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Masaki Shirayama PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentRNA Therapeutics Institute
AddressUniversity of Massachusetts Medical School
373 Plantation Street
Worcester MA 01605
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentRNA Therapeutics Institute


    Collapse Biography 
    Collapse education and training
    University of Tokyo, Tokyo, , JapanPHDBiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ishidate T, Ozturk AR, Durning DJ, Sharma R, Shen EZ, Chen H, Seth M, Shirayama M, Mello CC. ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals. Mol Cell. 2018 May 17; 70(4):639-649.e6. PMID: 29775580.
      View in: PubMed
    2. Shen EZ, Chen H, Ozturk AR, Tu S, Shirayama M, Tang W, Ding YH, Dai SY, Weng Z, Mello CC. Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline. Cell. 2018 Feb 22; 172(5):937-951.e18. PMID: 29456082.
      View in: PubMed
    3. Tang W, Seth M, Tu S, Shen EZ, Li Q, Shirayama M, Weng Z, Mello CC. A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans. Dev Cell. 2018 03 26; 44(6):762-770.e3. PMID: 29456136.
      View in: PubMed
    4. Seth M, Shirayama M, Tang W, Shen EZ, Tu S, Lee HC, Weng Z, Mello CC. The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C. elegans. Cell Rep. 2018 Feb 27; 22(9):2254-2264. PMID: 29456100.
      View in: PubMed
    5. Gnazzo MM, Uhlemann EE, Villarreal AR, Shirayama M, Dominguez EG, Skop AR. The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4. Mol Biol Cell. 2016 Oct 15; 27(20):3052-3064. PMID: 27559134.
      View in: PubMed
    6. Elewa A, Shirayama M, Kaymak E, Harrison PF, Powell DR, Du Z, Chute CD, Woolf H, Yi D, Ishidate T, Srinivasan J, Bao Z, Beilharz TH, Ryder SP, Mello CC. POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA. Dev Cell. 2015 Jul 6; 34(1):108-18. PMID: 26096734.
      View in: PubMed
    7. Kim H, Ishidate T, Ghanta KS, Seth M, Conte D, Shirayama M, Mello CC. A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans. Genetics. 2014 Aug; 197(4):1069-80. PMID: 24879462.
      View in: PubMed
    8. Shirayama M, Stanney W, Gu W, Seth M, Mello CC. The Vasa Homolog RDE-12 engages target mRNA and multiple argonaute proteins to promote RNAi in C. elegans. Curr Biol. 2014 Apr 14; 24(8):845-51. PMID: 24684931.
      View in: PubMed
    9. Ishidate T, Elewa A, Kim S, Mello CC, Shirayama M. Divide and differentiate: CDK/Cyclins and the art of development. Cell Cycle. 2014; 13(9):1384-91. PMID: 24675894.
      View in: PubMed
    10. Seth M, Shirayama M, Gu W, Ishidate T, Conte D, Mello CC. The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression. Dev Cell. 2013 Dec 23; 27(6):656-63. PMID: 24360782.
      View in: PubMed
    11. Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D, Yates JR, Mello CC. Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans. Cell. 2013 Dec 19; 155(7):1532-44. PMID: 24360276.
      View in: PubMed
    12. Ishidate T, Kim S, Mello C, Shirayama M. Inductive asymmetric cell division: The WRM leads the way. Worm. 2013 Oct 1; 2(4):e26276. PMID: 24524013.
      View in: PubMed
    13. Kim S, Ishidate T, Sharma R, Soto MC, Conte D, Mello CC, Shirayama M. Wnt and CDK-1 regulate cortical release of WRM-1/ß-catenin to control cell division orientation in early Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A. 2013 Mar 5; 110(10):E918-27. PMID: 23431196.
      View in: PubMed
    14. Fievet BT, Rodriguez J, Naganathan S, Lee C, Zeiser E, Ishidate T, Shirayama M, Grill S, Ahringer J. Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy. Nat Cell Biol. 2013 Jan; 15(1):103-12. PMID: 23242217.
      View in: PubMed
    15. Shirayama M, Seth M, Lee HC, Gu W, Ishidate T, Conte D, Mello CC. piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline. Cell. 2012 Jul 6; 150(1):65-77. PMID: 22738726.
      View in: PubMed
    16. Lee HC, Gu W, Shirayama M, Youngman E, Conte D, Mello CC. C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts. Cell. 2012 Jul 6; 150(1):78-87. PMID: 22738724.
      View in: PubMed
    17. Conine CC, Batista PJ, Gu W, Claycomb JM, Chaves DA, Shirayama M, Mello CC. Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3588-93. PMID: 20133686.
      View in: PubMed
    18. Liu J, Maduzia LL, Shirayama M, Mello CC. NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division. Dev Biol. 2010 Mar 15; 339(2):366-73. PMID: 20059995.
      View in: PubMed
    19. Claycomb JM, Batista PJ, Pang KM, Gu W, Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, Conte D, Mello CC. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell. 2009 Oct 2; 139(1):123-34. PMID: 19804758.
      View in: PubMed
    20. Gu W, Shirayama M, Conte D, Vasale J, Batista PJ, Claycomb JM, Moresco JJ, Youngman EM, Keys J, Stoltz MJ, Chen CC, Chaves DA, Duan S, Kasschau KD, Fahlgren N, Yates JR, Mitani S, Carrington JC, Mello CC. Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell. 2009 Oct 23; 36(2):231-44. PMID: 19800275.
      View in: PubMed
    21. Shirayama M, Soto MC, Ishidate T, Kim S, Nakamura K, Bei Y, van den Heuvel S, Mello CC. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Curr Biol. 2006 Jan 10; 16(1):47-55. PMID: 16343905.
      View in: PubMed
    22. Nakamura K, Kim S, Ishidate T, Bei Y, Pang K, Shirayama M, Trzepacz C, Brownell DR, Mello CC. Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos. Genes Dev. 2005 Aug 1; 19(15):1749-54. PMID: 16077004.
      View in: PubMed
    23. Pang KM, Ishidate T, Nakamura K, Shirayama M, Trzepacz C, Schubert CM, Priess JR, Mello CC. The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos. Dev Biol. 2004 Jan 1; 265(1):127-39. PMID: 14697358.
      View in: PubMed
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