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Michael Anthony Lodato PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUniversity of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMolecular, Cell and Cancer Biology


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    Collapse Biography 
    Collapse education and training
    Hofstra University, Hempstead, NY, United StatesBSBiology
    Massachusetts Institute of Technology, Cambridge, MA, United StatesPHDMolecular Biology
    Collapse awards and honors
    2018Kreig Cortical Explorer, Cajal Club
    2020Child Health Award, Charles H. Hood Foundation
    2020Early Career Award, Glenn Foundation for Medical Research and the American Federation for Aging Research
    2019Next Generation Leaders Council Appointment, Allen Institute for Brain Science

    Collapse Overview 
    Collapse overview

    Our laboratory focuses on the rates, causes, and consequences of somatic mutations in the human brain. The genome is under relentless attack by environmental and endogenous mutagens. This onslaught sometimes results in somatic mutation, which results in neighboring cells in an organ like the human brain having distinct genotypes, and raises the possibility that genetic information is lost in cells of the body as we age. Indeed, our work has shown that somatic mutations accumulate in post-mitotic human neurons during aging, sometimes affecting genes critical for neuronal function.

    Somatic mutations are ultra-rare and cannot be studied using standard genomic analysis. Work in our lab involves applying cutting-edge single-cell genomic techniques pioneered by us and other groups to new questions in the field of somatic mutation, as well as innovating new technologies to allow us and the rest of the field to continue to study this process.

    For more information about our lab, please visit our lab website.



    Collapse Rotation Projects

    Rotations will revolve around studying somatic mutations in the normal brain, in the diseased brain, and outside of the brain using single-cell genomics. Please contact Dr. Lodato for details.



    Collapse Post Docs

    Wet-lab and Bioinformatic postdoctoral fellow positions are available for candidates with recent Ph.D. or M.D./Ph.D. degrees in Molecular Biology, Neuroscience, Genetics, Genomics, Cell Biology, or related fields. They should be highly motivated, have a strong desire to learn, and excellent communication skills. Applicants should send their CV, summary of previous research and the name of three references to Dr. Michael Lodato.




    Collapse Research 
    Collapse research activities and funding
    R00AG054748     (LODATO, MICHAEL ANTHONY)Jul 1, 2017 - Aug 31, 2022
    NIH
    SINGLE-CELL ANALYSIS OF SOMATIC MUTATION IN AGING ANO NEUROOEGENERATIVE DISEASE IN THE HUMAN BRAIN
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kim J, Zhao B, Huang AY, Miller MB, Lodato MA, Walsh CA, Lee EA. APP gene copy number changes reflect exogenous contamination. Nature. 2020 Aug; 584(7821):E20-E28. PMID: 32814883.
      View in: PubMed
    2. Lodato MA, Walsh CA. Corrigendum: Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms. Hum Mol Genet. 2020 Feb 01; 29(3):527. PMID: 31778186.
      View in: PubMed
    3. Lodato MA, Walsh CA. Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms. Hum Mol Genet. 2019 10 15; 28(R2):R197-R206. PMID: 31578549.
      View in: PubMed
    4. Bohrson CL, Barton AR, Lodato MA, Rodin RE, Luquette LJ, Viswanadham VV, Gulhan DC, Cort├ęs-Ciriano I, Sherman MA, Kwon M, Coulter ME, Galor A, Walsh CA, Park PJ. Linked-read analysis identifies mutations in single-cell DNA-sequencing data. Nat Genet. 2019 04; 51(4):749-754. PMID: 30886424.
      View in: PubMed
    5. Sherman MA, Barton AR, Lodato MA, Vitzthum C, Coulter ME, Walsh CA, Park PJ. PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation. Nucleic Acids Res. 2018 02 28; 46(4):e20. PMID: 29186545.
      View in: PubMed
    6. Lodato MA, Rodin RE, Bohrson CL, Coulter ME, Barton AR, Kwon M, Sherman MA, Vitzthum CM, Luquette LJ, Yandava CN, Yang P, Chittenden TW, Hatem NE, Ryu SC, Woodworth MB, Park PJ, Walsh CA. Aging and neurodegeneration are associated with increased mutations in single human neurons. Science. 2018 02 02; 359(6375):555-559. PMID: 29217584.
      View in: PubMed
    7. McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM. Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science. 2017 Apr 28; 356(6336). PMID: 28450582.
      View in: PubMed
    8. Lodato MA, Woodworth MB, Lee S, Evrony GD, Mehta BK, Karger A, Lee S, Chittenden TW, D'Gama AM, Cai X, Luquette LJ, Lee E, Park PJ, Walsh CA. Somatic mutation in single human neurons tracks developmental and transcriptional history. Science. 2015 Oct 02; 350(6256):94-98. PMID: 26430121.
      View in: PubMed
    9. Kim J, Su SC, Wang H, Cheng AW, Cassady JP, Lodato MA, Lengner CJ, Chung CY, Dawlaty MM, Tsai LH, Jaenisch R. Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell. 2011 Nov 04; 9(5):413-9. PMID: 22019014.
      View in: PubMed
    10. Creyghton MP, Markoulaki S, Levine SS, Hanna J, Lodato MA, Sha K, Young RA, Jaenisch R, Boyer LA. H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell. 2008 Nov 14; 135(4):649-61. PMID: 18992931.
      View in: PubMed
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