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Seongkyu Yoon PhD

Title
InstitutionUniversity of Massachusetts Lowell
DepartmentChemical Engineering
AddressPerry Hall, Room 310
Lowell, MA 01854
Phone978-934-4741
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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Morris C, Madhavarao CN, Yoon S, Ashraf M. Single in-line biomass probe detects CHO cell growth by capacitance and bacterial contamination by conductivity in bioreactor. Biotechnol J. 2021 Sep 30; e2100126. PMID: 34591352.
      View in: PubMed
    2. Kuang B, Dhara VG, Hoang D, Jenkins J, Ladiwala P, Tan Y, Shaffer SA, Galbraith SC, Betenbaugh MJ, Yoon S. Identification of novel inhibitory metabolites and impact verification on growth and protein synthesis in mammalian cells. Metab Eng Commun. 2021 Dec; 13:e00182. PMID: 34522610.
      View in: PubMed
    3. Morris C, Lee YS, Yoon S. Adventitious agent detection methods in bio-pharmaceutical applications with a focus on viruses, bacteria, and mycoplasma. Curr Opin Biotechnol. 2021 Jul 26; 71:105-114. PMID: 34325176.
      View in: PubMed
    4. Hoang D, Galbraith S, Kuang B, Johnson A, Yoon S. Characterization of Chinese hamster ovary cell culture feed media precipitate. Biotechnol Prog. 2021 Jun 24; e3188. PMID: 34165891.
      View in: PubMed
    5. Graham RJ, Mohammad A, Liang G, Fu Q, Kuang B, Polanco A, Lee YS, Marcus RK, Yoon S. Effect of iron addition on mAb productivity and oxidative stress in CHO culture. Biotechnol Prog. 2021 Jun 09. PMID: 34106525.
      View in: PubMed
    6. Liu H, Meyer R, Flamm M, Wareham L, Metzger M, Tantuccio A, Yoon S. Optimization of Critical Quality Attributes in Tablet Film Coating and Design Space Determination Using Pilot-Scale Experimental Data. AAPS PharmSciTech. 2021 Jan 03; 22(1):17. PMID: 33389197.
      View in: PubMed
    7. Behere K, Yoon S. n-Layer BET adsorption isotherm modeling for multimeric Protein A ligand and its lifetime determination. J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Nov 18; 1162:122434. PMID: 33302227.
      View in: PubMed
    8. Huang Z, Galbraith SC, Cha B, Liu H, Park S, Flamm MH, Metzger M, Tantuccio A, Yoon S. Effects of process parameters on tablet critical quality attributes in continuous direct compression: a case study of integrating data-driven statistical models and mechanistic compaction models. Pharm Dev Technol. 2020 Aug 18; 1-12. PMID: 32808839.
      View in: PubMed
    9. Behere K, Yoon S. Chromatography bioseparation technologies and in-silico modelings for continuous production of biotherapeutics. J Chromatogr A. 2020 Jun 29; 1627:461376. PMID: 32823091.
      View in: PubMed
    10. Liu H, Rivnay B, Avery K, Myung JH, Kozak D, Landrau N, Nivorozhkin A, Ashraf M, Yoon S. Optimization of the manufacturing process of a complex amphotericin B liposomal formulation using quality by design approach. Int J Pharm. 2020 May 27; 585:119473. PMID: 32473373.
      View in: PubMed
    11. Sha S, Handelman G, Liu N, Xie D, Yoon S. At-line N-linked glycan profiling for monoclonal antibodies with advanced sample preparation and high-performance liquid chromatography. J Biosci Bioeng. 2020 May 18. PMID: 32439286.
      View in: PubMed
    12. Sha S, Handelman G, Agarabi C, Yoon S. A high-resolution measurement of nucleotide sugars by using ion-pair reverse chromatography and tandem columns. Anal Bioanal Chem. 2020 Apr 16. PMID: 32300845.
      View in: PubMed
    13. Polanco A, Kuang B, Yoon S. Bioprocess Technologies that Preserve the Quality of iPSCs. Trends Biotechnol. 2020 Oct; 38(10):1128-1140. PMID: 32941792.
      View in: PubMed
    14. Graham R, Bhatia H, Yoon S. Consequences of trace metal variability and supplementation on CHO cell culture performance: a review of key mechanisms and considerations. Biotechnol Bioeng. 2019 Aug 12. PMID: 31403183.
      View in: PubMed
    15. Cha B, Galbraith SC, Liu H, Park SY, Huang Z, O'Connor T, Lee S, Yoon S. A Thermodynamic Balance Model for Liquid Film Drying Kinetics of a Tablet Film Coating and Drying Process. AAPS PharmSciTech. 2019 Jun 03; 20(5):209. PMID: 31161386.
      View in: PubMed
    16. Soong YV, Liu N, Yoon S, Lawton C, Xie D. Cellular and metabolic engineering of oleaginous yeast Yarrowia lipolytica for bioconversion of hydrophobic substrates into high-value products. Eng Life Sci. 2019 Jun; 19(6):423-443. PMID: 32625020.
      View in: PubMed
    17. Behere K, Cha B, Yoon S. Protein a resin lifetime study: Evaluation of protein a resin performance with a model-based approach in continuous capture. Prep Biochem Biotechnol. 2018 Mar 16; 48(3):242-256. PMID: 29355458.
      View in: PubMed
    18. Park SY, Reimonn TM, Agarabi CD, Brorson KA, Yoon S. Metabolic responses and pathway changes of mammalian cells under different culture conditions with media supplementations. Biotechnol Prog. 2018 Feb 21. PMID: 29464928.
      View in: PubMed
    19. Sha S, Bhatia H, Yoon S. An RNA-seq based transcriptomic investigation into the productivity and growth variants with Chinese hamster ovary cells. J Biotechnol. 2018 Apr 10; 271:37-46. PMID: 29476805.
      View in: PubMed
    20. Liu H, Galbraith SC, Park SY, Cha B, Huang Z, Meyer RF, Flamm MH, O'Connor T, Lee S, Yoon S. Assessment of spatial heterogeneity in continuous twin screw wet granulation process using three-compartmental population balance model. Pharm Dev Technol. 2018 Jan 25; 1-13. PMID: 29336653.
      View in: PubMed
    21. Galbraith SC, Liu H, Cha B, Park SY, Huang Z, Yoon S. Modeling and simulation of continuous powder blending applied to a continuous direct compression process. Pharm Dev Technol. 2018 Jan 17; 1-11. PMID: 29304722.
      View in: PubMed
    22. Bhatia H, Mehdizadeh H, Drapeau D, Yoon S. In-line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics models. Eng Life Sci. 2018 Jan; 18(1):55-61. PMID: 32624861.
      View in: PubMed
    23. Huang Z, Lee DY, Yoon S. Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures. Biotechnol Bioeng. 2017 12; 114(12):2717-2728. PMID: 28710856.
      View in: PubMed
    24. Liu H, Galbraith SC, Ricart B, Stanton C, Smith-Goettler B, Verdi L, O'Connor T, Lee S, Yoon S. Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data. Int J Pharm. 2017 Jun 15; 525(1):249-263. PMID: 28450171.
      View in: PubMed
    25. Trunfio N, Lee H, Starkey J, Agarabi C, Liu J, Yoon S. Characterization of Mammalian Cell Culture Raw Materials by Combining Spectroscopy and Chemometrics. Biotechnol Prog. 2017 Apr 10. PMID: 28393480.
      View in: PubMed
    26. Bhatia H, Read E, Agarabi C, Brorson K, Lute S, Yoon S. Hybridoma cell-culture and glycan profile dataset at various bioreactor conditions. Data Brief. 2016 Dec; 9:676-678. PMID: 27790631.
      View in: PubMed
    27. Bhatia H, Read E, Agarabi C, Brorson K, Lute S, Yoon S. A design space exploration for control of Critical Quality Attributes of mAb. Int J Pharm. 2016 Oct 15; 512(1):242-52. PMID: 27575657.
      View in: PubMed
    28. Reimonn TM, Park SY, Agarabi CD, Brorson KA, Yoon S. Effect of amino acid supplementation on titer and glycosylation distribution in hybridoma cell cultures-Systems biology-based interpretation using genome-scale metabolic flux balance model and multivariate data analysis. Biotechnol Prog. 2016 Sep; 32(5):1163-1173. PMID: 27452371.
      View in: PubMed
    29. Sha S, Agarabi C, Brorson K, Lee DY, Yoon S. N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies. Trends Biotechnol. 2016 Oct; 34(10):835-46. PMID: 27016033.
      View in: PubMed
    30. Bhoskar P, Belongia B, Smith R, Yoon S, Carter T, Xu J. Free light chain content in culture media reflects recombinant monoclonal antibody productivity and quality. Biotechnol Prog. 2013 Sep-Oct; 29(5):1131-9. PMID: 23798487.
      View in: PubMed
    31. Kamga MH, Woo Lee H, Liu J, Yoon S. Quantification of protein mixture in chromatographic separation using multi-wavelength UV spectra. Biotechnol Prog. 2013 May-Jun; 29(3):664-71. PMID: 23441030.
      View in: PubMed
    32. Lee HW, Lawton C, Na YJ, Yoon S. Robustness of chemometrics-based feature selection methods in early cancer detection and biomarker discovery. Stat Appl Genet Mol Biol. 2013 May; 12(2):207-23. PMID: 23502343.
      View in: PubMed
    33. Lee HW, Bawn A, Yoon S. Reproducibility, complementary measure of predictability for robustness improvement of multivariate calibration models via variable selections. Anal Chim Acta. 2012 Dec 13; 757:11-8. PMID: 23206391.
      View in: PubMed
    34. Lee HW, Christie A, Xu J, Yoon S. Data fusion-based assessment of raw materials in mammalian cell culture. Biotechnol Bioeng. 2012 Nov; 109(11):2819-28. PMID: 22566239.
      View in: PubMed
    35. Lee HW, Christie A, Liu JJ, Yoon S. Estimation of raw material performance in mammalian cell culture using near infrared spectra combined with chemometrics approaches. Biotechnol Prog. 2012 May-Jun; 28(3):824-32. PMID: 22467629.
      View in: PubMed
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