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Yukiko Maeda PhD

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
368 Plantation Street AS6-2043
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentGene Therapy Center

    InstitutionT.H. Chan School of Medicine

    Collapse Biography 
    Collapse education and training
    Ritsumeikan University, Shiga, , JapanBSMathematical Physics
    Nara Institute of Science and Technology, Nara, , JapanMSBiosciences
    Tokyo Medical and Dental University, Tokyo, , JapanPHDMolecular Pharmacology
    Harvard School of Dental Medicine, Boston, MAResearch associate07/2010Bone Biology
    University of Massachusetts Medical School, Worcester, MAPost Doctoral Fellow07/2012micro RNA
    Collapse awards and honors
    2003Super Student award, Tokyo Medical and Dental University
    2003Travel Award, International Bone and Mineral Society
    2006Harold M. Frost Young Investigator Award, American Society for Bone and Mineral Research
    2006Young Investigator Award, American Society for Bone and Mineral Research
    2006Dean's Scholars Award, Harvard School of Dental Medicine
    2007Dean's Scholars Award, Harvard School of Dental Medicine
    2016Joseph P. Healey Grants, University of Massachusetts Joseph P. Healey Endowment

    Collapse Overview 
    Collapse overview

    My focus is on applying my expertise in the area of skeletal biology to develop new therapeutic strategies for bone diseases. Autoimmune diseases such as rheumatoid arthritis and ankylosing spondylitis cause various problems to the bone, including bone erosion, osteoporosis, and ectopic new bone formation, which require new treatment strategies. My recent study elucidated inflamed synovium derived microRNAs regulate bone erosion in rheumatoid arthritis. I am currently developing gene therapy approaches using the recombinant Adeno Associated Virus (rAAV) to treat bone disease.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stavre Z, Bridgewood C, Zhou Q, Maeda Y, Huang TT, Karman J, Khan A, Giryes S, Sharif K, McGonagle D, Gravallese EM. A role for neutrophils in early enthesitis in spondyloarthritis. Arthritis Res Ther. 2022 01 17; 24(1):24. PMID: 35039073.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    2. Muhuri M, Zhan W, Maeda Y, Li J, Lotun A, Chen J, Sylvia K, Dasgupta I, Arjomandnejad M, Nixon T, Keeler AM, Manokaran S, He R, Su Q, Tai PWL, Gao G. Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction. Front Immunol. 2021; 12:674242. PMID: 33995418.
      Citations: 9     Fields:    Translation:AnimalsCells
    3. Maeda Y, Farina NH, Matzelle MM, Fanning PJ, Lian JB, Gravallese EM. Synovium-derived microRNAs regulate bone pathways in rheumatoid arthritis. J Bone Miner Res. 2017; 32(3):461-472.
    4. O'Brien W, Fissel BM, Maeda Y, Yan J, Ge X, Gravallese EM, Aliprantis AO, Charles JF. RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis. Arthritis Rheumatol. 2016 12; 68(12):2889-2900. PMID: 27563728.
      Citations: 62     Fields:    Translation:Animals
    5. Shaw AT, Maeda Y, Gravallese EM. IL-17A deficiency promotes periosteal bone formation in a model of inflammatory arthritis. Arthritis Res Ther. 2016 05 10; 18(1):104. PMID: 27165410.
      Citations: 39     Fields:    Translation:AnimalsCells
    6. Matzelle MM, Shaw AT, Baum R, Maeda Y, Li J, Karmakar S, Manning CA, Walsh NC, Rosen V, Gravallese EM. Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation. Scand J Rheumatol. 2016 Oct; 45(5):379-83. PMID: 26982203.
      Citations: 11     Fields:    Translation:AnimalsCells
    7. Hassan MQ, Maeda Y, Taipaleenmaki H, Zhang W, Jafferji M, Gordon JA, Li Z, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells. J Biol Chem. 2012 Dec 07; 287(50):42084-92. PMID: 23060446.
      Citations: 149     Fields:    Translation:AnimalsCells
    8. Correa D, Hesse E, Seriwatanachai D, Kiviranta R, Saito H, Yamana K, Neff L, Atfi A, Coillard L, Sitara D, Maeda Y, Warming S, Jenkins NA, Copeland NG, Horne WC, Lanske B, Baron R. Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010 Oct 19; 19(4):533-46. PMID: 20951345.
      Citations: 53     Fields:    Translation:AnimalsCells
    9. Ochiai T, Shibukawa Y, Nagayama M, Mundy C, Yasuda T, Okabe T, Shimono K, Kanyama M, Hasegawa H, Maeda Y, Lanske B, Pacifici M, Koyama E. Indian hedgehog roles in post-natal TMJ development and organization. J Dent Res. 2010 Apr; 89(4):349-54. PMID: 20200412.
      Citations: 36     Fields:    Translation:AnimalsCells
    10. Maeda Y, Schipani E, Densmore MJ, Lanske B. Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor. Bone. 2010 Feb; 46(2):472-8. PMID: 19761883.
      Citations: 20     Fields:    Translation:AnimalsCells
    11. Koyama E, Young B, Nagayama M, Shibukawa Y, Enomoto-Iwamoto M, Iwamoto M, Maeda Y, Lanske B, Song B, Serra R, Pacifici M. Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. Development. 2007 Jun; 134(11):2159-69. PMID: 17507416.
      Citations: 103     Fields:    Translation:AnimalsCells
    12. Maeda Y, Nakamura E, Nguyen MT, Suva LJ, Swain FL, Razzaque MS, Mackem S, Lanske B. Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6382-7. PMID: 17409191.
      Citations: 140     Fields:    Translation:AnimalsCells
    13. Maeda Y, Tsuji K, Nifuji A, Noda M. Inhibitory helix-loop-helix transcription factors Id1/Id3 promote bone formation in vivo. J Cell Biochem. 2004 Oct 01; 93(2):337-44. PMID: 15368360.
      Citations: 28     Fields:    Translation:AnimalsCells
    14. Kida Y, Maeda Y, Shiraishi T, Suzuki T, Ogura T. Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis. Development. 2004 Sep; 131(17):4179-87. PMID: 15280207.
      Citations: 9     Fields:    Translation:AnimalsCells
    15. Ohyama Y, Nifuji A, Maeda Y, Amagasa T, Noda M. Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis. Endocrinology. 2004 Oct; 145(10):4685-92. PMID: 15217980.
      Citations: 21     Fields:    Translation:AnimalsCells
    16. Matsumoto K, Nishihara S, Kamimura M, Shiraishi T, Otoguro T, Uehara M, Maeda Y, Ogura K, Lumsden A, Ogura T. The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation. Nat Neurosci. 2004 Jun; 7(6):605-12. PMID: 15133517.
      Citations: 30     Fields:    Translation:AnimalsCells
    17. Maeda Y, Noda M. Coordinated development of embryonic long bone on chorioallantoic membrane in ovo prevents perichondrium-derived suppressive signals against cartilage growth. Bone. 2003 Jan; 32(1):27-34. PMID: 12584033.
      Citations: 2     Fields:    Translation:Animals
    18. Noda M, Kashimada K, Takamoto M, Yumoto K, Maeda Y, Usui M, Ishijima M. [The meaning of phosphate in bone formation]. Clin Calcium. 2001 Oct; 11(10):1315-20. PMID: 15775646.
      Citations:    Fields:    
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