Manish Muhuri | Profiles RNS

Manish Muhuri PhD

Title	Instructor
Institution	UMass Chan Medical School
Department	Microbiology
Address	UMass Chan Medical School 368 Plantation Street AS6-2005 Worcester MA 01605
Phone	774-329-5612
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Other Positions


Institution	T.H. Chan School of Medicine
Department	Gene Therapy Center
Institution	T.H. Chan School of Medicine
Department	Microbiology

Biography

education and training

University of Delhi, Delhi, , India	BS	Sciences
University of Delhi, Delhi, , India	MS	Biomedical Sciences
National University of Singapore, Singapore, , Singapore	PHD	Biology

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Bradbury A, Markusic D, Muhuri M, Ou L. Editorial: Immunogenicity and toxicity of AAV gene therapy. Front Immunol. 2023; 14:1227231. PMID: 37426652.

Citations: Fields:
All Allergy and Immunology
Hariharan VN, Shin M, Chang CW, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, Cruz J, Chan IL, Liu P, Lim SY, McConnell J, Singh SP, Hildebrand S, Sousa J, Davis SM, Kennedy Z, Ferguson C, Godinho BMDC, Thillier Y, Caiazzi J, Ly S, Muhuri M, Kelly K, Humphries F, Cousineau A, Parsi KM, Li Q, Wang Y, Maehr R, Gao G, Korkin D, McDougall WM, Finberg RW, Fitzgerald KA, Wang JP, Watts JK, Khvorova A. Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2023 03 14; 120(11):e2219523120. PMID: 36893269.

Citations: 4 Fields:
Sci Science
Translation:Humans Animals Cells
Muhuri M, Levy DI, Schulz M, McCarty D, Gao G. Durability of transgene expression after rAAV gene therapy. Mol Ther. 2022 04 06; 30(4):1364-1380. PMID: 35283274.

Citations: 10 Fields:
Mol Molecular Biology The Therapeutics
Translation:Humans Animals Cells
Muhuri M, Gao G. Membranous Bubbles: High-Purity and High-Titer Exosomes as the Potential Solution for Adeno-Associated Viruses to Evade Neutralization? Hum Gene Ther. 2021 Dec; 32(23-24):1427-1429. PMID: 34935455.

Citations: Fields:
Gen Genetics The Therapeutics
Translation:Cells
Arjomandnejad M, Sylvia K, Blackwood M, Nixon T, Tang Q, Muhuri M, Gruntman AM, Gao G, Flotte TR, Keeler AM. Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells. Mol Ther Methods Clin Dev. 2021 Dec 10; 23:490-506. PMID: 34853797.

Citations:
Zhan W, Muhuri M, Tai PWL, Gao G. Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens? Front Immunol. 2021; 12:673699. PMID: 34046041.

Citations: 12 Fields:
All Allergy and Immunology
Translation:Humans Cells
Muhuri M, Zhan W, Maeda Y, Li J, Lotun A, Chen J, Sylvia K, Dasgupta I, Arjomandnejad M, Nixon T, Keeler AM, Manokaran S, He R, Su Q, Tai PWL, Gao G. Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction. Front Immunol. 2021; 12:674242. PMID: 33995418.

Citations: 9 Fields:
All Allergy and Immunology
Translation:Animals Cells
Chan YK, Wang SK, Chu CJ, Copland DA, Letizia AJ, Costa Verdera H, Chiang JJ, Sethi M, Wang MK, Neidermyer WJ, Chan Y, Lim ET, Graveline AR, Sanchez M, Boyd RF, Vihtelic TS, Inciong RGCO, Slain JM, Alphonse PJ, Xue Y, Robinson-McCarthy LR, Tam JM, Jabbar MH, Sahu B, Adeniran JF, Muhuri M, Tai PWL, Xie J, Krause TB, Vernet A, Pezone M, Xiao R, Liu T, Wang W, Kaplan HJ, Gao G, Dick AD, Mingozzi F, McCall MA, Cepko CL, Church GM. Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses. Sci Transl Med. 2021 02 10; 13(580). PMID: 33568518.

Citations: 67 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Muhuri M, Gao G. Oncolytic Virus Alphavirus M1: A New and Promising Weapon to Fight Cancer. Hum Gene Ther. 2021 02; 32(3-4):136-137. PMID: 33621140.

Citations: 2 Fields:
Gen Genetics The Therapeutics
Translation:Humans Cells
Muhuri M, Maeda Y, Ma H, Ram S, Fitzgerald KA, Tai PW, Gao G. Overcoming innate immune barriers that impede AAV gene therapy vectors. J Clin Invest. 2021 01 04; 131(1). PMID: 33393506.

Citations: 44 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
Biscans A, Caiazzi J, McHugh N, Hariharan V, Muhuri M, Khvorova A. Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles. Mol Ther. 2021 04 07; 29(4):1382-1394. PMID: 33348054.

Citations: 19 Fields:
Mol Molecular Biology The Therapeutics
Translation:Humans Animals
Muhuri M, Gao G. Is smaller better? Vaccine targeting recombinant receptor-binding domain might hold the key for mass production of effective prophylactics to fight the COVID-19 pandemic. Signal Transduct Target Ther. 2020 10 06; 5(1):222. PMID: 33024086.

Citations: 2 Fields:
Cel Cell Biology Dru Drug Therapy
Translation:Humans Cells PHPublic Health
Nama S, Muhuri M, Di Pascale F, Quah S, Aswad L, Fullwood M, Sampath P. MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression. Sci Rep. 2019 09 03; 9(1):12718. PMID: 31481748.

Citations: 19 Fields:
Sci Science
Translation:Humans Animals Cells
Xiao Y, Muhuri M, Li S, Qin W, Xu G, Luo L, Li J, Letizia AJ, Wang SK, Chan YK, Wang C, Fuchs SP, Wang D, Su Q, Nahid MA, Church GM, Farzan M, Yang L, Wei Y, Desrosiers RC, Mueller C, Tai PW, Gao G. Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity. JCI Insight. 2019 05 21; 5. PMID: 31112525.

Citations: 19 Fields:
Med Medicine (General)
Translation:Animals Cells
Di Pascale F, Nama S, Muhuri M, Quah S, Ismail HM, Chan XHD, Sundaram GM, Ramalingam R, Burke B, Sampath P. C/EBP? mediates RNA polymerase III-driven transcription of oncomiR-138 in malignant gliomas. Nucleic Acids Res. 2018 01 09; 46(1):336-349. PMID: 29136251.

Citations: 9 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Sundaram GM, Ismail HM, Bashir M, Muhuri M, Vaz C, Nama S, Ow GS, Vladimirovna IA, Ramalingam R, Burke B, Tanavde V, Kuznetsov V, Lane EB, Sampath P. EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis. J Exp Med. 2017 Oct 02; 214(10):2889-2900. PMID: 28827448.

Citations: 29 Fields:
All Allergy and Immunology Med Medicine (General)
Translation:Animals