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Babs R Soller PhD

TitleProfessor Emeritus
InstitutionUniversity of Massachusetts Medical School
DepartmentAnesthesiology and Perioperative Medicine
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-5904
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentAnesthesiology and Perioperative Medicine

    InstitutionUMMS - School of Medicine
    DepartmentSurgery
    DivisionCardiothoracic Surgery

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology


    Collapse Biography 
    Collapse education and training
    Union College, Barbourville, KY, United StatesBSChemistry
    Princeton University, Princeton, NJ, United StatesMAChemistry
    Princeton University, Princeton, NJ, United StatesPHDChemistry

    Collapse Overview 
    Collapse overview

    Academic Background

    Ph.D. (Physical Chemistry), Princeton

    Photo: Babs Soller, Ph.D.

    We are exploring the application of optical spectroscopy for the noninvasive measurement of blood and tissue chemistry, ultimately to be able to perform chemical analysis and diagnosis without removing a sample from the patient. We are currently investigating the use of near infrared spectroscopy in combination with in-vivo chemometric techniques to determine tissue pH, tissue oxygen tension and blood hematocrit. We are also interested in the application of this technology in the triage and treatment of trauma patients.



    Collapse Rotation Projects




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Sprick JD, Soller BR, Rickards CA. The efficacy of novel anatomical sites for the assessment of muscle oxygenation during central hypovolemia. Exp Biol Med (Maywood). 2016 Nov; 241(17):2007-2013. PMID: 27439541.
      View in: PubMed
    2. Welch J, Kanter B, Skora B, McCombie S, Henry I, McCombie D, Kennedy R, Soller B. Multi-parameter vital sign database to assist in alarm optimization for general care units. J Clin Monit Comput. 2016 Dec; 30(6):895-900. PMID: 26439830.
      View in: PubMed
    3. Soller B, Zou F, Prince MD, Dubick MA, Sondeen JL. Comparison of Noninvasive pH and Blood Lactate as Predictors of Mortality in a Swine Hemorrhagic Shock with Restricted Volume Resuscitation Model. Shock. 2015 Aug; 44 Suppl 1:90-5. PMID: 25526374.
      View in: PubMed
    4. Soller B, Srikiatkachorn A, Zou F, Rothman AL, Yoon IK, Gibbons RV, Kalayanarooj S, Thomas SJ, Green S. Preliminary evaluation of near infrared spectroscopy as a method to detect plasma leakage in children with dengue hemorrhagic fever. BMC Infect Dis. 2014 Jul 17; 14:396. PMID: 25033831.
      View in: PubMed
    5. Schlader ZJ, Rivas E, Soller BR, Convertino VA, Crandall CG. Tissue oxygen saturation during hyperthermic progressive central hypovolemia. Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15; 307(6):R731-6. PMID: 25031230.
      View in: PubMed
    6. Soller B, Smith C, Zou F, Ellerby GE, Prince MD, Sondeen JL. Investigation of noninvasive muscle pH and oxygen saturation during uncontrolled hemorrhage and resuscitation in swine. Shock. 2014 Jul; 42(1):44-51. PMID: 24667624.
      View in: PubMed
    7. Soller BR, Zou F, Ryan KL, Rickards CA, Ward K, Convertino VA. Lightweight noninvasive trauma monitor for early indication of central hypovolemia and tissue acidosis: a review. J Trauma Acute Care Surg. 2012 Aug; 73(2 Suppl 1):S106-11. PMID: 22847078.
      View in: PubMed
    8. Lee SM, Clarke MS, O'Connor DP, Stroud L, Ellerby GE, Soller BR. Near infrared spectroscopy-derived interstitial hydrogen ion concentration and tissue oxygen saturation during ambulation. Eur J Appl Physiol. 2011 Aug; 111(8):1705-14. PMID: 21212975.
      View in: PubMed
    9. Zou F, Jin C, Ross RR, Soller B. Investigation of spectral interferences on the accuracy of broadband CW-NIRS tissue SO(2) determination. Biomed Opt Express. 2010 Aug 30; 1(3):748-761. PMID: 21258506.
      View in: PubMed
    10. Ward KR, Tiba MH, Ryan KL, Filho IP, Rickards CA, Witten T, Soller BR, Ludwig DA, Convertino VA. Oxygen transport characterization of a human model of progressive hemorrhage. Resuscitation. 2010 Aug; 81(8):987-93. PMID: 20418009.
      View in: PubMed
    11. Soller BR, Yang Y, Soyemi OO, Heard SO, Ryan KL, Rickards CA, Convertino VA, Cooke WH, Crookes BA. Near infrared spectroscopy. Crit Care Med. 2009 Jan; 37(1):385. PMID: 19318822.
      View in: PubMed
    12. Soller BR, Ryan KL, Rickards CA, Cooke WH, Yang Y, Soyemi OO, Crookes BA, Heard SO, Convertino VA. Oxygen saturation determined from deep muscle, not thenar tissue, is an early indicator of central hypovolemia in humans. Crit Care Med. 2008 Jan; 36(1):176-82. PMID: 18090350.
      View in: PubMed
    13. Soller BR, Yang Y, Lee SM, Wilson C, Hagan RD. Noninvasive determination of exercise-induced hydrodgen ion threshold through direct optical measurement. J Appl Physiol (1985). 2008 Mar; 104(3):837-44. PMID: 18096753.
      View in: PubMed
    14. Soller BR, Yang Y, Soyemi OO, Ryan KL, Rickards CA, Walz JM, Heard SO, Convertino VA. Noninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans. J Appl Physiol (1985). 2008 Feb; 104(2):475-81. PMID: 18006869.
      View in: PubMed
    15. Yang Y, Soyemi O, Scott PJ, Landry MR, Lee SM, Stroud L, Soller BR. Quantitative measurement of muscle oxygen saturation without influence from skin and fat using continuous-wave near infrared spectroscopy. Opt Express. 2007 Oct 17; 15(21):13715-30. PMID: 19550643.
      View in: PubMed
    16. Soller BR, Hagan RD, Shear M, Walz JM, Landry M, Anunciacion D, Orquiola A, Heard SO. Comparison of intramuscular and venous blood pH, PCO(2) and PO(2) during rhythmic handgrip exercise. Physiol Meas. 2007 Jun; 28(6):639-49. PMID: 17664618.
      View in: PubMed
    17. Yang Y, Soyemi OO, Landry MR, Soller BR. Noninvasive in vivo measurement of venous blood pH during exercise using near-infrared reflectance spectroscopy. Appl Spectrosc. 2007 Feb; 61(2):223-9. PMID: 17331316.
      View in: PubMed
    18. Yang Y, Shoer L, Soyemi OO, Landry MR, Soller BR. Removal of analyte-irrelevant variations in near-infrared tissue spectra. Appl Spectrosc. 2006 Sep; 60(9):1070-7. PMID: 17002833.
      View in: PubMed
    19. Yang Y, Landry MR, Soyemi OO, Shear MA, Anunciacion DS, Soller BR. Simultaneous correction of the influence of skin color and fat on tissue spectroscopy by use of a two-distance fiber-optic probe and orthogonalization technique. Opt Lett. 2005 Sep 1; 30(17):2269-71. PMID: 16190440.
      View in: PubMed
    20. Yang Y, Soyemi OO, Landry MR, Soller BR. Influence of a fat layer on the near infrared spectra of human muscle: quantitative analysis based on two-layered Monte Carlo simulations and phantom experiments. Opt Express. 2005 Mar 7; 13(5):1570-9. PMID: 16044624.
      View in: PubMed
    21. Soyemi OO, Landry MR, Yang Y, Idwasi PO, Soller BR. Skin color correction for tissue spectroscopy: demonstration of a novel approach with tissue-mimicking phantoms. Appl Spectrosc. 2005 Feb; 59(2):237-44. PMID: 15720765.
      View in: PubMed
    22. Khan T, Soller B, Naghavi M, Casscells W. Tissue pH determination for the detection of metabolically active, inflamed vulnerable plaques using near-infrared spectroscopy: an in-vitro feasibility study. Cardiology. 2005; 103(1):10-6. PMID: 15528895.
      View in: PubMed
    23. Soller BR, Hsi C, Favreau J, Cingo N, Lancey RA, Okike ON, Vander Salm TJ. Multiparameter fiber optic sensor for the assessment of intramyocardial perfusion. J Card Surg. 2004 Mar-Apr; 19(2):167-74. PMID: 15016060.
      View in: PubMed
    24. Soller BR, Khan T, Favreau J, Hsi C, Puyana JC, Heard SO. Investigation of muscle pH as an indicator of liver pH and injury from hemorrhagic shock. J Surg Res. 2003 Oct; 114(2):195-201. PMID: 14559446.
      View in: PubMed
    25. Soller BR, Idwasi PO, Balaguer J, Levin S, Simsir SA, Vander Salm TJ, Collette H, Heard SO. Noninvasive, near infrared spectroscopic-measured muscle pH and PO2 indicate tissue perfusion for cardiac surgical patients undergoing cardiopulmonary bypass. Crit Care Med. 2003 Sep; 31(9):2324-31. PMID: 14501963.
      View in: PubMed
    26. Soller BR, Favreau J, Idwasi PO. Investigation of electrolyte measurement in diluted whole blood using spectroscopic and chemometric methods. Appl Spectrosc. 2003 Feb; 57(2):146-51. PMID: 14610950.
      View in: PubMed
    27. Hsi C, Cuenoud H, Soller BR, Kim H, Favreau J, Vander Salm TJ, Moran JM. Experimental coronary artery occlusion: relevance to off-pump cardiac surgery. Asian Cardiovasc Thorac Ann. 2002 Dec; 10(4):293-7. PMID: 12538270.
      View in: PubMed
    28. Soller BR, Cabrera M, Smith SM, Sutton JP. Smart medical systems with application to nutrition and fitness in space. Nutrition. 2002 Oct; 18(10):930-6. PMID: 12361790.
      View in: PubMed
    29. Naghavi M, John R, Naguib S, Siadaty MS, Grasu R, Kurian KC, van Winkle WB, Soller B, Litovsky S, Madjid M, Willerson JT, Casscells W. pH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque. Atherosclerosis. 2002 Sep; 164(1):27-35. PMID: 12119190.
      View in: PubMed
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