Michael Anthony Lodato PhD
Title | Assistant Professor |
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Institution | UMass Chan Medical School |
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Department | Molecular, Cell and Cancer Biology |
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Address | University of Massachusetts Medical School 55 Lake Ave North Worcester MA 01605
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Institution | T.H. Chan School of Medicine |
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Department | Molecular, Cell and Cancer Biology |
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Institution | Morningside Graduate School of Biomedical Sciences |
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Department | Interdisciplinary Graduate Program |
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Institution | Morningside Graduate School of Biomedical Sciences |
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Department | Neuroscience |
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Biography
Hofstra University, Hempstead, NY, United States | BS | | Biology |
Massachusetts Institute of Technology, Cambridge, MA, United States | PHD | | Molecular Biology |
2018 | Kreig Cortical Explorer, Cajal Club |
2020 | Child Health Award, Charles H. Hood Foundation |
2020 | Early Career Award, Glenn Foundation for Medical Research and the American Federation for Aging Research |
2019 | Next Generation Leaders Council Appointment, Allen Institute for Brain Science |
Overview
Our laboratory focuses on the rates, causes, and consequences of somatic mutations in the human brain. The genome is under relentless attack by environmental and endogenous mutagens. This onslaught sometimes results in somatic mutation, which results in neighboring cells in an organ like the human brain having distinct genotypes, and raises the possibility that genetic information is lost in cells of the body as we age. Indeed, our work has shown that somatic mutations accumulate in post-mitotic human neurons during aging, sometimes affecting genes critical for neuronal function.
Somatic mutations are ultra-rare and cannot be studied using standard genomic analysis. Work in our lab involves applying cutting-edge single-cell genomic techniques pioneered by us and other groups to new questions in the field of somatic mutation, as well as innovating new technologies to allow us and the rest of the field to continue to study this process.
For more information about our lab, please visit our lab website.
Rotations will revolve around studying somatic mutations in the normal brain, in the diseased brain, and outside of the brain using single-cell genomics. Please contact Dr. Lodato for details.
Wet-lab and Bioinformatic postdoctoral fellow positions are available for candidates with recent Ph.D. or M.D./Ph.D. degrees in Molecular Biology, Neuroscience, Genetics, Genomics, Cell Biology, or related fields. They should be highly motivated, have a strong desire to learn, and excellent communication skills. Applicants should send their CV, summary of previous research and the name of three references to Dr. Michael Lodato.
Research
R00AG054748 (LODATO, MICHAEL ANTHONY)Jul 1, 2017 - Aug 31, 2022 NIH SINGLE-CELL ANALYSIS OF SOMATIC MUTATION IN AGING ANO NEUROOEGENERATIVE DISEASE IN THE HUMAN BRAIN Role: Principal Investigator |
Featured Content
Bibliographic
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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Lai J, Demirbas D, Kim J, Jeffries AM, Tolles A, Park J, Chittenden TW, Buckley PG, Yu TW, Lodato MA, Lee EA. ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia. Cell Rep. 2024 01 23; 43(1):113622.
PMID: 38159274.
Citations:
1 Fields:
Translation:
HumansCells
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Kim SN, Viswanadham VV, Doan RN, Dou Y, Bizzotto S, Khoshkhoo S, Huang AY, Yeh R, Chhouk B, Truong A, Chappell KM, Beaudin M, Barton A, Akula SK, Rento L, Lodato M, Ganz J, Szeto RA, Li P, Tsai JW, Hill RS, Park PJ, Walsh CA. Cell lineage analysis with somatic mutations reveals late divergence of neuronal cell types and cortical areas in human cerebral cortex. bioRxiv. 2023 Nov 06.
PMID: 37986891.
Citations:
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Lodato MA, Vijg J. Editorial: Somatic mutations, genome mosaicism and aging. Front Aging. 2022; 3:1115408.
PMID: 36698749.
Citations:
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Kim J, Huang AY, Johnson SL, Lai J, Isacco L, Jeffries AM, Miller MB, Lodato MA, Walsh CA, Lee EA. Prevalence and mechanisms of somatic deletions in single human neurons during normal aging and in DNA repair disorders. Nat Commun. 2022 10 07; 13(1):5918.
PMID: 36207339.
Citations:
5 Fields:
Translation:
HumansCells
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Luquette LJ, Miller MB, Zhou Z, Bohrson CL, Zhao Y, Jin H, Gulhan D, Ganz J, Bizzotto S, Kirkham S, Hochepied T, Libert C, Galor A, Kim J, Lodato MA, Garaycoechea JI, Gawad C, West J, Walsh CA, Park PJ. Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements. Nat Genet. 2022 10; 54(10):1564-1571.
PMID: 36163278.
Citations:
14 Fields:
Translation:
HumansCells
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Choudhury S, Huang AY, Kim J, Zhou Z, Morillo K, Maury EA, Tsai JW, Miller MB, Lodato MA, Araten S, Hilal N, Lee EA, Chen MH, Walsh CA. Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity. Nat Aging. 2022 08; 2(8):714-725.
PMID: 36051457.
Citations:
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Miller MB, Huang AY, Kim J, Zhou Z, Kirkham SL, Maury EA, Ziegenfuss JS, Reed HC, Neil JE, Rento L, Ryu SC, Ma CC, Luquette LJ, Ames HM, Oakley DH, Frosch MP, Hyman BT, Lodato MA, Lee EA, Walsh CA. Somatic genomic changes in single Alzheimer's disease neurons. Nature. 2022 04; 604(7907):714-722.
PMID: 35444284.
Citations:
42 Fields:
Translation:
HumansCells
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Bourseguin J, Cheng W, Talbot E, Hardy L, Lai J, Jeffries AM, Lodato MA, Lee EA, Khoronenkova SV. Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction. Nucleic Acids Res. 2022 03 21; 50(5):2700-2718.
PMID: 35212385.
Citations:
9 Fields:
Translation:
HumansCells
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Kim J, Zhao B, Huang AY, Miller MB, Lodato MA, Walsh CA, Lee EA. APP gene copy number changes reflect exogenous contamination. Nature. 2020 08; 584(7821):E20-E28.
PMID: 32814883.
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Lodato MA, Walsh CA. Corrigendum: Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms. Hum Mol Genet. 2020 Feb 01; 29(3):527.
PMID: 31778186.
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Lodato MA, Walsh CA. Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms. Hum Mol Genet. 2019 10 15; 28(R2):R197-R206.
PMID: 31578549.
Citations:
25 Fields:
Translation:
HumansCells
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Bohrson CL, Barton AR, Lodato MA, Rodin RE, Luquette LJ, Viswanadham VV, Gulhan DC, Cort?s-Ciriano I, Sherman MA, Kwon M, Coulter ME, Galor A, Walsh CA, Park PJ. Linked-read analysis identifies mutations in single-cell DNA-sequencing data. Nat Genet. 2019 04; 51(4):749-754.
PMID: 30886424.
Citations:
47 Fields:
Translation:
Humans
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Sherman MA, Barton AR, Lodato MA, Vitzthum C, Coulter ME, Walsh CA, Park PJ. PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation. Nucleic Acids Res. 2018 02 28; 46(4):e20.
PMID: 29186545.
Citations:
10 Fields:
Translation:
Humans
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Lodato MA, Rodin RE, Bohrson CL, Coulter ME, Barton AR, Kwon M, Sherman MA, Vitzthum CM, Luquette LJ, Yandava CN, Yang P, Chittenden TW, Hatem NE, Ryu SC, Woodworth MB, Park PJ, Walsh CA. Aging and neurodegeneration are associated with increased mutations in single human neurons. Science. 2018 02 02; 359(6375):555-559.
PMID: 29217584.
Citations:
251 Fields:
Translation:
HumansCells
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McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM. Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science. 2017 04 28; 356(6336).
PMID: 28450582.
Citations:
111 Fields:
Translation:
HumansCells
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Lodato MA, Woodworth MB, Lee S, Evrony GD, Mehta BK, Karger A, Lee S, Chittenden TW, D'Gama AM, Cai X, Luquette LJ, Lee E, Park PJ, Walsh CA. Somatic mutation in single human neurons tracks developmental and transcriptional history. Science. 2015 Oct 02; 350(6256):94-98.
PMID: 26430121.
Citations:
269 Fields:
Translation:
HumansCells
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Kim J, Su SC, Wang H, Cheng AW, Cassady JP, Lodato MA, Lengner CJ, Chung CY, Dawlaty MM, Tsai LH, Jaenisch R. Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell. 2011 Nov 04; 9(5):413-9.
PMID: 22019014.
Citations:
123 Fields:
Translation:
AnimalsCells
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Creyghton MP, Markoulaki S, Levine SS, Hanna J, Lodato MA, Sha K, Young RA, Jaenisch R, Boyer LA. H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell. 2008 Nov 14; 135(4):649-61.
PMID: 18992931.
Citations:
180 Fields:
Translation:
AnimalsCells
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Year | Publications |
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2008 | 1 |
2011 | 1 |
2015 | 1 |
2017 | 2 |
2018 | 1 |
2019 | 2 |
2020 | 2 |
2022 | 5 |
2023 | 3 |
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Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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