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Neil Aronin MD

Endowed TitleHiggins Family Professor in Neuroscience
InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
364 Plantation Street LRB-225
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionEndocrinology & Diabetes

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DivisionCellular Biology & Imaging

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    Collapse Biography 
    Collapse education and training
    Duke University, Durham, NC, United StatesBAHistory
    University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United StatesMD

    Collapse Overview 
    Collapse overview


    • Undergraduate: Duke University, 1966-1970
    • Medical School: University of Pennsylvania, 1970-1974
    • Internship and Residency: Duke University Medical Center, 1974-1977
    • Research Fellowship: Massachusetts General Hospital and Harvard MedicalSchool, 1979-1981


    • University of Massachusetts Medical School, 1981 - present,
    • Professor of Medicine and Cell Biology,
    • Director of Endocrinology and Metabolism

    Board Certifications

    • Internal Medicine, Endocrinology and Metabolism

    Huntington's Disease

    Photo: Neil AroninMy clinical interests focus on neuroendocrinology (pituitary and hypothalamic diseases), inherited endocrine diseases, and adrenal problems. We are currently conducting research in the treatment of patients with impaired pituitary function. My basic research centers on the pathogensis of neurodegenerative diseases, especially Parkinson's disease and Huntington's disease.

    Dr. Aronin's Clinical Site This link goes 
to an external web site

    Collapse Rotation Projects

    Potential Rotation Projects

    Project #1: Molecular Mechanisms in the Pathogenesis of Neurodegenerative Disease. The student can select projects emphasizing either molecular mechanisms of huntingtin in trafficking in neurons or receptor stimulated effects on gene expression in neurons. Techniques include:

    1. Generation of fusion proteins, raising antisera
    2. Preparation of organelles
    3. Immunocytochemistry, light microscopy and electron microscopy
    4. Immunoprecipitation methods
    5. PCR
    6. Protein separation techniques, gel electrophoresis, immunoblotting
    7. Autoradiography

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Belgrad J, Tang Q, Hildebrand S, Summers A, Sapp E, Echeverria D, O'Reilly D, Luu E, Bramato B, Allen S, Cooper D, Alterman J, Yamada K, Aronin N, DiFiglia M, Khvorova A. A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic Acids Res. 2024 Jun 24; 52(11):6099-6113. PMID: 38726879.
    2. Miller R, Paquette J, Barker A, Sapp E, McHugh N, Bramato B, Yamada N, Alterman J, Echeveria D, Yamada K, Watts J, Anaclet C, DiFiglia M, Khvorova A, Aronin N. Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation. bioRxiv. 2024 Jun 08. PMID: 38895198.
    3. Allen S, O'Reilly D, Miller R, Sapp E, Summers A, Paquette J, Moreno DE, Bramato B, McHugh N, Yamada K, Aronin N, DiFiglia M, Khvorova A. mRNA nuclear clustering leads to a difference in mutant huntingtin mRNA and protein silencing by siRNAs in vivo. bioRxiv. 2024 Apr 28. PMID: 38774633.
    4. Deehan MA, Kothuis JM, Sapp E, Chase K, Ke Y, Seeley C, Iuliano M, Kim E, Kennington L, Miller R, Boudi A, Shing K, Li X, Pfister E, Anaclet C, Brodsky M, Kegel-Gleason K, Aronin N, DiFiglia M. Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction. J Neurosci. 2024 Apr 03; 44(14). PMID: 38388424.
    5. Belgrad J, Tang Q, Hildebrand S, Summers A, Sapp E, Echeverria D, O'Reilly D, Luu E, Bramato B, Allen S, Cooper D, Alterman J, Yamada K, Aronin N, DiFiglia M, Khvorova A. A programmable dual-targeting di-valent siRNA scaffold supports potent multi-gene modulation in the central nervous system. bioRxiv. 2023 Dec 19. PMID: 38187561.
    6. Benatti HR, Prestigiacomo RD, Taghian T, Miller R, King R, Gounis MJ, Celik U, Bertrand S, Tuominen S, Bierfeldt L, Parsley E, Gallagher J, Hall EF, McElroy AW, Sena-Esteves M, Khvorova A, Aronin N, Gray-Edwards HL. Awake intracerebroventricular delivery and safety assessment of oligonucleotides in a large animal model. Mol Ther Methods Clin Dev. 2023 Dec 14; 31:101122. PMID: 37920238.
    7. O'Reilly D, Belgrad J, Ferguson C, Summers A, Sapp E, McHugh C, Mathews E, Boudi A, Buchwald J, Ly S, Moreno D, Furgal R, Luu E, Kennedy Z, Hariharan V, Monopoli K, Yang XW, Carroll J, DiFiglia M, Aronin N, Khvorova A. Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease. Mol Ther. 2023 Nov 01; 31(11):3355-3356. PMID: 37751745.
      Citations: 1     Fields:    
    8. Hariharan VN, Caiazzi J, Miller R, Ferguson C, Sapp E, Fakih H, Tang Q, Yamada N, Furgal R, Paquette J, Bramato B, McHugh N, Summers A, Lochmann C, Godinho B, Hildebrand S, Echeverria D, Hassler M, Alterman J, DiFiglia M, Aronin N, Khvorova A, Yamada K. Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo. Res Sq. 2023 Jun 01. PMID: 37398145.
    9. Yamada K, Hariharan VN, Caiazzi J, Miller R, Furguson C, Sapp E, Fakih H, Tan Q, Yamada N, Furgal RC, Paquette J, Bramato B, McHugh N, Summers A, Lochmann C, Godinho BMDC, Hildebrand S, Echeverria D, Hassler MR, Alterman JF, DiFiglia M, Aronin N, Khvorova A. Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo. bioRxiv. 2023 May 26. PMID: 37292886.
    10. O'Reilly D, Belgrad J, Ferguson C, Summers A, Sapp E, McHugh C, Mathews E, Boudi A, Buchwald J, Ly S, Moreno D, Furgal R, Luu E, Kennedy Z, Hariharan V, Monopoli K, Yang XW, Carroll J, DiFiglia M, Aronin N, Khvorova A. Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease. Mol Ther. 2023 06 07; 31(6):1661-1674. PMID: 37177784.
      Citations: 4     Fields:    Translation:AnimalsCells
    11. Ly S, Didiot MC, Ferguson CM, Coles AH, Miller R, Chase K, Echeverria D, Wang F, Sadri-Vakili G, Aronin N, Khvorova A. Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains. Brain Commun. 2022; 4(6):fcac248. PMID: 36458209.
    12. Conroy F, Miller R, Alterman JF, Hassler MR, Echeverria D, Godinho BMDC, Knox EG, Sapp E, Sousa J, Yamada K, Mahmood F, Boudi A, Kegel-Gleason K, DiFiglia M, Aronin N, Khvorova A, Pfister EL. Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models. Nat Commun. 2022 10 03; 13(1):5802. PMID: 36192390.
      Citations: 3     Fields:    Translation:Animals
    13. Estrada-Zuniga CM, Cheng ZM, Ethiraj P, Guo Q, Gonzalez-Cant? H, Adderley E, Lopez H, Landry BN, Zainal A, Aronin N, Ding Y, Wang X, Aguiar RCT, Dahia PLM. A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions. Cell Rep Med. 2022 07 19; 3(7):100686. PMID: 35858593.
      Citations: 3     Fields:    Translation:Humans
    14. Aronin N. Perspective: Tominersen Testing Finds a Way Forward. J Huntingtons Dis. 2022; 11(2):119-120. PMID: 35599494.
      Citations:    Fields:    Translation:HumansPHPublic Health
    15. Oikemus SR, Pfister EL, Sapp E, Chase KO, Kennington LA, Hudgens E, Miller R, Zhu LJ, Chaudhary A, Mick EO, Sena-Esteves M, Wolfe SA, DiFiglia M, Aronin N, Brodsky MH. Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities. Hum Gene Ther. 2022 01; 33(1-2):25-36. PMID: 34376056.
      Citations: 5     Fields:    Translation:Animals
    16. Ferguson CM, Godinho BM, Alterman JF, Coles AH, Hassler M, Echeverria D, Gilbert JW, Knox EG, Caiazzi J, Haraszti RA, King RM, Taghian T, Puri A, Moser RP, Gounis MJ, Aronin N, Gray-Edwards H, Khvorova A. Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep. JCI Insight. 2021 12 22; 6(24). PMID: 34935646.
      Citations: 3     Fields:    Translation:Animals
    17. Yamada K, Hildebrand S, Davis SM, Miller R, Conroy F, Sapp E, Caiazzi J, Alterman JF, Roux L, Echeverria D, Hassler MR, Pfister EL, DiFiglia M, Aronin N, Khvorova A. Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity. Nucleic Acids Res. 2021 12 02; 49(21):12069-12088. PMID: 34850120.
      Citations: 2     Fields:    Translation:Humans
    18. Armaiz-Pena G, Flores SK, Cheng ZM, Zhang X, Esquivel E, Poullard N, Vaidyanathan A, Liu Q, Michalek J, Santillan-Gomez AA, Liss M, Ahmadi S, Katselnik D, Maldonado E, Salgado SA, Jimenez C, Fishbein L, Hamidi O, Else T, Lechan R, Tischler AS, Benn DE, Dwight T, Clifton-Bligh R, Sanso G, Barontini M, Vincent D, Aronin N, Biondi B, Koops M, Bowhay-Carnes E, Gimenez-Roqueplo AP, Alvarez-Eslava A, Bruder JM, Kitano M, Burnichon N, Ding Y, Dahia PLM. Genotype-Phenotype Features of Germline Variants of the TMEM127 Pheochromocytoma Susceptibility Gene: A 10-Year Update. J Clin Endocrinol Metab. 2021 01 01; 106(1):e350-e364. PMID: 33051659.
      Citations: 4     Fields:    Translation:Humans
    19. Pfister EL, Aronin N. Huntington's Disease: Les Jeux Sont Faits? Trends Mol Med. 2020 10; 26(10):889-890. PMID: 32893090.
      Citations: 1     Fields:    Translation:HumansAnimals
    20. Howland D, Ellederova Z, Aronin N, Fernau D, Gallagher J, Taylor A, Hennebold J, Weiss AR, Gray-Edwards H, McBride J. Large Animal Models of Huntington's Disease: What We Have Learned and Where We Need to Go Next. J Huntingtons Dis. 2020; 9(3):201-216. PMID: 32925082.
      Citations: 12     Fields:    Translation:Animals
    21. Batista AR, King OD, Reardon CP, Davis C, Philip V, Gray-Edwards H, Aronin N, Lutz C, Landers J, Sena-Esteves M. Ly6a Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B. Hum Gene Ther. 2020 01; 31(1-2):90-102. PMID: 31696742.
      Citations: 39     Fields:    Translation:AnimalsCells
    22. Taghian T, Marosfoi MG, Puri AS, Cataltepe OI, King RM, Diffie EB, Maguire AS, Martin DR, Fernau D, Batista AR, Kuchel T, Christou C, Perumal R, Chandra S, Gamlin PD, Bertrand SG, Flotte TR, McKenna-Yasek D, Tai PWL, Aronin N, Gounis MJ, Sena-Esteves M, Gray-Edwards HL. A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna. Mol Ther. 2020 02 05; 28(2):411-421. PMID: 31813800.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    23. Alterman JF, Godinho BMDC, Hassler MR, Ferguson CM, Echeverria D, Sapp E, Haraszti RA, Coles AH, Conroy F, Miller R, Roux L, Yan P, Knox EG, Turanov AA, King RM, Gernoux G, Mueller C, Gray-Edwards HL, Moser RP, Bishop NC, Jaber SM, Gounis MJ, Sena-Esteves M, Pai AA, DiFiglia M, Aronin N, Khvorova A. A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system. Nat Biotechnol. 2019 08; 37(8):884-894. PMID: 31375812.
      Citations: 69     Fields:    Translation:Animals
    24. Haraszti RA, Miller R, Dubuke ML, Rockwell HE, Coles AH, Sapp E, Didiot MC, Echeverria D, Stoppato M, Sere YY, Leszyk J, Alterman JF, Godinho BMDC, Hassler MR, McDaniel J, Narain NR, Wollacott R, Wang Y, Shaffer SA, Kiebish MA, DiFiglia M, Aronin N, Khvorova A. Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition. iScience. 2019 Jun 28; 16:230-241. PMID: 31195240.
    25. Tousley A, Iuliano M, Weisman E, Sapp E, Richardson H, Vodicka P, Alexander J, Aronin N, DiFiglia M, Kegel-Gleason KB. Huntingtin associates with the actin cytoskeleton and a-actinin isoforms to influence stimulus dependent morphology changes. PLoS One. 2019; 14(2):e0212337. PMID: 30768638.
      Citations: 16     Fields:    Translation:HumansCells
    26. Tousley A, Iuliano M, Weisman E, Sapp E, Zhang N, Vodicka P, Alexander J, Aviolat H, Gatune L, Reeves P, Li X, Khvorova A, Ellerby LM, Aronin N, DiFiglia M, Kegel-Gleason KB. Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease. J Huntingtons Dis. 2019; 8(1):53-69. PMID: 30594931.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    27. Siddiqui UM, Ayyoub S, Raja S, Yeasmin S, Harlan DM, Aronin N, Torres MS. IMPROVING AFTER-HOURS CALLS TO ENDOCRINOLOGY FELLOWS. Endocr Pract. 2019 Jan; 25(1):51-54. PMID: 30383491.
      Citations:    Fields:    Translation:Humans
    28. Wang D, Zhong L, Li M, Li J, Tran K, Ren L, He R, Xie J, Moser RP, Fraser C, Kuchel T, Sena-Esteves M, Flotte TR, Aronin N, Gao G. Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer. Mol Ther Methods Clin Dev. 2018 Dec 14; 11:65-72. PMID: 30397628.
    29. Haraszti RA, Miller R, Stoppato M, Sere YY, Coles A, Didiot MC, Wollacott R, Sapp E, Dubuke ML, Li X, Shaffer SA, DiFiglia M, Wang Y, Aronin N, Khvorova A. Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity. Mol Ther. 2018 12 05; 26(12):2838-2847. PMID: 30341012.
      Citations: 161     Fields:    Translation:AnimalsCells
    30. Didiot MC, Ferguson CM, Ly S, Coles AH, Smith AO, Bicknell AA, Hall LM, Sapp E, Echeverria D, Pai AA, DiFiglia M, Moore MJ, Hayward LJ, Aronin N, Khvorova A. Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin. Cell Rep. 2018 09 04; 24(10):2553-2560.e5. PMID: 30184490.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    31. Godinho BMDC, Henninger N, Bouley J, Alterman JF, Haraszti RA, Gilbert JW, Sapp E, Coles AH, Biscans A, Nikan M, Echeverria D, DiFiglia M, Aronin N, Khvorova A. Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier. Mol Ther. 2018 11 07; 26(11):2580-2591. PMID: 30143435.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    32. Haraszti RA, Miller R, Didiot MC, Biscans A, Alterman JF, Hassler MR, Roux L, Echeverria D, Sapp E, DiFiglia M, Aronin N, Khvorova A. Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles. Mol Ther. 2018 08 01; 26(8):1973-1982. PMID: 29937418.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    33. Biscans A, Haraszti RA, Echeverria D, Miller R, Didiot MC, Nikan M, Roux L, Aronin N, Khvorova A. Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles. Mol Ther. 2018 06 06; 26(6):1520-1528. PMID: 29699940.
      Citations: 14     Fields:    Translation:HumansCells
    34. Hassler MR, Turanov AA, Alterman JF, Haraszti RA, Coles AH, Osborn MF, Echeverria D, Nikan M, Salomon WE, Roux L, Godinho BMDC, Davis SM, Morrissey DV, Zamore PD, Karumanchi SA, Moore MJ, Aronin N, Khvorova A. Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo. Nucleic Acids Res. 2018 03 16; 46(5):2185-2196. PMID: 29432571.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    35. Pfister EL, DiNardo N, Mondo E, Borel F, Conroy F, Fraser C, Gernoux G, Han X, Hu D, Johnson E, Kennington L, Liu P, Reid SJ, Sapp E, Vodicka P, Kuchel T, Morton AJ, Howland D, Moser R, Sena-Esteves M, Gao G, Mueller C, DiFiglia M, Aronin N. Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease. Hum Gene Ther. 2018 06; 29(6):663-673. PMID: 29207890.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    36. Didiot MC, Haraszti RA, Aronin N, Khvorova A. Loading of Extracellular Vesicles with Hydrophobically Modified siRNAs. Methods Mol Biol. 2018; 1740:199-214. PMID: 29388146.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    37. Romo L, Mohn ES, Aronin N. A Fresh Look at Huntingtin mRNA Processing in Huntington's Disease. J Huntingtons Dis. 2018; 7(2):101-108. PMID: 29865084.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    38. Mondo E, Moser R, Gao G, Mueller C, Sena-Esteves M, Sapp E, Pfister E, O'Connell D, Takle K, Erger KE, Liu W, Conlon TJ, DiFiglia M, Gounis MJ, Aronin N. Selective Neuronal Uptake and Distribution of AAVrh8, AAV9, and AAVrh10 in Sheep After Intra-Striatal Administration. J Huntingtons Dis. 2018; 7(4):309-319. PMID: 30320596.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    39. Sanchez-Ramos J, Song S, Kong X, Foroutan P, Martinez G, Dominguez-Viqueria W, Mohapatra S, Mohapatra S, Haraszti RA, Khvorova A, Aronin N, Sava V. Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain. J Drug Deliv Sci Technol. 2018 Feb; 43:453-460. PMID: 29805475.
    40. Romo L, Ashar-Patel A, Pfister E, Aronin N. Alterations in mRNA 3' UTR Isoform Abundance Accompany Gene Expression Changes in Human Huntington's Disease Brains. Cell Rep. 2017 Sep 26; 20(13):3057-3070. PMID: 28954224.
      Citations: 20     Fields:    Translation:HumansAnimals
    41. Alterman JF, Coles AH, Hall LM, Aronin N, Khvorova A, Didiot MC. A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons in vitro with Oligonucleotide Therapeutics. Bio Protoc. 2017 Aug 20; 7(16). PMID: 28966945.
    42. Haraszti RA, Roux L, Coles AH, Turanov AA, Alterman JF, Echeverria D, Godinho BMDC, Aronin N, Khvorova A. 5?-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo. Nucleic Acids Res. 2017 Jul 27; 45(13):7581-7592. PMID: 28591791.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    43. Haraszti RA, Coles A, Aronin N, Khvorova A, Didiot MC. Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System. Bio Protoc. 2017 Jun 20; 7(20). PMID: 28868334.
    44. Nikan M, Osborn MF, Coles AH, Biscans A, Godinho BMDC, Haraszti RA, Sapp E, Echeverria D, DiFiglia M, Aronin N, Khvorova A. Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain. Bioconjug Chem. 2017 06 21; 28(6):1758-1766. PMID: 28462988.
      Citations: 21     Fields:    Translation:Animals
    45. Miller JRC, Pfister EL, Liu W, Andre R, Tr?ger U, Kennington LA, Lo K, Dijkstra S, Macdonald D, Ostroff G, Aronin N, Tabrizi SJ. Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells. Sci Rep. 2017 04 24; 7:46740. PMID: 28436437.
      Citations: 12     Fields:    Translation:HumansCells
    46. Pfister EL, Chase KO, Sun H, Kennington LA, Conroy F, Johnson E, Miller R, Borel F, Aronin N, Mueller C. Safe and Efficient Silencing with a Pol II, but Not a Pol lII, Promoter Expressing an Artificial miRNA Targeting Human Huntingtin. Mol Ther Nucleic Acids. 2017 Jun 16; 7:324-334. PMID: 28624208.
    47. Haraszti RA, Didiot MC, Sapp E, Leszyk J, Shaffer SA, Rockwell HE, Gao F, Narain NR, DiFiglia M, Kiebish MA, Aronin N, Khvorova A. High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. J Extracell Vesicles. 2016; 5:32570. PMID: 27863537.
      Citations: 297     Fields:    
    48. Keeler AM, Sapp E, Chase K, Sottosanti E, Danielson E, Pfister E, Stoica L, DiFiglia M, Aronin N, Sena-Esteves M. Cellular Analysis of Silencing the?Huntington's Disease Gene Using AAV9?Mediated Delivery of Artificial Micro?RNA into the Striatum of?Q140/Q140?Mice. J Huntingtons Dis. 2016 10 01; 5(3):239-248. PMID: 27689620.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    49. Vodicka P, Chase K, Iuliano M, Tousley A, Valentine DT, Sapp E, Kegel-Gleason KB, Sena-Esteves M, Aronin N, DiFiglia M. Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016 10 01; 5(3):249-260. PMID: 27689619.
      Citations: 19     Fields:    Translation:HumansAnimals
    50. Nikan M, Osborn MF, Coles AH, Godinho BM, Hall LM, Haraszti RA, Hassler MR, Echeverria D, Aronin N, Khvorova A. Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain. Mol Ther Nucleic Acids. 2016 Aug 09; 5(8):e344. PMID: 27504598.
    51. Didiot MC, Hall LM, Coles AH, Haraszti RA, Godinho BM, Chase K, Sapp E, Ly S, Alterman JF, Hassler MR, Echeverria D, Raj L, Morrissey DV, DiFiglia M, Aronin N, Khvorova A. Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing. Mol Ther. 2016 10; 24(10):1836-1847. PMID: 27506293.
      Citations: 179     Fields:    Translation:HumansAnimalsCells
    52. Vodicka P, Chase K, Iuliano M, Valentine DT, Sapp E, Lu B, Kegel-Gleason KB, Sena-Esteves M, Aronin N, DiFiglia M. Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016 06 13; 5(2):163-74. PMID: 27314618.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    53. Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ. Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. Elife. 2016 Feb 24; 5:e10031. PMID: 26910012.
      Citations: 17     Fields:    Translation:AnimalsCells
    54. Liu W, Pfister EL, Kennington LA, Chase KO, Mueller C, DiFiglia M, Aronin N. Does the Mutant CAG Expansion in Huntingtin mRNA Interfere with Exonucleolytic Cleavage of its First Exon? J Huntingtons Dis. 2016; 5(1):33-8. PMID: 27003665.
      Citations: 2     Fields:    Translation:AnimalsCells
    55. Choudhury SR, Harris AF, Cabral DJ, Keeler AM, Sapp E, Ferreira JS, Gray-Edwards HL, Johnson JA, Johnson AK, Su Q, Stoica L, DiFiglia M, Aronin N, Martin DR, Gao G, Sena-Esteves M. Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector. Mol Ther. 2016 Apr; 24(4):726-35. PMID: 26708003.
      Citations: 58     Fields:    Translation:AnimalsCells
    56. Toledo RA, Qin Y, Cheng ZM, Gao Q, Iwata S, Silva GM, Prasad ML, Ocal IT, Rao S, Aronin N, Barontini M, Bruder J, Reddick RL, Chen Y, Aguiar RC, Dahia PL. Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas. Clin Cancer Res. 2016 05 01; 22(9):2301-10. PMID: 26700204.
      Citations: 55     Fields:    Translation:HumansCells
    57. Alterman JF, Hall LM, Coles AH, Hassler MR, Didiot MC, Chase K, Abraham J, Sottosanti E, Johnson E, Sapp E, Osborn MF, Difiglia M, Aronin N, Khvorova A. Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain. Mol Ther Nucleic Acids. 2015 Dec 01; 4:e266. PMID: 26623938.
    58. Coles AH, Osborn MF, Alterman JF, Turanov AA, Godinho BM, Kennington L, Chase K, Aronin N, Khvorova A. A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo. Nucleic Acid Ther. 2016 Apr; 26(2):86-92. PMID: 26595721.
      Citations: 28     Fields:    Translation:Animals
    59. Vodicka P, Mo S, Tousley A, Green KM, Sapp E, Iuliano M, Sadri-Vakili G, Shaffer SA, Aronin N, DiFiglia M, Kegel-Gleason KB. Mass Spectrometry Analysis of Wild-Type and Knock-in Q140/Q140 Huntington's Disease Mouse Brains Reveals Changes in Glycerophospholipids Including Alterations in Phosphatidic Acid and Lyso-Phosphatidic Acid. J Huntingtons Dis. 2015; 4(2):187-201. PMID: 26397899.
      Citations: 10     Fields:    Translation:AnimalsCells
    60. Johnson E, Chase K, McGowan S, Mondo E, Pfister E, Mick E, Friedline RH, Kim JK, Sapp E, DiFiglia M, Aronin N. Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model. J Huntingtons Dis. 2015; 4(3):219-229. PMID: 26444021.
      Citations: 3     Fields:    Translation:Animals
    61. Zhu LJ, Holmes BR, Aronin N, Brodsky MH. CRISPRseek: a bioconductor package to identify target-specific guide RNAs for CRISPR-Cas9 genome-editing systems. PLoS One. 2014; 9(9):e108424. PMID: 25247697.
      Citations: 88     Fields:    Translation:HumansCells
    62. Aronin N, DiFiglia M. Huntingtin-lowering strategies in Huntington's disease: antisense oligonucleotides, small RNAs, and gene editing. Mov Disord. 2014 Sep 15; 29(11):1455-61. PMID: 25164989.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    63. Evans MS, Chaurette JP, Adams ST, Reddy GR, Paley MA, Aronin N, Prescher JA, Miller SC. A synthetic luciferin improves bioluminescence imaging in live mice. Nat Methods. 2014 Apr; 11(4):393-5. PMID: 24509630.
      Citations: 77     Fields:    Translation:AnimalsCells
    64. Tr?ger U, Andre R, Lahiri N, Magnusson-Lind A, Weiss A, Grueninger S, McKinnon C, Sirinathsinghji E, Kahlon S, Pfister EL, Moser R, Hummerich H, Antoniou M, Bates GP, Luthi-Carter R, Lowdell MW, Bj?rkqvist M, Ostroff GR, Aronin N, Tabrizi SJ. HTT-lowering reverses Huntington's disease immune dysfunction caused by NF?B pathway dysregulation. Brain. 2014 Mar; 137(Pt 3):819-33. PMID: 24459107.
      Citations: 84     Fields:    Translation:HumansCells
    65. Vodicka P, Lim J, Williams DT, Kegel KB, Chase K, Park H, Marchionini D, Wilkinson S, Mead T, Birch H, Yates D, Lyons K, Dominguez C, Beconi M, Yue Z, Aronin N, DiFiglia M. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014; 3(2):159-74. PMID: 25062859.
      Citations: 13     Fields:    Translation:Animals
    66. van der Bom IM, Moser RP, Gao G, Mondo E, O'Connell D, Gounis MJ, McGowan S, Chaurette J, Bishop N, Sena-Esteves MS, Mueller C, Aronin N. Finding the striatum in sheep: use of a multi-modal guided approach for convection enhanced delivery. J Huntingtons Dis. 2013; 2(1):41-5. PMID: 25063428.
      Citations: 5     Fields:    Translation:AnimalsCells
    67. Valencia A, Sapp E, Kimm JS, McClory H, Ansong KA, Yohrling G, Kwak S, Kegel KB, Green KM, Shaffer SA, Aronin N, DiFiglia M. Striatal synaptosomes from Hdh140Q/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation. J Huntingtons Dis. 2013; 2(4):459-75. PMID: 24696705.
      Citations: 19     Fields:    Translation:AnimalsCells
    68. Liu W, Chaurette J, Pfister EL, Kennington LA, Chase KO, Bullock J, Vonsattel JP, Faull RL, Macdonald D, DiFiglia M, Zamore PD, Aronin N. Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain. J Huntingtons Dis. 2013; 2(4):491-500. PMID: 25062733.
      Citations: 9     Fields:    Translation:HumansCells
    69. Aronin N, Moore M. Hunting down huntingtin. N Engl J Med. 2012 11 01; 367(18):1753-4. PMID: 23113488.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    70. Sapp E, Valencia A, Li X, Aronin N, Kegel KB, Vonsattel JP, Young AB, Wexler N, DiFiglia M. Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer. J Biol Chem. 2012 Apr 13; 287(16):13487-99. PMID: 22375012.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    71. van der Bom IM, Moser RP, Gao G, Sena-Esteves M, Aronin N, Gounis MJ. Frameless multimodal image guidance of localized convection-enhanced delivery of therapeutics in the brain. J Neurointerv Surg. 2013 Jan 01; 5(1):69-72. PMID: 22193239.
      Citations: 6     Fields:    Translation:AnimalsCells
    72. Broderick JA, Salomon WE, Ryder SP, Aronin N, Zamore PD. Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing. RNA. 2011 Oct; 17(10):1858-69. PMID: 21878547.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    73. Sah DW, Aronin N. Oligonucleotide therapeutic approaches for Huntington disease. J Clin Invest. 2011 Feb; 121(2):500-7. PMID: 21285523.
      Citations: 63     Fields:    Translation:HumansCells
    74. Kegel KB, Sapp E, Alexander J, Reeves P, Bleckmann D, Sobin L, Masso N, Valencia A, Jeong H, Krainc D, Palacino J, Curtis D, Kuhn R, Betschart C, Sena-Esteves M, Aronin N, Paganetti P, Difiglia M. Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors. Mol Neurodegener. 2010 Dec 14; 5:58. PMID: 21156064.
      Citations: 12     Fields:    
    75. Li X, Valencia A, Sapp E, Masso N, Alexander J, Reeves P, Kegel KB, Aronin N, Difiglia M. Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease. J Neurosci. 2010 Mar 31; 30(13):4552-61. PMID: 20357106.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    76. Qin Y, Yao L, King EE, Buddavarapu K, Lenci RE, Chocron ES, Lechleiter JD, Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G, Toledo RA, Toledo SP, Stiles C, Aguiar RC, Dahia PL. Germline mutations in TMEM127 confer susceptibility to pheochromocytoma. Nat Genet. 2010 Mar; 42(3):229-33. PMID: 20154675.
      Citations: 170     Fields:    Translation:HumansCells
    77. Valencia A, Reeves PB, Sapp E, Li X, Alexander J, Kegel KB, Chase K, Aronin N, DiFiglia M. Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease. J Neurosci Res. 2010 Jan; 88(1):179-90. PMID: 19642201.
      Citations: 44     Fields:    Translation:AnimalsCells
    78. Li X, Standley C, Sapp E, Valencia A, Qin ZH, Kegel KB, Yoder J, Comer-Tierney LA, Esteves M, Chase K, Alexander J, Masso N, Sobin L, Bellve K, Tuft R, Lifshitz L, Fogarty K, Aronin N, DiFiglia M. Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity. Mol Cell Biol. 2009 Nov; 29(22):6106-16. PMID: 19752198.
      Citations: 56     Fields:    Translation:HumansCells
    79. Li X, Sapp E, Chase K, Comer-Tierney LA, Masso N, Alexander J, Reeves P, Kegel KB, Valencia A, Esteves M, Aronin N, Difiglia M. Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease. Neurobiol Dis. 2009 Nov; 36(2):374-83. PMID: 19699304.
      Citations: 40     Fields:    Translation:AnimalsCells
    80. Kegel KB, Sapp E, Alexander J, Valencia A, Reeves P, Li X, Masso N, Sobin L, Aronin N, DiFiglia M. Polyglutamine expansion in huntingtin alters its interaction with phospholipids. J Neurochem. 2009 Sep; 110(5):1585-97. PMID: 19566678.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    81. Aronin N. Expanded CAG repeats in the crosshairs. Nat Biotechnol. 2009 May; 27(5):451-2. PMID: 19430450.
      Citations: 1     Fields:    Translation:HumansCells
    82. Pfister EL, Kennington L, Straubhaar J, Wagh S, Liu W, DiFiglia M, Landwehrmeyer B, Vonsattel JP, Zamore PD, Aronin N. Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients. Curr Biol. 2009 May 12; 19(9):774-8. PMID: 19361997.
      Citations: 127     Fields:    Translation:Humans
    83. Li X, Sapp E, Valencia A, Kegel KB, Qin ZH, Alexander J, Masso N, Reeves P, Ritch JJ, Zeitlin S, Aronin N, Difiglia M. A function of huntingtin in guanine nucleotide exchange on Rab11. Neuroreport. 2008 Oct 29; 19(16):1643-7. PMID: 18845944.
      Citations: 34     Fields:    Translation:AnimalsCells
    84. Liu W, Kennington LA, Rosas HD, Hersch S, Cha JH, Zamore PD, Aronin N. Linking SNPs to CAG repeat length in Huntington's disease patients. Nat Methods. 2008 Nov; 5(11):951-3. PMID: 18931668.
      Citations: 18     Fields:    Translation:HumansCells
    85. DiFiglia M, Sena-Esteves M, Chase K, Sapp E, Pfister E, Sass M, Yoder J, Reeves P, Pandey RK, Rajeev KG, Manoharan M, Sah DW, Zamore PD, Aronin N. Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17204-9. PMID: 17940007.
      Citations: 200     Fields:    Translation:HumansAnimalsCells
    86. Schwarz DS, Ding H, Kennington L, Moore JT, Schelter J, Burchard J, Linsley PS, Aronin N, Xu Z, Zamore PD. Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS Genet. 2006 Sep 08; 2(9):e140. PMID: 16965178.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    87. Aronin N. Target selectivity in mRNA silencing. Gene Ther. 2006 Mar; 13(6):509-16. PMID: 16520821.
      Citations: 9     Fields:    Translation:HumansAnimals
    88. Kim YJ, Sapp E, Cuiffo BG, Sobin L, Yoder J, Kegel KB, Qin ZH, Detloff P, Aronin N, DiFiglia M. Lysosomal proteases are involved in generation of N-terminal huntingtin fragments. Neurobiol Dis. 2006 May; 22(2):346-56. PMID: 16423528.
      Citations: 32     Fields:    Translation:AnimalsCells
    89. Dahia PL, Hao K, Rogus J, Colin C, Pujana MA, Ross K, Magoffin D, Aronin N, Cascon A, Hayashida CY, Li C, Toledo SP, Stiles CD. Novel pheochromocytoma susceptibility loci identified by integrative genomics. Cancer Res. 2005 Nov 01; 65(21):9651-8. PMID: 16266984.
      Citations: 31     Fields:    Translation:HumansCells
    90. Schwartz WJ, Aronin N, Sassone-Corsi P. Photoinducible and rhythmic ICER-CREM immunoreactivity in the rat suprachiasmatic nucleus. Neurosci Lett. 2005 Sep 02; 385(1):87-91. PMID: 15936880.
      Citations: 5     Fields:    Translation:Animals
    91. Kegel KB, Sapp E, Yoder J, Cuiffo B, Sobin L, Kim YJ, Qin ZH, Hayden MR, Aronin N, Scott DL, Isenberg G, Goldmann WH, DiFiglia M. Huntingtin associates with acidic phospholipids at the plasma membrane. J Biol Chem. 2005 Oct 28; 280(43):36464-73. PMID: 16085648.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    92. Ariano MA, Cepeda C, Calvert CR, Flores-Hern?ndez J, Hern?ndez-Echeagaray E, Klapstein GJ, Chandler SH, Aronin N, DiFiglia M, Levine MS. Striatal potassium channel dysfunction in Huntington's disease transgenic mice. J Neurophysiol. 2005 May; 93(5):2565-74. PMID: 15625098.
      Citations: 57     Fields:    Translation:AnimalsCells
    93. Qin ZH, Wang Y, Sapp E, Cuiffo B, Wanker E, Hayden MR, Kegel KB, Aronin N, DiFiglia M. Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction. J Neurosci. 2004 Jan 07; 24(1):269-81. PMID: 14715959.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    94. Qin ZH, Wang Y, Kegel KB, Kazantsev A, Apostol BL, Thompson LM, Yoder J, Aronin N, DiFiglia M. Autophagy regulates the processing of amino terminal huntingtin fragments. Hum Mol Genet. 2003 Dec 15; 12(24):3231-44. PMID: 14570716.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    95. Schwarz DS, Hutv?gner G, Du T, Xu Z, Aronin N, Zamore PD. Asymmetry in the assembly of the RNAi enzyme complex. Cell. 2003 Oct 17; 115(2):199-208. PMID: 14567917.
      Citations: 1086     Fields:    Translation:AnimalsCells
    96. Kim M, Roh JK, Yoon BW, Kang L, Kim YJ, Aronin N, DiFiglia M. Huntingtin is degraded to small fragments by calpain after ischemic injury. Exp Neurol. 2003 Sep; 183(1):109-15. PMID: 12957494.
      Citations: 12     Fields:    Translation:AnimalsCells
    97. Zamore PD, Aronin N. siRNAs knock down hepatitis. Nat Med. 2003 Mar; 9(3):266-7. PMID: 12612573.
      Citations: 6     Fields:    Translation:HumansAnimals
    98. Chan EY, Luthi-Carter R, Strand A, Solano SM, Hanson SA, DeJohn MM, Kooperberg C, Chase KO, DiFiglia M, Young AB, Leavitt BR, Cha JH, Aronin N, Hayden MR, Olson JM. Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease. Hum Mol Genet. 2002 Aug 15; 11(17):1939-51. PMID: 12165556.
      Citations: 42     Fields:    Translation:HumansAnimals
    99. Ariano MA, Aronin N, Difiglia M, Tagle DA, Sibley DR, Leavitt BR, Hayden MR, Levine MS. Striatal neurochemical changes in transgenic models of Huntington's disease. J Neurosci Res. 2002 Jun 15; 68(6):716-29. PMID: 12111832.
      Citations: 35     Fields:    Translation:AnimalsCells
    100. Peters?n A, Chase K, Puschban Z, DiFiglia M, Brundin P, Aronin N. Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease. Exp Neurol. 2002 May; 175(1):297-300. PMID: 12009780.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    101. Kegel KB, Meloni AR, Yi Y, Kim YJ, Doyle E, Cuiffo BG, Sapp E, Wang Y, Qin ZH, Chen JD, Nevins JR, Aronin N, DiFiglia M. Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription. J Biol Chem. 2002 Mar 01; 277(9):7466-76. PMID: 11739372.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    102. Laforet GA, Sapp E, Chase K, McIntyre C, Boyce FM, Campbell M, Cadigan BA, Warzecki L, Tagle DA, Reddy PH, Cepeda C, Calvert CR, Jokel ES, Klapstein GJ, Ariano MA, Levine MS, DiFiglia M, Aronin N. Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease. J Neurosci. 2001 Dec 01; 21(23):9112-23. PMID: 11717344.
      Citations: 97     Fields:    Translation:AnimalsCells
    103. Kim YJ, Yi Y, Sapp E, Wang Y, Cuiffo B, Kegel KB, Qin ZH, Aronin N, DiFiglia M. Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12784-9. PMID: 11675509.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    104. Sapp E, Kegel KB, Aronin N, Hashikawa T, Uchiyama Y, Tohyama K, Bhide PG, Vonsattel JP, DiFiglia M. Early and progressive accumulation of reactive microglia in the Huntington disease brain. J Neuropathol Exp Neurol. 2001 Feb; 60(2):161-72. PMID: 11273004.
      Citations: 206     Fields:    Translation:HumansCells
    105. Qin ZH, Wang Y, Kikly KK, Sapp E, Kegel KB, Aronin N, DiFiglia M. Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation. J Biol Chem. 2001 Mar 16; 276(11):8079-86. PMID: 11102441.
      Citations: 24     Fields:    Translation:HumansCells
    106. Kegel KB, Kim M, Sapp E, McIntyre C, Casta?o JG, Aronin N, DiFiglia M. Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. J Neurosci. 2000 Oct 01; 20(19):7268-78. PMID: 11007884.
      Citations: 182     Fields:    Translation:AnimalsCells
    107. Schwartz WJ, Carpino A, de la Iglesia HO, Baler R, Klein DC, Nakabeppu Y, Aronin N. Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus. Neuroscience. 2000; 98(3):535-47. PMID: 10869847.
      Citations: 33     Fields:    Translation:Animals
    108. Aronin N, Kim M, Laforet G, DiFiglia M. Are there multiple pathways in the pathogenesis of Huntington's disease? Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29; 354(1386):995-1003. PMID: 10434298.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    109. Sapp E, Penney J, Young A, Aronin N, Vonsattel JP, DiFiglia M. Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease. J Neuropathol Exp Neurol. 1999 Feb; 58(2):165-73. PMID: 10029099.
      Citations: 46     Fields:    Translation:HumansCells
    110. Kim M, Lee HS, LaForet G, McIntyre C, Martin EJ, Chang P, Kim TW, Williams M, Reddy PH, Tagle D, Boyce FM, Won L, Heller A, Aronin N, DiFiglia M. Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition. J Neurosci. 1999 Feb 01; 19(3):964-73. PMID: 9920660.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    111. Martin EJ, Kim M, Velier J, Sapp E, Lee HS, Laforet G, Won L, Chase K, Bhide PG, Heller A, Aronin N, Difiglia M. Analysis of Huntingtin-associated protein 1 in mouse brain and immortalized striatal neurons. J Comp Neurol. 1999 Jan 25; 403(4):421-30. PMID: 9888310.
      Citations: 22     Fields:    Translation:AnimalsCells
    112. Kim M, Velier J, Chase K, Laforet G, Kalchman MA, Hayden MR, Won L, Heller A, Aronin N, Difiglia M. Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin. Neuroscience. 1999; 89(4):1159-67. PMID: 10362304.
      Citations: 13     Fields:    Translation:AnimalsCells
    113. Velier J, Kim M, Schwarz C, Kim TW, Sapp E, Chase K, Aronin N, DiFiglia M. Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways. Exp Neurol. 1998 Jul; 152(1):34-40. PMID: 9682010.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    114. Davies SW, Beardsall K, Turmaine M, DiFiglia M, Aronin N, Bates GP. Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions? Lancet. 1998 Jan 10; 351(9096):131-3. PMID: 9439509.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    115. Sapp E, Schwarz C, Chase K, Bhide PG, Young AB, Penney J, Vonsattel JP, Aronin N, DiFiglia M. Huntingtin localization in brains of normal and Huntington's disease patients. Ann Neurol. 1997 Oct; 42(4):604-12. PMID: 9382472.
      Citations: 110     Fields:    Translation:HumansCells
    116. DiFiglia M, Sapp E, Chase KO, Davies SW, Bates GP, Vonsattel JP, Aronin N. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science. 1997 Sep 26; 277(5334):1990-3. PMID: 9302293.
      Citations: 957     Fields:    Translation:HumansCells
    117. Block-Galarza J, Chase KO, Sapp E, Vaughn KT, Vallee RB, DiFiglia M, Aronin N. Fast transport and retrograde movement of huntingtin and HAP 1 in axons. Neuroreport. 1997 Jul 07; 8(9-10):2247-51. PMID: 9243620.
      Citations: 41     Fields:    Translation:AnimalsCells
    118. Melloni RH, Aronin N, DeGennaro LJ, Ferris CF, Harrison RJ. Dde-I restriction endonuclease fragmentation: a novel method of generating cDNA probes for in situ hybridization in brain. J Histochem Cytochem. 1997 May; 45(5):755-63. PMID: 9154163.
      Citations: 1     Fields:    Translation:Animals
    119. Stock JL, Warth MR, Teh BT, Coderre JA, Overdorf JH, Baumann G, Hintz RL, Hartman ML, Seizinger BR, Larsson C, Aronin N. A kindred with a variant of multiple endocrine neoplasia type 1 demonstrating frequent expression of pituitary tumors but not linked to the multiple endocrine neoplasia type 1 locus at chromosome region 11q13. J Clin Endocrinol Metab. 1997 Feb; 82(2):486-92. PMID: 9024241.
      Citations: 8     Fields:    Translation:HumansCells
    120. Bennett MR, Aronin N, Schwartz WJ. In vitro stimulation of c-Fos protein expression in the suprachiasmatic nucleus of hypothalamic slices. Brain Res Mol Brain Res. 1996 Nov; 42(1):140-4. PMID: 8915592.
      Citations: 2     Fields:    Translation:Animals
    121. Bhide PG, Day M, Sapp E, Schwarz C, Sheth A, Kim J, Young AB, Penney J, Golden J, Aronin N, DiFiglia M. Expression of normal and mutant huntingtin in the developing brain. J Neurosci. 1996 Sep 01; 16(17):5523-35. PMID: 8757264.
      Citations: 68     Fields:    Translation:HumansAnimals
    122. Peters RV, Aronin N, Schwartz WJ. c-Fos expression in the rat intergeniculate leaflet: photic regulation, co-localization with Fos-B, and cellular identification. Brain Res. 1996 Jul 29; 728(2):231-41. PMID: 8864487.
      Citations: 4     Fields:    Translation:Animals
    123. Schwartz WJ, Peters RV, Aronin N, Bennett MR. Unexpected c-fos gene expression in the suprachiasmatic nucleus of mice entrained to a skeleton photoperiod. J Biol Rhythms. 1996 Mar; 11(1):35-44. PMID: 8695890.
      Citations: 5     Fields:    Translation:Animals
    124. Mello CJ, Veronikis I, Fraire AE, Aronin N, Irwin RS, Braverman LE. Metastatic papillary thyroid carcinoma to lung diagnosed by bronchoalveolar lavage. J Clin Endocrinol Metab. 1996 Jan; 81(1):406-10. PMID: 8550785.
      Citations:    Fields:    Translation:Humans
    125. Aronin N, Chase K, Young C, Sapp E, Schwarz C, Matta N, Kornreich R, Landwehrmeyer B, Bird E, Beal MF, et al. CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain. Neuron. 1995 Nov; 15(5):1193-201. PMID: 7576661.
      Citations: 56     Fields:    Translation:HumansCells
    126. Birnbaum MJ, Wright KL, van Wijnen AJ, Ramsey-Ewing AL, Bourke MT, Last TJ, Aziz F, Frenkel B, Rao BR, Aronin N, et al. Functional role for Sp1 in the transcriptional amplification of a cell cycle regulated histone H4 gene. Biochemistry. 1995 Jun 13; 34(23):7648-58. PMID: 7779811.
      Citations: 10     Fields:    Translation:HumansCells
    127. Peters RV, Aronin N, Schwartz WJ. Circadian regulation of Fos B is different from c-Fos in the rat suprachiasmatic nucleus. Brain Res Mol Brain Res. 1994 Dec; 27(2):243-8. PMID: 7898307.
      Citations: 3     Fields:    Translation:Animals
    128. Schwartz WJ, Takeuchi J, Shannon W, Davis EM, Aronin N. Temporal regulation of light-induced Fos and Fos-like protein expression in the ventrolateral subdivision of the rat suprachiasmatic nucleus. Neuroscience. 1994 Feb; 58(3):573-83. PMID: 8170538.
      Citations: 14     Fields:    Translation:Animals
    129. Takeuchi J, Shannon W, Aronin N, Schwartz WJ. Compositional changes of AP-1 DNA-binding proteins are regulated by light in a mammalian circadian clock. Neuron. 1993 Nov; 11(5):825-36. PMID: 8240806.
      Citations: 12     Fields:    Translation:AnimalsCells
    130. Lester J, Fink S, Aronin N, DiFiglia M. Colocalization of D1 and D2 dopamine receptor mRNAs in striatal neurons. Brain Res. 1993 Sep 03; 621(1):106-10. PMID: 8221060.
      Citations: 25     Fields:    Translation:AnimalsCells
    131. Lacomis D, Chad DA, Aronin N, Smith TW. The myopathy of Cushing's syndrome. Muscle Nerve. 1993 Aug; 16(8):880-1. PMID: 8332144.
      Citations: 1     Fields:    Translation:Humans
    132. Huang Q, Zhou D, Chase K, Gusella JF, Aronin N, DiFiglia M. Immunohistochemical localization of the D1 dopamine receptor in rat brain reveals its axonal transport, pre- and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus. Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):11988-92. PMID: 1281547.
      Citations: 65     Fields:    Translation:AnimalsCells
    133. Aronin N, DiFiglia M. The subcellular localization of the G-protein Gi alpha in the basal ganglia reveals its potential role in both signal transduction and vesicle trafficking. J Neurosci. 1992 Sep; 12(9):3435-44. PMID: 1527588.
      Citations: 10     Fields:    Translation:AnimalsCells
    134. Gerbaulet SP, van Wijnen AJ, Aronin N, Tassinari MS, Lian JB, Stein JL, Stein GS. Downregulation of histone H4 gene transcription during postnatal development in transgenic mice and at the onset of differentiation in transgenically derived calvarial osteoblast cultures. J Cell Biochem. 1992 Jun; 49(2):137-47. PMID: 1400621.
      Citations: 5     Fields:    Translation:AnimalsCells
    135. Bouckoms AJ, Sweet WH, Poletti C, Lavori P, Carr D, Matson W, Gamache P, Aronin N. Monoamines in the brain cerebrospinal fluid of facial pain patients. Anesth Prog. 1992; 39(6):201-8. PMID: 7504420.
      Citations: 7     Fields:    Translation:Humans
    136. Aronin N, Chase K, Folsom R, Christakos S, DiFiglia M. Immunoreactive calcium-binding protein (calbindin-D28k) in interneurons and trigeminothalamic neurons of the rat nucleus caudalis localized with peroxidase and immunogold methods. Synapse. 1991 Feb; 7(2):106-13. PMID: 1707189.
      Citations: 2     Fields:    Translation:AnimalsCells
    137. Chipkin SR, Gottlieb P, Lundstrom R, Leppo J, Aronin N. Transient myocardial perfusion abnormalities in diabetic patients: a prospective study using thallium exercise tolerance testing. Cardiology. 1991; 79(3):172-9. PMID: 1769034.
      Citations:    Fields:    Translation:Humans
    138. Aronin N, Chase K, Sagar SM, Sharp FR, DiFiglia M. N-methyl-D-aspartate receptor activation in the neostriatum increases c-fos and fos-related antigens selectively in medium-sized neurons. Neuroscience. 1991; 44(2):409-20. PMID: 1834961.
      Citations: 8     Fields:    Translation:AnimalsCells
    139. Owen TA, Bortell R, Yocum SA, Smock SL, Zhang M, Abate C, Shalhoub V, Aronin N, Wright KL, van Wijnen AJ, et al. Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription. Proc Natl Acad Sci U S A. 1990 Dec; 87(24):9990-4. PMID: 2124710.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    140. Chad DA, Aronin N, Lundstrom R, McKeon P, Ross D, Molitch M, Schipper HM, Stall G, Dyess E, Tarsy D. Does capsaicin relieve the pain of diabetic neuropathy? Pain. 1990 Sep; 42(3):387-388. PMID: 1701234.
      Citations: 11     Fields:    Translation:Humans
    141. Aronin N, Sagar SM, Sharp FR, Schwartz WJ. Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei. Proc Natl Acad Sci U S A. 1990 Aug; 87(15):5959-62. PMID: 2116012.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    142. Madras BK, Canfield DR, Pfaelzer C, Vittimberga FJ, Difiglia M, Aronin N, Bakthavachalam V, Baindur N, Neumeyer JL. Fluorescent and biotin probes for dopamine receptors: D1 and D2 receptor affinity and selectivity. Mol Pharmacol. 1990 Jun; 37(6):833-9. PMID: 2141665.
      Citations: 7     Fields:    Translation:Animals
    143. DiFiglia M, Aronin N. Synaptic interactions between GABAergic neurons and trigeminothalamic cells in the rat trigeminal nucleus caudalis. Synapse. 1990; 6(4):358-63. PMID: 1705057.
      Citations: 3     Fields:    Translation:AnimalsCells
    144. Alpert JS, Chipkin SR, Aronin N. Diabetes mellitus and silent myocardial ischemia. Adv Cardiol. 1990; 37:297-303. PMID: 2220457.
      Citations: 2     Fields:    Translation:Humans
    145. DiFiglia M, Christakos S, Aronin N. Ultrastructural localization of immunoreactive calbindin-D28k in the rat and monkey basal ganglia, including subcellular distribution with colloidal gold labeling. J Comp Neurol. 1989 Jan 22; 279(4):653-65. PMID: 2918090.
      Citations: 8     Fields:    Translation:HumansAnimals
    146. Aronin N, Coslovsky R, Chase K. Hypothyroidism increases substance P concentrations in the heterotopic anterior pituitary. Endocrinology. 1988 Jun; 122(6):2911-4. PMID: 2453352.
      Citations: 2     Fields:    Translation:Animals
    147. Chipkin SR, Stoff JS, Aronin N. Immunohistochemical evidence for neural mediation of VIP activity in the dogfish rectal gland. Peptides. 1988 Jan-Feb; 9(1):119-24. PMID: 3362739.
      Citations: 1     Fields:    Translation:AnimalsCells
    148. Aronin N, Leeman SE, Clements RS. Diminished flare response in neuropathic diabetic patients. Comparison of effects of substance P, histamine, and capsaicin. Diabetes. 1987 Oct; 36(10):1139-43. PMID: 2443407.
      Citations: 6     Fields:    Translation:HumansCells
    149. Rafols JA, Aronin N, Difiglia M. A Golgi study of the monkey paraventricular nucleus: neuronal types, afferent and efferent fibers. J Comp Neurol. 1987 Mar 22; 257(4):595-613. PMID: 2447130.
      Citations: 2     Fields:    Translation:AnimalsCells
    150. Chipkin SR, Frid D, Alpert JS, Baker SP, Dalen JE, Aronin N. Frequency of painless myocardial ischemia during exercise tolerance testing in patients with and without diabetes mellitus. Am J Cardiol. 1987 Jan 01; 59(1):61-5. PMID: 3812254.
      Citations: 5     Fields:    Translation:Humans
    151. Aronin N, Chase K, DiFiglia M. Glutamic acid decarboxylase and enkephalin immunoreactive axon terminals in the rat neostriatum synapse with striatonigral neurons. Brain Res. 1986 Feb 12; 365(1):151-8. PMID: 3512036.
      Citations: 4     Fields:    Translation:AnimalsCells
    152. Aronin N, Coslovsky R, Leeman SE. Substance P and neurotensin: their roles in the regulation of anterior pituitary function. Annu Rev Physiol. 1986; 48:537-49. PMID: 2423025.
      Citations: 7     Fields:    Translation:Animals
    153. Coslovsky R, Braverman LE, Leeman SE, Aronin N. The differential effects of thyroid and gonadal hormones on substance P content in the anterior pituitary of the prepubertal rat. Endocrinology. 1985 Nov; 117(5):2198-202. PMID: 2412805.
      Citations: 2     Fields:    Translation:Animals
    154. Coslovsky R, Evans RW, Leeman SE, Braverman LE, Aronin N. The effects of gonadal steroids on the content of substance P in the rat anterior pituitary. Endocrinology. 1984 Dec; 115(6):2285-9. PMID: 6209122.
      Citations: 2     Fields:    Translation:Animals
    155. DiFiglia M, Aronin N. Quantitative electron microscopic study of immunoreactive somatostatin axons in the rat neostriatum. Neurosci Lett. 1984 Sep 07; 50(1-3):325-31. PMID: 6149504.
      Citations:    Fields:    Translation:Animals
    156. Martino E, Safran M, Aghini-Lombardi F, Rajatanavin R, Lenziardi M, Fay M, Pacchiarotti A, Aronin N, Macchia E, Haffajee C, et al. Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy. Ann Intern Med. 1984 Jul; 101(1):28-34. PMID: 6428291.
      Citations: 71     Fields:    Translation:Humans
    157. Aronin N, Morency K, Leeman SE, Braverman LE, Coslovsky R. Regulation by thyroid hormone of the concentration of substance P in the rat anterior pituitary. Endocrinology. 1984 Jun; 114(6):2138-42. PMID: 6202496.
      Citations: 1     Fields:    Translation:Animals
    158. Aronin N, Difiglia M, Graveland GA, Schwartz WJ, Wu JY. Localization of immunoreactive enkephalins in GABA synthesizing neurons of the rat neostriatum. Brain Res. 1984 May 23; 300(2):376-80. PMID: 6375810.
      Citations: 20     Fields:    Translation:Animals
    159. DiFiglia M, Aronin N. Immunoreactive leu-enkephalin in the monkey hypothalamus including observations on its ultrastructural localization in the paraventricular nucleus. J Comp Neurol. 1984 May 20; 225(3):313-26. PMID: 6144702.
      Citations: 1     Fields:    Translation:AnimalsCells
    160. Difiglia M, Aronin N, Leeman SE. Ultrastructural localization of immunoreactive neurotensin in the monkey superficial dorsal horn. J Comp Neurol. 1984 May 01; 225(1):1-12. PMID: 6373845.
      Citations: 3     Fields:    Translation:AnimalsCells
    161. Maciewicz R, Phipps BS, Foote WE, Aronin N, DiFiglia M. The distribution of substance P-containing neurons in the cat Edinger-Westphal nucleus: relationship to efferent projection systems. Brain Res. 1983 Jul 04; 270(2):217-30. PMID: 6192874.
      Citations: 16     Fields:    Translation:Animals
    162. Aronin N, Cooper PE, Lorenz LJ, Bird ED, Sagar SM, Leeman SE, Martin JB. Somatostatin is increased in the basal ganglia in Huntington disease. Ann Neurol. 1983 May; 13(5):519-26. PMID: 6191621.
      Citations: 13     Fields:    Translation:Humans
    163. Aronin N, Krieger DT. Plasma immunoreactive beta-endorphin is elevated in uraemia. Clin Endocrinol (Oxf). 1983 May; 18(5):459-64. PMID: 6307552.
      Citations: 3     Fields:    Translation:Humans
    164. DiFiglia M, Aronin N. Ultrastructural features of immunoreactive somatostatin neurons in the rat caudate nucleus. J Neurosci. 1982 Sep; 2(9):1267-74. PMID: 6126530.
      Citations: 21     Fields:    Translation:AnimalsCells
    165. Aronin N, Carraway RE, Ferris CF, Hammer RA, Leeman SE. The stability and metabolism of intravenously administered neurotensin in the rat. Peptides. 1982 Jul-Aug; 3(4):637-42. PMID: 7134032.
      Citations: 19     Fields:    Translation:Animals
    166. DiFiglia M, Aronin N, Leeman SE. Light microscopic and ultrastructural localization of immunoreactive substance P in the dorsal horn of monkey spinal cord. Neuroscience. 1982 May; 7(5):1127-39. PMID: 6180349.
      Citations: 8     Fields:    Translation:AnimalsCells
    167. Bybee DE, Wiesen M, Aronin N, Krieger DT, Frohman LA, Kopin IJ. Failure of bromocriptine to lower plasma catecholamines in normal men and women. J Clin Endocrinol Metab. 1982 Mar; 54(3):648-50. PMID: 6276434.
      Citations: 4     Fields:    Translation:Humans
    168. DiFiglia M, Aronin N, Martin JB. Light and electron microscopic localization of immunoreactive Leu-enkephalin in the monkey basal ganglia. J Neurosci. 1982 Mar; 2(3):303-20. PMID: 6121017.
      Citations: 11     Fields:    Translation:AnimalsCells
    169. DiFiglia M, Aronin N, Leeman SE. Immunoreactive substance P in the substantia nigra of the monkey: light and electron microscopic localization. Brain Res. 1982 Feb 11; 233(2):381-8. PMID: 6174178.
      Citations: 3     Fields:    Translation:AnimalsCells
    170. Leeman SE, Aronin N, Ferris C. Substance P and neurotensin. Recent Prog Horm Res. 1982; 38:93-132. PMID: 6181544.
      Citations: 4     Fields:    Translation:HumansAnimals
    171. Aronin N, Liotta AS, Shickmanter B, Schussler GC, Krieger DT. Impaired clearance of beta-lipotropin in uremia. J Clin Endocrinol Metab. 1981 Oct; 53(4):797-800. PMID: 6270175.
      Citations:    Fields:    Translation:Humans
    172. Aronin N, Wiesen M, Liotta AS, Schussler GC, Krieger DT. Comparative metabolic clearance rates of beta-endorphin and beta-lipotropin in humans. Life Sci. 1981 Sep 21; 29(12):1265-9. PMID: 6272041.
      Citations: 2     Fields:    Translation:Humans
    173. Aronin N, DiFiglia M, Liotta AS, Martin JB. Ultrastructural localization and biochemical features of immunoreactive LEU-enkephalin in monkey dorsal horn. J Neurosci. 1981 Jun; 1(6):561-77. PMID: 6286896.
      Citations: 11     Fields:    Translation:AnimalsCells
    174. Mahony C, Hindman MC, Aronin N, Wagner GS. Prognostic differences in subgroups of patients with electrographic evidence of subendocardial or transmural myocardial infarction. The favorable outlook for patients with an initially normal QRS complex. Am J Med. 1980 Aug; 69(2):183-6. PMID: 7405943.
      Citations: 3     Fields:    Translation:Humans
    175. Aronin N, Krieger DT. Sustained remission of Nelson's syndrome after stopping cyproheptadine treatment. N Engl J Med. 1980 Feb 21; 302(8):453-5. PMID: 6243392.
      Citations: 6     Fields:    Translation:Humans
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