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Seongkyu Yoon PhD

Title
InstitutionUniversity of Massachusetts Lowell
DepartmentChemical Engineering
AddressPerry Hall, Room 310
Lowell, MA 01854
Phone978-934-4741
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Qin J, Liu N, Abid U, Coleman SM, Wang Y, Fu Q, Yoon S, Alper HS, Xie D. Metabolic Engineering of Yarrowia lipolytica for Conversion of Waste Cooking Oil into Omega-3 Eicosapentaenoic Acid. ACS Eng Au. 2025 Apr 16; 5(2):128-139. PMID: 40256493.
      Citations:    
    2. Wang Y, Fu Q, Sha S, Yoon S. Interferon inhibitors increase rAAV production in HEK293 cells. J Biotechnol. 2025 Mar; 399:9-18. PMID: 39824361.
      Citations:    
    3. Liang G, Sha S, Wang Z, Liu H, Yoon S. Soft-sensor model development for CHO growth/production, intracellular metabolite, and glycan predictions. Front Mol Biosci. 2024; 11:1441885. PMID: 39502716.
      Citations:    
    4. Fu Q, Wang Y, Qin J, Xie D, McNally D, Yoon S. Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells. Appl Microbiol Biotechnol. 2024 Sep 04; 108(1):459. PMID: 39230729.
      Citations:    
    5. Suk Lee Y, Lee J, Fang K, Gee GV, Rogers B, McNally D, Yoon S. Separation of full, empty, and partial adeno-associated virus capsids via anion-exchange chromatography with continuous recycling and accumulation. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Jul 15; 1242:124206. PMID: 38908134.
      Citations:    
    6. Wang Y, Fu Q, Park SY, Lee YS, Park SY, Lee DY, Yoon S. Decoding cellular mechanism of recombinant adeno-associated virus (rAAV) and engineering host-cell factories toward intensified viral vector manufacturing. Biotechnol Adv. 2024 Mar-Apr; 71:108322. PMID: 38336188.
      Citations:    Fields:    
    7. Marx R, Liu H, Yoon S, Xie D. CFD evaluation of hydrophobic feedstock bench-scale fermenters for efficient high agitation volumetric mass transfer. Biotechnol J. 2024 Feb; 19(2):e2300384. PMID: 38403465.
      Citations:    
    8. Polanco A, Liang G, Park S, Wang Y, Graham RJ, Yoon S. Trace metal optimization in CHO cell culture through statistical design of experiments. Biotechnol Prog. 2023 Nov-Dec; 39(6):e3368. PMID: 37497992.
      Citations:    Fields:    Translation:AnimalsCells
    9. Fu Q, Lee YS, Green EA, Wang Y, Park SY, Polanco A, Lee KH, Betenbaugh M, McNally D, Yoon S. Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing. Biotechnol Bioeng. 2023 Nov; 120(11):3148-3162. PMID: 37475681.
      Citations:    Fields:    
    10. Wang Y, Fu Q, Lee YS, Sha S, Yoon S. Transcriptomic features reveal molecular signatures associated with recombinant adeno-associated virus production in HEK293 cells. Biotechnol Prog. 2023 Jul-Aug; 39(4):e3346. PMID: 37130170.
      Citations:    Fields:    Translation:HumansCells
    11. Fu Q, Polanco A, Lee YS, Yoon S. Critical challenges and advances in recombinant adeno-associated virus (rAAV) biomanufacturing. Biotechnol Bioeng. 2023 09; 120(9):2601-2621. PMID: 37126355.
      Citations: 2     Fields:    Translation:HumansCells
    12. Hoang D, Kuang B, Liang G, Wang Z, Yoon S. Modulation of nutrient precursors for controlling metabolic inhibitors by genome-scale flux balance analysis. Biotechnol Prog. 2023 03; 39(2):e3313. PMID: 36367527.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Morris C, Madhavarao CN, Yoon S, Ashraf M. Single in-line biomass probe detects CHO cell growth by capacitance and bacterial contamination by conductivity in bioreactor. Biotechnol J. 2021 Dec; 16(12):e2100126. PMID: 34591352.
      Citations: 2     Fields:    Translation:AnimalsCells
    14. Kuang B, Dhara VG, Hoang D, Jenkins J, Ladiwala P, Tan Y, Shaffer SA, Galbraith SC, Betenbaugh MJ, Yoon S. Identification of novel inhibitory metabolites and impact verification on growth and protein synthesis in mammalian cells. Metab Eng Commun. 2021 Dec; 13:e00182. PMID: 34522610.
      Citations:    
    15. Morris C, Lee YS, Yoon S. Adventitious agent detection methods in bio-pharmaceutical applications with a focus on viruses, bacteria, and mycoplasma. Curr Opin Biotechnol. 2021 10; 71:105-114. PMID: 34325176.
      Citations: 2     Fields:    Translation:Cells
    16. Hoang D, Galbraith S, Kuang B, Johnson A, Yoon S. Characterization of Chinese hamster ovary cell culture feed media precipitate. Biotechnol Prog. 2021 09; 37(5):e3188. PMID: 34165891.
      Citations: 3     Fields:    Translation:AnimalsCells
    17. Graham RJ, Mohammad A, Liang G, Fu Q, Kuang B, Polanco A, Lee YS, Marcus RK, Yoon S. Effect of iron addition on mAb productivity and oxidative stress in Chinese hamster ovary culture. Biotechnol Prog. 2021 09; 37(5):e3181. PMID: 34106525.
      Citations: 1     Fields:    Translation:AnimalsCells
    18. Liu H, Meyer R, Flamm M, Wareham L, Metzger M, Tantuccio A, Yoon S. Optimization of Critical Quality Attributes in Tablet Film Coating and Design Space Determination Using Pilot-Scale Experimental Data. AAPS PharmSciTech. 2021 Jan 03; 22(1):17. PMID: 33389197.
      Citations:    Fields:    
    19. Behere K, Yoon S. n-Layer BET adsorption isotherm modeling for multimeric Protein A ligand and its lifetime determination. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jan 01; 1162:122434. PMID: 33302227.
      Citations: 1     Fields:    Translation:Cells
    20. Huang Z, Galbraith SC, Cha B, Liu H, Park S, Flamm MH, Metzger M, Tantuccio A, Yoon S. Effects of process parameters on tablet critical quality attributes in continuous direct compression: a case study of integrating data-driven statistical models and mechanistic compaction models. Pharm Dev Technol. 2020 Dec; 25(10):1204-1215. PMID: 32808839.
      Citations:    Fields:    
    21. Behere K, Yoon S. Chromatography bioseparation technologies and in-silico modelings for continuous production of biotherapeutics. J Chromatogr A. 2020 Sep 13; 1627:461376. PMID: 32823091.
      Citations: 5     Fields:    
    22. Liu H, Rivnay B, Avery K, Myung JH, Kozak D, Landrau N, Nivorozhkin A, Ashraf M, Yoon S. Optimization of the manufacturing process of a complex amphotericin B liposomal formulation using quality by design approach. Int J Pharm. 2020 Jul 30; 585:119473. PMID: 32473373.
      Citations: 2     Fields:    
    23. Sha S, Handelman G, Liu N, Xie D, Yoon S. At-line N-linked glycan profiling for monoclonal antibodies with advanced sample preparation and high-performance liquid chromatography. J Biosci Bioeng. 2020 Sep; 130(3):327-333. PMID: 32439286.
      Citations: 1     Fields:    Translation:Humans
    24. Sha S, Handelman G, Agarabi C, Yoon S. A high-resolution measurement of nucleotide sugars by using ion-pair reverse chromatography and tandem columns. Anal Bioanal Chem. 2020 Jun; 412(15):3683-3693. PMID: 32300845.
      Citations: 3     Fields:    Translation:AnimalsCells
    25. Polanco A, Kuang B, Yoon S. Bioprocess Technologies that Preserve the Quality of iPSCs. Trends Biotechnol. 2020 10; 38(10):1128-1140. PMID: 32941792.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    26. Graham RJ, Bhatia H, Yoon S. Consequences of trace metal variability and supplementation on Chinese hamster ovary (CHO) cell culture performance: A review of key mechanisms and considerations. Biotechnol Bioeng. 2019 12; 116(12):3446-3456. PMID: 31403183.
      Citations: 10     Fields:    Translation:AnimalsCells
    27. Cha B, Galbraith SC, Liu H, Park SY, Huang Z, O'Connor T, Lee S, Yoon S. A Thermodynamic Balance Model for Liquid Film Drying Kinetics of a Tablet Film Coating and Drying Process. AAPS PharmSciTech. 2019 Jun 03; 20(5):209. PMID: 31161386.
      Citations: 1     Fields:    Translation:Cells
    28. Soong YV, Liu N, Yoon S, Lawton C, Xie D. Cellular and metabolic engineering of oleaginous yeast Yarrowia lipolytica for bioconversion of hydrophobic substrates into high-value products. Eng Life Sci. 2019 Jun; 19(6):423-443. PMID: 32625020.
      Citations:    
    29. Park SY, Reimonn TM, Agarabi CD, Brorson KA, Yoon S. Metabolic responses and pathway changes of mammalian cells under different culture conditions with media supplementations. Biotechnol Prog. 2018 05; 34(3):793-805. PMID: 29464928.
      Citations: 1     Fields:    Translation:AnimalsCells
    30. Behere K, Cha B, Yoon S. Protein a resin lifetime study: Evaluation of protein a resin performance with a model-based approach in continuous capture. Prep Biochem Biotechnol. 2018 Mar 16; 48(3):242-256. PMID: 29355458.
      Citations:    Fields:    Translation:Cells
    31. Sha S, Bhatia H, Yoon S. An RNA-seq based transcriptomic investigation into the productivity and growth variants with Chinese hamster ovary cells. J Biotechnol. 2018 Apr 10; 271:37-46. PMID: 29476805.
      Citations: 3     Fields:    Translation:AnimalsCells
    32. Liu H, Galbraith SC, Park SY, Cha B, Huang Z, Meyer RF, Flamm MH, O'Connor T, Lee S, Yoon S. Assessment of spatial heterogeneity in continuous twin screw wet granulation process using three-compartmental population balance model. Pharm Dev Technol. 2019 Jan; 24(1):105-117. PMID: 29336653.
      Citations: 3     Fields:    
    33. Galbraith SC, Liu H, Cha B, Park SY, Huang Z, Yoon S. Modeling and simulation of continuous powder blending applied to a continuous direct compression process. Pharm Dev Technol. 2018 Dec; 23(10):1097-1107. PMID: 29304722.
      Citations: 2     Fields:    
    34. Bhatia H, Mehdizadeh H, Drapeau D, Yoon S. In-line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics models. Eng Life Sci. 2018 Jan; 18(1):55-61. PMID: 32624861.
      Citations:    
    35. Huang Z, Lee DY, Yoon S. Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures. Biotechnol Bioeng. 2017 12; 114(12):2717-2728. PMID: 28710856.
      Citations: 9     Fields:    Translation:AnimalsCells
    36. Trunfio N, Lee H, Starkey J, Agarabi C, Liu J, Yoon S. Characterization of mammalian cell culture raw materials by combining spectroscopy and chemometrics. Biotechnol Prog. 2017 Jul; 33(4):1127-1138. PMID: 28393480.
      Citations: 4     Fields:    Translation:AnimalsCells
    37. Liu H, Galbraith SC, Ricart B, Stanton C, Smith-Goettler B, Verdi L, O'Connor T, Lee S, Yoon S. Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data. Int J Pharm. 2017 Jun 15; 525(1):249-263. PMID: 28450171.
      Citations: 12     Fields:    
    38. Bhatia H, Read E, Agarabi C, Brorson K, Lute S, Yoon S. Hybridoma cell-culture and glycan profile dataset at various bioreactor conditions. Data Brief. 2016 Dec; 9:676-678. PMID: 27790631.
      Citations:    
    39. Bhatia H, Read E, Agarabi C, Brorson K, Lute S, Yoon S. A design space exploration for control of Critical Quality Attributes of mAb. Int J Pharm. 2016 Oct 15; 512(1):242-252. PMID: 27575657.
      Citations: 5     Fields:    Translation:Animals
    40. Reimonn TM, Park SY, Agarabi CD, Brorson KA, Yoon S. Effect of amino acid supplementation on titer and glycosylation distribution in hybridoma cell cultures-Systems biology-based interpretation using genome-scale metabolic flux balance model and multivariate data analysis. Biotechnol Prog. 2016 09; 32(5):1163-1173. PMID: 27452371.
      Citations: 3     Fields:    Translation:AnimalsCells
    41. Sha S, Agarabi C, Brorson K, Lee DY, Yoon S. N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies. Trends Biotechnol. 2016 10; 34(10):835-846. PMID: 27016033.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    42. Bhoskar P, Belongia B, Smith R, Yoon S, Carter T, Xu J. Free light chain content in culture media reflects recombinant monoclonal antibody productivity and quality. Biotechnol Prog. 2013 Sep-Oct; 29(5):1131-9. PMID: 23798487.
      Citations: 8     Fields:    Translation:AnimalsCells
    43. Kamga MH, Woo Lee H, Liu J, Yoon S. Quantification of protein mixture in chromatographic separation using multi-wavelength UV spectra. Biotechnol Prog. 2013 May-Jun; 29(3):664-71. PMID: 23441030.
      Citations: 3     Fields:    Translation:Animals
    44. Lee HW, Lawton C, Na YJ, Yoon S. Robustness of chemometrics-based feature selection methods in early cancer detection and biomarker discovery. Stat Appl Genet Mol Biol. 2013 Mar 13; 12(2):207-23. PMID: 23502343.
      Citations: 2     Fields:    Translation:Humans
    45. Lee HW, Bawn A, Yoon S. Reproducibility, complementary measure of predictability for robustness improvement of multivariate calibration models via variable selections. Anal Chim Acta. 2012 Dec 13; 757:11-8. PMID: 23206391.
      Citations: 2     Fields:    
    46. Lee HW, Christie A, Xu J, Yoon S. Data fusion-based assessment of raw materials in mammalian cell culture. Biotechnol Bioeng. 2012 Nov; 109(11):2819-28. PMID: 22566239.
      Citations: 3     Fields:    Translation:AnimalsCells
    47. Lee HW, Christie A, Liu JJ, Yoon S. Estimation of raw material performance in mammalian cell culture using near infrared spectra combined with chemometrics approaches. Biotechnol Prog. 2012 May-Jun; 28(3):824-32. PMID: 22467629.
      Citations: 1     Fields:    Translation:Animals
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