Header Logo

Leandro de Souza Silva PHD

TitleInstructor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-1720
vCardDownload vCard
    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases And Immunology


    Collapse Biography 
    Collapse education and training
    Veiga de Almeida University, Rio de Janeiro, , BrazilBSBiological Science
    Federal University of Rio de Janeiro, Rio de Janeiro, RJ, BrazilPHD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lewis LA, Gulati S, Zelek WM, Morgan BP, Song WC, Zheng B, Nowak N, DeOliveira RB, Sanchez B, DeSouza Silva L, Schuurman J, Beurskens F, Ram S, Rice PA. Efficacy of an experimental gonococcal lipooligosaccharide mimitope vaccine requires terminal complement. J Infect Dis. 2021 Dec 31. PMID: 34971376.
      Citations:    Fields:    
    2. Camila Wendt, Wanderley de Souza, Alessandro Pinheiro, Leandro Silva, Ana Acácia de Sá Pinheiro, Raynald Gauvin, and Kildare Miranda. High-Resolution Electron Microscopy Analysis of Malaria Hemozoin Crystals Reveals New Aspects of Crystal Growth and Elemental Composition. High-Resolution Electron Microscopy Analysis of Malaria Hemozoin Crystals Reveals New Aspects of Crystal Growth and Elemental Composition. 2021; 10(21):5521-5533. View Publication.
    3. Pontes KAO, Silva LS, Santos EC, Pinheiro AS, Teixeira DE, Peruchetti DB, Silva-Aguiar RP, Wendt CHC, Miranda KR, Coelho-de-Souza AN, Leal-Cardoso JH, Caruso-Neves C, Pinheiro AAS. Eugenol disrupts Plasmodium falciparum intracellular development during the erythrocytic cycle and protects against cerebral malaria. Biochim Biophys Acta Gen Subj. 2021 03; 1865(3):129813. PMID: 33321150.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Gómez F, Silva LS, Teixeira DE, Agero U, Pinheiro AAS, Viana NB, Pontes B. Plasmodium falciparum maturation across the intra-erythrocytic cycle shifts the soft glassy viscoelastic properties of red blood cells from a liquid-like towards a solid-like behavior. Exp Cell Res. 2020 12 15; 397(2):112370. PMID: 33186602.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Rodrigues DAS, Prestes EB, Gama AMS, Silva LS, Pinheiro AAS, Ribeiro JMC, Campos RMP, Pimentel-Coelho PM, De Souza HS, Dicko A, Duffy PE, Fried M, Francischetti IMB, Saraiva EM, Paula-Neto HA, Bozza MT. CXCR4 and MIF are required for neutrophil extracellular trap release triggered by Plasmodium-infected erythrocytes. PLoS Pathog. 2020 08; 16(8):e1008230. PMID: 32797076.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    6. Gómez F, Silva LS, Araújo GRS, Frases S, Pinheiro AAS, Agero U, Pontes B, Viana NB. Effect of cell geometry in the evaluation of erythrocyte viscoelastic properties. Phys Rev E. 2020 Jun; 101(6-1):062403. PMID: 32688571.
      Citations: 2     Fields:    Translation:HumansCells
    7. Teixeira DE, Peruchetti DB, Silva LS, Silva-Aguiar RP, Oquendo MB, Silva-Filho JL, Takiya CM, Leal-Cardoso JH, Pinheiro AAS, Caruso-Neves C. Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway. PLoS One. 2019; 14(4):e0215871. PMID: 31002704.
      Citations:    
    8. Silva LS, Pinheiro AS, Teixeira DE, Silva-Aguiar RP, Peruchetti DB, Scharfstein J, Caruso-Neves C, Pinheiro AAS. Kinins Released by Erythrocytic Stages of Plasmodium falciparum Enhance Adhesion of Infected Erythrocytes to Endothelial Cells and Increase Blood Brain Barrier Permeability via Activation of Bradykinin Receptors. Front Med (Lausanne). 2019; 6:75. PMID: 31058153.
      Citations:    
    9. Silva LS, Peruchetti DB, Silva-Aguiar RP, Abreu TP, Dal-Cheri BKA, Takiya CM, Souza MC, Henriques MG, Pinheiro AAS, Caruso-Neves C. The angiotensin II/AT1 receptor pathway mediates malaria-induced acute kidney injury. PLoS One. 2018; 13(9):e0203836. PMID: 30204779.
      Citations:    
    10. Ribeiro MC, Peruchetti DB, Silva LS, Silva-Filho JL, Souza MC, Henriques MDG, Caruso-Neves C, Pinheiro AAS. LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion. Front Mol Biosci. 2018; 5:67. PMID: 30073169.
      Citations:    
    11. Silva LS, Prado GC, Quintana PG, Heise N, Miranda KR, Torres EJL, Persechini PM, de Sá Pinheiro AA, Schachter J. Plasmodium falciparum invasion and intraerythrocytic development are impaired by 2', 3'-dialdehyde adenosine. Microbes Infect. 2018 03; 20(3):205-211. PMID: 29253662.
      Citations:    
    12. Silva AF, Torres MT, Silva LS, Alves FL, de Sá Pinheiro AA, Miranda A, Capurro ML, de la Fuente-Nunez C, Oliveira VX. Angiotensin II-derived constrained peptides with antiplasmodial activity and suppressed vasoconstriction. Sci Rep. 2017 10 30; 7(1):14326. PMID: 29085013.
      Citations:    
    13. Silva AF, Oliveira VX, Silva LS, Pinheiro AAS, Ciscato LFML. Antiplasmodial activity of alkyl-substituted 1,2-dioxetanes against Plasmodium falciparum. Bioorg Med Chem Lett. 2016 10 15; 26(20):5007-5008. PMID: 27623546.
      Citations:    
    14. Silva LS, Peruchetti DB, Silva CTF, Ferreira-DaSilva AT, Perales J, Caruso-Neves C, Pinheiro AAS. Interaction between bradykinin B2 and Ang-(1-7) Mas receptors regulates erythrocyte invasion by Plasmodium falciparum. Biochim Biophys Acta. 2016 11; 1860(11 Pt A):2438-2444. PMID: 27431603.
      Citations:    
    15. Silva-Filho JL, Peruchetti DB, Moraes-Santos F, Landgraf SS, Silva LS, Sirtoli GM, Zamith-Miranda D, Takiya CM, Pinheiro AA, Diaz BL, Caruso-Neves C. Group V Secretory Phospholipase A2 Is Involved in Tubular Integrity and Sodium Handling in the Kidney. PLoS One. 2016; 11(1):e0147785. PMID: 26820468.
      Citations:    
    16. Silva LS, Silva-Filho JL, Caruso-Neves C, Pinheiro AA. New Concepts in Malaria Pathogenesis: The Role of the Renin-Angiotensin System. Front Cell Infect Microbiol. 2015; 5:103. PMID: 26779452.
      Citations:    
    17. Silva AF, Torres MD, Silva Lde S, Alves FL, Pinheiro AA, Miranda A, Capurro ML, Oliveira VX. New linear antiplasmodial peptides related to angiotensin II. Malar J. 2015 Nov 04; 14:433. PMID: 26537730.
      Citations:    
    18. Lopes NS, Yoshitake AM, Silva AF, Oliveira VX, Silva LS, Pinheiro AA, Ciscato LF. Antimalarial Effect of 3-Methoxy-1,2-Dioxetanes on the Erythrocytic Cycle of Plasmodium falciparum. Chem Biol Drug Des. 2015 Dec; 86(6):1373-7. PMID: 26032859.
      Citations:    
    19. Silva AF, Alves FL, Pedron CN, Torres MD, Silva LS, Pinheiro AA, Miranda A, Oliveira VX. Anti-plasmodial activity of bradykinin and analogs. Bioorg Med Chem Lett. 2015 Aug 15; 25(16):3311-3. PMID: 26077496.
      Citations:    
    20. Silva AF, de Souza Silva L, Alves FL, Der TorossianTorres M, de SáPinheiro AA, Miranda A, LaraCapurro M, Oliveira VX. Effects of the angiotensin II Ala-scan analogs in erythrocytic cycle of Plasmodium falciparum (in vitro) and Plasmodium gallinaceum (ex vivo). Exp Parasitol. 2015 Jun; 153:1-7. PMID: 25720804.
      Citations:    
    21. Souza MC, Pádua TA, Torres ND, Souza Costa MF, Candéa AP, Maramaldo T, Seito LN, Penido C, Estato V, Antunes B, Silva L, Pinheiro AA, Caruso-Neves C, Tibiriçá E, Carvalho L, Henriques MG. Lipoxin A4 attenuates endothelial dysfunction during experimental cerebral malaria. Int Immunopharmacol. 2015 Feb; 24(2):400-407. PMID: 25576659.
      Citations:    
    22. Torres MD, Silva AF, de Souza Silva L, de Sá Pinheiro AA, Oliveira VX. Angiotensin II restricted analogs with biological activity in the erythrocytic cycle of Plasmodium falciparum. J Pept Sci. 2015 Jan; 21(1):24-8. PMID: 25420772.
      Citations:    
    23. Landgraf SS, Silva LS, Peruchetti DB, Sirtoli GM, Moraes-Santos F, Portella VG, Silva-Filho JL, Pinheiro CS, Abreu TP, Takiya CM, Benjamin CF, Pinheiro AA, Canetti C, Caruso-Neves C. 5-Lypoxygenase products are involved in renal tubulointerstitial injury induced by albumin overload in proximal tubules in mice. PLoS One. 2014; 9(10):e107549. PMID: 25302946.
      Citations:    
    24. Alvarez CL, Schachter J, de Sá Pinheiro AA, Silva Lde S, Verstraeten SV, Persechini PM, Schwarzbaum PJ. Regulation of extracellular ATP in human erythrocytes infected with Plasmodium falciparum. PLoS One. 2014; 9(5):e96216. PMID: 24858837.
      Citations:    
    25. Abreu TP, Silva LS, Takiya CM, Souza MC, Henriques MG, Pinheiro AA, Caruso-Neves C. Mice rescued from severe malaria are protected against renal injury during a second kidney insult. PLoS One. 2014; 9(4):e93634. PMID: 24736406.
      Citations:    
    26. Silva-Filho JL, Souza MC, Ferreira-Dasilva CT, Silva LS, Costa MF, Padua TA, Henriques Md, Morrot A, Savino W, Caruso-Neves C, Pinheiro AA. Angiotensin II is a new component involved in splenic T lymphocyte responses during Plasmodium berghei ANKA infection. PLoS One. 2013; 8(4):e62999. PMID: 23646169.
      Citations:    
    27. Calabrese KS, Silva LS, Hardoim DJ, Souza CS, Abreu-Silva AL. Ocular experimental leishmaniasis in C57BL/10 and BALB/c mice induced by Leishmania amazonensis infection. Exp Parasitol. 2013 Feb; 133(2):156-61. PMID: 23201219.
      Citations:    
    28. Calabrese KS, Silva LS, Carvalho LO, Hardoim DJ, Silva-Almeida Md, Mortara RA, Souza CS. Infection of retinal epithelial cells with L. amazonensis impacts in extracellular matrix proteins. Parasitol Res. 2011 Sep; 109(3):727-36. PMID: 21494843.
      Citations:    
    29. Saraiva VB, de Souza Silva L, Ferreira-DaSilva CT, da Silva-Filho JL, Teixeira-Ferreira A, Perales J, Souza MC, Henriques Md, Caruso-Neves C, de Sá Pinheiro AA. Impairment of the Plasmodium falciparum erythrocytic cycle induced by angiotensin peptides. PLoS One. 2011 Feb 18; 6(2):e17174. PMID: 21364758.
      Citations:    
    For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
    de Souza Silva's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (140)
    Explore
    _
    Co-Authors (4)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _