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Neil Aronin MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB-225
Worcester MA 01605
Phone508-856-3239
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionEndocrinology & Metabolism

    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - School of Medicine
    DepartmentRadiology

    InstitutionUMMS - School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCell Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Duke University, Durham, NC, United StatesBAHistory
    University of Pennsylvania Pereleman School of Medicine, Philadelphia, PA, United StatesMD

    Collapse Overview 
    Collapse overview

    Background

    • Undergraduate: Duke University, 1966-1970
    • Medical School: University of Pennsylvania, 1970-1974
    • Internship and Residency: Duke University Medical Center, 1974-1977
    • Research Fellowship: Massachusetts General Hospital and Harvard MedicalSchool, 1979-1981

    Positions

    • University of Massachusetts Medical School, 1981 - present,
    • Professor of Medicine and Cell Biology,
    • Director of Endocrinology and Metabolism

    Board Certifications

    • Internal Medicine, Endocrinology and Metabolism

    Huntington's Disease

    Photo: Neil AroninMy clinical interests focus on neuroendocrinology (pituitary and hypothalamic diseases), inherited endocrine diseases, and adrenal problems. We are currently conducting research in the treatment of patients with impaired pituitary function. My basic research centers on the pathogensis of neurodegenerative diseases, especially Parkinson's disease and Huntington's disease.

    Dr. Aronin's Clinical Site This link goes to an external web site



    Collapse Rotation Projects

    Potential Rotation Projects

    Project #1: Molecular Mechanisms in the Pathogenesis of Neurodegenerative Disease. The student can select projects emphasizing either molecular mechanisms of huntingtin in trafficking in neurons or receptor stimulated effects on gene expression in neurons. Techniques include:

    1. Generation of fusion proteins, raising antisera
    2. Preparation of organelles
    3. Immunocytochemistry, light microscopy and electron microscopy
    4. Immunoprecipitation methods
    5. PCR
    6. Protein separation techniques, gel electrophoresis, immunoblotting
    7. Autoradiography



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Haraszti RA, Roux L, Coles AH, Turanov AA, Alterman JF, Echeverria D, Godinho BMDC, Aronin N, Khvorova A. 5?-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo. Nucleic Acids Res. 2017 Jun 07. PMID: 28591791.
      View in: PubMed
    2. Nikan M, Osborn MF, Coles AH, Biscans A, Godinho BMDC, Haraszti RA, Sapp E, Echeverria D, DiFiglia M, Aronin N, Khvorova A. Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain. Bioconjug Chem. 2017 May 10. PMID: 28462988.
      View in: PubMed
    3. Pfister EL, Chase KO, Sun H, Kennington LA, Conroy F, Johnson E, Miller R, Borel F, Aronin N, Mueller C. Safe and Efficient Silencing with a Pol II, but Not a Pol lII, Promoter Expressing an Artificial miRNA Targeting Human Huntingtin. Mol Ther Nucleic Acids. 2017 Jun 16; 7:324-334. PMID: 28624208.
      View in: PubMed
    4. Haraszti RA, Didiot MC, Sapp E, Leszyk J, Shaffer SA, Rockwell HE, Gao F, Narain NR, DiFiglia M, Kiebish MA, Aronin N, Khvorova A. High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. J Extracell Vesicles. 2016; 5:32570. PMID: 27863537.
      View in: PubMed
    5. Keeler AM, Sapp E, Chase K, Sottosanti E, Danielson E, Pfister E, Stoica L, DiFiglia M, Aronin N, Sena-Esteves M. Cellular Analysis of Silencing the Huntington's Disease Gene Using AAV9 Mediated Delivery of Artificial Micro RNA into the Striatum of Q140/Q140 Mice. J Huntingtons Dis. 2016 Oct 1; 5(3):239-248. PMID: 27689620.
      View in: PubMed
    6. Vodicka P, Chase K, Iuliano M, Tousley A, Valentine DT, Sapp E, Kegel-Gleason KB, Sena-Esteves M, Aronin N, DiFiglia M. Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016 Oct 1; 5(3):249-260. PMID: 27689619.
      View in: PubMed
    7. Nikan M, Osborn MF, Coles AH, Godinho BM, Hall LM, Haraszti RA, Hassler MR, Echeverria D, Aronin N, Khvorova A. Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain. Mol Ther Nucleic Acids. 2016 Aug 09; 5(8):e344. PMID: 27504598.
      View in: PubMed
    8. Didiot MC, Hall LM, Coles AH, Haraszti RA, Godinho BM, Chase K, Sapp E, Ly S, Alterman JF, Hassler MR, Echeverria D, Raj L, Morrissey DV, DiFiglia M, Aronin N, Khvorova A. Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing. Mol Ther. 2016 Oct; 24(10):1836-1847. PMID: 27506293.
      View in: PubMed
    9. Vodicka P, Chase K, Iuliano M, Valentine DT, Sapp E, Lu B, Kegel-Gleason KB, Sena-Esteves M, Aronin N, DiFiglia M. Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016 Jun 13; 5(2):163-74. PMID: 27314618.
      View in: PubMed
    10. Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ. Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. Elife. 2016 Feb 24; 5:e10031. PMID: 26910012.
      View in: PubMed
    11. Liu W, Pfister EL, Kennington LA, Chase KO, Mueller C, DiFiglia M, Aronin N. Does the Mutant CAG Expansion in Huntingtin mRNA Interfere with Exonucleolytic Cleavage of its First Exon? J Huntingtons Dis. 2016; 5(1):33-8. PMID: 27003665.
      View in: PubMed
    12. Nikan M, Osborn MF, Coles AH, Godinho BM, Hall LM, Haraszti RA, Hassler MR, Echeverria D, Aronin N, Khvorova A. Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain. Mol Ther Nucleic Acids. 2016; 5:e344. PMID: 28131259.
      View in: PubMed
    13. Choudhury SR, Harris AF, Cabral DJ, Keeler AM, Sapp E, Ferreira JS, Gray-Edwards HL, Johnson JA, Johnson AK, Su Q, Stoica L, DiFiglia M, Aronin N, Martin DR, Gao G, Sena-Esteves M. Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector. Mol Ther. 2016 Apr; 24(4):726-35. PMID: 26708003.
      View in: PubMed
    14. Toledo RA, Qin Y, Cheng ZM, Gao Q, Iwata S, Silva GM, Prasad ML, Ocal IT, Rao S, Aronin N, Barontini M, Bruder J, Reddick RL, Chen Y, Aguiar RC, Dahia PL. Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas. Clin Cancer Res. 2016 May 1; 22(9):2301-10. PMID: 26700204.
      View in: PubMed
    15. Alterman JF, Hall LM, Coles AH, Hassler MR, Didiot MC, Chase K, Abraham J, Sottosanti E, Johnson E, Sapp E, Osborn MF, Difiglia M, Aronin N, Khvorova A. Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain. Mol Ther Nucleic Acids. 2015 Dec 01; 4:e266. PMID: 26623938.
      View in: PubMed
    16. Coles AH, Osborn MF, Alterman JF, Turanov AA, Godinho BM, Kennington L, Chase K, Aronin N, Khvorova A. A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo. Nucleic Acid Ther. 2016 Apr; 26(2):86-92. PMID: 26595721.
      View in: PubMed
    17. Vodicka P, Mo S, Tousley A, Green KM, Sapp E, Iuliano M, Sadri-Vakili G, Shaffer SA, Aronin N, DiFiglia M, Kegel-Gleason KB. Mass Spectrometry Analysis of Wild-Type and Knock-in Q140/Q140 Huntington's Disease Mouse Brains Reveals Changes in Glycerophospholipids Including Alterations in Phosphatidic Acid and Lyso-Phosphatidic Acid. J Huntingtons Dis. 2015; 4(2):187-201. PMID: 26397899.
      View in: PubMed
    18. Johnson E, Chase K, McGowan S, Mondo E, Pfister E, Mick E, Friedline RH, Kim JK, Sapp E, DiFiglia M, Aronin N. Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model. J Huntingtons Dis. 2015; 4(3):219-29. PMID: 26444021.
      View in: PubMed
    19. Zhu LJ, Holmes BR, Aronin N, Brodsky MH. CRISPRseek: a bioconductor package to identify target-specific guide RNAs for CRISPR-Cas9 genome-editing systems. PLoS One. 2014; 9(9):e108424. PMID: 25247697.
      View in: PubMed
    20. Aronin N, DiFiglia M. Huntingtin-lowering strategies in Huntington's disease: antisense oligonucleotides, small RNAs, and gene editing. Mov Disord. 2014 Sep 15; 29(11):1455-61. PMID: 25164989.
      View in: PubMed
    21. Evans MS, Chaurette JP, Adams ST, Reddy GR, Paley MA, Aronin N, Prescher JA, Miller SC. A synthetic luciferin improves bioluminescence imaging in live mice. Nat Methods. 2014 Apr; 11(4):393-5. PMID: 24509630.
      View in: PubMed
    22. Träger U, Andre R, Lahiri N, Magnusson-Lind A, Weiss A, Grueninger S, McKinnon C, Sirinathsinghji E, Kahlon S, Pfister EL, Moser R, Hummerich H, Antoniou M, Bates GP, Luthi-Carter R, Lowdell MW, Björkqvist M, Ostroff GR, Aronin N, Tabrizi SJ. HTT-lowering reverses Huntington's disease immune dysfunction caused by NF?B pathway dysregulation. Brain. 2014 Mar; 137(Pt 3):819-33. PMID: 24459107.
      View in: PubMed
    23. Vodicka P, Lim J, Williams DT, Kegel KB, Chase K, Park H, Marchionini D, Wilkinson S, Mead T, Birch H, Yates D, Lyons K, Dominguez C, Beconi M, Yue Z, Aronin N, DiFiglia M. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014; 3(2):159-74. PMID: 25062859.
      View in: PubMed
    24. van der Bom IM, Moser RP, Gao G, Mondo E, O'Connell D, Gounis MJ, McGowan S, Chaurette J, Bishop N, Sena-Esteves MS, Mueller C, Aronin N. Finding the striatum in sheep: use of a multi-modal guided approach for convection enhanced delivery. J Huntingtons Dis. 2013; 2(1):41-5. PMID: 25063428.
      View in: PubMed
    25. Valencia A, Sapp E, Kimm JS, McClory H, Ansong KA, Yohrling G, Kwak S, Kegel KB, Green KM, Shaffer SA, Aronin N, DiFiglia M. Striatal synaptosomes from Hdh140Q/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation. J Huntingtons Dis. 2013; 2(4):459-75. PMID: 24696705.
      View in: PubMed
    26. Liu W, Chaurette J, Pfister EL, Kennington LA, Chase KO, Bullock J, Vonsattel JP, Faull RL, Macdonald D, DiFiglia M, Zamore PD, Aronin N. Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain. J Huntingtons Dis. 2013; 2(4):491-500. PMID: 25062733.
      View in: PubMed
    27. Aronin N, Moore M. Hunting down huntingtin. N Engl J Med. 2012 Nov; 367(18):1753-4. PMID: 23113488.
      View in: PubMed
    28. Sapp E, Valencia A, Li X, Aronin N, Kegel KB, Vonsattel JP, Young AB, Wexler N, DiFiglia M. Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer. J Biol Chem. 2012 Apr 13; 287(16):13487-99. PMID: 22375012.
      View in: PubMed
    29. van der Bom IM, Moser RP, Gao G, Sena-Esteves M, Aronin N, Gounis MJ. Frameless multimodal image guidance of localized convection-enhanced delivery of therapeutics in the brain. J Neurointerv Surg. 2013 Jan 1; 5(1):69-72. PMID: 22193239.
      View in: PubMed
    30. Broderick JA, Salomon WE, Ryder SP, Aronin N, Zamore PD. Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing. RNA. 2011 Oct; 17(10):1858-69. PMID: 21878547.
      View in: PubMed
    31. Sah DW, Aronin N. Oligonucleotide therapeutic approaches for Huntington disease. J Clin Invest. 2011 Feb; 121(2):500-7. PMID: 21285523.
      View in: PubMed
    32. Kegel KB, Sapp E, Alexander J, Reeves P, Bleckmann D, Sobin L, Masso N, Valencia A, Jeong H, Krainc D, Palacino J, Curtis D, Kuhn R, Betschart C, Sena-Esteves M, Aronin N, Paganetti P, Difiglia M. Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors. Mol Neurodegener. 2010; 5:58. PMID: 21156064.
      View in: PubMed
    33. Li X, Valencia A, Sapp E, Masso N, Alexander J, Reeves P, Kegel KB, Aronin N, Difiglia M. Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease. J Neurosci. 2010 Mar 31; 30(13):4552-61. PMID: 20357106.
      View in: PubMed
    34. Qin Y, Yao L, King EE, Buddavarapu K, Lenci RE, Chocron ES, Lechleiter JD, Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G, Toledo RA, Toledo SP, Stiles C, Aguiar RC, Dahia PL. Germline mutations in TMEM127 confer susceptibility to pheochromocytoma. Nat Genet. 2010 Mar; 42(3):229-33. PMID: 20154675.
      View in: PubMed
    35. Valencia A, Reeves PB, Sapp E, Li X, Alexander J, Kegel KB, Chase K, Aronin N, DiFiglia M. Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease. J Neurosci Res. 2010 Jan; 88(1):179-90. PMID: 19642201.
      View in: PubMed
    36. Li X, Standley C, Sapp E, Valencia A, Qin ZH, Kegel KB, Yoder J, Comer-Tierney LA, Esteves M, Chase K, Alexander J, Masso N, Sobin L, Bellve K, Tuft R, Lifshitz L, Fogarty K, Aronin N, DiFiglia M. Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity. Mol Cell Biol. 2009 Nov; 29(22):6106-16. PMID: 19752198.
      View in: PubMed
    37. Li X, Sapp E, Chase K, Comer-Tierney LA, Masso N, Alexander J, Reeves P, Kegel KB, Valencia A, Esteves M, Aronin N, Difiglia M. Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease. Neurobiol Dis. 2009 Nov; 36(2):374-83. PMID: 19699304.
      View in: PubMed
    38. Kegel KB, Sapp E, Alexander J, Valencia A, Reeves P, Li X, Masso N, Sobin L, Aronin N, DiFiglia M. Polyglutamine expansion in huntingtin alters its interaction with phospholipids. J Neurochem. 2009 Sep; 110(5):1585-97. PMID: 19566678.
      View in: PubMed
    39. Aronin N. Expanded CAG repeats in the crosshairs. Nat Biotechnol. 2009 May; 27(5):451-2. PMID: 19430450.
      View in: PubMed
    40. Pfister EL, Kennington L, Straubhaar J, Wagh S, Liu W, DiFiglia M, Landwehrmeyer B, Vonsattel JP, Zamore PD, Aronin N. Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients. Curr Biol. 2009 May 12; 19(9):774-8. PMID: 19361997.
      View in: PubMed
    41. Li X, Sapp E, Valencia A, Kegel KB, Qin ZH, Alexander J, Masso N, Reeves P, Ritch JJ, Zeitlin S, Aronin N, Difiglia M. A function of huntingtin in guanine nucleotide exchange on Rab11. Neuroreport. 2008 Oct 29; 19(16):1643-7. PMID: 18845944.
      View in: PubMed
    42. Liu W, Kennington LA, Rosas HD, Hersch S, Cha JH, Zamore PD, Aronin N. Linking SNPs to CAG repeat length in Huntington's disease patients. Nat Methods. 2008 Nov; 5(11):951-3. PMID: 18931668.
      View in: PubMed
    43. DiFiglia M, Sena-Esteves M, Chase K, Sapp E, Pfister E, Sass M, Yoder J, Reeves P, Pandey RK, Rajeev KG, Manoharan M, Sah DW, Zamore PD, Aronin N. Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17204-9. PMID: 17940007.
      View in: PubMed
    44. Schwarz DS, Ding H, Kennington L, Moore JT, Schelter J, Burchard J, Linsley PS, Aronin N, Xu Z, Zamore PD. Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS Genet. 2006 Sep 8; 2(9):e140. PMID: 16965178.
      View in: PubMed
    45. Aronin N. Target selectivity in mRNA silencing. Gene Ther. 2006 Mar; 13(6):509-16. PMID: 16520821.
      View in: PubMed
    46. Kim YJ, Sapp E, Cuiffo BG, Sobin L, Yoder J, Kegel KB, Qin ZH, Detloff P, Aronin N, DiFiglia M. Lysosomal proteases are involved in generation of N-terminal huntingtin fragments. Neurobiol Dis. 2006 May; 22(2):346-56. PMID: 16423528.
      View in: PubMed
    47. Dahia PL, Hao K, Rogus J, Colin C, Pujana MA, Ross K, Magoffin D, Aronin N, Cascon A, Hayashida CY, Li C, Toledo SP, Stiles CD. Novel pheochromocytoma susceptibility loci identified by integrative genomics. Cancer Res. 2005 Nov 1; 65(21):9651-8. PMID: 16266984.
      View in: PubMed
    48. Schwartz WJ, Aronin N, Sassone-Corsi P. Photoinducible and rhythmic ICER-CREM immunoreactivity in the rat suprachiasmatic nucleus. Neurosci Lett. 2005 Sep 2; 385(1):87-91. PMID: 15936880.
      View in: PubMed
    49. Kegel KB, Sapp E, Yoder J, Cuiffo B, Sobin L, Kim YJ, Qin ZH, Hayden MR, Aronin N, Scott DL, Isenberg G, Goldmann WH, DiFiglia M. Huntingtin associates with acidic phospholipids at the plasma membrane. J Biol Chem. 2005 Oct 28; 280(43):36464-73. PMID: 16085648.
      View in: PubMed
    50. Ariano MA, Cepeda C, Calvert CR, Flores-Hernández J, Hernández-Echeagaray E, Klapstein GJ, Chandler SH, Aronin N, DiFiglia M, Levine MS. Striatal potassium channel dysfunction in Huntington's disease transgenic mice. J Neurophysiol. 2005 May; 93(5):2565-74. PMID: 15625098.
      View in: PubMed
    51. Qin ZH, Wang Y, Sapp E, Cuiffo B, Wanker E, Hayden MR, Kegel KB, Aronin N, DiFiglia M. Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction. J Neurosci. 2004 Jan 7; 24(1):269-81. PMID: 14715959.
      View in: PubMed
    52. Qin ZH, Wang Y, Kegel KB, Kazantsev A, Apostol BL, Thompson LM, Yoder J, Aronin N, DiFiglia M. Autophagy regulates the processing of amino terminal huntingtin fragments. Hum Mol Genet. 2003 Dec 15; 12(24):3231-44. PMID: 14570716.
      View in: PubMed
    53. Schwarz DS, Hutvágner G, Du T, Xu Z, Aronin N, Zamore PD. Asymmetry in the assembly of the RNAi enzyme complex. Cell. 2003 Oct 17; 115(2):199-208. PMID: 14567917.
      View in: PubMed
    54. Kim M, Roh JK, Yoon BW, Kang L, Kim YJ, Aronin N, DiFiglia M. Huntingtin is degraded to small fragments by calpain after ischemic injury. Exp Neurol. 2003 Sep; 183(1):109-15. PMID: 12957494.
      View in: PubMed
    55. Zamore PD, Aronin N. siRNAs knock down hepatitis. Nat Med. 2003 Mar; 9(3):266-7. PMID: 12612573.
      View in: PubMed
    56. Chan EY, Luthi-Carter R, Strand A, Solano SM, Hanson SA, DeJohn MM, Kooperberg C, Chase KO, DiFiglia M, Young AB, Leavitt BR, Cha JH, Aronin N, Hayden MR, Olson JM. Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease. Hum Mol Genet. 2002 Aug 15; 11(17):1939-51. PMID: 12165556.
      View in: PubMed
    57. Ariano MA, Aronin N, Difiglia M, Tagle DA, Sibley DR, Leavitt BR, Hayden MR, Levine MS. Striatal neurochemical changes in transgenic models of Huntington's disease. J Neurosci Res. 2002 Jun 15; 68(6):716-29. PMID: 12111832.
      View in: PubMed
    58. Petersén A, Chase K, Puschban Z, DiFiglia M, Brundin P, Aronin N. Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease. Exp Neurol. 2002 May; 175(1):297-300. PMID: 12009780.
      View in: PubMed
    59. Kegel KB, Meloni AR, Yi Y, Kim YJ, Doyle E, Cuiffo BG, Sapp E, Wang Y, Qin ZH, Chen JD, Nevins JR, Aronin N, DiFiglia M. Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription. J Biol Chem. 2002 Mar 1; 277(9):7466-76. PMID: 11739372.
      View in: PubMed
    60. Laforet GA, Sapp E, Chase K, McIntyre C, Boyce FM, Campbell M, Cadigan BA, Warzecki L, Tagle DA, Reddy PH, Cepeda C, Calvert CR, Jokel ES, Klapstein GJ, Ariano MA, Levine MS, DiFiglia M, Aronin N. Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease. J Neurosci. 2001 Dec 1; 21(23):9112-23. PMID: 11717344.
      View in: PubMed
    61. Kim YJ, Yi Y, Sapp E, Wang Y, Cuiffo B, Kegel KB, Qin ZH, Aronin N, DiFiglia M. Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12784-9. PMID: 11675509.
      View in: PubMed
    62. Sapp E, Kegel KB, Aronin N, Hashikawa T, Uchiyama Y, Tohyama K, Bhide PG, Vonsattel JP, DiFiglia M. Early and progressive accumulation of reactive microglia in the Huntington disease brain. J Neuropathol Exp Neurol. 2001 Feb; 60(2):161-72. PMID: 11273004.
      View in: PubMed
    63. Qin ZH, Wang Y, Kikly KK, Sapp E, Kegel KB, Aronin N, DiFiglia M. Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation. J Biol Chem. 2001 Mar 16; 276(11):8079-86. PMID: 11102441.
      View in: PubMed
    64. Kegel KB, Kim M, Sapp E, McIntyre C, Castaño JG, Aronin N, DiFiglia M. Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. J Neurosci. 2000 Oct 1; 20(19):7268-78. PMID: 11007884.
      View in: PubMed
    65. Schwartz WJ, Carpino A, de la Iglesia HO, Baler R, Klein DC, Nakabeppu Y, Aronin N. Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus. Neuroscience. 2000; 98(3):535-47. PMID: 10869847.
      View in: PubMed
    66. Aronin N, Kim M, Laforet G, DiFiglia M. Are there multiple pathways in the pathogenesis of Huntington's disease? Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29; 354(1386):995-1003. PMID: 10434298.
      View in: PubMed
    67. Sapp E, Penney J, Young A, Aronin N, Vonsattel JP, DiFiglia M. Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease. J Neuropathol Exp Neurol. 1999 Feb; 58(2):165-73. PMID: 10029099.
      View in: PubMed
    68. Kim M, Lee HS, LaForet G, McIntyre C, Martin EJ, Chang P, Kim TW, Williams M, Reddy PH, Tagle D, Boyce FM, Won L, Heller A, Aronin N, DiFiglia M. Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition. J Neurosci. 1999 Feb 1; 19(3):964-73. PMID: 9920660.
      View in: PubMed
    69. Martin EJ, Kim M, Velier J, Sapp E, Lee HS, Laforet G, Won L, Chase K, Bhide PG, Heller A, Aronin N, Difiglia M. Analysis of Huntingtin-associated protein 1 in mouse brain and immortalized striatal neurons. J Comp Neurol. 1999 Jan 25; 403(4):421-30. PMID: 9888310.
      View in: PubMed
    70. Kim M, Velier J, Chase K, Laforet G, Kalchman MA, Hayden MR, Won L, Heller A, Aronin N, Difiglia M. Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin. Neuroscience. 1999; 89(4):1159-67. PMID: 10362304.
      View in: PubMed
    71. Velier J, Kim M, Schwarz C, Kim TW, Sapp E, Chase K, Aronin N, DiFiglia M. Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways. Exp Neurol. 1998 Jul; 152(1):34-40. PMID: 9682010.
      View in: PubMed
    72. Davies SW, Beardsall K, Turmaine M, DiFiglia M, Aronin N, Bates GP. Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions? Lancet. 1998 Jan 10; 351(9096):131-3. PMID: 9439509.
      View in: PubMed
    73. Sapp E, Schwarz C, Chase K, Bhide PG, Young AB, Penney J, Vonsattel JP, Aronin N, DiFiglia M. Huntingtin localization in brains of normal and Huntington's disease patients. Ann Neurol. 1997 Oct; 42(4):604-12. PMID: 9382472.
      View in: PubMed
    74. DiFiglia M, Sapp E, Chase KO, Davies SW, Bates GP, Vonsattel JP, Aronin N. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science. 1997 Sep 26; 277(5334):1990-3. PMID: 9302293.
      View in: PubMed
    75. Block-Galarza J, Chase KO, Sapp E, Vaughn KT, Vallee RB, DiFiglia M, Aronin N. Fast transport and retrograde movement of huntingtin and HAP 1 in axons. Neuroreport. 1997 Jul 7; 8(9-10):2247-51. PMID: 9243620.
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    76. Melloni RH, Aronin N, DeGennaro LJ, Ferris CF, Harrison RJ. Dde-I restriction endonuclease fragmentation: a novel method of generating cDNA probes for in situ hybridization in brain. J Histochem Cytochem. 1997 May; 45(5):755-63. PMID: 9154163.
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    77. Stock JL, Warth MR, Teh BT, Coderre JA, Overdorf JH, Baumann G, Hintz RL, Hartman ML, Seizinger BR, Larsson C, Aronin N. A kindred with a variant of multiple endocrine neoplasia type 1 demonstrating frequent expression of pituitary tumors but not linked to the multiple endocrine neoplasia type 1 locus at chromosome region 11q13. J Clin Endocrinol Metab. 1997 Feb; 82(2):486-92. PMID: 9024241.
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    78. Bennett MR, Aronin N, Schwartz WJ. In vitro stimulation of c-Fos protein expression in the suprachiasmatic nucleus of hypothalamic slices. Brain Res Mol Brain Res. 1996 Nov; 42(1):140-4. PMID: 8915592.
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    79. Bhide PG, Day M, Sapp E, Schwarz C, Sheth A, Kim J, Young AB, Penney J, Golden J, Aronin N, DiFiglia M. Expression of normal and mutant huntingtin in the developing brain. J Neurosci. 1996 Sep 1; 16(17):5523-35. PMID: 8757264.
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    80. Peters RV, Aronin N, Schwartz WJ. c-Fos expression in the rat intergeniculate leaflet: photic regulation, co-localization with Fos-B, and cellular identification. Brain Res. 1996 Jul 29; 728(2):231-41. PMID: 8864487.
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    81. Schwartz WJ, Peters RV, Aronin N, Bennett MR. Unexpected c-fos gene expression in the suprachiasmatic nucleus of mice entrained to a skeleton photoperiod. J Biol Rhythms. 1996 Mar; 11(1):35-44. PMID: 8695890.
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    82. Mello CJ, Veronikis I, Fraire AE, Aronin N, Irwin RS, Braverman LE. Metastatic papillary thyroid carcinoma to lung diagnosed by bronchoalveolar lavage. J Clin Endocrinol Metab. 1996 Jan; 81(1):406-10. PMID: 8550785.
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    83. Aronin N, Chase K, Young C, Sapp E, Schwarz C, Matta N, Kornreich R, Landwehrmeyer B, Bird E, Beal MF, et al. CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain. Neuron. 1995 Nov; 15(5):1193-201. PMID: 7576661.
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    84. Birnbaum MJ, Wright KL, van Wijnen AJ, Ramsey-Ewing AL, Bourke MT, Last TJ, Aziz F, Frenkel B, Rao BR, Aronin N, et al. Functional role for Sp1 in the transcriptional amplification of a cell cycle regulated histone H4 gene. Biochemistry. 1995 Jun 13; 34(23):7648-58. PMID: 7779811.
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    85. Peters RV, Aronin N, Schwartz WJ. Circadian regulation of Fos B is different from c-Fos in the rat suprachiasmatic nucleus. Brain Res Mol Brain Res. 1994 Dec; 27(2):243-8. PMID: 7898307.
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    86. Schwartz WJ, Takeuchi J, Shannon W, Davis EM, Aronin N. Temporal regulation of light-induced Fos and Fos-like protein expression in the ventrolateral subdivision of the rat suprachiasmatic nucleus. Neuroscience. 1994 Feb; 58(3):573-83. PMID: 8170538.
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    87. Takeuchi J, Shannon W, Aronin N, Schwartz WJ. Compositional changes of AP-1 DNA-binding proteins are regulated by light in a mammalian circadian clock. Neuron. 1993 Nov; 11(5):825-36. PMID: 8240806.
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    88. Lester J, Fink S, Aronin N, DiFiglia M. Colocalization of D1 and D2 dopamine receptor mRNAs in striatal neurons. Brain Res. 1993 Sep 3; 621(1):106-10. PMID: 8221060.
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    89. Lacomis D, Chad DA, Aronin N, Smith TW. The myopathy of Cushing's syndrome. Muscle Nerve. 1993 Aug; 16(8):880-1. PMID: 8332144.
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    90. Huang Q, Zhou D, Chase K, Gusella JF, Aronin N, DiFiglia M. Immunohistochemical localization of the D1 dopamine receptor in rat brain reveals its axonal transport, pre- and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus. Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):11988-92. PMID: 1281547.
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    91. Aronin N, DiFiglia M. The subcellular localization of the G-protein Gi alpha in the basal ganglia reveals its potential role in both signal transduction and vesicle trafficking. J Neurosci. 1992 Sep; 12(9):3435-44. PMID: 1527588.
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    92. Gerbaulet SP, van Wijnen AJ, Aronin N, Tassinari MS, Lian JB, Stein JL, Stein GS. Downregulation of histone H4 gene transcription during postnatal development in transgenic mice and at the onset of differentiation in transgenically derived calvarial osteoblast cultures. J Cell Biochem. 1992 Jun; 49(2):137-47. PMID: 1400621.
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    93. Bouckoms AJ, Sweet WH, Poletti C, Lavori P, Carr D, Matson W, Gamache P, Aronin N. Monoamines in the brain cerebrospinal fluid of facial pain patients. Anesth Prog. 1992; 39(6):201-8. PMID: 7504420.
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    94. Aronin N, Chase K, Folsom R, Christakos S, DiFiglia M. Immunoreactive calcium-binding protein (calbindin-D28k) in interneurons and trigeminothalamic neurons of the rat nucleus caudalis localized with peroxidase and immunogold methods. Synapse. 1991 Feb; 7(2):106-13. PMID: 1707189.
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    95. Chipkin SR, Gottlieb P, Lundstrom R, Leppo J, Aronin N. Transient myocardial perfusion abnormalities in diabetic patients: a prospective study using thallium exercise tolerance testing. Cardiology. 1991; 79(3):172-9. PMID: 1769034.
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    96. Aronin N, Chase K, Sagar SM, Sharp FR, DiFiglia M. N-methyl-D-aspartate receptor activation in the neostriatum increases c-fos and fos-related antigens selectively in medium-sized neurons. Neuroscience. 1991; 44(2):409-20. PMID: 1834961.
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    97. Owen TA, Bortell R, Yocum SA, Smock SL, Zhang M, Abate C, Shalhoub V, Aronin N, Wright KL, van Wijnen AJ, et al. Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription. Proc Natl Acad Sci U S A. 1990 Dec; 87(24):9990-4. PMID: 2124710.
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    98. Chad DA, Aronin N, Lundstrom R, McKeon P, Ross D, Molitch M, Schipper HM, Stall G, Dyess E, Tarsy D. Does capsaicin relieve the pain of diabetic neuropathy? Pain. 1990 Sep; 42(3):387-8. PMID: 1701234.
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    99. Aronin N, Sagar SM, Sharp FR, Schwartz WJ. Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei. Proc Natl Acad Sci U S A. 1990 Aug; 87(15):5959-62. PMID: 2116012.
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    100. Madras BK, Canfield DR, Pfaelzer C, Vittimberga FJ, Difiglia M, Aronin N, Bakthavachalam V, Baindur N, Neumeyer JL. Fluorescent and biotin probes for dopamine receptors: D1 and D2 receptor affinity and selectivity. Mol Pharmacol. 1990 Jun; 37(6):833-9. PMID: 2141665.
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    101. DiFiglia M, Aronin N. Synaptic interactions between GABAergic neurons and trigeminothalamic cells in the rat trigeminal nucleus caudalis. Synapse. 1990; 6(4):358-63. PMID: 1705057.
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    102. Alpert JS, Chipkin SR, Aronin N. Diabetes mellitus and silent myocardial ischemia. Adv Cardiol. 1990; 37:297-303. PMID: 2220457.
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    103. DiFiglia M, Christakos S, Aronin N. Ultrastructural localization of immunoreactive calbindin-D28k in the rat and monkey basal ganglia, including subcellular distribution with colloidal gold labeling. J Comp Neurol. 1989 Jan 22; 279(4):653-65. PMID: 2918090.
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    104. Aronin N, Coslovsky R, Chase K. Hypothyroidism increases substance P concentrations in the heterotopic anterior pituitary. Endocrinology. 1988 Jun; 122(6):2911-4. PMID: 2453352.
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    105. Chipkin SR, Stoff JS, Aronin N. Immunohistochemical evidence for neural mediation of VIP activity in the dogfish rectal gland. Peptides. 1988 Jan-Feb; 9(1):119-24. PMID: 3362739.
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    106. Aronin N, Leeman SE, Clements RS. Diminished flare response in neuropathic diabetic patients. Comparison of effects of substance P, histamine, and capsaicin. Diabetes. 1987 Oct; 36(10):1139-43. PMID: 2443407.
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    107. Rafols JA, Aronin N, Difiglia M. A Golgi study of the monkey paraventricular nucleus: neuronal types, afferent and efferent fibers. J Comp Neurol. 1987 Mar 22; 257(4):595-613. PMID: 2447130.
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    108. Chipkin SR, Frid D, Alpert JS, Baker SP, Dalen JE, Aronin N. Frequency of painless myocardial ischemia during exercise tolerance testing in patients with and without diabetes mellitus. Am J Cardiol. 1987 Jan 1; 59(1):61-5. PMID: 3812254.
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    109. Aronin N, Chase K, DiFiglia M. Glutamic acid decarboxylase and enkephalin immunoreactive axon terminals in the rat neostriatum synapse with striatonigral neurons. Brain Res. 1986 Feb 12; 365(1):151-8. PMID: 3512036.
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    110. Aronin N, Coslovsky R, Leeman SE. Substance P and neurotensin: their roles in the regulation of anterior pituitary function. Annu Rev Physiol. 1986; 48:537-49. PMID: 2423025.
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    111. Coslovsky R, Braverman LE, Leeman SE, Aronin N. The differential effects of thyroid and gonadal hormones on substance P content in the anterior pituitary of the prepubertal rat. Endocrinology. 1985 Nov; 117(5):2198-202. PMID: 2412805.
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    112. Coslovsky R, Evans RW, Leeman SE, Braverman LE, Aronin N. The effects of gonadal steroids on the content of substance P in the rat anterior pituitary. Endocrinology. 1984 Dec; 115(6):2285-9. PMID: 6209122.
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    113. DiFiglia M, Aronin N. Quantitative electron microscopic study of immunoreactive somatostatin axons in the rat neostriatum. Neurosci Lett. 1984 Sep 7; 50(1-3):325-31. PMID: 6149504.
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    114. Martino E, Safran M, Aghini-Lombardi F, Rajatanavin R, Lenziardi M, Fay M, Pacchiarotti A, Aronin N, Macchia E, Haffajee C, et al. Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy. Ann Intern Med. 1984 Jul; 101(1):28-34. PMID: 6428291.
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    115. Aronin N, Morency K, Leeman SE, Braverman LE, Coslovsky R. Regulation by thyroid hormone of the concentration of substance P in the rat anterior pituitary. Endocrinology. 1984 Jun; 114(6):2138-42. PMID: 6202496.
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    116. Aronin N, Difiglia M, Graveland GA, Schwartz WJ, Wu JY. Localization of immunoreactive enkephalins in GABA synthesizing neurons of the rat neostriatum. Brain Res. 1984 May 23; 300(2):376-80. PMID: 6375810.
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    117. DiFiglia M, Aronin N. Immunoreactive leu-enkephalin in the monkey hypothalamus including observations on its ultrastructural localization in the paraventricular nucleus. J Comp Neurol. 1984 May 20; 225(3):313-26. PMID: 6144702.
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    118. Difiglia M, Aronin N, Leeman SE. Ultrastructural localization of immunoreactive neurotensin in the monkey superficial dorsal horn. J Comp Neurol. 1984 May 1; 225(1):1-12. PMID: 6373845.
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    119. Maciewicz R, Phipps BS, Foote WE, Aronin N, DiFiglia M. The distribution of substance P-containing neurons in the cat Edinger-Westphal nucleus: relationship to efferent projection systems. Brain Res. 1983 Jul 4; 270(2):217-30. PMID: 6192874.
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    120. Aronin N, Cooper PE, Lorenz LJ, Bird ED, Sagar SM, Leeman SE, Martin JB. Somatostatin is increased in the basal ganglia in Huntington disease. Ann Neurol. 1983 May; 13(5):519-26. PMID: 6191621.
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    121. Aronin N, Krieger DT. Plasma immunoreactive beta-endorphin is elevated in uraemia. Clin Endocrinol (Oxf). 1983 May; 18(5):459-64. PMID: 6307552.
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    122. DiFiglia M, Aronin N. Ultrastructural features of immunoreactive somatostatin neurons in the rat caudate nucleus. J Neurosci. 1982 Sep; 2(9):1267-74. PMID: 6126530.
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    123. Aronin N, Carraway RE, Ferris CF, Hammer RA, Leeman SE. The stability and metabolism of intravenously administered neurotensin in the rat. Peptides. 1982 Jul-Aug; 3(4):637-42. PMID: 7134032.
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    124. DiFiglia M, Aronin N, Leeman SE. Light microscopic and ultrastructural localization of immunoreactive substance P in the dorsal horn of monkey spinal cord. Neuroscience. 1982 May; 7(5):1127-39. PMID: 6180349.
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    125. Bybee DE, Wiesen M, Aronin N, Krieger DT, Frohman LA, Kopin IJ. Failure of bromocriptine to lower plasma catecholamines in normal men and women. J Clin Endocrinol Metab. 1982 Mar; 54(3):648-50. PMID: 6276434.
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    126. DiFiglia M, Aronin N, Martin JB. Light and electron microscopic localization of immunoreactive Leu-enkephalin in the monkey basal ganglia. J Neurosci. 1982 Mar; 2(3):303-20. PMID: 6121017.
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    127. DiFiglia M, Aronin N, Leeman SE. Immunoreactive substance P in the substantia nigra of the monkey: light and electron microscopic localization. Brain Res. 1982 Feb 11; 233(2):381-8. PMID: 6174178.
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    128. Leeman SE, Aronin N, Ferris C. Substance P and neurotensin. Recent Prog Horm Res. 1982; 38:93-132. PMID: 6181544.
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    129. Aronin N, Liotta AS, Shickmanter B, Schussler GC, Krieger DT. Impaired clearance of beta-lipotropin in uremia. J Clin Endocrinol Metab. 1981 Oct; 53(4):797-800. PMID: 6270175.
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    130. Aronin N, Wiesen M, Liotta AS, Schussler GC, Krieger DT. Comparative metabolic clearance rates of beta-endorphin and beta-lipotropin in humans. Life Sci. 1981 Sep 21; 29(12):1265-9. PMID: 6272041.
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    131. Aronin N, DiFiglia M, Liotta AS, Martin JB. Ultrastructural localization and biochemical features of immunoreactive LEU-enkephalin in monkey dorsal horn. J Neurosci. 1981 Jun; 1(6):561-77. PMID: 6286896.
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    132. Mahony C, Hindman MC, Aronin N, Wagner GS. Prognostic differences in subgroups of patients with electrographic evidence of subendocardial or transmural myocardial infarction. The favorable outlook for patients with an initially normal QRS complex. Am J Med. 1980 Aug; 69(2):183-6. PMID: 7405943.
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    133. Aronin N, Krieger DT. Sustained remission of Nelson's syndrome after stopping cyproheptadine treatment. N Engl J Med. 1980 Feb 21; 302(8):453-5. PMID: 6243392.
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