"AC133 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.
- AC133 Antigen
- Antigen, AC133
- CD133 Antigen
- Antigen, CD133
- Prominin 1
- Prominin-Like PROML1
- Prominin Like PROML1
- AC133-1 Antigen
- AC133 1 Antigen
- Antigen, AC133-1
Below are MeSH descriptors whose meaning is more general than "AC133 Antigen".
Below are MeSH descriptors whose meaning is more specific than "AC133 Antigen".
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Below are the most recent publications written about "AC133 Antigen" by people in Profiles.
Das B, Kashino SS, Pulu I, Kalita D, Swami V, Yeger H, Felsher DW, Campos-Neto A. CD271(+) bone marrow mesenchymal stem cells may provide a niche for dormant Mycobacterium tuberculosis. Sci Transl Med. 2013 Jan 30; 5(170):170ra13.
Jiang X, Xing H, Kim TM, Jung Y, Huang W, Yang HW, Song S, Park PJ, Carroll RS, Johnson MD. Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity. Stem Cells. 2012 Jul; 30(7):1313-26.
Knoefel WT, Alexander A, Tustas RY, Schmelzle M, Klein HM, Krieg A, Topp SA, Eisenberger CF, Fuerst G, Schulte am Esch J. [Stem cell-induced liver regeneration]. Zentralbl Chir. 2013 Apr; 138(2):166-72.
Hristov M, Erl W, Weber PC. Endothelial progenitor cells: mobilization, differentiation, and homing. Arterioscler Thromb Vasc Biol. 2003 Jul 01; 23(7):1185-9.