Sands MS, Hedrick MA, Nolta JA. In vivo distribution of human adipose-derived mesenchymal stem cells in novel xenotransplantation models. Stem Cells. 2007 Jan; 25(1):220-7. PMID: 16960135.
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    176. Adachi Y, Oyaizu H, Taketani S, Minamino K, Yamaguchi K, Shultz LD, Iwasaki M, Tomita M, Suzuki Y, Nakano K, Koike Y, Yasumizu R, Sata M, Hirama N, Kubota I, Fukuhara S, Ikehara S. Treatment and transfer of emphysema by a new bone marrow transplantation method from normal mice to Tsk mice and vice versa. Stem Cells. 2006 Sep; 24(9):2071-7. PMID: 16709877.
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    177. Masaki H, Appel MC, Leahy L, Leif J, Paquin L, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice. Xenotransplantation. 2006 May; 13(3):224-32. PMID: 16756565.
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    178. Ishikawa F, Shimazu H, Shultz LD, Fukata M, Nakamura R, Lyons B, Shimoda K, Shimoda S, Kanemaru T, Nakamura K, Ito H, Kaji Y, Perry AC, Harada M. Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion. FASEB J. 2006 May; 20(7):950-2. PMID: 16585061.
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    179. Zhou J, Chen J, Zhong R, Mokotoff M, Shultz LD, Ball ED. Targeting gastrin-releasing peptide receptors on small cell lung cancer cells with a bispecific molecule that activates polyclonal T lymphocytes. Clin Cancer Res. 2006 Apr 1; 12(7 Pt 1):2224-31. PMID: 16609038.
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    180. Taube C, Miyahara N, Ott V, Swanson B, Takeda K, Loader J, Shultz LD, Tager AM, Luster AD, Dakhama A, Gelfand EW. The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness. J Immunol. 2006 Mar 1; 176(5):3157-64. PMID: 16493075.
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    181. Lyons BL, Smith RS, Hurd RE, Hawes NL, Burzenski LM, Nusinowitz S, Hasham MG, Chang B, Shultz LD. Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degeneration. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):1201-9. PMID: 16505059.
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    182. Thornley TB, Brehm MA, Markees TG, Shultz LD, Mordes JP, Welsh RM, Rossini AA, Greiner DL. TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. J Immunol. 2006 Feb 1; 176(3):1561-70. PMID: 16424185.
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    183. Mikaelian I, Hovick M, Silva KA, Burzenski LM, Shultz LD, Ackert-Bicknell CL, Cox GA, Sundberg JP. Expression of terminal differentiation proteins defines stages of mouse mammary gland development. Vet Pathol. 2006 Jan; 43(1):36-49. PMID: 16407485.
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    184. Macchiarini F, Manz MG, Palucka AK, Shultz LD. Humanized mice: are we there yet? J Exp Med. 2005 Nov 21; 202(10):1307-11. PMID: 16301740.
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    185. Park IK, Shultz LD, Letterio JJ, Gorham JD. TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J Immunol. 2005 Nov 1; 175(9):5666-74. PMID: 16237056.
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    186. Ueno M, Lyons BL, Burzenski LM, Gott B, Shaffer DJ, Roopenian DC, Shultz LD. Accelerated wound healing of alkali-burned corneas in MRL mice is associated with a reduced inflammatory signature. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4097-106. PMID: 16249486.
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    187. Helms C, Pelsue S, Cao L, Lamb E, Loffredo B, Taillon-Miller P, Herrin B, Burzenski LM, Gott B, Lyons BL, Keppler D, Shultz LD, Bowcock AM. The Tetratricopeptide repeat domain 7 gene is mutated in flaky skin mice: a model for psoriasis, autoimmunity, and anemia. Exp Biol Med (Maywood). 2005 Oct; 230(9):659-67. PMID: 16179734.
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    188. Yoshida S, Ishikawa F, Kawano N, Shimoda K, Nagafuchi S, Shimoda S, Yasukawa M, Kanemaru T, Ishibashi H, Shultz LD, Harada M. Human cord blood--derived cells generate insulin-producing cells in vivo. Stem Cells. 2005 Oct; 23(9):1409-16. PMID: 16210412.
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    189. Kawano N, Ishikawa F, Shimoda K, Yasukawa M, Nagafuji K, Miyamoto T, Baba E, Tanaka T, Yamasaki S, Gondo H, Otsuka T, Ohshima K, Shultz LD, Akashi K, Harada M. Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/beta2-microglobulin(null) mice. Leukemia. 2005 Aug; 19(8):1384-90. PMID: 15959532.
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    190. Minamiguchi H, Wingard JR, Laver JH, Mainali ES, Shultz LD, Ogawa M. An assay for human hematopoietic stem cells based on transplantation into nonobese diabetic recombination activating gene-null perforin-null mice. Biol Blood Marrow Transplant. 2005 Jul; 11(7):487-94. PMID: 15983548.
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    191. Ishikawa F, Yasukawa M, Lyons B, Yoshida S, Miyamoto T, Yoshimoto G, Watanabe T, Akashi K, Shultz LD, Harada M. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood. 2005 Sep 1; 106(5):1565-73. PMID: 15920010.
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    192. Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S, Kotb M, Gillies SD, King M, Mangada J, Greiner DL, Handgretinger R. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol. 2005 May 15; 174(10):6477-89. PMID: 15879151.
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    193. Jaeschke A, Rincón M, Doran B, Reilly J, Neuberg D, Greiner DL, Shultz LD, Rossini AA, Flavell RA, Davis RJ. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6931-5. PMID: 15867147.
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    194. Gordon EJ, Wicker LS, Peterson LB, Serreze DV, Markees TG, Shultz LD, Rossini AA, Greiner DL, Mordes JP. Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice. Diabetes. 2005 Jan; 54(1):107-15. PMID: 15616017.
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    195. Markees TG, Pearson T, Cuthbert A, Pearson AL, Shultz LD, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA. Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody. Transplantation. 2004 Dec 15; 78(11):1601-8. PMID: 15591948.
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    196. Huang Z, Coleman JM, Su Y, Mann M, Ryan J, Shultz LD, Huang H. SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner. Cytokine. 2005 Feb 7; 29(3):118-24. PMID: 15613279.
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    197. Ishikawa F, Yasukawa M, Yoshida S, Nakamura K, Nagatoshi Y, Kanemaru T, Shimoda K, Shimoda S, Miyamoto T, Okamura J, Shultz LD, Harada M. Human cord blood- and bone marrow-derived CD34+ cells regenerate gastrointestinal epithelial cells. FASEB J. 2004 Dec; 18(15):1958-60. PMID: 15467008.
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    198. Banuelos SJ, Markees TG, Phillips NE, Appel MC, Cuthbert A, Leif J, Mordes JP, Shultz LD, Rossini AA, Greiner DL. Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms. Transplantation. 2004 Sep 15; 78(5):660-7. PMID: 15371665.
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    199. Banuelos SJ, Shultz LD, Greiner DL, Burzenski LM, Gott B, Lyons BL, Rossini AA, Appel MC. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice. Clin Immunol. 2004 Sep; 112(3):273-83. PMID: 15308121.
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    200. Pearson T, Weiser P, Markees TG, Serreze DV, Wicker LS, Peterson LB, Cumisky AM, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3. Diabetes. 2004 Aug; 53(8):1972-8. PMID: 15277375.
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    201. Kuzin II, Ugine GD, Barth RK, Shultz LD, Nahm MH, Young FM, Bottaro A. A new murine model of humoral immuno-deficiency specifically affects class switching to T-independent antigens. Eur J Immunol. 2004 Jul; 34(7):1807-16. PMID: 15214029.
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    202. Appel MC, Banuelos SJ, Greiner DL, Shultz LD, Mordes JP, Rossini AA. Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody. Transplantation. 2004 May 15; 77(9):1341-9. PMID: 15167588.
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    203. Makatsori D, Kourmouli N, Polioudaki H, Shultz LD, McLean K, Theodoropoulos PA, Singh PB, Georgatos SD. The inner nuclear membrane protein lamin B receptor forms distinct microdomains and links epigenetically marked chromatin to the nuclear envelope. J Biol Chem. 2004 Jun 11; 279(24):25567-73. PMID: 15056654.
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    204. Hayashi S, Tsuneto M, Yamada T, Nose M, Yoshino M, Shultz LD, Yamazaki H. Lipopolysaccharide-induced osteoclastogenesis in Src homology 2-domain phosphatase-1-deficient viable motheaten mice. Endocrinology. 2004 Jun; 145(6):2721-9. PMID: 14988381.
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    205. Hayashi S, Yamada T, Tsuneto M, Yamane T, Takahashi M, Shultz LD, Yamazaki H. Distinct osteoclast precursors in the bone marrow and extramedullary organs characterized by responsiveness to Toll-like receptor ligands and TNF-alpha. J Immunol. 2003 Nov 15; 171(10):5130-9. PMID: 14607912.
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    206. Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms? Ann N Y Acad Sci. 2003 Nov; 1005:148-56. PMID: 14679049.
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    207. Shultz LD, Banuelos S, Lyons B, Samuels R, Burzenski L, Gott B, Lang P, Leif J, Appel M, Rossini A, Greiner DL. NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment. Transplantation. 2003 Oct 15; 76(7):1036-42. PMID: 14557749.
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    208. Zhou J, Chen J, Mokotoff M, Zhong R, Shultz LD, Ball ED. Bombesin/gastrin-releasing peptide receptor: a potential target for antibody-mediated therapy of small cell lung cancer. Clin Cancer Res. 2003 Oct 15; 9(13):4953-60. PMID: 14581370.
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    209. Turgeon NA, Banuelos SJ, Shultz LD, Lyons BL, Iwakoshi N, Greiner DL, Mordes JP, Rossini AA, Appel MC. Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice. Exp Biol Med (Maywood). 2003 Oct; 228(9):1096-104. PMID: 14530522.
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    210. Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice. Rev Endocr Metab Disord. 2003 Sep; 4(3):255-61. PMID: 14501176.
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    211. Pearson T, Markees TG, Serreze DV, Pierce MA, Marron MP, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol. 2003 Jul 1; 171(1):185-95. PMID: 12816997.
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    212. Kikuchi K, Lian ZX, He XS, Ansari AA, Ishibashi M, Miyakawa H, Shultz LD, Ikehara S, Gershwin ME. Appearance of human plasma cells following differentiation of human B cells in NOD/SCID mouse spleen. Clin Dev Immunol. 2003 Jun-Dec; 10(2-4):197-202. PMID: 14768952.
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    213. Spencer L, Shultz L, Rajan TV. T cells are required for host protection against Brugia malayi but need not produce or respond to interleukin-4. Infect Immun. 2003 Jun; 71(6):3097-106. PMID: 12761087.
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    214. Shultz LD, Banuelos SJ, Leif J, Appel MC, Cunningham M, Ballen K, Burzenski L, Greiner DL. Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells. Exp Hematol. 2003 Jun; 31(6):551-8. PMID: 12829032.
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    215. Lyons BL, Lynes MA, Burzenski L, Joliat MJ, Hadjout N, Shultz LD. Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient "viable motheaten" mice. Exp Hematol. 2003 Mar; 31(3):234-43. PMID: 12644021.
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    216. Paciorkowski N, Shultz LD, Rajan TV. Primed peritoneal B lymphocytes are sufficient to transfer protection against Brugia pahangi infection in mice. Infect Immun. 2003 Mar; 71(3):1370-8. PMID: 12595454.
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    217. Shultz LD, Lyons BL, Burzenski LM, Gott B, Samuels R, Schweitzer PA, Dreger C, Herrmann H, Kalscheuer V, Olins AL, Olins DE, Sperling K, Hoffmann K. Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Huët anomaly. Hum Mol Genet. 2003 Jan 1; 12(1):61-9. PMID: 12490533.
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    218. Johnson KR, Lane PW, Cook SA, Harris BS, Ward-Bailey PF, Bronson RT, Lyons BL, Shultz LD, Davisson MT. Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5. Genomics. 2003 Jan; 81(1):6-14. PMID: 12573256.
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    219. Capillo M, Mancuso P, Gobbi A, Monestiroli S, Pruneri G, Dell'Agnola C, Martinelli G, Shultz L, Bertolini F. Continuous infusion of endostatin inhibits differentiation, mobilization, and clonogenic potential of endothelial cell progenitors. Clin Cancer Res. 2003 Jan; 9(1):377-82. PMID: 12538491.
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    220. Dell'Agnola C, Rabascio C, Mancuso P, Capillo M, Pruneri G, Gobbi A, Minucci S, Ronzoni S, Volorio S, Calabrese L, Tradati N, Martinelli G, Shultz L, Bertolini F. In vitro and in vivo hematopoietic potential of human stem cells residing in muscle tissue. Exp Hematol. 2002 Aug; 30(8):905-14. PMID: 12160842.
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    221. Hoffmann K, Dreger CK, Olins AL, Olins DE, Shultz LD, Lucke B, Karl H, Kaps R, Müller D, Vayá A, Aznar J, Ware RE, Sotelo Cruz N, Lindner TH, Herrmann H, Reis A, Sperling K. Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly). Nat Genet. 2002 Aug; 31(4):410-4. PMID: 12118250.
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    222. Joliat MJ, Umeda S, Lyons BL, Lynes MA, Shultz LD. Establishment and characterization of a new osteogenic cell line (MOS-J) from a spontaneous C57BL/6J mouse osteosarcoma. In Vivo. 2002 Jul-Aug; 16(4):223-8. PMID: 12224130.
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    223. Rajan TV, Ganley L, Paciorkowski N, Spencer L, Klei TR, Shultz LD. Brugian infections in the peritoneal cavities of laboratory mice: kinetics of infection and cellular responses. Exp Parasitol. 2002 Apr; 100(4):235-47. PMID: 12128050.
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    224. Christianson SW, Greiner DL, Deluca D, Leif J, Phillips NE, Hayes SM, Hayashi S, Joliat MJ, Lyons BL, Shultz LD. T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7. J Autoimmun. 2002 Mar; 18(2):119-30. PMID: 11908944.
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    225. Joliat MJ, Lang PA, Lyons BL, Burzenski L, Lynes MA, Yi T, Sundberg JP, Shultz LD. Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice. J Autoimmun. 2002 Mar; 18(2):105-17. PMID: 11908943.
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    226. Lian ZX, Kita H, Okada T, Hsu T, Shultz LD, Dorshkind K, Ansari AA, Ikehara S, Naiki M, Gershwin ME. Increased frequency of pre-pro B cells in the bone marrow of New Zealand Black (NZB) mice: implications for a developmental block in B cell differentiation. Dev Immunol. 2002 Mar; 9(1):35-45. PMID: 12353661.
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    227. Khanna KV, Whaley KJ, Zeitlin L, Moench TR, Mehrazar K, Cone RA, Liao Z, Hildreth JE, Hoen TE, Shultz L, Markham RB. Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent. J Clin Invest. 2002 Jan; 109(2):205-11. PMID: 11805132.
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    228. Lian ZX, Okada T, Kita H, Hsu T, Shultz LD, Dorshkind K, Ansari AA, Naiki M, Ikehara S, Gershwin ME. Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice. Stem Cells. 2002; 20(4):293-300. PMID: 12110698.
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    229. Spencer L, Shultz L, Rajan TV. Interleukin-4 receptor-Stat6 signaling in murine infections with a tissue-dwelling nematode parasite. Infect Immun. 2001 Dec; 69(12):7743-52. PMID: 11705956.
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    230. Joliat MJ, Shultz LD. The molecular bases of spontaneous immunological mutations in the mouse and their homologous human diseases. Clin Immunol. 2001 Nov; 101(2):113-29. PMID: 11683570.
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    231. Nystuen A, Legare ME, Shultz LD, Frankel WN. A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice. Neuron. 2001 Oct 25; 32(2):203-12. PMID: 11683991.
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    232. Duez C, Tomkinson A, Shultz LD, Bratton DL, Gelfand EW. Fas deficiency delays the resolution of airway hyperresponsiveness after allergen sensitization and challenge. J Allergy Clin Immunol. 2001 Oct; 108(4):547-56. PMID: 11590380.
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    233. Rossi MI, Medina KL, Garrett K, Kolar G, Comp PC, Shultz LD, Capra JD, Wilson P, Schipul A, Kincade PW. Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice. J Immunol. 2001 Sep 15; 167(6):3033-42. PMID: 11544286.
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    234. Ballen KK, Valinski H, Greiner D, Shultz LD, Becker PS, Hsieh CC, Stewart FM, Quesenberry PJ. Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay. Br J Haematol. 2001 Jul; 114(1):211-8. PMID: 11472370.
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    235. Taguchi N, Ansari A, Hsu T, Hashimoto Y, Dorshkind K, Shultz L, Naiki M, Gershwin ME. Increased expression of mXBP-1 (TREB-5) in thymic B cells in New Zealand mice. J Autoimmun. 2001 Jun; 16(4):401-10. PMID: 11437488.
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    236. Taguchi N, Hashimoto Y, Hsu T, Ansari AA, Shultz L, Dorshkind K, Ikehara S, Naiki M, Gershwin ME. B cells are selectively associated with thymic cortical but not medullary pathology in NZB mice. J Autoimmun. 2001 Jun; 16(4):393-400. PMID: 11437487.
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    237. Nguyen VT, Ndoye A, Bassler KD, Shultz LD, Shields MC, Ruben BS, Webber RJ, Pittelkow MR, Lynch PJ, Grando SA. Classification, clinical manifestations, and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome: a reappraisal of paraneoplastic pemphigus. Arch Dermatol. 2001 Feb; 137(2):193-206. PMID: 11176692.
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    238. Gordon EJ, Woda BA, Shultz LD, Rossini AA, Greiner DL, Mordes JP. Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells. Transplantation. 2001 Jan 27; 71(2):319-27. PMID: 11213080.
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    239. Hsu HC, Shultz LD, Su X, Shi J, Yang PA, Relyea MJ, Zhang HG, Mountz JD. Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice. J Immunol. 2001 Jan 15; 166(2):772-80. PMID: 11145649.
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    240. Glimm H, Eisterer W, Lee K, Cashman J, Holyoake TL, Nicolini F, Shultz LD, von Kalle C, Eaves CJ. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. J Clin Invest. 2001 Jan; 107(2):199-206. PMID: 11160136.
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    241. Jiang S, Naito M, Kaizu C, Kuwata K, Hasegawa G, Mukaida N, Shultz LD. Lipopolysaccharide-induced cytokine and receptor expression and neutrophil infiltration in the liver of osteopetrosis (op/op) mutant mice. Liver. 2000 Dec; 20(6):465-74. PMID: 11169061.
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    242. Nguyen VT, Ndoye A, Shultz LD, Pittelkow MR, Grando SA. Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions. J Clin Invest. 2000 Dec; 106(12):1467-79. PMID: 11120754.
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    243. Hamelmann E, Takeda K, Haczku A, Cieslewicz G, Shultz L, Hamid Q, Xing Z, Gauldie J, Gelfand EW. Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice. Am J Respir Cell Mol Biol. 2000 Sep; 23(3):327-34. PMID: 10970823.
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    244. Schwarze J, Cieslewicz G, Joetham A, Ikemura T, Mäkelä MJ, Dakhama A, Shultz LD, Lamers MC, Gelfand EW. Critical roles for interleukin-4 and interleukin-5 during respiratory syncytial virus infection in the development of airway hyperresponsiveness after airway sensitization. Am J Respir Crit Care Med. 2000 Aug; 162(2 Pt 1):380-6. PMID: 10934057.
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    245. Wagar EJ, Cromwell MA, Shultz LD, Woda BA, Sullivan JL, Hesselton RM, Greiner DL. Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice. J Immunol. 2000 Jul 1; 165(1):518-27. PMID: 10861091.
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    246. Kollet O, Moore JG, Aviram R, Ben-Hur H, Liu BL, Nagler A, Shultz L, Feldman M, Lapidot T. The plant lectin FRIL supports prolonged in vitro maintenance of quiescent human cord blood CD34(+)CD38(-/low)/SCID repopulating stem cells. Exp Hematol. 2000 Jun; 28(6):726-36. PMID: 10880759.
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    247. Sasaki A, Yokoo H, Naito M, Kaizu C, Shultz LD, Nakazato Y. Effects of macrophage-colony-stimulating factor deficiency on the maturation of microglia and brain macrophages and on their expression of scavenger receptor. Neuropathology. 2000 Jun; 20(2):134-42. PMID: 10935450.
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    248. Sundberg JP, Boggess D, Bascom C, Limberg BJ, Shultz LD, Sundberg BA, King LE, Montagutelli X. Lanceolate hair-J (lahJ): a mouse model for human hair disorders. Exp Dermatol. 2000 Jun; 9(3):206-18. PMID: 10839719.
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    249. Tagaya H, Kunisada T, Yamazaki H, Yamane T, Tokuhisa T, Wagner EF, Sudo T, Shultz LD, Hayashi SI. Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice. Blood. 2000 Jun 1; 95(11):3363-70. PMID: 10828017.
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    250. Kollet O, Peled A, Byk T, Ben-Hur H, Greiner D, Shultz L, Lapidot T. beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function. Blood. 2000 May 15; 95(10):3102-5. PMID: 10807775.
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    251. Babu S, Ganley LM, Klei TR, Shultz LD, Rajan TV. Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi. Infect Immun. 2000 May; 68(5):3034-5. PMID: 10769010.
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    252. Shimada-Hiratsuka M, Naito M, Kaizu C, Shuying J, Hasegawa G, Shultz LD. Defective macrophage recruitment and clearance of apoptotic cells in the uterus of osteopetrotic mutant mice lacking macrophage colony-stimulating factor (M-CSF). J Submicrosc Cytol Pathol. 2000 Apr; 32(2):297-307. PMID: 11085218.
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    253. Shultz LD, Lang PA, Christianson SW, Gott B, Lyons B, Umeda S, Leiter E, Hesselton R, Wagar EJ, Leif JH, Kollet O, Lapidot T, Greiner DL. NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells. J Immunol. 2000 Mar 1; 164(5):2496-507. PMID: 10679087.
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    254. Ballen K, Becker PS, Greiner D, Valinski H, Shearin D, Berrios V, Dooner G, Hsieh CC, Wuu J, Shultz L, Cerny J, Leif J, Stewart FM, Quesenberry P. Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice. Br J Haematol. 2000 Mar; 108(3):629-40. PMID: 10759723.
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    255. Paciorkowski N, Porte P, Shultz LD, Rajan TV. B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites. J Exp Med. 2000 Feb 21; 191(4):731-6. PMID: 10684864.
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    256. Hashimoto Y, Dorshkind K, Montecino-Rodriguez E, Taguchi N, Shultz L, Gershwin ME. NZB mice exhibit a primary T cell defect in fetal thymic organ culture. J Immunol. 2000 Feb 1; 164(3):1569-75. PMID: 10640776.
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    257. Taguchi N, Hashimoto Y, Naiki M, Farr AG, Boyd RL, Ansari AA, Shultz LD, Kotzin BL, Dorshkind K, Ikehara S, Gershwin ME. Abnormal thymic expression of epithelial cell adhesion molecule (EP-CAM) in New Zealand Black (NZB) mice. J Autoimmun. 1999 Dec; 13(4):393-404. PMID: 10585755.
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    258. Takeoka Y, Taguchi N, Shultz L, Boyd RL, Naiki M, Ansari AA, Gershwin ME. Apoptosis and the thymic microenvironment in murine lupus. J Autoimmun. 1999 Nov; 13(3):325-34. PMID: 10550220.
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    259. Saito H, Shultz LD, Sinha M, Papaconstantinou J. Induction of the alpha(1)-antichymotrypsin gene in the brain associated with TGF-beta1 deficiency or systemic administration of endotoxin. Biochem Biophys Res Commun. 1999 Sep 24; 263(2):270-5. PMID: 10491283.
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    260. Babu S, Shultz LD, Rajan TV. T cells facilitate Brugia malayi development in TCRalpha(null) mice. Exp Parasitol. 1999 Sep; 93(1):55-7. PMID: 10464039.
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    261. Kollet O, Aviram R, Chebath J, ben-Hur H, Nagler A, Shultz L, Revel M, Lapidot T. The soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro maintenance and proliferation of human CD34(+)CD38(-/low) cells capable of repopulating severe combined immunodeficiency mice. Blood. 1999 Aug 1; 94(3):923-31. PMID: 10419883.
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    262. Umeda S, Beamer WG, Takagi K, Naito M, Hayashi S, Yonemitsu H, Yi T, Shultz LD. Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density. Am J Pathol. 1999 Jul; 155(1):223-33. PMID: 10393854.
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    263. Babu S, Shultz LD, Klei TR, Rajan TV. Immunity in experimental murine filariasis: roles of T and B cells revisited. Infect Immun. 1999 Jun; 67(6):3166-7. PMID: 10338538.
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    264. Markees TG, Serreze DV, Phillips NE, Sorli CH, Gordon EJ, Shultz LD, Noelle RJ, Woda BA, Greiner DL, Mordes JP, Rossini AA. NOD mice have a generalized defect in their response to transplantation tolerance induction. Diabetes. 1999 May; 48(5):967-74. PMID: 10331399.
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    265. Schwarze J, Cieslewicz G, Hamelmann E, Joetham A, Shultz LD, Lamers MC, Gelfand EW. IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection. J Immunol. 1999 Mar 1; 162(5):2997-3004. PMID: 10072551.
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    266. Ito S, Naito M, Kobayashi Y, Takatsuka H, Jiang S, Usuda H, Umezu H, Hasegawa G, Arakawa M, Shultz LD, Elomaa O, Tryggvason K. Roles of a macrophage receptor with collagenous structure (MARCO) in host defense and heterogeneity of splenic marginal zone macrophages. Arch Histol Cytol. 1999 Mar; 62(1):83-95. PMID: 10223745.
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    267. Takeoka Y, Taguchi N, Kotzin BL, Bennett S, Vyse TJ, Boyd RL, Naiki M, Konishi J, Ansari AA, Shultz LD, Gershwin ME. Thymic microenvironment and NZB mice: the abnormal thymic microenvironment of New Zealand mice correlates with immunopathology. Clin Immunol. 1999 Mar; 90(3):388-98. PMID: 10075868.
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    268. Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T, Nagler A, Ben-Hur H, Many A, Shultz L, Lider O, Alon R, Zipori D, Lapidot T. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science. 1999 Feb 5; 283(5403):845-8. PMID: 9933168.
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    269. Myint YY, Miyakawa K, Naito M, Shultz LD, Oike Y, Yamamura K, Takahashi K. Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation. Am J Pathol. 1999 Feb; 154(2):553-66. PMID: 10027413.
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    270. Evans R, Shultz LD, Dranoff G, Fuller JA, Kamdar SJ. CSF-1 regulation of Il6 gene expression by murine macrophages: a pivotal role for GM-CSF. J Leukoc Biol. 1998 Dec; 64(6):810-6. PMID: 9850165.
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    271. Brown BA, Li Y, Brown JC, Hardin CC, Roberts JF, Pelsue SC, Shultz LD. Isolation and characterization of a monoclonal anti-quadruplex DNA antibody from autoimmune "viable motheaten" mice. Biochemistry. 1998 Nov 17; 37(46):16325-37. PMID: 9819225.
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    272. Yang W, Mckenna SD, Jiao H, Tabrizi M, Lynes MA, Shultz LD, Yi T. SHP-1 deficiency in B-lineage cells is associated with heightened lyn protein expression and increased lyn kinase activity. Exp Hematol. 1998 Nov; 26(12):1126-32. PMID: 9808051.
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    273. Miyamoto A, Kunisada T, Yamazaki H, Miyake K, Nishikawa SI, Sudo T, Shultz LD, Hayashi SI. Establishment and characterization of pro-B cell lines from motheaten mutant mouse defective in SHP-1 protein tyrosine phosphatase. Immunol Lett. 1998 Sep; 63(2):75-82. PMID: 9761368.
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    274. Babu S, Porte P, Klei TR, Shultz LD, Rajan TV. Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice. J Immunol. 1998 Aug 1; 161(3):1428-32. PMID: 9686607.
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    275. Kunisada T, Yoshida H, Yamazaki H, Miyamoto A, Hemmi H, Nishimura E, Shultz LD, Nishikawa S, Hayashi S. Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors. Development. 1998 Aug; 125(15):2915-23. PMID: 9655813.
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    276. Gordon EJ, Markees TG, Phillips NE, Noelle RJ, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody. Diabetes. 1998 Aug; 47(8):1199-206. PMID: 9703317.
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    277. Vu TN, Lee TX, Ndoye A, Shultz LD, Pittelkow MR, Dahl MV, Lynch PJ, Grando SA. The pathophysiological significance of nondesmoglein targets of pemphigus autoimmunity. Development of antibodies against keratinocyte cholinergic receptors in patients with pemphigus vulgaris and pemphigus foliaceus. Arch Dermatol. 1998 Aug; 134(8):971-80. PMID: 9722727.
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    278. Markees TG, Phillips NE, Gordon EJ, Noelle RJ, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4. J Clin Invest. 1998 Jun 1; 101(11):2446-55. PMID: 9616216.
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    279. Ramírez M, Rottman GA, Shultz LD, Civin CI. Mature human hematopoietic cells in donor bone marrow complicate interpretation of stem/progenitor cell assays in xenogeneic hematopoietic chimeras. Exp Hematol. 1998 Apr; 26(4):332-44. PMID: 9546317.
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    280. Pelsue SC, Schweitzer PA, Schweitzer IB, Christianson SW, Gott B, Sundberg JP, Beamer WG, Shultz LD. Lymphadenopathy, elevated serum IgE levels, autoimmunity, and mast cell accumulation in flaky skin mutant mice. Eur J Immunol. 1998 Apr; 28(4):1379-88. PMID: 9565378.
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    281. Herbst LH, Sundberg JP, Shultz LD, Gray BA, Klein PA. Tumorigenicity of green turtle fibropapilloma-derived fibroblast lines in immunodeficient mice. Lab Anim Sci. 1998 Apr; 48(2):162-7. PMID: 10090007.
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    282. Takatsuka H, Umezu H, Hasegawa G, Usuda H, Ebe Y, Naito M, Shultz LD. Bone remodeling and macrophage differentiation in osteopetrosis (op) mutant mice defective in the production of macrophage colony-stimulating factor. J Submicrosc Cytol Pathol. 1998 Apr; 30(2):239-47. PMID: 9648288.
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    283. Rajan TV, Shultz LD, Babu S, Doukas J, Greiner D, Porte P. Diethylcarbamazine (DEC) does not induce nitric oxide (NO) synthesis. Exp Parasitol. 1998 Mar; 88(3):217-22. PMID: 9562425.
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    284. Yamada G, Nakamura S, Haraguchi R, Sakai M, Suzuki K, Miyado K, Hasuwa H, Ogino Y, Minami T, Tohno Y, Blum M, Shultz LD. Aberrant regulation of bone trace elements in motheaten and osteopetrosis mutant mice. Cell Mol Biol (Noisy-le-grand). 1998 Mar; 44(2):315-9. PMID: 9593582.
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    285. Takahashi K, Miyakawa K, Wynn AA, Nakayama K, Myint YY, Naito M, Shultz LD, Tominaga A, Takatsu K. Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. Am J Pathol. 1998 Feb; 152(2):445-56. PMID: 9466571.
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    286. Kapasi ZF, Qin D, Kerr WG, Kosco-Vilbois MH, Shultz LD, Tew JG, Szakal AK. Follicular dendritic cell (FDC) precursors in primary lymphoid tissues. J Immunol. 1998 Feb 1; 160(3):1078-84. PMID: 9570519.
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    287. Greiner DL, Hesselton RA, Shultz LD. SCID mouse models of human stem cell engraftment. Stem Cells. 1998; 16(3):166-77. PMID: 9617892.
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    288. Foy TM, McIlraith M, Masters SR, Dunn JJ, Rossini AA, Shultz LD, Hesselton RA, Wagar EJ, Lipsky PE, Noelle RJ, Greiner DL. Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice. Cell Transplant. 1998 Jan-Feb; 7(1):25-35. PMID: 9489760.
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    289. Martin A, Matsuoka N, Zhang J, Zhou A, Nakashima M, Unger P, Schwartz AE, Friedman EW, Shultz LD, Davies TF. Preservation of functioning human thyroid "organoids" in the scid mouse. IV. In vivo selection of an intrathyroidal T cell receptor repertoire. Endocrinology. 1997 Nov; 138(11):4868-75. PMID: 9348217.
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    290. Thrall RS, Vogel SN, Evans R, Shultz LD. Role of tumor necrosis factor-alpha in the spontaneous development of pulmonary fibrosis in viable motheaten mutant mice. Am J Pathol. 1997 Nov; 151(5):1303-10. PMID: 9358756.
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    291. Noben-Trauth N, Shultz LD, Brombacher F, Urban JF, Gu H, Paul WE. An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10838-43. PMID: 9380721.
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    292. Westhoff CM, Whittier A, Kathol S, McHugh J, Zajicek C, Shultz LD, Wylie DE. DNA-binding antibodies from viable motheaten mutant mice: implications for B cell tolerance. J Immunol. 1997 Sep 15; 159(6):3024-33. PMID: 9300728.
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    293. Allay JA, Dennis JE, Haynesworth SE, Majumdar MK, Clapp DW, Shultz LD, Caplan AI, Gerson SL. LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors. Hum Gene Ther. 1997 Aug 10; 8(12):1417-27. PMID: 9287142.
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    294. Takeda K, Hamelmann E, Joetham A, Shultz LD, Larsen GL, Irvin CG, Gelfand EW. Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J Exp Med. 1997 Aug 4; 186(3):449-54. PMID: 9236197.
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    295. Shultz LD, Rajan TV, Greiner DL. Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency. Trends Biotechnol. 1997 Aug; 15(8):302-7. PMID: 9263478.
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    296. Nakayama K, Takahashi K, Shultz LD, Miyakawa K, Tomita K. Abnormal development and differentiation of macrophages and dendritic cells in viable motheaten mutant mice deficient in haematopoietic cell phosphatase. Int J Exp Pathol. 1997 Aug; 78(4):245-57. PMID: 9505936.
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    297. Markees TG, Phillips NE, Noelle RJ, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand. Transplantation. 1997 Jul 27; 64(2):329-35. PMID: 9256196.
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    298. Hogan CJ, Shpall EJ, McNulty O, McNiece I, Dick JE, Shultz LD, Keller G. Engraftment and development of human CD34(+)-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice. Blood. 1997 Jul 1; 90(1):85-96. PMID: 9207442.
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    299. Jiao H, Yang W, Berrada K, Tabrizi M, Shultz L, Yi T. Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction. Exp Hematol. 1997 Jul; 25(7):592-600. PMID: 9216734.
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    300. Cashman JD, Lapidot T, Wang JC, Doedens M, Shultz LD, Lansdorp P, Dick JE, Eaves CJ. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood. 1997 Jun 15; 89(12):4307-16. PMID: 9192753.
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    301. Koch PJ, Mahoney MG, Ishikawa H, Pulkkinen L, Uitto J, Shultz L, Murphy GF, Whitaker-Menezes D, Stanley JR. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol. 1997 Jun 2; 137(5):1091-102. PMID: 9166409.
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    302. Serreze DV, Chapman HD, Varnum DS, Gerling I, Leiter EH, Shultz LD. Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent. J Immunol. 1997 Apr 15; 158(8):3978-86. PMID: 9103469.
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    303. Christianson SW, Greiner DL, Hesselton RA, Leif JH, Wagar EJ, Schweitzer IB, Rajan TV, Gott B, Roopenian DC, Shultz LD. Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice. J Immunol. 1997 Apr 15; 158(8):3578-86. PMID: 9103418.
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    304. Zhu H, Naito M, Umezu H, Moriyama H, Takatsuka H, Takahashi K, Shultz LD. Macrophage differentiation and expression of macrophage colony-stimulating factor in murine milky spots and omentum after macrophage elimination. J Leukoc Biol. 1997 Apr; 61(4):436-44. PMID: 9103230.
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    305. Nakamura MC, Niemi EC, Fisher MJ, Shultz LD, Seaman WE, Ryan JC. Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J Exp Med. 1997 Feb 17; 185(4):673-84. PMID: 9034146.
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    306. Tapley P, Shevde NK, Schweitzer PA, Gallina M, Christianson SW, Lin IL, Stein RB, Shultz LD, Rosen J, Lamb P. Increased G-CSF responsiveness of bone marrow cells from hematopoietic cell phosphatase deficient viable motheaten mice. Exp Hematol. 1997 Feb; 25(2):122-31. PMID: 9015212.
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    307. Naito M, Umeda S, Takahashi K, Shultz LD. Macrophage differentiation and granulomatous inflammation in osteopetrotic mice (op/op) defective in the production of CSF-1. Mol Reprod Dev. 1997 Jan; 46(1):85-91. PMID: 8981368.
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    308. Sundberg JP, France M, Boggess D, Sundberg BA, Jenson AB, Beamer WG, Shultz LD. Development and progression of psoriasiform dermatitis and systemic lesions in the flaky skin (fsn) mouse mutant. Pathobiology. 1997; 65(5):271-86. PMID: 9459497.
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    309. Takeoka Y, Chen SY, Boyd RL, Tsuneyama K, Taguchi N, Morita S, Yago H, Suehiro S, Ansari AA, Shultz LD, Gershwin ME. A comparative analysis of the murine thymic microenvironment in normal, autoimmune, and immunodeficiency states. Dev Immunol. 1997; 5(2):79-89. PMID: 9587708.
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    310. Rajan TV, Moore JM, Shultz LD. Immunodeficient mice as hosts for hemoparasitic infections. Parasitol Today. 1996 Dec; 12(12):479-85. PMID: 15275267.
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    311. Pflumio F, Izac B, Katz A, Shultz LD, Vainchenker W, Coulombel L. Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells. Blood. 1996 Nov 15; 88(10):3731-40. PMID: 8916937.
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    312. Serreze DV, Chapman HD, Varnum DS, Hanson MS, Reifsnyder PC, Richard SD, Fleming SA, Leiter EH, Shultz LD. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice. J Exp Med. 1996 Nov 1; 184(5):2049-53. PMID: 8920894.
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    313. Yoshida H, Hayashi S, Shultz LD, Yamamura K, Nishikawa S, Nishikawa S, Kunisada T. Neural and skin cell-specific expression pattern conferred by steel factor regulatory sequence in transgenic mice. Dev Dyn. 1996 Oct; 207(2):222-32. PMID: 8906425.
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    314. Takeoka Y, Chen SY, Yago H, Boyd R, Suehiro S, Shultz LD, Ansari AA, Gershwin ME. The murine thymic microenvironment: changes with age. Int Arch Allergy Immunol. 1996 Sep; 111(1):5-12. PMID: 8753837.
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    315. Christianson SW, Greiner DL, Schweitzer IB, Gott B, Beamer GL, Schweitzer PA, Hesselton RM, Shultz LD. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell Immunol. 1996 Aug 1; 171(2):186-99. PMID: 8806787.
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    316. Umeda S, Takahashi K, Shultz LD, Naito M, Takagi K. Effects of macrophage colony-stimulating factor on macrophages and their related cell populations in the osteopetrosis mouse defective in production of functional macrophage colony-stimulating factor protein. Am J Pathol. 1996 Aug; 149(2):559-74. PMID: 8701995.
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    317. Rajan TV, Porte P, Yates JA, Keefer L, Shultz LD. Role of nitric oxide in host defense against an extracellular, metazoan parasite, Brugia malayi. Infect Immun. 1996 Aug; 64(8):3351-3. PMID: 8757874.
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    318. Heine D, Passmore HC, Patel V, Shultz LD, Ward-Bailey P, Cook SA, Davisson MT. Effect of the mouse scid mutation on meiotic recombination. Mamm Genome. 1996 Jul; 7(7):497-500. PMID: 8672126.
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    319. Zhong RK, Donnenberg AD, Shultz LD, Swerdlow SH, Lee E, Rubin J, Kozii R, Chen J, Griffin DL, Wilson J, Ball ED. Evaluation of monoclonal antibody-mediated anti-acute myeloid leukemia immunotherapy in a SCID/hu model. Leuk Res. 1996 Jul; 20(7):581-9. PMID: 8795692.
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    320. Noben-Trauth N, Schweitzer PA, Johnson KR, Wolf SF, Knowles BB, Shultz LD. The interleukin-12 beta subunit (p40) maps to mouse chromosome 11. Mamm Genome. 1996 May; 7(5):392. PMID: 8661733.
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    321. Rajan TV, Greiner DL, Yates JA, Shultz LD. Growth of the human filarial parasite Brugia malayi in mice lacking major histocompatibility complex class II antigen expression. Acta Trop. 1996 May; 61(3):267-71. PMID: 8790777.
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    322. Schweitzer PA, Noben-Trauth N, Pelsue SC, Johnson KR, Wolf SF, Shultz LD. Genetic mapping of the IL-12 alpha chain gene (Il12a) on mouse chromosome 3. Mamm Genome. 1996 May; 7(5):394-5. PMID: 8661735.
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    323. Phillips JA, Romball CG, Hobbs MV, Ernst DN, Shultz L, Weigle WO. CD4+ T cell activation and tolerance induction in B cell knockout mice. J Exp Med. 1996 Apr 1; 183(4):1339-44. PMID: 8666892.
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    324. Araki M, Fukumatsu Y, Katabuchi H, Shultz LD, Takahashi K, Okamura H. Follicular development and ovulation in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation. Biol Reprod. 1996 Feb; 54(2):478-84. PMID: 8788202.
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    325. Lowry PA, Shultz LD, Greiner DL, Hesselton RM, Kittler EL, Tiarks CY, Rao SS, Reilly J, Leif JH, Ramshaw H, Stewart FM, Quesenberry PJ. Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients. Biol Blood Marrow Transplant. 1996 Feb; 2(1):15-23. PMID: 9078350.
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    326. Naito M, Umeda S, Yamamoto T, Moriyama H, Umezu H, Hasegawa G, Usuda H, Shultz LD, Takahashi K. Development, differentiation, and phenotypic heterogeneity of murine tissue macrophages. J Leukoc Biol. 1996 Feb; 59(2):133-8. PMID: 8603984.
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    327. Umeda S, Takahashi K, Naito M, Shultz LD, Takagi K. Neonatal changes of osteoclasts in osteopetrosis (op/op) mice defective in production of functional macrophage colony-stimulating factor (M-CSF) protein and effects of M-CSF on osteoclast development and differentiation. J Submicrosc Cytol Pathol. 1996 Jan; 28(1):13-26. PMID: 8929623.
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    328. Greiner DL, Shultz LD, Deluca D, Leif JH, Christianson SW, Hesselton RM. HIV-1 infectivity of human T cells in a human/murine chimeric fetal thymic organ culture system. In Vivo. 1996 Jan-Feb; 10(1):33-7. PMID: 8726809.
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    329. Blazar BR, Brennan CA, Broxmeyer HE, Shultz LD, Vallera DA. Transgenic mice expressing either bovine growth hormone (bGH) or human GH releasing hormone (hGRH) have increased splenic progenitor cell colony formation and DNA synthesis in vitro and in vivo. Exp Hematol. 1995 Dec; 23(13):1397-406. PMID: 7498369.
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    330. Serreze DV, Leiter EH, Hanson MS, Christianson SW, Shultz LD, Hesselton RM, Greiner DL. Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells. Diabetes. 1995 Dec; 44(12):1392-8. PMID: 7589844.
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    331. Beamer WG, Pelsue SC, Shultz LD, Sundberg JP, Barker JE. The flaky skin (fsn) mutation in mice: map location and description of the anemia. Blood. 1995 Oct 15; 86(8):3220-6. PMID: 7579418.
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    332. Pelsue SC, Schweitzer PA, Beamer WG, Shultz LD. Mapping of the flaky skin (fsn) mutation on distal mouse chromosome 17. Mamm Genome. 1995 Oct; 6(10):758. PMID: 8563181.
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    333. Hesselton RM, Greiner DL, Mordes JP, Rajan TV, Sullivan JL, Shultz LD. High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice. J Infect Dis. 1995 Oct; 172(4):974-82. PMID: 7561218.
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    334. Takeoka Y, Whitmer KJ, Chen SY, Ansari AA, Boyd RL, Shultz LD, Suehiro S, Gershwin ME. Thymic epithelial cell abnormalities in (NZB x H-2u)F1 mice. Clin Immunol Immunopathol. 1995 Sep; 76(3 Pt 1):297-307. PMID: 7554452.
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    335. Buhlmann JE, Foy TM, Aruffo A, Crassi KM, Ledbetter JA, Green WR, Xu JC, Shultz LD, Roopesian D, Flavell RA, et al. In the absence of a CD40 signal, B cells are tolerogenic. Immunity. 1995 Jun; 2(6):645-53. PMID: 7540943.
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    336. Rajan TV, Shultz LD, Yates J, Greiner DL. B lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi. J Parasitol. 1995 Jun; 81(3):490-3. PMID: 7776141.
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    337. Moore JM, Kumar N, Shultz LD, Rajan TV. Maintenance of the human malarial parasite, Plasmodium falciparum, in scid mice and transmission of gametocytes to mosquitoes. J Exp Med. 1995 Jun 1; 181(6):2265-70. PMID: 7760012.
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    338. Rohane PW, Shimada A, Kim DT, Edwards CT, Charlton B, Shultz LD, Fathman CG. Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice. Diabetes. 1995 May; 44(5):550-4. PMID: 7729614.
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    339. Greiner DL, Shultz LD, Yates J, Appel MC, Perdrizet G, Hesselton RM, Schweitzer I, Beamer WG, Shultz KL, Pelsue SC, et al. Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice. Am J Pathol. 1995 Apr; 146(4):888-902. PMID: 7717456.
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    340. Larochelle A, Vormoor J, Lapidot T, Sher G, Furukawa T, Li Q, Shultz LD, Olivieri NF, Stamatoyannopoulos G, Dick JE. Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols. Hum Mol Genet. 1995 Feb; 4(2):163-72. PMID: 7757063.
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    341. DeLuca D, Bluestone JA, Shultz LD, Sharrow SO, Tatsumi Y. Programmed differentiation of murine thymocytes during fetal thymus organ culture. J Immunol Methods. 1995 Jan 13; 178(1):13-29. PMID: 7829862.
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    342. Shultz LD, Schweitzer PA, Christianson SW, Gott B, Schweitzer IB, Tennent B, McKenna S, Mobraaten L, Rajan TV, Greiner DL, et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol. 1995 Jan 1; 154(1):180-91. PMID: 7995938.
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    343. Rajan TV, Bailis JM, Yates JA, Shultz LD, Greiner DL, Nelson FK. Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis. Acta Trop. 1994 Dec; 58(3-4):283-9. PMID: 7709867.
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    344. Welsh RM, O'Donnell CL, Shultz LD. Antiviral activity of NK 1.1+ natural killer cells in C57BL/6 scid mice infected with murine cytomegalovirus. Nat Immun. 1994 Sep-Oct; 13(5):239-45. PMID: 7833623.
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    345. Martin A, Valentine M, Unger P, Yeung SW, Shultz LD, Davies TF. Engraftment of human lymphocytes and thyroid tissue into scid and rag2-deficient mice: absent progression of lymphocytic infiltration. J Clin Endocrinol Metab. 1994 Sep; 79(3):716-23. PMID: 8077352.
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    346. Smithson G, Beamer WG, Shultz KL, Christianson SW, Shultz LD, Kincade PW. Increased B lymphopoiesis in genetically sex steroid-deficient hypogonadal (hpg) mice. J Exp Med. 1994 Aug 1; 180(2):717-20. PMID: 8046347.
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    347. Rajan TV, Nelson FK, Killeen N, Shultz LD, Yates JA, Bailis JM, Littman DR, Greiner DL. CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi. Exp Parasitol. 1994 Jun; 78(4):352-60. PMID: 7911434.
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    348. Takahashi K, Naito M, Umeda S, Shultz LD. The role of macrophage colony-stimulating factor in hepatic glucan-induced granuloma formation in the osteopetrosis mutant mouse defective in the production of macrophage colony-stimulating factor. Am J Pathol. 1994 Jun; 144(6):1381-92. PMID: 8203474.
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    349. Takahashi K, Umeda S, Shultz LD, Hayashi S, Nishikawa S. Effects of macrophage colony-stimulating factor (M-CSF) on the development, differentiation, and maturation of marginal metallophilic macrophages and marginal zone macrophages in the spleen of osteopetrosis (op) mutant mice lacking functional M-CSF activity. J Leukoc Biol. 1994 May; 55(5):581-8. PMID: 8182336.
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    350. Rajan TV, Nelson FK, Shultz LD, Shultz KL, Beamer WG, Yates J, Greiner DL. Influence of gonadal steroids on susceptibility to Brugia malayi in scid mice. Acta Trop. 1994 Apr; 56(4):307-14. PMID: 8023754.
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    351. Gerling IC, Friedman H, Greiner DL, Shultz LD, Leiter EH. Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Diabetes. 1994 Mar; 43(3):433-40. PMID: 8314017.
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    352. Valentine M, Martin A, Unger P, Katz N, Shultz LD, Davies TF. Preservation of functioning human thyroid "organoids" in the severe combined immunodeficient mouse. III. Thyrotropin independence of thyroid follicle formation. Endocrinology. 1994 Mar; 134(3):1225-30. PMID: 8119163.
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    353. Szomolanyi-Tsuda E, Dundon PL, Joris I, Shultz LD, Woda BA, Welsh RM. Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice. Am J Pathol. 1994 Feb; 144(2):359-71. PMID: 8311119.
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    354. Hayes SM, Shultz LD, Greiner DL. Localization of prothymocytes from wild-type and viable motheaten mice following intravenous injection into irradiated adoptive recipients. Cell Immunol. 1994 Feb; 153(2):344-55. PMID: 8118868.
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    355. Usuda H, Naito M, Umeda S, Takahashi K, Shultz LD. Ultrastructure of macrophages and dendritic cells in osteopetrosis (op) mutant mice lacking macrophage colony-stimulating factor (M-CSF/CSF-1) activity. J Submicrosc Cytol Pathol. 1994 Jan; 26(1):111-9. PMID: 8149328.
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    356. De Riu S, Martin A, Valentine M, Concepcion ES, Shultz LD, Davies TF. Graves' disease thyroid tissue transplants in scid mice: persistent selectivity in hTcR Va gene family use. Autoimmunity. 1994; 19(4):271-7. PMID: 7578854.
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    357. Kapasi ZF, Kosco-Vilbois MH, Shultz LD, Tew JG, Szakal AK. Cellular origin of follicular dendritic cells. Adv Exp Med Biol. 1994; 355:231-5. PMID: 7709828.
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    358. Koo GC, Rosen H, Sirotina A, Ma XD, Shultz LD. Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice. J Immunol. 1993 Dec 15; 151(12):6733-41. PMID: 8258688.
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    359. Yeoman H, Gress RE, Bare CV, Leary AG, Boyse EA, Bard J, Shultz LD, Harris DT, DeLuca D. Human bone marrow and umbilical cord blood cells generate CD4+ and CD8+ single-positive T cells in murine fetal thymus organ culture. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10778-82. PMID: 7902570.
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    360. Beamer WG, Shultz KL, Tennent BJ, Shultz LD. Granulosa cell tumorigenesis in genetically hypogonadal-immunodeficient mice grafted with ovaries from tumor-susceptible donors. Cancer Res. 1993 Aug 15; 53(16):3741-6. PMID: 8339285.
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    361. Martin A, Valentine M, Unger P, Lichtenstein C, Schwartz AE, Friedman EW, Shultz LD, Davies TF. Preservation of functioning human thyroid organoids in the scid mouse: 1. System characterization. J Clin Endocrinol Metab. 1993 Aug; 77(2):305-10. PMID: 8345031.
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    362. Matsuoka N, Martin A, Concepcion ES, Unger P, Shultz LD, Davies TF. Preservation of functioning human thyroid organoids in the scid mouse: II. Biased use of intrathyroidal T cell receptor V genes. J Clin Endocrinol Metab. 1993 Aug; 77(2):311-5. PMID: 8345032.
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    363. Shultz LD, Schweitzer PA, Rajan TV, Yi T, Ihle JN, Matthews RJ, Thomas ML, Beier DR. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell. 1993 Jul 2; 73(7):1445-54. PMID: 8324828.
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    364. Katoh S, Bendig MM, Kanai Y, Shultz LD, Hitoshi Y, Takatsu K, Tominaga A. Maintenance of CD5+ B cells at an early developmental stage by interleukin-5: evidence from immunoglobulin gene usage in interleukin-5 transgenic mice. DNA Cell Biol. 1993 Jul-Aug; 12(6):481-91. PMID: 7687132.
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    365. Sundberg JP, Boggess D, Sundberg BA, Beamer WG, Shultz LD. Epidermal dendritic cell populations in the flaky skin mutant mouse. Immunol Invest. 1993 Jul; 22(5):389-401. PMID: 8406628.
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    366. Kapasi ZF, Burton GF, Shultz LD, Tew JG, Szakal AK. Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. Influence of B and T cells. J Immunol. 1993 Apr 1; 150(7):2648-58. PMID: 8454847.
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    367. Kapasi ZF, Burton GF, Shultz LD, Tew JG, Szakal AK. Cellular requirements for functional reconstitution of follicular dendritic cells in SCID mice. Adv Exp Med Biol. 1993; 329:383-6. PMID: 8379399.
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    368. Christianson SW, Shultz LD, Leiter EH. Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes. 1993 Jan; 42(1):44-55. PMID: 8093606.
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    369. Takahashi K, Naito M, Shultz LD, Hayashi S, Nishikawa S. Differentiation of dendritic cell populations in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation. J Leukoc Biol. 1993 Jan; 53(1):19-28. PMID: 8426088.
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    370. Takahashi K, Naito M, Shultz LD. Differentiation of epidermal Langerhans cells in macrophage colony-stimulating-factor-deficient mice homozygous for the osteopetrosis (op) mutation. J Invest Dermatol. 1992 Nov; 99(5):46S-47S. PMID: 1431208.
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    371. Rajan TV, Nelson FK, Shultz LD, Koller BH, Greiner DL. CD8+ T lymphocytes are not required for murine resistance to human filarial parasites. J Parasitol. 1992 Aug; 78(4):744-6. PMID: 1386111.
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    372. Prochazka M, Gaskins HR, Shultz LD, Leiter EH. The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3290-4. PMID: 1373493.
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    373. Greiner DL, Rajan TV, Shultz LD. Animal models for immunodeficiency diseases. Immunol Today. 1992 Apr; 13(4):116-7. PMID: 1349811.
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    374. Disney JE, Barth AL, Shultz LD. Defective repair of radiation-induced chromosomal damage in scid/scid mice. Cytogenet Cell Genet. 1992; 59(1):39-44. PMID: 1733671.
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    375. Rajan TV, Shultz LD, Greiner DL. Lack of peripherally induced tolerance to established skin allografts in immunologically reconstituted scid mice. Dev Immunol. 1992; 3(1):45-50. PMID: 1343102.
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    376. Ohara A, Anklesaria P, Shultz L, Greenberger JS. Isolation of permanent clonal bone marrow stromal cell lines derived from "viable moth-eaten" and "severe combined immunodeficiency" mutant mice. Int J Cell Cloning. 1992 Jan; 10(1):33-46. PMID: 1552224.
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    377. Martin A, Kimura H, Thung S, Fong P, Shultz LD, Davies TF. Characteristics of long-term human thyroid peroxidase autoantibody secretion in scid mice transplanted with lymphocytes from patients with autoimmune thyroiditis. Int Arch Allergy Immunol. 1992; 98(4):317-23. PMID: 1422261.
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    378. Hayes SM, Shultz LD, Greiner DL. Thymic involution in viable motheaten (me(v)) mice is associated with a loss of intrathymic precursor activity. Dev Immunol. 1992; 2(3):191-205. PMID: 1627951.
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    379. Shultz LD. Hematopoiesis and models of immunodeficiency. Semin Immunol. 1991 Nov; 3(6):397-408. PMID: 1799670.
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    380. Shultz LD, Lane PW, Coman DR, Taylor S, Hall E, Lyons B, Wood BG, Schlager G. Hairpatches, a single gene mutation characterized by progressive renal disease and alopecia in the mouse. A potential model for a newly described heritable human disorder. Lab Invest. 1991 Nov; 65(5):588-600. PMID: 1836514.
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    381. Naito M, Hayashi S, Yoshida H, Nishikawa S, Shultz LD, Takahashi K. Abnormal differentiation of tissue macrophage populations in 'osteopetrosis' (op) mice defective in the production of macrophage colony-stimulating factor. Am J Pathol. 1991 Sep; 139(3):657-67. PMID: 1887865.
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    382. Koo GC, Manyak CL, Dasch J, Ellingsworth L, Shultz LD. Suppressive effects of monocytic cells and transforming growth factor-beta on natural killer cell differentiation in autoimmune viable motheaten mutant mice. J Immunol. 1991 Aug 15; 147(4):1194-200. PMID: 1714475.
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    383. Greiner DL, Shultz LD, Rossini AA, Mordes JP, Handler ES, Rajan TV. Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras. J Clin Invest. 1991 Aug; 88(2):717-9. PMID: 1864981.
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    384. Davies TF, Kimura H, Fong P, Kendler D, Shultz LD, Thung S, Martin A. The SCID-hu mouse and thyroid autoimmunity: characterization of human thyroid autoantibody secretion. Clin Immunol Immunopathol. 1991 Aug; 60(2):319-30. PMID: 2070573.
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    385. Shultz LD. Immunological mutants of the mouse. Am J Anat. 1991 Jul; 191(3):303-11. PMID: 1927974.
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    386. Schweitzer PA, Taylor SE, Shultz LD. Synthesis of abnormal immunoglobulins by hybridomas from autoimmune "viable motheaten" mutant mice. J Cell Biol. 1991 Jul; 114(1):35-43. PMID: 1646823.
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    387. Nelson FK, Greiner DL, Shultz LD, Rajan TV. The immunodeficient scid mouse as a model for human lymphatic filariasis. J Exp Med. 1991 Mar 1; 173(3):659-63. PMID: 1997651.
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    388. Kolber DL, Shultz LD, Rothstein TL. Phorbol ester responsiveness of murine Ly-1-lineage B cells from normal and viable motheaten mutant mice. Eur J Immunol. 1991 Mar; 21(3):721-9. PMID: 2009913.
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    389. Croitoru K, Stead RH, Bienenstock J, Shultz LD, Ernst PB. T cell receptor expression is not required for the localization and differentiation of intraepithelial lymphocytes. Immunol Res. 1991; 10(3-4):293-5. PMID: 1835481.
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    390. Sundberg JP, Beamer WG, Shultz LD, Dunstan RW. Inherited mouse mutations as models of human adnexal, cornification, and papulosquamous dermatoses. J Invest Dermatol. 1990 Nov; 95(5 Suppl):62S-63S. PMID: 16788637.
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    391. Yoshida H, Hayashi S, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD, Nishikawa S. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature. 1990 May 31; 345(6274):442-4. PMID: 2188141.
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    392. Croitoru K, Stead RH, Bienenstock J, Fulop G, Harnish DG, Shultz LD, Jeffery PK, Ernst PB. Presence of intestinal intraepithelial lymphocytes in mice with severe combined immunodeficiency disease. Eur J Immunol. 1990 Mar; 20(3):645-51. PMID: 1690660.
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    393. Serreze DV, Leiter EH, Shultz LD. Transplantation analysis of B cell destruction in (NOD x CBA)F1 mouse bone marrow chimeras. Diabetologia. 1990 Feb; 33(2):84-92. PMID: 2109714.
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    394. Sprecher E, Becker Y, Kraal G, Hall E, Harrison D, Shultz LD. Effect of aging on epidermal dendritic cell populations in C57BL/6J mice. J Invest Dermatol. 1990 Feb; 94(2):247-53. PMID: 2299200.
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    395. Sprecher E, Becker Y, Kraal G, Hall E, Shultz LD. Effect of genetically determined immunodeficiency on epidermal dendritic cell populations in C57BL/6J mice. Arch Dermatol Res. 1990; 282(3):188-93. PMID: 2196000.
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    396. Tennent BJ, Beamer WG, Shultz LD, Adamson ED. Epidermal growth factor receptors in spontaneous ovarian granulosa cell tumors of SWR-derived mice. Int J Cancer. 1989 Sep 15; 44(3):477-82. PMID: 2789196.
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    397. Sundberg JP, Burnstein T, Shultz LD, Bedigian H. Identification of Pneumocystis carinii in immunodeficient mice. Lab Anim Sci. 1989 May; 39(3):213-8. PMID: 2470952.
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    398. Van Zant G, Shultz L. Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev). Exp Hematol. 1989 Feb; 17(2):81-7. PMID: 2783574.
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    399. Willis EH, Carson DA, Shultz LD. Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation. Adv Exp Med Biol. 1989; 253B:209-12. PMID: 2610115.
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    400. Walzer PD, Kim CK, Linke MJ, Pogue CL, Huerkamp MJ, Chrisp CE, Lerro AV, Wixson SK, Hall E, Shultz LD. Outbreaks of Pneumocystis carinii pneumonia in colonies of immunodeficient mice. Infect Immun. 1989 Jan; 57(1):62-70. PMID: 2642471.
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    401. Shultz LD, Schweitzer PA, Hall EJ, Sundberg JP, Taylor S, Walzer PD. Pneumocystis carinii pneumonia in scid/scid mice. Curr Top Microbiol Immunol. 1989; 152:243-9. PMID: 2805792.
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    402. Bosma GC, Davisson MT, Ruetsch NR, Sweet HO, Shultz LD, Bosma MJ. The mouse mutation severe combined immune deficiency (scid) is on chromosome 16. Immunogenetics. 1989; 29(1):54-7. PMID: 2908877.
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    403. Haar JL, Popp JD, Shultz LD. Defective in vitro migratory capacity of bone marrow cells from viable motheaten mice in response to normal thymus culture supernatants. Exp Hematol. 1989 Jan; 17(1):21-4. PMID: 2562796.
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    404. McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science. 1988 Sep 23; 241(4873):1632-9. PMID: 2971269.
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    405. Beamer WG, Tennent BJ, Shultz KL, Nadeau JH, Shultz LD, Skow LC. Gene for ovarian granulosa cell tumor susceptibility, Gct, in SWXJ recombinant inbred strains of mice revealed by dehydroepiandrosterone. Cancer Res. 1988 Sep 15; 48(18):5092-5. PMID: 2970296.
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    406. Hayashi S, Witte PL, Shultz LD, Kincade PW. Lymphohemopoiesis in culture is prevented by interaction with adherent bone marrow cells from mutant viable motheaten mice. J Immunol. 1988 Apr 1; 140(7):2139-47. PMID: 2450912.
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    407. Serreze DV, Leiter EH, Worthen SM, Shultz LD. NOD marrow stem cells adoptively transfer diabetes to resistant (NOD x NON)F1 mice. Diabetes. 1988 Feb; 37(2):252-5. PMID: 3134263.
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    408. Schweitzer PA, Shultz LD. Characterization of Mott cell hybridomas from autoimmune "viable motheaten" mutant mice. Curr Top Microbiol Immunol. 1988; 137:223-6. PMID: 2843321.
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    409. Shultz LD. Pleiotropic effects of deleterious alleles at the "motheaten" locus. Curr Top Microbiol Immunol. 1988; 137:216-22. PMID: 3416633.
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    410. Evans R, Duffy TM, Shultz LD. The immunological mouse mutants nude (nu) and rhino (hrrh) generate cytotoxic effector cells following adoptive immunotherapy but fail to reject a transplanted tumor. Cancer Immunol Immunother. 1988; 26(1):35-42. PMID: 3257902.
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    411. Komschlies KL, Greiner DL, Shultz L, Goldschneider I. Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer. J Exp Med. 1987 Oct 1; 166(4):1162-7. PMID: 3498788.
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    412. Medlock ES, Goldschneider I, Greiner DL, Shultz L. Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. II. Description of a microenvironmental defect for the generation of terminal deoxynucleotidyltransferase-positive bone marrow cells in vitro. J Immunol. 1987 Jun 1; 138(11):3590-7. PMID: 3584969.
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    413. Willis EH, Carson DA, Shultz LD. Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation. Biochem Biophys Res Commun. 1987 May 29; 145(1):581-5. PMID: 3297058.
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    414. Leiter EH, Prochazka M, Shultz LD. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J Immunol. 1987 May 15; 138(10):3224-9. PMID: 3553324.
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    415. Shultz LD, Coman DR, Lyons BL, Sidman CL, Taylor S. Development of plasmacytoid cells with Russell bodies in autoimmune "viable motheaten" mice. Am J Pathol. 1987 Apr; 127(1):38-50. PMID: 3551623.
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    416. Shultz LD, Sidman CL. Genetically determined murine models of immunodeficiency. Annu Rev Immunol. 1987; 5:367-403. PMID: 3297105.
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    417. Leiter EH, Beamer WG, Shultz LD, Barker JE, Lane PW. Mouse models of genetic diseases. Birth Defects Orig Artic Ser. 1987; 23(3):221-57. PMID: 3307936.
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    418. Shultz LD. Pleiotropic mutations causing abnormalities in the murine immune system and the skin. Curr Probl Dermatol. 1987; 17:236-50. PMID: 3595190.
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    419. Inoue T, Aikawa K, Tezuka H, Kada T, Shultz LD. Effect of DNA-damaging agents on isolated spleen cells and lung fibroblasts from the mouse mutant "wasted," a putative animal model for ataxia-telangiectasia. Cancer Res. 1986 Aug; 46(8):3979-82. PMID: 2425937.
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    420. Sidman CL, Shultz LD, Hardy RR, Hayakawa K, Herzenberg LA. Production of immunoglobulin isotypes by Ly-1+ B cells in viable motheaten and normal mice. Science. 1986 Jun 13; 232(4756):1423-5. PMID: 3487115.
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    421. Tezuka H, Inoue T, Noguti T, Kada T, Shultz LD. Evaluation of the mouse mutant "wasted" as an animal model for ataxia telangiectasia. I. Age-dependent and tissue-specific effects. Mutat Res. 1986 Jun; 161(1):83-90. PMID: 3702898.
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    422. Hagiya M, Davis DD, Shultz LD, Sakano H. Non-germ-line elements (NGE) are present in the T cell receptor beta-chain genes isolated from the mutant mouse, motheaten (me/me). J Immunol. 1986 Apr 1; 136(7):2697-700. PMID: 3081652.
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    423. Inoue T, Tezuka H, Kada T, Aikawa K, Shultz LD. The mouse mutant "wasted": an animal model for ataxia-telangiectasia. Basic Life Sci. 1986; 39:323-35. PMID: 2429649.
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    424. Outzen HC, Corrow D, Shultz LD. Attenuation of exogenous murine mammary tumor virus virulence in the C3H/HeJ mouse substrain bearing the Lps mutation. J Natl Cancer Inst. 1985 Nov; 75(5):917-23. PMID: 2997536.
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    425. Sidman CL, Shultz LD, Evans R. A serum-derived molecule from autoimmune viable motheaten mice potentiates the action of a B cell maturation factor. J Immunol. 1985 Aug; 135(2):870-2. PMID: 3891855.
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    426. Gershwin ME, Shultz L. Mechanisms of genetically determined immune dysfunction. Immunol Today. 1985 Feb; 6(2):36-7. PMID: 25291387.
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    427. Sidman CL, Marshall JD, Masiello NC, Roths JB, Shultz LD. Novel B-cell maturation factor from spontaneously autoimmune viable motheaten mice. Proc Natl Acad Sci U S A. 1984 Nov; 81(22):7199-202. PMID: 6334306.
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    428. Shultz LD, Coman DR, Bailey CL, Beamer WG, Sidman CL. "Viable motheaten," a new allele at the motheaten locus. I. Pathology. Am J Pathol. 1984 Aug; 116(2):179-92. PMID: 6380298.
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    429. Nordeen SK, Schaefer VG, Edgell MH, Hutchison CA, Shultz LD, Swift M. Evaluations of wasted mouse fibroblasts and SV-40 transformed human fibroblasts as models of ataxia telangiectasia in vitro. Mutat Res. 1984 Aug; 140(4):219-22. PMID: 6206393.
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    430. Sidman CL, Marshall JD, Shultz LD, Gray PW, Johnson HM. Gamma-interferon is one of several direct B cell-maturing lymphokines. Nature. 1984 Jun 28-Jul 4; 309(5971):801-4. PMID: 6429547.
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    431. Shultz LD, Bailey CL, Coman DR. Hematopoietic stem cell function in motheaten mice. Exp Hematol. 1983 Aug; 11(7):667-80. PMID: 6350031.
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    432. Leiter EH, Beamer WG, Shultz LD. The effect of immunosuppression on streptozotocin-induced diabetes in C57BL/KsJ mice. Diabetes. 1983 Feb; 32(2):148-55. PMID: 6219026.
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    433. Grzanna R, Shultz LD. The contribution of mast cells to the histamine content of the central nervous system: a regional analysis. Life Sci. 1982 Jun 7; 30(23):1959-64. PMID: 7109831.
      View in: PubMed
    434. Shultz LD, Sweet HO, Davisson MT, Coman DR. 'Wasted', a new mutant of the mouse with abnormalities characteristic to ataxia telangiectasia. Nature. 1982 Jun 3; 297(5865):402-4. PMID: 7078649.
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    435. Johnson DA, Shultz LD, Bedigian HG. Immunodeficiency and reticulum cell sarcoma in mice segregating for HRS/J and SJL/J genes. Leuk Res. 1982; 6(5):711-20. PMID: 6296551.
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    436. Clark EA, Shultz LD, Pollack SB. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics. 1981 Mar 1; 12(5-6):601-13. PMID: 6971254.
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    437. Sidman CL, Shultz LD, Unanue ER. The mouse mutant "motheaten." II. Functional studies of the immune system. J Immunol. 1978 Dec; 121(6):2399-404. PMID: 363947.
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    438. Sidman CL, Shultz LD, Unanue ER. The mouse mutant "motheaten". I. Development of lymphocyte populations. J Immunol. 1978 Dec; 121(6):2392-8. PMID: 363946.
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    439. Shultz LD, Green MC. Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins. J Immunol. 1976 Apr; 116(4):936-43. PMID: 56406.
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    440. Green MC, Shultz LD. Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology. J Hered. 1975 Sep-Oct; 66(5):250-8. PMID: 1184950.
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    441. Green MC, Shultz LD, Nedzi LA. Abnormal nuclear morphology of leukocytes in the mouse mutant ichthyosis. Transplantation. 1975 Aug; 20(2):172-5. PMID: 1101484.
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    442. Shultz LD, Wilder MS. Fate of listeria monocytogenes in normal rabbit serum. Infect Immun. 1973 Feb; 7(2):289-97. PMID: 4633292.
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    443. Shultz LD, Wilder MS. Cytotoxicity of rabbit blood for Listeria monocytogenes. Infect Immun. 1971 Dec; 4(6):703-8. PMID: 5005312.
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