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Juleen R Zierath PhD

TitleAdjunct Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentProgram in Molecular Medicine
AddressKarolinska Institutet, Department of Molecular Medicine
von Eulers vag 4a, IV, S-171 77
Stockholm
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine


    Collapse Biography 
    Collapse education and training
    University of Wisconsin River Falls, River Falls, WI, United StatesBSPhysical Education
    Ball State University, Muncie, IN, United StatesMAExercise Science
    Karolinska Institute, Solna, , SwedenPHDPhysiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Massart J, Sjögren RJ, Lundell LS, Mudry JM, Franck N, O'Gorman DJ, Egan B, Zierath JR, Krook A. Altered miRNA-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle. Diabetes. 2017 Apr 12. PMID: 28404597.
      View in: PubMed
    2. Mannerås-Holm L, Schönke M, Brozinick JT, Vetterli L, Bui HH, Sanders P, Nascimento EBM, Björnholm M, Chibalin AV, Zierath JR. Diacylglycerol kinase e deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice. J Lipid Res. 2017 May; 58(5):907-915. PMID: 28246337.
      View in: PubMed
    3. Ruby MA, Massart J, Hunerdosse DM, Schönke M, Correia JC, Louie SM, Ruas JL, Näslund E, Nomura DK, Zierath JR. Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance. Cell Rep. 2017 Jan 17; 18(3):636-646. PMID: 28099843.
      View in: PubMed
    4. Mudry JM, Lassiter DG, Nylén C, García-Calzón S, Näslund E, Krook A, Zierath JR. Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle. Diabetes. 2016 Dec 23. PMID: 28011458.
      View in: PubMed
    5. Zierath JR. Building Bridges through Scientific Conferences. Cell. 2016 Nov 17; 167(5):1155-1158. PMID: 27863234.
      View in: PubMed
    6. Kjøbsted R, Munk-Hansen N, Birk JB, Foretz M, Viollet B, Björnholm M, Zierath JR, Treebak JT, Wojtaszewski JF. Enhanced Muscle Insulin Sensitivity After Contraction/Exercise is Mediated by AMPK. Diabetes. 2016 Oct 26. PMID: 27797909.
      View in: PubMed
    7. Egan B, Hawley JA, Zierath JR. SnapShot: Exercise Metabolism. Cell Metab. 2016 Aug 9; 24(2):342-342.e1. PMID: 27508878.
      View in: PubMed
    8. Cartee GD, Hepple RT, Bamman MM, Zierath JR. Exercise Promotes Healthy Aging of Skeletal Muscle. Cell Metab. 2016 Jun 14; 23(6):1034-47. PMID: 27304505.
      View in: PubMed
    9. Mudry JM, Alm PS, Erhardt S, Goiny M, Fritz T, Caidahl K, Zierath JR, Krook A, Wallberg-Henriksson H. Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes. Diabetes Metab Res Rev. 2016 Oct; 32(7):754-761. PMID: 26946084.
      View in: PubMed
    10. Riedl I, Osler ME, Björnholm M, Egan B, Nader GA, Chibalin AV, Zierath JR. AMPK?3 is dispensable for skeletal muscle hypertrophy induced by functional overload. Am J Physiol Endocrinol Metab. 2016 Mar 15; 310(6):E461-72. PMID: 26758685.
      View in: PubMed
    11. Kirchner H, Sinha I, Gao H, Ruby MA, Schönke M, Lindvall JM, Barrès R, Krook A, Näslund E, Dahlman-Wright K, Zierath JR. Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients. Mol Metab. 2016 Mar; 5(3):171-83. PMID: 26977391.
      View in: PubMed
    12. Donkin I, Versteyhe S, Ingerslev LR, Qian K, Mechta M, Nordkap L, Mortensen B, Appel EV, Jørgensen N, Kristiansen VB, Hansen T, Workman CT, Zierath JR, Barrès R. Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans. Cell Metab. 2016 Feb 09; 23(2):369-78. PMID: 26669700.
      View in: PubMed
    13. Zierath JR. Erratum to: Turning the page. Diabetologia. 2015 Dec; 58(12):2899. PMID: 26471902.
      View in: PubMed
    14. Zierath JR. Turning the page. Diabetologia. 2015 Dec; 58(12):2685-7. PMID: 26407714.
      View in: PubMed
    15. Boon H, Sjögren RJ, Massart J, Egan B, Kostovski E, Iversen PO, Hjeltnes N, Chibalin AV, Widegren U, Zierath JR. MicroRNA-208b progressively declines after spinal cord injury in humans and is inversely related to myostatin expression. Physiol Rep. 2015 Nov; 3(11). PMID: 26603456.
      View in: PubMed
    16. Jiang LQ, de Castro Barbosa T, Massart J, Deshmukh AS, Löfgren L, Duque-Guimaraes DE, Ozilgen A, Osler ME, Chibalin AV, Zierath JR. Diacylglycerol kinase-d regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics. Am J Physiol Endocrinol Metab. 2016 Jan 01; 310(1):E51-60. PMID: 26530149.
      View in: PubMed
    17. Correia JC, Massart J, de Boer JF, Porsmyr-Palmertz M, Martínez-Redondo V, Agudelo LZ, Sinha I, Meierhofer D, Ribeiro V, Björnholm M, Sauer S, Dahlman-Wright K, Zierath JR, Groen AK, Ruas JL. Bioenergetic cues shift FXR splicing towards FXRa2 to modulate hepatic lipolysis and fatty acid metabolism. Mol Metab. 2015 Dec; 4(12):891-902. PMID: 26909306.
      View in: PubMed
    18. Schönke M, Myers MG, Zierath JR, Björnholm M. Skeletal muscle AMP-activated protein kinase ?1(H151R) overexpression enhances whole body energy homeostasis and insulin sensitivity. Am J Physiol Endocrinol Metab. 2015 Oct 01; 309(7):E679-90. PMID: 26306597.
      View in: PubMed
    19. Zierath JR. Diabetologia at 50: celebrating half a century of progress in diabetes research and care. Diabetologia. 2015 Aug; 58(8):1685-7. PMID: 26013681.
      View in: PubMed
    20. Cedernaes J, Osler ME, Voisin S, Broman JE, Vogel H, Dickson SL, Zierath JR, Schiöth HB, Benedict C. Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men. J Clin Endocrinol Metab. 2015 Sep; 100(9):E1255-61. PMID: 26168277.
      View in: PubMed
    21. Zierath JR, Wallberg-Henriksson H. Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us? Cell Metab. 2015 Jul 7; 22(1):25-30. PMID: 26154051.
      View in: PubMed
    22. Ring M, Eriksson MJ, Fritz T, Nyberg G, Östenson CG, Krook A, Zierath JR, Caidahl K. Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance. Diab Vasc Dis Res. 2015 Sep; 12(5):315-24. PMID: 26092821.
      View in: PubMed
    23. Mannerås-Holm L, Kirchner H, Björnholm M, Chibalin AV, Zierath JR. mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance. Physiol Rep. 2015 Apr; 3(4). PMID: 25847921.
      View in: PubMed
    24. Osler ME, Fritz T, Caidahl K, Krook A, Zierath JR, Wallberg-Henriksson H. Changes in gene expression in responders and nonresponders to a low-intensity walking intervention. Diabetes Care. 2015 Jun; 38(6):1154-60. PMID: 25795414.
      View in: PubMed
    25. Riedl I, Osler ME, Benziane B, Chibalin AV, Zierath JR. Association of the ACTN3 R577X polymorphism with glucose tolerance and gene expression of sarcomeric proteins in human skeletal muscle. Physiol Rep. 2015 Mar; 3(3). PMID: 25780092.
      View in: PubMed
    26. Wallberg-Henriksson H, Zierath JR. Metabolism. Exercise remodels subcutaneous fat tissue and improves metabolism. Nat Rev Endocrinol. 2015 Apr; 11(4):198-200. PMID: 25707778.
      View in: PubMed
    27. Multhaup ML, Seldin MM, Jaffe AE, Lei X, Kirchner H, Mondal P, Li Y, Rodriguez V, Drong A, Hussain M, Lindgren C, McCarthy M, Näslund E, Zierath JR, Wong GW, Feinberg AP. Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metab. 2015 Jan 6; 21(1):138-49. PMID: 25565211.
      View in: PubMed
    28. Sjögren RJ, Egan B, Katayama M, Zierath JR, Krook A. Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells. Physiol Genomics. 2015 Mar; 47(3):45-57. PMID: 25547110.
      View in: PubMed
    29. Hawley JA, Hargreaves M, Joyner MJ, Zierath JR. Integrative biology of exercise. Cell. 2014 Nov 6; 159(4):738-49. PMID: 25417152.
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    30. Pirkmajer S, Kulkarni SS, Tom RZ, Ross FA, Hawley SA, Hardie DG, Zierath JR, Chibalin AV. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation. Diabetes. 2015 Feb; 64(2):360-9. PMID: 25338814.
      View in: PubMed
    31. Agudelo LZ, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DM, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL. Skeletal muscle PGC-1a1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell. 2014 Sep 25; 159(1):33-45. PMID: 25259918.
      View in: PubMed
    32. Al-Khalili L, de Castro Barbosa T, Ostling J, Massart J, Cuesta PG, Osler ME, Katayama M, Nyström AC, Oscarsson J, Zierath JR. Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes. Am J Physiol Cell Physiol. 2014 Nov 1; 307(9):C774-87. PMID: 25143351.
      View in: PubMed
    33. Ring M, Eriksson MJ, Zierath JR, Caidahl K. Arterial stiffness estimation in healthy subjects: a validation of oscillometric (Arteriograph) and tonometric (SphygmoCor) techniques. Hypertens Res. 2014 Nov; 37(11):999-1007. PMID: 25056681.
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    34. Moltke I, Grarup N, Jørgensen ME, Bjerregaard P, Treebak JT, Fumagalli M, Korneliussen TS, Andersen MA, Nielsen TS, Krarup NT, Gjesing AP, Zierath JR, Linneberg A, Wu X, Sun G, Jin X, Al-Aama J, Wang J, Borch-Johnsen K, Pedersen O, Nielsen R, Albrechtsen A, Hansen T. A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes. Nature. 2014 Aug 14; 512(7513):190-3. PMID: 25043022.
      View in: PubMed
    35. Rasmussen M, Zierath JR, Barrès R. Dynamic epigenetic responses to muscle contraction. Drug Discov Today. 2014 Jul; 19(7):1010-4. PMID: 24631681.
      View in: PubMed
    36. Zachariah Tom R, Garcia-Roves PM, Sjögren RJ, Jiang LQ, Holmström MH, Deshmukh AS, Vieira E, Chibalin AV, Björnholm M, Zierath JR. Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice. Diabetes. 2014 May; 63(5):1560-71. PMID: 24487023.
      View in: PubMed
    37. Kirchner H, Nylen C, Laber S, Barrès R, Yan J, Krook A, Zierath JR, Näslund E. Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass. Surg Obes Relat Dis. 2014 Jul-Aug; 10(4):671-8. PMID: 24837562.
      View in: PubMed
    38. Nascimento EB, Osler ME, Zierath JR. Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle. Am J Physiol Endocrinol Metab. 2013 Dec 1; 305(11):E1408-14. PMID: 24129397.
      View in: PubMed
    39. Jiang LQ, Franck N, Egan B, Sjögren RJ, Katayama M, Duque-Guimaraes D, Arner P, Zierath JR, Krook A. Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7. Am J Physiol Endocrinol Metab. 2013 Dec 1; 305(11):E1359-66. PMID: 24105413.
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    40. Egan B, O'Connor PL, Zierath JR, O'Gorman DJ. Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle. PLoS One. 2013; 8(9):e74098. PMID: 24069271.
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    41. Brandauer J, Vienberg SG, Andersen MA, Ringholm S, Risis S, Larsen PS, Kristensen JM, Frøsig C, Leick L, Fentz J, Jørgensen S, Kiens B, Wojtaszewski JF, Richter EA, Zierath JR, Goodyear LJ, Pilegaard H, Treebak JT. AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle. J Physiol. 2013 Oct 15; 591(20):5207-20. PMID: 23918774.
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    42. Dokas J, Chadt A, Nolden T, Himmelbauer H, Zierath JR, Joost HG, Al-Hasani H. Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle. Endocrinology. 2013 Oct; 154(10):3502-14. PMID: 23892475.
      View in: PubMed
    43. Cansby E, Amrutkar M, Mannerås Holm L, Nerstedt A, Reyahi A, Stenfeldt E, Borén J, Carlsson P, Smith U, Zierath JR, Mahlapuu M. Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet. FASEB J. 2013 Sep; 27(9):3660-71. PMID: 23729594.
      View in: PubMed
    44. Holmström MH, Tom RZ, Björnholm M, Garcia-Roves PM, Zierath JR. Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice. Metabolism. 2013 Sep; 62(9):1258-67. PMID: 23664724.
      View in: PubMed
    45. Barres R, Kirchner H, Rasmussen M, Yan J, Kantor FR, Krook A, Näslund E, Zierath JR. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep. 2013 Apr 25; 3(4):1020-7. PMID: 23583180.
      View in: PubMed
    46. Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013 Feb 5; 17(2):162-84. PMID: 23395166.
      View in: PubMed
    47. Fritz T, Caidahl K, Krook A, Lundström P, Mashili F, Osler M, Szekeres FL, Östenson CG, Wändell P, Zierath JR. Effects of Nordic walking on cardiovascular risk factors in overweight individuals with type 2 diabetes, impaired or normal glucose tolerance. Diabetes Metab Res Rev. 2013 Jan; 29(1):25-32. PMID: 22887834.
      View in: PubMed
    48. Jiang LQ, Duque-Guimaraes DE, Machado UF, Zierath JR, Krook A. Altered response of skeletal muscle to IL-6 in type 2 diabetic patients. Diabetes. 2013 Feb; 62(2):355-61. PMID: 23086036.
      View in: PubMed
    49. Mashili F, Chibalin AV, Krook A, Zierath JR. Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes. 2013 Feb; 62(2):457-65. PMID: 23043161.
      View in: PubMed
    50. Szekeres F, Chadt A, Tom RZ, Deshmukh AS, Chibalin AV, Björnholm M, Al-Hasani H, Zierath JR. The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism. Am J Physiol Endocrinol Metab. 2012 Aug 15; 303(4):E524-33. PMID: 22693207.
      View in: PubMed
    51. Benziane B, Björnholm M, Pirkmajer S, Austin RL, Kotova O, Viollet B, Zierath JR, Chibalin AV. Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells. J Biol Chem. 2012 Jul 6; 287(28):23451-63. PMID: 22610379.
      View in: PubMed
    52. Barrès R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, O'Gorman DJ, Zierath JR. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012 Mar 7; 15(3):405-11. PMID: 22405075.
      View in: PubMed
    53. Holmström MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM. Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab. 2012 Mar 15; 302(6):E731-9. PMID: 22252943.
      View in: PubMed
    54. Fritz T, Caidahl K, Osler M, Ostenson CG, Zierath JR, Wändell P. Effects of Nordic walking on health-related quality of life in overweight individuals with type 2 diabetes mellitus, impaired or normal glucose tolerance. Diabet Med. 2011 Nov; 28(11):1362-72. PMID: 21658122.
      View in: PubMed
    55. Zierath JR. Remembering our classics: then and now. Diabetologia. 2012 Jan; 55(1):1-2. PMID: 22038521.
      View in: PubMed
    56. Yan J, Zierath JR, Barrès R. Evidence for non-CpG methylation in mammals. Exp Cell Res. 2011 Nov 1; 317(18):2555-61. PMID: 21925168.
      View in: PubMed
    57. Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR. Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. J Biol Chem. 2011 Oct 7; 286(40):34567-74. PMID: 21873433.
      View in: PubMed
    58. Kulkarni SS, Salehzadeh F, Fritz T, Zierath JR, Krook A, Osler ME. Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus. Metabolism. 2012 Feb; 61(2):175-85. PMID: 21816445.
      View in: PubMed
    59. Zierath JR, Barrès RE. Nutritional status affects the epigenomic profile of peripheral blood cells. Epigenomics. 2011 Jun; 3(3):259-60. PMID: 22122335.
      View in: PubMed
    60. Mashili FL, Austin RL, Deshmukh AS, Fritz T, Caidahl K, Bergdahl K, Zierath JR, Chibalin AV, Moller DE, Kharitonenkov A, Krook A. Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity. Diabetes Metab Res Rev. 2011 Mar; 27(3):286-97. PMID: 21309058.
      View in: PubMed
    61. Vind BF, Pehmøller C, Treebak JT, Birk JB, Hey-Mogensen M, Beck-Nielsen H, Zierath JR, Wojtaszewski JF, Højlund K. Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training. Diabetologia. 2011 Jan; 54(1):157-67. PMID: 20938636.
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    62. Feng X, Yan J, Wang Y, Zierath JR, Nordenskjöld M, Henter JI, Fadeel B, Zheng C. The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells. Mol Immunol. 2010 Aug; 47(14):2388-96. PMID: 20542572.
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    63. Sogaard P, Szekeres F, Garcia-Roves PM, Larsson D, Chibalin AV, Zierath JR. Spatial insulin signalling in isolated skeletal muscle preparations. J Cell Biochem. 2010 Apr 1; 109(5):943-9. PMID: 20069552.
      View in: PubMed
    64. Deshmukh AS, Long YC, de Castro Barbosa T, Karlsson HK, Glund S, Zavadoski WJ, Gibbs EM, Koistinen HA, Wallberg-Henriksson H, Zierath JR. Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)alpha1-specific activity and glucose transport in human skeletal muscle. Diabetologia. 2010 Jun; 53(6):1142-50. PMID: 20349036.
      View in: PubMed
    65. Cantó C, Jiang LQ, Deshmukh AS, Mataki C, Coste A, Lagouge M, Zierath JR, Auwerx J. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 2010 Mar 3; 11(3):213-9. PMID: 20197054.
      View in: PubMed
    66. Jiang LQ, Garcia-Roves PM, de Castro Barbosa T, Zierath JR. Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity. Am J Physiol Endocrinol Metab. 2010 Jan; 298(1):E8-E16. PMID: 19861587.
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    67. Benziane B, Björnholm M, Lantier L, Viollet B, Zierath JR, Chibalin AV. AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase. Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1554-66. PMID: 19828836.
      View in: PubMed
    68. Deshmukh AS, Glund S, Tom RZ, Zierath JR. Role of the AMPKgamma3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscle. Am J Physiol Endocrinol Metab. 2009 Dec; 297(6):E1388-94. PMID: 19826102.
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    69. Barrès R, Osler ME, Yan J, Rune A, Fritz T, Caidahl K, Krook A, Zierath JR. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab. 2009 Sep; 10(3):189-98. PMID: 19723495.
      View in: PubMed
    70. Rune A, Osler ME, Fritz T, Zierath JR. Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes. Diabetologia. 2009 Oct; 52(10):2182-9. PMID: 19652946.
      View in: PubMed
    71. Wallberg-Henriksson H, Zierath JR. A new twist on brown fat metabolism. Cell. 2009 Apr 3; 137(1):22-4. PMID: 19345181.
      View in: PubMed
    72. Krook A, Zierath JR. Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA. Diabetologia. 2009 Jul; 52(7):1231-9. PMID: 19333572.
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    73. Sultan A, Strodthoff D, Robertson AK, Paulsson-Berne G, Fauconnier J, Parini P, Rydén M, Thierry-Mieg N, Johansson ME, Chibalin AV, Zierath JR, Arner P, Hansson GK. T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice. Circ Res. 2009 Apr 24; 104(8):961-8. PMID: 19299644.
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    74. Treebak JT, Frøsig C, Pehmøller C, Chen S, Maarbjerg SJ, Brandt N, MacKintosh C, Zierath JR, Hardie DG, Kiens B, Richter EA, Pilegaard H, Wojtaszewski JF. Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle. Diabetologia. 2009 May; 52(5):891-900. PMID: 19252894.
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    75. Karlsson HK, Chibalin AV, Koistinen HA, Yang J, Koumanov F, Wallberg-Henriksson H, Zierath JR, Holman GD. Kinetics of GLUT4 trafficking in rat and human skeletal muscle. Diabetes. 2009 Apr; 58(4):847-54. PMID: 19188436.
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    76. Benziane B, Burton TJ, Scanlan B, Galuska D, Canny BJ, Chibalin AV, Zierath JR, Stepto NK. Divergent cell signaling after short-term intensified endurance training in human skeletal muscle. Am J Physiol Endocrinol Metab. 2008 Dec; 295(6):E1427-38. PMID: 18827172.
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    77. Glund S, Treebak JT, Long YC, Barres R, Viollet B, Wojtaszewski JF, Zierath JR. Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle. Endocrinology. 2009 Feb; 150(2):600-6. PMID: 18818284.
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    78. Deshmukh AS, Hawley JA, Zierath JR. Exercise-induced phospho-proteins in skeletal muscle. Int J Obes (Lond). 2008 Sep; 32 Suppl 4:S18-23. PMID: 18719593.
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    79. Lundholm L, Bryzgalova G, Gao H, Portwood N, Fält S, Berndt KD, Dicker A, Galuska D, Zierath JR, Gustafsson JA, Efendic S, Dahlman-Wright K, Khan A. The estrogen receptor {alpha}-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms. J Endocrinol. 2008 Nov; 199(2):275-86. PMID: 18757549.
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    80. Vieira E, Nilsson EC, Nerstedt A, Ormestad M, Long YC, Garcia-Roves PM, Zierath JR, Mahlapuu M. Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle. Am J Physiol Endocrinol Metab. 2008 Nov; 295(5):E1032-7. PMID: 18728219.
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    81. Cabrera O, Jacques-Silva MC, Speier S, Yang SN, Köhler M, Fachado A, Vieira E, Zierath JR, Kibbey R, Berman DM, Kenyon NS, Ricordi C, Caicedo A, Berggren PO. Glutamate is a positive autocrine signal for glucagon release. Cell Metab. 2008 Jun; 7(6):545-54. PMID: 18522835.
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    82. Austin RL, Rune A, Bouzakri K, Zierath JR, Krook A. siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. Diabetes. 2008 Aug; 57(8):2066-73. PMID: 18443205.
      View in: PubMed
    83. Bouzakri K, Austin R, Rune A, Lassman ME, Garcia-Roves PM, Berger JP, Krook A, Chibalin AV, Zhang BB, Zierath JR. Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes. 2008 Jun; 57(6):1508-16. PMID: 18314420.
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    84. Deshmukh AS, Treebak JT, Long YC, Viollet B, Wojtaszewski JF, Zierath JR. Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling. Mol Endocrinol. 2008 May; 22(5):1105-12. PMID: 18276828.
      View in: PubMed
    85. Chibalin AV, Leng Y, Vieira E, Krook A, Björnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nylén C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR. Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell. 2008 Feb 8; 132(3):375-86. PMID: 18267070.
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    86. Osler ME, Zierath JR. Fighting the battle of the bulge: exercise training in early-onset type 2 diabetes. Diabetologia. 2007 Jul; 50(7):1362-4. PMID: 17486312.
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    178. Zierath JR, Krook A, Wallberg-Henriksson H. Insulin action in skeletal muscle from patients with NIDDM. Mol Cell Biochem. 1998 May; 182(1-2):153-60. PMID: 9609124.
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    179. Chibalin AV, Zierath JR, Katz AI, Berggren PO, Bertorello AM. Phosphatidylinositol 3-kinase-mediated endocytosis of renal Na+, K+-ATPase alpha subunit in response to dopamine. Mol Biol Cell. 1998 May; 9(5):1209-20. PMID: 9571250.
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    180. Galuska D, Ryder J, Kawano Y, Charron MJ, Zierath JR. Insulin signaling and glucose transport in insulin resistant skeletal muscle. Special reference to GLUT4 transgenic and GLUT4 knockout mice. Adv Exp Med Biol. 1998; 441:73-85. PMID: 9781315.
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    181. Wallberg-Henriksson H, Rincon J, Zierath JR. Exercise in the management of non-insulin-dependent diabetes mellitus. Sports Med. 1998 Jan; 25(1):25-35. PMID: 9458525.
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    182. Zierath JR, Frevert EU, Ryder JW, Berggren PO, Kahn BB. Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes. Diabetes. 1998 Jan; 47(1):1-4. PMID: 9421367.
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    183. Lund S, Holman GD, Zierath JR, Rincon J, Nolte LA, Clark AE, Schmitz O, Pedersen O, Wallberg-Henriksson H. Effect of insulin on GLUT4 cell surface content and turnover rate in human skeletal muscle as measured by the exofacial bis-mannose photolabeling technique. Diabetes. 1997 Dec; 46(12):1965-9. PMID: 9392481.
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    184. Krook A, Kawano Y, Song XM, Efendic S, Roth RA, Wallberg-Henriksson H, Zierath JR. Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats. Diabetes. 1997 Dec; 46(12):2110-4. PMID: 9392506.
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    185. Shepherd PR, Nave BT, Rincon J, Haigh RJ, Foulstone E, Proud C, Zierath JR, Siddle K, Wallberg-Henriksson H. Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism. Diabetologia. 1997 Oct; 40(10):1172-7. PMID: 9349598.
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    186. Lund S, Pedersen O, Holman GD, Clark AE, Zierath JR, Wallberg-Henriksson H. GLUT4 translocation in human muscle strips. Biochem Soc Trans. 1997 Aug; 25(3):466S. PMID: 9388687.
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    187. Shepherd PR, Navé BT, Rincon J, Nolte LA, Bevan AP, Siddle K, Zierath JR, Wallberg-Henriksson H. Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle. J Biol Chem. 1997 Jul 25; 272(30):19000-7. PMID: 9228082.
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    188. Björnholm M, Kawano Y, Lehtihet M, Zierath JR. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes. 1997 Mar; 46(3):524-7. PMID: 9032113.
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    189. Zierath JR, He L, Gumà A, Odegoard Wahlström E, Klip A, Wallberg-Henriksson H. Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia. 1996 Oct; 39(10):1180-9. PMID: 8897005.
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    190. Aksnes AK, Hjeltnes N, Wahlström EO, Katz A, Zierath JR, Wallberg-Henriksson H. Intact glucose transport in morphologically altered denervated skeletal muscle from quadriplegic patients. Am J Physiol. 1996 Sep; 271(3 Pt 1):E593-600. PMID: 8843756.
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    191. Wahren J, Johansson BL, Wallberg-Henriksson H, Linde B, Fernqvist-Forbes E, Zierath JR. C-peptide revisited--new physiological effects and therapeutic implications. J Intern Med. 1996 Sep; 240(3):115-24. PMID: 8862120.
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    192. Rincon J, Holmäng A, Wahlström EO, Lönnroth P, Björntorp P, Zierath JR, Wallberg-Henriksson H. Mechanisms behind insulin resistance in rat skeletal muscle after oophorectomy and additional testosterone treatment. Diabetes. 1996 May; 45(5):615-21. PMID: 8621012.
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    193. Zierath JR, Handberg A, Tally M, Wallberg-Henriksson H. C-peptide stimulates glucose transport in isolated human skeletal muscle independent of insulin receptor and tyrosine kinase activation. Diabetologia. 1996 Mar; 39(3):306-13. PMID: 8721776.
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    194. Nolte LA, Rincón J, Wahlström EO, Craig BW, Zierath JR, Wallberg-Henriksson H. Hyperglycemia activates glucose transport in rat skeletal muscle via a Ca(2+)-dependent mechanism. Diabetes. 1995 Nov; 44(11):1345-8. PMID: 7589835.
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    195. Zierath JR, Nolte LA, Wahlström E, Galuska D, Shepherd PR, Kahn BB, Wallberg-Henriksson H. Carrier-mediated fructose uptake significantly contributes to carbohydrate metabolism in human skeletal muscle. Biochem J. 1995 Oct 15; 311 ( Pt 2):517-21. PMID: 7487889.
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    196. Gumà A, Zierath JR, Wallberg-Henriksson H, Klip A. Insulin induces translocation of GLUT-4 glucose transporters in human skeletal muscle. Am J Physiol. 1995 Apr; 268(4 Pt 1):E613-22. PMID: 7733259.
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    197. Nolte LA, Abdel-Halim SM, Martin IK, Guenifi A, Zierath JR, Ostenson CG, Wallberg-Henriksson H. Development of decreased insulin-induced glucose transport in skeletal muscle of glucose-intolerant hybrids of diabetic GK rats. Clin Sci (Lond). 1995 Mar; 88(3):301-6. PMID: 7736698.
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    198. Zierath JR. In vitro studies of human skeletal muscle: hormonal and metabolic regulation of glucose transport. Acta Physiol Scand Suppl. 1995; 626:1-96. PMID: 8525841.
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    199. Galuska D, Nolte L, Wahlström E, Smedegaard Kristensen JS, Wallberg-Henriksson H, Zierath JR. Effects of non-esterified fatty acids on insulin-stimulated glucose transport in isolated skeletal muscle from patients with type 2 (non-insulin-dependent) diabetes mellitus. Acta Diabetol. 1994 Sep; 31(3):169-72. PMID: 7827358.
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    200. Galuska D, Nolte LA, Zierath JR, Wallberg-Henriksson H. Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM. Diabetologia. 1994 Aug; 37(8):826-32. PMID: 7988785.
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    201. Nolte LA, Galuska D, Martin IK, Zierath JR, Wallberg-Henriksson H. Elevated free fatty acid levels inhibit glucose phosphorylation in slow-twitch rat skeletal muscle. Acta Physiol Scand. 1994 May; 151(1):51-9. PMID: 8048336.
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    202. Zierath JR, Galuska D, Nolte LA, Thörne A, Kristensen JS, Wallberg-Henriksson H. Effects of glycaemia on glucose transport in isolated skeletal muscle from patients with NIDDM: in vitro reversal of muscular insulin resistance. Diabetologia. 1994 Mar; 37(3):270-7. PMID: 8174841.
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    203. Norgren S, Zierath J, Wedell A, Wallberg-Henriksson H, Luthman H. Regulation of human insulin receptor RNA splicing in vivo. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1465-9. PMID: 8108432.
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    204. Johansson U, Eriksson LS, Galuska D, Zierath JR, Wallberg-Henriksson H. Insulin action on glucose transport in isolated skeletal muscle from patients with liver cirrhosis. Scand J Gastroenterol. 1994 Jan; 29(1):71-6. PMID: 8128180.
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    205. Norgren S, Zierath J, Galuska D, Wallberg-Henriksson H, Luthman H. Differences in the ratio of RNA encoding two isoforms of the insulin receptor between control and NIDDM patients. The RNA variant without Exon 11 predominates in both groups. Diabetes. 1993 May; 42(5):675-81. PMID: 7683288.
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    206. Zierath JR, Wallberg-Henriksson H. Exercise training in obese diabetic patients. Special considerations. Sports Med. 1992 Sep; 14(3):171-89. PMID: 1439393.
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    207. Zierath JR, Bang P, Galuska D, Hall K, Wallberg-Henriksson H. Insulin-like growth factor II stimulates glucose transport in human skeletal muscle. FEBS Lett. 1992 Aug 3; 307(3):379-82. PMID: 1379546.
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    208. Zierath JR, Galuska D, Engström A, Johnson KH, Betsholtz C, Westermark P, Wallberg-Henriksson H. Human islet amyloid polypeptide at pharmacological levels inhibits insulin and phorbol ester-stimulated glucose transport in in vitro incubated human muscle strips. Diabetologia. 1992 Jan; 35(1):26-31. PMID: 1541378.
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    209. Zierath JR, Galuska D, Johansson BL, Wallberg-Henriksson H. Effect of human C-peptide on glucose transport in in vitro incubated human skeletal muscle. Diabetologia. 1991 Dec; 34(12):899-901. PMID: 1778355.
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    210. Galuska D, Zierath J, Thörne A, Sonnenfeld T, Wallberg-Henriksson H. Metformin increases insulin-stimulated glucose transport in insulin-resistant human skeletal muscle. Diabete Metab. 1991 May; 17(1 Pt 2):159-63. PMID: 1936469.
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    211. Cartee GD, Young DA, Sleeper MD, Zierath J, Wallberg-Henriksson H, Holloszy JO. Prolonged increase in insulin-stimulated glucose transport in muscle after exercise. Am J Physiol. 1989 Apr; 256(4 Pt 1):E494-9. PMID: 2650561.
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