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Javier Elbio Irazoqui PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMicrobiology and Physiological Systems
AddressUniversity of Massachusetts Medical School
368 Plantation Street
Worcester MA 01605
Phone774-455-3797
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience


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    Collapse Biography 
    Collapse education and training
    Duke University, Durham, NC, United StatesPHDMolecular Cancer Biology
    National University of Rosario, ArgentinaB.S.03/1997Biotechnology
    Harvard Medical School, Boston, MAPostdoctoral Fellow09/2009Innate Immunity
    Collapse awards and honors
    2020 - 2025Dr. Marcellette G. Williams Distinguished Scholar, UMass Medical School

    Collapse Overview 
    Collapse overview

    Dr. Javier E. Irazoqui (he/him/his) was born in Santa Fe, Argentina and was raised in Santa Fe and Minneapolis, MN. Dr. Irazoqui received his BS from the National University of Rosario, Argentina in 1997. He received his PhD in Cell and Molecular Biology from Duke University in 2003 for his work on Rho G-proteins and actin remodeling in yeast. He pursued his postdoctoral research in host-pathogen interactions with Dr. Fred Ausubel in the Department of Molecular Biology of the Massachusetts General Hospital and the Department of Genetics of Harvard Medical School. Dr. Irazoqui has led his independent laboratory since 2009, first in the Department of Pediatrics and later in the Center for the Study of Inflammatory Bowel Disease (CSIBD), both at MGH. He lectured at Harvard University and Harvard Medical School. In August 2016 Dr. Irazoqui's laboratory relocated to the Department of Microbiology and Physiological Systems of the University of Massachusetts Medical School, where he is affiliated with the Program in Innate Immunity and the Neuroscience Program. His laboratory's research focuses on mechanisms of host-microbe interactions in health and disease, with special emphasis on neural regulation of epithelial host defense and the microbiota-gut-brain axis. Their research in bacterial pathogenesis and host defense is supported by the National Institutes of Health and by the National Science Foundation. More recently, their research on COVID-19 and SARS-CoV-2 mechanisms of pathogenesis received support from the UMass Medical School COVID-19/Pandemic Research Fund. Dr. Irazoqui actively works for social justice in STEM, promoting Diversity, Equity, and Inclusion through service within UMass and without. Dr. Irazoqui encourages Learners and Trainees of all stages to reach out to him for mentorship, advice, and support, especially for BIPOC individuals and Women in Science.



    Collapse Rotation Projects

    1. Cloning of metazoan PC-PLC
    2. Screening for Methicillin Resistant S. aureus (MRSA) virulence determinants
    3. Screening for Salmonella virulence determinants
    4. Genetic and cell biological analysis of neural-immune communication in vivo
    5. Control of gene expression using intestinal organoids
    6. Development of CRISPR genome-editing strategies
    7. Regulatory and cell biological functions of SARS-CoV-2 open reading frames



    Collapse Post Docs

    Khursheed Wani, PhD




    Collapse Research 
    Collapse research activities and funding
    R01GM101056     (IRAZOQUI, JAVIER ELBIO)Apr 1, 2012 - Jul 31, 2021
    NIH
    Nervous system control of intestinal host defense mediated by TFEB
    Role: Principal Investigator
         (Irazoqui)Aug 1, 2013 - Jul 31, 2016
    NSF
    Neuronal Wnt and host defense in C. elegans
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Goswamy D, Irazoqui JE. A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans. Curr Opin Immunol. 2020 Sep 05; 68:9-20. PMID: 32898751.
      View in: PubMed
    2. Irazoqui JE. Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation. Trends Immunol. 2020 Jan 17. PMID: 31959514.
      View in: PubMed
    3. Wani KA, Goswamy D, Irazoqui JE. Nervous system control of intestinal host defense in C. elegans. Curr Opin Neurobiol. 2019 Nov 28; 62:1-9. PMID: 31790812.
      View in: PubMed
    4. Wani KA, Goswamy D, Irazoqui JE. A Nutrition-Longevity Tradeoff Enforced by Innate Immunity. Mol Cell. 2019 Jun 06; 74(5):864-865. PMID: 31173721.
      View in: PubMed
    5. Labed SA, Wani KA, Jagadeesan S, Hakkim A, Najibi M, Irazoqui JE. Intestinal Epithelial Wnt Signaling Mediates Acetylcholine-Triggered Host Defense against Infection. Immunity. 2018 May 15; 48(5):963-978.e4. PMID: 29768179.
      View in: PubMed
    6. Murano T, Najibi M, Paulus GLC, Adiliaghdam F, Valencia-Guerrero A, Selig M, Wang X, Jeffrey K, Xavier RJ, Lassen KG, Irazoqui JE. Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo. Sci Rep. 2017 Oct 24; 7(1):13938. PMID: 29066772.
      View in: PubMed
    7. Najibi M, Labed SA, Visvikis O, Irazoqui JE. An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Rep. 2016 May 24; 15(8):1728-42. PMID: 27184844.
      View in: PubMed
    8. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    9. Srinivasa S, Suresh C, Mottla J, Hamarneh SR, Irazoqui JE, Frontera W, Torriani M, Stanley T, Makimura H. FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth hormone. Growth Horm IGF Res. 2016 Feb; 26:36-41. PMID: 26774404.
      View in: PubMed
    10. Irazoqui JE. Why worms watch their hemidesmosomes and why you should, too. Immunity. 2015 Feb 17; 42(2):206-8. PMID: 25692695.
      View in: PubMed
    11. Irazoqui JE. DAF-tly depart stinky situations with elegans. Cell Host Microbe. 2014 Nov 12; 16(5):553-5. PMID: 25525785.
      View in: PubMed
    12. Hamarneh SR, Murphy CA, Shih CW, Frontera W, Torriani M, Irazoqui JE, Makimura H. Relationship between serum IGF-1 and skeletal muscle IGF-1 mRNA expression to phosphocreatine recovery after exercise in obese men with reduced GH. J Clin Endocrinol Metab. 2015 Feb; 100(2):617-25. PMID: 25375982.
      View in: PubMed
    13. Visvikis O, Ihuegbu N, Labed SA, Luhachack LG, Alves AM, Wollenberg AC, Stuart LM, Stormo GD, Irazoqui JE. Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. Immunity. 2014 Jun 19; 40(6):896-909. PMID: 24882217.
      View in: PubMed
    14. Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Klisch TJ, Wollenberg AC, Di Bernardo D, Chan L, Irazoqui JE, Ballabio A. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol. 2013 Jun; 15(6):647-58. PMID: 23604321.
      View in: PubMed
    15. Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE, Dillin A, Hansen M. The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun. 2013; 4:2267. PMID: 23925298.
      View in: PubMed
    16. Brown S, Xia G, Luhachack LG, Campbell J, Meredith TC, Chen C, Winstel V, Gekeler C, Irazoqui JE, Peschel A, Walker S. Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids. Proc Natl Acad Sci U S A. 2012 Nov 13; 109(46):18909-14. PMID: 23027967.
      View in: PubMed
    17. Luhachack LG, Visvikis O, Wollenberg AC, Lacy-Hulbert A, Stuart LM, Irazoqui JE. EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways. PLoS Pathog. 2012; 8(7):e1002798. PMID: 22792069.
      View in: PubMed
    18. Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE. An image analysis toolbox for high-throughput C. elegans assays. Nat Methods. 2012 Apr 22; 9(7):714-6. PMID: 22522656.
      View in: PubMed
    19. Irazoqui JE. Transparent worms help survey the fortress of innate immunity. Virulence. 2011 Mar-Apr; 2(2):83-5. PMID: 21460640.
      View in: PubMed
    20. Irazoqui JE, Troemel ER, Feinbaum RL, Luhachack LG, Cezairliyan BO, Ausubel FM. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. PLoS Pathog. 2010 Jul 01; 6:e1000982. PMID: 20617181.
      View in: PubMed
    21. Irazoqui JE, Ausubel FM. 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Caenorhabditis elegans as a model to study tissues involved in host immunity and microbial pathogenesis. Clin Exp Immunol. 2010 Apr; 160(1):48-57. PMID: 20415851.
      View in: PubMed
    22. Irazoqui JE, Urbach JM, Ausubel FM. Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates. Nat Rev Immunol. 2010 Jan; 10(1):47-58. PMID: 20029447.
      View in: PubMed
    23. Irazoqui JE, Ng A, Xavier RJ, Ausubel FM. Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17469-74. PMID: 18981407.
      View in: PubMed
    24. Irazoqui JE, Howell AS, Theesfeld CL, Lew DJ. Opposing roles for actin in Cdc42p polarization. Mol Biol Cell. 2005 Mar; 16(3):1296-304. PMID: 15616194.
      View in: PubMed
    25. Irazoqui JE, Gladfelter AS, Lew DJ. Cdc42p, GTP hydrolysis, and the cell's sense of direction. Cell Cycle. 2004 Jul; 3(7):861-4. PMID: 15190213.
      View in: PubMed
    26. Irazoqui JE, Lew DJ. Polarity establishment in yeast. J Cell Sci. 2004 May 1; 117(Pt 11):2169-71. PMID: 15126618.
      View in: PubMed
    27. Irazoqui JE, Gladfelter AS, Lew DJ. Scaffold-mediated symmetry breaking by Cdc42p. Nat Cell Biol. 2003 Dec; 5(12):1062-70. PMID: 14625559.
      View in: PubMed
    28. Bose I, Irazoqui JE, Moskow JJ, Bardes ES, Zyla TR, Lew DJ. Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p. J Biol Chem. 2001 Mar 9; 276(10):7176-86. PMID: 11113154.
      View in: PubMed
    29. Theesfeld CL, Irazoqui JE, Bloom K, Lew DJ. The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle. J Cell Biol. 1999 Sep 6; 146(5):1019-32. PMID: 10477756.
      View in: PubMed
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