Interleukin-4

"Interleukin-4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.

Descriptor ID	D015847
MeSH Number(s)	D12.644.276.374.465.186 D12.776.467.374.465.178 D23.529.374.465.186
Concept/Terms	Interleukin-4 Interleukin-4 Interleukin 4 B-Cell Growth Factor-1 B Cell Growth Factor 1 B-Cell Growth Factor-I B Cell Growth Factor I B-Cell Proliferating Factor B Cell Proliferating Factor B-Cell Stimulating Factor-1 B Cell Stimulating Factor 1 B-Cell Stimulatory Factor 1 B-Cell Stimulatory Factor-1 BCGF-1 Binetrakin BSF-1 IL-4 IL4 Mast Cell Growth Factor-2 Mast Cell Growth Factor 2 MCGF-2 B Cell Stimulatory Factor-1 B Cell Stimulatory Factor 1

Below are MeSH descriptors whose meaning is more general than "Interleukin-4".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-4 [D12.644.276.374.465.186]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-4 [D12.776.467.374.465.178]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-4 [D23.529.374.465.186]

Below are MeSH descriptors whose meaning is related to "Interleukin-4".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-4" by people in this website by year, and whether "Interleukin-4" was a major or minor topic of these publications.

Bar chart showing 89 publications over 23 distinct years, with a maximum of 11 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	3	0	3
1996	1	1	2
1997	1	1	2
1998	1	7	8
1999	1	3	4
2000	3	1	4
2001	3	7	10
2002	3	8	11
2003	1	2	3
2004	1	3	4
2005	5	3	8
2006	0	3	3
2007	1	3	4
2008	1	3	4
2009	1	1	2
2011	0	1	1
2012	0	3	3
2013	0	1	1
2014	1	4	5
2015	0	4	4
2017	1	0	1
2021	0	1	1
2024	1	0	1

Below are the most recent publications written about "Interleukin-4" by people in Profiles.

Ranjitkar S, Krajewski D, Tedeschi C, Perez NM, Jordan N, Gregory K, Schneider SS, Mathias CB. Mast cell responses in a mouse model of food allergy are regulated via a ST2/IL-4 axis. Allergy. 2024 Sep; 79(9):2561-2564.

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de Freitas CL, Polonio CM, Brand?o WN, Rossato C, Zanluqui NG, de Oliveira LG, de Oliveira MG, Evangelista LP, Halpern S, Maluf M, Czresnia CE, Perin P, de Almeida DC, Peron JPS. Human Fallopian Tube - Derived Mesenchymal Stem Cells Inhibit Experimental Autoimmune Encephalomyelitis by Suppressing Th1/Th17 Activation and Migration to Central Nervous System. Stem Cell Rev Rep. 2022 02; 18(2):609-625.

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Xi R, Montague J, Lin X, Lu C, Lei W, Tanaka K, Zhang YV, Xu X, Zheng X, Zhou X, Urban JF, Iwatsuki K, Margolskee RF, Matsumoto I, Tizzano M, Li J, Jiang P. Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity. Proc Natl Acad Sci U S A. 2021 07 27; 118(30).

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Chen C, Smith AD, Cheung L, Pham Q, Urban JF, Dawson HD. Potentiation of IL-4 Signaling by Retinoic Acid in Intestinal Epithelial Cells and Macrophages-Mechanisms and Targets. Front Immunol. 2020; 11:605.

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Chen C, Perry TL, Chitko-McKown CG, Smith AD, Cheung L, Beshah E, Urban JF, Dawson HD. The regulatory actions of retinoic acid on M2 polarization of porcine macrophages. Dev Comp Immunol. 2019 09; 98:20-33.

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Li Y, Guan X, Liu W, Chen HL, Truscott J, Beyatli S, Metwali A, Weiner GJ, Zavazava N, Blumberg RS, Urban JF, Blazar BR, Elliott DE, Ince MN. Helminth-Induced Production of TGF-? and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells. J Immunol. 2018 11 15; 201(10):2910-2922.

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Lorentsen KJ, Cho JJ, Luo X, Zuniga AN, Urban JF, Zhou L, Gharaibeh R, Jobin C, Kladde MP, Avram D. Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma. Nat Commun. 2018 04 26; 9(1):1679.

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Sander J, Schmidt SV, Cirovic B, McGovern N, Papantonopoulou O, Hardt AL, Aschenbrenner AC, Kreer C, Quast T, Xu AM, Schmidleithner LM, Theis H, Thi Huong LD, Sumatoh HRB, Lauterbach MAR, Schulte-Schrepping J, G?nther P, Xue J, Ba?ler K, Ulas T, Klee K, Katzmarski N, Herresthal S, Krebs W, Martin B, Latz E, H?ndler K, Kraut M, Kolanus W, Beyer M, Falk CS, Wiegmann B, Burgdorf S, Melosh NA, Newell EW, Ginhoux F, Schlitzer A, Schultze JL. Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity. 2017 12 19; 47(6):1051-1066.e12.

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Shay AE, Diwakar BT, Guan BJ, Narayan V, Urban JF, Prabhu KS. IL-4 up-regulates cyclooxygenase-1 expression in macrophages. J Biol Chem. 2017 09 01; 292(35):14544-14555.

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Brodeur TY, Robidoux TE, Weinstein JS, Craft J, Swain SL, Marshak-Rothstein A. IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells. J Immunol. 2015 Dec 01; 195(11):5251-60.

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