Header Logo

Michael Anthony Lodato PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUniversity of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences

    Collapse Biography 
    Collapse education and training
    Hofstra University, Hempstead, NY, United StatesBSBiology
    Massachusetts Institute of Technology, Cambridge, MA, United StatesPHDMolecular Biology
    Collapse awards and honors
    2018Kreig Cortical Explorer, Cajal Club
    2020Child Health Award, Charles H. Hood Foundation
    2020Early Career Award, Glenn Foundation for Medical Research and the American Federation for Aging Research
    2019Next Generation Leaders Council Appointment, Allen Institute for Brain Science

    Collapse Overview 
    Collapse overview

    Our laboratory focuses on the rates, causes, and consequences of somatic mutations in the human brain. The genome is under relentless attack by environmental and endogenous mutagens. This onslaught sometimes results in somatic mutation, which results in neighboring cells in an organ like the human brain having distinct genotypes, and raises the possibility that genetic information is lost in cells of the body as we age. Indeed, our work has shown that somatic mutations accumulate in post-mitotic human neurons during aging, sometimes affecting genes critical for neuronal function.

    Somatic mutations are ultra-rare and cannot be studied using standard genomic analysis. Work in our lab involves applying cutting-edge single-cell genomic techniques pioneered by us and other groups to new questions in the field of somatic mutation, as well as innovating new technologies to allow us and the rest of the field to continue to study this process.

    For more information about our lab, please visit our lab website.

    Collapse Rotation Projects

    Rotations will revolve around studying somatic mutations in the normal brain, in the diseased brain, and outside of the brain using single-cell genomics. Please contact Dr. Lodato for details.

    Collapse Post Docs

    Wet-lab and Bioinformatic postdoctoral fellow positions are available for candidates with recent Ph.D. or M.D./Ph.D. degrees in Molecular Biology, Neuroscience, Genetics, Genomics, Cell Biology, or related fields. They should be highly motivated, have a strong desire to learn, and excellent communication skills. Applicants should send their CV, summary of previous research and the name of three references to Dr. Michael Lodato.

    Collapse webpage

    Collapse Research 
    Collapse research activities and funding
    R00AG054748     (LODATO, MICHAEL ANTHONY)Jul 1, 2017 - Aug 31, 2022
    Role: Principal Investigator

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lai J, Demirbas D, Kim J, Jeffries AM, Tolles A, Park J, Chittenden TW, Buckley PG, Yu TW, Lodato MA, Lee EA. ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia. Cell Rep. 2024 01 23; 43(1):113622. PMID: 38159274.
      Citations: 1     Fields:    Translation:HumansCells
    2. Kim SN, Viswanadham VV, Doan RN, Dou Y, Bizzotto S, Khoshkhoo S, Huang AY, Yeh R, Chhouk B, Truong A, Chappell KM, Beaudin M, Barton A, Akula SK, Rento L, Lodato M, Ganz J, Szeto RA, Li P, Tsai JW, Hill RS, Park PJ, Walsh CA. Cell lineage analysis with somatic mutations reveals late divergence of neuronal cell types and cortical areas in human cerebral cortex. bioRxiv. 2023 Nov 06. PMID: 37986891.
    3. Lodato MA, Vijg J. Editorial: Somatic mutations, genome mosaicism and aging. Front Aging. 2022; 3:1115408. PMID: 36698749.
    4. Kim J, Huang AY, Johnson SL, Lai J, Isacco L, Jeffries AM, Miller MB, Lodato MA, Walsh CA, Lee EA. Prevalence and mechanisms of somatic deletions in single human neurons during normal aging and in DNA repair disorders. Nat Commun. 2022 10 07; 13(1):5918. PMID: 36207339.
      Citations: 5     Fields:    Translation:HumansCells
    5. Luquette LJ, Miller MB, Zhou Z, Bohrson CL, Zhao Y, Jin H, Gulhan D, Ganz J, Bizzotto S, Kirkham S, Hochepied T, Libert C, Galor A, Kim J, Lodato MA, Garaycoechea JI, Gawad C, West J, Walsh CA, Park PJ. Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements. Nat Genet. 2022 10; 54(10):1564-1571. PMID: 36163278.
      Citations: 14     Fields:    Translation:HumansCells
    6. Choudhury S, Huang AY, Kim J, Zhou Z, Morillo K, Maury EA, Tsai JW, Miller MB, Lodato MA, Araten S, Hilal N, Lee EA, Chen MH, Walsh CA. Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity. Nat Aging. 2022 08; 2(8):714-725. PMID: 36051457.
    7. Miller MB, Huang AY, Kim J, Zhou Z, Kirkham SL, Maury EA, Ziegenfuss JS, Reed HC, Neil JE, Rento L, Ryu SC, Ma CC, Luquette LJ, Ames HM, Oakley DH, Frosch MP, Hyman BT, Lodato MA, Lee EA, Walsh CA. Somatic genomic changes in single Alzheimer's disease neurons. Nature. 2022 04; 604(7907):714-722. PMID: 35444284.
      Citations: 42     Fields:    Translation:HumansCells
    8. Bourseguin J, Cheng W, Talbot E, Hardy L, Lai J, Jeffries AM, Lodato MA, Lee EA, Khoronenkova SV. Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction. Nucleic Acids Res. 2022 03 21; 50(5):2700-2718. PMID: 35212385.
      Citations: 9     Fields:    Translation:HumansCells
    9. Kim J, Zhao B, Huang AY, Miller MB, Lodato MA, Walsh CA, Lee EA. APP gene copy number changes reflect exogenous contamination. Nature. 2020 08; 584(7821):E20-E28. PMID: 32814883.
      Citations: 9     Fields:    
    10. Lodato MA, Walsh CA. Corrigendum: Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms. Hum Mol Genet. 2020 Feb 01; 29(3):527. PMID: 31778186.
      Citations:    Fields:    
    11. Lodato MA, Walsh CA. Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms. Hum Mol Genet. 2019 10 15; 28(R2):R197-R206. PMID: 31578549.
      Citations: 25     Fields:    Translation:HumansCells
    12. Bohrson CL, Barton AR, Lodato MA, Rodin RE, Luquette LJ, Viswanadham VV, Gulhan DC, Cort?s-Ciriano I, Sherman MA, Kwon M, Coulter ME, Galor A, Walsh CA, Park PJ. Linked-read analysis identifies mutations in single-cell DNA-sequencing data. Nat Genet. 2019 04; 51(4):749-754. PMID: 30886424.
      Citations: 47     Fields:    Translation:Humans
    13. Sherman MA, Barton AR, Lodato MA, Vitzthum C, Coulter ME, Walsh CA, Park PJ. PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation. Nucleic Acids Res. 2018 02 28; 46(4):e20. PMID: 29186545.
      Citations: 10     Fields:    Translation:Humans
    14. Lodato MA, Rodin RE, Bohrson CL, Coulter ME, Barton AR, Kwon M, Sherman MA, Vitzthum CM, Luquette LJ, Yandava CN, Yang P, Chittenden TW, Hatem NE, Ryu SC, Woodworth MB, Park PJ, Walsh CA. Aging and neurodegeneration are associated with increased mutations in single human neurons. Science. 2018 02 02; 359(6375):555-559. PMID: 29217584.
      Citations: 251     Fields:    Translation:HumansCells
    15. McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM. Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science. 2017 04 28; 356(6336). PMID: 28450582.
      Citations: 111     Fields:    Translation:HumansCells
    16. Lodato MA, Woodworth MB, Lee S, Evrony GD, Mehta BK, Karger A, Lee S, Chittenden TW, D'Gama AM, Cai X, Luquette LJ, Lee E, Park PJ, Walsh CA. Somatic mutation in single human neurons tracks developmental and transcriptional history. Science. 2015 Oct 02; 350(6256):94-98. PMID: 26430121.
      Citations: 269     Fields:    Translation:HumansCells
    17. Kim J, Su SC, Wang H, Cheng AW, Cassady JP, Lodato MA, Lengner CJ, Chung CY, Dawlaty MM, Tsai LH, Jaenisch R. Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell. 2011 Nov 04; 9(5):413-9. PMID: 22019014.
      Citations: 123     Fields:    Translation:AnimalsCells
    18. Creyghton MP, Markoulaki S, Levine SS, Hanna J, Lodato MA, Sha K, Young RA, Jaenisch R, Boyer LA. H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell. 2008 Nov 14; 135(4):649-61. PMID: 18992931.
      Citations: 180     Fields:    Translation:AnimalsCells
    Lodato's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (87)
    Similar People (60)
    Same Department Expand Description
    Physical Neighbors