John Mark Madison MD
Title | Professor |
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Institution | University of Massachusetts Medical School |
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Department | Medicine |
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Address | University of Massachusetts Medical School 55 Lake Avenue North Worcester MA 01655
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Phone | 508-856-6938 |
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vCard | Download vCard |
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Institution | UMMS - School of Medicine |
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Department | Medicine |
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Division | Pulmonary, Allergy And Critical Care Medicine |
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Institution | UMMS - School of Medicine |
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Department | Microbiology and Physiological Systems |
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Institution | UMMS - Graduate School of Biomedical Sciences |
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Department | Masters in Clinical Investigation |
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Biography Carleton College, Northfield, MN, United States | BA | | Biology | Harvard Medical School, Boston, MA, United States | MD | | |
Overview Scientific interestsResearch activitiesCalcium signaling in airway smooth muscle cells. Contraction of airway smooth muscle, an important cause of airway obstruction in asthma, is initiated by the rapid release of calcium ions from calcium stores of the sarcoplasmic reticulum. Using calcium dyes and laser-based imaging of single cells, our recent work has focused on the observation that interleukin-4 (IL-4) releases calcium from the sarcoplasmic reticulum. We aim to understand the mechanisms underlying this effect of IL-4 on calcium signaling and the functional consequences this has on cell contractility.
Other TitlesDivision Chief, Pulmonary, Allergy and Critical Care Medicine Medical Director, Pulmonary Diagnostic Laboratories EducationMedical School: Harvard Medical School, 1975-79 Medical Residency:Washington University, Barnes Hospital, 1979-82 Pulmonary Fellowship: UCSF, 1982-85 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Nguyen HB, Thomson C, Jarjour NN, Dixon AE, Liesching TN, Schnapp LM, Madison JM, Murin S, Glenny R, Kaminski N. Leading Change and Negotiation Strategies for Division Leaders in Clinical Medicine. Chest. 2019 Jul 09. PMID: 31299244.
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Pbert L, Madison JM, Druker S, Olendzki N, Magner R, Reed G, Allison J, Carmody J. Effect of mindfulness training on asthma quality of life and lung function: a randomised controlled trial. Thorax. 2012 Sep; 67(9):769-76. PMID: 22544892.
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Madison JM, Irwin RS. Cough: a worldwide problem. Otolaryngol Clin North Am. 2010 Feb; 43(1):1-13, vii. PMID: 20172252.
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Nunes FP, Bishop T, Prasad ML, Madison JM, Kim DY. Laryngeal candidiasis mimicking malignancy. Laryngoscope. 2008 Nov; 118(11):1957-9. PMID: 18978482.
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Martin G, O'Connell RJ, Pietrzykowski AZ, Treistman SN, Ethier MF, Madison JM. Interleukin-4 activates large-conductance, calcium-activated potassium (BKCa) channels in human airway smooth muscle cells. Exp Physiol. 2008 Jul; 93(7):908-18. PMID: 18403443.
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Madison JM. Hypersensitivity pneumonitis: clinical perspectives. Arch Pathol Lab Med. 2008 Feb; 132(2):195-8. PMID: 18251575.
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Ethier MF, Madison JM. Adenosine A1 receptors mediate mobilization of calcium in human bronchial smooth muscle cells. Am J Respir Cell Mol Biol. 2006 Oct; 35(4):496-502. PMID: 16709961.
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Ethier MF, Madison JM. IL-4 inhibits calcium transients in bovine trachealis cells by a ryanodine receptor-dependent mechanism. FASEB J. 2006 Jan; 20(1):154-6. PMID: 16280365.
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Madison JM, Irwin RS. Chronic cough in adults with interstitial lung disease. Curr Opin Pulm Med. 2005 Sep; 11(5):412-6. PMID: 16093815.
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Smyrnios NA, Schaefer OP, Collins RM, Madison JM. Applicability of prediction rules in patients with community-acquired pneumonia requiring intensive care: a pilot study. J Intensive Care Med. 2005 Jul-Aug; 20(4):226-32. PMID: 16061905.
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Ethier MF, Cappelluti E, Madison JM. Mechanisms of interleukin-4 effects on calcium signaling in airway smooth muscle cells. J Pharmacol Exp Ther. 2005 Apr; 313(1):127-33. PMID: 15634940.
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Madison JM. Migration of airway smooth muscle cells. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):8-11. PMID: 12821446.
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Madison JM, Irwin RS. Pharmacotherapy of chronic cough in adults. Expert Opin Pharmacother. 2003 Jul; 4(7):1039-48. PMID: 12831332.
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Ethier MF, Madison JM. LY294002, but not wortmannin, increases intracellular calcium and inhibits calcium transients in bovine and human airway smooth muscle cells. Cell Calcium. 2002 Jul; 32(1):31-8. PMID: 12127060.
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Irwin RS, Madison JM. The persistently troublesome cough. Am J Respir Crit Care Med. 2002 Jun 1; 165(11):1469-74. PMID: 12045118.
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Irwin RS, Madison JM. Diagnosis and treatment of chronic cough due to gastro-esophageal reflux disease and postnasal drip syndrome. Pulm Pharmacol Ther. 2002; 15(3):261-6. PMID: 12099775.
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Madison JM, Ethier MF. Interleukin-4 rapidly inhibits calcium transients in response to carbachol in bovine airway smooth muscle cells. Am J Respir Cell Mol Biol. 2001 Aug; 25(2):239-44. PMID: 11509335.
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Ethier MF, Yamaguchi H, Madison JM. Effects of cyclopiazonic acid on cytosolic calcium in bovine airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2001 Jul; 281(1):L126-33. PMID: 11404255.
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Mitra P, De A, Ethier MF, Mimori K, Kodys K, Shibuta K, Mori M, Madison JM, Miller-Graziano C, Barnard GF. Loss of chemokine SDF-1alpha-mediated CXCR4 signalling and receptor internalization in human hepatoma cell line HepG2. Cell Signal. 2001 May; 13(5):311-9. PMID: 11369512.
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Irwin RS, Madison JM. Symptom research on chronic cough: a historical perspective. Ann Intern Med. 2001 May 1; 134(9 Pt 2):809-14. PMID: 11346315.
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Irwin RS, Madison JM. The diagnosis and treatment of cough. N Engl J Med. 2000 Dec 7; 343(23):1715-21. PMID: 11106722.
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Ethier MF, Dextradeur T, Schaefer OP, Madison JM. Effects of salmeterol on muscarinic inhibition of adenylyl cyclase in bovine trachealis cells. Life Sci. 2000 Oct 20; 67(22):2753-8. PMID: 11105991.
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Irwin RS, Madison JM, Fraire AE. The cough reflex and its relation to gastroesophageal reflux. Am J Med. 2000 Mar 6; 108 Suppl 4a:73S-78S. PMID: 10718456.
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Irwin RS, Madison JM. Anatomical diagnostic protocol in evaluating chronic cough with specific reference to gastroesophageal reflux disease. Am J Med. 2000 Mar 6; 108 Suppl 4a:126S-130S. PMID: 10718465.
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Madison JM, Ethier MF, Yamaguchi H. Refilling of caffeine-sensitive intracellular calcium stores in bovine airway smooth muscle cells. Am J Physiol. 1998 Nov; 275(5 Pt 1):L852-60. PMID: 9815101.
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Madison JM, Irwin RS. Chronic obstructive pulmonary disease. Lancet. 1998 Aug 8; 352(9126):467-73. PMID: 9708769.
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Madison JM, Yamaguchi H. Muscarinic inhibition of adenylyl cyclase regulates intracellular calcium in single airway smooth muscle cells. Am J Physiol. 1996 Feb; 270(2 Pt 1):L208-14. PMID: 8779989.
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Ethier MF, Schaefer OP, Samant N, Yamaguchi H, Madison JM. Muscarinic receptor reserve for inhibition of cAMP accumulation in bovine trachealis cells. Am J Physiol. 1996 Feb; 270(2 Pt 1):L199-207. PMID: 8779988.
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Schaefer OP, Ethier MF, Madison JM. Muscarinic regulation of cyclic AMP in bovine trachealis cells. Am J Respir Cell Mol Biol. 1995 Aug; 13(2):217-26. PMID: 7626289.
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Yamaguchi H, Kajita J, Madison JM. Isoproterenol increases peripheral [Ca2+]i and decreases inner [Ca2+]i in single airway smooth muscle cells. Am J Physiol. 1995 Mar; 268(3 Pt 1):C771-9. PMID: 7900780.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1995 | 2 | 1996 | 2 | 1998 | 2 | 2000 | 4 | 2001 | 4 | 2002 | 3 | 2003 | 2 | 2005 | 4 | 2006 | 1 | 2008 | 3 | 2010 | 1 | 2012 | 1 | 2019 | 1 |
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