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John Mark Madison MD

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionPulmonary Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPopulation Health Sciences

    Collapse Biography 
    Collapse education and training
    Carleton College, Northfield, MN, United StatesBABiology
    Harvard Medical School, Boston, MA, United StatesMD

    Collapse Overview 
    Collapse overview

    Scientific interests

    • Calcium signaling in airway smooth muscle cells.
    • Adrenergic signaling in airway smooth muscle cells
    • Lung imaging

    Research activities

    Calcium signaling in airway smooth muscle cells. Contraction of airway smooth muscle, an important cause of airway obstruction in asthma, is initiated by the rapid release of calcium ions from calcium stores of the sarcoplasmic reticulum. Using calcium dyes and laser-based imaging of single cells, our recent work has focused on the observation that interleukin-4 (IL-4) releases calcium from the sarcoplasmic reticulum. We aim to understand the mechanisms underlying this effect of IL-4 on calcium signaling and the functional consequences this has on cell contractility.

    Other Titles

    Division Chief, Pulmonary, Allergy and Critical Care Medicine
    Medical Director, Pulmonary Diagnostic Laboratories


    Medical School: Harvard Medical School, 1975-79
    Medical Residency:Washington University, Barnes Hospital, 1979-82
    Pulmonary Fellowship: UCSF, 1982-85


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Irwin RS, Madison JM. Gefapixant for Refractory or Unexplained Chronic Cough? JAMA. 2023 10 10; 330(14):1335-1336. PMID: 37694857.
      Citations:    Fields:    Translation:Humans
    2. Irwin RS, Madison JM. Managing Chronic Cough Associated with Idiopathic Pulmonary Fibrosis - Will Nalbuphine Fill an Unmet Need? NEJM Evid. 2023 Aug; 2(8):EVIDe2300126. PMID: 38320149.
    3. Madison JM, Irwin RS. Chronic Cough and COPD. Chest. 2020 06; 157(6):1399-1400. PMID: 32505298.
      Citations: 1     Fields:    Translation:Humans
    4. Madison JM, French CL. Giants in Chest Medicine: Richard S.?Irwin, MD, Master?FCCP. Chest. 2020 06; 157(6):1423-1425. PMID: 32505310.
      Citations:    Fields:    Translation:Humans
    5. Irwin RS, French CL, Madison JM. Managing unexplained chronic cough in adults: what are the unmet needs? Lancet Respir Med. 2020 08; 8(8):745-747. PMID: 32109424.
      Citations: 2     Fields:    Translation:Humans
    6. Nguyen HB, Thomson C, Jarjour NN, Dixon AE, Liesching TN, Schnapp LM, Madison JM, Murin S, Glenny R, Kaminski N. Leading Change and Negotiation Strategies for Division Leaders in Clinical Medicine. Chest. 2019 12; 156(6):1246-1253. PMID: 31299244.
      Citations: 4     Fields:    
    7. Pbert L, Madison JM, Druker S, Olendzki N, Magner R, Reed G, Allison J, Carmody J. Effect of mindfulness training on asthma quality of life and lung function: a randomised controlled trial. Thorax. 2012 Sep; 67(9):769-76. PMID: 22544892.
      Citations: 43     Fields:    Translation:Humans
    8. Madison JM, Irwin RS. Cough: a worldwide problem. Otolaryngol Clin North Am. 2010 Feb; 43(1):1-13, vii. PMID: 20172252.
      Citations: 6     Fields:    Translation:Humans
    9. Nunes FP, Bishop T, Prasad ML, Madison JM, Kim DY. Laryngeal candidiasis mimicking malignancy. Laryngoscope. 2008 Nov; 118(11):1957-9. PMID: 18978482.
      Citations: 6     Fields:    Translation:HumansAnimals
    10. Martin G, O'Connell RJ, Pietrzykowski AZ, Treistman SN, Ethier MF, Madison JM. Interleukin-4 activates large-conductance, calcium-activated potassium (BKCa) channels in human airway smooth muscle cells. Exp Physiol. 2008 Jul; 93(7):908-18. PMID: 18403443.
      Citations: 7     Fields:    Translation:HumansCells
    11. Madison JM. Hypersensitivity pneumonitis: clinical perspectives. Arch Pathol Lab Med. 2008 Feb; 132(2):195-8. PMID: 18251575.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    12. Ethier MF, Madison JM. Adenosine A1 receptors mediate mobilization of calcium in human bronchial smooth muscle cells. Am J Respir Cell Mol Biol. 2006 Oct; 35(4):496-502. PMID: 16709961.
      Citations: 26     Fields:    Translation:HumansCells
    13. Ethier MF, Madison JM. IL-4 inhibits calcium transients in bovine trachealis cells by a ryanodine receptor-dependent mechanism. FASEB J. 2006 Jan; 20(1):154-6. PMID: 16280365.
      Citations: 1     Fields:    Translation:AnimalsCells
    14. Madison JM, Irwin RS. Chronic cough in adults with interstitial lung disease. Curr Opin Pulm Med. 2005 Sep; 11(5):412-6. PMID: 16093815.
      Citations: 17     Fields:    Translation:Humans
    15. Smyrnios NA, Schaefer OP, Collins RM, Madison JM. Applicability of prediction rules in patients with community-acquired pneumonia requiring intensive care: a pilot study. J Intensive Care Med. 2005 Jul-Aug; 20(4):226-32. PMID: 16061905.
      Citations: 1     Fields:    Translation:Humans
    16. Ethier MF, Cappelluti E, Madison JM. Mechanisms of interleukin-4 effects on calcium signaling in airway smooth muscle cells. J Pharmacol Exp Ther. 2005 Apr; 313(1):127-33. PMID: 15634940.
      Citations: 4     Fields:    Translation:AnimalsCells
    17. Madison JM. Migration of airway smooth muscle cells. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):8-11. PMID: 12821446.
      Citations: 15     Fields:    Translation:HumansCells
    18. Madison JM, Irwin RS. Pharmacotherapy of chronic cough in adults. Expert Opin Pharmacother. 2003 Jul; 4(7):1039-48. PMID: 12831332.
      Citations: 4     Fields:    Translation:Humans
    19. Ethier MF, Madison JM. LY294002, but not wortmannin, increases intracellular calcium and inhibits calcium transients in bovine and human airway smooth muscle cells. Cell Calcium. 2002 Jul; 32(1):31-8. PMID: 12127060.
      Citations: 14     Fields:    Translation:HumansAnimals
    20. Irwin RS, Madison JM. Diagnosis and treatment of chronic cough due to gastro-esophageal reflux disease and postnasal drip syndrome. Pulm Pharmacol Ther. 2002; 15(3):261-6. PMID: 12099775.
      Citations: 20     Fields:    Translation:Humans
    21. Mitra P, De A, Ethier MF, Mimori K, Kodys K, Shibuta K, Mori M, Madison JM, Miller-Graziano C, Barnard GF. Loss of chemokine SDF-1alpha-mediated CXCR4 signalling and receptor internalization in human hepatoma cell line HepG2. Cell Signal. 2001 May; 13(5):311-9. PMID: 11369512.
      Citations: 13     Fields:    Translation:HumansCells
    22. Irwin RS, Madison JM. Symptom research on chronic cough: a historical perspective. Ann Intern Med. 2001 May 01; 134(9 Pt 2):809-14. PMID: 11346315.
      Citations: 2     Fields:    Translation:Humans
    23. Irwin RS, Madison JM. The diagnosis and treatment of cough. N Engl J Med. 2000 Dec 07; 343(23):1715-21. PMID: 11106722.
      Citations: 74     Fields:    Translation:Humans
    24. Ethier MF, Dextradeur T, Schaefer OP, Madison JM. Effects of salmeterol on muscarinic inhibition of adenylyl cyclase in bovine trachealis cells. Life Sci. 2000 Oct 20; 67(22):2753-8. PMID: 11105991.
      Citations: 1     Fields:    Translation:Animals
    25. Irwin RS, Madison JM. Anatomical diagnostic protocol in evaluating chronic cough with specific reference to gastroesophageal reflux disease. Am J Med. 2000 Mar 06; 108 Suppl 4a:126S-130S. PMID: 10718465.
      Citations: 13     Fields:    Translation:Humans
    26. Irwin RS, Madison JM, Fraire AE. The cough reflex and its relation to gastroesophageal reflux. Am J Med. 2000 Mar 06; 108 Suppl 4a:73S-78S. PMID: 10718456.
      Citations: 7     Fields:    Translation:Humans
    27. Madison JM, Ethier MF, Yamaguchi H. Refilling of caffeine-sensitive intracellular calcium stores in bovine airway smooth muscle cells. Am J Physiol. 1998 11; 275(5):L852-60. PMID: 9815101.
      Citations: 4     Fields:    Translation:AnimalsCells
    28. Madison JM, Irwin RS. Chronic obstructive pulmonary disease. Lancet. 1998 Aug 08; 352(9126):467-73. PMID: 9708769.
      Citations: 18     Fields:    Translation:Humans
    29. Madison JM, Yamaguchi H. Muscarinic inhibition of adenylyl cyclase regulates intracellular calcium in single airway smooth muscle cells. Am J Physiol. 1996 Feb; 270(2 Pt 1):L208-14. PMID: 8779989.
      Citations: 1     Fields:    Translation:AnimalsCells
    30. Ethier MF, Schaefer OP, Samant N, Yamaguchi H, Madison JM. Muscarinic receptor reserve for inhibition of cAMP accumulation in bovine trachealis cells. Am J Physiol. 1996 Feb; 270(2 Pt 1):L199-207. PMID: 8779988.
      Citations: 4     Fields:    Translation:Animals
    31. Schaefer OP, Ethier MF, Madison JM. Muscarinic regulation of cyclic AMP in bovine trachealis cells. Am J Respir Cell Mol Biol. 1995 Aug; 13(2):217-26. PMID: 7626289.
      Citations: 2     Fields:    Translation:AnimalsCells
    32. Yamaguchi H, Kajita J, Madison JM. Isoproterenol increases peripheral [Ca2+]i and decreases inner [Ca2+]i in single airway smooth muscle cells. Am J Physiol. 1995 Mar; 268(3 Pt 1):C771-9. PMID: 7900780.
      Citations: 13     Fields:    Translation:AnimalsCells
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