Astrocytes

"Astrocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.

Descriptor ID	D001253
MeSH Number(s)	A08.637.200 A11.650.200
Concept/Terms	Astrocytes Astrocytes Astrocyte Astroglia Astroglias

Below are MeSH descriptors whose meaning is more general than "Astrocytes".

Anatomy [A]
Nervous System [A08]
Neuroglia [A08.637]
Astrocytes [A08.637.200]
Cells [A11]
Neuroglia [A11.650]
Astrocytes [A11.650.200]

Below are MeSH descriptors whose meaning is related to "Astrocytes".

Below are MeSH descriptors whose meaning is more specific than "Astrocytes".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Astrocytes" by people in this website by year, and whether "Astrocytes" was a major or minor topic of these publications.

Bar chart showing 95 publications over 25 distinct years, with a maximum of 9 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	1	2	3
2002	4	0	4
2003	1	3	4
2004	1	0	1
2005	0	3	3
2006	1	3	4
2008	5	1	6
2009	1	0	1
2010	1	0	1
2011	4	2	6
2013	1	1	2
2014	1	4	5
2015	1	3	4
2016	1	2	3
2017	3	0	3
2018	1	6	7
2019	0	1	1
2020	4	3	7
2021	4	5	9
2022	3	4	7
2023	0	1	1
2024	2	2	4
2025	3	2	5
2026	2	1	3

Below are the most recent publications written about "Astrocytes" by people in Profiles.

Faust TE, Saito A, Ishikawa S, Yang K, Xin W, Namkung H, Agarwal A, Ramos A, Lee BJ, Hayes L, Srivastava R, Adelakun S, Saha S, Palen T, Cash-Padgett T, Wood DJ, Carloni E, Yusa R, Jaaro-Peled H, Fahey JW, Bergles DE, Ishizuka K, Sawa A. Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and maladaptive affective behaviors in epilepsy. Sci Adv. 2026 Jul 31; 12(31):eaef6777.

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Sakers K, Sheehan PW, Xin W, Schafer DP, Eroglu C. Glia orchestrate neural circuit development. Dev Cell. 2026 Jul 08; 61(7):1407-1430.

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de Farias IS, Duarte-Barbosa M, Salazar N, Andreata-Santos R, de Lucena VWL, Maricato JT, Gazzinelli RT, Janini LMR, Bortoluci KR. NLRP3 inflammasome activation in astrocytes restricts SARS-CoV-2 through gasdermin-D-driven IL-1? release. Front Immunol. 2025; 16:1703765.

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Sheehan PW, Fass SB, Sapkota D, Kang S, Hollis HC, Lawrence JH, Park S, Sharma A, Schafer DP, Anafi RC, Dougherty JD, Fryer JD, Musiek ES. A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging. Nat Neurosci. 2025 Nov; 28(11):2366-2379.

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Linker KE, Duran-Laforet V, Ollivier M, Yu X, Schafer DP, Khakh BS. Aging in mice alters regionally enriched striatal astrocytes. Nat Commun. 2025 Sep 26; 16(1):8496.

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Faust TE, Lee YH, O'Connor CD, Boyle MA, Gunner G, Dur?n-Laforet V, Ferrari LL, Murphy RE, Badimon A, Sakers K, Eroglu C, Ayata P, Schaefer A, Schafer DP. Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling. Cell. 2025 Sep 18; 188(19):5212-5230.e21.

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Masegosa VM, Fritz E, Corvalan D, Rojas F, Garc?s P, Navarro X, Bloms-Funke P, van Zundert B, Herrando-Grabulosa M. Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned Media. ACS Chem Neurosci. 2025 Aug 06; 16(15):2887-2900.

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Lin JP, Brake A, Donadieu M, Lee A, Smith G, Hu K, Nair G, Kawaguchi R, Sati P, Geschwind DH, Jacobson S, Schafer DP, Reich DS. 4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions. Science. 2025 02 28; 387(6737):eadp6325.

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Petersen N, McCann KE, Stavarache MA, Kim LY, Weinshenker D, Winder DG. Adenosine A2A Receptors Link Astrocytic a1-Adrenergic Signaling to Wake-Promoting Dopamine Neurons. Biol Psychiatry. 2025 May 01; 97(9):915-928.

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Botella Lucena P, Heneka MT. Inflammatory aspects of Alzheimer's disease. Acta Neuropathol. 2024 08 28; 148(1):31.

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