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Sylvain Cecchini PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentGene Therapy Center

    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    Collapse Biography 
    Collapse education and training
    University of Sherbrooke, Sherbrooke, QC, CanadaPHDRadiology/Nuclear Medicine

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Destro F, Joseph J, Srinivasan P, Kanter JM, Neufeld C, Wolfrum JM, Barone PW, Springs SL, Sinskey AJ, Cecchini S, Kotin RM, Braatz RD. Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system. Mol Ther Methods Clin Dev. 2023 Sep 14; 30:122-146. PMID: 37746245.
    2. Smith RH, Hallwirth CV, Westerman M, Hetherington NA, Tseng YS, Cecchini S, Virag T, Ziegler ML, Rogozin IB, Koonin EV, Agbandje-McKenna M, Kotin RM, Alexander IE. Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus. Sci Rep. 2016 07 05; 6:28965. PMID: 27377618.
      Citations: 18     Fields:    Translation:AnimalsCells
    3. Bish LT, Sleeper MM, Forbes SC, Wang B, Reynolds C, Singletary GE, Trafny D, Morine KJ, Sanmiguel J, Cecchini S, Virag T, Vulin A, Beley C, Bogan J, Wilson JM, Vandenborne K, Kornegay JN, Walter GA, Kotin RM, Garcia L, Sweeney HL. Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping. Mol Ther. 2012 Mar; 20(3):580-9. PMID: 22146342.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    4. Cecchini S, Virag T, Kotin RM. Reproducible high yields of recombinant adeno-associated virus produced using invertebrate cells in 0.02- to 200-liter cultures. Hum Gene Ther. 2011 Aug; 22(8):1021-30. PMID: 21381980.
      Citations: 35     Fields:    Translation:AnimalsCells
    5. Heroux J, Gharib AM, Danthi NS, Cecchini S, Ohayon J, Pettigrew RI. High-affinity alphavbeta3 integrin targeted optical probe as a new imaging biomarker for early atherosclerosis: initial studies in Watanabe rabbits. Mol Imaging Biol. 2010 Jan-Feb; 12(1):2-8. PMID: 19898904.
      Citations: 8     Fields:    Translation:Animals
    6. Virag T, Cecchini S, Kotin RM. Producing recombinant adeno-associated virus in foster cells: overcoming production limitations using a baculovirus-insect cell expression strategy. Hum Gene Ther. 2009 Aug; 20(8):807-17. PMID: 19604040.
      Citations: 35     Fields:    Translation:AnimalsCells
    7. Dextraze ME, Cecchini S, Bergeron F, Girouard S, Turcotte K, Wagner JR, Hunting DJ. Reaching for the other side: generating sequence-dependent interstrand cross-links with 5-bromodeoxyuridine and gamma-rays. Biochemistry. 2009 Mar 10; 48(9):2005-11. PMID: 19216505.
      Citations: 6     Fields:    Translation:Cells
    8. Cecchini S, Negrete A, Virag T, Graham BS, Cohen JI, Kotin RM. Evidence of prior exposure to human bocavirus as determined by a retrospective serological study of 404 serum samples from adults in the United States. Clin Vaccine Immunol. 2009 May; 16(5):597-604. PMID: 19244471.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    9. Cecchini S, Masson C, La Madeleine C, Huels MA, Sanche L, Wagner JR, Hunting DJ. Interstrand cross-link induction by UV radiation in bromodeoxyuridine-substituted DNA: dependence on DNA conformation. Biochemistry. 2005 Dec 27; 44(51):16957-66. PMID: 16363809.
      Citations: 12     Fields:    Translation:Cells
    10. Gantchev TG, Cecchini S, Hunting DJ. Dynamic conformational states of DNA containing T.T or BrdU.T mispaired bases: wobble H-bond pairing versus cross-strand inter-atomic contacts. J Mol Model. 2005 Mar; 11(2):141-59. PMID: 15719239.
      Citations: 5     Fields:    Translation:Cells
    11. Cecchini S, Girouard S, Huels MA, Sanche L, Hunting DJ. Interstrand cross-links: a new type of gamma-ray damage in bromodeoxyuridine-substituted DNA. Biochemistry. 2005 Feb 15; 44(6):1932-40. PMID: 15697218.
      Citations: 18     Fields:    Translation:Cells
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