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Li J, Lambright DG, Hsu VW. Coordination of Grp1 recruitment mechanisms by its phosphorylation. Mol Biol Cell. 2020 Oct 07; mbcE20030173. PMID: 33026967.
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Struck MW, Pazour GJ, Lambright DG. X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson's Disease. Structure. 2020 Apr 07; 28(4):385-387. PMID: 32268075.
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Das S, Malaby AW, Nawrotek A, Zhang W, Zeghouf M, Maslen S, Skehel M, Chakravarthy S, Irving TC, Bilsel O, Cherfils J, Lambright DG. Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes. Structure. 2019 Oct 05. PMID: 31601460.
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Sztul E, Chen PW, Casanova JE, Cherfils J, Dacks JB, Lambright DG, Lee FS, Randazzo PA, Santy LC, Schürmann A, Wilhelmi I, Yohe ME, Kahn RA. ARF GTPases and their GEFs and GAPs: concepts and challenges. Mol Biol Cell. 2019 05 15; 30(11):1249-1271. PMID: 31084567.
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Duan J, Lambright DG. TRAPPing a Rab GTPase by the Tail. Dev Cell. 2019 Jan 07; 48(1):9-11. PMID: 30620905.
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Malaby AW, Das S, Chakravarthy S, Irving TC, Bilsel O, Lambright DG. Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors. Structure. 2018 Jan 02; 26(1):106-117.e6. PMID: 29276036.
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Das S, Lambright DG. Membrane Trafficking: An Endosome Tether Meets a Rab and Collapses. Curr Biol. 2016 Oct 24; 26(20):R927-R929. PMID: 27780062.
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Kahn RA, Lambright D, De Matteis A. Special Issue: GTPases in trafficking, autophagy, and disease (FASEB SRC). Small GTPases. 2016 Oct; 7(4):187. PMID: 27880519.
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Mishra AK, Lambright DG. Invited review: Small GTPases and their GAPs. Biopolymers. 2016 Aug; 105(8):431-48. PMID: 26972107.
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Kahn RA, Lambright DG. A PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1. Structure. 2015 Nov 3; 23(11):1971-3. PMID: 26536378.
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Malaby AW, Chakravarthy S, Irving TC, Kathuria SV, Bilsel O, Lambright DG. Methods for analysis of size-exclusion chromatography-small-angle X-ray scattering and reconstruction of protein scattering. J Appl Crystallogr. 2015 Aug 1; 48(Pt 4):1102-1113. PMID: 26306089.
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Mishra AK, Lambright DG. High-throughput assay for profiling the substrate specificity of Rab GTPase-activating proteins. Methods Mol Biol. 2015; 1298:47-60. PMID: 25800831.
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Priya A, Kalaidzidis IV, Kalaidzidis Y, Lambright D, Datta S. Molecular insights into Rab7-mediated endosomal recruitment of core retromer: deciphering the role of Vps26 and Vps35. Traffic. 2015 Jan; 16(1):68-84. PMID: 25367362.
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Stockler S, Corvera S, Lambright D, Fogarty K, Nosova E, Leonard D, Steinfeld R, Ackerley C, Shyr C, Au N, Selby K, van Allen M, Vallance H, Wevers R, Watkins D, Rosenblatt D, Ross CJ, Conibear E, Wasserman W, van Karnebeek C. Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking. Orphanet J Rare Dis. 2014 Sep 20; 9:141. PMID: 25233840.
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Rahman M, Nirala NK, Singh A, Zhu LJ, Taguchi K, Bamba T, Fukusaki E, Shaw LM, Lambright DG, Acharya JK, Acharya UR. Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase ß and regulates complex V activity. J Cell Biol. 2014 Jul 21; 206(2):289-305. PMID: 25023514.
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Hubber A, Arasaki K, Nakatsu F, Hardiman C, Lambright D, De Camilli P, Nagai H, Roy CR. The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins. PLoS Pathog. 2014 Jul; 10(7):e1004222. PMID: 24992562.
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Del Campo CM, Mishra AK, Wang YH, Roy CR, Janmey PA, Lambright DG. Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM. Structure. 2014 Mar 4; 22(3):397-408. PMID: 24530282.
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Malaby AW, van den Berg B, Lambright DG. Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14213-8. PMID: 23940353.
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Mishra AK, Del Campo CM, Collins RE, Roy CR, Lambright DG. The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism. J Biol Chem. 2013 Aug 16; 288(33):24000-11. PMID: 23821544.
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Mannstadt M, Harris M, Bravenboer B, Chitturi S, Dreijerink KM, Lambright DG, Lim ET, Daly MJ, Gabriel S, Jüppner H. Germline mutations affecting Ga11 in hypoparathyroidism. N Engl J Med. 2013 Jun 27; 368(26):2532-4. PMID: 23802536.
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Tan SX, Ng Y, Burchfield JG, Ramm G, Lambright DG, Stöckli J, James DE. The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes. Mol Cell Biol. 2012 Dec; 32(24):4946-59. PMID: 23045393.
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Davey JR, Humphrey SJ, Junutula JR, Mishra AK, Lambright DG, James DE, Stöckli J. TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes. Traffic. 2012 Oct; 13(10):1429-41. PMID: 22762500.
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Nottingham RM, Pusapati GV, Ganley IG, Barr FA, Lambright DG, Pfeffer SR. RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. J Biol Chem. 2012 Jun 29; 287(27):22740-8. PMID: 22637480.
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Li J, Malaby AW, Famulok M, Sabe H, Lambright DG, Hsu VW. Grp1 plays a key role in linking insulin signaling to glut4 recycling. Dev Cell. 2012 Jun 12; 22(6):1286-98. PMID: 22609160.
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Navaroli DM, Bellvé KD, Standley C, Lifshitz LM, Cardia J, Lambright D, Leonard D, Fogarty KE, Corvera S. Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):E471-80. PMID: 22308388.
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Nottingham RM, Ganley IG, Barr FA, Lambright DG, Pfeffer SR. RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. J Biol Chem. 2011 Sep 23; 286(38):33213-22. PMID: 21808068.
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DiNitto JP, Lee MT, Malaby AW, Lambright DG. Specificity and membrane partitioning of Grsp1 signaling complexes with Grp1 family Arf exchange factors. Biochemistry. 2010 Jul 27; 49(29):6083-92. PMID: 20527794.
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Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP. A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem. 2010 Sep 3; 285(36):27581-9. PMID: 20587420.
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Mishra A, Eathiraj S, Corvera S, Lambright DG. Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10866-71. PMID: 20534488.
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Chotard L, Mishra AK, Sylvain MA, Tuck S, Lambright DG, Rocheleau CE. TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans. Mol Biol Cell. 2010 Jul 1; 21(13):2285-96. PMID: 20462958.
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Barr F, Lambright DG. Rab GEFs and GAPs. Curr Opin Cell Biol. 2010 Aug; 22(4):461-70. PMID: 20466531.
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Fang Z, Takizawa N, Wilson KA, Smith TC, Delprato A, Davidson MW, Lambright DG, Luna EJ. The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility. Traffic. 2010 Jun; 11(6):782-99. PMID: 20331534.
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Lee MT, Mishra A, Lambright DG. Structural mechanisms for regulation of membrane traffic by rab GTPases. Traffic. 2009 Oct; 10(10):1377-89. PMID: 19522756.
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Leonard D, Hayakawa A, Lawe D, Lambright D, Bellve KD, Standley C, Lifshitz LM, Fogarty KE, Corvera S. Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes. J Cell Sci. 2008 Oct 15; 121(Pt 20):3445-58. PMID: 18827013.
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DiNitto JP, Delprato A, Gabe Lee MT, Cronin TC, Huang S, Guilherme A, Czech MP, Lambright DG. Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell. 2007 Nov 30; 28(4):569-83. PMID: 18042453.
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Ingmundson A, Delprato A, Lambright DG, Roy CR. Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature. 2007 Nov 15; 450(7168):365-9. PMID: 17952054.
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Sklan EH, Serrano RL, Einav S, Pfeffer SR, Lambright DG, Glenn JS. TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication. J Biol Chem. 2007 Dec 14; 282(50):36354-61. PMID: 17901050.
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Mukhopadhyay A, Pan X, Lambright DG, Tissenbaum HA. An endocytic pathway as a target of tubby for regulation of fat storage. EMBO Rep. 2007 Oct; 8(10):931-8. PMID: 17762880.
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Mishra AK, Gangwani L, Davis RJ, Lambright DG. Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13930-5. PMID: 17704259.
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Delprato A, Lambright DG. Structural basis for Rab GTPase activation by VPS9 domain exchange factors. Nat Struct Mol Biol. 2007 May; 14(5):406-12. PMID: 17450153.
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Hayakawa A, Hayes S, Leonard D, Lambright D, Corvera S. Evolutionarily conserved structural and functional roles of the FYVE domain. Biochem Soc Symp. 2007; (74):95-105. PMID: 17233583.
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Eathiraj S, Mishra A, Prekeris R, Lambright DG. Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes. J Mol Biol. 2006 Nov 24; 364(2):121-35. PMID: 17007872.
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Morrison AR, Moss J, Stevens LA, Evans JE, Farrell C, Merithew E, Lambright DG, Greiner DL, Mordes JP, Rossini AA, Bortell R. ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose). J Biol Chem. 2006 Nov 3; 281(44):33363-72. PMID: 16931513.
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Murata T, Delprato A, Ingmundson A, Toomre DK, Lambright DG, Roy CR. The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor. Nat Cell Biol. 2006 Sep; 8(9):971-7. PMID: 16906144.
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Hayakawa A, Leonard D, Murphy S, Hayes S, Soto M, Fogarty K, Standley C, Bellve K, Lambright D, Mello C, Corvera S. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Proc Natl Acad Sci U S A. 2006 Aug 8; 103(32):11928-33. PMID: 16873553.
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Pan X, Eathiraj S, Munson M, Lambright DG. TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Nature. 2006 Jul 20; 442(7100):303-6. PMID: 16855591.
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DiNitto JP, Lambright DG. Membrane and juxtamembrane targeting by PH and PTB domains. Biochim Biophys Acta. 2006 Aug; 1761(8):850-67. PMID: 16807090.
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Eathiraj S, Lambright DG. ESCRT complexes assembled and GLUEd. Structure. 2006 Apr; 14(4):631-2. PMID: 16615903.
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Eathiraj S, Pan X, Ritacco C, Lambright DG. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature. 2005 Jul 21; 436(7049):415-9. PMID: 16034420.
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Cronin TC, DiNitto JP, Czech MP, Lambright DG. Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J. 2004 Oct 1; 23(19):3711-20. PMID: 15359279.
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Delprato A, Merithew E, Lambright DG. Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5. Cell. 2004 Sep 3; 118(5):607-17. PMID: 15339665.
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DiNitto JP, Cronin TC, Lambright DG. Membrane recognition and targeting by lipid-binding domains. Sci STKE. 2003 Dec 16; 2003(213):re16. PMID: 14679290.
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Hayakawa A, Hayes SJ, Lawe DC, Sudharshan E, Tuft R, Fogarty K, Lambright D, Corvera S. Structural basis for endosomal targeting by FYVE domains. J Biol Chem. 2004 Feb 13; 279(7):5958-66. PMID: 14594806.
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Lawe DC, Sitouah N, Hayes S, Chawla A, Virbasius JV, Tuft R, Fogarty K, Lifshitz L, Lambright D, Corvera S. Essential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization. Mol Biol Cell. 2003 Jul; 14(7):2935-45. PMID: 12857876.
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Merithew E, Stone C, Eathiraj S, Lambright DG. Determinants of Rab5 interaction with the N terminus of early endosome antigen 1. J Biol Chem. 2003 Mar 7; 278(10):8494-500. PMID: 12493736.
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Weston CR, Lambright DG, Davis RJ. Signal transduction. MAP kinase signaling specificity. Science. 2002 Jun 28; 296(5577):2345-7. PMID: 12089430.
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Merithew E, Lambright DG. Calculating the potential of C2 domains for membrane binding. Dev Cell. 2002 Feb; 2(2):132-3. PMID: 11832238.
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Zhu Z, Delprato A, Merithew E, Lambright DG. Determinants of the broad recognition of exocytic Rab GTPases by Mss4. Biochemistry. 2001 Dec 25; 40(51):15699-706. PMID: 11747446.
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Dumas JJ, Merithew E, Sudharshan E, Rajamani D, Hayes S, Lawe D, Corvera S, Lambright DG. Multivalent endosome targeting by homodimeric EEA1. Mol Cell. 2001 Nov; 8(5):947-58. PMID: 11741531.
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Lawe DC, Chawla A, Merithew E, Dumas J, Carrington W, Fogarty K, Lifshitz L, Tuft R, Lambright D, Corvera S. Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1. J Biol Chem. 2002 Mar 8; 277(10):8611-7. PMID: 11602609.
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Zhu Z, Dumas JJ, Lietzke SE, Lambright DG. A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release. Biochemistry. 2001 Mar 13; 40(10):3027-36. PMID: 11258916.
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Merithew E, Hatherly S, Dumas JJ, Lawe DC, Heller-Harrison R, Lambright DG. Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition. J Biol Chem. 2001 Apr 27; 276(17):13982-8. PMID: 11278565.
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Lietzke SE, Bose S, Cronin T, Klarlund J, Chawla A, Czech MP, Lambright DG. Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. Mol Cell. 2000 Aug; 6(2):385-94. PMID: 10983985.
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Lawe DC, Patki V, Heller-Harrison R, Lambright D, Corvera S. The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization. J Biol Chem. 2000 Feb 4; 275(5):3699-705. PMID: 10652369.
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Dumas JJ, Zhu Z, Connolly JL, Lambright DG. Structural basis of activation and GTP hydrolysis in Rab proteins. Structure. 1999 Apr 15; 7(4):413-23. PMID: 10196122.
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Dumas JJ, Lambright DG. Gs alpha meets its target--shedding light on a key signal transduction event. Structure. 1998 Apr 15; 6(4):407-11. PMID: 9562564.
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Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB. The 2.0 A crystal structure of a heterotrimeric G protein. Nature. 1996 Jan 25; 379(6563):311-9. PMID: 8552184.
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Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature. 1996 Jan 25; 379(6563):369-74. PMID: 8552196.
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Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB. GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Nature. 1994 Nov 17; 372(6503):276-9. PMID: 7969474.
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Balasubramanian S, Lambright DG, Simmons JH, Gill SJ, Boxer SG. Determination of the carbon monoxide binding constants of myoglobin mutants: comparison of kinetic and equilibrium methods. Biochemistry. 1994 Jul 12; 33(27):8355-60. PMID: 8031769.
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Lambright DG, Noel JP, Hamm HE, Sigler PB. Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature. 1994 Jun 23; 369(6482):621-8. PMID: 8208289.
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Lambright DG, Balasubramanian S, Decatur SM, Boxer SG. Anatomy and dynamics of a ligand-binding pathway in myoglobin: the roles of residues 45, 60, 64, and 68. Biochemistry. 1994 May 10; 33(18):5518-25. PMID: 8180174.
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Petrich JW, Lambry JC, Balasubramanian S, Lambright DG, Boxer SG, Martin JL. Ultrafast measurements of geminate recombination of NO with site-specific mutants of human myoglobin. J Mol Biol. 1994 May 6; 238(3):437-44. PMID: 8176734.
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Lambright DG, Balasubramanian S, Boxer SG. Dynamics of protein relaxation in site-specific mutants of human myoglobin. Biochemistry. 1993 Sep 28; 32(38):10116-24. PMID: 8399137.
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Balasubramanian S, Lambright DG, Boxer SG. Perturbations of the distal heme pocket in human myoglobin mutants probed by infrared spectroscopy of bound CO: correlation with ligand binding kinetics. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4718-22. PMID: 8506324.
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Balasubramanian S, Lambright DG, Marden MC, Boxer SG. CO recombination to human myoglobin mutants in glycerol-water solutions. Biochemistry. 1993 Mar 9; 32(9):2202-12. PMID: 8443162.
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Hubbard SR, Hendrickson WA, Lambright DG, Boxer SG. X-ray crystal structure of a recombinant human myoglobin mutant at 2.8 A resolution. J Mol Biol. 1990 May 20; 213(2):215-8. PMID: 2342104.
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Lambright DG, Balasubramanian S, Boxer SG. Ligand and proton exchange dynamics in recombinant human myoglobin mutants. J Mol Biol. 1989 May 5; 207(1):289-99. PMID: 2544737.
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Varadarajan R, Lambright DG, Boxer SG. Electrostatic interactions in wild-type and mutant recombinant human myoglobins. Biochemistry. 1989 May 2; 28(9):3771-81. PMID: 2751994.
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Johnson DR, Lambright DG, Wong SS. Lactose synthase: effect of alpha-lactalbumin on substrate activity of N-acylglucosamines. Biochim Biophys Acta. 1985 Dec 20; 832(3):373-7. PMID: 3935175.
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Lambright DG, Lee TK, Wong SS. Association-dissociation modulation of enzyme activity: case of lactose synthase. Biochemistry. 1985 Feb 12; 24(4):910-4. PMID: 3922406.