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Darryl Conte PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentRNA Therapeutics Institute
AddressUMass Chan Medical School
373 Plantation Street
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program


    Collapse Biography 
    Collapse education and training
    Rensselaer Polytechnic Institute, Troy, NY, United StatesBSMathematics
    State University of New York, Albany, Albany, NY, United StatesPHDBiomedical Sciences

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kim H, Ding YH, Zhang G, Yan YH, Conte D, Dong MQ, Mello CC. HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans. Elife. 2021 05 18; 10. PMID: 34003109.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Kim H, Ding YH, Lu S, Zuo MQ, Tan W, Conte D, Dong MQ, Mello CC. PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans. Elife. 2021 05 18; 10. PMID: 34003111.
      Citations:    Fields:    Translation:AnimalsCells
    3. Chaves DA, Dai H, Li L, Moresco JJ, Oh ME, Conte D, Yates JR, Mello CC, Gu W. The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans. Mol Cell. 2021 02 04; 81(3):546-557.e5. PMID: 33378643.
      Citations: 6     Fields:    Translation:AnimalsCells
    4. Song CQ, Li Y, Mou H, Moore J, Park A, Pomyen Y, Hough S, Kennedy Z, Fischer A, Yin H, Anderson DG, Conte D, Zender L, Wang XW, Thorgeirsson S, Weng Z, Xue W. Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice. Gastroenterology. 2017 04; 152(5):1161-1173.e1. PMID: 27956228.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    5. Tsai HY, Chen CC, Conte D, Moresco JJ, Chaves DA, Mitani S, Yates JR, Tsai MD, Mello CC. A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi. Cell. 2015 Jan 29; 160(3):407-19. PMID: 25635455.
      Citations: 36     Fields:    Translation:AnimalsCells
    6. Conte D, MacNeil LT, Walhout AJM, Mello CC. RNA Interference in Caenorhabditis elegans. Curr Protoc Mol Biol. 2015 Jan 05; 109:26.3.1-26.3.30. PMID: 25559107.
      Citations: 29     Fields:    Translation:Animals
    7. Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JH, Conte D, Gundersen-Rindal DE, Marshall WL, Yates JR, Silverman N, Mello CC. A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection. Elife. 2014 Jun 25; 3. PMID: 24966209.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    8. Kim H, Ishidate T, Ghanta KS, Seth M, Conte D, Shirayama M, Mello CC. A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans. Genetics. 2014 Aug; 197(4):1069-80. PMID: 24879462.
      Citations: 138     Fields:    Translation:AnimalsCells
    9. Bansal A, Kwon ES, Conte D, Liu H, Gilchrist MJ, MacNeil LT, Tissenbaum HA. Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan. Longev Healthspan. 2014; 3:5. PMID: 24834345.
      Citations:    
    10. Forloni M, Dogra SK, Dong Y, Conte D, Ou J, Zhu LJ, Deng A, Mahalingam M, Green MR, Wajapeyee N. miR-146a promotes the initiation and progression of melanoma by activating Notch signaling. Elife. 2014 Feb 18; 3:e01460. PMID: 24550252.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    11. Seth M, Shirayama M, Gu W, Ishidate T, Conte D, Mello CC. The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression. Dev Cell. 2013 Dec 23; 27(6):656-63. PMID: 24360782.
      Citations: 103     Fields:    Translation:AnimalsCells
    12. Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D, Yates JR, Mello CC. Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans. Cell. 2013 Dec 19; 155(7):1532-44. PMID: 24360276.
      Citations: 83     Fields:    Translation:AnimalsCells
    13. Kim S, Ishidate T, Sharma R, Soto MC, Conte D, Mello CC, Shirayama M. Wnt and CDK-1 regulate cortical release of WRM-1/?-catenin to control cell division orientation in early Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):E918-27. PMID: 23431196.
      Citations: 16     Fields:    Translation:AnimalsCells
    14. Gu W, Lee HC, Chaves D, Youngman EM, Pazour GJ, Conte D, Mello CC. CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors. Cell. 2012 Dec 21; 151(7):1488-500. PMID: 23260138.
      Citations: 114     Fields:    Translation:AnimalsCells
    15. Shirayama M, Seth M, Lee HC, Gu W, Ishidate T, Conte D, Mello CC. piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline. Cell. 2012 Jul 06; 150(1):65-77. PMID: 22738726.
      Citations: 281     Fields:    Translation:AnimalsCells
    16. Lee HC, Gu W, Shirayama M, Youngman E, Conte D, Mello CC. C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts. Cell. 2012 Jul 06; 150(1):78-87. PMID: 22738724.
      Citations: 182     Fields:    Translation:AnimalsCells
    17. Thivierge C, Makil N, Flamand M, Vasale JJ, Mello CC, Wohlschlegel J, Conte D, Duchaine TF. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Nat Struct Mol Biol. 2011 Dec 18; 19(1):90-7. PMID: 22179787.
      Citations: 29     Fields:    Translation:AnimalsCells
    18. Gu W, Claycomb JM, Batista PJ, Mello CC, Conte D. Cloning Argonaute-associated small RNAs from Caenorhabditis elegans. Methods Mol Biol. 2011; 725:251-80. PMID: 21528459.
      Citations: 12     Fields:    Translation:Animals
    19. Conte D, Mello CC. Primal RNAs: The end of the beginning? Cell. 2010 Feb 19; 140(4):452-4. PMID: 20178736.
      Citations: 2     Fields:    Translation:AnimalsCells
    20. Vasale JJ, Gu W, Thivierge C, Batista PJ, Claycomb JM, Youngman EM, Duchaine TF, Mello CC, Conte D. Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3582-7. PMID: 20133583.
      Citations: 105     Fields:    Translation:AnimalsCells
    21. Claycomb JM, Batista PJ, Pang KM, Gu W, Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, Conte D, Mello CC. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell. 2009 Oct 02; 139(1):123-34. PMID: 19804758.
      Citations: 223     Fields:    Translation:Animals
    22. Gu W, Shirayama M, Conte D, Vasale J, Batista PJ, Claycomb JM, Moresco JJ, Youngman EM, Keys J, Stoltz MJ, Chen CC, Chaves DA, Duan S, Kasschau KD, Fahlgren N, Yates JR, Mitani S, Carrington JC, Mello CC. Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell. 2009 Oct 23; 36(2):231-44. PMID: 19800275.
      Citations: 261     Fields:    Translation:AnimalsCells
    23. Batista PJ, Ruby JG, Claycomb JM, Chiang R, Fahlgren N, Kasschau KD, Chaves DA, Gu W, Vasale JJ, Duan S, Conte D, Luo S, Schroth GP, Carrington JC, Bartel DP, Mello CC. PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. Mol Cell. 2008 Jul 11; 31(1):67-78. PMID: 18571452.
      Citations: 294     Fields:    Translation:AnimalsCells
    24. Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 2006 Jan 27; 124(2):343-54. PMID: 16439208.
      Citations: 212     Fields:    Translation:AnimalsCells
    25. Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 2005 Jul 28; 436(7050):593-7. PMID: 16049496.
      Citations: 141     Fields:    Translation:AnimalsCells
    26. Mello CC, Conte D. Revealing the world of RNA interference. Nature. 2004 Sep 16; 431(7006):338-42. PMID: 15372040.
      Citations: 294     Fields:    Translation:AnimalsCells
    27. Conte D, Mello CC. RNA interference in Caenorhabditis elegans. Curr Protoc Mol Biol. 2003 May; Chapter 26:Unit 26.3. PMID: 18265327.
      Citations: 5     Fields:    Translation:AnimalsCells
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