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Yukiko Maeda PhD

TitleInstructor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North, LRB 240D
Worcester MA 01655
Phone508-856-4953
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionRheumatology


    Collapse Biography 
    Collapse education and training
    Ritsumeikan University, Shiga, , JapanBSMathematical Physics
    Nara Institute of Science and Technology, Nara, , JapanMSBiosciences
    Tokyo Medical and Dental University, Tokyo, , JapanPHDMolecular Pharmacology
    Collapse awards and honors
    2003Super Student award, Tokyo Medical and Dental University
    2003Travel Award, International Bone and Mineral Society
    2006Harold M. Frost Young Investigator Award, American Society for Bone and Mineral Research
    2006Young Investigator Award, American Society for Bone and Mineral Research
    2006Dean's Scholars Award, Harvard School of Dental Medicine
    2007Dean's Scholars Award, Harvard School of Dental Medicine
    2016Joseph P. Healey Grants, University of Massachusetts Joseph P. Healey Endowment

    Collapse Overview 
    Collapse overview

    Research Interest

    My focus is applying my expertise in the area of skeletal biology to develop new therapeutic strategies for bone diseases. Autoimmune diseases such as rheumatoid arthritis and ankylosing spondylitis cause various problems to bone, including bone erosion, osteoporosis and ectopic new bone formation, which require new treatment strategies. My study suggested inflamed synovium derived miRNAs regulate bone erosion in rheumatoid arthritis. I am further interested in the role of exosomes, carriers of miRNAs, in bone formation in rheumatoid arthritis. I am also studying the mechanism of entheseal bone formation in ankylosing spondylitis using various inflammatory disease models.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Maeda Y, Farina NH, Matzelle MM, Fanning PJ, Lian JB, Gravallese EM. Synovium-derived microRNAs regulate bone pathways in rheumatoid arthritis. J Bone Miner Res. 2017; 32(3):461-472.
    2. O'Brien W, Fissel BM, Maeda Y, Yan J, Ge X, Gravallese EM, Aliprantis AO, Charles JF. RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis. Arthritis Rheumatol. 2016 Dec; 68(12):2889-2900. PMID: 27563728.
      View in: PubMed
    3. Shaw AT, Maeda Y, Gravallese EM. IL-17A deficiency promotes periosteal bone formation in a model of inflammatory arthritis. Arthritis Res Ther. 2016 May 10; 18(1):104. PMID: 27165410.
      View in: PubMed
    4. Matzelle MM, Shaw AT, Baum R, Maeda Y, Li J, Karmakar S, Manning CA, Walsh NC, Rosen V, Gravallese EM. Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation. Scand J Rheumatol. 2016 Oct; 45(5):379-83. PMID: 26982203.
      View in: PubMed
    5. Hassan MQ, Maeda Y, Taipaleenmaki H, Zhang W, Jafferji M, Gordon JA, Li Z, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells. J Biol Chem. 2012 Dec 7; 287(50):42084-92. PMID: 23060446.
      View in: PubMed
    6. Correa D, Hesse E, Seriwatanachai D, Kiviranta R, Saito H, Yamana K, Neff L, Atfi A, Coillard L, Sitara D, Maeda Y, Warming S, Jenkins NA, Copeland NG, Horne WC, Lanske B, Baron R. Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010 Oct 19; 19(4):533-46. PMID: 20951345.
      View in: PubMed
    7. Ochiai T, Shibukawa Y, Nagayama M, Mundy C, Yasuda T, Okabe T, Shimono K, Kanyama M, Hasegawa H, Maeda Y, Lanske B, Pacifici M, Koyama E. Indian hedgehog roles in post-natal TMJ development and organization. J Dent Res. 2010 Apr; 89(4):349-54. PMID: 20200412.
      View in: PubMed
    8. Maeda Y, Schipani E, Densmore MJ, Lanske B. Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor. Bone. 2010 Feb; 46(2):472-8. PMID: 19761883.
      View in: PubMed
    9. Koyama E, Young B, Nagayama M, Shibukawa Y, Enomoto-Iwamoto M, Iwamoto M, Maeda Y, Lanske B, Song B, Serra R, Pacifici M. Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. Development. 2007 Jun; 134(11):2159-69. PMID: 17507416.
      View in: PubMed
    10. Maeda Y, Nakamura E, Nguyen MT, Suva LJ, Swain FL, Razzaque MS, Mackem S, Lanske B. Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6382-7. PMID: 17409191.
      View in: PubMed
    11. Maeda Y, Tsuji K, Nifuji A, Noda M. Inhibitory helix-loop-helix transcription factors Id1/Id3 promote bone formation in vivo. J Cell Biochem. 2004 Oct 1; 93(2):337-44. PMID: 15368360.
      View in: PubMed
    12. Kida Y, Maeda Y, Shiraishi T, Suzuki T, Ogura T. Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis. Development. 2004 Sep; 131(17):4179-87. PMID: 15280207.
      View in: PubMed
    13. Ohyama Y, Nifuji A, Maeda Y, Amagasa T, Noda M. Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis. Endocrinology. 2004 Oct; 145(10):4685-92. PMID: 15217980.
      View in: PubMed
    14. Matsumoto K, Nishihara S, Kamimura M, Shiraishi T, Otoguro T, Uehara M, Maeda Y, Ogura K, Lumsden A, Ogura T. The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation. Nat Neurosci. 2004 Jun; 7(6):605-12. PMID: 15133517.
      View in: PubMed
    15. Maeda Y, Noda M. Coordinated development of embryonic long bone on chorioallantoic membrane in ovo prevents perichondrium-derived suppressive signals against cartilage growth. Bone. 2003 Jan; 32(1):27-34. PMID: 12584033.
      View in: PubMed
    16. Noda M, Kashimada K, Takamoto M, Yumoto K, Maeda Y, Usui M, Ishijima M. [The meaning of phosphate in bone formation]. Clin Calcium. 2001 Oct; 11(10):1315-20. PMID: 15775646.
      View in: PubMed
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