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Barbara A Osborne PhD

TitleMCB Director
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
Address427F Integrated Sciences Building
Amherst, MA 01003
Phone413 545-4882
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lessard CB, Rodriguez E, Ladd TB, Minter LM, Osborne BA, Miele L, Golde TE, Ran Y. Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells. J Biol Chem. 2019 Jun 05. PMID: 31167792.
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    2. Geiger S, Ozay EI, Geumann U, Hereth MK, Magnusson T, Shanthalingam S, Hirsch D, Kälin S, Günther C, Osborne BA, Tew GN, Hermann FG, Minter LM. Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD. Mol Ther. 2019 May 16. PMID: 31138510.
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    3. Sorrentino C, Hossain F, Rodriguez PC, Sierra RA, Pannuti A, Hatfield S, Osborne BA, Minter LM, Miele L, Morello S. Corrigendum: Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells. Front Immunol. 2019; 10:935. PMID: 31130947.
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    4. Sorrentino C, Hossain F, Rodriguez PC, Sierra RA, Pannuti A, Osborne BA, Minter LM, Miele L, Morello S. Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells. Front Immunol. 2019; 10:162. PMID: 30792717.
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    5. Ozay EI, Vijayaraghavan J, Gonzalez-Perez G, Shanthalingam S, Sherman HL, Garrigan DT, Chandiran K, Torres JA, Osborne BA, Tew GN, Slukvin II, Macdonald RA, Kelly K, Minter LM. Cymerus™ iPSC-MSCs significantly prolong survival in a pre-clinical, humanized mouse model of Graft-vs-host disease. Stem Cell Res. 2019 Feb 01; 35:101401. PMID: 30738321.
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    6. Munkhbat O, Canakci M, Zheng S, Hu W, Osborne B, Bogdanov AA, Thayumanavan S. 19F MRI Imaging of Polymer Nanogels Aided by Improved Segmental Mobility of Embedded Fluorine Moieties. Biomacromolecules. 2018 Dec 18. PMID: 30563327.
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    7. Hossain F, Sorrentino C, Ucar DA, Peng Y, Matossian M, Wyczechowska D, Crabtree J, Zabaleta J, Morello S, Del Valle L, Burow M, Collins-Burow B, Pannuti A, Minter LM, Golde TE, Osborne BA, Miele L. Notch Signaling Regulates Mitochondrial Metabolism and NF-?B Activity in Triple-Negative Breast Cancer Cells via IKKa-Dependent Non-canonical Pathways. Front Oncol. 2018; 8:575. PMID: 30564555.
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    8. Wongchana W, Kongkavitoon P, Tangtanatakul P, Sittplangkoon C, Butta P, Chawalitpong S, Pattarakankul T, Osborne BA, Palaga T. Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes. PLoS One. 2018; 13(6):e0198609. PMID: 29889863.
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    9. Hossain F, Majumder S, Ucar DA, Rodriguez PC, Golde TE, Minter LM, Osborne BA, Miele L. Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses. Front Immunol. 2018; 9:1288. PMID: 29915603.
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    10. Chandiran K, Lawlor R, Pannuti A, Perez GG, Srinivasan J, Golde TE, Miele L, Osborne BA, Minter LM. Notch1 primes CD4 T cells for T helper type I differentiation through its early effects on miR-29. Mol Immunol. 2018 Jul; 99:191-198. PMID: 29807327.
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    11. Vijayaraghavan J, Osborne BA. Notch and T Cell Function - A Complex Tale. Adv Exp Med Biol. 2018; 1066:339-354. PMID: 30030835.
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    12. Sierra RA, Trillo-Tinoco J, Mohamed E, Yu L, Achyut BR, Arbab A, Bradford JW, Osborne BA, Miele L, Rodriguez PC. Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance. Cancer Res. 2017 10 15; 77(20):5628-5638. PMID: 28904063.
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    13. Ran Y, Hossain F, Pannuti A, Lessard CB, Ladd GZ, Jung JI, Minter LM, Osborne BA, Miele L, Golde TE. ?-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct. EMBO Mol Med. 2017 May 24. PMID: 28539479.
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    14. Karau MJ, Tilahun ME, Krogman A, Osborne BA, Goldsby RA, David CS, Mandrekar JN, Patel R, Rajagopalan G. Passive therapy with humanized anti-staphylococcal enterotoxin B antibodies attenuates systemic inflammatory response and protects from lethal pneumonia caused by staphylococcal enterotoxin B-producing Staphylococcus aureus. Virulence. 2016 Dec 07; 1-12. PMID: 27925510.
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    15. Ozay EI, Gonzalez-Perez G, Torres JA, Vijayaraghavan J, Lawlor R, Sherman HL, Garrigan DT, Burnside AS, Osborne BA, Tew GN, Minter LM. Intracellular Delivery of Anti-pPKC? (Thr538) via Protein Transduction Domain Mimics for Immunomodulation. Mol Ther. 2016 Dec; 24(12):2118-2130. PMID: 27633441.
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    16. Wang Y, Yu S, Huang D, Cui M, Hu H, Zhang L, Wang W, Parameswaran N, Jackson M, Osborne B, Bedogni B, Li C, Sy MS, Xin W, Zhou L. Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1. Am J Pathol. 2016 Nov; 186(11):2945-2956. PMID: 27639164.
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    17. Moyano DF, Liu Y, Ayaz F, Hou S, Puangploy P, Duncan B, Osborne BA, Rotello VM. Immunomodulatory effects of coated gold nanoparticles in LPS-stimulated in vitro and in vivo murine model systems. Chem. 2016; 1(2):320-327. PMID: 28255579.
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    18. Montgomery MK, Fiveash CE, Braude JP, Osborne B, Brown SH, Mitchell TW, Turner N. Disparate metabolic response to fructose feeding between different mouse strains. Sci Rep. 2015 Dec 22; 5:18474. PMID: 26690387; PMCID: PMC4686880.
    19. Yun J, Espinoza I, Pannuti A, Romero D, Martinez L, Caskey M, Stanculescu A, Bocchetta M, Rizzo P, Band V, Band H, Kim HM, Park SK, Kang KW, Avantaggiati ML, Gomez CR, Golde T, Osborne B, Miele L. p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1. J Cell Physiol. 2015 Dec; 230(12):3115-27. PMID: 26033683.
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    20. Wongchana W, Lawlor RG, Osborne BA, Palaga T. Impact of Notch1 Deletion in Macrophages on Proinflammatory Cytokine Production and the Outcome of Experimental Autoimmune Encephalomyelitis. J Immunol. 2015 Dec 1; 195(11):5337-46. PMID: 26503951.
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    21. Prasad P, Molla MR, Cui W, Canakci M, Osborne B, Mager J, Thayumanavan S. Polyamide Nanogels from Generally Recognized as Safe Components and Their Toxicity in Mouse Preimplantation Embryos. Biomacromolecules. 2015 Nov 9; 16(11):3491-8. PMID: 26367020.
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    22. Gordon MR, Canakci M, Li L, Zhuang J, Osborne B, Thayumanavan S. Field Guide to Challenges and Opportunities in Antibody-Drug Conjugates for Chemists. Bioconjug Chem. 2015 Nov 18; 26(11):2198-215. PMID: 26308881.
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    23. Ayaz F, Osborne BA. Non-canonical notch signaling in cancer and immunity. Front Oncol. 2014; 4:345. PMID: 25538890.
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    24. Navasa N, Martín I, Iglesias-Pedraz JM, Beraza N, Atondo E, Izadi H, Ayaz F, Fernández-Álvarez S, Hatle K, Som A, Dienz O, Osborne BA, Martínez-Chantar ML, Rincón M, Anguita J. Regulation of oxidative stress by methylation-controlled J protein controls macrophage responses to inflammatory insults. J Infect Dis. 2015 Jan 1; 211(1):135-45. PMID: 25028693.
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    25. Shin HM, Tilahun ME, Cho OH, Chandiran K, Kuksin CA, Keerthivasan S, Fauq AH, Golde TE, Miele L, Thome M, Osborne BA, Minter LM. NOTCH1 Can Initiate NF-?B Activation via Cytosolic Interactions with Components of the T Cell Signalosome. Front Immunol. 2014; 5:249. PMID: 24904593.
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    26. Sangphech N, Osborne BA, Palaga T. Notch signaling regulates the phosphorylation of Akt and survival of lipopolysaccharide-activated macrophages via regulator of G protein signaling 19 (RGS19). Immunobiology. 2014 Sep; 219(9):653-60. PMID: 24775271.
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    27. Sgolastra F, Minter LM, Osborne BA, Tew GN. Importance of sequence specific hydrophobicity in synthetic protein transduction domain mimics. Biomacromolecules. 2014 Mar 10; 15(3):812-20. PMID: 24506414.
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    28. Dongre A, Surampudi L, Lawlor RG, Fauq AH, Miele L, Golde TE, Minter LM, Osborne BA. Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells. Front Immunol. 2014; 5:54. PMID: 24611064.
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    29. Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L. ?-Secretase inhibitors and modulators. Biochim Biophys Acta. 2013 Dec; 1828(12):2898-907. PMID: 23791707.
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    30. Tezgel AÖ, Gonzalez-Perez G, Telfer JC, Osborne BA, Minter LM, Tew GN. Novel protein transduction domain mimics as nonviral delivery vectors for siRNA targeting NOTCH1 in primary human T cells. Mol Ther. 2013 Jan; 21(1):201-9. PMID: 23070119.
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    31. Das P, Verbeeck C, Minter L, Chakrabarty P, Felsenstein K, Kukar T, Maharvi G, Fauq A, Osborne BA, Golde TE. Transient pharmacologic lowering of Aß production prior to deposition results in sustained reduction of amyloid plaque pathology. Mol Neurodegener. 2012 Aug 14; 7:39. PMID: 22892055.
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    32. Minter LM, Osborne BA. Notch and the survival of regulatory T cells: location is everything! Sci Signal. 2012 Jul 24; 5(234):pe31. PMID: 22827995.
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    33. Gu JW, Rizzo P, Pannuti A, Golde T, Osborne B, Miele L. Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy. Vasc Cell. 2012; 4:7. PMID: 22487493.
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    34. Minter LM, Osborne BA. Canonical and non-canonical Notch signaling in CD4? T cells. Curr Top Microbiol Immunol. 2012; 360:99-114. PMID: 22695917.
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    35. Tilahun ME, Kwan A, Natarajan K, Quinn M, Tilahun AY, Xie C, Margulies DH, Osborne BA, Goldsby RA, Rajagopalan G. Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB. PLoS One. 2011; 6(11):e27203. PMID: 22102880.
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    36. Keerthivasan S, Suleiman R, Lawlor R, Roderick J, Bates T, Minter L, Anguita J, Juncadella I, Nickoloff BJ, Le Poole IC, Miele L, Osborne BA. Notch signaling regulates mouse and human Th17 differentiation. J Immunol. 2011 Jul 15; 187(2):692-701. PMID: 21685328.
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    37. Osborne BA. Notch, a T-ALL order. Blood. 2011 Mar 10; 117(10):2749-50. PMID: 21393498.
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    38. Juncadella IJ, Bates TC, Suleiman R, Monteagudo-Mera A, Olson CM, Navasa N, Olivera ER, Osborne BA, Anguita J. The tick saliva immunosuppressor, Salp15, contributes to Th17-induced pathology during Experimental Autoimmune Encephalomyelitis. Biochem Biophys Res Commun. 2010 Nov 5; 402(1):105-9. PMID: 20920474.
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    39. Pannuti A, Foreman K, Rizzo P, Osipo C, Golde T, Osborne B, Miele L. Targeting Notch to target cancer stem cells. Clin Cancer Res. 2010 Jun 15; 16(12):3141-52. PMID: 20530696.
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    40. Tilahun ME, Rajagopalan G, Shah-Mahoney N, Lawlor RG, Tilahun AY, Xie C, Natarajan K, Margulies DH, Ratner DI, Osborne BA, Goldsby RA. Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies. Infect Immun. 2010 Jun; 78(6):2801-11. PMID: 20308304.
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    41. Yan H, Blackburn AC, McLary SC, Tao L, Roberts AL, Xavier EA, Dickinson ES, Seo JH, Arenas RB, Otis CN, Cao QJ, Lawlor RG, Osborne BA, Kittrell FS, Medina D, Jerry DJ. Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice. Am J Pathol. 2010 Mar; 176(3):1421-32. PMID: 20110418.
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    42. Hao L, Rizzo P, Osipo C, Pannuti A, Wyatt D, Cheung LW, Sonenshein G, Osborne BA, Miele L. Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Oncogene. 2010 Jan 14; 29(2):201-13. PMID: 19838210.
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    43. Wang A, Rud J, Olson CM, Anguita J, Osborne BA. Phosphorylation of Nur77 by the MEK-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T cells. J Immunol. 2009 Sep 1; 183(5):3268-77. PMID: 19675165.
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    44. Cho OH, Shin HM, Miele L, Golde TE, Fauq A, Minter LM, Osborne BA. Notch regulates cytolytic effector function in CD8+ T cells. J Immunol. 2009 Mar 15; 182(6):3380-9. PMID: 19265115.
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    45. Osborne BA. B-CLL kicks it up a Notch. Blood. 2009 Jan 22; 113(4):765-6. PMID: 19164502.
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    46. Rizzo P, Osipo C, Pannuti A, Golde T, Osborne B, Miele L. Targeting Notch signaling cross-talk with estrogen receptor and ErbB-2 in breast cancer. Adv Enzyme Regul. 2009; 49(1):134-41. PMID: 19344631.
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    47. Joshi I, Minter LM, Telfer J, Demarest RM, Capobianco AJ, Aster JC, Sicinski P, Fauq A, Golde TE, Osborne BA. Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood. 2009 Feb 19; 113(8):1689-98. PMID: 19001083.
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    48. Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, Miele L. Rational targeting of Notch signaling in cancer. Oncogene. 2008 Sep 1; 27(38):5124-31. PMID: 18758481.
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    49. Song LL, Peng Y, Yun J, Rizzo P, Chaturvedi V, Weijzen S, Kast WM, Stone PJ, Santos L, Loredo A, Lendahl U, Sonenshein G, Osborne B, Qin JZ, Pannuti A, Nickoloff BJ, Miele L. Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells. Oncogene. 2008 Oct 2; 27(44):5833-44. PMID: 18560356.
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    50. Samon JB, Champhekar A, Minter LM, Telfer JC, Miele L, Fauq A, Das P, Golde TE, Osborne BA. Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood. 2008 Sep 1; 112(5):1813-21. PMID: 18550850.
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    51. Palaga T, Buranaruk C, Rengpipat S, Fauq AH, Golde TE, Kaufmann SH, Osborne BA. Notch signaling is activated by TLR stimulation and regulates macrophage functions. Eur J Immunol. 2008 Jan; 38(1):174-83. PMID: 18085664.
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    52. Osipo C, Golde TE, Osborne BA, Miele LA. Off the beaten pathway: the complex cross talk between Notch and NF-kappaB. Lab Invest. 2008 Jan; 88(1):11-7. PMID: 18059366.
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    53. Izadi H, Motameni AT, Bates TC, Olivera ER, Villar-Suarez V, Joshi I, Garg R, Osborne BA, Davis RJ, Rincón M, Anguita J. c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophages. Infect Immun. 2007 Oct; 75(10):5027-34. PMID: 17664270.
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    54. Morgan GA, Guo Q, Chan SL, Gary DS, Osborne BA, Mattson MP. Defects of immune regulation in the presenilin-1 mutant knockin mouse. Neuromolecular Med. 2007; 9(1):35-45. PMID: 17114823.
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    55. Osborne BA, Minter LM. Notch signalling during peripheral T-cell activation and differentiation. Nat Rev Immunol. 2007 Jan; 7(1):64-75. PMID: 17170755.
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    56. Miele L, Golde T, Osborne B. Notch signaling in cancer. Curr Mol Med. 2006 Dec; 6(8):905-18. PMID: 17168741.
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    57. Shin HM, Minter LM, Cho OH, Gottipati S, Fauq AH, Golde TE, Sonenshein GE, Osborne BA. Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J. 2006 Jan 11; 25(1):129-38. PMID: 16319921.
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    58. Granowitz EV, Tonomura N, Benson RM, Katz DM, Band V, Makari-Judson GP, Osborne BA. Hyperbaric oxygen inhibits benign and malignant human mammary epithelial cell proliferation. Anticancer Res. 2005 Nov-Dec; 25(6B):3833-42. PMID: 16312043.
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    59. Minter LM, Turley DM, Das P, Shin HM, Joshi I, Lawlor RG, Cho OH, Palaga T, Gottipati S, Telfer JC, Kostura L, Fauq AH, Simpson K, Such KA, Miele L, Golde TE, Miller SD, Osborne BA. Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol. 2005 Jul; 6(7):680-8. PMID: 15991363.
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    60. Osborne BA, Kee BL. Lymphoid development: it's not 'all Greek to us' any more. Nat Immunol. 2005 Feb; 6(2):119-23. PMID: 15662436.
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    61. Laws AM, Osborne BA. p53 regulates thymic Notch1 activation. Eur J Immunol. 2004 Mar; 34(3):726-34. PMID: 14991602.
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    62. Benson RM, Minter LM, Osborne BA, Granowitz EV. Hyperbaric oxygen inhibits stimulus-induced proinflammatory cytokine synthesis by human blood-derived monocyte-macrophages. Clin Exp Immunol. 2003 Oct; 134(1):57-62. PMID: 12974755.
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    63. Nickoloff BJ, Osborne BA, Miele L. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents. Oncogene. 2003 Sep 29; 22(42):6598-608. PMID: 14528285.
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    64. Palaga T, Miele L, Golde TE, Osborne BA. TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. J Immunol. 2003 Sep 15; 171(6):3019-24. PMID: 12960327.
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    65. Cheng P, Nefedova Y, Miele L, Osborne BA, Gabrilovich D. Notch signaling is necessary but not sufficient for differentiation of dendritic cells. Blood. 2003 Dec 1; 102(12):3980-8. PMID: 12907456.
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    66. Minter LM, Osborne BA. Cell death in the thymus--it' s all a matter of contacts. Semin Immunol. 2003 Jun; 15(3):135-44. PMID: 14563112.
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    67. Tonomura N, McLaughlin K, Grimm L, Goldsby RA, Osborne BA. Glucocorticoid-induced apoptosis of thymocytes: requirement of proteasome-dependent mitochondrial activity. J Immunol. 2003 Mar 1; 170(5):2469-78. PMID: 12594272.
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    68. Ganguly BJ, Tonomura N, Benson RM, Osborne BA, Granowitz EV. Hyperbaric oxygen enhances apoptosis in hematopoietic cells. Apoptosis. 2002 Dec; 7(6):499-510. PMID: 12370492.
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    69. Lee JM, Lee KH, Weidner M, Osborne BA, Hayward SD. Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosis. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11878-83. PMID: 12195020.
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    70. Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer SM, Zlobin A, Osborne BA, Gottipati S, Aster JC, Hahn WC, Rudolf M, Siziopikou K, Kast WM, Miele L. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med. 2002 Sep; 8(9):979-86. PMID: 12185362.
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    71. Kuroiwa Y, Kasinathan P, Choi YJ, Naeem R, Tomizuka K, Sullivan EJ, Knott JG, Duteau A, Goldsby RA, Osborne BA, Ishida I, Robl JM. Cloned transchromosomic calves producing human immunoglobulin. Nat Biotechnol. 2002 Sep; 20(9):889-94. PMID: 12172556.
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    72. Palaga T, Osborne B. The 3D's of apoptosis: death, degradation and DIAPs. Nat Cell Biol. 2002 Jun; 4(6):E149-51. PMID: 12042828.
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    73. Collas P, Cline R, Landsverk HB, Hein WR, Goldsby RA, Osborne BA, Landsverk T. DNA-containing extracellular 50-nm particles in the ileal Peyer's patch of sheep. Eur J Cell Biol. 2002 Feb; 81(2):69-76. PMID: 11893084.
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    74. Cheng P, Zlobin A, Volgina V, Gottipati S, Osborne B, Simel EJ, Miele L, Gabrilovich DI. Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells. J Immunol. 2001 Oct 15; 167(8):4458-67. PMID: 11591772.
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    75. Jeong Y, Osborne BA, Goldsby RA. Early Vlambda diversification in sheep. Immunology. 2001 May; 103(1):26-34. PMID: 11380689.
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    76. Valavanis C, Hu Y, Yang Y, Osborne BA, Chouaib S, Greene L, Ashwell JD, Schwartz LM. Model cell lines for the study of apoptosis in vitro. Methods Cell Biol. 2001; 66:417-36. PMID: 11396014.
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    77. Osborne BA. Transcriptional control of T cell development. Curr Opin Immunol. 2000 Jun; 12(3):301-6. PMID: 10781405.
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    78. Lockshin RA, Osborne B, Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000 Jan; 7(1):2-7. PMID: 10713714.
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    79. Miele L, Osborne B. Arbiter of differentiation and death: Notch signaling meets apoptosis. J Cell Physiol. 1999 Dec; 181(3):393-409. PMID: 10528225.
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    80. Osborne B, Miele L. Notch and the immune system. Immunity. 1999 Dec; 11(6):653-63. PMID: 10626888.
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    81. Amsen D, Revilla Calvo C, Osborne BA, Kruisbeek AM. Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):622-7. PMID: 9892683.
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    82. Jehn BM, Bielke W, Pear WS, Osborne BA. Cutting edge: protective effects of notch-1 on TCR-induced apoptosis. J Immunol. 1999 Jan 15; 162(2):635-8. PMID: 9916679.
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    83. Grimm LM, Osborne BA. Apoptosis and the proteasome. Results Probl Cell Differ. 1999; 23:209-28. PMID: 9950035.
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    84. Morgan G, Smith S, Pak J, Marshak-Rothstein A, Fissore R, Osborne B. Characterization of a mutant T-cell hybridoma line with defects in the TCR-mediated apoptotic pathway. Cell Death Differ. 1999 Jan; 6(1):36-47. PMID: 10200546.
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    85. Lucier MR, Thompson RE, Waire J, Lin AW, Osborne BA, Goldsby RA. Multiple sites of V lambda diversification in cattle. J Immunol. 1998 Nov 15; 161(10):5438-44. PMID: 9820519.
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    86. Bostwick DG, Iczkowski KA, Amin MB, Discigil G, Osborne B. Malignant lymphoma involving the prostate: report of 62 cases. Cancer. 1998 Aug 15; 83(4):732-8. PMID: 9708938.
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    87. Jehn BM, Osborne BA. Gene regulation associated with apoptosis. Crit Rev Eukaryot Gene Expr. 1997; 7(1-2):179-93. PMID: 9034721.
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    88. Meyer A, Parng CL, Hansal SA, Osborne BA, Goldsby RA. Immunoglobulin gene diversification in cattle. Int Rev Immunol. 1997; 15(3-4):165-83. PMID: 9222818.
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    89. Parng CL, Hansal S, Goldsby RA, Osborne BA. Gene conversion contributes to Ig light chain diversity in cattle. J Immunol. 1996 Dec 15; 157(12):5478-86. PMID: 8955197.
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    90. Osborne BA. Cell death in vertebrates: lessons from the worm. Trends Genet. 1996 Dec; 12(12):489-91. PMID: 9257523.
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    91. Grimm LM, Goldberg AL, Poirier GG, Schwartz LM, Osborne BA. Proteasomes play an essential role in thymocyte apoptosis. EMBO J. 1996 Aug 1; 15(15):3835-44. PMID: 8670888.
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    92. McLaughlin KA, Osborne BA, Goldsby RA. The role of oxygen in thymocyte apoptosis. Eur J Immunol. 1996 May; 26(5):1170-4. PMID: 8647183.
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    93. Osborne BA. Apoptosis and the maintenance of homoeostasis in the immune system. Curr Opin Immunol. 1996 Apr; 8(2):245-54. PMID: 8725948.
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    94. Osborne BA, Smith SW, McLaughlin KA, Grimm L, Kallinch T, Liu Z, Schwartz LM. Genes that regulate apoptosis in the mouse thymus. J Cell Biochem. 1996 Jan; 60(1):18-22. PMID: 8825411.
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    95. Osborne BA, Smith SW, McLaughlin KA, Grimm L, Morgan G, Goldsby RA. Genetic regulation of apoptosis in the mouse thymus. Adv Exp Med Biol. 1996; 406:199-207. PMID: 8910686.
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    96. Parng CL, Hansal S, Goldsby RA, Osborne BA. Diversification of bovine lambda-light chain genes. Ann N Y Acad Sci. 1995 Sep 29; 764:155-7. PMID: 7486515.
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    97. Slavin MA, Osborne B, Adams R, Levenstein MJ, Schoch HG, Feldman AR, Meyers JD, Bowden RA. Efficacy and safety of fluconazole prophylaxis for fungal infections after marrow transplantation--a prospective, randomized, double-blind study. J Infect Dis. 1995 Jun; 171(6):1545-52. PMID: 7769290.
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    98. Osborne BA, Schwartz LM. Cell death suffers a TKO. Bioessays. 1995 Jun; 17(6):557-9. PMID: 7575499.
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    99. Osborne BA. Induction of genes during apoptosis: examples from the immune system. Semin Cancer Biol. 1995 Feb; 6(1):27-33. PMID: 7548838.
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    100. Osborne BA, Smith SW, Liu ZG, McLaughlin KA, Schwartz LM. Transient transfection assays to examine the requirement of putative cell death genes. Methods Cell Biol. 1995; 46:99-106. PMID: 7541887.
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    101. Smith SW, McLaughlin KA, Osborne BA. Molecular events in thymocyte apoptosis. Curr Top Microbiol Immunol. 1995; 200:147-62. PMID: 7634829.
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    102. Osborne BA, Smith SW, Liu ZG, McLaughlin KA, Grimm L, Schwartz LM. Identification of genes induced during apoptosis in T lymphocytes. Immunol Rev. 1994 Dec; 142:301-20. PMID: 7698798.
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    103. Osborne BA, Schwartz LM. Essential genes that regulate apoptosis. Trends Cell Biol. 1994 Nov; 4(11):394-9. PMID: 14731815.
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    104. Schwartz LM, Osborne BA. Ced-3/ICE: evolutionarily conserved regulation of cell death. Bioessays. 1994 Jun; 16(6):387-9. PMID: 8080427.
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    105. Ravichandran KS, Osborne BA, Goldsby RA. Quantitative analysis of the B cell repertoire by limiting dilution analysis and fluorescent in situ hybridization. Cell Immunol. 1994 Apr 1; 154(1):309-27. PMID: 8131205.
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    106. Punt JA, Osborne BA, Takahama Y, Sharrow SO, Singer A. Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J Exp Med. 1994 Feb 1; 179(2):709-13. PMID: 8294878.
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    107. Liu ZG, Smith SW, McLaughlin KA, Schwartz LM, Osborne BA. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature. 1994 Jan 20; 367(6460):281-4. PMID: 8121494.
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    108. Schwartz LM, Osborne BA. Programmed cell death, apoptosis and killer genes. Immunol Today. 1993 Dec; 14(12):582-90. PMID: 8305131.
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    109. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 1993 Apr 29; 362(6423):847-9. PMID: 8479522.
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    110. Schwartz LM, Smith SW, Jones ME, Osborne BA. Do all programmed cell deaths occur via apoptosis? Proc Natl Acad Sci U S A. 1993 Feb 1; 90(3):980-4. PMID: 8430112.
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    111. Ravichandran KS, Semproni AR, Goldsby RA, Osborne BA. Immunoglobulin VH usage analysis by fluorescent in situ hybridization and flow cytometry. J Immunol Methods. 1992 Aug 30; 153(1-2):249-59. PMID: 1517596.
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    112. Harrington RD, Hooton TM, Hackman RC, Storch GA, Osborne B, Gleaves CA, Benson A, Meyers JD. An outbreak of respiratory syncytial virus in a bone marrow transplant center. J Infect Dis. 1992 Jun; 165(6):987-93. PMID: 1583345.
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    113. Ferguson SE, Cancro MP, Osborne BA. Analysis of a novel VHS107 haplotype in CLA-2 and WSA mice. Evidence for gene conversion among IgVH genes in outbred populations. J Exp Med. 1989 Dec 1; 170(6):1811-23. PMID: 2584925.
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    114. Ferguson SE, Rudikoff S, Osborne BA. Interaction and sequence diversity among T15 VH genes in CBA/J mice. J Exp Med. 1988 Oct 1; 168(4):1339-49. PMID: 3139820.
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    115. Osborne BA, Golde TE, Schwartz RL, Rudikoff S. Evolution of the IgA heavy chain gene in the genus Mus. Genetics. 1988 Aug; 119(4):925-31. PMID: 2842228.
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    116. Osborne BA, Golde TE, Schwartz RL, Rudikoff S. Evolution of the mouse IgA gene: nucleotide sequence comparison of IgA in BALB/c and Mus pahari. Curr Top Microbiol Immunol. 1986; 127:141-8. PMID: 3731840.
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    117. Osborne BA, Lunney JK, Pennington L, Sachs DH, Rudikoff S. Two-dimensional gel analysis of swine histocompatibility antigens. J Immunol. 1983 Dec; 131(6):2939-44. PMID: 6580344.
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    118. Osborne BA, Rudikoff S. Murine thymocyte and splenocyte Ia antigens are indistinguishable by two-dimensional gel electrophoresis. J Immunol. 1983 Sep; 131(3):1386-90. PMID: 6604097.
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    119. Lunney JK, Osborne BA, Sharrow SO, Devaux C, Pierres M, Sachs DH. Sharing of Ia antigens between species. IV. Interspecies cross-reactivity of monoclonal antibodies directed against polymorphic mouse Ia determinants. J Immunol. 1983 Jun; 130(6):2786-93. PMID: 6406596.
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    120. Roth JA, Grimm EA, Osborne BA, Putnam JB, Davidson DD, Ames RS. Suppressive immunoregulatory factors produced by tumors. Lymphokine Res. 1983; 2(2):67-73. PMID: 6332246.
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    121. Roth JA, Osborne BA, Ames RS. Immunoregulatory factors derived from human tumors. II. Partial purification and further immunobiochemical characterization of a human sarcoma-derived immunosuppressive factor expressing HLA-DR and immunoglobulin-related determinants. J Immunol. 1983 Jan; 130(1):303-8. PMID: 6183354.
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    122. Metzger JJ, Gilliland GL, Lunney JK, Osborne BA, Rudikoff S, Sachs DH. Transplantation in miniature swine. IX. Swine histocompatibility antigens: isolation and purification of papain-solubilized SLA antigens. J Immunol. 1981 Aug; 127(2):769-75. PMID: 7195920.
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    123. Engleman EG, Benike C, Osborne B, Goldsby R. Functional characteristics of human T-cell subpopulations distinguished by a monoclonal antibody. Proc Natl Acad Sci U S A. 1980 Mar; 77(3):1607-11. PMID: 6445560.
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    124. Suomalainen HA, Goldsby RA, Osborne BA, Schröder J. Mouse/human T-cell hybrids rosetting with sheep erythrocytes. Scand J Immunol. 1980; 11(2):163-8. PMID: 9537042.
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    125. Goldsby RA, Osborne BA, Suri D, Mandel A, Williams J, Gronowicz E, Herzenberg LA. Production of specific antibody without specific immunization. Curr Top Microbiol Immunol. 1978; 81:149-51. PMID: 308436.
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    126. Osborne BA, Goldsby RA, Herzenberg LA. Selective expression of loci in th I--J region on T cell hybrids. Curr Top Microbiol Immunol. 1978; 81:217-20. PMID: 80306.
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    127. Baroin A, Thomas DD, Osborne B, Devaux PF. Saturation transfer electron paramagnetic resonance on membrane-bound proteins. I-Rotational diffusion of rhodopsin in the visual receptor membrane. Biochem Biophys Res Commun. 1977 Sep 9; 78(1):442-7. PMID: 199170.
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    128. Goldsby RA, Osborne BA, Simpson E, Herzenberg LA. Hybrid cell lines with T-cell characteristics. Nature. 1977 Jun 23; 267(5613):707-8. PMID: 301614.
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    129. Herzenberg LA, Herzenberg LA, Black SJ, Loken MR, Okumura K, van der Loo W, Osborne BA, Hewgill D, Goding JW, Gutman G, Warner NL. Surface markers and functional relationships of cells involved in murine B-lymphocyte differentiation. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 1:33-45. PMID: 408094.
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    130. Glode LM, Scher I, Osborne B, Rosenstreich DL. Cellular mechanism of endotoxin unresponsiveness in C3H/HeJ mice. J Immunol. 1976 Feb; 116(2):454-61. PMID: 129492.
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    131. Kos KA, Osborne BA, Goldsby RA. Inhibition of group B arbovirus antigen production and replication in cells enucleated with cytochalasin B. J Virol. 1975 Apr; 15(4):913-7. PMID: 1090752.
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