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Evgeny I Rogaev PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentPsychiatry
AddressUMass Chan Medical School
303 Belmont Street
Worcester MA 01605
Phone508-856-8438
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentPsychiatry

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBioinformatics and Computational Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology


    Collapse Biography 
    Collapse education and training
    Lomonosov Moscow State University, Lomonosov, , Russian FederationMSBiology
    Russian Academy of Sciences, Moscow, , Russian FederationDSMedical Sciences
    Russian Academy of Sciences, Moscow, , Russian FederationPHDMedical Genetics

    Collapse Overview 
    Collapse overview

    Academic Background

    Education

    Moscow State University, Biological Department, School of Genetics

    Master D. 1983
    Ph.D. 1988
    Dr.Sci. 1996

    Work History

    Scientific Researcher, Leading Researcher
    National Mental Research Center
    Russian Academy of Medical Science
    1985-1990
    Visiting Scientist, Visiting Professor (U of Toronto) 1992-1995, 2001
    Head, Laboratory of Molecular Brain Genetics
    Research Center of Mental Health
    Russian Academy of Medical Sciences
    1990- present
    Professor of Psychiatry, BNRI, UMASS Medical School 2002- present

    Molecular genetic mechanisms of neuropsychiatric diseases and dementia
    Mapping and Positional cloning of genes for human pathologies

    Photo: Evgeny Rogaev, PhD, DrSciOur research is focused on the identification of genes and cellular proteins that play a critical role in normal and pathological aspects of human behavior. To identify such genes and proteins we first use the strategies of linkage, genetic association analysis and positional cloning to isolate the mutant or polymorphic genes underlying the human diseases. We then develop functional assays to express these genes in vitro and in vivo to study their normal and pathogenic functions.

    We are interested also in the study of evolutionary aspects of human populations, genome and specific genes in order to elucidate the phenomenon of some behavioral disorders prevalent in humankind.

    Alzheimer's disease, schizophrenia and depression are three of the most common mental disorders and our primary interest.

    Alzheimer's Disease

    The mutations in human presenilin 1 and presenilin 2 genes, which we and our colleagues described previously, are a major cause of familial early-onset Alzheimer's disease. The AD-mutations in the presenilins are supposed to enhance its proteolysis-associated activity, that in turn may result in elevated amyloid precursor protein cleavage and production of neurotoxic beta amyloid derivates. However, other "non-amyloid" mechanisms of pathogenic effects of presenilins have not yet been ruled out. The role of presenilins in most common "non-familial" AD cases, and cellular factors or chemical compounds which may modulate the activity of presenilins, are still unclear. Our studies search for factors that may regulate presenilin genes and interact with presenilin proteins. We search for population variations and modifications in promoters of presenilin 1 and presenilin 2 genes and measure the transcriptional activity of variable regulatory regions of presenilins. The potential exogenous and endogenous inhibitors or repressors of these elements are tested in neural human or rat cells. We also search for families of proteins that interact directly with presenilins or their targets (e.g., Amyloid Precursor Protein and Notch-receptors) and which may serve as modulators of presenilin mediated proteolysis. These studies will contribute to understanding of fundamental mechanisms of inter- and intra-cellular signaling and also provide potential targets for treatment of Alzheimer's disease neuro-degeneration.

    More than 50% of AD have no association with mutations in encoding regions of presenilins and other known AD -genes (ApoE,APP). Thus, there must be other AD genes yet to be discovered. In order to identify such genes, we combine the methods of genetic association and linkage analysis in families and population groups of late-onset AD patients and age-matched non-demented individuals. We test the single nucleotide polymorphisms (SNPs) in several selected chromosomal loci to define the narrow genomic region and ultimately identify novel genes associated with AD.

    Schizophrenia and Depression

    The molecular-genetic mechanisms and genes for schizophrenia or affective disorders remains to be elusive. We are collecting large samples of schizophrenia and affective disorders from ethnically defined populations. The identification of specific SNPs haplotypes and linkage disequilibrium analysis for a few candidate loci and genes are currently of our particular interest. A MassARRAY MALDI system will be used for fine mapping of these loci. Recently two novel candidate-genes for schizophrenia have been isolated from two chromosomal loci by testing of multiple polymorphic markers in two population samples. These primary data are to be replicated in the genetic study of other population samples. To elucidate the biological significance of the candidate-genes found by genetic approach, the study of effects of up- and down regulation of the candidate- genes on neuroplasticity and neurotransmition signaling will be undertaken.

    Other Diseases

    It is assumed that common diseases represent mainly polygenic or multifactorial diseases. The identification of the susceptible genes for such diseases is rather complicated. However, familial (Mendelian) transmission of diseases which may be clinically similar to common phenotypes is observed in rare families. We are interested in identifying and studying such families. Isolation of the disease genes in these rare families may help to elucidate the molecular mechanisms for more common forms of the human diseases.

    We use unique resources in several genetic isolates and limited human populations. Large pedigrees of human families with autosomal-dominant and autosomal-recessive diseases with unknown gene defects are being collected . Currently, we apply strategies of positional cloning and direct screening of candidate-genes for variety of human diseases, including eg., morbid obesity with hyperphagia, a specific case of premature aging, eye-diseases, alopecia (baldness) and others.


    Collapse Post Docs

    A postdoctoral position is available to study in this laboratory. Contact Dr. Rogaev for additional details.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Andreeva TV, Manakhov AD, Gusev FE, Patrikeev AD, Golovanova LV, Doronichev VB, Shirobokov IG, Rogaev EI. Genomic analysis of a novel Neanderthal from Mezmaiskaya Cave provides insights into the genetic relationships of Middle Palaeolithic populations. Sci Rep. 2022 07 29; 12(1):13016. PMID: 35906446.
      Citations:    Fields:    
    2. Manakhov AD, Mintseva MY, Uralsky LI, Andreeva TV, Trapezov OV, Rogaev EI. Identification of mutant gene for Black crystal coat and non-allelic gene interactions in Neogale vison. Sci Rep. 2022 06 21; 12(1):10483. PMID: 35729186.
      Citations:    Fields:    Translation:Animals
    3. Manakhov AD, Mintseva MY, Andreeva TV, Trapezov OV, Rogaev EI. Shadow coat colour in American mink associated with a missense mutation in the KIT gene. Anim Genet. 2022 Aug; 53(4):522-525. PMID: 35481560.
      Citations:    Fields:    Translation:Animals
    4. Altemose N, Logsdon GA, Bzikadze AV, Sidhwani P, Langley SA, Caldas GV, Hoyt SJ, Uralsky L, Ryabov FD, Shew CJ, Sauria MEG, Borchers M, Gershman A, Mikheenko A, Shepelev VA, Dvorkina T, Kunyavskaya O, Vollger MR, Rhie A, McCartney AM, Asri M, Lorig-Roach R, Shafin K, Lucas JK, Aganezov S, Olson D, de Lima LG, Potapova T, Hartley GA, Haukness M, Kerpedjiev P, Gusev F, Tigyi K, Brooks S, Young A, Nurk S, Koren S, Salama SR, Paten B, Rogaev EI, Streets A, Karpen GH, Dernburg AF, Sullivan BA, Straight AF, Wheeler TJ, Gerton JL, Eichler EE, Phillippy AM, Timp W, Dennis MY, O'Neill RJ, Zook JM, Schatz MC, Pevzner PA, Diekhans M, Langley CH, Alexandrov IA, Miga KH. Complete genomic and epigenetic maps of human centromeres. Science. 2022 04; 376(6588):eabl4178. PMID: 35357911.
      Citations: 17     Fields:    Translation:HumansCells
    5. Nurk S, Koren S, Rhie A, Rautiainen M, Bzikadze AV, Mikheenko A, Vollger MR, Altemose N, Uralsky L, Gershman A, Aganezov S, Hoyt SJ, Diekhans M, Logsdon GA, Alonge M, Antonarakis SE, Borchers M, Bouffard GG, Brooks SY, Caldas GV, Chen NC, Cheng H, Chin CS, Chow W, de Lima LG, Dishuck PC, Durbin R, Dvorkina T, Fiddes IT, Formenti G, Fulton RS, Fungtammasan A, Garrison E, Grady PGS, Graves-Lindsay TA, Hall IM, Hansen NF, Hartley GA, Haukness M, Howe K, Hunkapiller MW, Jain C, Jain M, Jarvis ED, Kerpedjiev P, Kirsche M, Kolmogorov M, Korlach J, Kremitzki M, Li H, Maduro VV, Marschall T, McCartney AM, McDaniel J, Miller DE, Mullikin JC, Myers EW, Olson ND, Paten B, Peluso P, Pevzner PA, Porubsky D, Potapova T, Rogaev EI, Rosenfeld JA, Salzberg SL, Schneider VA, Sedlazeck FJ, Shafin K, Shew CJ, Shumate A, Sims Y, Smit AFA, Soto DC, Sovi? I, Storer JM, Streets A, Sullivan BA, Thibaud-Nissen F, Torrance J, Wagner J, Walenz BP, Wenger A, Wood JMD, Xiao C, Yan SM, Young AC, Zarate S, Surti U, McCoy RC, Dennis MY, Alexandrov IA, Gerton JL, O'Neill RJ, Timp W, Zook JM, Schatz MC, Eichler EE, Miga KH, Phillippy AM. The complete sequence of a human genome. Science. 2022 04; 376(6588):44-53. PMID: 35357919.
      Citations: 53     Fields:    Translation:HumansCells
    6. Protasova MS, Gusev FE, Andreeva TV, Klyushnikov SA, Illarioshkin SN, Rogaev EI. Novel genes bearing mutations in rare cases of early-onset ataxia with cerebellar hypoplasia. Eur J Hum Genet. 2022 06; 30(6):703-711. PMID: 35351988.
      Citations: 1     Fields:    Translation:Humans
    7. Erofeeva TV, Grigorenko AP, Gusev FE, Kosevich IA, Rogaev EI. Studying of Molecular Regulation of Developmental Processes of Lower Metazoans Exemplified by Cnidaria Using High-Throughput Sequencing. Biochemistry (Mosc). 2022 Mar; 87(3):269-293. PMID: 35526848.
      Citations:    Fields:    Translation:AnimalsCells
    8. Malyarchuk AB, Andreeva TV, Kuznetsova IL, Kunizheva SS, Protasova MS, Uralsky LI, Tyazhelova TV, Gusev FE, Manakhov AD, Rogaev EI. Genomics of Ancient Pathogens: First Advances and Prospects. Biochemistry (Mosc). 2022 Mar; 87(3):242-258. PMID: 35526849.
      Citations:    Fields:    Translation:HumansCells
    9. Grigorenko AP, Protasova MS, Lisenkova AA, Reshetov DA, Andreeva TV, Garcias GL, Martino Roth MDG, Papassotiropoulos A, Rogaev EI. Neurodevelopmental Syndrome with Intellectual Disability, Speech Impairment, and Quadrupedia Is Associated with Glutamate Receptor Delta 2 Gene Defect. Cells. 2022 01 25; 11(3). PMID: 35159210.
      Citations:    Fields:    Translation:Humans
    10. Kuznetsova IL, Ponomareva NV, Alemastseva EA, Manakhov AD, Andreeva TV, Gusev FE, Rogaev EI. The Interactive Effect of Genetic and Epigenetic Variations in FKBP5 and ApoE Genes on Anxiety and Brain EEG Parameters. Genes (Basel). 2022 01 18; 13(2). PMID: 35205209.
      Citations:    Fields:    Translation:Humans
    11. Andreeva T, Manakhov A, Kunizheva S, Rogaev E. Genetic Evidence of Authenticity of a Hair Shaft Relic from the Portrait of Tsesarevich Alexei, Son of the Last Russian Emperor. Biochemistry (Mosc). 2021 Dec; 86(12):1572-1578. PMID: 34937536.
      Citations:    Fields:    Translation:Humans
    12. Protasova MS, Andreeva TV, Rogaev EI. Factors Regulating the Activity of LINE1 Retrotransposons. Genes (Basel). 2021 09 30; 12(10). PMID: 34680956.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    13. Yukina M, Erofeeva T, Nuralieva N, Andreeva T, Savvateeva E, Dudko N, Troshina E, Rogaev E, Melnichenko G. Novel Gene Mutations Regulating Immune Responses in Autoimmune Polyglandular Syndrome With an Atypical Course. J Endocr Soc. 2021 Aug 01; 5(8):bvab077. PMID: 34235359.
      Citations:    
    14. Kim K, Wang X, Ragonnaud E, Bodogai M, Illouz T, DeLuca M, McDevitt RA, Gusev F, Okun E, Rogaev E, Biragyn A. Therapeutic B-cell depletion reverses progression of Alzheimer's disease. Nat Commun. 2021 04 12; 12(1):2185. PMID: 33846335.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    15. Manakhov AD, Mintseva MY, Andreeva TV, Filimonov PA, Onokhov AA, Chernova I?, Kashtanov SN, Rogaev EI. Genome Analysis of Sable Fur Color Links a Lightened Pigmentation Phenotype to a Frameshift Variant in the Tyrosinase-Related Protein 1 Gene. Genes (Basel). 2021 01 25; 12(2). PMID: 33503951.
      Citations:    Fields:    Translation:Animals
    16. Manakhov AD, Mintseva MY, Andreev IA, Uralsky LI, Andreeva TV, Trapezov OV, Rogaev EI. Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype. Sci Rep. 2020 09 28; 10(1):15876. PMID: 32985525.
      Citations: 2     Fields:    Translation:AnimalsCells
    17. Manakhov AD, Andreeva TV, Rogaev EI. The curly coat phenotype of the Ural Rex feline breed is associated with a mutation in the lipase H gene. Anim Genet. 2020 Aug; 51(4):584-589. PMID: 32463158.
      Citations: 3     Fields:    Translation:Animals
    18. Ponomareva N, Andreeva T, Protasova M, Konovalov R, Krotenkova M, Malina D, Mitrofanov A, Fokin V, Illarioshkin S, Rogaev E. Genetic Association Between Alzheimer's Disease Risk Variant of the PICALM Gene and EEG Functional Connectivity in Non-demented Adults. Front Neurosci. 2020; 14:324. PMID: 32372909.
      Citations:    
    19. Aliseychik M, Patrikeev A, Gusev F, Grigorenko A, Andreeva T, Biragyn A, Rogaev E. Dissection of the Human T-Cell Receptor ? Gene Repertoire in the Brain and Peripheral Blood Identifies Age- and Alzheimer's Disease-Associated Clonotype Profiles. Front Immunol. 2020; 11:12. PMID: 32117220.
      Citations: 4     Fields:    Translation:HumansCells
    20. Gusev FE, Reshetov DA, Mitchell AC, Andreeva TV, Dincer A, Grigorenko AP, Fedonin G, Halene T, Aliseychik M, Filippova E, Weng Z, Akbarian S, Rogaev EI. Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia. Transl Psychiatry. 2019 10 17; 9(1):256. PMID: 31624234.
      Citations: 6     Fields:    Translation:HumansCells
    21. Ragonnaud E, Moritoh K, Bodogai M, Gusev F, Garaud S, Chen C, Wang X, Baljinnyam T, Becker KG, Maul RW, Willard-Gallo K, Rogaev E, Biragyn A. Tumor-Derived Thymic Stromal Lymphopoietin Expands Bone Marrow B-cell Precursors in Circulation to Support Metastasis. Cancer Res. 2019 Nov 15; 79(22):5826-5838. PMID: 31575547.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    22. Gusev FE, Reshetov DA, Mitchell AC, Andreeva TV, Dincer A, Grigorenko AP, Fedonin G, Halene T, Aliseychik M, Goltsov AY, Solovyev V, Brizgalov L, Filippova E, Weng Z, Akbarian S, Rogaev EI. Epigenetic-genetic chromatin footprinting identifies novel and subject-specific genes active in prefrontal cortex neurons. FASEB J. 2019 07; 33(7):8161-8173. PMID: 30970224.
      Citations: 4     Fields:    Translation:HumansCells
    23. Manakhov AD, Andreeva TV, Trapezov OV, Kolchanov NA, Rogaev EI. Genome analysis identifies the mutant genes for common industrial Silverblue and Hedlund white coat colours in American mink. Sci Rep. 2019 03 14; 9(1):4581. PMID: 30872653.
      Citations: 4     Fields:    Translation:AnimalsCells
    24. Uralsky LI, Shepelev VA, Alexandrov AA, Yurov YB, Rogaev EI, Alexandrov IA. Classification and monomer-by-monomer annotation dataset of suprachromosomal family 1 alpha satellite higher-order repeats in hg38 human genome assembly. Data Brief. 2019 Jun; 24:103708. PMID: 30989093.
      Citations:    
    25. Biragyn A, Aliseychik M, Rogaev E. Correction to: Potential importance of B cells in aging and aging-associated neurodegenerative diseases. Semin Immunopathol. 2019 Mar; 41(2):277. PMID: 30643988.
      Citations:    Fields:    
    26. Bodogai M, O'Connell J, Kim K, Kim Y, Moritoh K, Chen C, Gusev F, Vaughan K, Shulzhenko N, Mattison JA, Lee-Chang C, Chen W, Carlson O, Becker KG, Gurung M, Morgun A, White J, Meade T, Perdue K, Mack M, Ferrucci L, Trinchieri G, de Cabo R, Rogaev E, Egan J, Wu J, Biragyn A. Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells. Sci Transl Med. 2018 11 14; 10(467). PMID: 30429354.
      Citations: 54     Fields:    Translation:AnimalsCells
    27. Rogaev EI. Different Pathways to Neurodegeneration. Biochemistry (Mosc). 2018 Sep; 83(9):1007-1008. PMID: 30472938.
      Citations: 1     Fields:    Translation:HumansCells
    28. Aliseychik MP, Andreeva TV, Rogaev EI. Immunogenetic Factors of Neurodegenerative Diseases: The Role of HLA Class II. Biochemistry (Mosc). 2018 Sep; 83(9):1104-1116. PMID: 30472949.
      Citations: 7     Fields:    Translation:Humans
    29. Ponomareva NV, Andreeva TV, Protasova MA, Filippova YV, Kolesnikova EP, Fokin VF, Illarioshkin SN, Rogaev EI. Genetic Association between Alzheimer's Disease Risk Variant of the PICALM Gene and Auditory Event-Related Potentials in Aging. Biochemistry (Mosc). 2018 Sep; 83(9):1075-1082. PMID: 30472946.
      Citations: 2     Fields:    Translation:Humans
    30. Bryzgalov DV, Kuznetsova IL, Rogaev EI. Enhancement of Declarative Memory: From Genetic Regulation to Non-invasive Stimulation. Biochemistry (Mosc). 2018 Sep; 83(9):1124-1138. PMID: 30472951.
      Citations: 1     Fields:    Translation:HumansAnimals
    31. Babenko VN, Afonnikov DA, Ignatieva EV, Klimov AV, Gusev FE, Rogaev EI. Haplotype analysis of APOE intragenic SNPs. BMC Neurosci. 2018 04 19; 19(Suppl 1):16. PMID: 29745836.
      Citations: 21     Fields:    Translation:HumansCells
    32. Pilsner JR, Shershebnev A, Medvedeva YA, Suvorov A, Wu H, Goltsov A, Loukianov E, Andreeva T, Gusev F, Manakhov A, Smigulina L, Logacheva M, Shtratnikova V, Kuznetsova I, Speranskiy-Podobed P, Burns JS, Williams PL, Korrick S, Lee MM, Rogaev E, Hauser R, Sergeyev O. Peripubertal serum dioxin concentrations and subsequent sperm methylome profiles of young Russian adults. Reprod Toxicol. 2018 06; 78:40-49. PMID: 29550351.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    33. Saik OV, Demenkov PS, Ivanisenko TV, Bragina EY, Freidin MB, Goncharova IA, Dosenko VE, Zolotareva OI, Hofestaedt R, Lavrik IN, Rogaev EI, Ivanisenko VA. Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks. BMC Med Genomics. 2018 02 13; 11(Suppl 1):15. PMID: 29504915.
      Citations: 16     Fields:    Translation:Humans
    34. Protasova MS, Gusev FE, Grigorenko AP, Kuznetsova IL, Rogaev EI, Andreeva TV. Quantitative Analysis of L1-Retrotransposons in Alzheimer's Disease and Aging. Biochemistry (Mosc). 2017 Aug; 82(8):962-971. PMID: 28941465.
      Citations: 16     Fields:    Translation:HumansCells
    35. Grigorenko AP, Moliaka YK, Plotnikova OV, Smirnov A, Nikishina VA, Goltsov AY, Gusev F, Andreeva TV, Nelson O, Bezprozvanny I, Rogaev EI. Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease. Oncotarget. 2017 Oct 10; 8(47):82006-82026. PMID: 29137240.
      Citations:    Fields:    
    36. Bondar N, Bryzgalov L, Ershov N, Gusev F, Reshetnikov V, Avgustinovich D, Tenditnik M, Rogaev E, Merkulova T. Molecular Adaptations to Social Defeat Stress and Induced Depression in Mice. Mol Neurobiol. 2018 Apr; 55(4):3394-3407. PMID: 28500512.
      Citations: 13     Fields:    Translation:AnimalsCells
    37. Lukiw WJ, Rogaev EI. Genetics of Aggression in Alzheimer's Disease (AD). Front Aging Neurosci. 2017; 9:87. PMID: 28443016.
      Citations:    
    38. Gunbin KV, Ponomarenko MP, Suslov VV, Gusev F, Fedonin GG, Rogaev EI. Evolution of Brain Active Gene Promoters in Human Lineage Towards the Increased Plasticity of Gene Regulation. Mol Neurobiol. 2018 03; 55(3):1871-1904. PMID: 28233272.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    39. Andreeva TV, Lukiw WJ, Rogaev EI. Biological Basis for Amyloidogenesis in Alzheimer's Disease. Biochemistry (Mosc). 2017 Feb; 82(2):122-139. PMID: 28320296.
      Citations: 11     Fields:    Translation:HumansAnimals
    40. Biragyn A, Aliseychik M, Rogaev E. Potential importance of B cells in aging and aging-associated neurodegenerative diseases. Semin Immunopathol. 2017 04; 39(3):283-294. PMID: 28083646.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    41. Ignatieva EV, Afonnikov DA, Saik OV, Rogaev EI, Kolchanov NA. A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network. BMC Genet. 2016 12 22; 17(Suppl 3):158. PMID: 28105929.
      Citations: 7     Fields:    Translation:Humans
    42. Ponomareva NV, Andreeva TV, Protasova MS, Shagam LI, Malina DD, Goltsov AY, Fokin VF, Illarioshkin SN, Rogaev EI. Quantitative EEG during normal aging: association with the Alzheimer's disease genetic risk variant in PICALM gene. Neurobiol Aging. 2017 03; 51:177.e1-177.e8. PMID: 28073596.
      Citations: 5     Fields:    Translation:Humans
    43. Lisenkova AA, Grigorenko AP, Tyazhelova TV, Andreeva TV, Gusev FE, Manakhov AD, Goltsov AY, Piraino S, Miglietta MP, Rogaev EI. Complete mitochondrial genome and evolutionary analysis of Turritopsis dohrnii, the "immortal" jellyfish with a reversible life-cycle. Mol Phylogenet Evol. 2017 02; 107:232-238. PMID: 27845203.
      Citations: 4     Fields:    Translation:AnimalsCells
    44. Morozova I, Flegontov P, Mikheyev AS, Bruskin S, Asgharian H, Ponomarenko P, Klyuchnikov V, ArunKumar G, Prokhortchouk E, Gankin Y, Rogaev E, Nikolsky Y, Baranova A, Elhaik E, Tatarinova TV. Toward high-resolution population genomics using archaeological samples. DNA Res. 2016 Aug; 23(4):295-310. PMID: 27436340.
      Citations: 7     Fields:    Translation:HumansAnimals
    45. Ziccardi W, Zhao C, Shepelev V, Uralsky L, Alexandrov I, Andreeva T, Rogaev E, Bun C, Miller E, Putonti C, Doering J. Clusters of alpha satellite on human chromosome 21 are dispersed far onto the short arm and lack ancient layers. Chromosome Res. 2016 09; 24(3):421-36. PMID: 27430641.
      Citations: 3     Fields:    Translation:HumansCells
    46. Andreeva TV, Tyazhelova TV, Rykalina VN, Gusev FE, Goltsov AY, Zolotareva OI, Aliseichik MP, Borodina TA, Grigorenko AP, Reshetov DA, Ginter EK, Amelina SS, Zinchenko RA, Rogaev EI. Whole exome sequencing links dental tumor to an autosomal-dominant mutation in ANO5 gene associated with gnathodiaphyseal dysplasia and muscle dystrophies. Sci Rep. 2016 05 24; 6:26440. PMID: 27216912.
      Citations: 10     Fields:    Translation:Humans
    47. Bhattacharjee S, Zhao Y, Dua P, Rogaev EI, Lukiw WJ. microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration. PLoS One. 2016; 11(3):e0150211. PMID: 26949937.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    48. Shepelev VA, Uralsky LI, Alexandrov AA, Yurov YB, Rogaev EI, Alexandrov IA. Annotation of suprachromosomal families reveals uncommon types of alpha satellite organization in pericentromeric regions of hg38 human genome assembly. Genom Data. 2015 Sep 01; 5:139-146. PMID: 26167452.
      Citations:    
    49. Protasova MS, Grigorenko AP, Tyazhelova TV, Andreeva TV, Reshetov DA, Gusev FE, Laptenko AE, Kuznetsova IL, Goltsov AY, Klyushnikov SA, Illarioshkin SN, Rogaev EI. Whole-genome sequencing identifies a novel ABCB7 gene mutation for X-linked congenital cerebellar ataxia in a large family of Mongolian ancestry. Eur J Hum Genet. 2016 Apr; 24(4):550-5. PMID: 26242992.
      Citations: 13     Fields:    Translation:Humans
    50. Bai G, Cheung I, Shulha HP, Coelho JE, Li P, Dong X, Jakovcevski M, Wang Y, Grigorenko A, Jiang Y, Hoss A, Patel K, Zheng M, Rogaev E, Myers RH, Weng Z, Akbarian S, Chen JF. Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. Hum Mol Genet. 2015 Mar 01; 24(5):1441-56. PMID: 25480889.
      Citations: 29     Fields:    Translation:HumansCells
    51. Rykalina VN, Shadrin AA, Amstislavskiy VS, Rogaev EI, Lehrach H, Borodina TA. Exome sequencing from nanogram amounts of starting DNA: comparing three approaches. PLoS One. 2014; 9(7):e101154. PMID: 24992588.
      Citations: 14     Fields:    Translation:Humans
    52. Moroz LL, Kocot KM, Citarella MR, Dosung S, Norekian TP, Povolotskaya IS, Grigorenko AP, Dailey C, Berezikov E, Buckley KM, Ptitsyn A, Reshetov D, Mukherjee K, Moroz TP, Bobkova Y, Yu F, Kapitonov VV, Jurka J, Bobkov YV, Swore JJ, Girardo DO, Fodor A, Gusev F, Sanford R, Bruders R, Kittler E, Mills CE, Rast JP, Derelle R, Solovyev VV, Kondrashov FA, Swalla BJ, Sweedler JV, Rogaev EI, Halanych KM, Kohn AB. The ctenophore genome and the evolutionary origins of neural systems. Nature. 2014 Jun 05; 510(7503):109-14. PMID: 24847885.
      Citations: 227     Fields:    Translation:AnimalsCells
    53. Ponomareva N, Andreeva T, Protasova M, Shagam L, Malina D, Goltsov A, Fokin V, Mitrofanov A, Rogaev E. Age-dependent effect of Alzheimer's risk variant of CLU on EEG alpha rhythm in non-demented adults. Front Aging Neurosci. 2013; 5:86. PMID: 24379779.
      Citations:    
    54. Nizamutdinov II, Andreeva TV, Stepanov VA, Marusin AV, Rogaev EI, Zasedatelev AS, Nasedkina TV. [Biochip for determination of genetic markers of sporadic Alzheimer's disease in the Russian Slavic population]. Mol Biol (Mosk). 2013 Nov-Dec; 47(6):949-58. PMID: 25509857.
      Citations: 4     Fields:    Translation:Humans
    55. Lukiw WJ, Andreeva TV, Grigorenko AP, Rogaev EI. Studying micro RNA Function and Dysfunction in Alzheimer's Disease. Front Genet. 2012; 3:327. PMID: 23390425.
      Citations:    
    56. Shulha HP, Crisci JL, Reshetov D, Tushir JS, Cheung I, Bharadwaj R, Chou HJ, Houston IB, Peter CJ, Mitchell AC, Yao WD, Myers RH, Chen JF, Preuss TM, Rogaev EI, Jensen JD, Weng Z, Akbarian S. Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol. 2012; 10(11):e1001427. PMID: 23185133.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    57. Houston I, Peter CJ, Mitchell A, Straubhaar J, Rogaev E, Akbarian S. Epigenetics in the human brain. Neuropsychopharmacology. 2013 Jan; 38(1):183-97. PMID: 22643929.
      Citations: 35     Fields:    Translation:HumansCells
    58. Rogaev EI. Genomics of behavioral diseases. Front Genet. 2012; 3:45. PMID: 22485117.
      Citations:    
    59. Selezneva ND, Roshchina IF, Gavrilova SI, Fedorova IaB, Gantman MV, Korova?tseva GI, Kunizheva SS, Rogaev EI. [Mental disorders of cognitive and non-cognitive spectrum in the first-degree relatives of patients with Alzheimer's disease]. Zh Nevrol Psikhiatr Im S S Korsakova. 2012; 112(10):8-13. PMID: 23250590.
      Citations:    Fields:    Translation:Humans
    60. Ponomareva NV, Goltsov AY, Kunijeva SS, Scheglova NS, Malina DD, Mitrofanov AA, Boikova TI, Rogaev EI. Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults. Neurobiol Aging. 2012 Apr; 33(4):839.e11-21. PMID: 22206848.
      Citations: 3     Fields:    Translation:Humans
    61. Berdichevets IN, Tyazhelova TV, Shimshilashvili KhR, Rogaev EI. Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action. Biochemistry (Mosc). 2010 Sep; 75(9):1088-97. PMID: 21077828.
      Citations: 4     Fields:    Translation:Humans
    62. Mellios N, Galdzicka M, Ginns E, Baker SP, Rogaev E, Xu J, Akbarian S. Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia. Schizophr Bull. 2012 May; 38(3):433-43. PMID: 20732949.
      Citations: 38     Fields:    Translation:HumansAnimals
    63. Golenkina SA, Gol'tsov AIu, Kuznetsova IL, Grigorenko AP, Andreeva TV, Reshetov DA, Kunizheva SS, Shagam LI, Morozova IIu, Goldenkova-Pavlova IV, Shimshilashvili Kh, Viacheslavova AO, Faskhutdinova G, Gareeva AÉ, Za?nullina AG, Khusnutdinova ÉK, Puzyrev VP, Stepanov VA, Kolotvin AV, Samokhodskaia LM, Selezneva ND, Gavrilova SI, Rogaev EI. [Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations]. Mol Biol (Mosk). 2010 Jul-Aug; 44(4):620-6. PMID: 20873220.
      Citations: 10     Fields:    Translation:Humans
    64. Underhill PA, Myres NM, Rootsi S, Metspalu M, Zhivotovsky LA, King RJ, Lin AA, Chow CE, Semino O, Battaglia V, Kutuev I, Järve M, Chaubey G, Ayub Q, Mohyuddin A, Mehdi SQ, Sengupta S, Rogaev EI, Khusnutdinova EK, Pshenichnov A, Balanovsky O, Balanovska E, Jeran N, Augustin DH, Baldovic M, Herrera RJ, Thangaraj K, Singh V, Singh L, Majumder P, Rudan P, Primorac D, Villems R, Kivisild T. Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a. Eur J Hum Genet. 2010 Apr; 18(4):479-84. PMID: 19888303.
      Citations: 60     Fields:    Translation:HumansCells
    65. Rogaev EI, Grigorenko AP, Faskhutdinova G, Kittler EL, Moliaka YK. Genotype analysis identifies the cause of the "royal disease". Science. 2009 Nov 06; 326(5954):817. PMID: 19815722.
      Citations: 26     Fields:    Translation:HumansCells
    66. Grigorenko AP, Borinskaya SA, Yankovsky NK, Rogaev EI. Achievements and peculiarities in studies of ancient DNA and DNA from complicated forensic specimens. Acta Naturae. 2009 Oct; 1(3):58-69. PMID: 22649615.
      Citations:    
    67. Järve M, Zhivotovsky LA, Rootsi S, Help H, Rogaev EI, Khusnutdinova EK, Kivisild T, Sanchez JJ. Decreased rate of evolution in Y chromosome STR loci of increased size of the repeat unit. PLoS One. 2009 Sep 30; 4(9):e7276. PMID: 19789645.
      Citations: 4     Fields:    Translation:HumansCells
    68. Li H, Borinskaya S, Yoshimura K, Kal'ina N, Marusin A, Stepanov VA, Qin Z, Khaliq S, Lee MY, Yang Y, Mohyuddin A, Gurwitz D, Mehdi SQ, Rogaev E, Jin L, Yankovsky NK, Kidd JR, Kidd KK. Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant. Ann Hum Genet. 2009 May; 73(Pt 3):335-45. PMID: 19456322.
      Citations: 99     Fields:    Translation:Humans
    69. Rogaev EI, Grigorenko AP, Moliaka YK, Faskhutdinova G, Goltsov A, Lahti A, Hildebrandt C, Kittler EL, Morozova I. Genomic identification in the historical case of the Nicholas II royal family. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5258-63. PMID: 19251637.
      Citations: 11     Fields:    Translation:Humans
    70. Borinskaya S, Kal'ina N, Marusin A, Faskhutdinova G, Morozova I, Kutuev I, Koshechkin V, Khusnutdinova E, Stepanov V, Puzyrev V, Yankovsky N, Rogaev E. Distribution of the alcohol dehydrogenase ADH1B*47His allele in Eurasia. Am J Hum Genet. 2009 Jan; 84(1):89-92; author reply 92-4. PMID: 19124091.
      Citations: 12     Fields:    Translation:Humans
    71. Rogaev EI, Borinskaia SA, Islamgulov DV, Grigorenko AP. [Human microRNA in norm and pathology]. Mol Biol (Mosk). 2008 Sep-Oct; 42(5):751-64. PMID: 18988525.
      Citations: 1     Fields:    Translation:Humans
    72. Mellios N, Huang HS, Grigorenko A, Rogaev E, Akbarian S. A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Hum Mol Genet. 2008 Oct 01; 17(19):3030-42. PMID: 18632683.
      Citations: 128     Fields:    Translation:HumansCells
    73. Borinskaia SA, Kal'ina NR, Sanina ED, Kozhekbaeva ZhM, Gupalo EIu, Garmash IV, Ogurtsov PP, Parshukova ON, Bo?ko SG, Veselovski? EM, Vershubskaia GG, Kozlov AI, Rogaev EI, Iankovski? NK. [Polymorphism of the apolipoprotein E gene (APOE) in the populations of Russia and neighboring countries]. Genetika. 2007 Oct; 43(10):1434-40. PMID: 18069348.
      Citations: 1     Fields:    Translation:Humans
    74. Plotnikova OV, Kondrashov FA, Vlasov PK, Grigorenko AP, Ginter EK, Rogaev EI. Conversion and compensatory evolution of the gamma-crystallin genes and identification of a cataractogenic mutation that reverses the sequence of the human CRYGD gene to an ancestral state. Am J Hum Genet. 2007 Jul; 81(1):32-43. PMID: 17564961.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    75. Burmistrova OA, Goltsov AY, Abramova LI, Kaleda VG, Orlova VA, Rogaev EI. MicroRNA in schizophrenia: genetic and expression analysis of miR-130b (22q11). Biochemistry (Mosc). 2007 May; 72(5):578-82. PMID: 17573714.
      Citations: 60     Fields:    Translation:HumansCells
    76. Grigorenko AP, Rogaev EI. [Molecular basics of Alzheimer's disease]. Mol Biol (Mosk). 2007 Mar-Apr; 41(2):331-45. PMID: 17514900.
      Citations: 3     Fields:    Translation:HumansCells
    77. Ponomareva NV, Korovaitseva GI, Rogaev EI. EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease. Neurobiol Aging. 2008 Jun; 29(6):819-27. PMID: 17293007.
      Citations: 28     Fields:    Translation:Humans
    78. Kazantseva A, Goltsov A, Zinchenko R, Grigorenko AP, Abrukova AV, Moliaka YK, Kirillov AG, Guo Z, Lyle S, Ginter EK, Rogaev EI. Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH. Science. 2006 Nov 10; 314(5801):982-5. PMID: 17095700.
      Citations: 53     Fields:    Translation:HumansCells
    79. Goltsov AY, Loseva JG, Andreeva TV, Grigorenko AP, Abramova LI, Kaleda VG, Orlova VA, Moliaka YK, Rogaev EI. Polymorphism in the 5'-promoter region of serine racemase gene in schizophrenia. Mol Psychiatry. 2006 Apr; 11(4):325-6. PMID: 16446740.
      Citations: 20     Fields:    Translation:HumansCells
    80. Rogaev EI, Moliaka YK, Malyarchuk BA, Kondrashov FA, Derenko MV, Chumakov I, Grigorenko AP. Complete mitochondrial genome and phylogeny of Pleistocene mammoth Mammuthus primigenius. PLoS Biol. 2006 Mar; 4(3):e73. PMID: 16448217.
      Citations: 33     Fields:    Translation:Animals
    81. Rogaev EI. Small RNAs in human brain development and disorders. Biochemistry (Mosc). 2005 Dec; 70(12):1404-7. PMID: 16417465.
      Citations: 19     Fields:    Translation:Humans
    82. Golimbet VE, Lebedeva IS, Gritsenko IK, Korova?tseva GI, Alfimova MV, Lezhe?ko TV, Abramova LI, Kaleda VG, Ebshte?n RP, Rogaev EI. [A study of some genes related to serotoninergic and dopaminergic systems and auditory evoked-potentials (P300) in patients with schizophrenia and spectrum disorders and their first-degree relatives]. Zh Nevrol Psikhiatr Im S S Korsakova. 2005; 105(10):35-41. PMID: 16281377.
      Citations: 2     Fields:    Translation:HumansCells
    83. Papassotiropoulos A, Lambert JC, Wavrant-De Vrièze F, Wollmer MA, von der Kammer H, Streffer JR, Maddalena A, Huynh KD, Wolleb S, Lutjohann D, Schneider B, Thal DR, Grimaldi LM, Tsolaki M, Kapaki E, Ravid R, Konietzko U, Hegi T, Pasch T, Jung H, Braak H, Amouyel P, Rogaev EI, Hardy J, Hock C, Nitsch RM. Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease. Neurodegener Dis. 2005; 2(5):233-41. PMID: 16909003.
      Citations: 27     Fields:    Translation:HumansCells
    84. Grigorenko AP, Moliaka YK, Soto MC, Mello CC, Rogaev EI. The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14955-60. PMID: 15469912.
      Citations: 23     Fields:    Translation:AnimalsCells
    85. Chen F, Wollmer MA, Hoerndli F, Münch G, Kuhla B, Rogaev EI, Tsolaki M, Papassotiropoulos A, Götz J. Role for glyoxalase I in Alzheimer's disease. Proc Natl Acad Sci U S A. 2004 May 18; 101(20):7687-92. PMID: 15128939.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    86. Golimbet VE, Alfimova MV, Shchebatykh TV, Abramova LI, Kaleda VG, Rogaev EI. Serotonin transporter polymorphism and depressive-related symptoms in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 01; 126B(1):1-7. PMID: 15048639.
      Citations: 4     Fields:    Translation:Humans
    87. Moliaka YK, Grigorenko A, Madera D, Rogaev EI. Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein. FEBS Lett. 2004 Jan 16; 557(1-3):185-92. PMID: 14741365.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    88. Bobrysheva IV, Grigorenko AP, Novosadova EV, Kal'ina NR, Arsenyeva EL, Grivennikov IA, Tarantul VZ, Rogaev EI. Effects of human presenilin 1 isoforms on proliferation and survival of rat pheochromocytoma cell line PC12. Biochemistry (Mosc). 2003 Jun; 68(6):611-7. PMID: 12943504.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    89. Golimbet VE, Alfimova MV, Shcherbatykh TV, Rogaev EI. [Gene insertion and deletion polymorphism in the serotonin transporter gene and personality traits measured by MMPI]. Genetika. 2003 Apr; 39(4):534-9. PMID: 12760255.
      Citations: 1     Fields:    Translation:Humans
    90. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen-Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin-Saumier S, Nasroune M, Peixoto H, Delaye A, Pinchot V, Bastucci M, Guillou S, Chevillon M, Sainz-Fuertes R, Meguenni S, Aurich-Costa J, Cherif D, Gimalac A, Van Duijn C, Gauvreau D, Ouellette G, Fortier I, Raelson J, Sherbatich T, Riazanskaia N, Rogaev E, Raeymaekers P, Aerssens J, Konings F, Luyten W, Macciardi F, Sham PC, Straub RE, Weinberger DR, Cohen N, Cohen D, Ouelette G, Realson J. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13675-80. PMID: 12364586.
      Citations: 221     Fields:    Translation:HumansCells
    91. Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI. Novel class of polytopic proteins with domains associated with putative protease activity. Biochemistry (Mosc). 2002 Jul; 67(7):826-35. PMID: 12139484.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    92. Golimbet VE, Alfimova MV, Shcherbatykh TV, Rogaev EI. [Allele polymorphism of the serotonin transporter gene and clinical heterogeneity of depressive disorders]. Genetika. 2002 May; 38(5):671-7. PMID: 12068552.
      Citations:    Fields:    Translation:Humans
    93. Maliarchuk BA, Derenko MV, Denisova GA, Nassiri MR, Rogaev EI. [Mitochondrial DNA polymorphism in populations of the Caspian region and southeastern Europe]. Genetika. 2002 Apr; 38(4):534-8. PMID: 12018172.
      Citations:    Fields:    Translation:Humans
    94. Iatsyshina SB, Moliaka IuK, Karpova SK, Chekhranova MK, Popova IuP, Grigorian ON, Pankov IuA, Rogaev EI. [Study of the association between constitutional exogenous obesity and polymorphism of the apolipoprotein B gene]. Genetika. 2002 Feb; 38(2):285-8. PMID: 11898622.
      Citations:    Fields:    Translation:Humans
    95. Pankov IuA, Iatsyshina SB, Karpova SK, Chekhranova MK, Popova IuP, Grigorian ON, Rogaev EI. [Screening of mutations in genes of pro-opiomelanocortin in patients with constitutional exogenous obesity]. Vopr Med Khim. 2002 Jan-Feb; 48(1):121-30. PMID: 12068494.
      Citations: 5     Fields:    Translation:Humans
    96. Maliarchuk BA, Denisova GA, Derenko MV, Rogaev EI, Vlasenko LV, Zhukova SG. [Variability in mitochondrial DNA in Russian inhabitants from Krasnodar Krai, Belgorod and the lower Novgorod region]. Genetika. 2001 Oct; 37(10):1411-6. PMID: 11761619.
      Citations: 2     Fields:    Translation:Humans
    97. Nicolaou M, Song YQ, Sato CA, Orlacchio A, Kawarai T, Medeiros H, Liang Y, Sorbi S, Richard E, Rogaev EI, Moliaka Y, Bruni AC, Jorge R, Percy M, Duara R, Farrer LA, St Georg-Hyslop P, Rogaeva EA. Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease. Neurogenetics. 2001 Oct; 3(4):203-6. PMID: 11714100.
      Citations: 13     Fields:    Translation:Humans
    98. Rogaeva EA, Fafel KC, Song YQ, Medeiros H, Sato C, Liang Y, Richard E, Rogaev EI, Frommelt P, Sadovnick AD, Meschino W, Rockwood K, Boss MA, Mayeux R, St George-Hyslop P. Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations. Neurology. 2001 Aug 28; 57(4):621-5. PMID: 11524469.
      Citations: 59     Fields:    Translation:Humans
    99. Ginter EK, Kirillov AG, Rogaev EI. [Autosomal-dominant osteopetrosis in Chuvashiya]. Genetika. 2001 Aug; 37(8):1152-5. PMID: 11642116.
      Citations: 1     Fields:    Translation:Humans
    100. Korova?tseva GI, Shcherbatykh TV, Selezneva NV, Gavrilova SI, Golimbet VE, Voskresenskaia NI, Rogaev EI. [Genetic association between the apolipoprotein E (ApoE) gene alleles and various forms of Alzheimer's disease]. Genetika. 2001 Apr; 37(4):529-35. PMID: 11421127.
      Citations: 5     Fields:    Translation:Humans
    101. Shcherbatykh TV, Kiryanov SA, Korovaitseva GI, Selezneva ND, Voskresenskaya NI, Golimbet VE, Farrer L, Gavrilova SI, Rogaev EI. The angiotensin-converting enzyme gene as a possible risk or protective factor in Alzheimer's disease. Neurosci Behav Physiol. 2001 Mar-Apr; 31(2):179-81. PMID: 11388371.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    102. Lukiw WJ, Gordon WC, Rogaev EI, Thompson H, Bazan NG. Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis. Neuroreport. 2001 Jan 22; 12(1):53-7. PMID: 11201091.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    103. Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature. 2000 Sep 07; 407(6800):48-54. PMID: 10993067.
      Citations: 261     Fields:    Translation:HumansAnimalsCells
    104. Farrer LA, Sherbatich T, Keryanov SA, Korovaitseva GI, Rogaeva EA, Petruk S, Premkumar S, Moliaka Y, Song YQ, Pei Y, Sato C, Selezneva ND, Voskresenskaya S, Golimbet V, Sorbi S, Duara R, Gavrilova S, St George-Hyslop PH, Rogaev EI. Association between angiotensin-converting enzyme and Alzheimer disease. Arch Neurol. 2000 Feb; 57(2):210-4. PMID: 10681079.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    105. Rogaev EI. [Genetic factors and a polygenic model of Alzheimer's disease]. Genetika. 1999 Nov; 35(11):1558-71. PMID: 10624576.
      Citations: 3     Fields:    Translation:Humans
    106. Rogaev EI, Zinchenko RA, Dvoryachikov G, Sherbatich T, Ginter EK. Total hypotrichosis: genetic form of alopecia not linked to hairless gene. Lancet. 1999 Sep 25; 354(9184):1097-8. PMID: 10509509.
      Citations:    Fields:    Translation:Humans
    107. Korovaitseva GI, Premkumar S, Grigorenko A, Molyaka Y, Galimbet V, Selezneva N, Gavrilova SI, Farrer LA, Rogaev EI. Alpha-2 macroglobulin gene in early- and late-onset Alzheimer disease. Neurosci Lett. 1999 Aug 20; 271(2):129-31. PMID: 10477119.
      Citations: 1     Fields:    Translation:Humans
    108. Shcherbatykh TV, Kir'ianov SA, Korova?tsev GI, Selezneva ND, Voskresenskaia NI, Golimbet VE, Farrr L, Gavrilova SI, Rogaev EI. [Angiotensin-converting enzyme gene as a possible risk factor or protective factor in Alzheimer's disease]. Zh Nevrol Psikhiatr Im S S Korsakova. 1999; 99(9):51-2. PMID: 10533256.
      Citations:    Fields:    Translation:Humans
    109. Rogaev EI. [Genetic basis for Alzheimer's disease and other dementias and prospects of molecular diagnosis]. Vestn Ross Akad Med Nauk. 1999; (1):33-9. PMID: 10078061.
      Citations:    Fields:    Translation:HumansAnimals
    110. Solov'ev IV, Iurov IuB, Vorsanova SG, Marcais B, Rogaev EI, Kapanadze BI, Brodianski? VM, Iankovski? NK, Roizes G. [Study of alpha-satellite DNA in cosmid libraries, specific for chromosomes 13, 21, and 22, using fluorescence in situ hybridization]. Genetika. 1998 Nov; 34(11):1470-9. PMID: 10096024.
      Citations: 2     Fields:    Translation:HumansCells
    111. Rogaev EI. [Presenilins: detection and characterization of Alzheimer's disease genes]. Mol Biol (Mosk). 1998 Jan-Feb; 32(1):71-83. PMID: 9566253.
      Citations:    Fields:    Translation:HumansCells
    112. Korovaitseva GI, Bukina A, Farrer LA, Rogaev EI. Presenilin polymorphisms in Alzheimer's disease. Lancet. 1997 Sep 27; 350(9082):959. PMID: 9314893.
      Citations: 2     Fields:    Translation:Humans
    113. Kir'ianov SA, Rogaev EI. [Rapid isolation of CpG-islands by PCR-amplification of genomic DNA fragments using a "CpG-enriched" primer]. Genetika. 1997 Jul; 33(7):891-8. PMID: 9378285.
      Citations:    Fields:    Translation:HumansCells
    114. Rogaev EI, Sherrington R, Wu C, Levesque G, Liang Y, Rogaeva EA, Ikeda M, Holman K, Lin C, Lukiw WJ, de Jong PJ, Fraser PE, Rommens JM, St George-Hyslop P. Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease. Genomics. 1997 Mar 15; 40(3):415-24. PMID: 9073509.
      Citations: 21     Fields:    Translation:HumansCells
    115. Boulianne GL, Livne-Bar I, Humphreys JM, Liang Y, Lin C, Rogaev E, St George-Hyslop P. Cloning and characterization of the Drosophila presenilin homologue. Neuroreport. 1997 Mar 03; 8(4):1025-9. PMID: 9141085.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    116. Rogaev EI, Ovchinnikov IV, Dzhorzh-Khislop P, Rogaeva EA. [Comparison of mitochondrial DNA sequences of T.N. Kulikovski?-Romanov, the nephew of Tsar Nikola? II Romanov, with DNA from the putative remains of the Tsar]. Genetika. 1996 Dec; 32(12):1690-2. PMID: 9102362.
      Citations: 1     Fields:    Translation:Humans
    117. Igarashi S, Takiyama Y, Cancel G, Rogaeva EA, Sasaki H, Wakisaka A, Zhou YX, Takano H, Endo K, Sanpei K, Oyake M, Tanaka H, Stevanin G, Abbas N, Dürr A, Rogaev EI, Sherrington R, Tsuda T, Ikeda M, Cassa E, Nishizawa M, Benomar A, Julien J, Weissenbach J, Wang GX, Agid Y, St George-Hyslop PH, Brice A, Tsuji S. Intergenerational instability of the CAG repeat of the gene for Machado-Joseph disease (MJD1) is affected by the genotype of the normal chromosome: implications for the molecular mechanisms of the instability of the CAG repeat. Hum Mol Genet. 1996 Jul; 5(7):923-32. PMID: 8817326.
      Citations: 12     Fields:    Translation:HumansCells
    118. Sherrington R, Froelich S, Sorbi S, Campion D, Chi H, Rogaeva EA, Levesque G, Rogaev EI, Lin C, Liang Y, Ikeda M, Mar L, Brice A, Agid Y, Percy ME, Clerget-Darpoux F, Piacentini S, Marcon G, Nacmias B, Amaducci L, Frebourg T, Lannfelt L, Rommens JM, St George-Hyslop PH. Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum Mol Genet. 1996 Jul; 5(7):985-8. PMID: 8817335.
      Citations: 76     Fields:    Translation:Humans
    119. Rogaev EI, Rogaeva EA, Korovaitseva GI, Farrer LA, Petrin AN, Keryanov SA, Turaeva S, Chumakov I, St George-Hyslop P, Ginter EK. Linkage of polymorphic congenital cataract to the gamma-crystallin gene locus on human chromosome 2q33-35. Hum Mol Genet. 1996 May; 5(5):699-703. PMID: 8733140.
      Citations: 18     Fields:    Translation:HumansCells
    120. Trower MK, Orton SM, Purvis IJ, Sanseau P, Riley J, Christodoulou C, Burt D, See CG, Elgar G, Sherrington R, Rogaev EI, St George-Hyslop P, Brenner S, Dykes CW. Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24.3) associated with familial Alzheimer disease (AD3 locus) Proc Natl Acad Sci U S A. 1996 Feb 20; 93(4):1366-9. PMID: 8643637.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    121. Golimbet VE, Ovchinnikov IV, Voskresenskaia NI, Iurov IuB, Rogaev EI, Doronina OA, Maksunova IV. [The search for a mutation in the gene coding the beta-amyloid protein precursor gene in patients with Alzheimer-type dementias]. Zh Nevrol Psikhiatr Im S S Korsakova. 1996; 96(1):75-8. PMID: 8677726.
      Citations:    Fields:    Translation:HumansCells
    122. Tsuda T, Chi H, Liang Y, Rogaeva EA, Sherrington R, Levesque G, Ikeda M, Rogaev EI, Pollen D, Freedman M, et al. Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases. Neurosci Lett. 1995 Dec 08; 201(2):188-90. PMID: 8848249.
      Citations: 1     Fields:    Translation:HumansCells
    123. Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature. 1995 Aug 31; 376(6543):775-8. PMID: 7651536.
      Citations: 478     Fields:    Translation:HumansCells
    124. Sorbi S, Nacmias B, Forleo P, Piacentini S, Sherrington R, Rogaev E, St George Hyslop P, Amaducci L. Missense mutation of S182 gene in Italian families with early-onset Alzheimer's disease. Lancet. 1995 Aug 12; 346(8972):439-40. PMID: 7623584.
      Citations: 14     Fields:    Translation:HumansCells
    125. Takiyama Y, Igarashi S, Rogaeva EA, Endo K, Rogaev EI, Tanaka H, Sherrington R, Sanpei K, Liang Y, Saito M, et al. Evidence for inter-generational instability in the CAG repeat in the MJD1 gene and for conserved haplotypes at flanking markers amongst Japanese and Caucasian subjects with Machado-Joseph disease. Hum Mol Genet. 1995 Jul; 4(7):1137-46. PMID: 8528200.
      Citations: 31     Fields:    Translation:HumansCells
    126. Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 1995 Jun 29; 375(6534):754-60. PMID: 7596406.
      Citations: 980     Fields:    Translation:HumansAnimalsCells
    127. Rogaev EI, Rogaeva EA, Dzhordzh-Khislop P. [Direct detection of loci with pathologic trinucleotide repeats in diseases with anticipation]. Genetika. 1995 Apr; 31(4):578-82. PMID: 7607444.
      Citations:    Fields:    Translation:HumansCells
    128. Rogaev EI, Lukiw WJ, Lavrushina O, Rogaeva EA, St George-Hyslop PH. The upstream promoter of the beta-amyloid precursor protein gene (APP) shows differential patterns of methylation in human brain. Genomics. 1994 Jul 15; 22(2):340-7. PMID: 7528717.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    129. St George-Hyslop P, Rogaeva E, Huterer J, Tsuda T, Santos J, Haines JL, Schlumpf K, Rogaev EI, Liang Y, McLachlan DR, et al. Machado-Joseph disease in pedigrees of Azorean descent is linked to chromosome 14. Am J Hum Genet. 1994 Jul; 55(1):120-5. PMID: 8023841.
      Citations: 4     Fields:    Translation:HumansCells
    130. Tsuda T, Lopez R, Rogaeva EA, Freedman M, Rogaev E, Drachman D, Pollen D, Haines J, Liang Y, McLachlan DR, et al. Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium? Ann Neurol. 1994 Jul; 36(1):97-100. PMID: 8024269.
      Citations: 4     Fields:    Translation:Humans
    131. Lukiw WJ, Rogaev EI, Wong L, Vaula G, McLachlan DR, St George Hyslop P. Protein-DNA interactions in the promoter region of the amyloid precursor protein (APP) gene in human neocortex. Brain Res Mol Brain Res. 1994 Mar; 22(1-4):121-31. PMID: 8015372.
      Citations: 15     Fields:    Translation:HumansCells
    132. Rogaev EI, Rogaeva EA, Ginter EK, Korova?tseva GI, Farrer L, Shlenski? AB, Prytkov AN, St George-Hyslop P, Mordovtsev VN. [Mapping the gene for palmoplantar hyperkeratosis (thylosis) to chromosome 17 in the 17q12-q24 region]. Genetika. 1994 Mar; 30(3):326-9. PMID: 7514555.
      Citations:    Fields:    Translation:HumansCells
    133. St George-Hyslop P, McLachlan DC, Tsuda T, Rogaev E, Karlinsky H, Lippa CF, Pollen D, Tuda T. Alzheimer's disease and possible gene interaction. Science. 1994 Jan 28; 263(5146):537. PMID: 8290965.
      Citations: 19     Fields:    Translation:Humans
    134. Rogaev EI, Lukiw WJ, Vaula G, Haines JL, Rogaeva EA, Tsuda T, Alexandrova N, Liang Y, Mortilla M, Amaducci L, Bergamini L, Bruni AC, Foncin JF, Macciardi F, Montesi M, Sorbi S, Rainero I, Pinessi L, Polinsky RJ, Frommelt P, Duara R, Lopez R, Pollen D, Gusella JF, Tanzi R, MacLachlan D, Crapper D, St George-Hyslop PH, et al. Analysis of the c-FOS gene on chromosome 14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's disease. Neurology. 1993 Nov; 43(11):2275-9. PMID: 8232942.
      Citations: 2     Fields:    Translation:HumansCells
    135. Rogaev EI, Rogaeva EA, Ginter EK, Korovaitseva GI, Farrer LA, Shlensky AB, Pritkov AN, Mordovtsev VN, St George-Hyslop PH. Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes. Nat Genet. 1993 Oct; 5(2):158-62. PMID: 7504553.
      Citations: 7     Fields:    Translation:HumansCells
    136. Rogaev EI, Korova?tseva GI, Ginter EK, Prytkov AN, Maksudova KhA. [Mapping of the dominant gene of hyperkeratosis palmaris et plantaris in man]. Genetika. 1993 Jul; 29(7):1180-5. PMID: 8370514.
      Citations:    Fields:    Translation:Humans
    137. Tupler R, Rogaeva E, Vaula G, Mortilla M, Lukiw W, Liang Y, Hancock R, Rogaev E, St George-Hyslop P. A highly informative microsatellite repeat polymorphism in intron 1 of the human amyloid precursor protein (APP) gene. Hum Mol Genet. 1993 May; 2(5):620. PMID: 8518820.
      Citations: 1     Fields:    Translation:HumansCells
    138. Ginter EK, Rogaev EI, Korova?tseva GI, Turaeva ShM, Petrin AN, Spitsyn VA, Tarlycheva LV. [Further analysis of location of the gene for inborn dominant Nochurli cataract]. Genetika. 1993 Apr; 29(4):670-4. PMID: 8354473.
      Citations:    Fields:    Translation:HumansCells
    139. St George-Hyslop P, Haines J, Rogaev E, Mortilla M, Vaula G, Pericak-Vance M, Foncin JF, Montesi M, Bruni A, Sorbi S, Rainero I, Pinessi L, Pollen D, Polinsky R, Nee L, Kennedy J, Macciardi F, Rogaeva E, Liang Y, Alexandrova N, Lukiw W, Schlumpf K, Tanzi R, Tsuda T, Farrer L, Cantu JM, Duara R, Amaducci L, Bergamini L, Gusella J, Roses A, Crapper McLachlan D, et al. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat Genet. 1992 Dec; 2(4):330-4. PMID: 1303289.
      Citations: 93     Fields:    Translation:HumansCells
    140. Rogaev E, Rogaeva E, Lukiw WJ, Vaula G, Liang Y, Hancock R, McLachlan DC, St George-Hyslop PH. An informative microsatellite repeat polymorphism in the human neurofilament light polypeptide (NEFL) gene. Hum Mol Genet. 1992 Dec; 1(9):781. PMID: 1302625.
      Citations: 3     Fields:    Translation:HumansCells
    141. Rogaev EI, Keryanov SA. Unusual variability of the complex dinucleotide repeat block at the SPN locus. Hum Mol Genet. 1992 Nov; 1(8):657. PMID: 1301183.
      Citations: 1     Fields:    Translation:HumansCells
    142. Rogaev EI, Keryanov SA, Malyako YK. Dinucleotide repeat polymorphisms at the P1, HBE1 and MYH7 loci. Hum Mol Genet. 1992 Jul; 1(4):285. PMID: 1363870.
      Citations:    Fields:    Translation:HumansCells
    143. Rogaev EI, Iurov IuB, Iakovlev AG. [Molecular genetics of the human brain]. Vestn Ross Akad Med Nauk. 1992; (8):11-6. PMID: 1282409.
      Citations:    Fields:    Translation:HumansCells
    144. Ginter EK, Petrin AN, Spitsyn VA, Rogaev EI. [An attempt to locate the gene for congenital cataracts using linkage analysis]. Genetika. 1991 Oct; 27(10):1840-9. PMID: 1778455.
      Citations: 1     Fields:    Translation:Humans
    145. Rogaev EI, Shlenskii AB. Individual-specific patterns of human variable genomic regions detected by a DNA probe from the HIV-1 env gene. Biomed Sci. 1991; 2(3):311-3. PMID: 1751767.
      Citations:    Fields:    Translation:HumansCells
    146. Rogaev EI, Iurov IuB. [Interindividual hyperpolymorphism of autosomal satellites III of human DNA]. Genetika. 1990 Aug; 26(8):1532-5. PMID: 1979546.
      Citations: 1     Fields:    Translation:HumansCells
    147. Rogaev EI. Simple human DNA-repeats associated with genomic hypervariability, flanking the genomic retroposons and similar to retroviral sites. Nucleic Acids Res. 1990 Apr 11; 18(7):1879-85. PMID: 2159624.
      Citations: 3     Fields:    Translation:HumansCells
    148. Rogaev EI, Shlensky AB. The genomic DNA phi Fd103 probe is sensitive marker for detection of human hypervariable genomic regions. Nucleic Acids Res. 1990 Feb 25; 18(4):1081. PMID: 2179868.
      Citations:    Fields:    Translation:HumansCells
    149. Rogaev EI, Vetchinkina AA, Iurov IuB. Species specific variant of human centromeric DNA repeats: localization on chromosome 18 and recent amplification in human ancestral line. Mol Gen Mikrobiol Virusol. 1989 Apr; (4):10-4. PMID: 2747696.
      Citations:    Fields:    Translation:HumansAnimalsCells
    150. Rogaev EI. Two novel human DNA tandem repeat families from the hypervariable DNA probe homologous to human apolipoprotein CII-gene intron and D. virilis satellite. Nucleic Acids Res. 1989 Feb 11; 17(3):1246. PMID: 2922263.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    151. Rogaev EI, Shapiro IuA. [High interindividual polymorphism in restriction fragment length and copy number of the TURI family of moderate human DNA repetitions]. Biull Eksp Biol Med. 1987 Jan; 103(1):57-8. PMID: 2879576.
      Citations: 2     Fields:    Translation:HumansCells
    152. Za?tsev IZ, Rogaev EI. [Structural analysis of alphoid DNA of primates. I. Heterogeneity of nucleotide sequence of alphoid repeats in human DNA]. Mol Biol (Mosk). 1986 May-Jun; 20(3):663-73. PMID: 3014312.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
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