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Masaki Shirayama PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentRNA Therapeutics Institute
AddressUMass Chan Medical School
373 Plantation Street
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    Collapse Biography 
    Collapse education and training
    University of Tokyo, Tokyo, , JapanPHDBiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ding YH, Ochoa HJ, Ishidate T, Shirayama M, Mello CC. The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing. Cell Rep. 2023 05 30; 42(5):112408. PMID: 37083324.
      Citations: 2     Fields:    Translation:AnimalsCells
    2. Makeyeva YV, Shirayama M, Mello CC. Cues from mRNA splicing prevent default Argonaute silencing in C.?elegans. Dev Cell. 2021 09 27; 56(18):2636-2648.e4. PMID: 34547227.
      Citations: 4     Fields:    Translation:AnimalsCells
    3. Ishidate T, Ozturk AR, Durning DJ, Sharma R, Shen EZ, Chen H, Seth M, Shirayama M, Mello CC. ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals. Mol Cell. 2018 05 17; 70(4):639-649.e6. PMID: 29775580.
      Citations: 41     Fields:    Translation:AnimalsCells
    4. Shen EZ, Chen H, Ozturk AR, Tu S, Shirayama M, Tang W, Ding YH, Dai SY, Weng Z, Mello CC. Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C.?elegans Germline. Cell. 2018 02 22; 172(5):937-951.e18. PMID: 29456082.
      Citations: 96     Fields:    Translation:AnimalsCells
    5. Tang W, Seth M, Tu S, Shen EZ, Li Q, Shirayama M, Weng Z, Mello CC. A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C.?elegans. Dev Cell. 2018 03 26; 44(6):762-770.e3. PMID: 29456136.
      Citations: 23     Fields:    Translation:AnimalsCells
    6. Seth M, Shirayama M, Tang W, Shen EZ, Tu S, Lee HC, Weng Z, Mello CC. The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C.?elegans. Cell Rep. 2018 02 27; 22(9):2254-2264. PMID: 29456100.
      Citations: 26     Fields:    Translation:AnimalsCells
    7. Gnazzo MM, Uhlemann EE, Villarreal AR, Shirayama M, Dominguez EG, Skop AR. The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4. Mol Biol Cell. 2016 10 15; 27(20):3052-3064. PMID: 27559134.
      Citations: 12     Fields:    Translation:AnimalsCells
    8. Elewa A, Shirayama M, Kaymak E, Harrison PF, Powell DR, Du Z, Chute CD, Woolf H, Yi D, Ishidate T, Srinivasan J, Bao Z, Beilharz TH, Ryder SP, Mello CC. POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA. Dev Cell. 2015 Jul 06; 34(1):108-18. PMID: 26096734.
      Citations: 10     Fields:    Translation:AnimalsCells
    9. Kim H, Ishidate T, Ghanta KS, Seth M, Conte D, Shirayama M, Mello CC. A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans. Genetics. 2014 Aug; 197(4):1069-80. PMID: 24879462.
      Citations: 166     Fields:    Translation:AnimalsCells
    10. Shirayama M, Stanney W, Gu W, Seth M, Mello CC. The Vasa Homolog RDE-12 engages target mRNA and multiple argonaute proteins to promote RNAi in C. elegans. Curr Biol. 2014 Apr 14; 24(8):845-51. PMID: 24684931.
      Citations: 16     Fields:    Translation:AnimalsCells
    11. Ishidate T, Elewa A, Kim S, Mello CC, Shirayama M. Divide and differentiate: CDK/Cyclins and the art of development. Cell Cycle. 2014; 13(9):1384-91. PMID: 24675894.
      Citations: 20     Fields:    Translation:HumansAnimals
    12. Seth M, Shirayama M, Gu W, Ishidate T, Conte D, Mello CC. The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression. Dev Cell. 2013 Dec 23; 27(6):656-63. PMID: 24360782.
      Citations: 116     Fields:    Translation:AnimalsCells
    13. Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D, Yates JR, Mello CC. Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans. Cell. 2013 Dec 19; 155(7):1532-44. PMID: 24360276.
      Citations: 90     Fields:    Translation:AnimalsCells
    14. Ishidate T, Kim S, Mello C, Shirayama M. Inductive asymmetric cell division: The WRM leads the way. Worm. 2013 Oct 01; 2(4):e26276. PMID: 24524013.
    15. Kim S, Ishidate T, Sharma R, Soto MC, Conte D, Mello CC, Shirayama M. Wnt and CDK-1 regulate cortical release of WRM-1/?-catenin to control cell division orientation in early Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):E918-27. PMID: 23431196.
      Citations: 16     Fields:    Translation:AnimalsCells
    16. Fievet BT, Rodriguez J, Naganathan S, Lee C, Zeiser E, Ishidate T, Shirayama M, Grill S, Ahringer J. Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy. Nat Cell Biol. 2013 Jan; 15(1):103-12. PMID: 23242217.
      Citations: 40     Fields:    Translation:AnimalsCells
    17. Lee HC, Gu W, Shirayama M, Youngman E, Conte D, Mello CC. C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts. Cell. 2012 Jul 06; 150(1):78-87. PMID: 22738724.
      Citations: 199     Fields:    Translation:AnimalsCells
    18. Shirayama M, Seth M, Lee HC, Gu W, Ishidate T, Conte D, Mello CC. piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline. Cell. 2012 Jul 06; 150(1):65-77. PMID: 22738726.
      Citations: 303     Fields:    Translation:AnimalsCells
    19. Conine CC, Batista PJ, Gu W, Claycomb JM, Chaves DA, Shirayama M, Mello CC. Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3588-93. PMID: 20133686.
      Citations: 127     Fields:    Translation:AnimalsCells
    20. Liu J, Maduzia LL, Shirayama M, Mello CC. NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division. Dev Biol. 2010 Mar 15; 339(2):366-73. PMID: 20059995.
      Citations: 29     Fields:    Translation:AnimalsCells
    21. Claycomb JM, Batista PJ, Pang KM, Gu W, Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, Conte D, Mello CC. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell. 2009 Oct 02; 139(1):123-34. PMID: 19804758.
      Citations: 247     Fields:    Translation:Animals
    22. Gu W, Shirayama M, Conte D, Vasale J, Batista PJ, Claycomb JM, Moresco JJ, Youngman EM, Keys J, Stoltz MJ, Chen CC, Chaves DA, Duan S, Kasschau KD, Fahlgren N, Yates JR, Mitani S, Carrington JC, Mello CC. Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell. 2009 Oct 23; 36(2):231-44. PMID: 19800275.
      Citations: 286     Fields:    Translation:AnimalsCells
    23. Shirayama M, Soto MC, Ishidate T, Kim S, Nakamura K, Bei Y, van den Heuvel S, Mello CC. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Curr Biol. 2006 Jan 10; 16(1):47-55. PMID: 16343905.
      Citations: 47     Fields:    Translation:AnimalsCells
    24. Nakamura K, Kim S, Ishidate T, Bei Y, Pang K, Shirayama M, Trzepacz C, Brownell DR, Mello CC. Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos. Genes Dev. 2005 Aug 01; 19(15):1749-54. PMID: 16077004.
      Citations: 43     Fields:    Translation:AnimalsCells
    25. Pang KM, Ishidate T, Nakamura K, Shirayama M, Trzepacz C, Schubert CM, Priess JR, Mello CC. The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos. Dev Biol. 2004 Jan 01; 265(1):127-39. PMID: 14697358.
      Citations: 27     Fields:    Translation:AnimalsCells
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