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Edward Kelly MD

TitleAssociate Professor
InstitutionUMass Chan – Baystate Regional Campus
DepartmentSurgery at UMass Chan - Baystate
AddressBaystate Health Regional Campus
759 Chestnut Street
Springfield MA 01199
Phone413-794-4022
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    Collapse Biography 
    Collapse education and training
    University of Scranton, Scranton, PA, United StatesBSBiology
    University of Pittsburgh, Pittsburgh, PA, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tsang YP, Hao T, Mao Q, Kelly EJ, Unadkat JD. Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells. Pharmaceutics. 2024 Feb 16; 16(2). PMID: 38399338.
      Citations:    
    2. Sun A, Hagenbuch B, Kelly EJ, Wang J. Molecular Mechanisms of Organic Anion Transporting Polypeptide-Mediated Organic Anion Clearance at the Blood-Cerebrospinal Fluid Barrier. Mol Pharmacol. 2023 Dec; 104(6):255-265. PMID: 37652713.
      Citations:    Fields:    Translation:HumansAnimals
    3. Kamine TH, Siu M, Kramer KZ, Alouidor R, Kelly E, Deutsch A, Mader TJ, Visintainer P, Grochowski K, Jabbour N. Feasibility and Acceptance of a Teletrauma Surgery Consult Service to Rural and Community Hospitals: A Pilot Study. J Am Coll Surg. 2023 01 01; 236(1):145-153. PMID: 36226848.
      Citations:    Fields:    Translation:Humans
    4. Siu M, Levin D, Christiansen R, Kelly E, Alouidor R, Kamine TH. Prophylactic Splenectomy and Hyposplenism in Spaceflight. Aerosp Med Hum Perform. 2022 Dec 01; 93(12):877-881. PMID: 36757247.
      Citations:    Fields:    Translation:Humans
    5. Levin DR, Siu M, Kramer K, Kelly E, Alouidor R, Fernandez G, Kamine T. Time Cost of Provider Skill: A Pilot Study of Medical Officer Occupied Time By Knowledge, Skill, and Ability Level. Aerosp Med Hum Perform. 2022 Nov 01; 93(11):816-821. PMID: 36309789.
      Citations:    Fields:    Translation:Humans
    6. Kamine TH, Siu M, Kramer K, Kelly E, Alouidor R, Fernandez G, Levin D. Spatial Volume Necessary to Perform Open Appendectomy in a Spacecraft. Aerosp Med Hum Perform. 2022 Oct 01; 93(10):760-763. PMID: 36243909.
      Citations:    Fields:    Translation:Humans
    7. Kamine TH, Dhanani H, Wilcox S, Kelly E, Alouidor R, Kramer K, Carey Y, Ryb G, Putnam AT, Winston E, Cohen J. American Helicopter Emergency Medical Service Pilots Report to Work Despite High Rates of Sleepiness. Air Med J. 2022 Sep-Oct; 41(5):432-434. PMID: 36153138.
      Citations:    Fields:    Translation:Humans
    8. Mahadeo A, Yeung CK, Himmelfarb J, Kelly EJ. Kidney microphysiological models for nephrotoxicity assessment. Curr Opin Toxicol. 2022 Jun; 30. PMID: 35495549.
      Citations:    
    9. Lidberg KA, Muthusamy S, Adil M, Mahadeo A, Yang J, Patel RS, Wang L, Bammler TK, Reichel J, Yeung CK, Himmelfarb J, Kelly EJ, Akilesh S. Serum Protein Exposure Activates a Core Regulatory Program Driving Human Proximal Tubule Injury. J Am Soc Nephrol. 2022 05; 33(5):949-965. PMID: 35197326.
      Citations: 6     Fields:    Translation:HumansAnimals
    10. Imaoka T, Huang W, Shum S, Hailey DW, Chang SY, Chapron A, Yeung CK, Himmelfarb J, Isoherranen N, Kelly EJ. Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system. Sci Rep. 2021 11 01; 11(1):21356. PMID: 34725352.
      Citations: 7     Fields:    Translation:HumansCells
    11. Arian CM, Imaoka T, Yang J, Kelly EJ, Thummel KE. Gutsy science: In vitro systems of the human intestine to model oral drug disposition. Pharmacol Ther. 2022 02; 230:107962. PMID: 34478775.
      Citations: 1     Fields:    Translation:Humans
    12. Van Ness KP, Cesar F, Yeung CK, Himmelfarb J, Kelly EJ. Microphysiological systems in absorption, distribution, metabolism, and elimination sciences. Clin Transl Sci. 2022 01; 15(1):9-42. PMID: 34378335.
      Citations: 5     Fields:    
    13. Lidberg KA, Annalora AJ, Jozic M, Elson DJ, Wang L, Bammler TK, Ramm S, Monteiro MB, Himmelfarb J, Marcus CB, Iversen PL, Kelly EJ. Author Correction: Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Sci Rep. 2021 May 17; 11(1):10711. PMID: 34002000.
      Citations:    Fields:    
    14. Lidberg KA, Annalora AJ, Jozic M, Elson DJ, Wang L, Bammler TK, Ramm S, Monteiro MB, Himmelfarb J, Marcus CB, Iversen PL, Kelly EJ. Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Sci Rep. 2021 02 25; 11(1):4722. PMID: 33633318.
      Citations: 3     Fields:    Translation:HumansCells
    15. Nieskens TTG, Persson M, Kelly EJ, Sj?gren AK. A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization-Dependent Cisplatin Toxicity. Drug Metab Dispos. 2020 12; 48(12):1303-1311. PMID: 33020068.
      Citations: 11     Fields:    Translation:HumansCells
    16. Basit A, Neradugomma NK, Wolford C, Fan PW, Murray B, Takahashi RH, Khojasteh SC, Smith BJ, Heyward S, Totah RA, Kelly EJ, Prasad B. Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human. Mol Pharm. 2020 11 02; 17(11):4114-4124. PMID: 32955894.
      Citations: 18     Fields:    Translation:Humans
    17. Imaoka T, Yang J, Wang L, McDonald MG, Afsharinejad Z, Bammler TK, Van Ness K, Yeung CK, Rettie AE, Himmelfarb J, Kelly EJ. Microphysiological system modeling of ochratoxin A-associated nephrotoxicity. Toxicology. 2020 11; 444:152582. PMID: 32905824.
      Citations: 14     Fields:    Translation:HumansCells
    18. Patel RC, Stalter RM, Thomas KK, Tamraz B, Blue SW, Erikson DW, Kim CJ, Kelly EJ, Nanda K, Kourtis AP, Lingappa JR, Mugo N, Baeten JM, Scarsi KK. A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda. AIDS. 2019 11 01; 33(13):1995-2004. PMID: 31306173.
      Citations: 8     Fields:    Translation:Humans
    19. Lyu HG, Castillo-Angeles M, Bruno M, Cooper Z, Nehra D, Nitzschke SL, Askari R, Kelly E, Shimizu N, Riviello R, Salim A, Havens JM. Outcomes of a low-osmolar water-soluble contrast pathway in small bowel obstruction. J Trauma Acute Care Surg. 2019 09; 87(3):630-635. PMID: 31205220.
      Citations: 2     Fields:    Translation:Humans
    20. Sachar M, Kelly EJ, Unadkat JD. Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells. AAPS J. 2019 03 27; 21(3):45. PMID: 30919109.
      Citations: 9     Fields:    Translation:HumansCells
    21. Taghavi S, Castillo-Angeles M, Uribe-Leitz T, Hirji S, Armand P, Nehra D, Cooper Z, Kelly E, Havens J, Haider A, Salim A, Askari R. Emergency general surgery procedures in hematopoietic stem cell transplant recipients. Am J Surg. 2019 11; 218(5):972-977. PMID: 30862354.
      Citations:    Fields:    Translation:HumansPHPublic Health
    22. Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G. Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. Drug Metab Dispos. 2018 11; 46(11):1692-1702. PMID: 30076203.
      Citations: 21     Fields:    Translation:HumansAnimals
    23. Chapron BD, Chapron A, Phillips B, Okoli MC, Shen DD, Kelly EJ, Himmelfarb J, Thummel KE. Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system ALTEX. 2018; 35(4):504-515. PMID: 29999169.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    24. Yorkgitis BK, Olufajo OA, Gurien LA, Kelly E, Salim A, Askari R. Risk factors for prolonged need for percutaneous endoscopic gastrostomy (PEG) tubes in adult trauma patients: Experience of a level 1 trauma. Surgery. 2018 12; 164(6):1259-1262. PMID: 29983158.
      Citations:    Fields:    Translation:Humans
    25. Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL. Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. JCI Insight. 2017 11 16; 2(22). PMID: 29202460.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    26. Billington S, Ray AS, Salphati L, Xiao G, Chu X, Humphreys WG, Liao M, Lee CA, Mathias A, Hop CECA, Rowbottom C, Evers R, Lai Y, Kelly EJ, Prasad B, Unadkat JD. Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics. Drug Metab Dispos. 2018 02; 46(2):189-196. PMID: 29138286.
      Citations: 20     Fields:    Translation:Humans
    27. Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ. Microphysiological Systems to Assess Nonclinical Toxicity. Curr Protoc Toxicol. 2017 Aug 04; 73:14.18.1-14.18.28. PMID: 28777442.
      Citations: 9     Fields:    Translation:Humans
    28. Lockhart CM, Smith TB, Yang P, Naidu M, Rettie AE, Nath A, Weleber R, Kelly EJ. Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2. Br J Ophthalmol. 2018 02; 102(2):187-194. PMID: 28698241.
      Citations: 9     Fields:    Translation:Humans
    29. Weber EJ, Himmelfarb J, Kelly EJ. Concise Review: Current and Emerging Biomarkers of Nephrotoxicity. Curr Opin Toxicol. 2017 Jun; 4:16-21. PMID: 29057384.
      Citations:    
    30. Prasad B, Johnson K, Billington S, Lee C, Chung GW, Brown CD, Kelly EJ, Himmelfarb J, Unadkat JD. Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics. Drug Metab Dispos. 2016 12; 44(12):1920-1924. PMID: 27621205.
      Citations: 47     Fields:    Translation:HumansCells
    31. Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ. Development of a microphysiological model of human kidney proximal tubule function. Kidney Int. 2016 09; 90(3):627-37. PMID: 27521113.
      Citations: 86     Fields:    Translation:HumansCells
    32. Wang L, Collins C, Kelly EJ, Chu X, Ray AS, Salphati L, Xiao G, Lee C, Lai Y, Liao M, Mathias A, Evers R, Humphreys W, Hop CE, Kumer SC, Unadkat JD. Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics. Drug Metab Dispos. 2016 11; 44(11):1752-1758. PMID: 27543206.
      Citations: 44     Fields:    Translation:HumansCells
    33. Parkinson OT, Teitelbaum AM, Whittington D, Kelly EJ, Rettie AE. Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity. Drug Metab Dispos. 2016 10; 44(10):1598-602. PMID: 27468999.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    34. Olufajo OA, Yorkgitis BK, Cooper Z, Rios-Diaz A, Metcalfe D, Havens JM, Kelly E, Haider AH, Gates JD, Salim A. How long should we fear? Long-term risk of venous thromboembolism in patients with traumatic brain injury. J Trauma Acute Care Surg. 2016 07; 81(1):71-8. PMID: 27015575.
      Citations: 2     Fields:    Translation:Humans
    35. Farooq M, Kelly EJ, Unadkat JD. CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids. Drug Metab Dispos. 2016 May; 44(5):750-7. PMID: 26965986.
      Citations: 10     Fields:    Translation:HumansCells
    36. Olufajo OA, Tulebaev S, Javedan H, Gates J, Wang J, Duarte M, Kelly E, Lilley E, Salim A, Cooper Z. Integrating Geriatric Consults into Routine Care of Older Trauma Patients: One-Year Experience of a Level I Trauma Center. J Am Coll Surg. 2016 06; 222(6):1029-35. PMID: 26968324.
      Citations: 22     Fields:    Translation:HumansCTClinical Trials
    37. Olufajo OA, Metcalfe D, Rios-Diaz A, Lilley E, Havens JM, Kelly E, Weissman JS, Haider AH, Salim A, Cooper Z. Does Hospital Experience Rather than Volume Improve Outcomes in Geriatric Trauma Patients? J Am Coll Surg. 2016 07; 223(1):32-40.e1. PMID: 27055588.
      Citations: 4     Fields:    Translation:Humans
    38. Havens JM, Do WS, Kaafarani H, Mesar T, Reznor G, Cooper Z, Askari R, Kelly E, Columbus AB, Gates JD, Haider AH, Salim A. Explaining the excess morbidity of emergency general surgery: packed red blood cell and fresh frozen plasma transfusion practices are associated with major complications in nonmassively transfused patients. Am J Surg. 2016 Apr; 211(4):656-663.e4. PMID: 26860622.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    39. Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS. A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol. 2016 Apr; 27(4):1015-28. PMID: 26260164.
      Citations: 40     Fields:    Translation:HumansCells
    40. Kelly E, Kiemele ER, Reznor G, Havens JM, Cooper Z, Salim A. Trauma systems are associated with increased level 3 trauma centers. J Surg Res. 2015 Oct; 198(2):489-93. PMID: 25986210.
      Citations: 2     Fields:    
    41. Havens JM, Peetz AB, Do WS, Cooper Z, Kelly E, Askari R, Reznor G, Salim A. The excess morbidity and mortality of emergency general surgery. J Trauma Acute Care Surg. 2015 Feb; 78(2):306-11. PMID: 25757115.
      Citations: 105     Fields:    Translation:HumansPHPublic Health
    42. Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q. Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014 Dec 15; 92(4):690-700. PMID: 25450675.
      Citations: 15     Fields:    Translation:HumansCells
    43. Lockhart CM, Nakano M, Rettie AE, Kelly EJ. Generation and characterization of a murine model of Bietti crystalline dystrophy. Invest Ophthalmol Vis Sci. 2014 Aug 12; 55(9):5572-81. PMID: 25118264.
      Citations: 22     Fields:    Translation:Animals
    44. Lee N, Hebert MF, Prasad B, Easterling TR, Kelly EJ, Unadkat JD, Wang J. Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy. Drug Metab Dispos. 2013 Dec; 41(12):2225-32. PMID: 24101703.
      Citations: 34     Fields:    Translation:HumansAnimals
    45. van der Wilden GM, Velmahos GC, Joseph DK, Jacobs L, Debusk MG, Adams CA, Gross R, Burkott B, Agarwal S, Maung AA, Johnson DC, Gates J, Kelly E, Michaud Y, Charash WE, Winchell RJ, Desjardins SE, Rosenblatt MS, Gupta S, Gaeta M, Chang Y, de Moya MA. Successful nonoperative management of the most severe blunt renal injuries: a multicenter study of the research consortium of New England Centers for Trauma. JAMA Surg. 2013 Oct; 148(10):924-31. PMID: 23945834.
      Citations: 29     Fields:    Translation:Humans
    46. Topletz AR, Le HN, Lee N, Chapman JD, Kelly EJ, Wang J, Isoherranen N. Hepatic Cyp2d and Cyp26a1 mRNAs and activities are increased during mouse pregnancy. Drug Metab Dispos. 2013 Feb; 41(2):312-9. PMID: 23150428.
      Citations: 10     Fields:    Translation:AnimalsCells
    47. Kelly E, Rogers SO. Graduate medical education in trauma/critical care and acute care surgery: defining goals for a new workforce. Surg Clin North Am. 2012 Aug; 92(4):1055-64, x. PMID: 22850162.
      Citations: 3     Fields:    
    48. Ho MT, Kelly EJ, Bodor M, Bui T, Kowdley KV, Ho RJ. Novel cytochrome P450-2D6 promoter sequence variations in hepatitis C positive and negative subjects. Ann Hepatol. 2011 Jul-Sep; 10(3):327-32. PMID: 21677335.
      Citations: 2     Fields:    Translation:HumansCells
    49. Crouthamel MH, Kelly EJ, Ho RJ. Development and characterization of transgenic mouse models for conditional gene knockout in the blood-brain and blood-CSF barriers. Transgenic Res. 2012 Feb; 21(1):113-30. PMID: 21538071.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    50. Kelly EJ, Nakano M, Rohatgi P, Yarov-Yarovoy V, Rettie AE. Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states. Mol Interv. 2011 Apr; 11(2):124-32. PMID: 21540472.
      Citations: 22     Fields:    Translation:HumansAnimals
    51. Eyal S, Easterling TR, Carr D, Umans JG, Miodovnik M, Hankins GD, Clark SM, Risler L, Wang J, Kelly EJ, Shen DD, Hebert MF. Pharmacokinetics of metformin during pregnancy. Drug Metab Dispos. 2010 May; 38(5):833-40. PMID: 20118196.
      Citations: 75     Fields:    Translation:Humans
    52. Nakano M, Kelly EJ, Rettie AE. Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. Drug Metab Dispos. 2009 Nov; 37(11):2119-22. PMID: 19661213.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    53. Havens JM, Kelly E, Patel V. A 78-year-old man with an elevated hemidiaphragm following trauma. Chest. 2008 Dec; 134(6):1336-1339. PMID: 19059966.
      Citations:    Fields:    Translation:Humans
    54. Salama NN, Kelly EJ, Bui T, Ho RJ. The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice. J Pharm Sci. 2005 Jun; 94(6):1216-25. PMID: 15858856.
      Citations: 15     Fields:    Translation:Animals
    55. Bodor M, Kelly EJ, Ho RJ. Characterization of the human MDR1 gene. AAPS J. 2005 Feb 16; 7(1):E1-5. PMID: 16146331.
      Citations: 42     Fields:    Translation:HumansCells
    56. McConnachie LA, Bodor M, Phillips B, Kelly EJ, Shen DD, Ho RJ. An RT-PCR-based strategy to estimate full-length CYP2D6 mRNA copy number. Genet Test. 2004; 8(3):313-8. PMID: 15727256.
      Citations: 1     Fields:    Translation:Humans
    57. Hashmi S, Kelly E, Rogers SO, Gates J. Urinary tract infection in surgical patients. Am J Surg. 2003 Jul; 186(1):53-6. PMID: 12842750.
      Citations: 6     Fields:    Translation:Humans
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