 Yukiko Maeda PhD
| Title | Instructor |
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| Institution | University of Massachusetts Medical School |
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| Department | Medicine |
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| Address | University of Massachusetts Medical School
368 Plantation Street, AS6-2043
Worcester MA 01605
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| Phone | 774-455-4207 |
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| vCard | Download vCard |
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| Institution | UMMS - School of Medicine |
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| Department | Gene Therapy Center |
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| Institution | UMMS - School of Medicine |
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| Department | Medicine |
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| Division | Rheumatology |
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 Biography | Ritsumeikan University, Shiga, , Japan | BS | | Mathematical Physics | | Nara Institute of Science and Technology, Nara, , Japan | MS | | Biosciences | | Tokyo Medical and Dental University, Tokyo, , Japan | PHD | | Molecular Pharmacology | | Harvard School of Dental Medicine, Boston, MA | Research associate | 07/2010 | Bone Biology | | University of Massachusetts Medical School, Worcester, MA | Post Doctoral Fellow | 07/2012 | micro RNA |
| 2003 | Super Student award, Tokyo Medical and Dental University | | 2003 | Travel Award, International Bone and Mineral Society | | 2006 | Harold M. Frost Young Investigator Award, American Society for Bone and Mineral Research | | 2006 | Young Investigator Award, American Society for Bone and Mineral Research | | 2006 | Dean's Scholars Award, Harvard School of Dental Medicine | | 2007 | Dean's Scholars Award, Harvard School of Dental Medicine | | 2016 | Joseph P. Healey Grants, University of Massachusetts Joseph P. Healey Endowment |
Overview My focus is on applying my expertise in the area of skeletal biology to develop new therapeutic strategies for bone diseases. Autoimmune diseases such as rheumatoid arthritis and ankylosing spondylitis cause various problems to the bone, including bone erosion, osteoporosis, and ectopic new bone formation, which require new treatment strategies. My recent study elucidated inflamed synovium derived microRNAs regulate bone erosion in rheumatoid arthritis. I am currently developing gene therapy approaches using the recombinant Adeno Associated Virus (rAAV) to treat bone disease. Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Muhuri M, Zhan W, Maeda Y, Li J, Lotun A, Chen J, Sylvia K, Dasgupta I, Arjomandnejad M, Nixon T, Keeler AM, Manokaran S, He R, Su Q, Tai PWL, Gao G. Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction. Front Immunol. 2021; 12:674242. PMID: 33995418.
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Maeda Y, Farina NH, Matzelle MM, Fanning PJ, Lian JB, Gravallese EM. Synovium-derived microRNAs regulate bone pathways in rheumatoid arthritis. J Bone Miner Res. 2017; 32(3):461-472.
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O'Brien W, Fissel BM, Maeda Y, Yan J, Ge X, Gravallese EM, Aliprantis AO, Charles JF. RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis. Arthritis Rheumatol. 2016 Dec; 68(12):2889-2900. PMID: 27563728.
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Shaw AT, Maeda Y, Gravallese EM. IL-17A deficiency promotes periosteal bone formation in a model of inflammatory arthritis. Arthritis Res Ther. 2016 May 10; 18(1):104. PMID: 27165410.
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Matzelle MM, Shaw AT, Baum R, Maeda Y, Li J, Karmakar S, Manning CA, Walsh NC, Rosen V, Gravallese EM. Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation. Scand J Rheumatol. 2016 Oct; 45(5):379-83. PMID: 26982203.
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Hassan MQ, Maeda Y, Taipaleenmaki H, Zhang W, Jafferji M, Gordon JA, Li Z, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells. J Biol Chem. 2012 Dec 7; 287(50):42084-92. PMID: 23060446.
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Correa D, Hesse E, Seriwatanachai D, Kiviranta R, Saito H, Yamana K, Neff L, Atfi A, Coillard L, Sitara D, Maeda Y, Warming S, Jenkins NA, Copeland NG, Horne WC, Lanske B, Baron R. Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010 Oct 19; 19(4):533-46. PMID: 20951345.
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Ochiai T, Shibukawa Y, Nagayama M, Mundy C, Yasuda T, Okabe T, Shimono K, Kanyama M, Hasegawa H, Maeda Y, Lanske B, Pacifici M, Koyama E. Indian hedgehog roles in post-natal TMJ development and organization. J Dent Res. 2010 Apr; 89(4):349-54. PMID: 20200412.
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Maeda Y, Schipani E, Densmore MJ, Lanske B. Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor. Bone. 2010 Feb; 46(2):472-8. PMID: 19761883.
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Koyama E, Young B, Nagayama M, Shibukawa Y, Enomoto-Iwamoto M, Iwamoto M, Maeda Y, Lanske B, Song B, Serra R, Pacifici M. Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. Development. 2007 Jun; 134(11):2159-69. PMID: 17507416.
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Maeda Y, Nakamura E, Nguyen MT, Suva LJ, Swain FL, Razzaque MS, Mackem S, Lanske B. Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6382-7. PMID: 17409191.
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Maeda Y, Tsuji K, Nifuji A, Noda M. Inhibitory helix-loop-helix transcription factors Id1/Id3 promote bone formation in vivo. J Cell Biochem. 2004 Oct 1; 93(2):337-44. PMID: 15368360.
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Kida Y, Maeda Y, Shiraishi T, Suzuki T, Ogura T. Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis. Development. 2004 Sep; 131(17):4179-87. PMID: 15280207.
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Ohyama Y, Nifuji A, Maeda Y, Amagasa T, Noda M. Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis. Endocrinology. 2004 Oct; 145(10):4685-92. PMID: 15217980.
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Matsumoto K, Nishihara S, Kamimura M, Shiraishi T, Otoguro T, Uehara M, Maeda Y, Ogura K, Lumsden A, Ogura T. The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation. Nat Neurosci. 2004 Jun; 7(6):605-12. PMID: 15133517.
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Maeda Y, Noda M. Coordinated development of embryonic long bone on chorioallantoic membrane in ovo prevents perichondrium-derived suppressive signals against cartilage growth. Bone. 2003 Jan; 32(1):27-34. PMID: 12584033.
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Noda M, Kashimada K, Takamoto M, Yumoto K, Maeda Y, Usui M, Ishijima M. [The meaning of phosphate in bone formation]. Clin Calcium. 2001 Oct; 11(10):1315-20. PMID: 15775646.
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| Year | Publications |
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| 2001 | 1 | | 2003 | 1 | | 2004 | 4 | | 2007 | 2 | | 2009 | 1 | | 2010 | 2 | | 2012 | 1 | | 2016 | 3 | | 2017 | 1 | | 2021 | 1 |
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