Header Logo

Jae-Hyuck Shim PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
364 Plantation Street LRB280
Worcester MA 01605
Phone508-856-6245
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionRheumatology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program


    Collapse Biography 
    Collapse education and training
    Yonsei University, Seoul, , Korea, Republic ofBSBiotechnology
    Yonsei University, Seoul, , Korea, Republic ofMSBiotechnology
    Yale University School of Medicine, New Haven, CT, United StatesPHDPhilosophy
    Harvard School of Public Health, Boston, MAPostdocOsteoimmunology
    Harvard School of Public Health, Boston, MAInstructorOsteoimmunology
    Collapse awards and honors
    2014ASBMR John Haddad Young Investigator Award, Weill Cornell Medicine
    2013ASBMR Harold M. Frost Young Investigator Award, Weill Cornell Medicine
    2011 - 2012NRSA Fellowship, Harvard School of Medicine
    2008 - 2011Arthritis Foundation Postdoctoral Fellowship, Harvard School of Public Health
    2004 - 2015Richard K. Gershon Pre-and/or Postdoctoral Fellowship, Yale Medical School

    Collapse Overview 
    Collapse overview

    Bone mass reflects the coupled balance of activity of osteoblasts to synthesize and osteoclasts to degrade bone matrix.  Coupling of the activity between these two lineages is required for balance in bone remodeling, and dysregulation of this process is a major mechanism in the pathogenesis of many of human skeletal disorders, such as osteoporosis, inflammation-induced bone loss, and periodontitis. Additionally, osteoblast differentiation capacity of skeletal stem cells must be tightly controlled, as inadequate bone formation results in low bone mass, skeletal fragility, and bone healing defect, while over-exuberant osteogenesis results in extra-bone formation in the soft connective tissues, such as trauma-induced heterotopic ossification and fibrodysplasia ossificans progressiva by a genetic mutation.

    Understanding the molecular mechanisms that regulate these activities is a key to developing improved therapeutics to treat human skeletal disorders. To this end, we took advantage of an unbiased high-throughput screens to identify new proteins that control osteoblast and osteoclast commitment, differentiation, and activation under pathological conditions. Alternatively, using the premise that tissues emerging from similar points during vertebrate evolution may share common intracellular signaling networks to guide their activity, we have sought to leverage our extensive knowledge obtained from the immune system to understand the mechanism in which bone cells are regulated. 

    For the above proteins that we identified, we have developed sophisticated in vivo gene transfer technologies. In these technologies, nanoparticles, liposomes, exosomes, or adeno-associated virus (AAV) are modified to home to the bone surface and deliver RNA interference and/or healthy gene to osteoblasts and osteoclasts, thus affecting their activity. The impact of this work could have far reaching effects. If the molecular pathways regulating osteoclast/osteoblast coupling can be better understood, then targeted approaches to promote osteoblast activity via systemic infusion or local implantation could be used as a therapeutic approach for patients suffering with low bone density disorders, such as osteoporosis, bone fracture healing defect, or critical-sized bone defect. Furthermore, these technologies can be used to directly correct a genetic mutation in the body in order to treat and/or cure skeletal rare diseases with monogenic mutations, such as fibrodysplasia ossificans progressiva or osteogenesis imperfecta.

     


    Collapse Post Docs


    Jungmin Kim



    Zheni Stavre



    Chujiao Lin



    Sachin Ramdas



    Aijaz John



    Yeon-Suk Yang



    Eun-Hye Son



    Zhihao Chen



    Tadatoshi Sato


    Collapse webpage

    Collapse Research 
    Collapse research activities and funding
         (Jae-hyuck Shim)Mar 19, 2020 - Mar 18, 2022
    AAVAA Therapeutics
    Development of novel gene therapeutics for bone fracture and graft defect
    Role Description: The major goal of this project is to develop new gene therapeutics that can manipulate gene expression in bone cells, including osteoblasts and osteoclasts using bone-targeting adeno-associated virus in order to promote bone healing.
    Role: Multi-PI

         (Jae-hyuck Shim)Jul 1, 2020 - Jun 30, 2022
    international FOP foundation
    Development of novel gene therapy for Fibrodysplasia Ossificans Progressiva
    Role Description: The major goal of this project is to develop new gene therapeutics that can manipulate expression of human ACVR1 in osteoblast lineage cells, in order to prevent and/or suppress the progress of heterotopic ossification
    Role: Multi-PI

         (Jae-hyuck Shim)Sep 1, 2020 - Aug 31, 2022
    AAVAA Therapeutics
    Development of novel gene therapeutics for skeletal rare diseases
    Role Description: The major goal of this project is to develop new gene therapy for fibrodysplasia ossificans progressive and osteogenesis imperfecta.

    R21AR077557     (Jae-hyuck Shim)Jul 1, 2021 - Jun 30, 2023
    NIH/NIAMS
    A novel bone-targeting AAV-mediated gene therapy to promote bone formation in osteoporosis
    Role Description: The major goal of this project is to develop a novel bone anabolic gene therapy to treat osteoporosis
    Role: PI

    R01AR078230     (Jae-hyuck Shim)Sep 1, 2021 - Aug 31, 2026
    NIH/NIAMS
    Novel approaches to promote healing of bone loss in inflammatory arthritis
    Role Description: The major goal of this project is to provide proof-of-principle that SHN3 inhibition can augment bone formation at sites of inflammation-induced bone loss in mouse models, determine the mechanism by which SHN3 knock down protects from suppression of osteoblast differentiation by RA-derived cytokines, and test the ability of genetically manipulated mesenchymal stem cells to repair inflammation-induced bone loss.
    Role: Multi-PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Eekhoff EMW, de Ruiter RD, Smilde BJ, Schoenmaker T, de Vries TJ, Netelenbos C, Hsiao EC, Scott C, Haga N, Grunwald Z, De Cunto CL, Di Rocco M, Delai P, Diecidue R, Madhuri V, Cho TJ, Morhart R, Friedman C, Zasloff M, Pals G, Shim JH, Gao G, Kaplan F, Pignolo RJ, Micha D. Gene therapy for Fibrodysplasia Ossificans Progressiva (FOP): feasibility and obstacles. Hum Gene Ther. 2022 05 02. PMID: 35502479.
      Citations:    Fields:    
    2. Greenblatt MB, Shim JH, Bok S, Kim JM. The Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Pathway in Osteoblasts. J Bone Metab. 2022 Feb; 29(1):1-15. PMID: 35325978.
      Citations:    
    3. Kim JM, Yang YS, Xie J, Lee O, Kim J, Hong J, Boldyreff B, Filhol O, Chun H, Greenblatt MB, Gao G, Shim JH. Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes. Cell Death Differ. 2022 Aug; 29(8):1625-1638. PMID: 35169297.
      Citations:    Fields:    
    4. Chaugule S, Kim JM, Yang YS, Knobeloch KP, He X, Shim JH. Deubiquitinating Enzyme USP8 Is Essential for Skeletogenesis by Regulating Wnt Signaling. Int J Mol Sci. 2021 Sep 24; 22(19). PMID: 34638628.
      Citations:    Fields:    Translation:AnimalsCells
    5. Sun J, Shin DY, Eiseman M, Yallowitz AR, Li N, Lalani S, Li Z, Cung M, Bok S, Debnath S, Marquez SJ, White TE, Khan AG, Lorenz IC, Shim JH, Lee FS, Xu R, Greenblatt MB. SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts. Nat Commun. 2021 07 29; 12(1):4611. PMID: 34326333.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    6. Yoon DS, Lee KM, Cho S, Ko EA, Kim J, Jung S, Shim JH, Gao G, Park KH, Lee JW. Cellular and Tissue Selectivity of AAV Serotypes for Gene Delivery to Chondrocytes and Cartilage. Int J Med Sci. 2021; 18(15):3353-3360. PMID: 34522160.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    7. Park Y, Cheong E, Kwak JG, Carpenter R, Shim JH, Lee J. Trabecular bone organoid model for studying the regulation of localized bone remodeling. Sci Adv. 2021 01; 7(4). PMID: 33523925.
      Citations: 5     Fields:    Translation:Cells
    8. Bok S, Shin DY, Yallowitz AR, Eiseman M, Cung M, Xu R, Li N, Sun J, Williams AL, Scott JE, Su B, Shim JH, Greenblatt MB. MEKK2 mediates aberrant ERK activation in neurofibromatosis type I. Nat Commun. 2020 11 11; 11(1):5704. PMID: 33177525.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    9. Kim JM, Lin C, Stavre Z, Greenblatt MB, Shim JH. Osteoblast-Osteoclast Communication and Bone Homeostasis. Cells. 2020 09 10; 9(9). PMID: 32927921.
      Citations: 71     Fields:    Translation:HumansCells
    10. Li Z, Oh H, Cung M, Marquez SJ, Sun J, Hammad H, Janssens S, Pouliot P, Lambrecht BN, Yang YS, Shim JH, Greenblatt MB. TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization. Biochem Biophys Res Commun. 2020 10 22; 531(4):497-502. PMID: 32807497.
      Citations: 4     Fields:    Translation:AnimalsCells
    11. Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH. A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Nat Commun. 2020 05 08; 11(1):2289. PMID: 32385263.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    12. Yang YS, Xie J, Chaugule S, Wang D, Kim JM, Kim J, Tai PWL, Seo SK, Gravallese E, Gao G, Shim JH. Bone-Targeting AAV-Mediated Gene Silencing in Osteoclasts for Osteoporosis Therapy. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:922-935. PMID: 32405514.
      Citations:    
    13. Kim MJ, Min Y, Shim JH, Chun E, Lee KY. CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1. Front Immunol. 2019; 10:2203. PMID: 31620128.
      Citations: 9     Fields:    Translation:HumansCells
    14. Yang YS, Xie J, Wang D, Kim JM, Tai PWL, Gravallese E, Gao G, Shim JH. Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis. Nat Commun. 2019 07 04; 10(1):2958. PMID: 31273195.
      Citations: 20     Fields:    Translation:AnimalsCells
    15. Kim JM, Yang YS, Park KH, Oh H, Greenblatt MB, Shim JH. The ERK MAPK Pathway Is Essential for Skeletal Development and Homeostasis. Int J Mol Sci. 2019 Apr 12; 20(8). PMID: 31013682.
      Citations: 29     Fields:    Translation:AnimalsCells
    16. Son F, Umphred-Wilson K, Shim JH, Adoro S. Assessment of ESCRT Protein CHMP5 Activity on Client Protein Ubiquitination by Immunoprecipitation and Western Blotting. Methods Mol Biol. 2019; 1998:219-226. PMID: 31250305.
      Citations: 3     Fields:    Translation:HumansCells
    17. Debnath S, Yallowitz AR, McCormick J, Lalani S, Zhang T, Xu R, Li N, Liu Y, Yang YS, Eiseman M, Shim JH, Hameed M, Healey JH, Bostrom MP, Landau DA, Greenblatt MB. Discovery of a periosteal stem cell mediating intramembranous bone formation. Nature. 2018 10; 562(7725):133-139. PMID: 30250253.
      Citations: 156     Fields:    Translation:HumansAnimalsCells
    18. Xu R, Yallowitz A, Qin A, Wu Z, Shin DY, Kim JM, Debnath S, Ji G, Bostrom MP, Yang X, Zhang C, Dong H, Kermani P, Lalani S, Li N, Liu Y, Poulos MG, Wach A, Zhang Y, Inoue K, Di Lorenzo A, Zhao B, Butler JM, Shim JH, Glimcher LH, Greenblatt MB. Targeting skeletal endothelium to ameliorate bone loss. Nat Med. 2018 06; 24(6):823-833. PMID: 29785024.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    19. Kim Y, Zhang Z, Shim JH, Lee TS, Tung CH. A cell surface clicked navigation system to direct specific bone targeting. Bioorg Med Chem. 2018 02 01; 26(3):758-764. PMID: 29306547.
      Citations:    Fields:    Translation:HumansAnimalsCells
    20. Shim JH, Stavre Z, Gravallese EM. Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications. Calcif Tissue Int. 2018 05; 102(5):533-546. PMID: 29204672.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    21. Xu R, Zhang C, Shin DY, Kim JM, Lalani S, Li N, Yang YS, Liu Y, Eiseman M, Davis RJ, Shim JH, Greenblatt MB. c-Jun N-Terminal Kinases (JNKs) Are Critical Mediators of Osteoblast Activity In Vivo. J Bone Miner Res. 2017 Sep; 32(9):1811-1815. PMID: 28561373.
      Citations: 19     Fields:    Translation:AnimalsCells
    22. Adoro S, Park KH, Bettigole SE, Lis R, Shin HR, Seo H, Kim JH, Knobeloch KP, Shim JH, Glimcher LH. Post-translational control of T cell development by the ESCRT protein CHMP5. Nat Immunol. 2017 Jul; 18(7):780-790. PMID: 28553951.
      Citations: 10     Fields:    Translation:AnimalsCells
    23. Poulos MG, Ramalingam P, Gutkin MC, Kleppe M, Ginsberg M, Crowley MJP, Elemento O, Levine RL, Rafii S, Kitajewski J, Greenblatt MB, Shim JH, Butler JM. Endothelial-specific inhibition of NF-?B enhances functional haematopoiesis. Nat Commun. 2016 12 21; 7:13829. PMID: 28000664.
      Citations: 20     Fields:    Translation:AnimalsCells
    24. Min Y, Wi SM, Kang JA, Yang T, Park CS, Park SG, Chung S, Shim JH, Chun E, Lee KY. Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6. Cell Death Dis. 2016 07 28; 7(7):e2313. PMID: 27468689.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    25. Greenblatt MB, Shin DY, Oh H, Lee KY, Zhai B, Gygi SP, Lotinun S, Baron R, Liu D, Su B, Glimcher LH, Shim JH. MEKK2 mediates an alternative ?-catenin pathway that promotes bone formation. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):E1226-35. PMID: 26884171.
      Citations: 29     Fields:    Translation:AnimalsCells
    26. Moon G, Kim J, Min Y, Wi SM, Shim JH, Chun E, Lee KY. Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling. Cell Signal. 2015 Dec; 27(12):2524-33. PMID: 26432169.
      Citations: 15     Fields:    Translation:HumansCells
    27. Oh DS, Koch A, Eisig S, Kim SG, Kim YH, Kim DG, Shim JH. Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect. J Vis Exp. 2015 Sep 11; (103). PMID: 26380953.
      Citations: 1     Fields:    Translation:HumansCells
    28. Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, Ghosh S, Shim JH. CHMP5 controls bone turnover rates by dampening NF-?B activity in osteoclasts. J Exp Med. 2015 Jul 27; 212(8):1283-301. PMID: 26195726.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    29. Greenblatt MB, Kim JM, Oh H, Park KH, Choo MK, Sano Y, Tye CE, Skobe Z, Davis RJ, Park JM, Bei M, Glimcher LH, Shim JH. p38? MAPK is required for tooth morphogenesis and enamel secretion. J Biol Chem. 2015 Jan 02; 290(1):284-95. PMID: 25406311.
      Citations: 10     Fields:    Translation:AnimalsCells
    30. Wi SM, Moon G, Kim J, Kim ST, Shim JH, Chun E, Lee KY. TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-?B. J Biol Chem. 2014 Dec 19; 289(51):35205-14. PMID: 25371197.
      Citations: 42     Fields:    Translation:HumansCells
    31. Mi Wi S, Park J, Shim JH, Chun E, Lee KY. Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-?Bs in Toll-like receptor 4 signaling. Mol Biol Cell. 2015 Jan 01; 26(1):151-60. PMID: 25355951.
      Citations: 14     Fields:    Translation:HumansCells
    32. Kim SY, Baik KH, Baek KH, Chah KH, Kim KA, Moon G, Jung E, Kim ST, Shim JH, Greenblatt MB, Chun E, Lee KY. S6K1 negatively regulates TAK1 activity in the toll-like receptor signaling pathway. Mol Cell Biol. 2014 Feb; 34(3):510-21. PMID: 24277938.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    33. Park KH, Park B, Yoon DS, Kwon SH, Shin DM, Lee JW, Lee HG, Shim JH, Park JH, Lee JM. Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway. Cell Commun Signal. 2013 Oct 02; 11:74. PMID: 24088289.
      Citations: 25     Fields:    Translation:AnimalsCells
    34. Yong Kim S, Jeong S, Chah KH, Jung E, Baek KH, Kim ST, Shim JH, Chun E, Lee KY. Salt-inducible kinases 1 and 3 negatively regulate Toll-like receptor 4-mediated signal. Mol Endocrinol. 2013 Nov; 27(11):1958-68. PMID: 24061540.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    35. Greenblatt MB, Shim JH. Osteoimmunology: a brief introduction. Immune Netw. 2013 Aug; 13(4):111-5. PMID: 24009537.
      Citations:    
    36. Shim JH, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA, Zaller D, Zhai B, Gygi S, Glimcher LH, Jones DC. Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 2013 Sep; 123(9):4010-22. PMID: 23945236.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    37. Greenblatt MB, Shim JH, Glimcher LH. Mitogen-activated protein kinase pathways in osteoblasts. Annu Rev Cell Dev Biol. 2013; 29:63-79. PMID: 23725048.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    38. Park TY, Kim SH, Shin YC, Lee NH, Lee RK, Shim JH, Glimcher LH, Mook-Jung I, Cheong E, Kim WK, Honda F, Morio T, Lim JS, Lee SK. Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin. J Control Release. 2013 Mar 28; 166(3):307-15. PMID: 23298615.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    39. Wein MN, Jones DC, Shim JH, Aliprantis AO, Sulyanto R, Lazarevic V, Poliachik SL, Gross TS, Glimcher LH. Control of bone resorption in mice by Schnurri-3. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):8173-8. PMID: 22573816.
      Citations: 18     Fields:    Translation:AnimalsCells
    40. Shim JH, Greenblatt MB, Singh A, Brady N, Hu D, Drapp R, Ogawa W, Kasuga M, Noda T, Yang SH, Lee SK, Rebel VI, Glimcher LH. Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. J Clin Invest. 2012 Jan; 122(1):91-106. PMID: 22133875.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    41. Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J Clin Invest. 2011 Nov; 121(11):4383-92. PMID: 21965325.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    42. Zou W, Chen X, Shim JH, Huang Z, Brady N, Hu D, Drapp R, Sigrist K, Glimcher LH, Jones D. The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. Nat Cell Biol. 2011 Jan; 13(1):59-65. PMID: 21170031.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    43. Lazarevic V, Chen X, Shim JH, Hwang ES, Jang E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH. T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding ROR?t. Nat Immunol. 2011 Jan; 12(1):96-104. PMID: 21151104.
      Citations: 196     Fields:    Translation:AnimalsCells
    44. Shin MJ, Shim JH, Lee JY, Chae WJ, Lee HK, Morio T, Park JH, Chang EJ, Lee SK. Qualitative and quantitative differences in the intensity of Fas-mediated intracellular signals determine life and death in T cells. Int J Hematol. 2010 Sep; 92(2):262-70. PMID: 20658220.
      Citations: 1     Fields:    Translation:HumansCells
    45. Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest. 2010 Jul; 120(7):2457-73. PMID: 20551513.
      Citations: 181     Fields:    Translation:HumansAnimalsCells
    46. Greenblatt MB, Shim JH, Glimcher LH. TAK1 mediates BMP signaling in cartilage. Ann N Y Acad Sci. 2010 Mar; 1192:385-90. PMID: 20392264.
      Citations: 19     Fields:    Translation:AnimalsCells
    47. Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH. TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J. 2009 Jul 22; 28(14):2028-41. PMID: 19536134.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    48. Kim SY, Jo HY, Kim MH, Cha YY, Choi SW, Shim JH, Kim TJ, Lee KY. H2O2-dependent hyperoxidation of peroxiredoxin 6 (Prdx6) plays a role in cellular toxicity via up-regulation of iPLA2 activity. J Biol Chem. 2008 Nov 28; 283(48):33563-8. PMID: 18826942.
      Citations: 46     Fields:    Translation:HumansCells
    49. Mendoza H, Campbell DG, Burness K, Hastie J, Ronkina N, Shim JH, Arthur JS, Davis RJ, Gaestel M, Johnson GL, Ghosh S, Cohen P. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J. 2008 Feb 01; 409(3):711-22. PMID: 18021073.
      Citations: 30     Fields:    Translation:AnimalsCells
    50. Shim JH, Xiao C, Hayden MS, Lee KY, Trombetta ES, Pypaert M, Nara A, Yoshimori T, Wilm B, Erdjument-Bromage H, Tempst P, Hogan BL, Mellman I, Ghosh S. CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol. 2006 Mar 27; 172(7):1045-56. PMID: 16567502.
      Citations: 49     Fields:    Translation:AnimalsCells
    51. Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, Lee KY, Bussey C, Steckel M, Tanaka N, Yamada G, Akira S, Matsumoto K, Ghosh S. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 2005 Nov 15; 19(22):2668-81. PMID: 16260493.
      Citations: 342     Fields:    Translation:HumansAnimalsCells
    52. Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S. PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science. 2005 Apr 01; 308(5718):114-8. PMID: 15802604.
      Citations: 106     Fields:    Translation:HumansCells
    53. May MJ, Larsen SE, Shim JH, Madge LA, Ghosh S. A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase. J Biol Chem. 2004 Oct 29; 279(44):45528-39. PMID: 15319427.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    54. Xiao C, Shim JH, Kl├╝ppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S. Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 2003 Dec 01; 17(23):2933-49. PMID: 14633973.
      Citations: 28     Fields:    Translation:AnimalsCells
    55. Shim JH, Lee HK, Chang EJ, Chae WJ, Han JH, Han DJ, Morio T, Yang JJ, Bothwell A, Lee SK. Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10617-22. PMID: 12149481.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    Shim's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (354)
    Explore
    _
    Co-Authors (6)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _