Loading...
Header Logo
Keywords
Last Name
Institution

Edward Kelly MD

TitleAssociate Professor
InstitutionUMMS - Baystate Regional Campus
DepartmentSurgery at UMMS-Baystate
AddressBaystate Health Regional Campus
759 Chestnut Street
Springfield MA 01199
Phone413-794-4022
vCardDownload vCard

    Collapse Biography 
    Collapse education and training
    University of Scranton, Scranton, PA, United StatesBSBiology
    University of Pittsburgh, Pittsburgh, PA, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Arian CM, Imaoka T, Yang J, Kelly EJ, Thummel KE. Gutsy science: In vitro systems of the human intestine to model oral drug disposition. Pharmacol Ther. 2021 Aug 31; 107962. PMID: 34478775.
      View in: PubMed
    2. Van Ness KP, Cesar F, Yeung CK, Himmelfarb J, Kelly EJ. Microphysiological Systems in ADME Sciences. Clin Transl Sci. 2021 Aug 11. PMID: 34378335.
      View in: PubMed
    3. Lidberg KA, Annalora AJ, Jozic M, Elson DJ, Wang L, Bammler TK, Ramm S, Monteiro MB, Himmelfarb J, Marcus CB, Iversen PL, Kelly EJ. Author Correction: Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Sci Rep. 2021 May 17; 11(1):10711. PMID: 34002000.
      View in: PubMed
    4. Lidberg KA, Annalora AJ, Jozic M, Elson DJ, Wang L, Bammler TK, Ramm S, Monteiro MB, Himmelfarb J, Marcus CB, Iversen PL, Kelly EJ. Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Sci Rep. 2021 Feb 25; 11(1):4722. PMID: 33633318.
      View in: PubMed
    5. Nieskens TTG, Persson M, Kelly EJ, Sjögren AK. A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization-Dependent Cisplatin Toxicity. Drug Metab Dispos. 2020 12; 48(12):1303-1311. PMID: 33020068.
      View in: PubMed
    6. Basit A, Neradugomma NK, Wolford C, Fan PW, Murray B, Takahashi RH, Khojasteh SC, Smith BJ, Heyward S, Totah RA, Kelly EJ, Prasad B. Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human. Mol Pharm. 2020 11 02; 17(11):4114-4124. PMID: 32955894.
      View in: PubMed
    7. Imaoka T, Yang J, Wang L, McDonald MG, Afsharinejad Z, Bammler TK, Van Ness K, Yeung CK, Rettie AE, Himmelfarb J, Kelly EJ. Microphysiological system modeling of ochratoxin A-associated nephrotoxicity. Toxicology. 2020 Nov; 444:152582. PMID: 32905824.
      View in: PubMed
    8. Patel RC, Stalter RM, Thomas KK, Tamraz B, Blue SW, Erikson DW, Kim CJ, Kelly EJ, Nanda K, Kourtis AP, Lingappa JR, Mugo N, Baeten JM, Scarsi KK. A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda. AIDS. 2019 11 01; 33(13):1995-2004. PMID: 31306173.
      View in: PubMed
    9. Sachar M, Kelly EJ, Unadkat JD. Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells. AAPS J. 2019 03 27; 21(3):45. PMID: 30919109.
      View in: PubMed
    10. Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G. Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. Drug Metab Dispos. 2018 11; 46(11):1692-1702. PMID: 30076203.
      View in: PubMed
    11. Chapron BD, Chapron A, Phillips B, Okoli MC, Shen DD, Kelly EJ, Himmelfarb J, Thummel KE. Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system ALTEX. 2018; 35(4):504-515. PMID: 29999169.
      View in: PubMed
    12. Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL. Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. JCI Insight. 2017 11 16; 2(22). PMID: 29202460.
      View in: PubMed
    13. Billington S, Ray AS, Salphati L, Xiao G, Chu X, Humphreys WG, Liao M, Lee CA, Mathias A, Hop CECA, Rowbottom C, Evers R, Lai Y, Kelly EJ, Prasad B, Unadkat JD. Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics. Drug Metab Dispos. 2018 02; 46(2):189-196. PMID: 29138286.
      View in: PubMed
    14. Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ. Microphysiological Systems to Assess Nonclinical Toxicity. Curr Protoc Toxicol. 2017 Aug 04; 73:14.18.1-14.18.28. PMID: 28777442.
      View in: PubMed
    15. Lockhart CM, Smith TB, Yang P, Naidu M, Rettie AE, Nath A, Weleber R, Kelly EJ. Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2. Br J Ophthalmol. 2018 02; 102(2):187-194. PMID: 28698241.
      View in: PubMed
    16. Weber EJ, Himmelfarb J, Kelly EJ. Concise Review: Current and Emerging Biomarkers of Nephrotoxicity. Curr Opin Toxicol. 2017 Jun; 4:16-21. PMID: 29057384.
      View in: PubMed
    17. Prasad B, Johnson K, Billington S, Lee C, Chung GW, Brown CD, Kelly EJ, Himmelfarb J, Unadkat JD. Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics. Drug Metab Dispos. 2016 12; 44(12):1920-1924. PMID: 27621205.
      View in: PubMed
    18. Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ. Development of a microphysiological model of human kidney proximal tubule function. Kidney Int. 2016 09; 90(3):627-37. PMID: 27521113.
      View in: PubMed
    19. Wang L, Collins C, Kelly EJ, Chu X, Ray AS, Salphati L, Xiao G, Lee C, Lai Y, Liao M, Mathias A, Evers R, Humphreys W, Hop CE, Kumer SC, Unadkat JD. Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics. Drug Metab Dispos. 2016 11; 44(11):1752-1758. PMID: 27543206.
      View in: PubMed
    20. Parkinson OT, Teitelbaum AM, Whittington D, Kelly EJ, Rettie AE. Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity. Drug Metab Dispos. 2016 10; 44(10):1598-602. PMID: 27468999.
      View in: PubMed
    21. Farooq M, Kelly EJ, Unadkat JD. CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids. Drug Metab Dispos. 2016 May; 44(5):750-7. PMID: 26965986.
      View in: PubMed
    22. Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS. A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol. 2016 Apr; 27(4):1015-28. PMID: 26260164.
      View in: PubMed
    23. Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q. Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014 Dec 15; 92(4):690-700. PMID: 25450675.
      View in: PubMed
    24. Lockhart CM, Nakano M, Rettie AE, Kelly EJ. Generation and characterization of a murine model of Bietti crystalline dystrophy. Invest Ophthalmol Vis Sci. 2014 Aug 12; 55(9):5572-81. PMID: 25118264.
      View in: PubMed
    25. Lee N, Hebert MF, Prasad B, Easterling TR, Kelly EJ, Unadkat JD, Wang J. Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy. Drug Metab Dispos. 2013 Dec; 41(12):2225-32. PMID: 24101703.
      View in: PubMed
    26. Topletz AR, Le HN, Lee N, Chapman JD, Kelly EJ, Wang J, Isoherranen N. Hepatic Cyp2d and Cyp26a1 mRNAs and activities are increased during mouse pregnancy. Drug Metab Dispos. 2013 Feb; 41(2):312-9. PMID: 23150428.
      View in: PubMed
    27. Ho MT, Kelly EJ, Bodor M, Bui T, Kowdley KV, Ho RJ. Novel cytochrome P450-2D6 promoter sequence variations in hepatitis C positive and negative subjects. Ann Hepatol. 2011 Jul-Sep; 10(3):327-32. PMID: 21677335.
      View in: PubMed
    28. Crouthamel MH, Kelly EJ, Ho RJ. Development and characterization of transgenic mouse models for conditional gene knockout in the blood-brain and blood-CSF barriers. Transgenic Res. 2012 Feb; 21(1):113-30. PMID: 21538071.
      View in: PubMed
    29. Kelly EJ, Nakano M, Rohatgi P, Yarov-Yarovoy V, Rettie AE. Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states. Mol Interv. 2011 Apr; 11(2):124-32. PMID: 21540472.
      View in: PubMed
    30. Eyal S, Easterling TR, Carr D, Umans JG, Miodovnik M, Hankins GD, Clark SM, Risler L, Wang J, Kelly EJ, Shen DD, Hebert MF. Pharmacokinetics of metformin during pregnancy. Drug Metab Dispos. 2010 May; 38(5):833-40. PMID: 20118196.
      View in: PubMed
    31. Nakano M, Kelly EJ, Rettie AE. Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. Drug Metab Dispos. 2009 Nov; 37(11):2119-22. PMID: 19661213.
      View in: PubMed
    32. Salama NN, Kelly EJ, Bui T, Ho RJ. The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice. J Pharm Sci. 2005 Jun; 94(6):1216-25. PMID: 15858856.
      View in: PubMed
    33. Bodor M, Kelly EJ, Ho RJ. Characterization of the human MDR1 gene. AAPS J. 2005 Feb 16; 7(1):E1-5. PMID: 16146331.
      View in: PubMed
    34. McConnachie LA, Bodor M, Phillips B, Kelly EJ, Shen DD, Ho RJ. An RT-PCR-based strategy to estimate full-length CYP2D6 mRNA copy number. Genet Test. 2004; 8(3):313-8. PMID: 15727256.
      View in: PubMed
    Kelly's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description