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Jane B Lian PhD

TitleAdjunct Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentOrthopedics and Physical Rehabilitation
AddressUniversity of Vermont School of Medicine
89 Beaumont Ave
Burlington VT 05405
Phone802-656-4872
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentOrthopedics and Physical Rehabilitation

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBioinformatics and Computational Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCell Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology


    Collapse Biography 
    Collapse education and training
    Fordham University, Bronx, NY, United StatesBSChemistry
    University of Rochester, Rochester, NY, United StatesMSBiophysics
    Boston University School of Medicine, Boston, MA, United StatesPHDBiochemistry

    Collapse Overview 
    Collapse overview

    Academic Background

    Associate Professor of Biological Chemistry, Harvard Medical School, Boston

    Senior Research Associate, Department of Orthopaedic Surgery, Children's Hospital Medical Center, Boston

    Post-doctoral training: National Institutes of Health; Harvard Medical School, Children's Hospital.

    Ph.D., Boston University School of Medicine

    Molecular Mechanisms Regulating Skeletal Development and Metastasis of Cancer Cells to Bone

    Bone tissue functions as a mechanically responsive structural component of the body and as a major organ essential for maintaining calcium and phosphate homeostasis. The skeleton is the target of numerous human genetic disorders and recently mouse models have identified new regulatory pathways that affect the skeleton. As a normal process of aging and hormonal changes after the menopause, skeletal mass can decrease by as much as 30% leading to bone fracture and compromised quality of life in the elderly population. Historically the laboratory has addressed molecular mechanisms regulating formation and mineralization of bone by osteoblasts and turnover of bone tissue by osteoclasts, the bone resorbing cells. We are defining the key regulatory events for the progressive differentiation of osteoprogenitor stem cells to osteogenic cells by identifying transcription factor complexes that control expression of tissue-specific genes. Our studies are showing that early events of skeletal development are recapitulated in the adult skeleton for the normal maintenance of bone mass.

    The skeleton is also a target of metastatic cancers and recent studies from our laboratory and others are demonstrating that signaling pathways which mediate responsiveness of the bone forming and bone resorbing cells of the skeleton for organogenesis are also pathways that are activated in cancer cells which metastasize to bone.

    Areas of current investigation for graduate and MD/PhD students and postdoctoral fellows include:

    1.   Combinatorial Control Mechanisms for Skeletal Development

    This laboratory is defining a regulatory network of developmental factors with a focus on three major pathways critical for skeletal pattern formation, early embryonic bone development, and osteoblast differentiation:  the bone morphogenetic protein (BMP) family, the Wnt signaling pathway and Hox homeodomain factors.  The integration of these signaling pathways for tissue-specific gene expression is being characterized for two genes, the transcription factor Runx2/Cbfa1 established as essential for skeletal development and a bone-specific Runx2 target gene, osteocalcin, that represents one of the major non-collagenous bone matrix proteins (Choi et al., 2001; Lengner et al., 2002).  The Runx2/Cbfa transcription factor is essential for osteogenic differentiation and functions as a master regulatory gene through multiple properties (Fig. 1). Runx2 can change the phenotype of a cell, e.g., from a non-osseous adipocyte to an osteoblast, as well as control recruitment of stem cells into the chondrogenic and osteogenic phenotype (Lengner et al., 2005).  Characterizing the functional activities of this protein has provided new paradigms for understanding gene regulation.  First, Runx2 expression is regulated in stem cells by early development cues including Hox genes, BMP/TGFb, and Wnt proteins (Balint et al., 2003, Zaidi et al., 2002; Gaur et al., 2005, 2006; Bodine et al., 2004).  Secondly, this transcription factor is a scaffolding protein that is targeted to specific subnuclear domains for the assembly of multimeric complexes on target genes (reviewed in Lian et al., 2004).  Third, Runx2 recruits chromatin remodeling proteins and assembles complexes at Runx2 regulatory elements in genes to either activate or repress gene transcription (Javed et al., 1999; Young et al., 2005).  By mutational analyses of different protein interacting domains of Runx2, we are identifying the coregulatory proteins essential for osteoblast differentiation in vitro and for skeletal development in vivo (Zaidi et al., 2004; Afzal et al., 2005). Experimental approaches include cell culture models for chondrocyte and osteoblast differentiation using human embryonic and mesenchymal stem cells, gene regulation studies and characterization of mouse phenotypes. 

    2.  Tissue Specific Gene Regulatory Mechanisms

    The osteocalcin gene encodes a calcium binding ECM protein that is developmentally regulated during bone formation by a plethora of hormones, growth factors, and cell signaling proteins involved in calcium homeostasis and bone remodeling. The integration of independent signals must converge on the promoter to account for complex physiologic control of the gene during bone formation and turnover. Thus, the promoter of the osteocalcin gene provides a molecular blueprint for understanding developmental and hormonal regulation of gene expression required for bone formation (Hassan et al., 2004; Javed et al., 1999; Gutierrez et al., 2004). Identification of tissue-specific regulatory sequences and their cognate binding factors have allowed us to develop strategies for cell based therapy to target therapeutic genes specifically to bone. Examples of osteocalcin tissue-specific regulatory elements undergoing characterization include the steroid response elements, runt homology (Runx/Cbfa), homeodomain (HD), Hox, C/EBP, ATF and AP-1 protein binding sites.  The HD proteins (Msx, Dlx) and Hoxa10 regulate osteocalcin at different stages of cell differentiation (Fig. 2). Transcriptional control of the gene is evaluated at multiple levels including chromatin modifications and recruitment of transcription factors and their coregulatory proteins by chromatin immunoprecipitation studies.  Enforced expression and siRNA knockdown studies of regulatory factors strategies are used to establish their function in vitro and in vivo using transgenic mouse models. Such analyses have revealed new insights into understanding the complex interplay of physiologic mediators of tissue differentiation. This program of research provides a student with fundamental techniques requisite for characterizing gene regulation and expression in a biological context.

    3.  Cancer Cell Biology in the Bone Microenvironment

    The end stage of breast and prostate cancer is metastasis to bone, with very poor prognosis with nearly 70% mortality within a year.  Cancer cells cause destruction of the bone, resulting in fractures and severe pain.  Understanding the mechanisms which induce metastasis of the primary cancer cell to the bone environment needs to be addressed.  We have identified high expression levels of the Runx2 transcription factor in metastatic breast and prostate cancer cell lines.  Runx target genes in the cancer cell include the entire class of matrix metalloproteinases characterized for their role in tissue invasion, the vascular endothelial growth factor, a potent angiogenic factor involved as a primary event in tumor growth and several cell growth and osteoblastic genes expressed in the bone environment that allow for tumor growth (Fig. 3) (Pratap et al., 2005).  The cancer cell responds to TGFb and BMP growth factors in the bone extracellular matrix and stimulates bone resorbing cells.  In recent studies, we have shown metastatic cancer cell lines in which Runx2 activity has been blocked through genetic mutations, that the osteolytic disease of breast cancer cells can be prevented in the mouse (Barnes et al., 2004; Javed et al., 2005). The presence of mutant Runx2 protein in metastatic cells inhibits cell invasion (in vitro assays) and genes associated with tumor growth (Fig. 3).  We are now turning our attention to mechanisms responsible for activation of Runx2 in the primary tumor that would lead to the metastatic event in vivo.  Experimental approaches include generation of human cancer cell lines with mutants of Runx2, assessing tumor growth by in vivo imaging of tumors in breast, prostate and bone tissues, and examining gene expression profiles of the tumors are assayed.

    4.  Gene Therapy and Tissue Engineering for Skeletal Diseases

    Genetic disorders of the skeleton require expression of the normal proteins, specifically in bone cells.   Here the osteocalcin gene promoter provides the appropriate method for targeting expressed genes to mature osteoblasts.  Using OC-EGFP mice, we are characterizing a population of mesenchymal stem cells from these mice that differentiate into bone cells expressing GFP in donor mice.  Numerous donor mice carrying mutated genes that mimic human genetic disorders are available for addressing the critical number of mesenchymal stem cells differentiated to osteoblasts that can provide a sufficient level of normal protein to correct the skeletal disorder.  A second example where tissue engineering is being developed relates to the problem of non-union fractures where scar tissue rather than new bone formation occurs.  By using autologous cells expressing osteogenic factors, bone formation can be induced.  Lastly, we are culturing human embryonic stem cells and promoting their differentiation to chondrogenic and osteogenic lineages and testing these in mouse models.  These powerful properties are being exploited for treatment of skeletal diseases that require rebuilding of skeletal tissue by promoting lineage allocation of stem cells or marrow progenitor cells. 

    Figures

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      Lian Figure 1

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      Lian Figure 2
      

     Figure 3

     

      Lian Figure 3
      

     




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zaidi SK, Perez AW, White ES, Lian JB, Stein JL, Stein GS. An AML1-ETO/miR-29b-1 regulatory circuit modulates phenotypic properties of acute myeloid leukemia cells. Oncotarget. 2017 May 24. PMID: 28611288.
      View in: PubMed
    2. Wu Q, Lian JB, Stein JL, Stein GS, Nickerson JA, Imbalzano AN. The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer. Epigenomics. 2017 May 19. PMID: 28521512.
      View in: PubMed
    3. Fritz AJ, Ghule PN, Boyd JR, Tye CE, Page NA, Hong D, Weinheimer AS, Barutcu AR, Gerrard DL, Frietze S, Zaidi SK, Imbalzano A, Lian JB, Stein JL, Stein GS. Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer. J Cell Physiol. 2017 May 15. PMID: 28504305.
      View in: PubMed
    4. Tracy KM, Tye CE, Page NA, Fritz AJ, Stein JL, Lian JB, Stein GS. Selective expression of long non-coding RNAs in a breast cancer cell progression model. J Cell Physiol. 2017 May 10. PMID: 28488769.
      View in: PubMed
    5. Reagan MR, Lian J, Rosen CJ, Stein G. A Perspective on Malignancy in the Marrow. J Cell Physiol. 2017 Feb 16. PMID: 28206683.
      View in: PubMed
    6. VanOudenhove JJ, Grandy RA, Ghule PN, Lian JB, Stein JL, Zaidi SK, Stein GS. Unique Regulatory Mechanisms for the Human Embryonic Stem Cell Cycle. J Cell Physiol. 2017 Jun; 232(6):1254-1257. PMID: 27532275.
      View in: PubMed
    7. Wu H, Gordon JA, Whitfield TW, Tai PW, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Chromatin Dynamics Regulate Mesenchymal Stem Cell Lineage Specification and Differentiation to Osteogenesis. Biochim Biophys Acta. 2017 Jan 08. PMID: 28077316.
      View in: PubMed
    8. Barutcu AR, Lian JB, Stein JL, Stein GS, Imbalzano AN. The connection between BRG1, CTCF and topoisomerases at TAD boundaries. Nucleus. 2017 Jan 06; 1-6. PMID: 28060558.
      View in: PubMed
    9. Zaidi SK, Lian JB, van Wijnen A, Stein JL, Stein GS. Mitotic Gene Bookmarking: An Epigenetic Mechanism for Coordination of Lineage Commitment, Cell Identity and Cell Growth. Adv Exp Med Biol. 2017; 962:95-102. PMID: 28299653.
      View in: PubMed
    10. Zingiryan A, Farina NH, Finstad KH, Stein JL, Lian JB, Stein GS. Cover Image, Volume 232, Number 1, January 2017. J Cell Physiol. 2017 Jan; 232(1):i. PMID: 27643521.
      View in: PubMed
    11. Taipaleenmäki H, Farina NH, van Wijnen AJ, Stein JL, Hesse E, Stein GS, Lian JB. Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells. Oncotarget. 2016 Nov 29; 7(48):79032-79046. PMID: 27738322.
      View in: PubMed
    12. Farina NH, Zingiryan A, Akech JA, Callahan CJ, Lu H, Stein JL, Languino LR, Stein GS, Lian JB. A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice. Oncotarget. 2016 Oct 25; 7(43):70462-70474. PMID: 27634876.
      View in: PubMed
    13. VanOudenhove JJ, Medina R, Ghule PN, Lian JB, Stein JL, Zaidi SK, Stein GS. Transient RUNX1 Expression during Early Mesendodermal Differentiation of hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling. Stem Cell Reports. 2016 Nov 8; 7(5):884-896. PMID: 27720906.
      View in: PubMed
    14. Maeda Y, Farina NH, Matzelle MM, Fanning PJ, Lian JB, Gravallese EM. Synovium-Derived MicroRNAs Regulate Bone Pathways in Rheumatoid Arthritis. J Bone Miner Res. 2016 Sep 27. PMID: 27676131.
      View in: PubMed
    15. Dobson JR, Hong D, Barutcu AR, Wu H, Imbalzano AN, Lian JB, Stein JL, van Wijnen AJ, Nickerson JA, Stein GS. Identifying Nuclear Matrix-Attached DNA Across the Genome. J Cell Physiol. 2016 Sep 14. PMID: 27627025.
      View in: PubMed
    16. Ghule PN, Xie RL, Colby JL, Rivera-Pérez JA, Jones SN, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos. Dev Biol. 2016 Nov 15; 419(2):311-320. PMID: 27609454.
      View in: PubMed
    17. VanOudenhove JJ, Medina R, Ghule PN, Lian JB, Stein JL, Zaidi SK, Stein G. Precocious Phenotypic Transcription-Factor Expression During Early Development. J Cell Biochem. 2016 Sep 03. PMID: 27591551.
      View in: PubMed
    18. Del Mare S, Husanie H, Iancu O, Abu-Odeh M, Evangelou K, Lovat F, Volinia S, Gordon J, Amir G, Stein J, Stein GS, Croce CM, Gorgoulis V, Lian JB, Aqeilan RI. WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma. Cancer Res. 2016 Oct 15; 76(20):6107-6117. PMID: 27550453.
      View in: PubMed
    19. Barutcu AR, Hong D, Lajoie BR, McCord RP, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Imbalzano AN, Stein GS. RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells. Biochim Biophys Acta. 2016 Nov; 1859(11):1389-1397. PMID: 27514584.
      View in: PubMed
    20. Barutcu AR, Lajoie BR, Fritz AJ, McCord RP, Nickerson JA, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Stein GS, Imbalzano AN. SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells. Genome Res. 2016 Sep; 26(9):1188-201. PMID: 27435934.
      View in: PubMed
    21. Wu Q, Madany P, Dobson JR, Schnabl JM, Sharma S, Smith TC, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Muthuswami R, Imbalzano AN, Nickerson JA. The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation. Oncotarget. 2016 Jun 21; 7(25):38270-38281. PMID: 27223259.
      View in: PubMed
    22. Tasadduq R, Gordon J, Al-Ghanim KA, Lian JB, Van Wijnen AJ, Stein JL, Stein GS, Shakoori AR. Ethanol Extract of Cissus quadrangularis Enhances Osteoblast Differentiation and Mineralization of Murine Pre-Osteoblastic MC3T3-E1 Cells. J Cell Physiol. 2017 Mar; 232(3):540-547. PMID: 27264191.
      View in: PubMed
    23. Liu W, Wu M, Huang Z, Lian J, Chen J, Wang T, Leung AY, Liao Y, Zhang Z, Liu Q, Yen K, Lin S, Zon LI, Wen Z, Zhang Y, Zhang W. c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia. 2017 Jan; 31(1):222-233. PMID: 27457538.
      View in: PubMed
    24. Carr FE, Tai PW, Barnum MS, Gillis NE, Evans KG, Taber TH, White JH, Tomczak JA, Jaworski DM, Zaidi SK, Lian JB, Stein JL, Stein GS. Thyroid Hormone Receptor-ß (TRß) Mediates Runt-Related Transcription Factor 2 (Runx2) Expression in Thyroid Cancer Cells: A Novel Signaling Pathway in Thyroid Cancer. Endocrinology. 2016 Aug; 157(8):3278-92. PMID: 27253998.
      View in: PubMed
    25. Zheng L, Tu Q, Meng S, Zhang L, Yu L, Song J, Hu Y, Sui L, Zhang J, Dard M, Cheng J, Murray D, Tang Y, Lian JB, Stein GS, Chen J. Runx2/DICER/miRNA Pathway in Regulating Osteogenesis. J Cell Physiol. 2017 Jan; 232(1):182-91. PMID: 27064596.
      View in: PubMed
    26. Zingiryan A, Farina NH, Finstad KH, Stein JL, Lian JB, Stein GS. Dissection of Individual Prostate Lobes in Mouse Models of Prostate Cancer to Obtain High Quality RNA. J Cell Physiol. 2017 Jan; 232(1):14-8. PMID: 26992144.
      View in: PubMed
    27. Stein GS, Messier TL, Gordon JA, Boyd JR, Tye CE, Lian JB, Stein JL. Oncogenic epigenetic control. Aging (Albany NY). 2016 Apr; 8(4):565-6. PMID: 27038551.
      View in: PubMed
    28. Van Oudenhove JJ, Grandy RA, Ghule PN, Del Rio R, Lian JB, Stein JL, Zaidi SK, Stein GS. Lineage-Specific Early Differentiation of Human Embryonic Stem Cells Requires a G2 Cell Cycle Pause. Stem Cells. 2016 Jul; 34(7):1765-75. PMID: 26946228.
      View in: PubMed
    29. Messier TL, Boyd JR, Gordon JA, Stein JL, Lian JB, Stein GS. Oncofetal Epigenetic Bivalency in Breast Cancer Cells: H3K4 and H3K27 Tri-Methylation as a Biomarker for Phenotypic Plasticity. J Cell Physiol. 2016 Nov; 231(11):2474-81. PMID: 26916849.
      View in: PubMed
    30. Wang X, Lian J, Xu XJ, Li X, Li P, Li MM, Wang Y, Liu YX. Optimization of polarizer azimuth in improving signal-to-noise ratio in Kerr microscopy. Appl Opt. 2016 Mar 1; 55(7):1725-30. PMID: 26974636.
      View in: PubMed
    31. Zaidi SK, Boyd JR, Grandy RA, Medina R, Lian JB, Stein GS, Stein JL. Expression of Ribosomal RNA and Protein Genes in Human Embryonic Stem Cells Is Associated With the Activating H3K4me3 Histone Mark. J Cell Physiol. 2016 Sep; 231(9):2007-13. PMID: 26755341.
      View in: PubMed
    32. Messier TL, Gordon JA, Boyd JR, Tye CE, Browne G, Stein JL, Lian JB, Stein GS. Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes. Oncotarget. 2016 Feb 02; 7(5):5094-109. PMID: 26783963.
      View in: PubMed
    33. Browne G, Dragon JA, Hong D, Messier TL, Gordon JA, Farina NH, Boyd JR, VanOudenhove JJ, Perez AW, Zaidi SK, Stein JL, Stein GS, Lian JB. MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells. Tumour Biol. 2016 Jul; 37(7):8825-39. PMID: 26749280.
      View in: PubMed
    34. Barutcu AR, Fritz AJ, Zaidi SK, van Wijnen AJ, Lian JB, Stein JL, Nickerson JA, Imbalzano AN, Stein GS. C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization. J Cell Physiol. 2016 Jan; 231(1):31-5. PMID: 26059817.
      View in: PubMed
    35. Fritz AJ, Barutcu AR, Martin-Buley L, van Wijnen AJ, Zaidi SK, Imbalzano AN, Lian JB, Stein JL, Stein GS. Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus. J Cell Biochem. 2016 Jan; 117(1):9-19. PMID: 26192137.
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    36. Grandy RA, Whitfield TW, Wu H, Fitzgerald MP, VanOudenhove JJ, Zaidi SK, Montecino MA, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Genome-Wide Studies Reveal that H3K4me3 Modification in Bivalent Genes Is Dynamically Regulated during the Pluripotent Cell Cycle and Stabilized upon Differentiation. Mol Cell Biol. 2015 Dec 07; 36(4):615-27. PMID: 26644406.
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    37. Wu Q, Madany P, Akech J, Dobson JR, Douthwright S, Browne G, Colby JL, Winter GE, Bradner JE, Pratap J, Sluder G, Bhargava R, Chiosea SI, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Nickerson JA, Imbalzano AN. The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation. J Cell Physiol. 2015 Nov; 230(11):2683-94. PMID: 25808524.
      View in: PubMed
    38. Rojas A, Aguilar R, Henriquez B, Lian JB, Stein JL, Stein GS, van Wijnen AJ, van Zundert B, Allende ML, Montecino M. Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B. J Biol Chem. 2015 Nov 20; 290(47):28329-42. PMID: 26453309.
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    39. Xuan D, Han Q, Tu Q, Zhang L, Yu L, Murry D, Tu T, Tang Y, Lian JB, Stein GS, Valverde P, Zhang J, Chen J. Epigenetic Modulation in Periodontitis: Interaction of Adiponectin and JMJD3-IRF4 Axis in Macrophages. J Cell Physiol. 2016 May; 231(5):1090-6. PMID: 26399931.
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    40. Lim KE, Park NR, Che X, Han MS, Jeong JH, Kim SY, Park CY, Akiyama H, Kim JE, Ryoo HM, Stein JL, Lian JB, Stein GS, Choi JY. Core Binding Factor ß of Osteoblasts Maintains Cortical Bone Mass Via Stabilization of Runx2 in Mice. J Bone Miner Res. 2015 Oct; 30(10):1943. PMID: 26390980.
      View in: PubMed
    41. Browne G, Taipaleenmäki H, Bishop NM, Madasu SC, Shaw LM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Runx1 is associated with breast cancer progression in MMTV-PyMT transgenic mice and its depletion in vitro inhibits migration and invasion. J Cell Physiol. 2015 Oct; 230(10):2522-32. PMID: 25802202.
      View in: PubMed
    42. Barutcu AR, Lajoie BR, McCord RP, Tye CE, Hong D, Messier TL, Browne G, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Imbalzano AN, Stein GS. Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells. Genome Biol. 2015 Sep 28; 16:214. PMID: 26415882.
      View in: PubMed
    43. Zhang X, Wu H, Dobson JR, Browne G, Hong D, Akech J, Languino LR, Stein GS, Lian JB. Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFß1. J Cell Biochem. 2015 Sep; 116(9):2098-108. PMID: 25808168.
      View in: PubMed
    44. Lim KE, Park NR, Che X, Han MS, Jeong JH, Kim SY, Park CY, Akiyama H, Kim JE, Ryoo HM, Stein JL, Lian JB, Stein GS, Choi JY. Core Binding Factor ß of Osteoblasts Maintains Cortical Bone Mass via Stabilization of Runx2 in Mice. J Bone Miner Res. 2016 Jan; 31(1):245. PMID: 26804813.
      View in: PubMed
    45. Ghule PN, Xie RL, Colby JL, Jones SN, Lian JB, Wijnen AJ, Stein JL, Stein GS. p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency. Cell Cycle. 2015 Aug 3; 14(15):2501-8. PMID: 26030398.
      View in: PubMed
    46. Hassan MQ, Tye CE, Stein GS, Lian JB. Non-coding RNAs: Epigenetic regulators of bone development and homeostasis. Bone. 2015 Dec; 81:746-56. PMID: 26039869.
      View in: PubMed
    47. Lian JB. Epigenetic pathways regulating bone homeostasis. Bone. 2015 Dec; 81:731-2. PMID: 26036171.
      View in: PubMed
    48. Trombly DJ, Whitfield TW, Padmanabhan S, Gordon JA, Lian JB, van Wijnen AJ, Zaidi SK, Stein JL, Stein GS. Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells. BMC Genomics. 2015 Apr 17; 16:309. PMID: 25928846.
      View in: PubMed
    49. Lim KE, Park NR, Che X, Han MS, Jeong JH, Kim SY, Park CY, Akiyama H, Kim JE, Ryoo HM, Stein JL, Lian JB, Stein GS, Choi JY. Core binding factor ß of osteoblasts maintains cortical bone mass via stabilization of Runx2 in mice. J Bone Miner Res. 2015 Apr; 30(4):715-22. PMID: 25358268.
      View in: PubMed
    50. Tye CE, Gordon JA, Martin-Buley LA, Stein JL, Lian JB, Stein GS. Could lncRNAs be the missing links in control of mesenchymal stem cell differentiation? J Cell Physiol. 2015 Mar; 230(3):526-34. PMID: 25258250.
      View in: PubMed
    51. LeBlanc KT, Walcott ME, Gaur T, O'Connell SL, Basil K, Tadiri CP, Mason-Savas A, Silva JA, van Wijnen AJ, Stein JL, Stein GS, Ayers DC, Lian JB, Fanning PJ. Runx1 Activities in Superficial Zone Chondrocytes, Osteoarthritic Chondrocyte Clones and Response to Mechanical Loading. J Cell Physiol. 2015 Feb; 230(2):440-8. PMID: 25078095.
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    52. Taipaleenmäki H, Browne G, Akech J, Zustin J, van Wijnen AJ, Stein JL, Hesse E, Stein GS, Lian JB. Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease. Cancer Res. 2015 Apr 1; 75(7):1433-44. PMID: 25634212.
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    53. Yang S, Quaresma AJ, Nickerson JA, Green KM, Shaffer SA, Imbalzano AN, Martin-Buley LA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response. J Cell Sci. 2015 Feb 15; 128(4):728-40. PMID: 25609707.
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    54. Kapinas K, Kim H, Mandeville M, Martin-Buley LA, Croce CM, Lian JB, van Wijnen AJ, Stein JL, Altieri DC, Stein GS. microRNA-mediated survivin control of pluripotency. J Cell Physiol. 2015 Jan; 230(1):63-70. PMID: 24891298.
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    55. Lopez-Camacho C, van Wijnen AJ, Lian JB, Stein JL, Stein GS. CBFß and the leukemogenic fusion protein CBFß-SMMHC associate with mitotic chromosomes to epigenetically regulate ribosomal genes. J Cell Biochem. 2014 Dec; 115(12):2155-64. PMID: 25079347.
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    56. Gordon JA, Montecino MA, Aqeilan RI, Stein JL, Stein GS, Lian JB. Epigenetic pathways regulating bone homeostasis: potential targeting for intervention of skeletal disorders. Curr Osteoporos Rep. 2014 Dec; 12(4):496-506. PMID: 25260661.
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    57. Gordon JA, Lisle JW, Alman BA, Lian JB. Disruption of crosstalk between mesenchymal stromal and tumor cells in bone marrow as a therapeutic target to prevent metastatic bone disease. J Cell Physiol. 2014 Dec; 229(12):1884-6. PMID: 24905746.
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    58. Aguilar R, Grandy R, Meza D, Sepulveda H, Pihan P, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M. A functional N-terminal domain in C/EBPß-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts. J Cell Physiol. 2014 Oct; 229(10):1521-8. PMID: 24585571.
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    59. Lopez-Camacho C, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Core binding factor ß (CBFß) is retained in the midbody during cytokinesis. J Cell Physiol. 2014 Oct; 229(10):1466-74. PMID: 24648201.
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    60. Barutcu AR, Tai PW, Wu H, Gordon JA, Whitfield TW, Dobson JR, Imbalzano AN, Lian JB, van Wijnen AJ, Stein JL, Stein GS. The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter. Nucleic Acids Res. 2014; 42(16):10360-72. PMID: 25120271.
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    61. Zhang X, Akech J, Browne G, Russell S, Wixted JJ, Stein JL, Stein GS, Lian JB. Runx2-Smad signaling impacts the progression of tumor-induced bone disease. Int J Cancer. 2015 Mar 15; 136(6):1321-32. PMID: 25053011.
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    62. Dobson JR, Taipaleenmäki H, Hu YJ, Hong D, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Pratap J. hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3. Cancer Cell Int. 2014; 14:73. PMID: 25120384.
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    67. Tai PW, Zaidi SK, Wu H, Grandy RA, Montecino M, van Wijnen AJ, Lian JB, Stein GS, Stein JL. The dynamic architectural and epigenetic nuclear landscape: developing the genomic almanac of biology and disease. J Cell Physiol. 2014 Jun; 229(6):711-27. PMID: 24242872.
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    68. Browne G, Taipaleenmäki H, Stein GS, Stein JL, Lian JB. MicroRNAs in the control of metastatic bone disease. Trends Endocrinol Metab. 2014 Jun; 25(6):320-7. PMID: 24811921.
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    69. Farina NH, Wood ME, Perrapato SD, Francklyn CS, Stein GS, Stein JL, Lian JB. Standardizing analysis of circulating microRNA: clinical and biological relevance. J Cell Biochem. 2014 May; 115(5):805-11. PMID: 24357537.
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    70. Wu H, Whitfield TW, Gordon JA, Dobson JR, Tai PW, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis. Genome Biol. 2014 Mar 21; 15(3):R52. PMID: 24655370.
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    71. Zaidi SK, Grandy RA, Lopez-Camacho C, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Bookmarking target genes in mitosis: a shared epigenetic trait of phenotypic transcription factors and oncogenes? Cancer Res. 2014 Jan 15; 74(2):420-5. PMID: 24408924.
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    72. Dutta A, Li J, Lu H, Akech J, Pratap J, Wang T, Zerlanko BJ, FitzGerald TJ, Jiang Z, Birbe R, Wixted J, Violette SM, Stein JL, Stein GS, Lian JB, Languino LR. Integrin avß6 promotes an osteolytic program in cancer cells by upregulating MMP2. Cancer Res. 2014 Mar 1; 74(5):1598-608. PMID: 24385215.
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    73. Yoon WJ, Islam R, Cho YD, Woo KM, Baek JH, Uchida T, Komori T, van Wijnen A, Stein JL, Lian JB, Stein GS, Choi JY, Bae SC, Ryoo HM. Pin1-mediated Runx2 modification is critical for skeletal development. J Cell Physiol. 2013 Dec; 228(12):2377-85. PMID: 23702614.
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    75. Lian JB, Gordon JA, Stein GS. Redefining the activity of a bone-specific transcription factor: novel insights for understanding bone formation. J Bone Miner Res. 2013 Oct; 28(10):2060-3. PMID: 23966343.
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    76. Pande S, Browne G, Padmanabhan S, Zaidi SK, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells. J Cell Physiol. 2013 Aug; 228(8):1784-92. PMID: 23389849.
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    77. Abdeen SK, Del Mare S, Hussain S, Abu-Remaileh M, Salah Z, Hagan J, Rawahneh M, Pu XA, Russell S, Stein JL, Stein GS, Lian JB, Aqeilan RI. Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype. J Cell Physiol. 2013 Jul; 228(7):1377-82. PMID: 23254685.
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    78. Dowdy CR, Frederick D, Zaidi SK, Colby JL, Lian JB, van Wijnen AJ, Gerstein RM, Stein JL, Stein GS. A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation. Exp Hematol. 2013 Nov; 41(11):980-991.e1. PMID: 23823022.
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    79. Brown C, Burslem DF, Illian JB, Bao L, Brockelman W, Cao M, Chang LW, Dattaraja HS, Davies S, Gunatilleke CV, Gunatilleke IA, Huang J, Kassim AR, Lafrankie JV, Lian J, Lin L, Ma K, Mi X, Nathalang A, Noor S, Ong P, Sukumar R, Su SH, Sun IF, Suresh HS, Tan S, Thompson J, Uriarte M, Valencia R, Yap SL, Ye W, Law R. Multispecies coexistence of trees in tropical forests: spatial signals of topographic niche differentiation increase with environmental heterogeneity. Proc Biol Sci. 2013 Aug 7; 280(1764):20130502. PMID: 23782876.
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    80. van Wijnen AJ, van de Peppel J, van Leeuwen JP, Lian JB, Stein GS, Westendorf JJ, Oursler MJ, Im HJ, Taipaleenmäki H, Hesse E, Riester S, Kakar S. MicroRNA functions in osteogenesis and dysfunctions in osteoporosis. Curr Osteoporos Rep. 2013 Jun; 11(2):72-82. PMID: 23605904.
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    81. van der Deen M, Taipaleenmäki H, Zhang Y, Teplyuk NM, Gupta A, Cinghu S, Shogren K, Maran A, Yaszemski MJ, Ling L, Cool SM, Leong DT, Dierkes C, Zustin J, Salto-Tellez M, Ito Y, Bae SC, Zielenska M, Squire JA, Lian JB, Stein JL, Zambetti GP, Jones SN, Galindo M, Hesse E, Stein GS, van Wijnen AJ. MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. J Biol Chem. 2013 Jul 19; 288(29):21307-19. PMID: 23720736.
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    82. Tian H, Cao YX, Zhang XS, Liao WP, Yi YH, Lian J, Liu L, Huang HL, Liu WJ, Yin MM, Liang M, Shan G, Sun F. The targeting and functions of miRNA-383 are mediated by FMRP during spermatogenesis. Cell Death Dis. 2013; 4:e617. PMID: 23640459.
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    83. Duverger O, Isaac J, Zah A, Hwang J, Berdal A, Lian JB, Morasso MI. In vivo impact of Dlx3 conditional inactivation in neural crest-derived craniofacial bones. J Cell Physiol. 2013 Mar; 228(3):654-64. PMID: 22886599.
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    84. Cheng P, Ni Z, Dai X, Wang B, Ding W, Rae Smith A, Xu L, Wu D, He F, Lian J. The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. Cell Death Dis. 2013 Feb 07; 4:e489. PMID: 23392177.
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    85. Hovhannisyan H, Zhang Y, Hassan MQ, Wu H, Glackin C, Lian JB, Stein JL, Montecino M, Stein GS, van Wijnen AJ. Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene. J Cell Physiol. 2013 Feb; 228(2):313-21. PMID: 22886425.
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    86. McGee-Lawrence ME, Li X, Bledsoe KL, Wu H, Hawse JR, Subramaniam M, Razidlo DF, Stensgard BA, Stein GS, van Wijnen AJ, Lian JB, Hsu W, Westendorf JJ. Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice. J Biol Chem. 2013 Feb 22; 288(8):5291-302. PMID: 23300083.
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    87. Kapinas K, Grandy R, Ghule P, Medina R, Becker K, Pardee A, Zaidi SK, Lian J, Stein J, van Wijnen A, Stein G. The abbreviated pluripotent cell cycle. J Cell Physiol. 2013 Jan; 228(1):9-20. PMID: 22552993.
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    88. Browne G, Nesbitt H, Ming L, Stein GS, Lian JB, McKeown SR, Worthington J. Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistance. Br J Cancer. 2012 Nov 6; 107(10):1714-21. PMID: 23073173.
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    89. Hassan MQ, Maeda Y, Taipaleenmaki H, Zhang W, Jafferji M, Gordon JA, Li Z, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells. J Biol Chem. 2012 Dec 7; 287(50):42084-92. PMID: 23060446.
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    90. Tandon M, Gokul K, Ali SA, Chen Z, Lian J, Stein GS, Pratap J. Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells. Mol Cancer. 2012 Jun 18; 11:27. PMID: 22537242.
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    91. Zaidi SK, Trombly DJ, Dowdy CR, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Epigenetic mechanisms in leukemia. Adv Biol Regul. 2012 Sep; 52(3):369-76. PMID: 22884030.
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    92. Matzelle MM, Gallant MA, Condon KW, Walsh NC, Manning CA, Stein GS, Lian JB, Burr DB, Gravallese EM. Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway. Arthritis Rheum. 2012 May; 64(5):1540-50. PMID: 22139865.
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    93. Zhang Y, Xie RL, Gordon J, LeBlanc K, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2. J Biol Chem. 2012 Jun 22; 287(26):21926-35. PMID: 22544738.
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    94. Garlick DS, Li J, Sansoucy B, Wang T, Griffith L, Fitzgerald T, Butterfield J, Charbonneau B, Violette SM, Weinreb PH, Ratliff TL, Liao CP, Roy-Burman P, Vietri M, Lian JB, Stein GS, Altieri DC, Languino LR. a(V)ß(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma. Am J Transl Res. 2012; 4(2):165-74. PMID: 22611469.
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    95. Ali SA, Dobson JR, Lian JB, Stein JL, van Wijnen AJ, Zaidi SK, Stein GS. A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation. J Cell Sci. 2012 Jun 1; 125(Pt 11):2732-9. PMID: 22393235.
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    96. Gundberg CM, Lian JB, Booth SL. Vitamin K-dependent carboxylation of osteocalcin: friend or foe? Adv Nutr. 2012 Mar 01; 3(2):149-57. PMID: 22516722.
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    97. Jones KB, Salah Z, Del Mare S, Galasso M, Gaudio E, Nuovo GJ, Lovat F, LeBlanc K, Palatini J, Randall RL, Volinia S, Stein GS, Croce CM, Lian JB, Aqeilan RI. miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res. 2012 Apr 1; 72(7):1865-77. PMID: 22350417.
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    98. Duverger O, Zah A, Isaac J, Sun HW, Bartels AK, Lian JB, Berdal A, Hwang J, Morasso MI. Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of Dspp. J Biol Chem. 2012 Apr 6; 287(15):12230-40. PMID: 22351765.
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    99. Xu X, Xia J, Yang X, Huang X, Gao D, Zhou J, Lian J, Zhou J. Intermediate-conductance Ca(2+) -activated potassium and volume-sensitive chloride channels in endothelial progenitor cells from rat bone marrow mononuclear cells. Acta Physiol (Oxf). 2012 Jun; 205(2):302-13. PMID: 22168445.
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    100. Lian JB, Stein GS, van Wijnen AJ, Stein JL, Hassan MQ, Gaur T, Zhang Y. MicroRNA control of bone formation and homeostasis. Nat Rev Endocrinol. 2012 Jan 31; 8(4):212-27. PMID: 22290358.
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    101. Stein GS, Stein JL, van J Wijnen A, Lian JB, Montecino M, Medina R, Kapinas K, Ghule P, Grandy R, Zaidi SK, Becker KA. The architectural organization of human stem cell cycle regulatory machinery. Curr Pharm Des. 2012; 18(13):1679-85. PMID: 22394165.
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    102. van der Deen M, Akech J, Lapointe D, Gupta S, Young DW, Montecino MA, Galindo M, Lian JB, Stein JL, Stein GS, van Wijnen AJ. Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility. J Biol Chem. 2012 Feb 10; 287(7):4503-17. PMID: 22158627.
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    103. Lian J, Chen S, Zhang Y, Yao L. Gastroparesis following endoscopic submucosal dissection for early gastric cancer. Endoscopy. 2011; 43 Suppl 2 UCTN:E369. PMID: 22068650.
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    104. Henriquez B, Hepp M, Merino P, Sepulveda H, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M. C/EBPß binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells. J Cell Physiol. 2011 Nov; 226(11):3043-52. PMID: 21302301.
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    105. Khosla S, Bellido TM, Drezner MK, Gordon CM, Harris TB, Kiel DP, Kream BE, LeBoff MS, Lian JB, Peterson CA, Rosen CJ, Williams JP, Winer KK, Sherman SS. Forum on aging and skeletal health: summary of the proceedings of an ASBMR workshop. J Bone Miner Res. 2011 Nov; 26(11):2565-78. PMID: 21915901.
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    106. Altieri DC, Stein GS, Lian JB, Languino LR. TRAP-1, the mitochondrial Hsp90. Biochim Biophys Acta. 2012 Mar; 1823(3):767-73. PMID: 21878357.
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    107. Zhang J, Tu Q, Bonewald LF, He X, Stein G, Lian J, Chen J. Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1. J Bone Miner Res. 2011 Aug; 26(8):1953-63. PMID: 21351149.
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    108. Wang T, Languino LR, Lian J, Stein G, Blute M, Fitzgerald TJ. Molecular targets for radiation oncology in prostate cancer. Front Oncol. 2011; 1:17. PMID: 22645712.
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    109. Liu JC, Lengner CJ, Gaur T, Lou Y, Hussain S, Jones MD, Borodic B, Colby JL, Steinman HA, van Wijnen AJ, Stein JL, Jones SN, Stein GS, Lian JB. Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation. J Biol Chem. 2011 Aug 26; 286(34):30057-70. PMID: 21676869.
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    110. Zhang Y, Xie RL, Croce CM, Stein JL, Lian JB, van Wijnen AJ, Stein GS. A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9863-8. PMID: 21628588.
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    111. Gordon JA, Hassan MQ, Koss M, Montecino M, Selleri L, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex. Cells Tissues Organs. 2011; 194(2-4):146-50. PMID: 21597276.
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    112. Liu LJ, Xie R, Hussain S, Lian JB, Rivera-Perez J, Jones SN, Stein JL, Stein GS, van Wijnen AJ. Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development. Gene. 2011 Sep 1; 483(1-2):1-10. PMID: 21605641.
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    113. Ghule PN, Medina R, Lengner CJ, Mandeville M, Qiao M, Dominski Z, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Reprogramming the pluripotent cell cycle: restoration of an abbreviated G1 phase in human induced pluripotent stem (iPS) cells. J Cell Physiol. 2011 May; 226(5):1149-56. PMID: 20945438.
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    114. Pockwinse SM, Kota KP, Quaresma AJ, Imbalzano AN, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Nickerson JA. Live cell imaging of the cancer-related transcription factor RUNX2 during mitotic progression. J Cell Physiol. 2011 May; 226(5):1383-9. PMID: 20945391.
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    115. Hawse JR, Cicek M, Grygo SB, Bruinsma ES, Rajamannan NM, van Wijnen AJ, Lian JB, Stein GS, Oursler MJ, Subramaniam M, Spelsberg TC. TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts. PLoS One. 2011 Apr 29; 6(4):e19429. PMID: 21559363.
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    116. Del Mare S, Kurek KC, Stein GS, Lian JB, Aqeilan RI. Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma. Am J Cancer Res. 2011; 1(5):585-94. PMID: 21731849.
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    117. Zaidi SK, Young DW, Montecino M, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Bookmarking the genome: maintenance of epigenetic information. J Biol Chem. 2011 May 27; 286(21):18355-61. PMID: 21454629.
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    118. Kang BH, Tavecchio M, Goel HL, Hsieh CC, Garlick DS, Raskett CM, Lian JB, Stein GS, Languino LR, Altieri DC. Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease. Br J Cancer. 2011 Feb 15; 104(4):629-34. PMID: 21285984.
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    119. McGee-Lawrence ME, McCleary-Wheeler AL, Secreto FJ, Razidlo DF, Zhang M, Stensgard BA, Li X, Stein GS, Lian JB, Westendorf JJ. Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts. Bone. 2011 May 1; 48(5):1117-26. PMID: 21255693.
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    121. Pratap J, Akech J, Wixted JJ, Szabo G, Hussain S, McGee-Lawrence ME, Li X, Bedard K, Dhillon RJ, van Wijnen AJ, Stein JL, Stein GS, Westendorf JJ, Lian JB. The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss. Mol Cancer Ther. 2010 Dec; 9(12):3210-20. PMID: 21159607.
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    122. Lian J, Tian H, Liu L, Zhang XS, Li WQ, Deng YM, Yao GD, Yin MM, Sun F. Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1. Cell Death Dis. 2010; 1:e94. PMID: 21368870.
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    123. Bakshi R, Hassan MQ, Pratap J, Lian JB, Montecino MA, van Wijnen AJ, Stein JL, Imbalzano AN, Stein GS. The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes. J Cell Physiol. 2010 Nov; 225(2):569-76. PMID: 20506188.
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    124. Leong DT, Lim J, Goh X, Pratap J, Pereira BP, Kwok HS, Nathan SS, Dobson JR, Lian JB, Ito Y, Voorhoeve PM, Stein GS, Salto-Tellez M, Cool SM, van Wijnen AJ. Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility. Breast Cancer Res. 2010; 12(5):R89. PMID: 21029421.
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    125. Hassan MQ, Gordon JA, Beloti MM, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):19879-84. PMID: 20980664.
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    126. Kang BH, Siegelin MD, Plescia J, Raskett CM, Garlick DS, Dohi T, Lian JB, Stein GS, Languino LR, Altieri DC. Preclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancer. Clin Cancer Res. 2010 Oct 1; 16(19):4779-88. PMID: 20876793.
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    127. Jones MD, Liu JC, Barthel TK, Hussain S, Lovria E, Cheng D, Schoonmaker JA, Mulay S, Ayers DC, Bouxsein ML, Stein GS, Mukherjee S, Lian JB. A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes. Clin Cancer Res. 2010 Oct 15; 16(20):4978-89. PMID: 20843837.
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    128. Wixted JJ, Fanning P, Rothkopf I, Stein G, Lian J. Arachidonic acid, eicosanoids, and fracture repair. J Orthop Trauma. 2010 Sep; 24(9):539-42. PMID: 20736790.
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    129. Zaidi SK, Young DW, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information. Mol Cell Biol. 2010 Oct; 30(20):4758-66. PMID: 20696837.
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    130. Julg B, Pereyra F, Buzón MJ, Piechocka-Trocha A, Clark MJ, Baker BM, Lian J, Miura T, Martinez-Picado J, Addo MM, Walker BD. Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers. Clin Infect Dis. 2010 Jul 15; 51(2):233-8. PMID: 20550452.
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    131. Zaidi SK, Young DW, Montecino MA, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Mitotic bookmarking of genes: a novel dimension to epigenetic control. Nat Rev Genet. 2010 Aug; 11(8):583-9. PMID: 20628351.
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    132. Hassan MQ, Gordon JA, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Ribonucleoprotein immunoprecipitation (RNP-IP): a direct in vivo analysis of microRNA-targets. J Cell Biochem. 2010 Jul 1; 110(4):817-22. PMID: 20564179.
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    133. Lian J, Wu X, He F, Karnak D, Tang W, Meng Y, Xiang D, Ji M, Lawrence TS, Xu L. A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ. 2011 Jan; 18(1):60-71. PMID: 20577262.
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    134. Kurek KC, Del Mare S, Salah Z, Abdeen S, Sadiq H, Lee SH, Gaudio E, Zanesi N, Jones KB, DeYoung B, Amir G, Gebhardt M, Warman M, Stein GS, Stein JL, Lian JB, Aqeilan RI. Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. Cancer Res. 2010 Jul 1; 70(13):5577-86. PMID: 20530675.
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    135. Pratap J, Lian JB, Stein GS. Metastatic bone disease: role of transcription factors and future targets. Bone. 2011 Jan; 48(1):30-6. PMID: 20561908.
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    136. Gordon JA, Hassan MQ, Saini S, Montecino M, van Wijnen AJ, Stein GS, Stein JL, Lian JB. Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors. Mol Cell Biol. 2010 Jul; 30(14):3531-41. PMID: 20439491.
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    137. Han MS, Kim HJ, Wee HJ, Lim KE, Park NR, Bae SC, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Choi JY. The cleidocranial dysplasia-related R131G mutation in the Runt-related transcription factor RUNX2 disrupts binding to DNA but not CBF-beta. J Cell Biochem. 2010 May; 110(1):97-103. PMID: 20225274.
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    138. Jeong JH, Jung YK, Kim HJ, Jin JS, Kim HN, Kang SM, Kim SY, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Kato S, Choi JY. The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues. Mol Cell Biol. 2010 May; 30(10):2365-75. PMID: 20231365.
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    139. van der Deen M, Akech J, Wang T, FitzGerald TJ, Altieri DC, Languino LR, Lian JB, van Wijnen AJ, Stein JL, Stein GS. The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells. J Cell Biochem. 2010 Mar 1; 109(4):828-37. PMID: 20082326.
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    140. Arriagada G, Henriquez B, Moena D, Merino P, Ruiz-Tagle C, Lian JB, Stein GS, Stein JL, Montecino M. Recruitment and subnuclear distribution of the regulatory machinery during 1alpha,25-dihydroxy vitamin D3-mediated transcriptional upregulation in osteoblasts. J Steroid Biochem Mol Biol. 2010 Jul; 121(1-2):156-8. PMID: 20171279.
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    141. Ali SA, Zaidi SK, Dobson JR, Shakoori AR, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4165-9. PMID: 20160071.
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    142. Arriagada G, Paredes R, van Wijnen AJ, Lian JB, van Zundert B, Stein GS, Stein JL, Montecino M. 1alpha,25-dihydroxy vitamin D(3) induces nuclear matrix association of the 1alpha,25-dihydroxy vitamin D(3) receptor in osteoblasts independently of its ability to bind DNA. J Cell Physiol. 2010 Feb; 222(2):336-46. PMID: 19885846.
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    143. Becker KA, Ghule PN, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells. J Cell Physiol. 2010 Feb; 222(2):456-64. PMID: 19890848.
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    144. Gaur T, Hussain S, Mudhasani R, Parulkar I, Colby JL, Frederick D, Kream BE, van Wijnen AJ, Stein JL, Stein GS, Jones SN, Lian JB. Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse. Dev Biol. 2010 Apr 1; 340(1):10-21. PMID: 20079730.
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    145. Stein GS, van Wijnen AJ, Imbalzano AN, Montecino M, Zaidi SK, Lian JB, Nickerson JA, Stein JL. Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments. Crit Rev Eukaryot Gene Expr. 2010; 20(2):149-55. PMID: 21133844.
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    146. Zaidi SK, Medina RF, Pockwinse SM, Bakshi R, Kota KP, Ali SA, Young DW, Nickerson JA, Javed A, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Subnuclear localization and intranuclear trafficking of transcription factors. Methods Mol Biol. 2010; 647:77-93. PMID: 20694661.
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    147. Becker KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Human embryonic stem cells are pre-mitotically committed to self-renewal and acquire a lengthened G1 phase upon lineage programming. J Cell Physiol. 2010 Jan; 222(1):103-10. PMID: 19774559.
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    148. Dowdy CR, Xie R, Frederick D, Hussain S, Zaidi SK, Vradii D, Javed A, Li X, Jones SN, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation. Hum Mol Genet. 2010 Mar 15; 19(6):1048-57. PMID: 20035012.
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    149. San Martin IA, Varela N, Gaete M, Villegas K, Osorio M, Tapia JC, Antonelli M, Mancilla EE, Pereira BP, Nathan SS, Lian JB, Stein JL, Stein GS, van Wijnen AJ, Galindo M. Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells. J Cell Physiol. 2009 Dec; 221(3):560-71. PMID: 19739101.
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    150. Akech J, Wixted JJ, Bedard K, van der Deen M, Hussain S, Guise TA, van Wijnen AJ, Stein JL, Languino LR, Altieri DC, Pratap J, Keller E, Stein GS, Lian JB. Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions. Oncogene. 2010 Feb 11; 29(6):811-21. PMID: 19915614.
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    151. Stein GS, Stein JL, Van Wijnen AJ, Lian JB, Montecino M, Croce CM, Choi JY, Ali SA, Pande S, Hassan MQ, Zaidi SK, Young DW. Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer. Adv Enzyme Regul. 2010; 50(1):160-7. PMID: 19896493.
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    152. Zhang Y, Lian JB, Stein JL, van Wijnen AJ, Stein GS. The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells. J Cell Biochem. 2009 Oct 15; 108(3):651-9. PMID: 19670267.
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    153. Zaidi SK, Dowdy CR, van Wijnen AJ, Lian JB, Raza A, Stein JL, Croce CM, Stein GS. Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. Cancer Res. 2009 Nov 1; 69(21):8249-55. PMID: 19826043.
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    154. Xu J, Li X, Lian JB, Ayers DC, Song J. Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute. J Orthop Res. 2009 Oct; 27(10):1306-11. PMID: 19350632.
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    155. Wixted JJ, Fanning PJ, Gaur T, O'Connell SL, Silva J, Mason-Savas A, Ayers DC, Stein GS, Lian JB. Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor. J Cell Physiol. 2009 Oct; 221(1):31-9. PMID: 19544365.
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    156. Filion TM, Qiao M, Ghule PN, Mandeville M, van Wijnen AJ, Stein JL, Lian JB, Altieri DC, Stein GS. Survival responses of human embryonic stem cells to DNA damage. J Cell Physiol. 2009 Sep; 220(3):586-92. PMID: 19373864.
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    157. Pratap J, Imbalzano KM, Underwood JM, Cohet N, Gokul K, Akech J, van Wijnen AJ, Stein JL, Imbalzano AN, Nickerson JA, Lian JB, Stein GS. Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression. Cancer Res. 2009 Sep 1; 69(17):6807-14. PMID: 19690135.
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    158. Cruzat F, Henriquez B, Villagra A, Hepp M, Lian JB, van Wijnen AJ, Stein JL, Imbalzano AN, Stein GS, Montecino M. SWI/SNF-independent nuclease hypersensitivity and an increased level of histone acetylation at the P1 promoter accompany active transcription of the bone master gene Runx2. Biochemistry. 2009 Aug 4; 48(30):7287-95. PMID: 19545172.
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    159. Altieri DC, Languino LR, Lian JB, Stein JL, Leav I, van Wijnen AJ, Jiang Z, Stein GS. Prostate cancer regulatory networks. J Cell Biochem. 2009 Aug 1; 107(5):845-52. PMID: 19492418.
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    160. Xie R, Medina R, Zhang Y, Hussain S, Colby J, Ghule P, Sundararajan S, Keeler M, Liu LJ, van der Deen M, Mitra P, Lian JB, Rivera-Perez JA, Jones SN, Stein JL, van Wijnen AJ, Stein GS. The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12359-64. PMID: 19590016.
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    161. Gaur T, Wixted JJ, Hussain S, O'Connell SL, Morgan EF, Ayers DC, Komm BS, Bodine PV, Stein GS, Lian JB. Secreted frizzled related protein 1 is a target to improve fracture healing. J Cell Physiol. 2009 Jul; 220(1):174-81. PMID: 19301255.
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    162. Ghule PN, Dominski Z, Lian JB, Stein JL, van Wijnen AJ, Stein GS. The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types. J Cell Physiol. 2009 Jul; 220(1):129-35. PMID: 19277982.
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    163. Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009 Jun 15; 89(4):1098-107. PMID: 18546185.
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    164. Ward DK, Farkas D, Lian J, Curtin WA, Wang J, Kim KS, Qi Y. Engineering size-scaling of plastic deformation in nanoscale asperities. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9580-5. PMID: 19497857.
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    165. Teplyuk NM, Haupt LM, Ling L, Dombrowski C, Mun FK, Nathan SS, Lian JB, Stein JL, Stein GS, Cool SM, van Wijnen AJ. The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts. J Cell Biochem. 2009 May 1; 107(1):144-54. PMID: 19259985.
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    166. Lian J, Liu JX, Wei YS. Fate of nonylphenol polyethoxylates and their metabolites in four Beijing wastewater treatment plants. Sci Total Environ. 2009 Jul 1; 407(14):4261-8. PMID: 19395065.
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    167. Teplyuk NM, Zhang Y, Lou Y, Hawse JR, Hassan MQ, Teplyuk VI, Pratap J, Galindo M, Stein JL, Stein GS, Lian JB, van Wijnen AJ. The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts. Mol Endocrinol. 2009 Jun; 23(6):849-61. PMID: 19342447.
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    168. Li Z, Hassan MQ, Jafferji M, Aqeilan RI, Garzon R, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation. J Biol Chem. 2009 Jun 5; 284(23):15676-84. PMID: 19342382.
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    169. Pande S, Ali SA, Dowdy C, Zaidi SK, Ito K, Ito Y, Montecino MA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes. J Cell Physiol. 2009 Mar; 218(3):473-9. PMID: 19006109.
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    170. Stuardo M, Martinez M, Hidalgo K, Montecino M, Javed A, Lian JB, Stein GS, Stein JL, Gutiérrez SE. Altered chromatin modifications in AML1/RUNX1 breakpoint regions involved in (8;21) translocation. J Cell Physiol. 2009 Feb; 218(2):343-9. PMID: 18853425.
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    171. Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer. Ann N Y Acad Sci. 2009 Feb; 1155:4-14. PMID: 19250187.
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    172. Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. Transcription-factor-mediated epigenetic control of cell fate and lineage commitment. Biochem Cell Biol. 2009 Feb; 87(1):1-6. PMID: 19234518.
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    173. Lou Y, Javed A, Hussain S, Colby J, Frederick D, Pratap J, Xie R, Gaur T, van Wijnen AJ, Jones SN, Stein GS, Lian JB, Stein JL. A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet. 2009 Feb 1; 18(3):556-68. PMID: 19028669.
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    174. Zhang Y, Hassan MQ, Xie RL, Hawse JR, Spelsberg TC, Montecino M, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats). J Biol Chem. 2009 Jan 30; 284(5):3125-35. PMID: 19017640.
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    175. Bakshi R, Zaidi SK, Pande S, Hassan MQ, Young DW, Montecino M, Lian JB, van Wijnen AJ, Stein JL, Stein GS. The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes. J Cell Sci. 2008 Dec 1; 121(Pt 23):3981-90. PMID: 19001502.
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    176. Jeong JH, Jin JS, Kim HN, Kang SM, Liu JC, Lengner CJ, Otto F, Mundlos S, Stein JL, van Wijnen AJ, Lian JB, Stein GS, Choi JY. Expression of Runx2 transcription factor in non-skeletal tissues, sperm and brain. J Cell Physiol. 2008 Nov; 217(2):511-7. PMID: 18636555.
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    177. Aqeilan RI, Hagan JP, de Bruin A, Rawahneh M, Salah Z, Gaudio E, Siddiqui H, Volinia S, Alder H, Lian JB, Stein GS, Croce CM. Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis. Endocrinology. 2009 Mar; 150(3):1530-5. PMID: 18974271.
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    178. Ghule PN, Dominski Z, Yang XC, Marzluff WF, Becker KA, Harper JW, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells. Proc Natl Acad Sci U S A. 2008 Nov 4; 105(44):16964-9. PMID: 18957539.
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    179. Medina R, Buck T, Zaidi SK, Miele-Chamberland A, Lian JB, Stein JL, van Wijnen AJ, Stein GS. The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif. Biochemistry. 2008 Nov 4; 47(44):11415-23. PMID: 18850719.
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    180. Pratap J, Wixted JJ, Gaur T, Zaidi SK, Dobson J, Gokul KD, Hussain S, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells. Cancer Res. 2008 Oct 1; 68(19):7795-802. PMID: 18829534.
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    181. Trevant B, Gaur T, Hussain S, Symons J, Komm BS, Bodine PV, Stein GS, Lian JB. Expression of secreted frizzled related protein 1, a Wnt antagonist, in brain, kidney, and skeleton is dispensable for normal embryonic development. J Cell Physiol. 2008 Oct; 217(1):113-26. PMID: 18498122.
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    182. Zhang Y, Hassan MQ, Li ZY, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Intricate gene regulatory networks of helix-loop-helix (HLH) proteins support regulation of bone-tissue related genes during osteoblast differentiation. J Cell Biochem. 2008 Oct 1; 105(2):487-96. PMID: 18655182.
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    183. Li Z, Hassan MQ, Volinia S, van Wijnen AJ, Stein JL, Croce CM, Lian JB, Stein GS. A microRNA signature for a BMP2-induced osteoblast lineage commitment program. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13906-11. PMID: 18784367.
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    184. Brown EM, Lian JB. New insights in bone biology: unmasking skeletal effects of the extracellular calcium-sensing receptor. Sci Signal. 2008; 1(35):pe40. PMID: 18765829.
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    185. Javed A, Afzal F, Bae JS, Gutierrez S, Zaidi K, Pratap J, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation. Cells Tissues Organs. 2009; 189(1-4):133-7. PMID: 18728344.
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    186. Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer. J Cell Biochem. 2008 Aug 15; 104(6):2016-26. PMID: 18615590.
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    187. Hassan MQ, Saini S, Gordon JA, van Wijnen AJ, Montecino M, Stein JL, Stein GS, Lian JB. Molecular switches involving homeodomain proteins, HOXA10 and RUNX2 regulate osteoblastogenesis. Cells Tissues Organs. 2009; 189(1-4):122-5. PMID: 18701816.
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    188. Teplyuk NM, Galindo M, Teplyuk VI, Pratap J, Young DW, Lapointe D, Javed A, Stein JL, Lian JB, Stein GS, van Wijnen AJ. Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem. 2008 Oct 10; 283(41):27585-97. PMID: 18625716.
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    189. Fitzgerald TJ, Wang T, Goel HL, Huang J, Stein G, Lian J, Davis RJ, Doxsey S, Balaji KC, Aronowitz J, Languino LR. Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention. Expert Rev Anticancer Ther. 2008 Jun; 8(6):967-74. PMID: 18533806.
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    190. Duverger O, Lee D, Hassan MQ, Chen SX, Jaisser F, Lian JB, Morasso MI. Molecular consequences of a frameshifted DLX3 mutant leading to Tricho-Dento-Osseous syndrome. J Biol Chem. 2008 Jul 18; 283(29):20198-208. PMID: 18492670.
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    191. Aqeilan RI, Hassan MQ, de Bruin A, Hagan JP, Volinia S, Palumbo T, Hussain S, Lee SH, Gaur T, Stein GS, Lian JB, Croce CM. The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem. 2008 Aug 1; 283(31):21629-39. PMID: 18487609.
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    192. Ali SA, Zaidi SK, Dacwag CS, Salma N, Young DW, Shakoori AR, Montecino MA, Lian JB, van Wijnen AJ, Imbalzano AN, Stein GS, Stein JL. Phenotypic transcription factors epigenetically mediate cell growth control. Proc Natl Acad Sci U S A. 2008 May 6; 105(18):6632-7. PMID: 18445650.
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    193. Li S, Tu Q, Zhang J, Stein G, Lian J, Yang PS, Chen J. Systemically transplanted bone marrow stromal cells contributing to bone tissue regeneration. J Cell Physiol. 2008 Apr; 215(1):204-9. PMID: 17960569.
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    194. George KL, Saltman LH, Stein GS, Lian JB, Zurier RB. Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells. J Cell Physiol. 2008 Mar; 214(3):714-20. PMID: 17786950.
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    195. Carvallo L, Henríquez B, Paredes R, Olate J, Onate S, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M. 1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex. J Cell Physiol. 2008 Mar; 214(3):740-9. PMID: 17786964.
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    196. Mukherjee S, Raje N, Schoonmaker JA, Liu JC, Hideshima T, Wein MN, Jones DC, Vallet S, Bouxsein ML, Pozzi S, Chhetri S, Seo YD, Aronson JP, Patel C, Fulciniti M, Purton LE, Glimcher LH, Lian JB, Stein G, Anderson KC, Scadden DT. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest. 2008 Feb; 118(2):491-504. PMID: 18219387.
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    197. Javed A, Bae JS, Afzal F, Gutierrez S, Pratap J, Zaidi SK, Lou Y, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal. J Biol Chem. 2008 Mar 28; 283(13):8412-22. PMID: 18204048.
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    198. Pockwinse SM, Zaidi SK, Medina RF, Bakshi R, Kota KP, Ali SA, Young DW, Nickerson JA, Javed A, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. In situ nuclear organization of regulatory machinery. Methods Mol Biol. 2008; 455:239-59. PMID: 18463823.
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    199. van der Deen M, Hassan MQ, Pratap J, Teplyuk NM, Young DW, Javed A, Zaidi SK, Lian JB, Montecino M, Stein JL, Stein GS, van Wijnen AJ. Chromatin immunoprecipitation assays: application of ChIP-on-chip for defining dynamic transcriptional mechanisms in bone cells. Methods Mol Biol. 2008; 455:165-76. PMID: 18463819.
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    200. Montecino M, Stein GS, Stein JL, Lian JB, van Wijnen AJ, Carvallo L, Marcellini S, Cruzat F, Arriagada G. Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery. Crit Rev Eukaryot Gene Expr. 2008; 18(2):163-72. PMID: 18304030.
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    201. Zaidi SK, Pande S, Pratap J, Gaur T, Grigoriu S, Ali SA, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19861-6. PMID: 18077419.
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    202. Ghule PN, Becker KA, Harper JW, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Cell cycle dependent phosphorylation and subnuclear organization of the histone gene regulator p220(NPAT) in human embryonic stem cells. J Cell Physiol. 2007 Oct; 213(1):9-17. PMID: 17520687.
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    203. Galindo M, Kahler RA, Teplyuk NM, Stein JL, Lian JB, Stein GS, Westendorf JJ, van Wijnen AJ. Cell cycle related modulations in Runx2 protein levels are independent of lymphocyte enhancer-binding factor 1 (Lef1) in proliferating osteoblasts. J Mol Histol. 2007 Oct; 38(5):501-6. PMID: 17885813.
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    204. Montecino M, Stein JL, Stein GS, Lian JB, van Wijnen AJ, Cruzat F, Gutiérrez S, Olate J, Marcellini S, Gutiérrez JL. Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequence. Biochem Cell Biol. 2007 Aug; 85(4):419-25. PMID: 17713577.
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    205. Bruna C, Arriagada G, Lian JB, Stein GS, Bunster M, Martinez-Oyanedel J, Montecino M. Crystallization and preliminary X-ray analysis of a domain in the Runx2 transcription factor that interacts with the 1alpha,25 dihydroxy vitamin D3 receptor. J Cell Biochem. 2007 Jun 1; 101(3):785-9. PMID: 17226779.
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    206. Zaidi SK, Young DW, Javed A, Pratap J, Montecino M, van Wijnen A, Lian JB, Stein JL, Stein GS. Nuclear microenvironments in biological control and cancer. Nat Rev Cancer. 2007 Jun; 7(6):454-63. PMID: 17522714.
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    207. Li JM, Zhang X, Nelson PR, Odgren PR, Nelson JD, Vasiliu C, Park J, Morris M, Lian J, Cutler BS, Newburger PE. Temporal evolution of gene expression in rat carotid artery following balloon angioplasty. J Cell Biochem. 2007 May 15; 101(2):399-410. PMID: 17171642.
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    208. Yeh N, Miller JP, Gaur T, Capellini TD, Nikolich-Zugich J, de la Hoz C, Selleri L, Bromage TG, van Wijnen AJ, Stein GS, Lian JB, Vidal A, Koff A. Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130. Mol Cell Biol. 2007 Jul; 27(14):5161-71. PMID: 17502351.
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    209. Rajgopal A, Young DW, Mujeeb KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells. J Cell Biochem. 2007 Apr 15; 100(6):1509-17. PMID: 17171635.
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    210. Stein GS, Lian JB, van Wijnen AJ, Stein JL, Javed A, Montecino M, Choi JY, Vradii D, Zaidi SK, Pratap J, Young D. Organization of transcriptional regulatory machinery in nuclear microenvironments: implications for biological control and cancer. Adv Enzyme Regul. 2007; 47:242-50. PMID: 17363043.
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    211. Arriagada G, Paredes R, Olate J, van Wijnen A, Lian JB, Stein GS, Stein JL, Onate S, Montecino M. Phosphorylation at serine 208 of the 1alpha,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):425-9. PMID: 17368182.
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    212. Aqeilan RI, Trapasso F, Hussain S, Costinean S, Marshall D, Pekarsky Y, Hagan JP, Zanesi N, Kaou M, Stein GS, Lian JB, Croce CM. Targeted deletion of Wwox reveals a tumor suppressor function. Proc Natl Acad Sci U S A. 2007 Mar 6; 104(10):3949-54. PMID: 17360458.
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    213. Hassan MQ, Tare R, Lee SH, Mandeville M, Weiner B, Montecino M, van Wijnen AJ, Stein JL, Stein GS, Lian JB. HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes. Mol Cell Biol. 2007 May; 27(9):3337-52. PMID: 17325044.
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    214. Young DW, Hassan MQ, Yang XQ, Galindo M, Javed A, Zaidi SK, Furcinitti P, Lapointe D, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3189-94. PMID: 17360627.
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    215. Gutiérrez J, Paredes R, Cruzat F, Hill DA, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Imbalzano AN, Montecino M. Chromatin remodeling by SWI/SNF results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter. J Biol Chem. 2007 Mar 30; 282(13):9445-57. PMID: 17272279.
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    216. Bae JS, Gutierrez S, Narla R, Pratap J, Devados R, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Javed A. Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation. J Cell Biochem. 2007 Feb 1; 100(2):434-49. PMID: 16927309.
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    217. Becker KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells. J Cell Physiol. 2007 Feb; 210(2):517-26. PMID: 17096384.
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    218. Young DW, Hassan MQ, Pratap J, Galindo M, Zaidi SK, Lee SH, Yang X, Xie R, Javed A, Underwood JM, Furcinitti P, Imbalzano AN, Penman S, Nickerson JA, Montecino MA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature. 2007 Jan 25; 445(7126):442-6. PMID: 17251981.
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    219. Carvallo L, Henriquez B, Olate J, van Wijnen AJ, Lian JB, Stein GS, Onate S, Stein JL, Montecino M. The 1alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):420-4. PMID: 17218095.
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    220. Montecino M, Stein GS, Cruzat F, Marcellini S, Stein JL, Lian JB, van Wijnen AJ, Arriagada G. An architectural perspective of vitamin D responsiveness. Arch Biochem Biophys. 2007 Apr 15; 460(2):293-9. PMID: 17288986.
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    221. Stein GS, van Wijnen AJ, Stein JL, Lian JB, Montecino M, Zaidi SK, Braastad C. An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition. J Cell Physiol. 2006 Dec; 209(3):706-10. PMID: 17001681.
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    222. Becker KA, Ghule PN, Therrien JA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase. J Cell Physiol. 2006 Dec; 209(3):883-93. PMID: 16972248.
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    223. Zaidi SK, Javed A, Pratap J, Schroeder TM, J Westendorf J, Lian JB, van Wijnen AJ, Stein GS, Stein JL. Alterations in intranuclear localization of Runx2 affect biological activity. J Cell Physiol. 2006 Dec; 209(3):935-42. PMID: 16972259.
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    224. Pratap J, Lian JB, Javed A, Barnes GL, van Wijnen AJ, Stein JL, Stein GS. Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone. Cancer Metastasis Rev. 2006 Dec; 25(4):589-600. PMID: 17165130.
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    225. Bravo S, Paredes R, Izaurieta P, Lian JB, Stein JL, Stein GS, Hinrichs MV, Olate J, Aguayo LG, Montecino M. The classic receptor for 1alpha,25-dihydroxy vitamin D3 is required for non-genomic actions of 1alpha,25-dihydroxy vitamin D3 in osteosarcoma cells. J Cell Biochem. 2006 Nov 1; 99(4):995-1000. PMID: 16927375.
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    226. Hassan MQ, Tare RS, Lee SH, Mandeville M, Morasso MI, Javed A, van Wijnen AJ, Stein JL, Stein GS, Lian JB. BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network. J Biol Chem. 2006 Dec 29; 281(52):40515-26. PMID: 17060321.
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    227. Gaur T, Rich L, Lengner CJ, Hussain S, Trevant B, Ayers D, Stein JL, Bodine PV, Komm BS, Stein GS, Lian JB. Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation. J Cell Physiol. 2006 Jul; 208(1):87-96. PMID: 16575902.
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    228. Villagra A, Cruzat F, Carvallo L, Paredes R, Olate J, van Wijnen AJ, Stein GS, Lian JB, Stein JL, Imbalzano AN, Montecino M. Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity. J Biol Chem. 2006 Aug 11; 281(32):22695-706. PMID: 16772287.
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    229. Lian JB, Stein GS, Javed A, van Wijnen AJ, Stein JL, Montecino M, Hassan MQ, Gaur T, Lengner CJ, Young DW. Networks and hubs for the transcriptional control of osteoblastogenesis. Rev Endocr Metab Disord. 2006 Jun; 7(1-2):1-16. PMID: 17051438.
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    230. Kim HJ, Nam SH, Kim HJ, Park HS, Ryoo HM, Kim SY, Cho TJ, Kim SG, Bae SC, Kim IS, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Choi JY. Four novel RUNX2 mutations including a splice donor site result in the cleidocranial dysplasia phenotype. J Cell Physiol. 2006 Apr; 207(1):114-22. PMID: 16270353.
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    231. Kahler RA, Galindo M, Lian J, Stein GS, van Wijnen AJ, Westendorf JJ. Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts. J Cell Biochem. 2006 Apr 1; 97(5):969-83. PMID: 16267835.
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    232. Lengner CJ, Steinman HA, Gagnon J, Smith TW, Henderson JE, Kream BE, Stein GS, Lian JB, Jones SN. Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol. 2006 Mar 13; 172(6):909-21. PMID: 16533949.
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    233. Pockwinse SM, Rajgopal A, Young DW, Mujeeb KA, Nickerson J, Javed A, Redick S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Doxsey SJ. Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2. J Cell Physiol. 2006 Feb; 206(2):354-62. PMID: 16110492.
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    234. Vradii D, Wagner S, Doan DN, Nickerson JA, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Imbalzano AN, Stein GS. Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes. J Cell Physiol. 2006 Jan; 206(1):112-8. PMID: 15965950.
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    235. Bodine PV, Billiard J, Moran RA, Ponce-de-Leon H, McLarney S, Mangine A, Scrimo MJ, Bhat RA, Stauffer B, Green J, Stein GS, Lian JB, Komm BS. The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis. J Cell Biochem. 2005 Dec 15; 96(6):1212-30. PMID: 16149051.
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    236. Kim YJ, Kim HN, Park EK, Lee BH, Ryoo HM, Kim SY, Kim IS, Stein JL, Lian JB, Stein GS, van Wijnen AJ, Choi JY. The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cells. Gene. 2006 Jan 17; 366(1):145-51. PMID: 16314050.
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    237. Li X, Vradii D, Gutierrez S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Javed A. Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1. J Cell Biochem. 2005 Nov 1; 96(4):795-809. PMID: 16149049.
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    238. Pratap J, Javed A, Languino LR, van Wijnen AJ, Stein JL, Stein GS, Lian JB. The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol. 2005 Oct; 25(19):8581-91. PMID: 16166639.
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    239. Saltman LH, Javed A, Ribadeneyra J, Hussain S, Young DW, Osdoby P, Amcheslavsky A, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Bar-Shavit Z. Organization of transcriptional regulatory machinery in osteoclast nuclei: compartmentalization of Runx1. J Cell Physiol. 2005 Sep; 204(3):871-80. PMID: 15828028.
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    240. Stein GS, Lian JB, Stein JL, van Wijnen AJ, Javed A, Montecino M, Zaidi SK, Young DW, Choi JY, Pratap J. Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer. Adv Enzyme Regul. 2005; 45:136-54. PMID: 16135382.
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    241. Gaur T, Lengner CJ, Hovhannisyan H, Bhat RA, Bodine PV, Komm BS, Javed A, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J Biol Chem. 2005 Sep 30; 280(39):33132-40. PMID: 16043491.
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    242. Afzal F, Pratap J, Ito K, Ito Y, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Javed A. Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol. 2005 Jul; 204(1):63-72. PMID: 15573378.
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    243. Vradii D, Zaidi SK, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7174-9. PMID: 15870195.
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    244. Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, Drissi MH. Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J Cell Physiol. 2005 Apr; 203(1):133-43. PMID: 15389629.
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    245. Galindo M, Pratap J, Young DW, Hovhannisyan H, Im HJ, Choi JY, Lian JB, Stein JL, Stein GS, van Wijnen AJ. The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts. J Biol Chem. 2005 May 27; 280(21):20274-85. PMID: 15781466.
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    246. Young DW, Pratap J, Javed A, Weiner B, Ohkawa Y, van Wijnen A, Montecino M, Stein GS, Stein JL, Imbalzano AN, Lian JB. SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J Cell Biochem. 2005 Mar 1; 94(4):720-30. PMID: 15565649.
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    247. Lengner CJ, Hassan MQ, Serra RW, Lepper C, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation. J Biol Chem. 2005 Apr 22; 280(16):15872-9. PMID: 15703179.
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    248. Zaidi SK, Young DW, Choi JY, Pratap J, Javed A, Montecino M, Stein JL, van Wijnen AJ, Lian JB, Stein GS. The dynamic organization of gene-regulatory machinery in nuclear microenvironments. EMBO Rep. 2005 Feb; 6(2):128-33. PMID: 15689940.
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    249. Javed A, Barnes GL, Pratap J, Antkowiak T, Gerstenfeld LC, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5):1454-9. PMID: 15665096.
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    250. Yunker LA, Undersander A, Lian JB, Stein GS, Carlson CS, Mauro LJ. The tyrosine phosphatase, OST-PTP, is expressed in mesenchymal progenitor cells early during skeletogenesis in the mouse. J Cell Biochem. 2004 Nov 1; 93(4):761-73. PMID: 15660420.
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    251. Lian J, Xing L, Hunjan S, Dumoulin C, Levin J, Lo A, Watkins R, Rohling K, Giaquinto R, Kim D, Spielman D, Daniel B. Mapping of the prostate in endorectal coil-based MRI/MRSI and CT: a deformable registration and validation study. Med Phys. 2004 Nov; 31(11):3087-94. PMID: 15587662.
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    252. Paredes R, Arriagada G, Cruzat F, Villagra A, Olate J, Zaidi K, van Wijnen A, Lian JB, Stein GS, Stein JL, Montecino M. Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. Mol Cell Biol. 2004 Oct; 24(20):8847-61. PMID: 15456860.
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    253. Hassan MQ, Javed A, Morasso MI, Karlin J, Montecino M, van Wijnen AJ, Stein GS, Stein JL, Lian JB. Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene. Mol Cell Biol. 2004 Oct; 24(20):9248-61. PMID: 15456894.
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    254. Young DW, Zaidi SK, Furcinitti PS, Javed A, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Quantitative signature for architectural organization of regulatory factors using intranuclear informatics. J Cell Sci. 2004 Oct 1; 117(Pt 21):4889-96. PMID: 15367579.
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    255. Lengner CJ, Lepper C, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Primary mouse embryonic fibroblasts: a model of mesenchymal cartilage formation. J Cell Physiol. 2004 Sep; 200(3):327-33. PMID: 15254959.
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    256. Gutierrez S, Liu J, Javed A, Montecino M, Stein GS, Lian JB, Stein JL. The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain. J Biol Chem. 2004 Oct 15; 279(42):43581-8. PMID: 15299011.
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    257. Zaidi SK, Young DW, Choi JY, Pratap J, Javed A, Montecino M, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Intranuclear trafficking: organization and assembly of regulatory machinery for combinatorial biological control. J Biol Chem. 2004 Oct 15; 279(42):43363-6. PMID: 15277516.
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    258. Barnes GL, Hebert KE, Kamal M, Javed A, Einhorn TA, Lian JB, Stein GS, Gerstenfeld LC. Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease. Cancer Res. 2004 Jul 1; 64(13):4506-13. PMID: 15231660.
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    259. Stein GS, Lian JB, van Wijnen AJ, Stein JL, Montecino M, Javed A, Zaidi SK, Young DW, Choi JY, Pockwinse SM. Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene. 2004 May 24; 23(24):4315-29. PMID: 15156188.
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    260. Paredes R, Arriagada G, Cruzat F, Olate J, Van Wijnen A, Lian J, Stein G, Stein J, Montecino M. The Runx2 transcription factor plays a key role in the 1alpha,25-dihydroxy Vitamin D3-dependent upregulation of the rat osteocalcin (OC) gene expression in osteoblastic cells. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):269-71. PMID: 15225783.
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    261. Bodine PV, Zhao W, Kharode YP, Bex FJ, Lambert AJ, Goad MB, Gaur T, Stein GS, Lian JB, Komm BS. The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol. 2004 May; 18(5):1222-37. PMID: 14976225.
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    262. Zaidi SK, Sullivan AJ, Medina R, Ito Y, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. EMBO J. 2004 Feb 25; 23(4):790-9. PMID: 14765127.
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    263. Stein GS, Lian JB, van Wijnen AJ, Stein JL, Javed A, Montecino M, Zaidi SK, Young D, Choi JY, Gutierrez S, Pockwinse S. Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation. J Cell Biochem. 2004 Feb 1; 91(2):287-302. PMID: 14743389.
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    264. Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. In situ immunofluorescence analysis: immunofluorescence microscopy. Methods Mol Biol. 2004; 285:23-8. PMID: 15269392.
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    265. Lian JB, Javed A, Zaidi SK, Lengner C, Montecino M, van Wijnen AJ, Stein JL, Stein GS. Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors. Crit Rev Eukaryot Gene Expr. 2004; 14(1-2):1-41. PMID: 15104525.
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    266. Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Protein-deoxyribonucleic acid interactions linked to gene expression: ligation-mediated polymerase chain reaction. Methods Mol Biol. 2004; 285:63-7. PMID: 15269399.
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    267. Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Protein-deoxyribonucleic acid interactions linked to gene expression: DNase I digestion. Methods Mol Biol. 2004; 285:57-62. PMID: 15269398.
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    268. Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Protein-deoxyribonucleic acid interactions linked to gene expression: electrophoretic mobility shift assay. Methods Mol Biol. 2004; 285:45-55. PMID: 15269397.
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    269. Stein GS, Stein JL, Lian JB, Van Wijnen AJ, Montecino M, Javed A, Zaidi SK, Young D, Choi JY, Pockwinse S. Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals. Eur J Histochem. 2004; 48(1):65-76. PMID: 15145777.
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    270. Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Analysis of in vivo gene expression using epitope-tagged proteins. Methods Mol Biol. 2004; 285:37-40. PMID: 15269395.
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    271. Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Chromatin immunoprecipitation. Methods Mol Biol. 2004; 285:41-4. PMID: 15269396.
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    272. Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. In situ immunofluorescence analysis: analyzing RNA synthesis by 5-bromouridine-5'-triphosphate labeling. Methods Mol Biol. 2004; 285:29-31. PMID: 15269393.
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    273. Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Immunofluorescence analysis using epitope-tagged proteins: in vitro system. Methods Mol Biol. 2004; 285:33-6. PMID: 15269394.
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    274. Kim JO, Kim HN, Hwang MH, Shin HI, Kim SY, Park RW, Park EY, Kim IS, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Choi JY. Differential gene expression analysis using paraffin-embedded tissues after laser microdissection. J Cell Biochem. 2003 Dec 1; 90(5):998-1006. PMID: 14624459.
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    275. Zaidi SK, Young DW, Pockwinse SM, Javed A, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells. Proc Natl Acad Sci U S A. 2003 Dec 9; 100(25):14852-7. PMID: 14657346.
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    276. Stein GS, Zaidi SK, Braastad CD, Montecino M, van Wijnen AJ, Choi JY, Stein JL, Lian JB, Javed A. Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair. Trends Cell Biol. 2003 Nov; 13(11):584-92. PMID: 14573352.
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    277. Pratap J, Galindo M, Zaidi SK, Vradii D, Bhat BM, Robinson JA, Choi JY, Komori T, Stein JL, Lian JB, Stein GS, van Wijnen AJ. Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts. Cancer Res. 2003 Sep 1; 63(17):5357-62. PMID: 14500368.
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    278. Lian JB, Balint E, Javed A, Drissi H, Vitti R, Quinlan EJ, Zhang L, Van Wijnen AJ, Stein JL, Speck N, Stein GS. Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo. J Cell Physiol. 2003 Aug; 196(2):301-11. PMID: 12811823.
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    279. Bidinger B, Torres R, Rossetti RG, Brown L, Beltre R, Burstein S, Lian JB, Stein GS, Zurier RB. Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes. Clin Immunol. 2003 Aug; 108(2):95-102. PMID: 12921755.
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    280. Zhang C, Dowd DR, Staal A, Gu C, Lian JB, van Wijnen AJ, Stein GS, MacDonald PN. Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. J Biol Chem. 2003 Sep 12; 278(37):35325-36. PMID: 12840015.
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    281. Lian JB, Stein GS. The temporal and spatial subnuclear organization of skeletal gene regulatory machinery: integrating multiple levels of transcriptional control. Calcif Tissue Int. 2003 Jun; 72(6):631-7. PMID: 14562989.
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    282. Balint E, Lapointe D, Drissi H, van der Meijden C, Young DW, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation. J Cell Biochem. 2003 May 15; 89(2):401-26. PMID: 12704803.
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    283. Barnes GL, Javed A, Waller SM, Kamal MH, Hebert KE, Hassan MQ, Bellahcene A, Van Wijnen AJ, Young MF, Lian JB, Stein GS, Gerstenfeld LC. Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. Cancer Res. 2003 May 15; 63(10):2631-7. PMID: 12750290.
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    284. Sierra J, Villagra A, Paredes R, Cruzat F, Gutierrez S, Javed A, Arriagada G, Olate J, Imschenetzky M, Van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M. Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Mol Cell Biol. 2003 May; 23(9):3339-51. PMID: 12697832.
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    285. Stein GS, Lian JB, Stein JL, van Wijnen AJ, Montecino M, Pratap J, Choi J, Zaidi SK, Javed A, Gutierrez S, Harrington K, Shen J, Young D. Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer. Blood Cells Mol Dis. 2003 Mar-Apr; 30(2):170-6. PMID: 12732180.
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    286. Stein GS, Lian JB, Stein JL, Wijnen AJ, Montecino M, Javed A, Pratap J, Choi J, Zaidi SK, Gutierrez S, Harrington K, Shen J, Young D. Intranuclear trafficking of transcription factors: Requirements for vitamin D-mediated biological control of gene expression. J Cell Biochem. 2003 Feb 1; 88(2):340-55. PMID: 12520536.
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    287. Shen J, Hovhannisyan H, Lian JB, Montecino MA, Stein GS, Stein JL, Van Wijnen AJ. Transcriptional induction of the osteocalcin gene during osteoblast differentiation involves acetylation of histones h3 and h4. Mol Endocrinol. 2003 Apr; 17(4):743-56. PMID: 12554783.
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    288. Lian JB, Stein GS. Runx2/Cbfa1: a multifunctional regulator of bone formation. Curr Pharm Des. 2003; 9(32):2677-85. PMID: 14529540.
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    289. Stein GS, Lian JB, Stein JL, van Wijnen AJ, Choi JY, Pratap J, Zaidi SK. Temporal and spatial parameters of skeletal gene expression: targeting RUNX factors and their coregulatory proteins to subnuclear domains. Connect Tissue Res. 2003; 44 Suppl 1:149-53. PMID: 12952189.
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    290. Stein GS, Lian JB, Montecino M, Stein JL, van Wijnen AJ, Javed A, Pratap J, Choi J, Zaidi SK, Gutierrez S, Harrington K, Shen J, Young D, Pockwinse S. Nuclear microenvironments support physiological control of gene expression. Chromosome Res. 2003; 11(5):527-36. PMID: 12971727.
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    291. Lian JB, Stein JL, Stein GS, van Wijnen AJ, Montecino M, Javed A, Gutierrez S, Shen J, Zaidi SK, Drissi H. Runx2/Cbfa1 functions: diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions. Connect Tissue Res. 2003; 44 Suppl 1:141-8. PMID: 12952188.
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    292. Miller J, Horner A, Stacy T, Lowrey C, Lian JB, Stein G, Nuckolls GH, Speck NA. The core-binding factor beta subunit is required for bone formation and hematopoietic maturation. Nat Genet. 2002 Dec; 32(4):645-9. PMID: 12434155.
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    293. Kundu M, Javed A, Jeon JP, Horner A, Shum L, Eckhaus M, Muenke M, Lian JB, Yang Y, Nuckolls GH, Stein GS, Liu PP. Cbfbeta interacts with Runx2 and has a critical role in bone development. Nat Genet. 2002 Dec; 32(4):639-44. PMID: 12434156.
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    294. Barseguian K, Lutterbach B, Hiebert SW, Nickerson J, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15434-9. PMID: 12427969.
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    295. Harrington KS, Javed A, Drissi H, McNeil S, Lian JB, Stein JL, Van Wijnen AJ, Wang YL, Stein GS. Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains. J Cell Sci. 2002 Nov 1; 115(Pt 21):4167-76. PMID: 12356919.
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    296. Lian J, Li G, Cheng J, Avitall B, He B. Body surface Laplacian mapping of atrial depolarization in healthy human subjects. Med Biol Eng Comput. 2002 Nov; 40(6):650-9. PMID: 12507316.
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    297. Westendorf JJ, Zaidi SK, Cascino JE, Kahler R, van Wijnen AJ, Lian JB, Yoshida M, Stein GS, Li X. Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol Cell Biol. 2002 Nov; 22(22):7982-92. PMID: 12391164.
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    298. He B, Zhang X, Lian J, Sasaki H, Wu D, Towle VL. Boundary element method-based cortical potential imaging of somatosensory evoked potentials using subjects' magnetic resonance images. Neuroimage. 2002 Jul; 16(3 Pt 1):564-76. PMID: 12169243.
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    299. Zaidi SK, Sullivan AJ, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8048-53. PMID: 12060751.
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    300. Lengner CJ, Drissi H, Choi JY, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Activation of the bone-related Runx2/Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton. Mech Dev. 2002 Jun; 114(1-2):167-70. PMID: 12175505.
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    301. Paredes R, Gutiérrez J, Gutierrez S, Allison L, Puchi M, Imschenetzky M, van Wijnen A, Lian J, Stein G, Stein J, Montecino M. Interaction of the 1alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling. Biochem J. 2002 May 1; 363(Pt 3):667-76. PMID: 11964167.
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    302. Drissi H, Pouliot A, Koolloos C, Stein JL, Lian JB, Stein GS, van Wijnen AJ. 1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter. Exp Cell Res. 2002 Apr 1; 274(2):323-33. PMID: 11900492.
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    303. Shen J, Montecino M, Lian JB, Stein GS, Van Wijnen AJ, Stein JL. Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription. J Biol Chem. 2002 Jun 7; 277(23):20284-92. PMID: 11893738.
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    304. Luong MX, van der Meijden CM, Xing D, Hesselton R, Monuki ES, Jones SN, Lian JB, Stein JL, Stein GS, Neufeld EJ, van Wijnen AJ. Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility. Mol Cell Biol. 2002 Mar; 22(5):1424-37. PMID: 11839809.
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    305. Chen J, Lian J, Wang LM, Ewing RC, Wang RG, Pan W. X-ray photoelectron spectroscopy study of disordering in Gd2(Ti1-xZrx)2O7 pyrochlores. Phys Rev Lett. 2002 Mar 11; 88(10):105901. PMID: 11909374.
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    306. van den Bemd GJ, Jhamai M, Staal A, van Wijnen AJ, Lian JB, Stein GS, Pols HA, van Leeuwen JP. A central dinucleotide within vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands. J Biol Chem. 2002 Apr 26; 277(17):14539-46. PMID: 11834737.
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    307. Drissi H, Pouliot A, Stein JL, van Wijnen AJ, Stein GS, Lian JB. Identification of novel protein/DNA interactions within the promoter of the bone-related transcription factor Runx2/Cbfa1. J Cell Biochem. 2002; 86(2):403-12. PMID: 12112009.
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    308. Villagra A, Gutiérrez J, Paredes R, Sierra J, Puchi M, Imschenetzky M, Wijnen Av Av, Lian J, Stein G, Stein J, Montecino M. Reduced CpG methylation is associated with transcriptional activation of the bone-specific rat osteocalcin gene in osteoblasts. J Cell Biochem. 2002; 85(1):112-22. PMID: 11891855.
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    309. Lian J, Marcinkiewicz C, Niewiarowski S, Beacham DA. Extracellular signal-regulated kinase (ERK) activation is required for GP Ibalpha-dependent endothelial cell migration. Thromb Haemost. 2001 Dec; 86(6):1555-62. PMID: 11776327.
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    310. Gilbert L, He X, Farmer P, Rubin J, Drissi H, van Wijnen AJ, Lian JB, Stein GS, Nanes MS. Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. J Biol Chem. 2002 Jan 25; 277(4):2695-701. PMID: 11723115.
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    311. Lian J, Bikson M, Shuai J, Durand DM. Propagation of non-synaptic epileptiform activity across a lesion in rat hippocampal slices. J Physiol. 2001 Nov 15; 537(Pt 1):191-9. PMID: 11711572.
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    312. Gutierrez S, Javed A, Tennant DK, van Rees M, Montecino M, Stein GS, Stein JL, Lian JB. CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression. J Biol Chem. 2002 Jan 11; 277(2):1316-23. PMID: 11668178.
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    313. Lian J, Wang LM, Wang SX, Chen J, Boatner LA, Ewing RC. Nanoscale manipulation of pyrochlore: new nanocomposite ionic conductors. Phys Rev Lett. 2001 Oct 1; 87(14):145901. PMID: 11580662.
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    314. Zaidi SK, Javed A, Choi JY, van Wijnen AJ, Stein JL, Lian JB, Stein GS. A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene. J Cell Sci. 2001 Sep; 114(Pt 17):3093-102. PMID: 11590236.
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    315. Banerjee C, Javed A, Choi JY, Green J, Rosen V, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Differential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype. Endocrinology. 2001 Sep; 142(9):4026-39. PMID: 11517182.
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    316. Le Page C, Popescu O, Génin P, Lian J, Paquin A, Galipeau J, Hiscott J. Disruption of NF-kappa B signaling and chemokine gene activation by retroviral mediated expression of IKK gamma/NEMO mutants. Virology. 2001 Aug 1; 286(2):422-33. PMID: 11485410.
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    317. Shuai JW, Lian J, Hahn PJ, Durand DM. Positive Lyapunov exponents calculated from time series of strange nonchaotic attractors. Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Aug; 64(2 Pt 2):026220. PMID: 11497690.
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    318. Choi JY, Pratap J, Javed A, Zaidi SK, Xing L, Balint E, Dalamangas S, Boyce B, van Wijnen AJ, Lian JB, Stein JL, Jones SN, Stein GS. Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8650-5. PMID: 11438701.
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    319. He B, Lian J, Li G. High-resolution EEG: a new realistic geometry spline Laplacian estimation technique. Clin Neurophysiol. 2001 May; 112(5):845-52. PMID: 11336900.
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    320. Javed A, Barnes GL, Jasanya BO, Stein JL, Gerstenfeld L, Lian JB, Stein GS. runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteins. Mol Cell Biol. 2001 Apr; 21(8):2891-905. PMID: 11283267.
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    321. Lian JB, Stein JL, Stein GS, Montecino M, van Wijnen AJ, Javed A, Gutierrez S. Contributions of nuclear architecture and chromatin to vitamin D-dependent transcriptional control of the rat osteocalcin gene. Steroids. 2001 Mar-May; 66(3-5):159-70. PMID: 11179723.
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    322. Shopland LS, Byron M, Stein JL, Lian JB, Stein GS, Lawrence JB. Replication-dependent histone gene expression is related to Cajal body (CB) association but does not require sustained CB contact. Mol Biol Cell. 2001 Mar; 12(3):565-76. PMID: 11251071.
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    323. Bikson M, Lian J, Hahn PJ, Stacey WC, Sciortino C, Durand DM. Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices. J Physiol. 2001 Feb 15; 531(Pt 1):181-91. PMID: 11179402.
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    324. Lian J, Shuai J, Hahn P, Durand DM. Nonlinear dynamic properties of low calcium-induced epileptiform activity. Brain Res. 2001 Feb 2; 890(2):246-54. PMID: 11164790.
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    325. Prince M, Banerjee C, Javed A, Green J, Lian JB, Stein GS, Bodine PV, Komm BS. Expression and regulation of Runx2/Cbfa1 and osteoblast phenotypic markers during the growth and differentiation of human osteoblasts. J Cell Biochem. 2001; 80(3):424-40. PMID: 11135373.
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    326. Chenoufi HL, Diamant M, Rieneck K, Lund B, Stein GS, Lian JB. Increased mRNA expression and protein secretion of interleukin-6 in primary human osteoblasts differentiated in vitro from rheumatoid and osteoarthritic bone. J Cell Biochem. 2001; 81(4):666-78. PMID: 11329621.
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    327. Gutiérrez J, Sierra J, Medina R, Puchi M, Imschenetzky M, van Wijnen A, Lian J, Stein G, Stein J, Montecino M. Interaction of CBF alpha/AML/PEBP2 alpha transcription factors with nucleosomes containing promoter sequences requires flexibility in the translational positioning of the histone octamer and exposure of the CBF alpha site. Biochemistry. 2000 Nov 7; 39(44):13565-74. PMID: 11063594.
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    328. Lian JB, Stein GS, Stein JL, van Wijnen AJ. Marrow transplantation and targeted gene therapy to the skeleton. Clin Orthop Relat Res. 2000 Oct; (379 Suppl):S146-55. PMID: 11039763.
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    329. Lian JB, Niyibizi C. Gene therapy for genetic diseases of bone. Clin Orthop Relat Res. 2000 Oct; (379 Suppl):S159-63. PMID: 11039765.
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    330. Hoffmann H, Green J, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Expression screening of factors binding to the osteocalcin bone-specific promoter element OC box I: isolation of a novel osteoblast differentiation-specific factor. J Cell Biochem. 2000 Sep 18; 80(1):156-68. PMID: 11029763.
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    331. Zhong Y, Cheng F, Zhou Y, Lian J, Ye W, Wang K. The changes of TGF-alpha, TGF-beta 1 and basic FGF messenger RNA expression in rabbit cornea after photorefractive keratectomy. Yan Ke Xue Bao. 2000 Sep; 16(3):176-80. PMID: 12579643.
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    332. Drissi H, Luc Q, Shakoori R, Chuva De Sousa Lopes S, Choi JY, Terry A, Hu M, Jones S, Neil JC, Lian JB, Stein JL, Van Wijnen AJ, Stein GS. Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene. J Cell Physiol. 2000 Sep; 184(3):341-50. PMID: 10911365.
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    333. McNeil S, Javed A, Harrington KS, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Leukemia-associated AML1/ETO (8;21) chromosomal translocation protein increases the cellular representation of PML bodies. J Cell Biochem. 2000 Jul 19; 79(1):103-12. PMID: 10906759.
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    334. Stein GS, van Wijnen AJ, Stein JL, Lian JB, Montecino M, Choi J, Zaidi K, Javed A. Intranuclear trafficking of transcription factors: implications for biological control. J Cell Sci. 2000 Jul; 113 ( Pt 14):2527-33. PMID: 10862710.
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    335. Stein GS, Lian JB, Stein JL, van Wijnen AJ. Bone tissue specific transcriptional control: options for targeting gene therapy to the skeleton. Cancer. 2000 Jun 15; 88(12 Suppl):2899-902. PMID: 10898331.
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    336. Javed A, Guo B, Hiebert S, Choi JY, Green J, Zhao SC, Osborne MA, Stifani S, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. J Cell Sci. 2000 Jun; 113 ( Pt 12):2221-31. PMID: 10825294.
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    337. Stein GS, Montecino M, van Wijnen AJ, Stein JL, Lian JB. Nuclear structure-gene expression interrelationships: implications for aberrant gene expression in cancer. Cancer Res. 2000 Apr 15; 60(8):2067-76. PMID: 10786661.
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    338. Gordon JA, Pockwinse SM, Stewart FM, Quesenberry PJ, Nakamura T, Croce CM, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Modified intranuclear organization of regulatory factors in human acute leukemias: reversal after treatment. J Cell Biochem. 2000 Feb; 77(1):30-43. PMID: 10679814.
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    339. Cai G, Lian J, Shapiro SS, Beacham DA. Evaluation of endothelial cell migration with a novel in vitro assay system. Methods Cell Sci. 2000; 22(2-3):107-14. PMID: 11264960.
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    340. Brown RS, Shalhoub V, Coulter S, Alex S, Joris I, De Vito W, Lian J, Stein GS. Developmental regulation of thyrotropin receptor gene expression in the fetal and neonatal rat thyroid: relation to thyroid morphology and to thyroid-specific gene expression. Endocrinology. 2000 Jan; 141(1):340-5. PMID: 10614656.
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    341. Stein GS, van Wijnen AJ, Stein JL, Lian JB, Montecino M, Zaidi K, Javed A. Subnuclear organization and trafficking of regulatory proteins: implications for biological control and cancer. J Cell Biochem Suppl. 2000; Suppl 35:84-92. PMID: 11389536.
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    342. Brown RS, Shalhoub V, Coulter S, Alex S, Joris I, De Vito W, Lian J, Stein GS. Developmental Regulation of Thyrotropin Receptor Gene Expression in the Fetal and Neonatal Rat Thyroid: Relation to Thyroid Morphology and to Thyroid-Specific Gene Expression1. Endocrinology. 2000 Jan 01; 141(1):340-345. PMID: 28200989.
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    343. McNeil S, Zeng C, Harrington KS, Hiebert S, Lian JB, Stein JL, van Wijnen AJ, Stein GS. The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14882-7. PMID: 10611307.
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    344. van Gurp MF, Pratap J, Luong M, Javed A, Hoffmann H, Giordano A, Stein JL, Neufeld EJ, Lian JB, Stein GS, van Wijnen AJ. The CCAAT displacement protein/cut homeodomain protein represses osteocalcin gene transcription and forms complexes with the retinoblastoma protein-related protein p107 and cyclin A. Cancer Res. 1999 Dec 1; 59(23):5980-8. PMID: 10606245.
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    345. Stein GS, van Wijnen AJ, Stein JL, Lian JB, Javed A, McNeil S, Pockwinse SM. Insight into regulatory factor targeting to transcriptionally active subnuclear sites. Exp Cell Res. 1999 Nov 25; 253(1):110-6. PMID: 10579916.
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    346. Tang L, Guo B, Javed A, Choi JY, Hiebert S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Zhou GW. Crystal structure of the nuclear matrix targeting signal of the transcription factor acute myelogenous leukemia-1/polyoma enhancer-binding protein 2alphaB/core binding factor alpha2. J Biol Chem. 1999 Nov 19; 274(47):33580-6. PMID: 10559245.
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    347. Stein GS, Van Wijnen AJ, Montecino M, Stein JL, Lian JB. Nuclear structure/gene expression interrelationships. J Cell Physiol. 1999 Nov; 181(2):240-50. PMID: 10497303.
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    348. Javed A, Gutierrez S, Montecino M, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization. Mol Cell Biol. 1999 Nov; 19(11):7491-500. PMID: 10523637.
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    349. Lian J, Guoping C, Shapiro SS, Tran LP, Beacham DA. Glycoprotein Ibalpha can mediate endothelial cell migration on von Willebrand factor-containing substrata. Exp Cell Res. 1999 Oct 10; 252(1):114-22. PMID: 10502404.
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    350. Drissi H, Hushka D, Aslam F, Nguyen Q, Buffone E, Koff A, van Wijnen A, Lian JB, Stein JL, Stein GS. The cell cycle regulator p27kip1 contributes to growth and differentiation of osteoblasts. Cancer Res. 1999 Aug 1; 59(15):3705-11. PMID: 10446985.
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    351. Feng Z, Zhou Y, Jia Z, Lian J, Li J, Li W. [Immune responses to recombinant expression plasmid encoding hepatitis C virus core antigen]. Zhonghua Nei Ke Za Zhi. 1999 Jul; 38(7):462-5. PMID: 11798682.
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    352. Qi Y, Lian J, Wang K, Wang Y. [The immunohistochemical changes of TGF-beta, type I and III collagen in corneal healing after photorefractive keratectomy]. Zhonghua Yan Ke Za Zhi. 1999 Jul; 35(4):274-6, 15. PMID: 11835821.
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    353. Hou Z, Nguyen Q, Frenkel B, Nilsson SK, Milne M, van Wijnen AJ, Stein JL, Quesenberry P, Lian JB, Stein GS. Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7294-9. PMID: 10377408.
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    354. Beacham DA, Lian J, Wu G, Konkle BA, Ludlow LB, Shapiro SS. Arterial shear stress stimulates surface expression of the endothelial glycoprotein Ib complex. J Cell Biochem. 1999 Jun 15; 73(4):508-21. PMID: 10720423.
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    355. Lee MH, Javed A, Kim HJ, Shin HI, Gutierrez S, Choi JY, Rosen V, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Ryoo HM. Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation. J Cell Biochem. 1999 Apr 1; 73(1):114-25. PMID: 10088730.
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    356. Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Phosphorylation-mediated control of chromatin organization and transcriptional activity of the tissue-specific osteocalcin gene. J Cell Biochem. 1999 Mar 15; 72(4):586-94. PMID: 10022617.
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    357. Nilsson SK, Dooner MS, Weier HU, Frenkel B, Lian JB, Stein GS, Quesenberry PJ. Cells capable of bone production engraft from whole bone marrow transplants in nonablated mice. J Exp Med. 1999 Feb 15; 189(4):729-34. PMID: 9989988.
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    358. Montecino M, Frenkel B, van Wijnen AJ, Lian JB, Stein GS, Stein JL. Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo. Biochemistry. 1999 Jan 26; 38(4):1338-45. PMID: 9930996.
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    359. Stein GS, van Wijnen AJ, Stein JL, Lian JB. Interrelationships of transcriptional machinery with nuclear architecture. Crit Rev Eukaryot Gene Expr. 1999; 9(3-4):183-90. PMID: 10651235.
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    360. Aslam F, McCabe L, Frenkel B, van Wijnen AJ, Stein GS, Lian JB, Stein JL. AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation. Endocrinology. 1999 Jan; 140(1):63-70. PMID: 9886808.
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    361. Stein GS, van Wijnen AJ, Stein JL, Lian JB, McNeil S, Pockwinse SM. Transcriptional control within the three-dimensional context of nuclear architecture: requirements for boundaries and direction. J Cell Biochem. 1999; Suppl 32-33:24-31. PMID: 10629100.
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    362. Stein GS, van Wijnen AJ, Stein JL, Lian JB, Pockwinse SH, McNeil S. Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions. FASEB J. 1999; 13 Suppl:S157-66. PMID: 10352158.
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    363. Lian JB, Stein GS, Stein JL, van Wijnen AJ. Regulated expression of the bone-specific osteocalcin gene by vitamins and hormones. Vitam Horm. 1999; 55:443-509. PMID: 9949687.
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    364. Aslam F, McCabe L, Frenkel B, van Wijnen AJ, Stein GS, Lian JB, Stein JL. AP-1 and Vitamin D Receptor (VDR) Signaling Pathways Converge at the Rat Osteocalcin VDR Element: Requirement for the Internal Activating Protein-1 Site for Vitamin D-Mediated Trans-Activation* *This work was supported by NIH Grants AR-45689, AR-39588, and DE-12528. The contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Endocrinology. 1999 Jan 01; 140(1):63-70. PMID: 28200572.
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    365. Choi JY, van Wijnen AJ, Aslam F, Leszyk JD, Stein JL, Stein GS, Lian JB, Penman S. Developmental association of the beta-galactoside-binding protein galectin-1 with the nuclear matrix of rat calvarial osteoblasts. J Cell Sci. 1998 Oct; 111 ( Pt 20):3035-43. PMID: 9739077.
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    366. Tang L, Guo B, van Wijnen AJ, Lian JB, Stein JL, Stein GS, Zhou GW. Preliminary crystallographic study of glutathione S-transferase fused with the nuclear matrix targeting signal of the transcription factor AML-1/CBF-alpha2. J Struct Biol. 1998 Sep; 123(1):83-5. PMID: 9774548.
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    367. Stein GS, van Wijnen AJ, Stein JL, Lian JB, Pockwinse S, McNeil S. Interrelationships of nuclear structure and transcriptional control: functional consequences of being in the right place at the right time. J Cell Biochem. 1998 Aug 1; 70(2):200-12. PMID: 9671226.
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    368. Stein GS, van Wijnen AJ, Stein JL, Lian JB. Nuclear structure--skeletal gene expression interrelationships. Front Biosci. 1998; 3:d849-64. PMID: 9682039.
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    369. Ji C, Casinghino S, Chang DJ, Chen Y, Javed A, Ito Y, Hiebert SW, Lian JB, Stein GS, McCarthy TL, Centrella M. CBFa(AML/PEBP2)-related elements in the TGF-beta type I receptor promoter and expression with osteoblast differentiation. J Cell Biochem. 1998 Jun 1; 69(3):353-63. PMID: 9581873.
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    370. Lindenmuth D, van Wijnen AJ, Penman S, Stein JL, Stein GS, Lian JB. TGF-beta1 modifications in nuclear matrix proteins of osteoblasts during differentiation. J Cell Biochem. 1998 Jun 1; 69(3):291-303. PMID: 9581868.
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    371. Pei Y, Wang K, Kasenda M, Paterson AD, Liang Y, Huang E, Lian J, Rogovea E, Somlo S, St George-Hyslop P. A novel frameshift mutation induced by an adenosine insertion in the polycystic kidney disease 2 (PKD2) gene. Kidney Int. 1998 May; 53(5):1127-32. PMID: 9573526.
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    372. Shalhoub V, Aslam F, Breen E, van Wijnen A, Bortell R, Stein GS, Stein JL, Lian JB. Multiple levels of steroid hormone-dependent control of osteocalcin during osteoblast differentiation: glucocorticoid regulation of basal and vitamin D stimulated gene expression. J Cell Biochem. 1998 May 1; 69(2):154-68. PMID: 9548563.
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    373. Bodine PV, Henderson RA, Green J, Aronow M, Owen T, Stein GS, Lian JB, Komm BS. Estrogen receptor-alpha is developmentally regulated during osteoblast differentiation and contributes to selective responsiveness of gene expression. Endocrinology. 1998 Apr; 139(4):2048-57. PMID: 9528993.
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    374. Bodine PV, Henderson RA, Green J, Aronow M, Owen T, Stein GS, Lian JB, Komm BS. Estrogen Receptor-a Is Developmentally Regulated during Osteoblast Differentiation and Contributes to Selective Responsiveness of Gene Expression. Endocrinology. 1998 Apr 01; 139(4):2048-2057. PMID: 28200396.
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    375. McNeil S, Guo B, Stein JL, Lian JB, Bushmeyer S, Seto E, Atchison ML, Penman S, van Wijnen AJ, Stein GS. Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking. J Cell Biochem. 1998 Mar 15; 68(4):500-10. PMID: 9493912.
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    376. Zeng C, McNeil S, Pockwinse S, Nickerson J, Shopland L, Lawrence JB, Penman S, Hiebert S, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Intranuclear targeting of AML/CBFalpha regulatory factors to nuclear matrix-associated transcriptional domains. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1585-9. PMID: 9465059.
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    377. Lian JB, Stein GS, Stein JL, van Wijnen AJ. Transcriptional control of osteoblast differentiation. Biochem Soc Trans. 1998 Feb; 26(1):14-21. PMID: 10909750.
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    378. Aziz F, van Wijnen AJ, Vaughan PS, Wu S, Shakoori AR, Lian JB, Soprano KJ, Stein JL, Stein GS. The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes. Mol Biol Rep. 1998 Jan; 25(1):1-12. PMID: 9540062.
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    379. Stein GS, van Wijnen AJ, Stein JL, Lian JB, Pockwinse SM, McNeil S. Linkages of nuclear architecture to biological and pathological control of gene expression. J Cell Biochem Suppl. 1998; 30-31:220-31. PMID: 9893274.
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    380. Carulli JP, Artinger M, Swain PM, Root CD, Chee L, Tulig C, Guerin J, Osborne M, Stein G, Lian J, Lomedico PT. High throughput analysis of differential gene expression. J Cell Biochem Suppl. 1998; 30-31:286-96. PMID: 9893282.
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    381. Lynch MP, Capparelli C, Stein JL, Stein GS, Lian JB. Apoptosis during bone-like tissue development in vitro. J Cell Biochem. 1998 Jan 1; 68(1):31-49. PMID: 9407312.
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    382. Lian JB, Stein GS, Stein JL, van Wijnen AJ. Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation. J Cell Biochem Suppl. 1998; 30-31:62-72. PMID: 9893257.
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    383. Bagchi M, Ansari SA, Lindenmuth DM, van Wijnen AJ, Lian J, Stein JL, Stein GS. Nuclear matrix associated DNA-binding proteins of ocular lens epithelial cells. Mol Biol Rep. 1998 Jan; 25(1):13-9. PMID: 9540063.
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    384. Yang YB, Lian J, Tai PC. Differential translocation of protein precursors across SecY-deficient membranes of Escherichia coli: SecY is not obligatorily required for translocation of certain secretory proteins in vitro. J Bacteriol. 1997 Dec; 179(23):7386-93. PMID: 9393703.
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    385. Ryoo HM, Hoffmann HM, Beumer T, Frenkel B, Towler DA, Stein GS, Stein JL, van Wijnen AJ, Lian JB. Stage-specific expression of Dlx-5 during osteoblast differentiation: involvement in regulation of osteocalcin gene expression. Mol Endocrinol. 1997 Oct; 11(11):1681-94. PMID: 9328350.
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    386. van Wijnen AJ, Cooper C, Odgren P, Aziz F, De Luca A, Shakoori RA, Giordano A, Quesenberry PJ, Lian JB, Stein GS, Stein JL. Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells. J Cell Biochem. 1997 Sep 15; 66(4):512-23. PMID: 9282329.
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    387. Smith E, Frenkel B, MacLachlan TK, Giordano A, Stein JL, Lian JB, Stein GS. Post-proliferative cyclin E-associated kinase activity in differentiated osteoblasts: inhibition by proliferating osteoblasts and osteosarcoma cells. J Cell Biochem. 1997 Aug 1; 66(2):141-52. PMID: 9213216.
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    388. Stein GS, Lian JB, van Wijnen AJ, Stein JL. The osteocalcin gene: a model for multiple parameters of skeletal-specific transcriptional control. Mol Biol Rep. 1997 Aug; 24(3):185-96. PMID: 9291092.
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    389. Banerjee C, McCabe LR, Choi JY, Hiebert SW, Stein JL, Stein GS, Lian JB. Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex. J Cell Biochem. 1997 Jul 1; 66(1):1-8. PMID: 9215522.
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    390. Lucas TS, Bab IA, Lian JB, Stein GS, Jazrawi L, Majeska RJ, Attar-Namdar M, Einhorn TA. Stimulation of systemic bone formation induced by experimental blood loss. Clin Orthop Relat Res. 1997 Jul; (340):267-75. PMID: 9224265.
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    391. Lindenmuth DM, van Wijnen AJ, Hiebert S, Stein JL, Lian JB, Stein GS. Subcellular partitioning of transcription factors during osteoblast differentiation: developmental association of the AML/CBF alpha/PEBP2 alpha-related transcription factor-NMP-2 with the nuclear matrix. J Cell Biochem. 1997 Jul 1; 66(1):123-32. PMID: 9215534.
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    392. Zeng C, van Wijnen AJ, Stein JL, Meyers S, Sun W, Shopland L, Lawrence JB, Penman S, Lian JB, Stein GS, Hiebert SW. Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6746-51. PMID: 9192636.
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    393. Bodine PV, Green J, Harris HA, Bhat RA, Stein GS, Lian JB, Komm BS. Functional properties of a conditionally phenotypic, estrogen-responsive, human osteoblast cell line. J Cell Biochem. 1997 Jun 1; 65(3):368-87. PMID: 9138093.
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    394. Frenkel B, Capparelli C, Van Auken M, Baran D, Bryan J, Stein JL, Stein GS, Lian JB. Activity of the osteocalcin promoter in skeletal sites of transgenic mice and during osteoblast differentiation in bone marrow-derived stromal cell cultures: effects of age and sex. Endocrinology. 1997 May; 138(5):2109-16. PMID: 9112411.
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    395. Lian JB, Shalhoub V, Aslam F, Frenkel B, Green J, Hamrah M, Stein GS, Stein JL. Species-specific glucocorticoid and 1,25-dihydroxyvitamin D responsiveness in mouse MC3T3-E1 osteoblasts: dexamethasone inhibits osteoblast differentiation and vitamin D down-regulates osteocalcin gene expression. Endocrinology. 1997 May; 138(5):2117-27. PMID: 9112412.
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    396. Pockwinse SM, Krockmalnic G, Doxsey SJ, Nickerson J, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Penman S. Cell cycle independent interaction of CDC2 with the centrosome, which is associated with the nuclear matrix-intermediate filament scaffold. Proc Natl Acad Sci U S A. 1997 Apr 1; 94(7):3022-7. PMID: 9096339.
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    397. Guo B, Aslam F, van Wijnen AJ, Roberts SG, Frenkel B, Green MR, DeLuca H, Lian JB, Stein GS, Stein JL. YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene. Proc Natl Acad Sci U S A. 1997 Jan 7; 94(1):121-6. PMID: 8990171.
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    398. Ryoo HM, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Detection of a proliferation specific gene during development of the osteoblast phenotype by mRNA differential display. J Cell Biochem. 1997 Jan; 64(1):106-16. PMID: 9015759.
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    399. Staal A, van Wijnen AJ, Birkenhäger JC, Pols HA, Prahl J, DeLuca H, Gaub MP, Lian JB, Stein GS, van Leeuwen JP, Stein JL. Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes. Mol Endocrinol. 1996 Nov; 10(11):1444-56. PMID: 8923469.
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    400. Montecino M, Frenkel B, Lian J, Stein J, Stein G. Requirement of distal and proximal promoter sequences for chromatin organization of the osteocalcin gene in bone-derived cells. J Cell Biochem. 1996 Nov 1; 63(2):221-8. PMID: 8913873.
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    401. Lian JB. Mysterious cross talk between bone cells. J Clin Invest. 1996 Oct 15; 98(8):1697-8. PMID: 8878417.
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    402. McCabe LR, Banerjee C, Kundu R, Harrison RJ, Dobner PR, Stein JL, Lian JB, Stein GS. Developmental expression and activities of specific fos and jun proteins are functionally related to osteoblast maturation: role of Fra-2 and Jun D during differentiation. Endocrinology. 1996 Oct; 137(10):4398-408. PMID: 8828501.
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    403. Stein GS, Stein JL, Lian JB, van Wijnen AJ, Montecino M. Functional interrelationships between nuclear structure and transcriptional control: contributions to regulation of cell cycle- and tissue-specific gene expression. J Cell Biochem. 1996 Aug; 62(2):198-209. PMID: 8844400.
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    404. Banerjee C, Hiebert SW, Stein JL, Lian JB, Stein GS. An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4968-73. PMID: 8643513.
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    405. Banerjee C, Stein JL, Van Wijnen AJ, Frenkel B, Lian JB, Stein GS. Transforming growth factor-beta 1 responsiveness of the rat osteocalcin gene is mediated by an activator protein-1 binding site. Endocrinology. 1996 May; 137(5):1991-2000. PMID: 8612540.
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    406. Hoffmann HM, Beumer TL, Rahman S, McCabe LR, Banerjee C, Aslam F, Tiro JA, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Bone tissue-specific transcription of the osteocalcin gene: role of an activator osteoblast-specific complex and suppressor hox proteins that bind the OC box. J Cell Biochem. 1996 May; 61(2):310-24. PMID: 9173094.
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    407. Staal A, Van Wijnen AJ, Desai RK, Pols HA, Birkenhäger JC, Deluca HF, Denhardt DT, Stein JL, Van Leeuwen JP, Stein GS, Lian JB. Antagonistic effects of transforming growth factor-beta on vitamin D3 enhancement of osteocalcin and osteopontin transcription: reduced interactions of vitamin D receptor/retinoid X receptor complexes with vitamin E response elements. Endocrinology. 1996 May; 137(5):2001-11. PMID: 8612541.
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    408. Montecino M, Lian J, Stein G, Stein J. Changes in chromatin structure support constitutive and developmentally regulated transcription of the bone-specific osteocalcin gene in osteoblastic cells. Biochemistry. 1996 Apr 16; 35(15):5093-102. PMID: 8664302.
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    409. Tang KT, Capparelli C, Stein JL, Stein GS, Lian JB, Huber AC, Braverman LE, DeVito WJ. Acidic fibroblast growth factor inhibits osteoblast differentiation in vitro: altered expression of collagenase, cell growth-related, and mineralization-associated genes. J Cell Biochem. 1996 Apr; 61(1):152-66. PMID: 8726364.
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    410. Stein GS, Lian JB, Stein JL, Van Wijnen AJ, Montecino M. Transcriptional control of osteoblast growth and differentiation. Physiol Rev. 1996 Apr; 76(2):593-629. PMID: 8618964.
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    411. Frenkel B, Montecino M, Green J, Aslam F, Desai R, Banerjee C, Stein JL, Lian JB, Stein GS. Basal and vitamin D-responsive activity of the rat osteocalcin promoter in stably transfected osteosarcoma cells: requirement of upstream sequences for control by the proximal regulatory domain. Endocrinology. 1996 Mar; 137(3):1080-88. PMID: 8603577.
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    412. Stein JL, van Wijnen AJ, Lian JB, Stein GS. Control of cell cycle regulated histone genes during proliferation and differentiation. Int J Obes Relat Metab Disord. 1996 Mar; 20 Suppl 3:S84-90. PMID: 8680483.
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    413. Shalhoub V, Jackson ME, Paradise C, Stein GS, Lian JB, Marks SC. Heterogeneity of colony stimulating factor-1 gene expression in the skeleton of four osteopetrotic mutations in rats and mice. J Cell Physiol. 1996 Feb; 166(2):340-50. PMID: 8591994.
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    414. Stein GS, Stein JL, Van Wijnen AJ, Lian JB. Transcriptional control of cell cycle progression: the histone gene is a paradigm for the G1/S phase and proliferation/differentiation transitions. Cell Biol Int. 1996 Jan; 20(1):41-9. PMID: 8936406.
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    415. Lian JB, Stein GS, Stein JL, Van Wijnen A, McCabe L, Banerjee C, Hoffmann H. The osteocalcin gene promoter provides a molecular blueprint for regulatory mechanisms controlling bone tissue formation: role of transcription factors involved in development. Connect Tissue Res. 1996; 35(1-4):15-21. PMID: 9084639.
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    416. Desai RK, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Control of 1,25-dihydroxyvitamin D3 receptor-mediated enhancement of osteocalcin gene transcription: effects of perturbing phosphorylation pathways by okadaic acid and staurosporine. Endocrinology. 1995 Dec; 136(12):5685-93. PMID: 7588324.
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    417. Guo B, Odgren PR, van Wijnen AJ, Last TJ, Nickerson J, Penman S, Lian JB, Stein JL, Stein GS. The nuclear matrix protein NMP-1 is the transcription factor YY1. Proc Natl Acad Sci U S A. 1995 Nov 7; 92(23):10526-30. PMID: 7479833.
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    418. Shakoori AR, van Wijnen AJ, Cooper C, Aziz F, Birnbaum M, Reddy GP, Grana X, De Luca A, Giordano A, Lian JB, et al. Cytokine induction of proliferation and expression of CDC2 and cyclin A in FDC-P1 myeloid hematopoietic progenitor cells: regulation of ubiquitous and cell cycle-dependent histone gene transcription factors. J Cell Biochem. 1995 Nov; 59(3):291-302. PMID: 8567748.
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    419. Smith E, Frenkel B, Schlegel R, Giordano A, Lian JB, Stein JL, Stein GS. Expression of cell cycle regulatory factors in differentiating osteoblasts: postproliferative up-regulation of cyclins B and E. Cancer Res. 1995 Nov 1; 55(21):5019-24. PMID: 7585545.
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    420. Merriman HL, van Wijnen AJ, Hiebert S, Bidwell JP, Fey E, Lian J, Stein J, Stein GS. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family: interactions with the osteocalcin gene promoter. Biochemistry. 1995 Oct 10; 34(40):13125-32. PMID: 7548073.
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    421. Stein GS, Stein JL, van Wijnen A, Lian JB, Quesenberry PJ. Molecular mechanisms mediating control of cell cycle and cell growth. Exp Hematol. 1995 Sep; 23(10):1053-61. PMID: 7656927.
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    422. Aslam F, Shalhoub V, van Wijnen AJ, Banerjee C, Bortell R, Shakoori AR, Litwack G, Stein JL, Stein GS, Lian JB. Contributions of distal and proximal promoter elements to glucocorticoid regulation of osteocalcin gene transcription. Mol Endocrinol. 1995 Jun; 9(6):679-90. PMID: 8592514.
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    423. McCabe LR, Kockx M, Lian J, Stein J, Stein G. Selective expression of fos- and jun-related genes during osteoblast proliferation and differentiation. Exp Cell Res. 1995 May; 218(1):255-62. PMID: 7737363.
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    424. Bagchi M, Van Wijnen A, Katar M, Merriman H, Lian J, Stein J, Stein G, Maisel H. Sequence-specific DNA binding activities of nuclear matrix proteins of mammalian lens epithelial cells. J Cell Biochem. 1995 May; 58(1):1-5. PMID: 7642716.
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    425. Menconi MJ, Pockwinse S, Owen TA, Dasse KA, Stein GS, Lian JB. Properties of blood-contacting surfaces of clinically implanted cardiac assist devices: gene expression, matrix composition, and ultrastructural characterization of cellular linings. J Cell Biochem. 1995 Mar; 57(3):557-73. PMID: 7768989.
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    426. Lian JB, Stein GS. Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation. Iowa Orthop J. 1995; 15:118-40. PMID: 7634023.
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    427. Heinrichs AA, Bortell R, Bourke M, Lian JB, Stein GS, Stein JL. Proximal promoter binding protein contributes to developmental, tissue-restricted expression of the rat osteocalcin gene. J Cell Biochem. 1995 Jan; 57(1):90-100. PMID: 7721961.
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    428. Stein GS, van Wijnen AJ, Stein J, Lian JB, Montecino M. Contributions of nuclear architecture to transcriptional control. Int Rev Cytol. 1995; 162A:251-78. PMID: 8575882.
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    429. Lynch MP, Stein JL, Stein GS, Lian JB. The influence of type I collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization. Exp Cell Res. 1995 Jan; 216(1):35-45. PMID: 7813631.
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    430. Pockwinse SM, Stein JL, Lian JB, Stein GS. Developmental stage-specific cellular responses to vitamin D and glucocorticoids during differentiation of the osteoblast phenotype: interrelationship of morphology and gene expression by in situ hybridization. Exp Cell Res. 1995 Jan; 216(1):244-60. PMID: 7813627.
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    431. van Wijnen AJ, Aziz F, Graña X, De Luca A, Desai RK, Jaarsveld K, Last TJ, Soprano K, Giordano A, Lian JB, et al. Transcription of histone H4, H3, and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-related protein. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12882-6. PMID: 7809140.
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    432. Breen EC, van Wijnen AJ, Lian JB, Stein GS, Stein JL. In vivo occupancy of the vitamin D responsive element in the osteocalcin gene supports vitamin D-dependent transcriptional upregulation in intact cells. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12902-6. PMID: 7809144.
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    433. Hoffmann HM, Catron KM, van Wijnen AJ, McCabe LR, Lian JB, Stein GS, Stein JL. Transcriptional control of the tissue-specific, developmentally regulated osteocalcin gene requires a binding motif for the Msx family of homeodomain proteins. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12887-91. PMID: 7809141.
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    434. Foster RG, Lian JB, Stein G, Robinson HL. Replication of an osteopetrosis-inducing avian leukosis virus in fibroblasts, osteoblasts, and osteopetrotic bone. Virology. 1994 Nov 15; 205(1):179-87. PMID: 7975214.
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    435. Frenkel B, Montecino M, Stein JL, Lian JB, Stein GS. A composite intragenic silencer domain exhibits negative and positive transcriptional control of the bone-specific osteocalcin gene: promoter and cell type requirements. Proc Natl Acad Sci U S A. 1994 Nov 8; 91(23):10923-7. PMID: 7971985.
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    436. McCabe LR, Last TJ, Lynch M, Lian J, Stein J, Stein G. Expression of cell growth and bone phenotypic genes during the cell cycle of normal diploid osteoblasts and osteosarcoma cells. J Cell Biochem. 1994 Oct; 56(2):274-82. PMID: 7829587.
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    437. Garcia JH, Liu KF, Yoshida Y, Chen S, Lian J. Brain microvessels: factors altering their patency after the occlusion of a middle cerebral artery (Wistar rat). Am J Pathol. 1994 Sep; 145(3):728-40. PMID: 8080052.
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    438. Barone LM, Aronow MA, Tassinari MS, Conlon D, Canalis E, Stein GS, Lian JB. Differential effects of warfarin on mRNA levels of developmentally regulated vitamin K dependent proteins, osteocalcin, and matrix GLA protein in vitro. J Cell Physiol. 1994 Aug; 160(2):255-64. PMID: 8040186.
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    439. Breen EC, Ignotz RA, McCabe L, Stein JL, Stein GS, Lian JB. TGF beta alters growth and differentiation related gene expression in proliferating osteoblasts in vitro, preventing development of the mature bone phenotype. J Cell Physiol. 1994 Aug; 160(2):323-35. PMID: 8040190.
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    440. Jackson ME, Shalhoub V, Lian JB, Stein GS, Marks SC. Aberrant gene expression in cultured mammalian bone cells demonstrates an osteoblast defect in osteopetrosis. J Cell Biochem. 1994 Jul; 55(3):366-72. PMID: 7962169.
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    441. Bollerslev J, Marks SC, Mosekilde L, Lian JB, Stein GS, Mosekilde L. Cortical bone osteocalcin content and matrix composition in autosomal dominant osteopetrosis type I. Eur J Endocrinol. 1994 Jun; 130(6):592-4. PMID: 8205260.
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    442. van den Ent FM, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Cell cycle controlled histone H1, H3, and H4 genes share unusual arrangements of recognition motifs for HiNF-D supporting a coordinate promoter binding mechanism. J Cell Physiol. 1994 Jun; 159(3):515-30. PMID: 8188766.
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    443. Shakoori AR, van Wijnen AJ, Bortell R, Owen TA, Stein JL, Lian JB, Stein GS. Variations in vitamin D receptor transcription factor complexes associated with the osteocalcin gene vitamin D responsive element in osteoblasts and osteosarcoma cells. J Cell Biochem. 1994 Jun; 55(2):218-29. PMID: 8089197.
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    444. Shalhoub V, Bortell R, Jackson ME, Marks SC, Stein JL, Lian JB, Stein GS. Transcriptionally active nuclei isolated from intact bone reflect modified levels of gene expression in skeletal development and pathology. J Cell Biochem. 1994 Jun; 55(2):182-9. PMID: 8089193.
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    445. Liggett WH, Lian JB, Greenberger JS, Glowacki J. Osteocalcin promotes differentiation of osteoclast progenitors from murine long-term bone marrow cultures. J Cell Biochem. 1994 Jun; 55(2):190-9. PMID: 8089194.
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    446. Jenis LG, Ongphiphadhanakul B, Braverman LE, Stein GS, Lian JB, Lew R, Baran DT. Responsiveness of gene expression markers of osteoblastic and osteoclastic activity to calcitonin in the appendicular and axial skeleton of the rat in vivo. Calcif Tissue Int. 1994 Jun; 54(6):511-5. PMID: 8082057.
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    447. Stein GS, van Wijnen AJ, Stein JL, Lian JB, Bidwell JP, Montecino M. Nuclear architecture supports integration of physiological regulatory signals for transcription of cell growth and tissue-specific genes during osteoblast differentiation. J Cell Biochem. 1994 May; 55(1):4-15. PMID: 8083299.
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    448. Bidwell JP, van Wijnen AJ, Fey EG, Merriman H, Penman S, Stein JL, Stein GS, Lian JB. Subnuclear distribution of the vitamin D receptor. J Cell Biochem. 1994 Apr; 54(4):494-500. PMID: 8014199.
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    449. Stein GS, Stein JL, van Wijnen AJ, Lian JB. Histone gene transcription: a model for responsiveness to an integrated series of regulatory signals mediating cell cycle control and proliferation/differentiation interrelationships. J Cell Biochem. 1994 Apr; 54(4):393-404. PMID: 8014188.
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    450. Bidwell J, van Wijnen A, Banerjee C, Fey E, Merriman H, Penman S, Stein J, Lian J, Stein G. Parathyroid-responsive modifications in the nuclear matrix of ROS 17/2.8 rat osteosarcoma cells. Endocrinology. 1994 Apr; 134(4):1738-44. PMID: 8137738.
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    451. Briggs R, Dworkin L, Briggs J, Dessypris E, Stein J, Stein G, Lian J. Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage. J Cell Biochem. 1994 Feb; 54(2):198-206. PMID: 8175894.
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    452. Gierthy JF, Silkworth JB, Tassinari M, Stein GS, Lian JB. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits differentiation of normal diploid rat osteoblasts in vitro. J Cell Biochem. 1994 Feb; 54(2):231-8. PMID: 8175897.
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    453. Montecino M, Pockwinse S, Lian J, Stein G, Stein J. DNase I hypersensitive sites in promoter elements associated with basal and vitamin D dependent transcription of the bone-specific osteocalcin gene. Biochemistry. 1994 Jan 11; 33(1):348-53. PMID: 8286356.
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    454. Shalhoub V, Bettencourt B, Jackson ME, MacKay CA, Glimcher MJ, Marks SC, Stein GS, Lian JB. Abnormalities of phosphoprotein gene expression in three osteopetrotic rat mutations: elevated mRNA transcripts, protein synthesis, and accumulation in bone of mutant animals. J Cell Physiol. 1994 Jan; 158(1):110-20. PMID: 8263018.
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    455. Kockx M, McCabe L, Stein JL, Lian JB, Stein GS. Influence of DNA replication inhibition on expression of cell growth and tissue-specific genes in osteoblasts and osteosarcoma cells. J Cell Biochem. 1994 Jan; 54(1):47-55. PMID: 8126086.
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    456. Garcia JH, Liu KF, Yoshida Y, Lian J, Chen S, del Zoppo GJ. Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat). Am J Pathol. 1994 Jan; 144(1):188-99. PMID: 8291608.
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    457. Bidwell JP, Fey EG, van Wijnen AJ, Penman S, Stein JL, Lian JB, Stein GS. Nuclear matrix proteins distinguish normal diploid osteoblasts from osteosarcoma cells. Cancer Res. 1994 Jan 1; 54(1):28-32. PMID: 8261453.
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    458. Frenkel B, Mijnes J, Aronow MA, Zambetti G, Banerjee C, Stein JL, Lian JB, Stein GS. Position and orientation-selective silencer in protein-coding sequences of the rat osteocalcin gene. Biochemistry. 1993 Dec 14; 32(49):13636-43. PMID: 7504955.
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    459. Ongphiphadhanakul B, Jenis LG, Braverman LE, Alex S, Stein GS, Lian JB, Baran DT. Etidronate inhibits the thyroid hormone-induced bone loss in rats assessed by bone mineral density and messenger ribonucleic acid markers of osteoblast and osteoclast function. Endocrinology. 1993 Dec; 133(6):2502-7. PMID: 8243271.
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    460. Rahman S, Oberdorf A, Montecino M, Tanhauser SM, Lian JB, Stein GS, Laipis PJ, Stein JL. Multiple copies of the bone-specific osteocalcin gene in mouse and rat. Endocrinology. 1993 Dec; 133(6):3050-3. PMID: 8243336.
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    461. Heinrichs AA, Banerjee C, Bortell R, Owen TA, Stein JL, Stein GS, Lian JB. Identification and characterization of two proximal elements in the rat osteocalcin gene promoter that may confer species-specific regulation. J Cell Biochem. 1993 Nov; 53(3):240-50. PMID: 8263041.
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    462. Jenis LG, Lian JB, Stein GS, Baran DT. 1 alpha,25-dihydroxyvitamin D3-induced changes in intracellular pH in osteoblast-like cells modulate gene expression. J Cell Biochem. 1993 Nov; 53(3):234-9. PMID: 8263040.
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    463. Heinrichs AA, Bortell R, Rahman S, Stein JL, Alnemri ES, Litwack G, Lian JB, Stein GS. Identification of multiple glucocorticoid receptor binding sites in the rat osteocalcin gene promoter. Biochemistry. 1993 Oct 26; 32(42):11436-44. PMID: 8218210.
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    464. van Wijnen AJ, Bidwell JP, Fey EG, Penman S, Lian JB, Stein JL, Stein GS. Nuclear matrix association of multiple sequence-specific DNA binding activities related to SP-1, ATF, CCAAT, C/EBP, OCT-1, and AP-1. Biochemistry. 1993 Aug 24; 32(33):8397-402. PMID: 8357791.
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    465. Stein GS, Lian JB. Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr Rev. 1993 Aug; 14(4):424-42. PMID: 8223340.
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    466. Jenis LG, Waud CE, Stein GS, Lian JB, Baran DT. Effect of gallium nitrate in vitro and in normal rats. J Cell Biochem. 1993 Jul; 52(3):330-6. PMID: 8366144.
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    467. Barone LM, Tassinari MS, Bortell R, Owen TA, Zerogian J, Gagne K, Stein GS, Lian JB. Inhibition of induced endochondral bone development in caffeine-treated rats. J Cell Biochem. 1993 Jun; 52(2):171-82. PMID: 8366135.
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    468. Lian JB, McKee MD, Todd AM, Gerstenfeld LC. Induction of bone-related proteins, osteocalcin and osteopontin, and their matrix ultrastructural localization with development of chondrocyte hypertrophy in vitro. J Cell Biochem. 1993 Jun; 52(2):206-19. PMID: 8366137.
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    469. van den Ent FM, van Wijnen AJ, Last TJ, Bortell R, Stein JL, Lian JB, Stein GS. Concerted control of multiple histone promoter factors during cell density inhibition of proliferation in osteosarcoma cells: reciprocal regulation of cell cycle-controlled and bone-related genes. Cancer Res. 1993 May 15; 53(10 Suppl):2399-409. PMID: 8485727.
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    470. Pockwinse SM, Lawrence JB, Singer RH, Stein JL, Lian JB, Stein GS. Gene expression at single cell resolution associated with development of the bone cell phenotype: ultrastructural and in situ hybridization analysis. Bone. 1993 May-Jun; 14(3):347-52. PMID: 8363877.
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    471. Bidwell JP, Van Wijnen AJ, Fey EG, Dworetzky S, Penman S, Stein JL, Lian JB, Stein GS. Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix components. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3162-6. PMID: 8475055.
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    472. Shakoori AR, Owen TA, Shalhoub V, Stein JL, Bustin M, Stein GS, Lian JB. Differential expression of the chromosomal high mobility group proteins 14 and 17 during the onset of differentiation in mammalian osteoblasts and promyelocytic leukemia cells. J Cell Biochem. 1993 Apr; 51(4):479-87. PMID: 8496248.
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    473. Bortell R, Owen TA, Shalhoub V, Heinrichs A, Aronow MA, Rochette-Egly C, Lutz Y, Stein JL, Lian JB, Stein GS. Constitutive transcription of the osteocalcin gene in osteosarcoma cells is reflected by altered protein-DNA interactions at promoter regulatory elements. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2300-4. PMID: 8460137.
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    474. Owen TA, Bortell R, Shalhoub V, Heinrichs A, Stein JL, Stein GS, Lian JB. Postproliferative transcription of the rat osteocalcin gene is reflected by vitamin D-responsive developmental modifications in protein-DNA interactions at basal and enhancer promoter elements. Proc Natl Acad Sci U S A. 1993 Feb 15; 90(4):1503-7. PMID: 8381969.
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    475. Garcia JH, Yoshida Y, Chen H, Li Y, Zhang ZG, Lian J, Chen S, Chopp M. Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am J Pathol. 1993 Feb; 142(2):623-35. PMID: 8434652.
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    476. Lian JB, Stein GS. The developmental stages of osteoblast growth and differentiation exhibit selective responses of genes to growth factors (TGF beta 1) and hormones (vitamin D and glucocorticoids). J Oral Implantol. 1993; 19(2):95-105; discussion 136-7. PMID: 8246305.
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    477. Shalhoub V, Conlon D, Tassinari M, Quinn C, Partridge N, Stein GS, Lian JB. Glucocorticoids promote development of the osteoblast phenotype by selectively modulating expression of cell growth and differentiation associated genes. J Cell Biochem. 1992 Dec; 50(4):425-40. PMID: 1469073.
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    478. Collart D, Romain PL, Huebner K, Pockwinse S, Pilapil S, Cannizzaro LA, Lian JB, Croce CM, Stein JL, Stein GS. A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing. J Cell Biochem. 1992 Dec; 50(4):374-85. PMID: 1469070.
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    479. Chanoine JP, Stein GS, Braverman LE, Shalhoub V, Lian JB, Huber CA, DeVito WJ. Acidic fibroblast growth factor modulates gene expression in the rat thyroid in vivo. J Cell Biochem. 1992 Dec; 50(4):392-9. PMID: 1281822.
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    480. Boskey AL, Rimnac CM, Bansal M, Federman M, Lian J, Boyan BD. Effect of short-term hypomagnesemia on the chemical and mechanical properties of rat bone. J Orthop Res. 1992 Nov; 10(6):774-83. PMID: 1403290.
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    481. Baran DT, Sorensen AM, Shalhoub V, Owen T, Stein G, Lian J. The rapid nongenomic actions of 1 alpha,25-dihydroxyvitamin D3 modulate the hormone-induced increments in osteocalcin gene transcription in osteoblast-like cells. J Cell Biochem. 1992 Oct; 50(2):124-9. PMID: 1429879.
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    482. Rabinovitz M, Shapiro J, Lian J, Block GD, Merkel IS, Van Thiel DH. Vitamin D and osteocalcin levels in liver transplant recipients. Is osteocalcin a reliable marker of bone turnover in such cases? J Hepatol. 1992 Sep; 16(1-2):50-5. PMID: 1484167.
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    483. De Vito WJ, Chanoine JP, Alex S, Fang SL, Stone S, Huber CA, Shalhoub V, Lian JB, Stein GS, Braverman LE. Effect of in vivo administration of recombinant acidic fibroblast growth factor on thyroid function in the rat: induction of colloid goiter. Endocrinology. 1992 Aug; 131(2):729-35. PMID: 1379163.
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    484. Pockwinse SM, Wilming LG, Conlon DM, Stein GS, Lian JB. Expression of cell growth and bone specific genes at single cell resolution during development of bone tissue-like organization in primary osteoblast cultures. J Cell Biochem. 1992 Jul; 49(3):310-23. PMID: 1644867.
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    485. Defranco DJ, Lian JB, Glowacki J. Differential effects of glucocorticoid on recruitment and activity of osteoclasts induced by normal and osteocalcin-deficient bone implanted in rats. Endocrinology. 1992 Jul; 131(1):114-21. PMID: 1611989.
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    486. van Wijnen AJ, van den Ent FM, Lian JB, Stein JL, Stein GS. Overlapping and CpG methylation-sensitive protein-DNA interactions at the histone H4 transcriptional cell cycle domain: distinctions between two human H4 gene promoters. Mol Cell Biol. 1992 Jul; 12(7):3273-87. PMID: 1620129.
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    487. Bortell R, Owen TA, Bidwell JP, Gavazzo P, Breen E, van Wijnen AJ, DeLuca HF, Stein JL, Lian JB, Stein GS. Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression. Proc Natl Acad Sci U S A. 1992 Jul 1; 89(13):6119-23. PMID: 1321435.
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    488. Gerbaulet SP, van Wijnen AJ, Aronin N, Tassinari MS, Lian JB, Stein JL, Stein GS. Downregulation of histone H4 gene transcription during postnatal development in transgenic mice and at the onset of differentiation in transgenically derived calvarial osteoblast cultures. J Cell Biochem. 1992 Jun; 49(2):137-47. PMID: 1400621.
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    489. Menconi MJ, Owen T, Dasse KA, Stein G, Lian JB. Molecular approaches to the characterization of cell and blood/biomaterial interactions. J Card Surg. 1992 Jun; 7(2):177-87. PMID: 1606370.
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    490. Lian JB, Stein GS. Transcriptional control of vitamin D-regulated proteins. J Cell Biochem. 1992 May; 49(1):37-45. PMID: 1644852.
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    491. van der Houven van Oordt CW, van Wijnen AJ, Carter R, Soprano K, Lian JB, Stein GS, Stein JL. Protein-DNA interactions at the H4-site III upstream transcriptional element of a cell cycle regulated histone H4 gene: differences in normal versus tumor cells. J Cell Biochem. 1992 May; 49(1):93-110. PMID: 1644858.
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    492. Dworetzky SI, Wright KL, Fey EG, Penman S, Lian JB, Stein JL, Stein GS. Sequence-specific DNA-binding proteins are components of a nuclear matrix-attachment site. Proc Natl Acad Sci U S A. 1992 May 1; 89(9):4178-82. PMID: 1570345.
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    493. Stein GS, Stein JL, van Wijnen AJ, Lian JB. Regulation of histone gene expression. Curr Opin Cell Biol. 1992 Apr; 4(2):166-73. PMID: 1599687.
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    494. van Wijnen AJ, Bidwell J, Lian JB, Stein JL, Stein GS. Stairway assays: rapid localization of multiple protein/DNA interaction sites in gene-regulatory 5' regions. Biotechniques. 1992 Mar; 12(3):400-7. PMID: 1571151.
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    495. Shakoori AR, Oberdorf AM, Owen TA, Weber LA, Hickey E, Stein JL, Lian JB, Stein GS. Expression of heat shock genes during differentiation of mammalian osteoblasts and promyelocytic leukemia cells. J Cell Biochem. 1992 Mar; 48(3):277-87. PMID: 1400614.
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    496. Lian JB, Stein GS. Concepts of osteoblast growth and differentiation: basis for modulation of bone cell development and tissue formation. Crit Rev Oral Biol Med. 1992; 3(3):269-305. PMID: 1571474.
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    497. Stein GS, Lian JB. Regulation of cell cycle and growth control. Bioelectromagnetics. 1992; Suppl 1:247-65. PMID: 1285719.
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    498. van Wijnen AJ, Lian JB, Stein JL, Stein GS. Protein/DNA interactions involving ATF/AP1-, CCAAT-, and HiNF-D-related factors in the human H3-ST519 histone promoter: cross-competition with transcription regulatory sites in cell cycle controlled H4 and H1 histone genes. J Cell Biochem. 1991 Dec; 47(4):337-51. PMID: 1795016.
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    499. Baran DT, Sorensen AM, Shalhoub V, Owen T, Oberdorf A, Stein G, Lian J. 1 Alpha,25-dihydroxyvitamin D3 rapidly increases cytosolic calcium in clonal rat osteosarcoma cells lacking the vitamin D receptor. J Bone Miner Res. 1991 Dec; 6(12):1269-75. PMID: 1665280.
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    500. Stein GS, Lian JB, Dworetzky SI, Owen TA, Bortell R, Bidwell JP, van Wijnen AJ. Regulation of transcription-factor activity during growth and differentiation: involvement of the nuclear matrix in concentration and localization of promoter binding proteins. J Cell Biochem. 1991 Dec; 47(4):300-5. PMID: 1795014.
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    501. Tassinari MS, Gerstenfeld LC, Stein GS, Lian JB. Effect of caffeine on parameters of osteoblast growth and differentiation of a mineralized extracellular matrix in vitro. J Bone Miner Res. 1991 Oct; 6(10):1029-36. PMID: 1796750.
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    502. Schepmoes G, Breen E, Owen TA, Aronow MA, Stein GS, Lian JB. Influence of dexamethasone on the vitamin D-mediated regulation of osteocalcin gene expression. J Cell Biochem. 1991 Oct; 47(2):184-96. PMID: 1757481.
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    503. Barone LM, Owen TA, Tassinari MS, Bortell R, Stein GS, Lian JB. Developmental expression and hormonal regulation of the rat matrix Gla protein (MGP) gene in chondrogenesis and osteogenesis. J Cell Biochem. 1991 Aug; 46(4):351-65. PMID: 1757478.
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    504. van Wijnen AJ, Owen TA, Holthuis J, Lian JB, Stein JL, Stein GS. Coordination of protein-DNA interactions in the promoters of human H4, H3, and H1 histone genes during the cell cycle, tumorigenesis, and development. J Cell Physiol. 1991 Jul; 148(1):174-89. PMID: 1860895.
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    505. DeFranco DJ, Glowacki J, Cox KA, Lian JB. Normal bone particles are preferentially resorbed in the presence of osteocalcin-deficient bone particles in vivo. Calcif Tissue Int. 1991 Jul; 49(1):43-50. PMID: 1893294.
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    506. van Wijnen AJ, Ramsey-Ewing AL, Bortell R, Owen TA, Lian JB, Stein JL, Stein GS. Transcriptional element H4-site II of cell cycle regulated human H4 histone genes is a multipartite protein/DNA interaction site for factors HiNF-D, HiNF-M, and HiNF-P: involvement of phosphorylation. J Cell Biochem. 1991 Jun; 46(2):174-89. PMID: 1655821.
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    507. Shalhoub V, Jackson ME, Lian JB, Stein GS, Marks SC. Gene expression during skeletal development in three osteopetrotic rat mutations. Evidence for osteoblast abnormalities. J Biol Chem. 1991 May 25; 266(15):9847-56. PMID: 2033073.
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    508. van Wijnen AJ, Choi TK, Owen TA, Wright KL, Lian JB, Jaenisch R, Stein JL, Stein GS. Involvement of the cell cycle-regulated nuclear factor HiNF-D in cell growth control of a human H4 histone gene during hepatic development in transgenic mice. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2573-7. PMID: 2006193.
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    509. Owen TA, Aronow MS, Barone LM, Bettencourt B, Stein GS, Lian JB. Pleiotropic effects of vitamin D on osteoblast gene expression are related to the proliferative and differentiated state of the bone cell phenotype: dependency upon basal levels of gene expression, duration of exposure, and bone matrix competency in normal rat osteoblast cultures. Endocrinology. 1991 Mar; 128(3):1496-504. PMID: 1999168.
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    510. Glowacki J, Rey C, Glimcher MJ, Cox KA, Lian J. A role for osteocalcin in osteoclast differentiation. J Cell Biochem. 1991 Mar; 45(3):292-302. PMID: 2066381.
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    511. Collart D, Ramsey-Ewing A, Bortell R, Lian J, Stein J, Stein G. Isolation and characterization of a cDNA from a human histone H2B gene which is reciprocally expressed in relation to replication-dependent H2B histone genes during HL60 cell differentiation. Biochemistry. 1991 Feb 12; 30(6):1610-7. PMID: 1993178.
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    512. Peng TC, Lian JB, Hirsch PF, Kusy RP. Lower serum osteocalcin in ethanol-fed rats. J Bone Miner Res. 1991 Feb; 6(2):107-15. PMID: 2028832.
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    513. Lian JB, Stein GS, Bortell R, Owen TA. Phenotype suppression: a postulated molecular mechanism for mediating the relationship of proliferation and differentiation by Fos/Jun interactions at AP-1 sites in steroid responsive promoter elements of tissue-specific genes. J Cell Biochem. 1991 Jan; 45(1):9-14. PMID: 1900844.
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    514. Stein GS, Lian JB, Owen TA. Bone cell differentiation: a functionally coupled relationship between expression of cell-growth- and tissue-specific genes. Curr Opin Cell Biol. 1990 Dec; 2(6):1018-27. PMID: 2099795.
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    515. Stein GS, Lian JB, Owen TA. Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB J. 1990 Oct; 4(13):3111-23. PMID: 2210157.
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    516. Bortell R, Barone LM, Tassinari MS, Lian JB, Stein GS. Gene expression during endochondral bone development: evidence for coordinate expression of transforming growth factor beta 1 and collagen type I. J Cell Biochem. 1990 Oct; 44(2):81-91. PMID: 2250045.
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    517. Feteih R, Tassinari MS, Lian JB. Effect of sodium warfarin on vitamin K-dependent proteins and skeletal development in the rat fetus. J Bone Miner Res. 1990 Aug; 5(8):885-94. PMID: 2239372.
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    518. Owen TA, Holthuis J, Markose E, van Wijnen AJ, Wolfe SA, Grimes SR, Lian JB, Stein GS. Modifications of protein-DNA interactions in the proximal promoter of a cell-growth-regulated histone gene during onset and progression of osteoblast differentiation. Proc Natl Acad Sci U S A. 1990 Jul; 87(13):5129-33. PMID: 2367528.
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    519. Owen TA, Aronow M, Shalhoub V, Barone LM, Wilming L, Tassinari MS, Kennedy MB, Pockwinse S, Lian JB, Stein GS. Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol. 1990 Jun; 143(3):420-30. PMID: 1694181.
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    520. Tian H, Lian J, Zhang X. [Glycosylated hemoglobin in the diagnosis of diabetes mellitus]. Hua Xi Yi Ke Da Xue Xue Bao. 1990 Jun; 21(2):197-200. PMID: 2391104.
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    521. Dworetzky SI, Fey EG, Penman S, Lian JB, Stein JL, Stein GS. Progressive changes in the protein composition of the nuclear matrix during rat osteoblast differentiation. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4605-9. PMID: 2352938.
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    522. Aronow MA, Gerstenfeld LC, Owen TA, Tassinari MS, Stein GS, Lian JB. Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells. J Cell Physiol. 1990 May; 143(2):213-21. PMID: 2332447.
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    523. Holthuis J, Owen TA, van Wijnen AJ, Wright KL, Ramsey-Ewing A, Kennedy MB, Carter R, Cosenza SC, Soprano KJ, Lian JB, et al. Tumor cells exhibit deregulation of the cell cycle histone gene promoter factor HiNF-D. Science. 1990 Mar 23; 247(4949 Pt 1):1454-7. PMID: 2321007.
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    524. Markose ER, Stein JL, Stein GS, Lian JB. Vitamin D-mediated modifications in protein-DNA interactions at two promoter elements of the osteocalcin gene. Proc Natl Acad Sci U S A. 1990 Mar; 87(5):1701-5. PMID: 2308930.
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    525. Gerstenfeld LC, Kelly CM, Von Deck M, Lian JB. Effect of 1,25-dihydroxyvitamin D3 on induction of chondrocyte maturation in culture: extracellular matrix gene expression and morphology. Endocrinology. 1990 Mar; 126(3):1599-609. PMID: 2307121.
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    526. Gaczynski M, Briggs JA, Wedrychowski A, Olinski R, Uskokovic M, Lian JB, Stein GS, Briggs RC. cis-diamminedichloroplatinum(II) cross-linking of the human myeloid cell nuclear differentiation antigen to DNA in HL-60 cells following 1,25-dihydroxy vitamin D3-induced monocyte differentiation. Cancer Res. 1990 Feb 15; 50(4):1183-8. PMID: 2297767.
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    527. Lian JB, Marks SC. Osteopetrosis in the rat: coexistence of reductions in osteocalcin and bone resorption. Endocrinology. 1990 Feb; 126(2):955-62. PMID: 2298176.
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    528. Gerstenfeld LC, Kelly CM, Von Deck M, Lian JB. Comparative morphological and biochemical analysis of hypertrophic, non-hypertrophic and 1,25(OH)2D3 treated non-hypertrophic chondrocytes. Connect Tissue Res. 1990; 24(1):29-39. PMID: 1692522.
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    529. Boivin G, Morel G, Lian JB, Anthoine-Terrier C, Dubois PM, Meunier PJ. Localization of endogenous osteocalcin in neonatal rat bone and its absence in articular cartilage: effect of warfarin treatment. Virchows Arch A Pathol Anat Histopathol. 1990; 417(6):505-12. PMID: 2125389.
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    530. Stein GS, Stein JL, Lian JB, Van Wijnen AJ, Wright KL, Pauli U. Modifications in molecular mechanisms associated with control of cell cycle regulated human histone gene expression during differentiation. Cell Biophys. 1989 Dec; 15(3):201-23. PMID: 2480181.
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    531. van Wijnen AJ, Wright KL, Lian JB, Stein JL, Stein GS. Human H4 histone gene transcription requires the proliferation-specific nuclear factor HiNF-D. Auxiliary roles for HiNF-C (Sp1-like) and HiNF-A (high mobility group-like). J Biol Chem. 1989 Sep 5; 264(25):15034-42. PMID: 2768251.
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    532. Hauschka PV, Lian JB, Cole DE, Gundberg CM. Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiol Rev. 1989 Jul; 69(3):990-1047. PMID: 2664828.
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    533. Shalhoub V, Gerstenfeld LC, Collart D, Lian JB, Stein GS. Downregulation of cell growth and cell cycle regulated genes during chick osteoblast differentiation with the reciprocal expression of histone gene variants. Biochemistry. 1989 Jun 27; 28(13):5318-22. PMID: 2476172.
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    534. Puchacz E, Lian JB, Stein GS, Wozney J, Huebner K, Croce C. Chromosomal localization of the human osteocalcin gene. Endocrinology. 1989 May; 124(5):2648-50. PMID: 2785029.
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    535. Crigler JF, Glimcher MJ, Brown EM, Lian JB. In memory of Constantine Spiro Anast. Bone Miner. 1989 Mar; 5(3):iii-vii. PMID: 2655772.
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    536. Stein G, Lian J, Stein J, Briggs R, Shalhoub V, Wright K, Pauli U, van Wijnen A. Altered binding of human histone gene transcription factors during the shutdown of proliferation and onset of differentiation in HL-60 cells. Proc Natl Acad Sci U S A. 1989 Mar; 86(6):1865-9. PMID: 2928309.
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    537. Lian J, Stewart C, Puchacz E, Mackowiak S, Shalhoub V, Collart D, Zambetti G, Stein G. Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression. Proc Natl Acad Sci U S A. 1989 Feb; 86(4):1143-7. PMID: 2784002.
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    538. Marks SC, Mackowiak S, Shaloub V, Lian JB, Stein GS. Proliferation and differentiation of osteoblasts in osteopetrotic rats: modification in expression of genes encoding cell growth and extracellular matrix proteins. Connect Tissue Res. 1989; 21(1-4):107-13; discussion 114-6. PMID: 2605935.
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    539. Stein GS, Lian JB, Gerstenfeld LG, Shalhoub V, Aronow M, Owen T, Markose E. The onset and progression of osteoblast differentiation is functionally related to cellular proliferation. Connect Tissue Res. 1989; 20(1-4):3-13. PMID: 2612161.
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    540. Glowacki J, Rey C, Cox K, Lian J. Effects of bone matrix components on osteoclast differentiation. Connect Tissue Res. 1989; 20(1-4):121-9. PMID: 2692953.
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    541. Gerstenfeld LC, Lian JB, Gotoh Y, Lee DD, Landis WJ, McKee MD, Nanci A, Glimcher MJ. Use of cultured embryonic chicken osteoblasts as a model of cellular differentiation and bone mineralization. Connect Tissue Res. 1989; 21(1-4):215-23; discussion 224-5. PMID: 2605946.
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    542. Lian JB, Stein GS, Stewart C, Puchacz E, Mackowiak S, Aronow M, Von Deck M, Shalhoub V. Osteocalcin: characterization and regulated expression of the rat gene. Connect Tissue Res. 1989; 21(1-4):61-8; discussion 69. PMID: 2605954.
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    543. Rey C, Lian J, Grynpas M, Shapiro F, Zylberberg L, Glimcher MJ. Non-apatitic environments in bone mineral: FT-IR detection, biological properties and changes in several disease states. Connect Tissue Res. 1989; 21(1-4):267-73. PMID: 2605951.
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    544. Collar DG, Wright KL, van Wijnen AJ, Ramsey AL, Lian J, Stein JL, Stein GS. The human H1 histone gene FNC16 is functionally expressed in proliferating HeLa S3 cells and is down-regulated during terminal differentiation in HL60 cells. J Biol Chem. 1988 Nov 5; 263(31):15860-3. PMID: 3182772.
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    545. Canalis E, Lian JB. Effects of bone associated growth factors on DNA, collagen and osteocalcin synthesis in cultured fetal rat calvariae. Bone. 1988; 9(4):243-6. PMID: 3262362.
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    546. Lian JB, Gundberg CM. Osteocalcin. Biochemical considerations and clinical applications. Clin Orthop Relat Res. 1988 Jan; (226):267-91. PMID: 3275514.
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    547. Pauli RM, Lian JB, Mosher DF, Suttie JW. Association of congenital deficiency of multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embryopathy: clues to the mechanism of teratogenicity of coumarin derivatives. Am J Hum Genet. 1987 Oct; 41(4):566-83. PMID: 3499071.
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    548. Glowacki J, Lian JB. Impaired recruitment and differentiation of osteoclast progenitors by osteocalcin-deplete bone implants. Cell Differ. 1987 Sep; 21(4):247-54. PMID: 3304665.
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    549. Gerstenfeld LC, Chipman SD, Glowacki J, Lian JB. Expression of differentiated function by mineralizing cultures of chicken osteoblasts. Dev Biol. 1987 Jul; 122(1):49-60. PMID: 3496252.
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    550. Lian JB, Carnes DL, Glimcher MJ. Bone and serum concentrations of osteocalcin as a function of 1,25-dihydroxyvitamin D3 circulating levels in bone disorders in rats. Endocrinology. 1987 May; 120(5):2123-30. PMID: 3494594.
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    551. Lian JB, Dunn K, Key LL. In vitro degradation of bone particles by human monocytes is decreased with the depletion of the vitamin K-dependent bone protein from the matrix. Endocrinology. 1986 Apr; 118(4):1636-42. PMID: 3512259.
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    552. Mackowiak S, Gerstenfeld L, Hauschka PV, Lian JB. Cell-free translation of the vitamin K-dependent bone protein osteocalcin. Biochem Biophys Res Commun. 1985 Oct 15; 132(1):240-4. PMID: 3877507.
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    553. Lian JB, Coutts M, Canalis E. Studies of hormonal regulation of osteocalcin synthesis in cultured fetal rat calvariae. J Biol Chem. 1985 Jul 25; 260(15):8706-10. PMID: 3894347.
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    554. Canalis E, Lian JB. 1,25-Dihydroxyvitamin D3 effects on collagen and DNA synthesis in periosteum and periosteum-free calvaria. Bone. 1985; 6(6):457-60. PMID: 3841646.
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    555. Lian JB, Gundberg CM, Hauschka PV, Gallop PM. gamma-Carboxyglutamic acid. Methods Enzymol. 1985; 113:133-46. PMID: 3910998.
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    556. Slovik DM, Gundberg CM, Neer RM, Lian JB. Clinical evaluation of bone turnover by serum osteocalcin measurements in a hospital setting. J Clin Endocrinol Metab. 1984 Aug; 59(2):228-30. PMID: 6610686.
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    557. Lian JB, Tassinari M, Glowacki J. Resorption of implanted bone prepared from normal and warfarin-treated rats. J Clin Invest. 1984 Apr; 73(4):1223-6. PMID: 6608532.
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    558. Gundberg CM, Hauschka PV, Lian JB, Gallop PM. Osteocalcin: isolation, characterization, and detection. Methods Enzymol. 1984; 107:516-44. PMID: 6094965.
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    559. Gundberg CM, Lian JB, Gallop PM, Steinberg JJ. Urinary gamma-carboxyglutamic acid and serum osteocalcin as bone markers: studies in osteoporosis and Paget's disease. J Clin Endocrinol Metab. 1983 Dec; 57(6):1221-5. PMID: 6605357.
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    560. Lian JB, Boivin G, Patterson-Allen P, Grynpas M, Walzer C. Calcergy and calciphylaxis: timed appearance of gamma-carboxyglutamic acid and osteocalcin in mineral deposits. Calcif Tissue Int. 1983 Jul; 35(4-5):555-61. PMID: 6311379.
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    561. Gundberg CM, Cole DE, Lian JB, Reade TM, Gallop PM. Serum osteocalcin in the treatment of inherited rickets with 1,25-dihydroxyvitamin D3. J Clin Endocrinol Metab. 1983 May; 56(5):1063-7. PMID: 6601111.
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    562. Gundberg CM, Lian JB, Gallop PM. Measurements of gamma-carboxyglutamate and circulating osteocalcin in normal children and adults. Clin Chim Acta. 1983 Feb 28; 128(1):1-8. PMID: 6601547.
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    563. Lian JB, Cohen-Solal L, Kossiva D, Glimcher MJ. Changes in phosphoproteins of chicken bone matrix in vitamin D-deficient rickets. FEBS Lett. 1982 Nov 22; 149(1):123-5. PMID: 7152029.
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    564. Lian JB, Pachman LM, Gundberg CM, Partridge RE, Maryjowski MC. Gamma-carboxyglutamate excretion and calcinosis in juvenile dermatomyositis. Arthritis Rheum. 1982 Sep; 25(9):1094-1100. PMID: 6982044.
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    565. Lian JB, Glimcher MJ, Roufosse AH, Hauschka PV, Gallop PM, Cohen-Solal L, Reit B. Alterations of the gamma-carboxyglutamic acid and osteocalcin concentrations in vitamin D-deficient chick bone. J Biol Chem. 1982 May 10; 257(9):4999-5003. PMID: 6802844.
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    566. Lian JB, Roufosse AH, Reit B, Glimcher MJ. Concentrations of osteocalcin and phosphoprotein as a function of mineral content and age in cortical bone. Calcif Tissue Int. 1982; 34 Suppl 2:S82-7. PMID: 6816454.
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    567. Lian JB, Levy RJ, Bernhard W, Szycher M. LVAD mineralization and gamma-carboxyglutamic acid containing proteins in normal and pathologically mineralized tissues. Trans Am Soc Artif Intern Organs. 1981; 27:683-9. PMID: 6977229.
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    568. Gallop PM, Lian JB, Hauschka PV. Carboxylated calcium-binding proteins and vitamin K. N Engl J Med. 1980 Jun 26; 302(26):1460-6. PMID: 6990261.
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    569. Levy RJ, Zenker JA, Lian JB. Vitamin K-dependent calcium binding proteins in aortic valve calcification. J Clin Invest. 1980 Feb; 65(2):563-6. PMID: 7356695.
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    570. Gundberg CM, Lian JB, Gallop PM. gamma-Carboxyglutamate analysis by selective anion exchange elution and fluorescent detection. Anal Biochem. 1979 Sep 15; 98(1):219-25. PMID: 543555.
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    571. Cohen-Solal L, Lian JB, Kossiva D, Glimcher MJ. Identification of organic phosphorus covalently bound to collagen and non-collagenous proteins of chicken-bone matrix. The presence of O-phosphoserine and O-phosphothreonine in non-collagenous proteins, and their absence from phosporylated collagen. Biochem J. 1979 Jan 1; 177(1):81-98. PMID: 106848.
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    572. Lian JB, Friedman PA. The vitamin K-dependent synthesis of gamma-carboxyglutamic acid by bone microsomes. J Biol Chem. 1978 Oct 10; 253(19):6623-6. PMID: 567642.
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    573. Lian JB, Hauschka PV, Gallop PM. Properties and biosynthesis of a vitamin K-dependent calcium binding protein in bone. Fed Proc. 1978 Oct; 37(12):2615-20. PMID: 700171.
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    574. Cohen-Solal L, Lian JB, Kossiva D, Glimcher MJ. The identification of O-phosphothreonine in the soluble non-collagenous phosphoproteins of bone matrix. FEBS Lett. 1978 May 1; 89(1):107-10. PMID: 658389.
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    575. Lian JB, Prien EL, Glimcher MJ, Gallop PM. The presence of protein-bound gamma-carboxyglutamic acid in calcium-containing renal calculi. J Clin Invest. 1977 Jun; 59(6):1151-7. PMID: 864007.
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    576. Lian JB, Skinner M, Benson MD, Cohen AS. Fractionation of primary amyloid fibrils. Characterization and chemical interaction of the subunits. Biochim Biophys Acta. 1977 Mar 28; 491(1):167-76. PMID: 402949.
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    577. Lian JB, Skinner M, Glimcher MJ, Gallop P. The presence of gamma-carboxyglutamic acid in the proteins associated with ectopic calcification. Biochem Biophys Res Commun. 1976 Nov 22; 73(2):349-55. PMID: 999715.
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    578. Lian JB, Benson MD, Skinner M, Cohen AS. A 25,000 molecular weight protein constituent of human amyloid fibrils related to amyloid protein AA. Arch Biochem Biophys. 1975 Nov; 171(1):197-205. PMID: 811172.
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    579. Hauschka PV, Lian JB, Gallop PM. Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue. Proc Natl Acad Sci U S A. 1975 Oct; 72(10):3925-9. PMID: 1060074.
      View in: PubMed
    580. Benson MD, Skinner M, Lian J, Cohen AS. "A" protein of amyloidosis. Isolation of a cross-reacting component from serum by affinity chromatography. Arthritis Rheum. 1975 Jul-Aug; 18(4):315-22. PMID: 50844.
      View in: PubMed
    581. Lian JB, Morris S, Faris B, Albright J, Franzblau C. The effects of acetic acid and pepsin on the crosslinkages and ultrastructure of corneal collagen. Biochim Biophys Acta. 1973 Nov 11; 328(1):193-204. PMID: 4586831.
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