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Neal Silverman PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB-313
Worcester MA 01605
Phone508-856-5826
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases And Immunology

    InstitutionUMMS - School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology


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    Collapse Biography 
    Collapse education and training
    University of California, Berkeley, Berkeley, CA, United StatesBAMolecular Biology
    Massachusetts Institute of Technology, Cambridge, MA, United StatesPHDBiology
    Collapse awards and honors
    1996 - 1999Helen Hay Whitney Fellow, MCB, Harvard University
    2005 - 2007Ellison Foundation Young Investigator in Global Pathogenesis
    2006GSBS Faculty Achievement Award for Outstanding Contributions in the Classroom Settings
    2006Presidential Early Career Award for Scientists and Engineers (PECASE).
    2007 - 2012GSBS Faculty Achievement Award for outstanding contributions to curriculum development
    2010Dean's Award for Outstanding Faculty Contribution to Graduate Education
    2012Burroughs Welcome Fund, Investigator in Pathogenesis of Infectious Disease
    2015Dean's Award for outstanding faculty contribution to graduate education
    2017Kenneth Rainin Foundation Innovator Award
    2017Dean's Award for Outstanding Faculty Contribution to Graduate Education, UMMS

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. West C, Rus F, Chen Y, Kleino A, Gangloff M, Gammon DB, Silverman N. IIV-6 Inhibits NF-?B Responses in Drosophila. Viruses. 2019 May 01; 11(5). PMID: 31052481.
      View in: PubMed
    2. Kleino A, Silverman N. Regulation of the Drosophila Imd pathway by signaling amyloids. Insect Biochem Mol Biol. 2019 Mar 08. PMID: 30857831.
      View in: PubMed
    3. Nandy A, Lin L, Velentzas PD, Wu LP, Baehrecke EH, Silverman N. The NF-?B Factor Relish Regulates Atg1 Expression and Controls Autophagy. Cell Rep. 2018 Nov 20; 25(8):2110-2120.e3. PMID: 30463009.
      View in: PubMed
    4. Goto A, Okado K, Martins N, Cai H, Barbier V, Lamiable O, Troxler L, Santiago E, Kuhn L, Paik D, Silverman N, Holleufer A, Hartmann R, Liu J, Peng T, Hoffmann JA, Meignin C, Daeffler L, Imler JL. The Kinase IKKß Regulates a STING- and NF-?B-Dependent Antiviral Response Pathway in Drosophila. Immunity. 2018 Aug 09. PMID: 30119996.
      View in: PubMed
    5. Zheng W, Rus F, Hernandez A, Kang P, Goldman W, Silverman N, Tatar M. Dehydration triggers ecdysone-mediated recognition-protein priming and elevated anti-bacterial immune responses in Drosophila Malpighian tubule renal cells. BMC Biol. 2018 May 31; 16(1):60. PMID: 29855367.
      View in: PubMed
    6. West C, Silverman N. p38b and JAK-STAT signaling protect against Invertebrate iridescent virus 6 infection in Drosophila. PLoS Pathog. 2018 05; 14(5):e1007020. PMID: 29746571.
      View in: PubMed
    7. Okuda K, Silverman N. Drosophila Model of Leishmania amazonensis Infection. Bio Protoc. 2017 Dec 05; 7(23). PMID: 29276726.
      View in: PubMed
    8. Kleino A, Ramia NF, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H, Li J, Silverman N. Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-?B Signaling. Immunity. 2017 10 17; 47(4):635-647.e6. PMID: 29045898.
      View in: PubMed
    9. Monahan AJ, Silverman N. Relish the Thought and Channel Your Chloride, for Bacterial Clearance Depends on It. Cell Host Microbe. 2017 Jun 14; 21(6):657-659. PMID: 28618263.
      View in: PubMed
    10. Paik D, Monahan A, Caffrey DR, Elling R, Goldman WE, Silverman N. SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans. J Immunol. 2017 Jul 01; 199(1):263-270. PMID: 28539433.
      View in: PubMed
    11. West C, Silverman N. Drosophilosophical: Re-thinking Adaptive Immunity in the Fly. Cell. 2017 Apr 06; 169(2):188-190. PMID: 28388404.
      View in: PubMed
    12. Chen L, Paquette N, Mamoor S, Rus F, Nandy A, Leszyk J, Shaffer SA, Silverman N. Innate immune signaling in Drosophila is regulated by TGFß-activated kinase (Tak1)-triggered ubiquitin editing. J Biol Chem. 2017 Apr 04. PMID: 28377500.
      View in: PubMed
    13. Gammon DB, Ishidate T, Li L, Gu W, Silverman N, Mello CC. The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans. Curr Biol. 2017 Feb 23. PMID: 28262484.
      View in: PubMed
    14. Monahan A, Kleino A, Silverman N. ReaDAPting the Role of PGRP-SD in Bacterial Sensing and Immune Activation. Immunity. 2016 Nov 15; 45(5):951-953. PMID: 27851920.
      View in: PubMed
    15. Okuda K, Tong M, Dempsey B, Moore KJ, Gazzinelli RT, Silverman N. Leishmania amazonensis Engages CD36 to Drive Parasitophorous Vacuole Maturation. PLoS Pathog. 2016 Jun; 12(6):e1005669. PMID: 27280707.
      View in: PubMed
    16. Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D. Control of the innate immune response by the mevalonate pathway. Nat Immunol. 2016 Aug; 17(8):922-9. PMID: 27270400.
      View in: PubMed
    17. Gulia-Nuss M, Nuss AB, Meyer JM, Sonenshine DE, Roe RM, Waterhouse RM, Sattelle DB, de la Fuente J, Ribeiro JM, Megy K, Thimmapuram J, Miller JR, Walenz BP, Koren S, Hostetler JB, Thiagarajan M, Joardar VS, Hannick LI, Bidwell S, Hammond MP, Young S, Zeng Q, Abrudan JL, Almeida FC, Ayllón N, Bhide K, Bissinger BW, Bonzon-Kulichenko E, Buckingham SD, Caffrey DR, Caimano MJ, Croset V, Driscoll T, Gilbert D, Gillespie JJ, Giraldo-Calderón GI, Grabowski JM, Jiang D, Khalil SM, Kim D, Kocan KM, Koci J, Kuhn RJ, Kurtti TJ, Lees K, Lang EG, Kennedy RC, Kwon H, Perera R, Qi Y, Radolf JD, Sakamoto JM, Sánchez-Gracia A, Severo MS, Silverman N, Šimo L, Tojo M, Tornador C, Van Zee JP, Vázquez J, Vieira FG, Villar M, Wespiser AR, Yang Y, Zhu J, Arensburger P, Pietrantonio PV, Barker SC, Shao R, Zdobnov EM, Hauser F, Grimmelikhuijzen CJ, Park Y, Rozas J, Benton R, Pedra JH, Nelson DR, Unger MF, Tubio JM, Tu Z, Robertson HM, Shumway M, Sutton G, Wortman JR, Lawson D, Wikel SK, Nene VM, Fraser CM, Collins FH, Birren B, Nelson KE, Caler E, Hill CA. Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nat Commun. 2016 Feb 09; 7:10507. PMID: 26856261.
      View in: PubMed
    18. Liu B, Zheng Y, Yin F, Yu J, Silverman N, Pan D. Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila. Cell. 2016 Jan 28; 164(3):406-19. PMID: 26824654.
      View in: PubMed
    19. Buchon N, Silverman N, Cherry S. Immunity in Drosophila melanogaster--from microbial recognition to whole-organism physiology. Nat Rev Immunol. 2014 Dec; 14(12):796-810. PMID: 25421701.
      View in: PubMed
    20. Dissel S, Seugnet L, Thimgan MS, Silverman N, Angadi V, Thacher PV, Burnham MM, Shaw PJ. Differential activation of immune factors in neurons and glia contribute to individual differences in resilience/vulnerability to sleep disruption. Brain Behav Immun. 2015 Jul; 47:75-85. PMID: 25451614; PMCID: PMC4416079.
    21. Donlea JM, Ramanan N, Silverman N, Shaw PJ. Genetic rescue of functional senescence in synaptic and behavioral plasticity. Sleep. 2014 Sep 01; 37(9):1427-37. PMID: 25142573.
      View in: PubMed
    22. Ganesan S, Rathinam VA, Bossaller L, Army K, Kaiser WJ, Mocarski ES, Dillon CP, Green DR, Mayadas TN, Levitz SM, Hise AG, Silverman N, Fitzgerald KA. Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1ß production in response to ß-glucans and the fungal pathogen, Candida albicans. J Immunol. 2014 Sep 01; 193(5):2519-30. PMID: 25063877.
      View in: PubMed
    23. Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JH, Conte D, Gundersen-Rindal DE, Marshall WL, Yates JR, Silverman N, Mello CC. A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection. Elife. 2014 Jun 25; 3. PMID: 24966209.
      View in: PubMed
    24. Kim CH, Paik D, Rus F, Silverman N. The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35. J Biol Chem. 2014 Jul 18; 289(29):20092-101. PMID: 24891502.
      View in: PubMed
    25. Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7391-6. PMID: 24799678.
      View in: PubMed
    26. Gupta R, Ghosh S, Monks B, DeOliveira RB, Tzeng TC, Kalantari P, Nandy A, Bhattacharjee B, Chan J, Ferreira F, Rathinam V, Sharma S, Lien E, Silverman N, Fitzgerald K, Firon A, Trieu-Cuot P, Henneke P, Golenbock DT. RNA and ß-hemolysin of group B Streptococcus induce interleukin-1ß (IL-1ß) by activating NLRP3 inflammasomes in mouse macrophages. J Biol Chem. 2014 May 16; 289(20):13701-5. PMID: 24692555.
      View in: PubMed
    27. Marinotti O, Cerqueira GC, de Almeida LG, Ferro MI, Loreto EL, Zaha A, Teixeira SM, Wespiser AR, Almeida E Silva A, Schlindwein AD, Pacheco AC, Silva AL, Graveley BR, Walenz BP, Lima Bde A, Ribeiro CA, Nunes-Silva CG, de Carvalho CR, Soares CM, de Menezes CB, Matiolli C, Caffrey D, Araújo DA, de Oliveira DM, Golenbock D, Grisard EC, Fantinatti-Garboggini F, de Carvalho FM, Barcellos FG, Prosdocimi F, May G, Azevedo Junior GM, Guimarães GM, Goldman GH, Padilha IQ, Batista Jda S, Ferro JA, Ribeiro JM, Fietto JL, Dabbas KM, Cerdeira L, Agnez-Lima LF, Brocchi M, de Carvalho MO, Teixeira Mde M, Diniz Maia Mde M, Goldman MH, Cruz Schneider MP, Felipe MS, Hungria M, Nicolás MF, Pereira M, Montes MA, Cantão ME, Vincentz M, Rafael MS, Silverman N, Stoco PH, Souza RC, Vicentini R, Gazzinelli RT, Neves Rde O, Silva R, Astolfi-Filho S, Maciel TE, Urményi TP, Tadei WP, Camargo EP, de Vasconcelos AT. The genome of Anopheles darlingi, the main neotropical malaria vector. Nucleic Acids Res. 2013 Aug; 41(15):7387-400. PMID: 23761445.
      View in: PubMed
    28. Kleino A, Silverman N. The Drosophila IMD pathway in the activation of the humoral immune response. Dev Comp Immunol. 2014 Jan; 42(1):25-35. PMID: 23721820.
      View in: PubMed
    29. Rus F, Flatt T, Tong M, Aggarwal K, Okuda K, Kleino A, Yates E, Tatar M, Silverman N. Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity. EMBO J. 2013 May 29; 32(11):1626-38. PMID: 23652443.
      View in: PubMed
    30. Warmbold C, Uliczka K, Rus F, Suck R, Petersen A, Silverman N, Ulmer AJ, Heine H, Roeder T. Dermatophagoides pteronyssinus major allergen 1 activates the innate immune response of the fruit fly Drosophila melanogaster. J Immunol. 2013 Jan 01; 190(1):366-71. PMID: 23203927.
      View in: PubMed
    31. Bossaller L, Chiang PI, Schmidt-Lauber C, Ganesan S, Kaiser WJ, Rathinam VA, Mocarski ES, Subramanian D, Green DR, Silverman N, Fitzgerald KA, Marshak-Rothstein A, Latz E. Cutting edge: FAS (CD95) mediates noncanonical IL-1ß and IL-18 maturation via caspase-8 in an RIP3-independent manner. J Immunol. 2012 Dec 15; 189(12):5508-12. PMID: 23144495.
      View in: PubMed
    32. Paquette N, Conlon J, Sweet C, Rus F, Wilson L, Pereira A, Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis S, Fitzgerald KA, Stuart L, Silverman N. Serine/threonine acetylation of TGFß-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12710-5. PMID: 22802624.
      View in: PubMed
    33. Meinander A, Runchel C, Tenev T, Chen L, Kim CH, Ribeiro PS, Broemer M, Leulier F, Zvelebil M, Silverman N, Meier P. Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling. EMBO J. 2012 Jun 13; 31(12):2770-83. PMID: 22549468.
      View in: PubMed
    34. Kleino A, Silverman N. UnZIPping mechanisms of effector-triggered immunity in animals. Cell Host Microbe. 2012 Apr 19; 11(4):320-2. PMID: 22520459.
      View in: PubMed
    35. Rus F, Morlock K, Silverman N, Pham N, Kotwal GJ, Marshall WL. Characterization of poxvirus-encoded proteins that regulate innate immune signaling pathways. Methods Mol Biol. 2012; 890:273-88. PMID: 22688773.
      View in: PubMed
    36. Boyer L, Paquette N, Silverman N, Stuart LM. Bacterial effectors: learning on the fly. Adv Exp Med Biol. 2012; 710:29-36. PMID: 22127883.
      View in: PubMed
    37. Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, Erturk-Hasdemir D, Reichhart JM, Silverman N, Lacy-Hulbert A, Stuart LM. Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway. Immunity. 2011 Oct 28; 35(4):536-49. PMID: 22018470.
      View in: PubMed
    38. Ganesan S, Aggarwal K, Paquette N, Silverman N. NF-?B/Rel proteins and the humoral immune responses of Drosophila melanogaster. Curr Top Microbiol Immunol. 2011; 349:25-60. PMID: 20852987.
      View in: PubMed
    39. Charrière GM, Ip WE, Dejardin S, Boyer L, Sokolovska A, Cappillino MP, Cherayil BJ, Podolsky DK, Kobayashi KS, Silverman N, Lacy-Hulbert A, Stuart LM. Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters. J Biol Chem. 2010 Jun 25; 285(26):20147-54. PMID: 20406817.
      View in: PubMed
    40. Paquette N, Broemer M, Aggarwal K, Chen L, Husson M, Ertürk-Hasdemir D, Reichhart JM, Meier P, Silverman N. Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling. Mol Cell. 2010 Jan 29; 37(2):172-82. PMID: 20122400.
      View in: PubMed
    41. Okugawa T, Kaneko T, Yoshimura A, Silverman N, Hara Y. NOD1 and NOD2 mediate sensing of periodontal pathogens. J Dent Res. 2010 Feb; 89(2):186-91. PMID: 20040739.
      View in: PubMed
    42. Troll JV, Bent EH, Pacquette N, Wier AM, Goldman WE, Silverman N, McFall-Ngai MJ. Taming the symbiont for coexistence: a host PGRP neutralizes a bacterial symbiont toxin. Environ Microbiol. 2010 Aug; 12(8):2190-203. PMID: 21966913.
      View in: PubMed
    43. Helenius IT, Krupinski T, Turnbull DW, Gruenbaum Y, Silverman N, Johnson EA, Sporn PH, Sznajder JI, Beitel GJ. Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18710-5. PMID: 19846771.
      View in: PubMed
    44. Ertürk-Hasdemir D, Broemer M, Leulier F, Lane WS, Paquette N, Hwang D, Kim CH, Stöven S, Meier P, Silverman N. Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9779-84. PMID: 19497884.
      View in: PubMed
    45. Silverman N, Paquette N, Aggarwal K. Specificity and signaling in the Drosophila immune response. Invertebrate Surviv J. 2009 Jun 1; 6(2):163-174. PMID: 21625362.
      View in: PubMed
    46. Troll JV, Adin DM, Wier AM, Paquette N, Silverman N, Goldman WE, Stadermann FJ, Stabb EV, McFall-Ngai MJ. Peptidoglycan induces loss of a nuclear peptidoglycan recognition protein during host tissue development in a beneficial animal-bacterial symbiosis. Cell Microbiol. 2009 Jul; 11(7):1114-27. PMID: 19416268; PMCID: PMC2758052.
    47. Aggarwal K, Rus F, Vriesema-Magnuson C, Ertürk-Hasdemir D, Paquette N, Silverman N. Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway. PLoS Pathog. 2008 Aug 08; 4(8):e1000120. PMID: 18688280.
      View in: PubMed
    48. Flatt T, Heyland A, Rus F, Porpiglia E, Sherlock C, Yamamoto R, Garbuzov A, Palli SR, Tatar M, Silverman N. Hormonal regulation of the humoral innate immune response in Drosophila melanogaster. J Exp Biol. 2008 Aug; 211(Pt 16):2712-24. PMID: 18689425; PMCID: PMC2522372.
    49. Yano T, Mita S, Ohmori H, Oshima Y, Fujimoto Y, Ueda R, Takada H, Goldman WE, Fukase K, Silverman N, Yoshimori T, Kurata S. Autophagic control of listeria through intracellular innate immune recognition in drosophila. Nat Immunol. 2008 Aug; 9(8):908-16. PMID: 18604211; PMCID: PMC2562576.
    50. Aggarwal K, Silverman N. Positive and negative regulation of the Drosophila immune response. BMB Rep. 2008 Apr 30; 41(4):267-77. PMID: 18452646.
      View in: PubMed
    51. Silverman N, Paquette N. Immunology. The right resident bugs. Science. 2008 Feb 8; 319(5864):734-5. PMID: 18218861.
      View in: PubMed
    52. Aggrawal K, Silverman N. Peptidoglycan recognition in Drosophila. Biochem Soc Trans. 2007 Dec; 35(Pt 6):1496-500. PMID: 18031252.
      View in: PubMed
    53. Sweet CR, Conlon J, Golenbock DT, Goguen J, Silverman N. YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction. Cell Microbiol. 2007 Nov; 9(11):2700-15. PMID: 17608743.
      View in: PubMed
    54. Wu L, Silverman N. Fighting infection fly-style. Fly (Austin). 2007 Mar-Apr; 1(2):106-9. PMID: 19378452.
      View in: PubMed
    55. Cherry S, Silverman N. Host-pathogen interactions in drosophila: new tricks from an old friend. Nat Immunol. 2006 Sep; 7(9):911-7. PMID: 16924255.
      View in: PubMed
    56. Mitchell JA, Fitzgerald KA, Coyle A, Silverman N, Cartwright N. TOLLing away in Brazil. Nat Immunol. 2006 Jul; 7(7):675-9. PMID: 16785880.
      View in: PubMed
    57. Kaneko T, Yano T, Aggarwal K, Lim JH, Ueda K, Oshima Y, Peach C, Erturk-Hasdemir D, Goldman WE, Oh BH, Kurata S, Silverman N. PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Nat Immunol. 2006 Jul; 7(7):715-23. PMID: 16767093.
      View in: PubMed
    58. Lim JH, Kim MS, Kim HE, Yano T, Oshima Y, Aggarwal K, Goldman WE, Silverman N, Kurata S, Oh BH. Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins. J Biol Chem. 2006 Mar 24; 281(12):8286-95. PMID: 16428381.
      View in: PubMed
    59. Swaminathan CP, Brown PH, Roychowdhury A, Wang Q, Guan R, Silverman N, Goldman WE, Boons GJ, Mariuzza RA. Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs). Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):684-9. PMID: 16407132; PMCID: PMC1334652.
    60. Ertürk-Hasdemir D, Silverman N. Eater: a big bite into phagocytosis. Cell. 2005 Oct 21; 123(2):190-2. PMID: 16239137.
      View in: PubMed
    61. Zhou R, Silverman N, Hong M, Liao DS, Chung Y, Chen ZJ, Maniatis T. The role of ubiquitination in Drosophila innate immunity. J Biol Chem. 2005 Oct 07; 280(40):34048-55. PMID: 16081424.
      View in: PubMed
    62. Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX. Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli. Cell Signal. 2006 Apr; 18(4):441-8. PMID: 16014325.
      View in: PubMed
    63. Zerofsky M, Harel E, Silverman N, Tatar M. Aging of the innate immune response in Drosophila melanogaster. Aging Cell. 2005 Apr; 4(2):103-8. PMID: 15771614.
      View in: PubMed
    64. Kaneko T, Silverman N. Bacterial recognition and signalling by the Drosophila IMD pathway. Cell Microbiol. 2005 Apr; 7(4):461-9. PMID: 15760446.
      View in: PubMed
    65. Kaneko T, Golenbock D, Silverman N. Peptidoglycan recognition by the Drosophila Imd pathway. J Endotoxin Res. 2005; 11(6):383-9. PMID: 16303095.
      View in: PubMed
    66. Silverman N, Fitzgerald K. DUBbing down innate immunity. Nat Immunol. 2004 Oct; 5(10):1010-2. PMID: 15454928.
      View in: PubMed
    67. Kaneko T, Goldman WE, Mellroth P, Steiner H, Fukase K, Kusumoto S, Harley W, Fox A, Golenbock D, Silverman N. Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway. Immunity. 2004 May; 20(5):637-49. PMID: 15142531.
      View in: PubMed
    68. Silverman N, Zhou R, Erlich RL, Hunter M, Bernstein E, Schneider D, Maniatis T. Immune activation of NF-kappaB and JNK requires Drosophila TAK1. J Biol Chem. 2003 Dec 5; 278(49):48928-34. PMID: 14519762.
      View in: PubMed
    69. Stoven S, Silverman N, Junell A, Hedengren-Olcott M, Erturk D, Engstrom Y, Maniatis T, Hultmark D. Caspase-mediated processing of the Drosophila NF-kappaB factor Relish. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5991-6. PMID: 12732719; PMCID: PMC156314.
    70. Silverman N. Flies kNOw how to signal. Dev Cell. 2003 Jan; 4(1):5-6. PMID: 12530956.
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    71. Avila A, Silverman N, Diaz-Meco MT, Moscat J. The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway. Mol Cell Biol. 2002 Dec; 22(24):8787-95. PMID: 12446795; PMCID: PMC139865.
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