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Amit Singhal PhD

TitleAdjunct Associate Professor
InstitutionUMass Chan Medical School
AddressA Biomedical Grove
#05-13 Immunos
Singapore 138648
Phone+656407 0631
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionInfectious Diseases

    Collapse Biography 
    Collapse education and training
    Kurukshetra University, Kurukshetra, HR, IndiaBSBiochemistry
    The National Dairy Research Institute, Karnal, , IndiaMSAnimal Biotechnology
    All India Institute of Medical Sciences, New Delhi, , IndiaPHD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. L?-Bury G, Chen Y, Rhen JM, Grenier JK, Singhal A, Russell DG, Boliar S. HIV-1 active and latent infections induce disparate chromatin reorganization and transcriptional regulation of mRNAs and lncRNAs in SupT1 cells. mBio. 2023 Dec 01; e0261923. PMID: 38038477.
      Citations:    Fields:    
    2. Martinez N, Smulan LJ, Jameson ML, Smith CM, Cavallo K, Bellerose M, Williams J, West K, Sassetti CM, Singhal A, Kornfeld H. Glycerol contributes to tuberculosis susceptibility in male mice with type 2 diabetes. Nat Commun. 2023 09 20; 14(1):5840. PMID: 37730757.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Del Rosario RCH, Poschmann J, Lim C, Cheng CY, Kumar P, Riou C, Ong ST, Gerges S, Hajan HS, Kumar D, Marzuki M, Lu X, Lee A, Wijaya GC, Rayan NA, Zhuang Z, Du Bruyn E, Chee CBE, Lee B, Lum J, Zolezzi F, Poidinger M, Rotzschke O, Khor CC, Wilkinson RJ, Wang YT, Chandy GK, De Libero G, Singhal A, Prabhakar S. Author Correction: Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection. Nat Microbiol. 2022 Nov; 7(11):1943. PMID: 36056160.
      Citations: 1     Fields:    
    4. Del Rosario RCH, Poschmann J, Lim C, Cheng CY, Kumar P, Riou C, Ong ST, Gerges S, Hajan HS, Kumar D, Marzuki M, Lu X, Lee A, Wijaya GC, Rayan NA, Zhuang Z, Du Bruyn E, Chee CBE, Lee B, Lum J, Zolezzi F, Poidinger M, Rotzschke O, Khor CC, Wilkinson RJ, Wang YT, Chandy GK, De Libero G, Singhal A, Prabhakar S. Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection. Nat Microbiol. 2022 02; 7(2):312-326. PMID: 35102304.
      Citations: 3     Fields:    Translation:HumansCells
    5. Miow QH, Vallejo AF, Wang Y, Hong JM, Bai C, Teo FS, Wang AD, Loh HR, Tan TZ, Ding Y, She HW, Gan SH, Paton NI, Lum J, Tay A, Chee CB, Tambyah PA, Polak ME, Wang YT, Singhal A, Elkington PT, Friedland JS, Ong CW. Doxycycline host-directed therapy in human pulmonary tuberculosis. J Clin Invest. 2021 08 02; 131(15). PMID: 34128838.
      Citations: 16     Fields:    Translation:HumansCTClinical Trials
    6. Rouers A, Appanna R, Chevrier M, Lum J, Lau MC, Tan L, Loy T, Tay A, Sethi R, Sathiakumar D, Kaur K, B?hme J, Leo YS, Renia L, Howland SW, Singhal A, Chen J, Fink K. CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function. iScience. 2021 May 21; 24(5):102482. PMID: 34113823.
    7. Smulan LJ, Martinez N, Kiritsy MC, Kativhu C, Cavallo K, Sassetti CM, Singhal A, Remold HG, Kornfeld H. Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death. mBio. 2021 02 02; 12(1). PMID: 33531400.
      Citations: 14     Fields:    Translation:AnimalsCells
    8. Talwar S, Pandey M, Sharma C, Kutum R, Lum J, Carbajo D, Goel R, Poidinger M, Dash D, Singhal A, Pandey AK. Role of VapBC12 Toxin-Antitoxin Locus in Cholesterol-Induced Mycobacterial Persistence. mSystems. 2020 Dec 15; 5(6). PMID: 33323416.
      Citations: 7     Fields:    
    9. B?hme J, Martinez N, Li S, Lee A, Marzuki M, Tizazu AM, Ackart D, Frenkel JH, Todd A, Lachmandas E, Lum J, Shihui F, Ng TP, Lee B, Larbi A, Netea MG, Basaraba R, van Crevel R, Newell E, Kornfeld H, Singhal A. Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits. Nat Commun. 2020 10 16; 11(1):5225. PMID: 33067434.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    10. Kumar D, Lee B, Puan KJ, Lee W, Luis BS, Yusof N, Andiappan AK, Del Rosario R, Poschmann J, Kumar P, DeLibero G, Singhal A, Prabhakar S, De Yun W, Poidinger M, R?tzschke O. Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation. Sci Rep. 2019 10 23; 9(1):15245. PMID: 31645609.
      Citations: 8     Fields:    Translation:HumansCells
    11. Martinez N, Cheng CY, Ketheesan N, Cullen A, Tang Y, Lum J, West K, Poidinger M, Guertin DA, Singhal A, Kornfeld H. mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis. EBioMedicine. 2019 Jul; 45:314-327. PMID: 31279779.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    12. Magee MJ, Salindri AD, Kornfeld H, Singhal A. Reduced prevalence of latent tuberculosis infection in diabetes patients using metformin and statins. Eur Respir J. 2019 03; 53(3). PMID: 30523163.
      Citations: 18     Fields:    Translation:Humans
    13. Singhal A, Cheng CY. Host NAD+ metabolism and infections: therapeutic implications. Int Immunol. 2019 02 15; 31(2):59-67. PMID: 30329059.
      Citations: 14     Fields:    Translation:HumansAnimals
    14. Kornfeld H, Singhal A. Enlisting the Host to Fight TB. Chest. 2018 06; 153(6):1292-1293. PMID: 29884247.
      Citations: 1     Fields:    Translation:Humans
    15. Shakespear MR, Iyer A, Cheng CY, Das Gupta K, Singhal A, Fairlie DP, Sweet MJ. Lysine Deacetylases and Regulated Glycolysis in Macrophages. Trends Immunol. 2018 06; 39(6):473-488. PMID: 29567326.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    16. Cheng CY, B?hme J, Singhal A. Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis. J Leukoc Biol. 2018 02; 103(2):215-223. PMID: 28951420.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    17. Vacca M, B?hme J, Zambetti LP, Khameneh HJ, Paleja BS, Laudisi F, Ho AWS, Neo K, Leong KWK, Marzuki M, Lee B, Poidinger M, Santambrogio L, Tsenova L, Zolezzi F, De Libero G, Singhal A, Mortellaro A. NLRP10 Enhances CD4+ T-Cell-Mediated IFN? Response via Regulation of Dendritic Cell-Derived IL-12 Release. Front Immunol. 2017; 8:1462. PMID: 29163529.
      Citations: 12     Fields:    
    18. Cheng CY, Gutierrez NM, Marzuki MB, Lu X, Foreman TW, Paleja B, Lee B, Balachander A, Chen J, Tsenova L, Kurepina N, Teng KWW, West K, Mehra S, Zolezzi F, Poidinger M, Kreiswirth B, Kaushal D, Kornfeld H, Newell EW, Singhal A. Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis. Sci Immunol. 2017 Mar; 2(9). PMID: 28707004.
      Citations: 66     Fields:    
    19. Narang V, Ramli MA, Singhal A, Kumar P, de Libero G, Poidinger M, Monterola C. Automated Identification of Core Regulatory Genes in Human Gene Regulatory Networks. PLoS Comput Biol. 2015; 11(9):e1004504. PMID: 26393364.
      Citations: 17     Fields:    Translation:HumansCells
    20. Singhal A, Jie L, Kumar P, Hong GS, Leow MK, Paleja B, Tsenova L, Kurepina N, Chen J, Zolezzi F, Kreiswirth B, Poidinger M, Chee C, Kaplan G, Wang YT, De Libero G. Metformin as adjunct antituberculosis therapy. Sci Transl Med. 2014 Nov 19; 6(263):263ra159. PMID: 25411472.
      Citations: 224     Fields:    Translation:HumansCells
    21. Lepore M, Kalinichenko A, Kalinicenko A, Colone A, Paleja B, Singhal A, Tschumi A, Lee B, Poidinger M, Zolezzi F, Quagliata L, Sander P, Newell E, Bertoletti A, Terracciano L, De Libero G, Mori L. Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCR? repertoire. Nat Commun. 2014 May 15; 5:3866. PMID: 24832684.
      Citations: 176     Fields:    Translation:HumansCells
    22. Singhal A, Mathys V, Kiass M, Creusy C, Delaire B, Aliouat el M, Dartois V, Kaplan G, Bifani P. BCG induces protection against Mycobacterium tuberculosis infection in the Wistar rat model. PLoS One. 2011; 6(12):e28082. PMID: 22162757.
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