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Javier Elbio Irazoqui PhD

TitleAssociate Professor
Endowed TitleMarcellette G. Williams Scholar
InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
368 Plantation Street
Worcester MA 01605
Phone774-455-3797
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Microbial Dynamics

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program


    Collapse Biography 
    Collapse education and training
    Duke University, Durham, NC, United StatesPHDMolecular Cancer Biology
    National University of Rosario, ArgentinaB.S.03/1997Biotechnology
    Harvard Medical School, Boston, MAPostdoctoral Fellow09/2009Innate Immunity
    Collapse awards and honors
    2020 - 2025Dr. Marcellette G. Williams Distinguished Scholar, UMass Medical School

    Collapse Overview 
    Collapse Summary
    Focus: Microbiota-gut-brain axis; mucosal innate immunity; staphylococcus aureus; transcriptional regulation of host defense; autophagy; SARS-CoV-2 interactions with human lung cells
    Collapse overview

    Dr. Javier E. Irazoqui (he/him/his) was born in Santa Fe, Argentina and was raised in Santa Fe and Minneapolis, MN. Dr. Irazoqui received his BS from the National University of Rosario, Argentina in 1997. He received his PhD in Cell and Molecular Biology from Duke University in 2003 for his work on Rho G-proteins and actin remodeling in yeast. He pursued his postdoctoral research in host-pathogen interactions with Dr. Fred Ausubel in the Department of Molecular Biology of the Massachusetts General Hospital and the Department of Genetics of Harvard Medical School. Dr. Irazoqui has led his independent laboratory since 2009, first in the Department of Pediatrics and later in the Center for the Study of Inflammatory Bowel Disease (CSIBD), both at MGH. He lectured at Harvard University and Harvard Medical School. In August 2016 Dr. Irazoqui's laboratory relocated to the Department of Microbiology and Physiological Systems of the University of Massachusetts Medical School, where he is affiliated with the Program in Innate Immunity and the Neuroscience Program. His laboratory's research focuses on mechanisms of host-microbe interactions in health and disease, with special emphasis on neural regulation of epithelial host defense and the microbiota-gut-brain axis. Their research in bacterial pathogenesis and host defense is supported by the National Institutes of Health and by the National Science Foundation. More recently, their research on COVID-19 and SARS-CoV-2 mechanisms of pathogenesis received support from the UMass Medical School COVID-19/Pandemic Research Fund. Dr. Irazoqui actively works for social justice in STEM, promoting Diversity, Equity, and Inclusion through service within UMass and without. Dr. Irazoqui encourages Learners and Trainees of all stages to reach out to him for mentorship, advice, and support, especially for BIPOC individuals and Women in Science.


    Collapse Rotation Projects

    1. Cloning of metazoan PC-PLC
    2. Screening for Methicillin Resistant S. aureus (MRSA) virulence determinants
    3. Screening for Salmonella virulence determinants
    4. Genetic and cell biological analysis of neural-immune communication in vivo
    5. Control of gene expression using intestinal organoids
    6. Development of CRISPR genome-editing strategies
    7. Regulatory and cell biological functions of SARS-CoV-2 open reading frames


    Collapse Post Docs

    Khursheed Wani, PhD



    Collapse Research 
    Collapse research activities and funding
    R01GM101056     (IRAZOQUI, JAVIER ELBIO)Apr 1, 2012 - Jul 31, 2021
    NIH
    Nervous system control of intestinal host defense mediated by TFEB
    Role: Principal Investigator
         (Irazoqui)Aug 1, 2013 - Jul 31, 2016
    NSF
    Neuronal Wnt and host defense in C. elegans
    Role: PI

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wani KA, Goswamy D, Taubert S, Ratnappan R, Ghazi A, Irazoqui JE. NHR-49/PPAR-? and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase. Elife. 2021 05 12; 10. PMID: 33978570.
      Citations: 4     Fields:    Translation:AnimalsCells
    2. Najibi M, Honwad HH, Moreau JA, Becker SM, Irazoqui JE. A NOVEL NOX/PHOX-CD38-NAADP-TFEB AXIS IMPORTANT FOR MACROPHAGE ACTIVATION DURING BACTERIAL PHAGOCYTOSIS. Autophagy. 2022 Jan; 18(1):124-141. PMID: 33818279.
      Citations:    Fields:    Translation:Cells
    3. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cantí C, Cao B, Caraglia M, Caramés B, Carchman EH, Cardenal-Muñoz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382. PMID: 33634751.
      Citations: 271     Fields:    Translation:HumansAnimalsCells
    4. Goswamy D, Irazoqui JE. A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans. Curr Opin Immunol. 2021 02; 68:9-20. PMID: 32898751.
      Citations: 2     Fields:    Translation:Animals
    5. Irazoqui JE. Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation. Trends Immunol. 2020 02; 41(2):157-171. PMID: 31959514.
      Citations: 9     Fields:    Translation:Humans
    6. Wani KA, Goswamy D, Irazoqui JE. Nervous system control of intestinal host defense in C. elegans. Curr Opin Neurobiol. 2020 06; 62:1-9. PMID: 31790812.
      Citations: 10     Fields:    Translation:Animals
    7. Wani KA, Goswamy D, Irazoqui JE. A Nutrition-Longevity Tradeoff Enforced by Innate Immunity. Mol Cell. 2019 06 06; 74(5):864-865. PMID: 31173721.
      Citations: 1     Fields:    Translation:Animals
    8. Labed SA, Wani KA, Jagadeesan S, Hakkim A, Najibi M, Irazoqui JE. Intestinal Epithelial Wnt Signaling Mediates Acetylcholine-Triggered Host Defense against Infection. Immunity. 2018 05 15; 48(5):963-978.e3. PMID: 29768179.
      Citations: 26     Fields:    Translation:AnimalsCells
    9. Murano T, Najibi M, Paulus GLC, Adiliaghdam F, Valencia-Guerrero A, Selig M, Wang X, Jeffrey K, Xavier RJ, Lassen KG, Irazoqui JE. Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo. Sci Rep. 2017 10 24; 7(1):13938. PMID: 29066772.
      Citations: 10     Fields:    Translation:AnimalsCells
    10. Najibi M, Labed SA, Visvikis O, Irazoqui JE. An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Rep. 2016 05 24; 15(8):1728-42. PMID: 27184844.
      Citations: 29     Fields:    Translation:AnimalsCells
    11. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      Citations: 2503     Fields:    Translation:HumansAnimals
    12. Srinivasa S, Suresh C, Mottla J, Hamarneh SR, Irazoqui JE, Frontera W, Torriani M, Stanley T, Makimura H. FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth hormone. Growth Horm IGF Res. 2016 Feb; 26:36-41. PMID: 26774404.
      Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
    13. Irazoqui JE. Why worms watch their hemidesmosomes and why you should, too. Immunity. 2015 Feb 17; 42(2):206-208. PMID: 25692695.
      Citations:    Fields:    Translation:HumansAnimals
    14. Irazoqui JE. DAF-tly depart stinky situations with elegans. Cell Host Microbe. 2014 Nov 12; 16(5):553-5. PMID: 25525785.
      Citations:    Fields:    Translation:AnimalsCells
    15. Hamarneh SR, Murphy CA, Shih CW, Frontera W, Torriani M, Irazoqui JE, Makimura H. Relationship between serum IGF-1 and skeletal muscle IGF-1 mRNA expression to phosphocreatine recovery after exercise in obese men with reduced GH. J Clin Endocrinol Metab. 2015 Feb; 100(2):617-25. PMID: 25375982.
      Citations: 6     Fields:    Translation:HumansCells
    16. Visvikis O, Ihuegbu N, Labed SA, Luhachack LG, Alves AF, Wollenberg AC, Stuart LM, Stormo GD, Irazoqui JE. Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. Immunity. 2014 Jun 19; 40(6):896-909. PMID: 24882217.
      Citations: 126     Fields:    Translation:AnimalsCells
    17. Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Klisch TJ, Wollenberg AC, Di Bernardo D, Chan L, Irazoqui JE, Ballabio A. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol. 2013 Jun; 15(6):647-58. PMID: 23604321.
      Citations: 432     Fields:    Translation:HumansAnimalsCells
    18. Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE, Dillin A, Hansen M. The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun. 2013; 4:2267. PMID: 23925298.
      Citations: 204     Fields:    Translation:AnimalsCells
    19. Brown S, Xia G, Luhachack LG, Campbell J, Meredith TC, Chen C, Winstel V, Gekeler C, Irazoqui JE, Peschel A, Walker S. Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids. Proc Natl Acad Sci U S A. 2012 Nov 13; 109(46):18909-14. PMID: 23027967.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    20. Luhachack LG, Visvikis O, Wollenberg AC, Lacy-Hulbert A, Stuart LM, Irazoqui JE. EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways. PLoS Pathog. 2012; 8(7):e1002798. PMID: 22792069.
      Citations: 14     Fields:    Translation:AnimalsCells
    21. Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE. An image analysis toolbox for high-throughput C. elegans assays. Nat Methods. 2012 Apr 22; 9(7):714-6. PMID: 22522656.
      Citations: 74     Fields:    Translation:Animals
    22. Irazoqui JE. Transparent worms help survey the fortress of innate immunity. Virulence. 2011 Mar-Apr; 2(2):83-5. PMID: 21460640.
      Citations:    Fields:    Translation:AnimalsCells
    23. Irazoqui JE, Troemel ER, Feinbaum RL, Luhachack LG, Cezairliyan BO, Ausubel FM. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. PLoS Pathog. 2010 Jul 01; 6:e1000982. PMID: 20617181.
      Citations: 143     Fields:    Translation:HumansAnimalsCells
    24. Irazoqui JE, Ausubel FM. 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Caenorhabditis elegans as a model to study tissues involved in host immunity and microbial pathogenesis. Clin Exp Immunol. 2010 Apr; 160(1):48-57. PMID: 20415851.
      Citations: 16     Fields:    Translation:AnimalsCells
    25. Irazoqui JE, Urbach JM, Ausubel FM. Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates. Nat Rev Immunol. 2010 Jan; 10(1):47-58. PMID: 20029447.
      Citations: 187     Fields:    Translation:Animals
    26. Irazoqui JE, Ng A, Xavier RJ, Ausubel FM. Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17469-74. PMID: 18981407.
      Citations: 50     Fields:    Translation:AnimalsCells
    27. Irazoqui JE, Howell AS, Theesfeld CL, Lew DJ. Opposing roles for actin in Cdc42p polarization. Mol Biol Cell. 2005 Mar; 16(3):1296-304. PMID: 15616194.
      Citations: 34     Fields:    Translation:AnimalsCells
    28. Irazoqui JE, Gladfelter AS, Lew DJ. Cdc42p, GTP hydrolysis, and the cell's sense of direction. Cell Cycle. 2004 Jul; 3(7):861-4. PMID: 15190213.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    29. Irazoqui JE, Lew DJ. Polarity establishment in yeast. J Cell Sci. 2004 May 01; 117(Pt 11):2169-71. PMID: 15126618.
      Citations: 27     Fields:    Translation:Animals
    30. Irazoqui JE, Gladfelter AS, Lew DJ. Scaffold-mediated symmetry breaking by Cdc42p. Nat Cell Biol. 2003 Dec; 5(12):1062-70. PMID: 14625559.
      Citations: 122     Fields:    Translation:AnimalsCells
    31. Bose I, Irazoqui JE, Moskow JJ, Bardes ES, Zyla TR, Lew DJ. Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p. J Biol Chem. 2001 Mar 09; 276(10):7176-86. PMID: 11113154.
      Citations: 100     Fields:    Translation:Cells
    32. Theesfeld CL, Irazoqui JE, Bloom K, Lew DJ. The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle. J Cell Biol. 1999 Sep 06; 146(5):1019-32. PMID: 10477756.
      Citations: 45     Fields:    Translation:AnimalsCells
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