Poly (ADP-Ribose) Polymerase-1

"Poly (ADP-Ribose) Polymerase-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A poly(ADP-ribose) polymerase that contains two ZINC FINGERS in its N-terminal DNA-binding region. It modifies NUCLEAR PROTEINS involved in chromatin architecture and BASE EXCISION REPAIR with POLY ADENOSINE DIPHOSPHATE RIBOSE.

Descriptor ID	D000071137
MeSH Number(s)	D08.811.913.400.725.115.690.420
Concept/Terms	Poly (ADP-Ribose) Polymerase-1 Poly (ADP-Ribose) Polymerase-1 Poly (ADP-Ribose) Synthase-1 PARP1 Protein PARP-1 Protein PARP 1 Protein NAD+ ADP-ribosyltransferase-1 NAD+ ADP ribosyltransferase 1

Below are MeSH descriptors whose meaning is more general than "Poly (ADP-Ribose) Polymerase-1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Glycosyltransferases [D08.811.913.400]
Pentosyltransferases [D08.811.913.400.725]
ADP Ribose Transferases [D08.811.913.400.725.115]
Poly(ADP-ribose) Polymerases [D08.811.913.400.725.115.690]
Poly (ADP-Ribose) Polymerase-1 [D08.811.913.400.725.115.690.420]

Below are MeSH descriptors whose meaning is related to "Poly (ADP-Ribose) Polymerase-1".

Below are MeSH descriptors whose meaning is more specific than "Poly (ADP-Ribose) Polymerase-1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Poly (ADP-Ribose) Polymerase-1" by people in this website by year, and whether "Poly (ADP-Ribose) Polymerase-1" was a major or minor topic of these publications.

Bar chart showing 12 publications over 10 distinct years, with a maximum of 2 publications in 2013 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2007	0	1	1
2013	0	2	2
2015	0	1	1
2016	0	1	1
2018	0	1	1
2019	0	1	1
2020	1	0	1
2024	2	0	2
2025	0	1	1

Below are the most recent publications written about "Poly (ADP-Ribose) Polymerase-1" by people in Profiles.

Whalen JM, Earley J, Wisniewski C, Mercurio AM, Cantor SB. Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability. Nat Cancer. 2025 Feb; 6(2):278-291.

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MacGilvary N, Cantor SB. Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer. DNA Repair (Amst). 2024 Dec; 144:103775.

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Cong K, MacGilvary N, Lee S, MacLeod SG, Calvo J, Peng M, Nedergaard Kousholt A, Day TA, Cantor SB. FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells. Nat Commun. 2024 Mar 23; 15(1):2599.

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Richards R, Schwartz HR, Honeywell ME, Stewart MS, Cruz-Gordillo P, Joyce AJ, Landry BD, Lee MJ. Drug antagonism and single-agent dominance result from differences in death kinetics. Nat Chem Biol. 2020 07; 16(7):791-800.

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Iyer S, Suresh S, Guo D, Daman K, Chen JCJ, Liu P, Zieger M, Luk K, Roscoe BP, Mueller C, King OD, Emerson CP, Wolfe SA. Precise therapeutic gene correction by a simple nuclease-induced double-stranded break. Nature. 2019 04; 568(7753):561-565.

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Kordon MM, Szczurek A, Berniak K, Szelest O, Solarczyk K, Tworzydlo M, Wachsmann-Hogiu S, Vaahtokari A, Cremer C, Pederson T, Dobrucki JW. PML-like subnuclear bodies, containing XRCC1, juxtaposed to DNA replication-based single-strand breaks. FASEB J. 2019 02; 33(2):2301-2313.

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Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A. Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature. 2016 07 21; 535(7612):382-7.

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Jog NR, Caricchio R. 17? estradiol regulates adhesion molecule expression in mesangial cells during glomerulonephritis. Clin Immunol. 2015 Jul; 159(1):13-22.

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Jog NR, Caricchio R. Differential regulation of cell death programs in males and females by Poly (ADP-Ribose) Polymerase-1 and 17? estradiol. Cell Death Dis. 2013 Aug 08; 4:e758.

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Venkateshaiah SU, Khan S, Ling W, Bam R, Li X, van Rhee F, Usmani S, Barlogie B, Epstein J, Yaccoby S. NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity. Exp Hematol. 2013 Jun; 41(6):547-557.e2.

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