Glycogen Synthase Kinase 3 beta

"Glycogen Synthase Kinase 3 beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A glycogen synthase kinase-3 type enzyme that functions in ENERGY METABOLISM; EMBRYONIC DEVELOPMENT; and NEUROGENESIS. It is also involved in PROTEIN BIOSYNTHESIS and regulates cell growth and proliferation as a component of the WNT SIGNALING PATHWAY and other signaling pathways. Certain polymorphisms in the GSK3B gene have been associated with PARKINSON DISEASE; ALZHEIMER DISEASE; and BIPOLAR DISORDER.

Descriptor ID	D000071679
MeSH Number(s)	D05.500.117.875.500 D08.811.913.696.620.682.700.429.500.500 D08.811.913.696.620.682.700.646.625.500 D12.644.360.300.500.500 D12.776.476.081.875.500 D12.776.476.300.500.500
Concept/Terms	Glycogen Synthase Kinase 3 beta Glycogen Synthase Kinase 3 beta GSK-3beta GSK 3beta GSK3beta GSK3B Protein

Below are MeSH descriptors whose meaning is more general than "Glycogen Synthase Kinase 3 beta".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Axin Signaling Complex [D05.500.117]
Glycogen Synthase Kinase 3 [D05.500.117.875]
Glycogen Synthase Kinase 3 beta [D05.500.117.875.500]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429]
Glycogen Synthase Kinase 3 [D08.811.913.696.620.682.700.429.500]
Glycogen Synthase Kinase 3 beta [D08.811.913.696.620.682.700.429.500.500]
Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
Glycogen Synthase Kinase 3 [D08.811.913.696.620.682.700.646.625]
Glycogen Synthase Kinase 3 beta [D08.811.913.696.620.682.700.646.625.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Glycogen Synthase Kinases [D12.644.360.300]
Glycogen Synthase Kinase 3 [D12.644.360.300.500]
Glycogen Synthase Kinase 3 beta [D12.644.360.300.500.500]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Axin Signaling Complex [D12.776.476.081]
Glycogen Synthase Kinase 3 [D12.776.476.081.875]
Glycogen Synthase Kinase 3 beta [D12.776.476.081.875.500]
Glycogen Synthase Kinases [D12.776.476.300]
Glycogen Synthase Kinase 3 [D12.776.476.300.500]
Glycogen Synthase Kinase 3 beta [D12.776.476.300.500.500]

Below are MeSH descriptors whose meaning is related to "Glycogen Synthase Kinase 3 beta".

Below are MeSH descriptors whose meaning is more specific than "Glycogen Synthase Kinase 3 beta".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Glycogen Synthase Kinase 3 beta" by people in this website by year, and whether "Glycogen Synthase Kinase 3 beta" was a major or minor topic of these publications.

Bar chart showing 20 publications over 14 distinct years, with a maximum of 3 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2005	0	2	2
2006	0	2	2
2007	0	1	1
2008	0	1	1
2013	0	3	3
2014	0	1	1
2015	0	2	2
2016	0	2	2
2017	0	1	1
2019	0	1	1
2020	1	0	1
2021	1	0	1
2024	0	1	1

Below are the most recent publications written about "Glycogen Synthase Kinase 3 beta" by people in Profiles.

Mohanty G, Sanchez-Cardenas C, Paudel B, Tourzani DA, Salicioni AM, Santi CM, Gervasi MG, Pilsner JR, Darszon A, Visconti PE. Differential role of bovine serum albumin and HCO3- in the regulation of GSK3 alpha during mouse sperm capacitation. Mol Hum Reprod. 2024 Feb 29; 30(3).

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Zhang CH, Liu H, Zhao WL, Zhao WX, Zhou HM, Shao RG. G3BP1 promotes human breast cancer cell proliferation through coordinating with GSK-3? and stabilizing ?-catenin. Acta Pharmacol Sin. 2021 11; 42(11):1900-1912.

View in: PubMed
Xue J, Zhang L, Xie X, Gao Y, Jiang L, Wang J, Wang Y, Gao R, Yu J, Xiao H. Prenatal bisphenol A exposure contributes to Tau pathology: Potential roles of CDK5/GSK3?/PP2A axis in BPA-induced neurotoxicity. Toxicology. 2020 05 30; 438:152442.

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Chen L, Zhou L, Yu P, Fang F, Jiang L, Fei J, Xiao H, Wang J. Methamphetamine exposure upregulates the amyloid precursor protein and hyperphosphorylated tau expression: The roles of insulin signaling in SH-SY5Y cell line. J Toxicol Sci. 2019; 44(7):493-503.

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Wang T, Xie C, Yu P, Fang F, Zhu J, Cheng J, Gu A, Wang J, Xiao H. Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer's Disease-like Neurotoxicity. Sci Rep. 2017 08 08; 7(1):7497.

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Goyal A, Linskey KR, Kay J, Duncan LM, Nazarian RM. Differential Expression of Hedgehog and Snail in Cutaneous Fibrosing Disorders: Implications for Targeted Inhibition. Am J Clin Pathol. 2016 Dec; 146(6):709-717.

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Orme MH, Liccardi G, Moderau N, Feltham R, Wicky-John S, Tenev T, Aram L, Wilson R, Bianchi K, Morris O, Monteiro Domingues C, Robertson D, Tare M, Wepf A, Williams D, Bergmann A, Gstaiger M, Arama E, Ribeiro PS, Meier P. The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles. Nat Commun. 2016 Mar 10; 7:10972.

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Jurczyk A, Nowosielska A, Przewozniak N, Aryee KE, DiIorio P, Blodgett D, Yang C, Campbell-Thompson M, Atkinson M, Shultz L, Rittenhouse A, Harlan D, Greiner D, Bortell R. Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ?-cell function via glycogen synthase kinase-3?. FASEB J. 2016 Feb; 30(2):983-93.

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Fang F, Chen D, Yu P, Qian W, Zhou J, Liu J, Gao R, Wang J, Xiao H. Effects of Bisphenol A on glucose homeostasis and brain insulin signaling pathways in male mice. Gen Comp Endocrinol. 2015 Feb 01; 212:44-50.

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Landis J, Shaw LM. Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3? to regulate aerobic glycolysis. J Biol Chem. 2014 Jun 27; 289(26):18603-13.

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