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Brigitte van Zundert PhD

TitleAdjunct Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentNeurology
AddressAvenida Republica 239
Postal 8320000
Santiago
Phone56227703250
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeurology


    Collapse Biography 
    Collapse education and training
    Utrecht University, Utrecht, , NetherlandsMSMolecular Biology
    University of Concepcion, Concepcion, , ChilePHDMolecular and Cell Biology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Jury N, Abarzua S, Diaz I, Guerra MV, Ampuero E, Cubillos P, Martinez P, Herrera-Soto A, Arredondo C, Rojas F, Manterola M, Rojas A, Montecino M, Varela-Nallar L, van Zundert B. Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice. Clin Epigenetics. 2020 Feb 18; 12(1):32. PMID: 32070418.
      View in: PubMed
    2. Calderón-Garcidueñas L, Herrera-Soto A, Jury N, Maher BA, González-Maciel A, Reynoso-Robles R, Ruiz-Rudolph P, van Zundert B, Varela-Nallar L. Reduced repressive epigenetic marks, increased DNA damage and Alzheimer's disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution. Environ Res. 2020 Feb 04; 183:109226. PMID: 32045727.
      View in: PubMed
    3. Abarzúa S, Ampuero E, van Zundert B. Superoxide generation via the NR2B-NMDAR/RasGRF1/NOX2 pathway promotes dendritogenesis. J Cell Physiol. 2019 Dec; 234(12):22985-22995. PMID: 31245854.
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    4. Mardones MD, Jorquera PV, Herrera-Soto A, Ampuero E, Bustos FJ, van Zundert B, Varela-Nallar L. PSD95 regulates morphological development of adult-born granule neurons in the mouse hippocampus. J Chem Neuroanat. 2019 Jul; 98:117-123. PMID: 31047946.
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    5. Rojas A, Sepulveda H, Henriquez B, Aguilar R, Opazo T, Nardocci G, Bustos F, Lian JB, Stein JL, Stein GS, van Zundert B, van Wijnen AJ, Allende ML, Montecino M. Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts. J Cell Physiol. 2018 Sep 07. PMID: 30256410.
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    6. Gonzalez D, Rebolledo DL, Correa LM, Court FA, Cerpa W, Lipson KE, van Zundert B, Brandan E. The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model. Hum Mol Genet. 2018 08 15; 27(16):2913-2926. PMID: 29860398.
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    7. Nuñez-Badinez P, Sepúlveda H, Diaz E, Greffrath W, Treede RD, Stehberg J, Montecino M, van Zundert B. Variable transcriptional responsiveness of the P2X3 receptor gene during CFA-induced inflammatory hyperalgesia. J Cell Biochem. 2018 05; 119(5):3922-3935. PMID: 29219199.
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    8. Matamala JM, Arias-Carrasco R, Sanchez C, Uhrig M, Bargsted L, Matus S, Maracaja-Coutinho V, Abarzua S, van Zundert B, Verdugo R, Manque P, Hetz C. Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis. Neurobiol Aging. 2018 04; 64:123-138. PMID: 29458840.
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    9. Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henríquez B, Guerra MV, Stehberg J, Neve RL, Inestrosa NC, Wyneken U, Fuenzalida M, Härtel S, Sena-Esteves M, Varela-Nallar L, Rots MG, Montecino M, van Zundert B. Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice. Brain. 2017 Dec 01; 140(12):3252-3268. PMID: 29155979.
      View in: PubMed
    10. Lagos-Cabré R, Alvarez A, Kong M, Burgos-Bravo F, Cárdenas A, Rojas-Mancilla E, Pérez-Nuñez R, Herrera-Molina R, Rojas F, Schneider P, Herrera-Marschitz M, Quest AFG, van Zundert B, Leyton L. aVß3 Integrin regulates astrocyte reactivity. J Neuroinflammation. 2017 Sep 29; 14(1):194. PMID: 28962574.
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    11. Gonzalez D, Contreras O, Rebolledo DL, Espinoza JP, van Zundert B, Brandan E. ALS skeletal muscle shows enhanced TGF-ß signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS One. 2017; 12(5):e0177649. PMID: 28520806.
      View in: PubMed
    12. Bustos FJ, Jury N, Martinez P, Ampuero E, Campos M, Abarzúa S, Jaramillo K, Ibing S, Mardones MD, Haensgen H, Kzhyshkowska J, Tevy MF, Neve R, Sanhueza M, Varela-Nallar L, Montecino M, van Zundert B. NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac. J Cell Physiol. 2017 Dec; 232(12):3677-3692. PMID: 28160495.
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    13. Sepulveda H, Aguilar R, Prieto CP, Bustos F, Aedo S, Lattus J, van Zundert B, Palma V, Montecino M. Epigenetic Signatures at the RUNX2-P1 and Sp7 Gene Promoters Control Osteogenic Lineage Commitment of Umbilical Cord-Derived Mesenchymal Stem Cells. J Cell Physiol. 2017 Sep; 232(9):2519-2527. PMID: 27689934.
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    14. Ramírez-Jarquín UN, Rojas F, van Zundert B, Tapia R. Chronic infusion of SOD1G93A astrocyte-secreted factors induces spinal motoneuron degeneration and neuromuscular dysfunction in healthy rats. J Cell Physiol. 2017 Oct; 232(10):2610-2615. PMID: 28128448.
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    15. Ampuero E, Jury N, Härtel S, Marzolo MP, van Zundert B. Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons. J Cell Physiol. 2017 05; 232(5):1187-1199. PMID: 27653801.
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    16. van Zundert B. ALS: new molecular mechanisms and emerging therapeutic targets. Neurosci Lett. 2017 01 01; 636:1-2. PMID: 27746312.
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    17. van Zundert B, Brown RH. Silencing strategies for therapy of SOD1-mediated ALS. Neurosci Lett. 2017 Jan 01; 636:32-39. PMID: 27507699.
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    18. Calderón-Garcidueñas L, Jewells V, Galaz-Montoya C, van Zundert B, Pérez-Calatayud A, Ascencio-Ferrel E, Valencia-Salazar G, Sandoval-Cano M, Carlos E, Solorio E, Acuña-Ayala H, Torres-Jardón R, D'Angiulli A. Interactive and additive influences of Gender, BMI and Apolipoprotein 4 on cognition in children chronically exposed to high concentrations of PM2.5 and ozone. APOE 4 females are at highest risk in Mexico City. Environ Res. 2016 10; 150:411-422. PMID: 27376929.
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    19. Aguilar R, Bustos FJ, Saez M, Rojas A, Allende ML, van Wijnen AJ, van Zundert B, Montecino M. Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus. Biochim Biophys Acta. 2016 08; 1859(8):1043-55. PMID: 27216774.
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    20. Bórquez DA, Urrutia PJ, Wilson C, van Zundert B, Núñez MT, González-Billault C. Dissecting the role of redox signaling in neuronal development. J Neurochem. 2016 05; 137(4):506-17. PMID: 26875993.
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    21. Woehlbier U, Colombo A, Saaranen MJ, Pérez V, Ojeda J, Bustos FJ, Andreu CI, Torres M, Valenzuela V, Medinas DB, Rozas P, Vidal RL, Lopez-Gonzalez R, Salameh J, Fernandez-Collemann S, Muñoz N, Matus S, Armisen R, Sagredo A, Palma K, Irrazabal T, Almeida S, Gonzalez-Perez P, Campero M, Gao FB, Henny P, van Zundert B, Ruddock LW, Concha ML, Henriquez JP, Brown RH, Hetz C. ALS-linked protein disulfide isomerase variants cause motor dysfunction. EMBO J. 2016 Apr 15; 35(8):845-65. PMID: 26869642.
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    22. Rojas A, Aguilar R, Henriquez B, Lian JB, Stein JL, Stein GS, van Wijnen AJ, van Zundert B, Allende ML, Montecino M. Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B. J Biol Chem. 2015 Nov 20; 290(47):28329-42. PMID: 26453309.
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    23. Rojas F, Gonzalez D, Cortes N, Ampuero E, Hernández DE, Fritz E, Abarzua S, Martinez A, Elorza AA, Alvarez A, Court F, van Zundert B. Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling. Front Cell Neurosci. 2015; 9:203. PMID: 26106294.
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    24. Segovia-Miranda F, Serrano F, Dyrda A, Ampuero E, Retamal C, Bravo-Zehnder M, Parodi J, Zamorano P, Valenzuela D, Massardo L, van Zundert B, Inestrosa NC, González A. Pathogenicity of lupus anti-ribosomal P antibodies: role of cross-reacting neuronal surface P antigen in glutamatergic transmission and plasticity in a mouse model. Arthritis Rheumatol. 2015 Jun; 67(6):1598-610. PMID: 25709106.
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    25. Bustos FJ, Varela-Nallar L, Campos M, Henriquez B, Phillips M, Opazo C, Aguayo LG, Montecino M, Constantine-Paton M, Inestrosa NC, van Zundert B. PSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors. PLoS One. 2014; 9(4):e94037. PMID: 24705401.
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    26. Rojas F, Cortes N, Abarzua S, Dyrda A, van Zundert B. Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress. Front Cell Neurosci. 2014; 8:24. PMID: 24570655.
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    27. Henriquez B, Bustos FJ, Aguilar R, Becerra A, Simon F, Montecino M, van Zundert B. Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons. Mol Cell Neurosci. 2013 Nov; 57:130-43. PMID: 23932971.
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    28. Castillo K, Nassif M, Valenzuela V, Rojas F, Matus S, Mercado G, Court FA, van Zundert B, Hetz C. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Autophagy. 2013 Sep; 9(9):1308-20. PMID: 23851366.
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    29. Yoshii A, Zhao JP, Pandian S, van Zundert B, Constantine-Paton M. A Myosin Va mutant mouse with disruptions in glutamate synaptic development and mature plasticity in visual cortex. J Neurosci. 2013 May 08; 33(19):8472-82. PMID: 23658184.
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    30. Wootz H, Fitzsimons-Kantamneni E, Larhammar M, Rotterman TM, Enjin A, Patra K, André E, Van Zundert B, Kullander K, Alvarez FJ. Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model. J Comp Neurol. 2013 May 01; 521(7):1449-69. PMID: 23172249.
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    31. Ugarte GD, Diaz E, Biscaia M, Stehberg J, Montecino M, van Zundert B. Transcription of the pain-related TRPV1 gene requires Runx1 and C/EBPß factors. J Cell Physiol. 2013 Apr; 228(4):860-70. PMID: 23018770.
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    32. Fritz E, Izaurieta P, Weiss A, Mir FR, Rojas P, Gonzalez D, Rojas F, Brown RH, Madrid R, van Zundert B. Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability. J Neurophysiol. 2013 Jun; 109(11):2803-14. PMID: 23486205.
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    33. van Zundert B, Izaurieta P, Fritz E, Alvarez FJ. Early pathogenesis in the adult-onset neurodegenerative disease amyotrophic lateral sclerosis. J Cell Biochem. 2012 Nov; 113(11):3301-12. PMID: 22740507.
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    34. Ugarte GD, Opazo T, Leisewitz F, van Zundert B, Montecino M. Runx1 and C/EBPß transcription factors directly up-regulate P2X3 gene transcription. J Cell Physiol. 2012 Apr; 227(4):1645-52. PMID: 21678417.
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    35. van Zundert B, Zhao JP, Constantine-Paton M. Synaptic drive at developing synapses: transient upregulation of kainate receptors. Dev Neurobiol. 2010 Sep 15; 70(11):737-50. PMID: 20518018.
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    36. Arriagada G, Paredes R, van Wijnen AJ, Lian JB, van Zundert B, Stein GS, Stein JL, Montecino M. 1alpha,25-dihydroxy vitamin D(3) induces nuclear matrix association of the 1alpha,25-dihydroxy vitamin D(3) receptor in osteoblasts independently of its ability to bind DNA. J Cell Physiol. 2010 Feb; 222(2):336-46. PMID: 19885846.
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    37. Sepulveda FJ, Bustos FJ, Inostroza E, Zúñiga FA, Neve RL, Montecino M, van Zundert B. Differential roles of NMDA Receptor Subtypes NR2A and NR2B in dendritic branch development and requirement of RasGRF1. J Neurophysiol. 2010 Apr; 103(4):1758-70. PMID: 20107120.
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    38. van Zundert B, Peuscher MH, Hynynen M, Chen A, Neve RL, Brown RH, Constantine-Paton M, Bellingham MC. Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis. J Neurosci. 2008 Oct 22; 28(43):10864-74. PMID: 18945894.
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    39. Montecinos V, Guzmán P, Barra V, Villagrán M, Muñoz-Montesino C, Sotomayor K, Escobar E, Godoy A, Mardones L, Sotomayor P, Guzmán C, Vásquez O, Gallardo V, van Zundert B, Bono MR, Oñate SA, Bustamante M, Cárcamo JG, Rivas CI, Vera JC. Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione. J Biol Chem. 2007 May 25; 282(21):15506-15. PMID: 17403685.
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    40. van Zundert B, Castro P, Aguayo LG. Glycinergic and GABAergic synaptic transmission are differentially affected by gephyrin in spinal neurons. Brain Res. 2005 Jul 19; 1050(1-2):40-7. PMID: 15963957.
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    41. Aguayo LG, van Zundert B, Tapia JC, Carrasco MA, Alvarez FJ. Changes on the properties of glycine receptors during neuronal development. Brain Res Brain Res Rev. 2004 Dec; 47(1-3):33-45. PMID: 15572161.
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    42. van Zundert B, Yoshii A, Constantine-Paton M. Receptor compartmentalization and trafficking at glutamate synapses: a developmental proposal. Trends Neurosci. 2004 Jul; 27(7):428-37. PMID: 15219743.
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    43. van Zundert B, Alvarez FJ, Tapia JC, Yeh HH, Diaz E, Aguayo LG. Developmental-dependent action of microtubule depolymerization on the function and structure of synaptic glycine receptor clusters in spinal neurons. J Neurophysiol. 2004 Feb; 91(2):1036-49. PMID: 12968009.
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    44. van Zundert B, Alvarez FJ, Yevenes GE, Cárcamo JG, Vera JC, Aguayo LG. Glycine receptors involved in synaptic transmission are selectively regulated by the cytoskeleton in mouse spinal neurons. J Neurophysiol. 2002 Jan; 87(1):640-4. PMID: 11784780.
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