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Juleen R Zierath PhD

TitleAdjunct Professor
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressKarolinska Institutet, Department of Molecular Medicine
von Eulers vag 4a, IV, S-171 77
Stockholm
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine


    Collapse Biography 
    Collapse education and training
    University of Wisconsin River Falls, River Falls, WI, United StatesBSPhysical Education
    Ball State University, Muncie, IN, United StatesMAExercise Science
    Karolinska Institute, Solna, , SwedenPHDPhysiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stocks B, Zierath JR. Post-translational Modifications: The Signals at the Intersection of Exercise, Glucose Uptake, and Insulin Sensitivity. Endocr Rev. 2022 Jul 13; 43(4):654-677. PMID: 34730177.
      Citations: 1     Fields:    Translation:HumansCells
    2. Dollet L, Kuefner M, Caria E, Rizo-Roca D, Pendergrast L, Abdelmoez AM, Karlsson HKR, Björnholm M, Dalbram E, Treebak JT, Harada J, Näslund E, Rydén M, Zierath JR, Pillon NJ, Krook A. Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes. Diabetes. 2022 04 01; 71(4):624-636. PMID: 35040927.
      Citations:    Fields:    Translation:HumansAnimals
    3. Maqdasy S, Lecoutre S, Renzi G, Frendo-Cumbo S, Rizo-Roca D, Moritz T, Juvany M, Hodek O, Gao H, Couchet M, Witting M, Kerr A, Bergo MO, Choudhury RP, Aouadi M, Zierath JR, Krook A, Mejhert N, Rydén M. Impaired phosphocreatine metabolism in white adipocytes promotes inflammation. Nat Metab. 2022 02; 4(2):190-202. PMID: 35165448.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Stocks B, Gonzalez-Franquesa A, Borg ML, Björnholm M, Niu L, Zierath JR, Deshmukh AS. Integrated Liver and Plasma Proteomics in Obese Mice Reveals Complex Metabolic Regulation. Mol Cell Proteomics. 2022 03; 21(3):100207. PMID: 35093608.
      Citations: 1     Fields:    Translation:Animals
    5. Chibalin AV, Leng Y, Vieira E, Krook A, Björnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nylén C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR. Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance. Cell. 2022 Jan 20; 185(2):397-398. PMID: 35063076.
      Citations:    Fields:    
    6. Sato S, Dyar KA, Treebak JT, Jepsen SL, Ehrlich AM, Ashcroft SP, Trost K, Kunzke T, Prade VM, Small L, Basse AL, Schönke M, Chen S, Samad M, Baldi P, Barrès R, Walch A, Moritz T, Holst JJ, Lutter D, Zierath JR, Sassone-Corsi P. Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis. Cell Metab. 2022 02 01; 34(2):329-345.e8. PMID: 35030324.
      Citations: 6     Fields:    Translation:Animals
    7. Small L, Ehrlich A, Iversen J, Ashcroft SP, Trošt K, Moritz T, Hartmann B, Holst JJ, Treebak JT, Zierath JR, Barrès R. Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice. Mol Metab. 2022 03; 57:101440. PMID: 35026435.
      Citations: 3     Fields:    Translation:HumansAnimals
    8. Gabriel BM, Alt?nta? A, Smith JAB, Sardon-Puig L, Zhang X, Basse AL, Laker RC, Gao H, Liu Z, Dollet L, Treebak JT, Zorzano A, Huo Z, Rydén M, Lanner JT, Esser KA, Barrès R, Pillon NJ, Krook A, Zierath JR. Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle. Sci Adv. 2021 Oct 22; 7(43):eabi9654. PMID: 34669477.
      Citations:    Fields:    
    9. Massart J, Sjögren RJO, Egan B, Garde C, Lindgren M, Gu W, Ferreira DMS, Katayama M, Ruas JL, Barrès R, O'Gorman DJ, Zierath JR, Krook A. Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism. Nat Commun. 2021 10 12; 12(1):5948. PMID: 34642330.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    10. Gonzalez-Franquesa A, Stocks B, Borg ML, Kuefner M, Dalbram E, Nielsen TS, Agrawal A, Pankratova S, Chibalin AV, Karlsson HKR, Gheibi S, Björnholm M, Jørgensen NR, Clemmensen C, Hostrup M, Treebak JT, Krook A, Zierath JR, Deshmukh AS. Discovery of thymosin ?4 as a human exerkine and growth factor. Am J Physiol Cell Physiol. 2021 11 01; 321(5):C770-C778. PMID: 34495765.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    11. Gonzalez-Franquesa A, Peijs L, Cervone DT, Koçana C, Zierath JR, Deshmukh AS. Insulin and 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome. Proteomes. 2021 08 03; 9(3). PMID: 34449730.
      Citations:    
    12. Borg ML, Massart J, De Castro Barbosa T, Archilla-Ortega A, Smith JAB, Lanner JT, Alsina-Fernandez J, Yaden B, Culver AE, Karlsson HKR, Brozinick JT, Zierath JR. Modified UCN2 peptide treatment improves skeletal muscle mass and function in mouse models of obesity-induced insulin resistance. J Cachexia Sarcopenia Muscle. 2021 10; 12(5):1232-1248. PMID: 34342159.
      Citations: 3     Fields:    Translation:Animals
    13. Smith JAB, Savikj M, Sethi P, Platt S, Gabriel BM, Hawley JA, Dunstan D, Krook A, Zierath JR, Näslund E. Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity. Am J Physiol Endocrinol Metab. 2021 08 01; 321(2):E203-E216. PMID: 34151582.
      Citations: 1     Fields:    Translation:Humans
    14. Sjögren RJO, Rizo-Roca D, Chibalin AV, Chorell E, Furrer R, Katayama S, Harada J, Karlsson HKR, Handschin C, Moritz T, Krook A, Näslund E, Zierath JR. Branched-chain amino acid metabolism is regulated by ERR? in primary human myotubes and is further impaired by glucose loading in type 2 diabetes. Diabetologia. 2021 09; 64(9):2077-2091. PMID: 34131782.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    15. Gonzalez-Franquesa A, Stocks B, Chubanava S, Hattel HB, Moreno-Justicia R, Peijs L, Treebak JT, Zierath JR, Deshmukh AS. Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity. Cell Rep. 2021 05 25; 35(8):109180. PMID: 34038727.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    16. Pillon NJ, Loos RJF, Marshall SM, Zierath JR. Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care. Cell. 2021 03 18; 184(6):1530-1544. PMID: 33675692.
      Citations: 28     Fields:    Translation:HumansCellsPHPublic Health
    17. Maasar MF, Turner DC, Gorski PP, Seaborne RA, Strauss JA, Shepherd SO, Cocks M, Pillon NJ, Zierath JR, Hulton AT, Drust B, Sharples AP. The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle. Front Physiol. 2021; 12:619447. PMID: 33679435.
      Citations:    
    18. Karlsson HKR, Kasahara A, Ikeda M, Chibalin AV, Harada J, Rydén M, Krook A, Kato M, Kubota K, Zierath JR. Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study. Metabolism. 2021 05; 118:154726. PMID: 33581131.
      Citations: 1     Fields:    Translation:HumansCells
    19. Lundell LS, Parr EB, Devlin BL, Ingerslev LR, Alt?nta? A, Sato S, Sassone-Corsi P, Barrès R, Zierath JR, Hawley JA. Author Correction: Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression. Nat Commun. 2020 Oct 08; 11(1):5142. PMID: 33033267.
      Citations: 1     Fields:    
    20. Small L, Alt?nta? A, Laker RC, Ehrlich A, Pattamaprapanont P, Villarroel J, Pillon NJ, Zierath JR, Barrès R. Contraction influences Per2 gene expression in skeletal muscle through a calcium-dependent pathway. J Physiol. 2020 12; 598(24):5739-5752. PMID: 32939754.
      Citations: 4     Fields:    Translation:Animals
    21. Lundell LS, Parr EB, Devlin BL, Ingerslev LR, Alt?nta? A, Sato S, Sassone-Corsi P, Barrès R, Zierath JR, Hawley JA. Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression. Nat Commun. 2020 09 16; 11(1):4643. PMID: 32938935.
      Citations: 16     Fields:    Translation:Humans
    22. Batista TM, Jayavelu AK, Wewer Albrechtsen NJ, Iovino S, Lebastchi J, Pan H, Dreyfuss JM, Krook A, Zierath JR, Mann M, Kahn CR. A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes. Cell Metab. 2020 11 03; 32(5):844-859.e5. PMID: 32888406.
      Citations: 20     Fields:    Translation:HumansCells
    23. Hawley JA, Sassone-Corsi P, Zierath JR. Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men. Diabetologia. 2020 11; 63(11):2253-2259. PMID: 32761356.
      Citations: 19     Fields:    Translation:HumansAnimals
    24. Savikj M, Zierath JR. Train like an athlete: applying exercise interventions to manage type 2 diabetes. Diabetologia. 2020 08; 63(8):1491-1499. PMID: 32529411.
      Citations: 11     Fields:    Translation:Humans
    25. Pillon NJ, Gabriel BM, Dollet L, Smith JAB, Sardón Puig L, Botella J, Bishop DJ, Krook A, Zierath JR. Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity. Nat Commun. 2020 01 24; 11(1):470. PMID: 31980607.
      Citations: 75     Fields:    Translation:Humans
    26. Abdelmoez AM, Sardón Puig L, Smith JAB, Gabriel BM, Savikj M, Dollet L, Chibalin AV, Krook A, Zierath JR, Pillon NJ. Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism. Am J Physiol Cell Physiol. 2020 03 01; 318(3):C615-C626. PMID: 31825657.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    27. Zierath JR. Major Advances and Discoveries in Diabetes - 2019 in Review. Curr Diab Rep. 2019 11 04; 19(11):118. PMID: 31686269.
      Citations: 2     Fields:    Translation:Humans
    28. Sardon Puig L, Pillon NJ, Näslund E, Krook A, Zierath JR. Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression. Am J Physiol Endocrinol Metab. 2020 01 01; 318(1):E1-E10. PMID: 31613643.
      Citations: 7     Fields:    Translation:HumansCells
    29. Hochreuter MY, Alt?nta? A, Garde C, Emanuelli B, Kahn CR, Zierath JR, Vienberg S, Barrès R. Identification of two microRNA nodes as potential cooperative modulators of liver metabolism. Hepatol Res. 2019 Dec; 49(12):1451-1465. PMID: 31408567.
      Citations:    
    30. Massart J, Zierath JR. Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis. Trends Endocrinol Metab. 2019 09; 30(9):603-617. PMID: 31331711.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    31. Borg ML, Massart J, Schönke M, De Castro Barbosa T, Guo L, Wade M, Alsina-Fernandez J, Miles R, Ryan A, Bauer S, Coskun T, O'Farrell E, Niemeier EM, Chibalin AV, Krook A, Karlsson HK, Brozinick JT, Zierath JR. Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice. Diabetes. 2019 07; 68(7):1403-1414. PMID: 31010957.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    32. Sato S, Basse AL, Schönke M, Chen S, Samad M, Alt?nta? A, Laker RC, Dalbram E, Barrès R, Baldi P, Treebak JT, Zierath JR, Sassone-Corsi P. Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis. Cell Metab. 2019 07 02; 30(1):92-110.e4. PMID: 31006592.
      Citations: 62     Fields:    Translation:AnimalsCells
    33. Gabriel BM, Zierath JR. Circadian rhythms and exercise - re-setting the clock in metabolic disease. Nat Rev Endocrinol. 2019 04; 15(4):197-206. PMID: 30655625.
      Citations: 58     Fields:    Translation:Humans
    34. Lundström P, Caidahl K, Eriksson MJ, Fritz T, Krook A, Zierath JR, Rickenlund A. Changes in Vitamin D Status in Overweight Middle-Aged Adults with or without Impaired Glucose Metabolism in Two Consecutive Nordic Summers. J Nutr Metab. 2019; 2019:1840374. PMID: 30944737.
      Citations:    
    35. de Castro Barbosa T, Alm PS, Krook A, Barrès R, Zierath JR. Paternal high-fat diet transgenerationally impacts hepatic immunometabolism. FASEB J. 2019 05; 33(5):6269-6280. PMID: 30768368.
      Citations: 6     Fields:    Translation:AnimalsCells
    36. Dalbram E, Basse AL, Zierath JR, Treebak JT. Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action. J Appl Physiol (1985). 2019 04 01; 126(4):993-1005. PMID: 30730814.
      Citations: 6     Fields:    Translation:Animals
    37. Dollet L, Zierath JR. Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue. J Physiol. 2019 03; 597(6):1439-1450. PMID: 30615204.
      Citations: 10     Fields:    Translation:Humans
    38. Katayama M, Wiklander OPB, Fritz T, Caidahl K, El-Andaloussi S, Zierath JR, Krook A. Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle. Diabetes. 2019 03; 68(3):515-526. PMID: 30552111.
      Citations: 40     Fields:    Translation:HumansCells
    39. Nylén C, Lundell LS, Massart J, Zierath JR, Näslund E. Short-term low-calorie diet remodels skeletal muscle lipid profile and metabolic gene expression in obese adults. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E178-E185. PMID: 30481042.
      Citations: 3     Fields:    Translation:Humans
    40. Lundell LS, Massart J, Alt?nta? A, Krook A, Zierath JR. Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle. Mol Metab. 2019 02; 20:79-88. PMID: 30502001.
      Citations: 14     Fields:    Translation:AnimalsCells
    41. Savikj M, Gabriel BM, Alm PS, Smith J, Caidahl K, Björnholm M, Fritz T, Krook A, Zierath JR, Wallberg-Henriksson H. Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial. Diabetologia. 2019 02; 62(2):233-237. PMID: 30426166.
      Citations: 37     Fields:    Translation:Humans
    42. Basse AL, Dalbram E, Larsson L, Gerhart-Hines Z, Zierath JR, Treebak JT. Skeletal Muscle Insulin Sensitivity Show Circadian Rhythmicity Which Is Independent of Exercise Training Status. Front Physiol. 2018; 9:1198. PMID: 30210362.
      Citations:    
    43. Lassiter DG, Sjögren RJO, Gabriel BM, Krook A, Zierath JR. AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle. Mol Metab. 2018 10; 16:12-23. PMID: 30093355.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    44. Pillon NJ, Frendo-Cumbo S, Jacobson MR, Liu Z, Milligan PL, Hoang Bui H, Zierath JR, Bilan PJ, Brozinick JT, Klip A. Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells. J Lipid Res. 2018 07; 59(7):1148-1163. PMID: 29794037.
      Citations: 4     Fields:    Translation:AnimalsCells
    45. Schönke M, Massart J, Zierath JR. Effects of high-fat diet and AMP-activated protein kinase modulation on the regulation of whole-body lipid metabolism. J Lipid Res. 2018 07; 59(7):1276-1282. PMID: 29739863.
      Citations: 8     Fields:    Translation:Animals
    46. Schönke M, Björnholm M, Chibalin AV, Zierath JR, Deshmukh AS. Proteomics Analysis of Skeletal Muscle from Leptin-Deficient ob/ob Mice Reveals Adaptive Remodeling of Metabolic Characteristics and Fiber Type Composition. Proteomics. 2018 03; 18(5-6):e1700375. PMID: 29350465.
      Citations: 10     Fields:    Translation:AnimalsCells
    47. Nascimento EBM, Mannerås-Holm L, Chibalin AV, Björnholm M, Zierath JR. Diacylglycerol kinase ? deficiency alters inflammation markers in adipose tissue in response to a high-fat diet. J Lipid Res. 2018 02; 59(2):273-282. PMID: 29233919.
      Citations: 5     Fields:    Translation:Animals
    48. Benziane B, Borg ML, Tom RZ, Riedl I, Massart J, Björnholm M, Gilbert M, Chibalin AV, Zierath JR. DGK? deficiency protects against peripheral insulin resistance and improves energy metabolism. J Lipid Res. 2017 12; 58(12):2324-2333. PMID: 29066466.
      Citations: 5     Fields:    Translation:Animals
    49. Lassiter DG, Nylén C, Sjögren RJO, Chibalin AV, Wallberg-Henriksson H, Näslund E, Krook A, Zierath JR. FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle. Diabetologia. 2018 02; 61(2):424-432. PMID: 29022062.
      Citations: 10     Fields:    Translation:HumansCells
    50. Ruby MA, Riedl I, Massart J, Åhlin M, Zierath JR. Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle. Am J Physiol Endocrinol Metab. 2017 10 01; 313(4):E483-E491. PMID: 28720584.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    51. Alm PS, de Castro Barbosa T, Barrès R, Krook A, Zierath JR. Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle. Mol Metab. 2017 07; 6(7):621-630. PMID: 28702319.
      Citations: 4     Fields:    Translation:AnimalsCells
    52. Gabriel BM, Zierath JR. The Limits of Exercise Physiology: From Performance to Health. Cell Metab. 2017 May 02; 25(5):1000-1011. PMID: 28467920.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    53. Massart J, Sjögren RJO, Lundell LS, Mudry JM, Franck N, O'Gorman DJ, Egan B, Zierath JR, Krook A. Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle. Diabetes. 2017 07; 66(7):1807-1818. PMID: 28404597.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    54. Mannerås-Holm L, Schönke M, Brozinick JT, Vetterli L, Bui HH, Sanders P, Nascimento EBM, Björnholm M, Chibalin AV, Zierath JR. Diacylglycerol kinase ? deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice. J Lipid Res. 2017 05; 58(5):907-915. PMID: 28246337.
      Citations: 8     Fields:    Translation:AnimalsCells
    55. Ruby MA, Massart J, Hunerdosse DM, Schönke M, Correia JC, Louie SM, Ruas JL, Näslund E, Nomura DK, Zierath JR. Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance. Cell Rep. 2017 01 17; 18(3):636-646. PMID: 28099843.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    56. Mudry JM, Lassiter DG, Nylén C, García-Calzón S, Näslund E, Krook A, Zierath JR. Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle. Diabetes. 2017 03; 66(3):651-662. PMID: 28011458.
      Citations: 16     Fields:    Translation:HumansCells
    57. Zierath JR. Building Bridges through Scientific Conferences. Cell. 2016 Nov 17; 167(5):1155-1158. PMID: 27863234.
      Citations: 3     Fields:    
    58. Kjøbsted R, Munk-Hansen N, Birk JB, Foretz M, Viollet B, Björnholm M, Zierath JR, Treebak JT, Wojtaszewski JF. Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK. Diabetes. 2017 03; 66(3):598-612. PMID: 27797909.
      Citations: 62     Fields:    Translation:AnimalsCells
    59. Egan B, Hawley JA, Zierath JR. SnapShot: Exercise Metabolism. Cell Metab. 2016 08 09; 24(2):342-342.e1. PMID: 27508878.
      Citations: 16     Fields:    Translation:HumansCells
    60. Cartee GD, Hepple RT, Bamman MM, Zierath JR. Exercise Promotes Healthy Aging of Skeletal Muscle. Cell Metab. 2016 06 14; 23(6):1034-1047. PMID: 27304505.
      Citations: 149     Fields:    Translation:HumansCells
    61. Mudry JM, Alm PS, Erhardt S, Goiny M, Fritz T, Caidahl K, Zierath JR, Krook A, Wallberg-Henriksson H. Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes. Diabetes Metab Res Rev. 2016 10; 32(7):754-761. PMID: 26946084.
      Citations: 18     Fields:    Translation:Humans
    62. Riedl I, Osler ME, Björnholm M, Egan B, Nader GA, Chibalin AV, Zierath JR. AMPK?3 is dispensable for skeletal muscle hypertrophy induced by functional overload. Am J Physiol Endocrinol Metab. 2016 Mar 15; 310(6):E461-72. PMID: 26758685.
      Citations: 2     Fields:    Translation:AnimalsCells
    63. Kirchner H, Sinha I, Gao H, Ruby MA, Schönke M, Lindvall JM, Barrès R, Krook A, Näslund E, Dahlman-Wright K, Zierath JR. Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients. Mol Metab. 2016 Mar; 5(3):171-183. PMID: 26977391.
      Citations: 43     Fields:    
    64. Donkin I, Versteyhe S, Ingerslev LR, Qian K, Mechta M, Nordkap L, Mortensen B, Appel EV, Jørgensen N, Kristiansen VB, Hansen T, Workman CT, Zierath JR, Barrès R. Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans. Cell Metab. 2016 Feb 09; 23(2):369-78. PMID: 26669700.
      Citations: 175     Fields:    Translation:HumansCells
    65. Zierath JR. Erratum to: Turning the page. Diabetologia. 2015 Dec; 58(12):2899. PMID: 26471902.
      Citations:    Fields:    
    66. Zierath JR. Turning the page. Diabetologia. 2015 Dec; 58(12):2685-7. PMID: 26407714.
      Citations:    Fields:    Translation:Humans
    67. Boon H, Sjögren RJ, Massart J, Egan B, Kostovski E, Iversen PO, Hjeltnes N, Chibalin AV, Widegren U, Zierath JR. MicroRNA-208b progressively declines after spinal cord injury in humans and is inversely related to myostatin expression. Physiol Rep. 2015 Nov; 3(11). PMID: 26603456.
      Citations: 6     Fields:    
    68. Jiang LQ, de Castro Barbosa T, Massart J, Deshmukh AS, Löfgren L, Duque-Guimaraes DE, Ozilgen A, Osler ME, Chibalin AV, Zierath JR. Diacylglycerol kinase-? regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics. Am J Physiol Endocrinol Metab. 2016 Jan 01; 310(1):E51-60. PMID: 26530149.
      Citations: 11     Fields:    Translation:AnimalsCells
    69. Correia JC, Massart J, de Boer JF, Porsmyr-Palmertz M, Martínez-Redondo V, Agudelo LZ, Sinha I, Meierhofer D, Ribeiro V, Björnholm M, Sauer S, Dahlman-Wright K, Zierath JR, Groen AK, Ruas JL. Bioenergetic cues shift FXR splicing towards FXR?2 to modulate hepatic lipolysis and fatty acid metabolism. Mol Metab. 2015 Dec; 4(12):891-902. PMID: 26909306.
      Citations: 12     Fields:    
    70. Schönke M, Myers MG, Zierath JR, Björnholm M. Skeletal muscle AMP-activated protein kinase ?1(H151R) overexpression enhances whole body energy homeostasis and insulin sensitivity. Am J Physiol Endocrinol Metab. 2015 Oct 01; 309(7):E679-90. PMID: 26306597.
      Citations: 7     Fields:    Translation:AnimalsCells
    71. Zierath JR. Diabetologia at 50: celebrating half a century of progress in diabetes research and care. Diabetologia. 2015 Aug; 58(8):1685-7. PMID: 26013681.
      Citations:    Fields:    Translation:HumansAnimals
    72. Cedernaes J, Osler ME, Voisin S, Broman JE, Vogel H, Dickson SL, Zierath JR, Schiöth HB, Benedict C. Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men. J Clin Endocrinol Metab. 2015 Sep; 100(9):E1255-61. PMID: 26168277.
      Citations: 56     Fields:    Translation:Humans
    73. Zierath JR, Wallberg-Henriksson H. Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us? Cell Metab. 2015 Jul 07; 22(1):25-30. PMID: 26154051.
      Citations: 30     Fields:    Translation:HumansAnimals
    74. Ring M, Eriksson MJ, Fritz T, Nyberg G, Östenson CG, Krook A, Zierath JR, Caidahl K. Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance. Diab Vasc Dis Res. 2015 Sep; 12(5):315-24. PMID: 26092821.
      Citations: 7     Fields:    Translation:Humans
    75. Mannerås-Holm L, Kirchner H, Björnholm M, Chibalin AV, Zierath JR. mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance. Physiol Rep. 2015 Apr; 3(4). PMID: 25847921.
      Citations: 12     Fields:    
    76. Osler ME, Fritz T, Caidahl K, Krook A, Zierath JR, Wallberg-Henriksson H. Changes in gene expression in responders and nonresponders to a low-intensity walking intervention. Diabetes Care. 2015 Jun; 38(6):1154-60. PMID: 25795414.
      Citations: 13     Fields:    Translation:HumansCells
    77. Riedl I, Osler ME, Benziane B, Chibalin AV, Zierath JR. Association of the ACTN3 R577X polymorphism with glucose tolerance and gene expression of sarcomeric proteins in human skeletal muscle. Physiol Rep. 2015 Mar; 3(3). PMID: 25780092.
      Citations: 11     Fields:    
    78. Wallberg-Henriksson H, Zierath JR. Metabolism. Exercise remodels subcutaneous fat tissue and improves metabolism. Nat Rev Endocrinol. 2015 Apr; 11(4):198-200. PMID: 25707778.
      Citations: 9     Fields:    Translation:Animals
    79. Multhaup ML, Seldin MM, Jaffe AE, Lei X, Kirchner H, Mondal P, Li Y, Rodriguez V, Drong A, Hussain M, Lindgren C, McCarthy M, Näslund E, Zierath JR, Wong GW, Feinberg AP. Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metab. 2015 Jan 06; 21(1):138-49. PMID: 25565211.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    80. Sjögren RJ, Egan B, Katayama M, Zierath JR, Krook A. Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells. Physiol Genomics. 2015 Mar; 47(3):45-57. PMID: 25547110.
      Citations: 8     Fields:    Translation:HumansCells
    81. Hawley JA, Hargreaves M, Joyner MJ, Zierath JR. Integrative biology of exercise. Cell. 2014 Nov 06; 159(4):738-49. PMID: 25417152.
      Citations: 296     Fields:    Translation:HumansAnimals
    82. Pirkmajer S, Kulkarni SS, Tom RZ, Ross FA, Hawley SA, Hardie DG, Zierath JR, Chibalin AV. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation. Diabetes. 2015 Feb; 64(2):360-9. PMID: 25338814.
      Citations: 36     Fields:    Translation:HumansCells
    83. Agudelo LZ, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DMS, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL. Skeletal muscle PGC-1?1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell. 2014 Sep 25; 159(1):33-45. PMID: 25259918.
      Citations: 220     Fields:    Translation:HumansAnimalsCells
    84. Al-Khalili L, de Castro Barbosa T, Ostling J, Massart J, Cuesta PG, Osler ME, Katayama M, Nyström AC, Oscarsson J, Zierath JR. Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes. Am J Physiol Cell Physiol. 2014 Nov 01; 307(9):C774-87. PMID: 25143351.
      Citations: 13     Fields:    Translation:HumansCells
    85. Ring M, Eriksson MJ, Zierath JR, Caidahl K. Arterial stiffness estimation in healthy subjects: a validation of oscillometric (Arteriograph) and tonometric (SphygmoCor) techniques. Hypertens Res. 2014 Nov; 37(11):999-1007. PMID: 25056681.
      Citations: 40     Fields:    Translation:Humans
    86. Moltke I, Grarup N, Jørgensen ME, Bjerregaard P, Treebak JT, Fumagalli M, Korneliussen TS, Andersen MA, Nielsen TS, Krarup NT, Gjesing AP, Zierath JR, Linneberg A, Wu X, Sun G, Jin X, Al-Aama J, Wang J, Borch-Johnsen K, Pedersen O, Nielsen R, Albrechtsen A, Hansen T. A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes. Nature. 2014 Aug 14; 512(7513):190-3. PMID: 25043022.
      Citations: 155     Fields:    Translation:Humans
    87. Rasmussen M, Zierath JR, Barrès R. Dynamic epigenetic responses to muscle contraction. Drug Discov Today. 2014 Jul; 19(7):1010-4. PMID: 24631681.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    88. Zachariah Tom R, Garcia-Roves PM, Sjögren RJ, Jiang LQ, Holmström MH, Deshmukh AS, Vieira E, Chibalin AV, Björnholm M, Zierath JR. Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice. Diabetes. 2014 May; 63(5):1560-71. PMID: 24487023.
      Citations: 12     Fields:    Translation:AnimalsCells
    89. Kirchner H, Nylen C, Laber S, Barrès R, Yan J, Krook A, Zierath JR, Näslund E. Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass. Surg Obes Relat Dis. 2014 Jul-Aug; 10(4):671-8. PMID: 24837562.
      Citations: 31     Fields:    Translation:HumansCells
    90. Nascimento EB, Osler ME, Zierath JR. Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle. Am J Physiol Endocrinol Metab. 2013 Dec 01; 305(11):E1408-14. PMID: 24129397.
      Citations: 14     Fields:    Translation:HumansCells
    91. Jiang LQ, Franck N, Egan B, Sjögren RJ, Katayama M, Duque-Guimaraes D, Arner P, Zierath JR, Krook A. Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7. Am J Physiol Endocrinol Metab. 2013 Dec 01; 305(11):E1359-66. PMID: 24105413.
      Citations: 52     Fields:    Translation:HumansCells
    92. Egan B, O'Connor PL, Zierath JR, O'Gorman DJ. Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle. PLoS One. 2013; 8(9):e74098. PMID: 24069271.
      Citations: 48     Fields:    Translation:HumansCells
    93. Brandauer J, Vienberg SG, Andersen MA, Ringholm S, Risis S, Larsen PS, Kristensen JM, Frøsig C, Leick L, Fentz J, Jørgensen S, Kiens B, Wojtaszewski JF, Richter EA, Zierath JR, Goodyear LJ, Pilegaard H, Treebak JT. AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle. J Physiol. 2013 Oct 15; 591(20):5207-20. PMID: 23918774.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    94. Dokas J, Chadt A, Nolden T, Himmelbauer H, Zierath JR, Joost HG, Al-Hasani H. Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle. Endocrinology. 2013 Oct; 154(10):3502-14. PMID: 23892475.
      Citations: 31     Fields:    Translation:Animals
    95. Cansby E, Amrutkar M, Mannerås Holm L, Nerstedt A, Reyahi A, Stenfeldt E, Borén J, Carlsson P, Smith U, Zierath JR, Mahlapuu M. Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet. FASEB J. 2013 Sep; 27(9):3660-71. PMID: 23729594.
      Citations: 16     Fields:    Translation:AnimalsCells
    96. Holmström MH, Tom RZ, Björnholm M, Garcia-Roves PM, Zierath JR. Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice. Metabolism. 2013 Sep; 62(9):1258-67. PMID: 23664724.
      Citations: 11     Fields:    Translation:AnimalsCells
    97. Barres R, Kirchner H, Rasmussen M, Yan J, Kantor FR, Krook A, Näslund E, Zierath JR. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep. 2013 Apr 25; 3(4):1020-7. PMID: 23583180.
      Citations: 116     Fields:    Translation:HumansCells
    98. Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013 Feb 05; 17(2):162-84. PMID: 23395166.
      Citations: 622     Fields:    Translation:HumansCells
    99. Jiang LQ, Duque-Guimaraes DE, Machado UF, Zierath JR, Krook A. Altered response of skeletal muscle to IL-6 in type 2 diabetic patients. Diabetes. 2013 Feb; 62(2):355-61. PMID: 23086036.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    100. Mashili F, Chibalin AV, Krook A, Zierath JR. Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes. 2013 Feb; 62(2):457-65. PMID: 23043161.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    101. Szekeres F, Chadt A, Tom RZ, Deshmukh AS, Chibalin AV, Björnholm M, Al-Hasani H, Zierath JR. The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism. Am J Physiol Endocrinol Metab. 2012 Aug 15; 303(4):E524-33. PMID: 22693207.
      Citations: 39     Fields:    Translation:AnimalsCells
    102. Benziane B, Björnholm M, Pirkmajer S, Austin RL, Kotova O, Viollet B, Zierath JR, Chibalin AV. Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells. J Biol Chem. 2012 Jul 06; 287(28):23451-63. PMID: 22610379.
      Citations: 25     Fields:    Translation:AnimalsCells
    103. Barrès R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, O'Gorman DJ, Zierath JR. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012 Mar 07; 15(3):405-11. PMID: 22405075.
      Citations: 308     Fields:    Translation:HumansAnimalsCells
    104. Holmström MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM. Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab. 2012 Mar 15; 302(6):E731-9. PMID: 22252943.
      Citations: 59     Fields:    Translation:AnimalsCells
    105. Yan J, Zierath JR, Barrès R. Evidence for non-CpG methylation in mammals. Exp Cell Res. 2011 Nov 01; 317(18):2555-61. PMID: 21925168.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    106. Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR. Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. J Biol Chem. 2011 Oct 07; 286(40):34567-74. PMID: 21873433.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    107. Kulkarni SS, Salehzadeh F, Fritz T, Zierath JR, Krook A, Osler ME. Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus. Metabolism. 2012 Feb; 61(2):175-85. PMID: 21816445.
      Citations: 42     Fields:    Translation:HumansCells
    108. Zierath JR, Barrès RE. Nutritional status affects the epigenomic profile of peripheral blood cells. Epigenomics. 2011 Jun; 3(3):259-60. PMID: 22122335.
      Citations: 2     Fields:    
    109. Mashili FL, Austin RL, Deshmukh AS, Fritz T, Caidahl K, Bergdahl K, Zierath JR, Chibalin AV, Moller DE, Kharitonenkov A, Krook A. Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity. Diabetes Metab Res Rev. 2011 Mar; 27(3):286-97. PMID: 21309058.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    110. Feng X, Yan J, Wang Y, Zierath JR, Nordenskjöld M, Henter JI, Fadeel B, Zheng C. The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells. Mol Immunol. 2010 Aug; 47(14):2388-96. PMID: 20542572.
      Citations: 24     Fields:    Translation:HumansCells
    111. Sogaard P, Szekeres F, Garcia-Roves PM, Larsson D, Chibalin AV, Zierath JR. Spatial insulin signalling in isolated skeletal muscle preparations. J Cell Biochem. 2010 Apr 01; 109(5):943-9. PMID: 20069552.
      Citations: 1     Fields:    Translation:AnimalsCells
    112. Cantó C, Jiang LQ, Deshmukh AS, Mataki C, Coste A, Lagouge M, Zierath JR, Auwerx J. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 2010 Mar 03; 11(3):213-9. PMID: 20197054.
      Citations: 360     Fields:    Translation:AnimalsCells
    113. Jiang LQ, Garcia-Roves PM, de Castro Barbosa T, Zierath JR. Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity. Am J Physiol Endocrinol Metab. 2010 Jan; 298(1):E8-E16. PMID: 19861587.
      Citations: 25     Fields:    Translation:AnimalsCells
    114. Benziane B, Björnholm M, Lantier L, Viollet B, Zierath JR, Chibalin AV. AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase. Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1554-66. PMID: 19828836.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    115. Deshmukh AS, Glund S, Tom RZ, Zierath JR. Role of the AMPKgamma3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscle. Am J Physiol Endocrinol Metab. 2009 Dec; 297(6):E1388-94. PMID: 19826102.
      Citations: 5     Fields:    Translation:AnimalsCells
    116. Barrès R, Osler ME, Yan J, Rune A, Fritz T, Caidahl K, Krook A, Zierath JR. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab. 2009 Sep; 10(3):189-98. PMID: 19723495.
      Citations: 246     Fields:    Translation:HumansCells
    117. Wallberg-Henriksson H, Zierath JR. A new twist on brown fat metabolism. Cell. 2009 Apr 03; 137(1):22-4. PMID: 19345181.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    118. Sultan A, Strodthoff D, Robertson AK, Paulsson-Berne G, Fauconnier J, Parini P, Rydén M, Thierry-Mieg N, Johansson ME, Chibalin AV, Zierath JR, Arner P, Hansson GK. T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice. Circ Res. 2009 Apr 24; 104(8):961-8. PMID: 19299644.
      Citations: 24     Fields:    Translation:AnimalsCells
    119. Karlsson HK, Chibalin AV, Koistinen HA, Yang J, Koumanov F, Wallberg-Henriksson H, Zierath JR, Holman GD. Kinetics of GLUT4 trafficking in rat and human skeletal muscle. Diabetes. 2009 Apr; 58(4):847-54. PMID: 19188436.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    120. Benziane B, Burton TJ, Scanlan B, Galuska D, Canny BJ, Chibalin AV, Zierath JR, Stepto NK. Divergent cell signaling after short-term intensified endurance training in human skeletal muscle. Am J Physiol Endocrinol Metab. 2008 Dec; 295(6):E1427-38. PMID: 18827172.
      Citations: 31     Fields:    Translation:HumansCellsCTClinical Trials
    121. Glund S, Treebak JT, Long YC, Barres R, Viollet B, Wojtaszewski JF, Zierath JR. Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle. Endocrinology. 2009 Feb; 150(2):600-6. PMID: 18818284.
      Citations: 17     Fields:    Translation:AnimalsCells
    122. Vieira E, Nilsson EC, Nerstedt A, Ormestad M, Long YC, Garcia-Roves PM, Zierath JR, Mahlapuu M. Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle. Am J Physiol Endocrinol Metab. 2008 Nov; 295(5):E1032-7. PMID: 18728219.
      Citations: 31     Fields:    Translation:Animals
    123. Cabrera O, Jacques-Silva MC, Speier S, Yang SN, Köhler M, Fachado A, Vieira E, Zierath JR, Kibbey R, Berman DM, Kenyon NS, Ricordi C, Caicedo A, Berggren PO. Glutamate is a positive autocrine signal for glucagon release. Cell Metab. 2008 Jun; 7(6):545-54. PMID: 18522835.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    124. Austin RL, Rune A, Bouzakri K, Zierath JR, Krook A. siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. Diabetes. 2008 Aug; 57(8):2066-73. PMID: 18443205.
      Citations: 31     Fields:    Translation:HumansCells
    125. Bouzakri K, Austin R, Rune A, Lassman ME, Garcia-Roves PM, Berger JP, Krook A, Chibalin AV, Zhang BB, Zierath JR. Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes. 2008 Jun; 57(6):1508-16. PMID: 18314420.
      Citations: 34     Fields:    Translation:HumansCells
    126. Deshmukh AS, Treebak JT, Long YC, Viollet B, Wojtaszewski JF, Zierath JR. Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling. Mol Endocrinol. 2008 May; 22(5):1105-12. PMID: 18276828.
      Citations: 16     Fields:    Translation:AnimalsCells
    127. Chibalin AV, Leng Y, Vieira E, Krook A, Björnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nylén C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR. Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell. 2008 Feb 08; 132(3):375-86. PMID: 18267070.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    128. Glund S, Deshmukh A, Long YC, Moller T, Koistinen HA, Caidahl K, Zierath JR, Krook A. Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle. Diabetes. 2007 Jun; 56(6):1630-7. PMID: 17363741.
      Citations: 64     Fields:    Translation:HumansCells
    129. Zierath JR. The path to insulin resistance: paved with ceramides? Cell Metab. 2007 Mar; 5(3):161-3. PMID: 17339023.
      Citations: 19     Fields:    Translation:HumansAnimals
    130. Bouzakri K, Zierath JR. MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. J Biol Chem. 2007 Mar 16; 282(11):7783-9. PMID: 17227768.
      Citations: 60     Fields:    Translation:HumansCells
    131. Karlsson HK, Zierath JR. Insulin signaling and glucose transport in insulin resistant human skeletal muscle. Cell Biochem Biophys. 2007; 48(2-3):103-13. PMID: 17709880.
      Citations: 55     Fields:    Translation:HumansCells
    132. Fritz T, Krämer DK, Karlsson HK, Galuska D, Engfeldt P, Zierath JR, Krook A. Low-intensity exercise increases skeletal muscle protein expression of PPARdelta and UCP3 in type 2 diabetic patients. Diabetes Metab Res Rev. 2006 Nov-Dec; 22(6):492-8. PMID: 16752430.
      Citations: 39     Fields:    Translation:Humans
    133. Long YC, Zierath JR. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest. 2006 Jul; 116(7):1776-83. PMID: 16823475.
      Citations: 293     Fields:    Translation:HumansCells
    134. Bouzakri K, Zachrisson A, Al-Khalili L, Zhang BB, Koistinen HA, Krook A, Zierath JR. siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 2006 Jul; 4(1):89-96. PMID: 16814735.
      Citations: 77     Fields:    Translation:HumansCells
    135. Deshmukh A, Coffey VG, Zhong Z, Chibalin AV, Hawley JA, Zierath JR. Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle. Diabetes. 2006 Jun; 55(6):1776-82. PMID: 16731842.
      Citations: 46     Fields:    Translation:HumansCellsCTClinical Trials
    136. Karlsson HK, Ahlsén M, Zierath JR, Wallberg-Henriksson H, Koistinen HA. Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients. Diabetes. 2006 May; 55(5):1283-8. PMID: 16644684.
      Citations: 28     Fields:    Translation:HumansCells
    137. Bouzakri K, Karlsson HK, Vestergaard H, Madsbad S, Christiansen E, Zierath JR. IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients. Diabetes. 2006 Mar; 55(3):785-91. PMID: 16505244.
      Citations: 21     Fields:    Translation:HumansCells
    138. Kannisto K, Chibalin A, Glinghammar B, Zierath JR, Hamsten A, Ehrenborg E. Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise. Int J Mol Med. 2006 Jan; 17(1):45-52. PMID: 16328010.
      Citations: 16     Fields:    Translation:Animals
    139. Bach D, Naon D, Pich S, Soriano FX, Vega N, Rieusset J, Laville M, Guillet C, Boirie Y, Wallberg-Henriksson H, Manco M, Calvani M, Castagneto M, Palacín M, Mingrone G, Zierath JR, Vidal H, Zorzano A. Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. Diabetes. 2005 Sep; 54(9):2685-93. PMID: 16123358.
      Citations: 150     Fields:    Translation:Humans
    140. Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H. Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes. 2005 Jun; 54(6):1692-7. PMID: 15919790.
      Citations: 104     Fields:    Translation:HumansCells
    141. Karlsson HK, Hällsten K, Björnholm M, Tsuchida H, Chibalin AV, Virtanen KA, Heinonen OJ, Lönnqvist F, Nuutila P, Zierath JR. Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study. Diabetes. 2005 May; 54(5):1459-67. PMID: 15855334.
      Citations: 34     Fields:    Translation:HumansCellsCTClinical Trials
    142. Barnes BR, Glund S, Long YC, Hjälm G, Andersson L, Zierath JR. 5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics. FASEB J. 2005 May; 19(7):773-9. PMID: 15857891.
      Citations: 25     Fields:    Translation:AnimalsCells
    143. Bouzakri K, Koistinen HA, Zierath JR. Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes. Curr Diabetes Rev. 2005 May; 1(2):167-74. PMID: 18220592.
      Citations: 35     Fields:    Translation:Humans
    144. Krämer DK, Al-Khalili L, Perrini S, Skogsberg J, Wretenberg P, Kannisto K, Wallberg-Henriksson H, Ehrenborg E, Zierath JR, Krook A. Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta. Diabetes. 2005 Apr; 54(4):1157-63. PMID: 15793256.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    145. Zierath JR. Kinases in diabetes. Part II. 11-12 November 2004, Manchester, UK. IDrugs. 2005 Feb; 8(2):121-3. PMID: 15696413.
      Citations:    Fields:    Translation:HumansAnimals
    146. Zierath JR. Kinases in diabetes. Part I. 11-12 November 2004, Manchester, UK. IDrugs. 2005 Feb; 8(2):118-20. PMID: 15696412.
      Citations:    Fields:    Translation:HumansAnimals
    147. Zierath JR, Hawley JA. Skeletal muscle fiber type: influence on contractile and metabolic properties. PLoS Biol. 2004 Oct; 2(10):e348. PMID: 15486583.
      Citations: 149     Fields:    Translation:HumansAnimalsCells
    148. Barnes BR, Marklund S, Steiler TL, Walter M, Hjälm G, Amarger V, Mahlapuu M, Leng Y, Johansson C, Galuska D, Lindgren K, Abrink M, Stapleton D, Zierath JR, Andersson L. The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J Biol Chem. 2004 Sep 10; 279(37):38441-7. PMID: 15247217.
      Citations: 108     Fields:    Translation:AnimalsCells
    149. Krook A, Wallberg-Henriksson H, Zierath JR. Sending the signal: molecular mechanisms regulating glucose uptake. Med Sci Sports Exerc. 2004 Jul; 36(7):1212-7. PMID: 15235328.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    150. Al-Khalili L, Krook A, Zierath JR, Cartee GD. Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake. Am J Physiol Endocrinol Metab. 2004 Sep; 287(3):E553-7. PMID: 15149951.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    151. Leng Y, Karlsson HK, Zierath JR. Insulin signaling defects in type 2 diabetes. Rev Endocr Metab Disord. 2004 May; 5(2):111-7. PMID: 15041786.
      Citations: 21     Fields:    Translation:HumansCells
    152. Al-Khalili L, Chibalin AV, Yu M, Sjödin B, Nylén C, Zierath JR, Krook A. MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways. Am J Physiol Cell Physiol. 2004 Jun; 286(6):C1410-6. PMID: 14960415.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    153. Perrini S, Henriksson J, Zierath JR, Widegren U. Exercise-induced protein kinase C isoform-specific activation in human skeletal muscle. Diabetes. 2004 Jan; 53(1):21-4. PMID: 14693693.
      Citations: 14     Fields:    Translation:HumansCells
    154. Koistinen HA, Forsgren M, Wallberg-Henriksson H, Zierath JR. Insulin action on expression of novel adipose genes in healthy and type 2 diabetic subjects. Obes Res. 2004 Jan; 12(1):25-31. PMID: 14742839.
      Citations: 6     Fields:    Translation:Humans
    155. Ryder JW, Bassel-Duby R, Olson EN, Zierath JR. Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways. J Biol Chem. 2003 Nov 07; 278(45):44298-304. PMID: 12941959.
      Citations: 50     Fields:    Translation:AnimalsCells
    156. Steiler TL, Galuska D, Leng Y, Chibalin AV, Gilbert M, Zierath JR. Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats. Endocrinology. 2003 Dec; 144(12):5259-67. PMID: 12960081.
      Citations: 13     Fields:    Translation:AnimalsCells
    157. Kemppainen J, Tsuchida H, Stolen K, Karlsson H, Björnholm M, Heinonen OJ, Nuutila P, Krook A, Knuuti J, Zierath JR. Insulin signalling and resistance in patients with chronic heart failure. J Physiol. 2003 Jul 01; 550(Pt 1):305-15. PMID: 12740426.
      Citations: 12     Fields:    Translation:HumansCells
    158. Koistinen HA, Galuska D, Chibalin AV, Yang J, Zierath JR, Holman GD, Wallberg-Henriksson H. 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes. 2003 May; 52(5):1066-72. PMID: 12716734.
      Citations: 71     Fields:    Translation:Humans
    159. Isaksson B, Strömmer L, Friess H, Büchler MW, Herrington MK, Wang F, Zierath JR, Wallberg-Henriksson H, Larsson J, Permert J. Impaired insulin action on phosphatidylinositol 3-kinase activity and glucose transport in skeletal muscle of pancreatic cancer patients. Pancreas. 2003 Mar; 26(2):173-7. PMID: 12604916.
      Citations: 12     Fields:    Translation:Humans
    160. Bach D, Pich S, Soriano FX, Vega N, Baumgartner B, Oriola J, Daugaard JR, Lloberas J, Camps M, Zierath JR, Rabasa-Lhoret R, Wallberg-Henriksson H, Laville M, Palacín M, Vidal H, Rivera F, Brand M, Zorzano A. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem. 2003 May 09; 278(19):17190-7. PMID: 12598526.
      Citations: 322     Fields:    Translation:HumansAnimalsCells
    161. Yu M, Stepto NK, Chibalin AV, Fryer LG, Carling D, Krook A, Hawley JA, Zierath JR. Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise. J Physiol. 2003 Jan 15; 546(Pt 2):327-35. PMID: 12527721.
      Citations: 40     Fields:    Translation:HumansCells
    162. Tsuchida H, Björnholm M, Fernström M, Galuska D, Johansson P, Wallberg-Henriksson H, Zierath JR, Lake S, Krook A. Gene expression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects. Pflugers Arch. 2002 Oct; 445(1):25-31. PMID: 12397383.
      Citations: 3     Fields:    Translation:Humans
    163. Barnes BR, Ryder JW, Steiler TL, Fryer LG, Carling D, Zierath JR. Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction. Diabetes. 2002 Sep; 51(9):2703-8. PMID: 12196462.
      Citations: 16     Fields:    Translation:Animals
    164. Ceddia RB, Koistinen HA, Zierath JR, Sweeney G. Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J. 2002 Aug; 16(10):1163-76. PMID: 12153984.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    165. Zierath JR. Invited review: Exercise training-induced changes in insulin signaling in skeletal muscle. J Appl Physiol (1985). 2002 Aug; 93(2):773-81. PMID: 12133891.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    166. Zierath JR, Wallberg-Henriksson H. From receptor to effector: insulin signal transduction in skeletal muscle from type II diabetic patients. Ann N Y Acad Sci. 2002 Jun; 967:120-34. PMID: 12079842.
      Citations: 20     Fields:    Translation:HumansCells
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