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Douglas T Golenbock MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB-208
Worcester MA 01605
Phone508-856-5982
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases And Immunology

    InstitutionUMMS - School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentImmunology and Virology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMolecular Genetics and Microbiology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentCenter for AIDS Research


    Collapse Biography 
    Collapse education and training
    University of Michigan, Ann Arbor, Ann Arbor, MI, United StatesBSScience
    University of Michigan Medical School, Ann Arbor, MI, United StatesMD

    Collapse Overview 
    Collapse overview

    Academic Background

    B.S.   (1975)  University of Michigan

    M.D.  (1980)   University of Michigan

    Internship and Residency, Internal Medicine (1980-1983) 

                             George Washington University Hospital

    Infectious Diseases Fellowship (1984-1986)

                 University of Wisconsin Hospitals and Clinics

    Post-doctoral Fellowship (1986-1988)

                 University of Wisconsin Hospitals and Clinics

                 (Christian R.H. Raetz, mentor)

    Post-doctoral Fellowship (1989-1990)

                 Merck Research Laboratories, Rahway, NJ

                 (Christian R.H. Raetz, mentor)

    Assistant Professor of Medicine and Infectious Diseases (1990- 1995)

                 Boston University School of Medicine

    Associate Professor of Medicine and Infectious Diseases (1995-1999)

                 Boston University School of Medicine

    Professor of Medicine and Infectious Diseases (1999-2001)

                 Boston University School of Medicine

    Professor of Medicine and Infectious Diseases (2001-present)

                  UMass Medical School

                 Tenure award:  2004

               

    Innate immunity and Infectious Diseases.Douglas Golenbock, MD

    Dr. Douglas Golenbock is Chief of the Division of Infectious Diseases and Immunology in the Department of Medicine. He holds a joint appointment in the Department of Microbiology and Physiological Systems. The goal of his laboratory is to characterize phagocytic receptors that recognize the presence of microbes in the context of infectious illnesses. As the mechanisms of inflammation in infectious diseases are similar to those associated with sterile inflammation, we also study Alzheimer's Disease.    Virtually all of our work focuses on two groups of receptors: Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in the context of the inflammasome.

     Our entry into the TLR field was heralded by the discovery that TLR4, and MD-2 mediate responses to bacterial endotoxin, a major cause of sepsis. More recently, we have begun to focus on intracellular nucleic acid receptors as regulators of IL-1 production and type I interferons. There are six major projects in the laboratory:

    1. Defining the response to bacterial lipopolysaccharide (LPS, endotoxin). LPS immunologically potent amphipathic glycolipid on the surface of Gram-negative bacteria. It is thought to be responsible for Gram-negative sepsis. This project involves detailed studies of TLR4/MD-2 and adapter molecules that transduce an activation signal. The work is funded via an NIH merit award to Dr. Golenbock.

    2. Characterizing the role of the LPS receptor system, in pelvic inflammatory disease. This project is based upon the realization that Neisseria gonorrhoeae mediates much of its inflammation via the TLR4/MD-2 signaling pathway and is funded via an NIH U19 award that includes other infectious diseases faculty, including Drs. Peter Rice (program PI) and Sanjay Ram.

    3. Defining the innate immune response to P. falciparum malaria. Very little is known about how P. falciparum causes inflammation. We have developed several projects in this area, including basic investigations into nucleic acid receptors and inflammasomes. This is a large project that is a collaboration with two other UMass investigators, Drs. Kate Fitzgerald and Ricardo Gazzinelli. The project is funded via an RO1 to Drs. Golenbock and Fitzgerald.

    4. Defining the innate immune response to Group B streptococcus. We have previously demonstrated that Group B streptococcus activates type I interferon production as a result of hemolysin expression, which allows DNA access to the phagocyte cytosolic compartment. Recent studies also implicate hemolysin as a mediator of NLRP3 activation via the effects of bacterial RNA. This project is a three way collaboration with a bacterial genetics group at the Institut Pasteur (France) headed by Dr. Patrick Trieu-Cuot and a cell biology group at the University of Freiburg (Germany) run by Dr. Philipp Henneke, a former Golenbock post-doctoral fellow, and is funded by an RO1 grant to Dr. Golenbock.

    5. Defining a role for PSTPIP1. PSTPIP1 is a protein that causes an autoinflammatory disorder known as PAPA syndrome: Pogenic Arthritis, Pyoderma gangrenosum and Acne. The disease is due to dysregulation of IL-1 production that probably results from the activation on pyrin, the gene product associated with Familial Mediterranean Fever. Dr. Donghai Wang, a member of the Golenbock laboratory, has engineered mice that are either deficient in PSTPIP1, or that carry the known lesions of PAPA syndrome. It is funded by an R21 grant to Drs. Wang and Golenbock.

    6. Examining the role of the NLRP3 inflammasome in Alzheimers Disease. Alzheimer (AD) is a chronic inflammatory disease that causes premature dementia and death. It appears to be caused, in part, by -amyloid, an insoluble protein that activates the NLRP3 inflammasome in microglial cells, resulting in neuronal cell death.

    One of the major goals of the Golenbock lab and the Division of Infectious Diseases is to promote UMass immunology and the field of innate immunity in general. The Division has organized the state of the art meetng in the field of innate immunity. We have now had four Toll meetings: Toll2004 (Taormina, Italy), Toll2006 (Salvador, Brazil; www.toll2006.org), Toll2008 (Cascais, Portugal; www.toll2008.org) and Toll2011 (Riva del Garda, Italy; www.toll2011.org). Virtually all of the research faculty, students and post-docs in Infectious Diseases attend the Toll meetings, which typically involve ~ 600 participants.

    For More information on Toll related meetings please see

     http://www.youtube.com/watch?v=2rqQOmkiL5o

    For More information on Targeting a new therapy for Alzheimer's pleas see:

     http://www.youtube.com/watch?v=5LXshrNFkXA





    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kalantari P, Harandi OF, Agarwal S, Rus F, Kurt-Jones EA, Fitzgerald KA, Caffrey DR, Golenbock DT. miR-718 Represses Pro-inflammatory Cytokine Production Through Targeting PTEN. J Biol Chem. 2017 Feb 16. PMID: 28209713.
      View in: PubMed
    2. Andrade WA, Firon A, Schmidt T, Hornung V, Fitzgerald KA, Kurt-Jones EA, Trieu-Cuot P, Golenbock DT, Kaminski PA. Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production. Cell Host Microbe. 2016 Jul 13; 20(1):49-59. PMID: 27414497.
      View in: PubMed
    3. Tzeng TC, Schattgen S, Monks B, Wang D, Cerny A, Latz E, Fitzgerald K, Golenbock DT. A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection. Cell Rep. 2016 Jul 12; 16(2):571-82. PMID: 27346360.
      View in: PubMed
    4. Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D. Control of the innate immune response by the mevalonate pathway. Nat Immunol. 2016 Aug; 17(8):922-9. PMID: 27270400.
      View in: PubMed
    5. Andrade WA, Agarwal S, Mo S, Shaffer SA, Dillard JP, Schmidt T, Hornung V, Fitzgerald KA, Kurt-Jones EA, Golenbock DT. Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4. Cell Rep. 2016 Jun 14; 15(11):2438-48. PMID: 27264171.
      View in: PubMed
    6. Ní Cheallaigh C, Sheedy FJ, Harris J, Muñoz-Wolf N, Lee J, West K, McDermott EP, Smyth A, Gleeson LE, Coleman M, Martinez N, Hearnden CH, Tynan GA, Carroll EC, Jones SA, Corr SC, Bernard NJ, Hughes MM, Corcoran SE, O'Sullivan M, Fallon CM, Kornfeld H, Golenbock D, Gordon SV, O'Neill LA, Lavelle EC, Keane J. A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling. Immunity. 2016 Feb 16; 44(2):368-79. PMID: 26885859.
      View in: PubMed
    7. Shaughnessy J, Gulati S, Agarwal S, Unemo M, Ohnishi M, Su XH, Monks BG, Visintin A, Madico G, Lewis LA, Golenbock DT, Reed GW, Rice PA, Ram S. A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae. J Immunol. 2016 Feb 15; 196(4):1732-40. PMID: 26773149.
      View in: PubMed
    8. Rocha BC, Marques PE, Leoratti FM, Junqueira C, Pereira DB, Antonelli LR, Menezes GB, Golenbock DT, Gazzinelli RT. Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria. Cell Rep. 2015 Dec 29; 13(12):2829-41. PMID: 26711347.
      View in: PubMed
    9. Hirako IC, Gallego-Marin C, Ataide MA, Andrade WA, Gravina H, Rocha BC, de Oliveira RB, Pereira DB, Vinetz J, Diamond B, Ram S, Golenbock DT, Gazzinelli RT. DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14+ CD16+ CD64high CD32low Inflammatory Monocytes from Malaria Patients. MBio. 2015 Nov 17; 6(6):e01605-15. PMID: 26578679.
      View in: PubMed
    10. Tamehiro N, Park MH, Hawxhurst V, Nagpal K, Adams ME, Zannis VI, Golenbock DT, Fitzgerald ML. LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux. Biochemistry. 2015 Nov 24; 54(46):6931-41. PMID: 26506427.
      View in: PubMed
    11. Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015 Apr; 14(4):388-405. PMID: 25792098.
      View in: PubMed
    12. Heneka MT, Golenbock DT, Latz E. Innate immunity in Alzheimer's disease. Nat Immunol. 2015 Mar; 16(3):229-36. PMID: 25689443.
      View in: PubMed
    13. Yang H, Wang H, Ju Z, Ragab AA, Lundbäck P, Long W, Valdes-Ferrer SI, He M, Pribis JP, Li J, Lu B, Gero D, Szabo C, Antoine DJ, Harris HE, Golenbock DT, Meng J, Roth J, Chavan SS, Andersson U, Billiar TR, Tracey KJ, Al-Abed Y. MD-2 is required for disulfide HMGB1-dependent TLR4 signaling. J Exp Med. 2015 Jan 12; 212(1):5-14. PMID: 25559892.
      View in: PubMed
    14. Langjahr P, Díaz-Jiménez D, De la Fuente M, Rubio E, Golenbock D, Bronfman FC, Quera R, González MJ, Hermoso MA. Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production. PLoS One. 2014; 9(12):e104624. PMID: 25531754.
      View in: PubMed
    15. Corbett Y, Parapini S, D'Alessandro S, Scaccabarozzi D, Rocha BC, Egan TJ, Omar A, Galastri L, Fitzgerald KA, Golenbock DT, Taramelli D, Basilico N. Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin. Microbes Infect. 2015 Mar; 17(3):184-94. PMID: 25462568.
      View in: PubMed
    16. Gazzinelli RT, Kalantari P, Fitzgerald KA, Golenbock DT. Innate sensing of malaria parasites. Nat Rev Immunol. 2014 Nov; 14(11):744-57. PMID: 25324127.
      View in: PubMed
    17. Antonelli LR, Leoratti FM, Costa PA, Rocha BC, Diniz SQ, Tada MS, Pereira DB, Teixeira-Carvalho A, Golenbock DT, Gonçalves R, Gazzinelli RT. The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria. PLoS Pathog. 2014 Sep; 10(9):e1004393. PMID: 25233271.
      View in: PubMed
    18. Dutra FF, Alves LS, Rodrigues D, Fernandez PL, de Oliveira RB, Golenbock DT, Zamboni DS, Bozza MT. Hemolysis-induced lethality involves inflammasome activation by heme. Proc Natl Acad Sci U S A. 2014 Sep 30; 111(39):E4110-8. PMID: 25225402.
      View in: PubMed
    19. Davaro F, Forde SD, Garfield M, Jiang Z, Halmen K, Tamburro ND, Kurt-Jones E, Fitzgerald KA, Golenbock DT, Wang D. 3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1ß interferes with mature IL-1ß signaling. J Biol Chem. 2014 Jun 6; 289(23):16214-22. PMID: 24790079.
      View in: PubMed
    20. Gupta R, Ghosh S, Monks B, DeOliveira RB, Tzeng TC, Kalantari P, Nandy A, Bhattacharjee B, Chan J, Ferreira F, Rathinam V, Sharma S, Lien E, Silverman N, Fitzgerald K, Firon A, Trieu-Cuot P, Henneke P, Golenbock DT. RNA and ß-hemolysin of group B Streptococcus induce interleukin-1ß (IL-1ß) by activating NLRP3 inflammasomes in mouse macrophages. J Biol Chem. 2014 May 16; 289(20):13701-5. PMID: 24692555.
      View in: PubMed
    21. de Oliveira RB, Wang JP, Ram S, Gazzinelli RT, Finberg RW, Golenbock DT. Increased survival in B-cell-deficient mice during experimental cerebral malaria suggests a role for circulating immune complexes. MBio. 2014 Mar 18; 5(2):e00949-14. PMID: 24643866.
      View in: PubMed
    22. Janssen E, Ozcan E, Liadaki K, Jabara HH, Manis J, Ullas S, Akira S, Fitzgerald KA, Golenbock DT, Geha RS. TRIF signaling is essential for TLR4-driven IgE class switching. J Immunol. 2014 Mar 15; 192(6):2651-8. PMID: 24532577.
      View in: PubMed
    23. De la Fuente M, Franchi L, Araya D, Díaz-Jiménez D, Olivares M, Álvarez-Lobos M, Golenbock D, González MJ, López-Kostner F, Quera R, Núñez G, Vidal R, Hermoso MA. Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome. Int J Med Microbiol. 2014 May; 304(3-4):384-92. PMID: 24581881.
      View in: PubMed
    24. Ataide MA, Andrade WA, Zamboni DS, Wang D, Souza Mdo C, Franklin BS, Elian S, Martins FS, Pereira D, Reed G, Fitzgerald KA, Golenbock DT, Gazzinelli RT. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog. 2014 Jan; 10(1):e1003885. PMID: 24453977.
      View in: PubMed
    25. Kalantari P, DeOliveira RB, Chan J, Corbett Y, Rathinam V, Stutz A, Latz E, Gazzinelli RT, Golenbock DT, Fitzgerald KA. Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria. Cell Rep. 2014 Jan 16; 6(1):196-210. PMID: 24388751.
      View in: PubMed
    26. Liehl P, Zuzarte-Luís V, Chan J, Zillinger T, Baptista F, Carapau D, Konert M, Hanson KK, Carret C, Lassnig C, Müller M, Kalinke U, Saeed M, Chora AF, Golenbock DT, Strobl B, Prudêncio M, Coelho LP, Kappe SH, Superti-Furga G, Pichlmair A, Vigário AM, Rice CM, Fitzgerald KA, Barchet W, Mota MM. Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med. 2014 Jan; 20(1):47-53. PMID: 24362933.
      View in: PubMed
    27. Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA, Moore KJ. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol. 2013 Aug; 14(8):812-20. PMID: 23812099.
      View in: PubMed
    28. Marinotti O, Cerqueira GC, de Almeida LG, Ferro MI, Loreto EL, Zaha A, Teixeira SM, Wespiser AR, Almeida E Silva A, Schlindwein AD, Pacheco AC, Silva AL, Graveley BR, Walenz BP, Lima Bde A, Ribeiro CA, Nunes-Silva CG, de Carvalho CR, Soares CM, de Menezes CB, Matiolli C, Caffrey D, Araújo DA, de Oliveira DM, Golenbock D, Grisard EC, Fantinatti-Garboggini F, de Carvalho FM, Barcellos FG, Prosdocimi F, May G, Azevedo Junior GM, Guimarães GM, Goldman GH, Padilha IQ, Batista Jda S, Ferro JA, Ribeiro JM, Fietto JL, Dabbas KM, Cerdeira L, Agnez-Lima LF, Brocchi M, de Carvalho MO, Teixeira Mde M, Diniz Maia Mde M, Goldman MH, Cruz Schneider MP, Felipe MS, Hungria M, Nicolás MF, Pereira M, Montes MA, Cantão ME, Vincentz M, Rafael MS, Silverman N, Stoco PH, Souza RC, Vicentini R, Gazzinelli RT, Neves Rde O, Silva R, Astolfi-Filho S, Maciel TE, Urményi TP, Tadei WP, Camargo EP, de Vasconcelos AT. The genome of Anopheles darlingi, the main neotropical malaria vector. Nucleic Acids Res. 2013 Aug; 41(15):7387-400. PMID: 23761445.
      View in: PubMed
    29. Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2209-18. PMID: 23716675.
      View in: PubMed
    30. O'Neill LA, Golenbock D, Bowie AG. The history of Toll-like receptors - redefining innate immunity. Nat Rev Immunol. 2013 Jun; 13(6):453-60. PMID: 23681101.
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    31. Souza-Fonseca-Guimaraes F, Parlato M, de Oliveira RB, Golenbock D, Fitzgerald K, Shalova IN, Biswas SK, Cavaillon JM, Adib-Conquy M. Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING). J Biol Chem. 2013 Apr 12; 288(15):10715-21. PMID: 23443666.
      View in: PubMed
    32. Firon A, Tazi A, Da Cunha V, Brinster S, Sauvage E, Dramsi S, Golenbock DT, Glaser P, Poyart C, Trieu-Cuot P. The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus. PLoS Pathog. 2013 Feb; 9(2):e1003179. PMID: 23436996.
      View in: PubMed
    33. Schamber-Reis BL, Petritus PM, Caetano BC, Martinez ER, Okuda K, Golenbock D, Scott P, Gazzinelli RT. UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major. J Biol Chem. 2013 Mar 08; 288(10):7127-36. PMID: 23325805.
      View in: PubMed
    34. Wang D, Höing S, Patterson HC, Ahmad UM, Rathinam VA, Rajewsky K, Fitzgerald KA, Golenbock DT. Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. J Biol Chem. 2013 Feb 15; 288(7):4594-601. PMID: 23293022.
      View in: PubMed
    35. Andrade WA, Souza Mdo C, Ramos-Martinez E, Nagpal K, Dutra MS, Melo MB, Bartholomeu DC, Ghosh S, Golenbock DT, Gazzinelli RT. Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice. Cell Host Microbe. 2013 Jan 16; 13(1):42-53. PMID: 23290966.
      View in: PubMed
    36. Elfawal MA, Towler MJ, Reich NG, Golenbock D, Weathers PJ, Rich SM. Dried whole plant Artemisia annua as an antimalarial therapy. PLoS One. 2012 Dec 20; 7(12):e52746. PMID: 23289055.
      View in: PubMed
    37. Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 2013 Jan 31; 493(7434):674-8. PMID: 23254930.
      View in: PubMed
    38. Basset A, Zhang F, Benes C, Sayeed S, Herd M, Thompson C, Golenbock DT, Camilli A, Malley R. Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein. J Biol Chem. 2013 Jan 25; 288(4):2665-75. PMID: 23233677.
      View in: PubMed
    39. Ramirez A, Rathinam V, Fitzgerald KA, Golenbock DT, Mathew A. Defective pro-IL-1ß responses in macrophages from aged mice. Immun Ageing. 2012 Dec 11; 9(1):27. PMID: 23228123.
      View in: PubMed
    40. Hafner-Bratkovic I, Bencina M, Fitzgerald KA, Golenbock D, Jerala R. NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1ß and neuronal toxicity. Cell Mol Life Sci. 2012 Dec; 69(24):4215-28. PMID: 22926439.
      View in: PubMed
    41. Leoratti FM, Trevelin SC, Cunha FQ, Rocha BC, Costa PA, Gravina HD, Tada MS, Pereira DB, Golenbock DT, Antonelli LR, Gazzinelli RT. Neutrophil paralysis in Plasmodium vivax malaria. PLoS Negl Trop Dis. 2012; 6(6):e1710. PMID: 22745844.
      View in: PubMed
    42. Lehmann SM, Krüger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Kälin R, Franzoni E, Rybak A, Nguyen D, Veh R, Ninnemann O, Peters O, Nitsch R, Heppner FL, Golenbock D, Schott E, Ploegh HL, Wulczyn FG, Lehnardt S. An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci. 2012 Jun; 15(6):827-35. PMID: 22610069.
      View in: PubMed
    43. Jabara HH, McDonald DR, Janssen E, Massaad MJ, Ramesh N, Borzutzky A, Rauter I, Benson H, Schneider L, Baxi S, Recher M, Notarangelo LD, Wakim R, Dbaibo G, Dasouki M, Al-Herz W, Barlan I, Baris S, Kutukculer N, Ochs HD, Plebani A, Kanariou M, Lefranc G, Reisli I, Fitzgerald KA, Golenbock D, Manis J, Keles S, Ceja R, Chatila TA, Geha RS. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2012 May 13; 13(6):612-20. PMID: 22581261.
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    44. Levitz SM, Golenbock DT. Beyond empiricism: informing vaccine development through innate immunity research. Cell. 2012 Mar 16; 148(6):1284-92. PMID: 22424235.
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    45. Fortes GB, Alves LS, de Oliveira R, Dutra FF, Rodrigues D, Fernandez PL, Souto-Padron T, De Rosa MJ, Kelliher M, Golenbock D, Chan FK, Bozza MT. Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. Blood. 2012 Mar 8; 119(10):2368-75. PMID: 22262768.
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    46. Costa A, Gupta R, Signorino G, Malara A, Cardile F, Biondo C, Midiri A, Galbo R, Trieu-Cuot P, Papasergi S, Teti G, Henneke P, Mancuso G, Golenbock DT, Beninati C. Activation of the NLRP3 inflammasome by group B streptococci. J Immunol. 2012 Feb 15; 188(4):1953-60. PMID: 22250086.
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    47. Deshmukh SD, Müller S, Hese K, Rauch KS, Wennekamp J, Takeuchi O, Akira S, Golenbock DT, Henneke P. NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA. J Immunol. 2012 Jan 15; 188(2):774-80. PMID: 22184724.
      View in: PubMed
    48. Meng J, Gong M, Björkbacka H, Golenbock DT. Genome-wide expression profiling and mutagenesis studies reveal that lipopolysaccharide responsiveness appears to be absolutely dependent on TLR4 and MD-2 expression and is dependent upon intermolecular ionic interactions. J Immunol. 2011 Oct 1; 187(7):3683-93. PMID: 21865549.
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    49. Sharma S, DeOliveira RB, Kalantari P, Parroche P, Goutagny N, Jiang Z, Chan J, Bartholomeu DC, Lauw F, Hall JP, Barber GN, Gazzinelli RT, Fitzgerald KA, Golenbock DT. Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity. 2011 Aug 26; 35(2):194-207. PMID: 21820332.
      View in: PubMed
    50. Caetano BC, Carmo BB, Melo MB, Cerny A, dos Santos SL, Bartholomeu DC, Golenbock DT, Gazzinelli RT. Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi. J Immunol. 2011 Aug 15; 187(4):1903-11. PMID: 21753151.
      View in: PubMed
    51. Gallego C, Golenbock D, Gomez MA, Saravia NG. Toll-like receptors participate in macrophage activation and intracellular control of Leishmania (Viannia) panamensis. Infect Immun. 2011 Jul; 79(7):2871-9. PMID: 21518783.
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    145. Zamboni DS, Campos MA, Torrecilhas AC, Kiss K, Samuel JE, Golenbock DT, Lauw FN, Roy CR, Almeida IC, Gazzinelli RT. Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. J Biol Chem. 2004 Dec 24; 279(52):54405-15. PMID: 15485838.
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    153. Björkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, Lee MA, Means T, Halmen K, Luster AD, Golenbock DT, Freeman MW. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med. 2004 Apr; 10(4):416-21. PMID: 15034566.
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    154. Hasebe A, Yoshimura A, Into T, Kataoka H, Tanaka S, Arakawa S, Ishikura H, Golenbock DT, Sugaya T, Tsuchida N, Kawanami M, Hara Y, Shibata K. Biological activities of Bacteroides forsythus lipoproteins and their possible pathological roles in periodontal disease. Infect Immun. 2004 Mar; 72(3):1318-25. PMID: 14977934.
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    156. Latz E, Franko J, Golenbock DT, Schreiber JR. Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity. J Immunol. 2004 Feb 15; 172(4):2431-8. PMID: 14764714.
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    192. Sasu S, LaVerda D, Qureshi N, Golenbock DT, Beasley D. Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation. Circ Res. 2001 Aug 3; 89(3):244-50. PMID: 11485974.
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    221. Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem. 1999 Apr 16; 274(16):10689-92. PMID: 10196138.
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    222. Solomon KR, Kurt-Jones EA, Saladino RA, Stack AM, Dunn IF, Ferretti M, Golenbock D, Fleisher GR, Finberg RW. Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide. J Clin Invest. 1998 Dec 1; 102(11):2019-27. PMID: 9835628.
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    223. Ingalls RR, Monks BG, Savedra R, Christ WJ, Delude RL, Medvedev AE, Espevik T, Golenbock DT. CD11/CD18 and CD14 share a common lipid A signaling pathway. J Immunol. 1998 Nov 15; 161(10):5413-20. PMID: 9820516.
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    224. Bliss CM, Golenbock DT, Keates S, Linevsky JK, Kelly CP. Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes. Infect Immun. 1998 Nov; 66(11):5357-63. PMID: 9784544.
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    225. Delude RL, Yoshimura A, Ingalls RR, Golenbock DT. Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction. J Immunol. 1998 Sep 15; 161(6):3001-9. PMID: 9743364.
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    226. Fenton MJ, Golenbock DT. LPS-binding proteins and receptors. J Leukoc Biol. 1998 Jul; 64(1):25-32. PMID: 9665271.
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    227. Medvedev AE, Flo T, Ingalls RR, Golenbock DT, Teti G, Vogel SN, Espevik T. Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls. J Immunol. 1998 May 1; 160(9):4535-42. PMID: 9574560.
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    228. Ingalls RR, Arnaout MA, Delude RL, Flaherty S, Savedra R, Golenbock DT. The CD11/CD18 integrins: characterization of three novel LPS signaling receptors. Prog Clin Biol Res. 1998; 397:107-17. PMID: 9575552.
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    229. Wurfel MM, Monks BG, Ingalls RR, Dedrick RL, Delude R, Zhou D, Lamping N, Schumann RR, Thieringer R, Fenton MJ, Wright SD, Golenbock D. Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact. J Exp Med. 1997 Dec 15; 186(12):2051-6. PMID: 9396775.
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    230. Flaherty SF, Golenbock DT, Milham FH, Ingalls RR. CD11/CD18 leukocyte integrins: new signaling receptors for bacterial endotoxin. J Surg Res. 1997 Nov; 73(1):85-9. PMID: 9441798.
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    231. Pollack M, Ohl CA, Golenbock DT, Di Padova F, Wahl LM, Koles NL, Guelde G, Monks BG. Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions. J Immunol. 1997 Oct 1; 159(7):3519-30. PMID: 9317151.
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    232. Ryan LK, Golenbock DT, Wu J, Vermeulen MW. Characterization of proinflammatory cytokine production and CD14 expression by murine alveolar macrophage cell lines. In Vitro Cell Dev Biol Anim. 1997 Sep; 33(8):647-53. PMID: 9338148.
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    233. Ingalls RR, Arnaout MA, Golenbock DT. Outside-in signaling by lipopolysaccharide through a tailless integrin. J Immunol. 1997 Jul 1; 159(1):433-8. PMID: 9200483.
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    234. Qureshi N, Kaltashov I, Walker K, Doroshenko V, Cotter RJ, Takayama K, Sievert TR, Rice PA, Lin JS, Golenbock DT. Structure of the monophosphoryl lipid A moiety obtained from the lipopolysaccharide of Chlamydia trachomatis. J Biol Chem. 1997 Apr 18; 272(16):10594-600. PMID: 9099706.
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    235. Levitz SM, Tabuni A, Kozel TR, MacGill RS, Ingalls RR, Golenbock DT. Binding of Cryptococcus neoformans to heterologously expressed human complement receptors. Infect Immun. 1997 Mar; 65(3):931-5. PMID: 9038299.
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    236. Lodie TA, Savedra R, Golenbock DT, Van Beveren CP, Maki RA, Fenton MJ. Stimulation of macrophages by lipopolysaccharide alters the phosphorylation state, conformation, and function of PU.1 via activation of casein kinase II. J Immunol. 1997 Feb 15; 158(4):1848-56. PMID: 9029125.
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    237. Lo SK, Golenbock DT, Sass PM, Maskati A, Xu H, Silverstein RL. Engagement of the Lewis X antigen (CD15) results in monocyte activation. Blood. 1997 Jan 1; 89(1):307-14. PMID: 8978306.
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    238. Savedra R, Delude RL, Ingalls RR, Fenton MJ, Golenbock DT. Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system. J Immunol. 1996 Sep 15; 157(6):2549-54. PMID: 8805656.
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    239. Levitz SM, Tabuni A, Nong SH, Golenbock DT. Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide. Infect Immun. 1996 Mar; 64(3):945-51. PMID: 8641805.
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    240. Delude RL, Savedra R, Zhao H, Thieringer R, Yamamoto S, Fenton MJ, Golenbock DT. CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20):9288-92. PMID: 7568119.
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    241. Ingalls RR, Rice PA, Qureshi N, Takayama K, Lin JS, Golenbock DT. The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated. Infect Immun. 1995 Aug; 63(8):3125-30. PMID: 7542638.
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    242. Landay AL, Brambilla D, Pitt J, Hillyer G, Golenbock D, Moye J, Landesman S, Kagan J. Interlaboratory variability of CD8 subset measurements by flow cytometry and its applications to multicenter clinical trials. NAID/NICHD Women and Infants Transmission Study Group. Clin Diagn Lab Immunol. 1995 Jul; 2(4):462-8. PMID: 7583925.
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    243. Golenbock DT, Bach RR, Lichenstein H, Juan TS, Tadavarthy A, Moldow CF. Soluble CD14 promotes LPS activation of CD14-deficient PNH monocytes and endothelial cells. J Lab Clin Med. 1995 May; 125(5):662-71. PMID: 7537790.
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    244. Ingalls RR, Golenbock DT. CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide. J Exp Med. 1995 Apr 1; 181(4):1473-9. PMID: 7535339.
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    245. Stern A, Engelhardt R, Foster C, Golenbock D, Hildebrandt J, Landmann R, Mayer P, Stütz P. SDZ MRL 953, a lipid A analog as selective cytokine inducer. Prog Clin Biol Res. 1995; 392:549-65. PMID: 8524963.
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    246. Delude RL, Savedra R, Yamamoto S, Golenbock DT. Use of CD14 transfected cells to study LPS-antagonist action. Prog Clin Biol Res. 1995; 392:487-97. PMID: 8524956.
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    247. Fagan MA, Liu Y, Stütz P, Vyplel H, Golenbock DT. Acyclic analogue of lipid A stimulates TNF-alpha and arachidonate release via a unique LPS-signaling pathway. J Immunol. 1994 Dec 1; 153(11):5230-8. PMID: 7525728.
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    248. Delude RL, Fenton MJ, Savedra R, Perera PY, Vogel SN, Thieringer R, Golenbock DT. CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity. J Biol Chem. 1994 Sep 2; 269(35):22253-60. PMID: 7520914.
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    249. Levitz SM, Tabuni A, Kornfeld H, Reardon CC, Golenbock DT. Production of tumor necrosis factor alpha in human leukocytes stimulated by Cryptococcus neoformans. Infect Immun. 1994 May; 62(5):1975-81. PMID: 8168965.
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    250. Golenbock DT, Liu Y, Millham FH, Freeman MW, Zoeller RA. Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin. J Biol Chem. 1993 Oct 15; 268(29):22055-9. PMID: 7691822.
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    251. Lynn WA, Liu Y, Golenbock DT. Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide. Infect Immun. 1993 Oct; 61(10):4452-61. PMID: 7691750.
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    252. Lynn WA, Golenbock DT. Lipopolysaccharide antagonists. Immunol Today. 1992 Jul; 13(7):271-6. PMID: 1388655.
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    253. Lynn WA, Raetz CR, Qureshi N, Golenbock DT. Lipopolysaccharide-induced stimulation of CD11b/CD18 expression on neutrophils. Evidence of specific receptor-based response and inhibition by lipid A-based antagonists. J Immunol. 1991 Nov 1; 147(9):3072-9. PMID: 1717586.
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    254. Golenbock DT, Hampton RY, Qureshi N, Takayama K, Raetz CR. Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes. J Biol Chem. 1991 Oct 15; 266(29):19490-8. PMID: 1918061.
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    255. Hampton RY, Golenbock DT, Penman M, Krieger M, Raetz CR. Recognition and plasma clearance of endotoxin by scavenger receptors. Nature. 1991 Jul 25; 352(6333):342-4. PMID: 1852209.
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    256. Golenbock DT, Hampton RY, Raetz CR, Wright SD. Human phagocytes have multiple lipid A-binding sites. Infect Immun. 1990 Dec; 58(12):4069-75. PMID: 1979320.
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    257. Relman D, Tuomanen E, Falkow S, Golenbock DT, Saukkonen K, Wright SD. Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis. Cell. 1990 Jun 29; 61(7):1375-82. PMID: 2364431.
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    258. Birkland TP, Cornwell RD, Golenbock DT, Proctor RA. Comparative study of lipopolysaccharide-, lipid IVa-, and lipid X-induced tumor necrosis factor production in murine macrophage-like cell lines. Adv Exp Med Biol. 1990; 256:399-402. PMID: 2327296.
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    259. Cornwell RD, Golenbock DT, Proctor RA. Lipopolysaccharide, but not lethal infection, releases tumor necrosis factor in mice. Adv Exp Med Biol. 1990; 256:585-8. PMID: 2327303.
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    260. Golenbock DT, Guerra J, Pfister J, Golubjatnikov R, Tejada A, Abugattas J, Kemper R, Maki DG. Absence of infection with human immunodeficiency virus in Peruvian prostitutes. AIDS Res Hum Retroviruses. 1988 Dec; 4(6):493-9. PMID: 3219237.
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    261. Hampton RY, Golenbock DT, Raetz CR. Lipid A binding sites in membranes of macrophage tumor cells. J Biol Chem. 1988 Oct 15; 263(29):14802-7. PMID: 3170565.
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    262. Golenbock DT, Leggett JE, Rasmussen P, Craig WA, Raetz CR, Proctor RA. Lipid X protects mice against fatal Escherichia coli infection. Infect Immun. 1988 Apr; 56(4):779-84. PMID: 3278981.
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    263. Raetz CR, Brozek KA, Clementz T, Coleman JD, Galloway SM, Golenbock DT, Hampton RY. Gram-negative endotoxin: a biologically active lipid. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:973-82. PMID: 2474409.
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    264. Golenbock DT, Ebert S, Will JA, Proctor RA. Elimination and tissue distribution of the monosaccharide lipid A precursor, lipid X, in mice and sheep. Antimicrob Agents Chemother. 1988 Jan; 32(1):37-41. PMID: 3348611.
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    265. Golenbock DT, Will JA, Raetz CR, Proctor RA. Lipid X ameliorates pulmonary hypertension and protects sheep from death due to endotoxin. Infect Immun. 1987 Oct; 55(10):2471-6. PMID: 3308707.
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    266. Kratzke RA, Golenbock DT. Pyomyositis and hepatic abscess in association with Aeromonas hydrophila sepsis. Am J Med. 1987 Aug; 83(2):347-9. PMID: 3618636.
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