Malaria, Cerebral

"Malaria, Cerebral" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A condition characterized by somnolence or coma in the presence of an acute infection with PLASMODIUM FALCIPARUM (and rarely other Plasmodium species). Initial clinical manifestations include HEADACHES; SEIZURES; and alterations of mentation followed by a rapid progression to COMA. Pathologic features include cerebral capillaries filled with parasitized erythrocytes and multiple small foci of cortical and subcortical necrosis. (From Adams et al., Principles of Neurology, 6th ed, p136)

Descriptor ID	D016779
MeSH Number(s)	C03.105.300.500 C03.752.530.620 C10.228.228.205.300.500
Concept/Terms	Malaria, Cerebral Malaria, Cerebral Cerebral Malaria Malaria Meningitis Malaria Meningitis Meningitis, Malaria

Below are MeSH descriptors whose meaning is more general than "Malaria, Cerebral".

Diseases [C]
Parasitic Diseases [C03]
Central Nervous System Parasitic Infections [C03.105]
Central Nervous System Protozoal Infections [C03.105.300]
Malaria, Cerebral [C03.105.300.500]
Protozoan Infections [C03.752]
Malaria [C03.752.530]
Malaria, Cerebral [C03.752.530.620]
Nervous System Diseases [C10]
Central Nervous System Diseases [C10.228]
Central Nervous System Infections [C10.228.228]
Central Nervous System Parasitic Infections [C10.228.228.205]
Central Nervous System Protozoal Infections [C10.228.228.205.300]
Malaria, Cerebral [C10.228.228.205.300.500]

Below are MeSH descriptors whose meaning is related to "Malaria, Cerebral".

Below are MeSH descriptors whose meaning is more specific than "Malaria, Cerebral".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Malaria, Cerebral" by people in this website by year, and whether "Malaria, Cerebral" was a major or minor topic of these publications.

Bar chart showing 14 publications over 11 distinct years, with a maximum of 4 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	1	0	1
2013	0	1	1
2014	1	0	1
2015	1	0	1
2016	1	0	1
2018	1	0	1
2019	1	0	1
2020	4	0	4
2022	1	0	1
2023	1	0	1
2024	1	0	1

Below are the most recent publications written about "Malaria, Cerebral" by people in Profiles.

Silva AF, Torres MDT, Silva LS, Alves FL, Miranda A, Oliveira VX, de la Fuente-Nunez C, Pinheiro AAS. Synthetic angiotensin II peptide derivatives confer protection against cerebral and severe non-cerebral malaria in murine models. Sci Rep. 2024 02 26; 14(1):4682.

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Alves SAS, Teixeira DE, Peruchetti DB, Silva LS, Brand?o LFP, Caruso-Neves C, Pinheiro AAS. Bradykinin produced during Plasmodium falciparum erythrocytic cycle drives monocyte adhesion to human brain microvascular endothelial cells. Brain Res. 2024 01 01; 1822:148669.

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Santos ECD, Silva LS, Pinheiro AS, Teixeira DE, Peruchetti DB, Silva-Aguiar RP, Wendt CHC, Miranda KR, Coelho-de-Souza AN, Leal-Cardoso JH, Caruso-Neves C, Pinheiro AAS. The monoterpene 1,8-cineole prevents cerebral edema in a murine model of severe malaria. PLoS One. 2022; 17(5):e0268347.

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Pontes KAO, Silva LS, Santos EC, Pinheiro AS, Teixeira DE, Peruchetti DB, Silva-Aguiar RP, Wendt CHC, Miranda KR, Coelho-de-Souza AN, Leal-Cardoso JH, Caruso-Neves C, Pinheiro AAS. Eugenol disrupts Plasmodium falciparum intracellular development during the erythrocytic cycle and protects against cerebral malaria. Biochim Biophys Acta Gen Subj. 2021 03; 1865(3):129813.

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Pereira LMN, Assis PA, de Ara?jo NM, Durso DF, Junqueira C, Ata?de MA, Pereira DB, Lien E, Fitzgerald KA, Zamboni DS, Golenbock DT, Gazzinelli RT. Caspase-8 mediates inflammation and disease in rodent malaria. Nat Commun. 2020 09 14; 11(1):4596.

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Kaine J, Moran-Guiati J, Tanch J, Clyne B. Cerebral and Plasmodium ovale Malaria in Rhode Island. R I Med J (2013). 2020 Aug 03; 103(6):64-67.

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Assis PA, Fernandes Durso D, Chacon Cavalcante F, Zaniratto R, Carvalho-Silva AC, Cunha-Neto E, Golenbock DT, Rodrigues Pinto Ferreira L, Tostes Gazzinelli R. Integrative analysis of microRNA and mRNA expression profiles of monocyte-derived dendritic cells differentiation during experimental cerebral malaria. J Leukoc Biol. 2020 10; 108(4):1183-1197.

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Hirako IC, Assis PA, Galv?o-Filho B, Luster AD, Antonelli LR, Gazzinelli RT. Monocyte-derived dendritic cells in malaria. Curr Opin Microbiol. 2019 12; 52:139-150.

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Strangward P, Haley MJ, Albornoz MG, Barrington J, Shaw T, Dookie R, Zeef L, Baker SM, Winter E, Tzeng TC, Golenbock DT, Cruickshank SM, Allan SM, Craig A, Liew FY, Brough D, Couper KN. Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):7404-7409.

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Clarke GM, Rockett K, Kivinen K, Hubbart C, Jeffreys AE, Rowlands K, Jallow M, Conway DJ, Bojang KA, Pinder M, Usen S, Sisay-Joof F, Sirugo G, Toure O, Thera MA, Konate S, Sissoko S, Niangaly A, Poudiougou B, Mangano VD, Bougouma EC, Sirima SB, Modiano D, Amenga-Etego LN, Ghansah A, Koram KA, Wilson MD, Enimil A, Evans J, Amodu OK, Olaniyan S, Apinjoh T, Mugri R, Ndi A, Ndila CM, Uyoga S, Macharia A, Peshu N, Williams TN, Manjurano A, Sep?lveda N, Clark TG, Riley E, Drakeley C, Reyburn H, Nyirongo V, Kachala D, Molyneux M, Dunstan SJ, Phu NH, Quyen NN, Thai CQ, Hien TT, Manning L, Laman M, Siba P, Karunajeewa H, Allen S, Allen A, Davis TM, Michon P, Mueller I, Molloy SF, Campino S, Kerasidou A, Cornelius VJ, Hart L, Shah SS, Band G, Spencer CC, Agbenyega T, Achidi E, Doumbo OK, Farrar J, Marsh K, Taylor T, Kwiatkowski DP. Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia. Elife. 2017 01 09; 6.

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