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The dual topoisomerase inhibitor A35 preferentially and specially targets topoisomerase 2a by enhancing pre-strand and post-strand cleavage and inhibiting DNA religation.

Zhao W, Jiang G, Bi C, Li Y, Liu J, Ye C, He H, Li L, Song D, Shao R. The dual topoisomerase inhibitor A35 preferentially and specially targets topoisomerase 2a by enhancing pre-strand and post-strand cleavage and inhibiting DNA religation. Oncotarget. 2015 Nov 10; 6(35):37871-94.

View in: PubMed