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Amit Singhal PhD

TitleAdjunct Associate Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressA Biomedical Grove
#05-13 Immunos
Singapore 138648
Phone+656407 0631
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionPulmonary Medicine


    Collapse Biography 
    Collapse education and training
    Kurukshetra University, Kurukshetra, HR, IndiaBSBiochemistry
    The National Dairy Research Institute, Karnal, , IndiaMSAnimal Biotechnology
    All India Institute of Medical Sciences, New Delhi, , IndiaPHD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Giri S, Ingawale S, Khatana G, Gore P, Praharaj DL, Wong VW, Huang DQ, Singhal A, Choudhury A. Metabolic Cause of Cirrhosis Is the Emerging Etiology for Primary Liver Cancer in the Asia-Oceania Region: Analysis of Global Burden of Disease (GBD) Study 2021. J Gastroenterol Hepatol. 2025 May; 40(5):1188-1201. PMID: 40016821.
      Citations:    
    2. Sweet MJ, Ramnath D, Singhal A, Kapetanovic R. Inducible antibacterial responses in macrophages. Nat Rev Immunol. 2025 Feb; 25(2):92-107. PMID: 39294278.
      Citations:    
    3. Celhar T, Li X, Zhao Y, Tay HC, Lee A, Liew HH, Shepherdson EK, Rajarethinam R, Fan Y, Mak A, Chan JKY, Singhal A, Takahashi T. Fetal liver CD34+ contain human immune and endothelial progenitors and mediate solid tumor rejection in NOG mice. Stem Cell Res Ther. 2024 06 09; 15(1):164. PMID: 38853275.
      Citations:    
    4. Lin QXX, Rajagopalan D, Gamage AM, Tan LM, Venkatesh PN, Chan WOY, Kumar D, Agrawal R, Chen Y, Fong SW, Singh A, Sun LJ, Tan SY, Chai LYA, Somani J, Lee B, Renia L, Ng LFP, Ramanathan K, Wang LF, Young B, Lye D, Singhal A, Prabhakar S. Longitudinal single cell atlas identifies complex temporal relationship between type I interferon response and COVID-19 severity. Nat Commun. 2024 Jan 18; 15(1):567. PMID: 38238298.
      Citations:    
    5. Verma S, Das M, Sharma RD, Yadav V, Thakur S, Sharma P, Marzuki M, Foo S, Piperno GM, Khan MZ, Mathew B, Bajpai M, Maras JS, Howland S, Sarkar S, Benvenuti F, Singh A, Nandicoori V, Singhal A, Kumar D. A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis. bioRxiv. 2023 Dec 01. PMID: 38076943.
      Citations:    
    6. L?-Bury G, Chen Y, Rhen JM, Grenier JK, Singhal A, Russell DG, Boliar S. HIV-1 active and latent infections induce disparate chromatin reorganization and transcriptional regulation of mRNAs and lncRNAs in SupT1 cells. mBio. 2023 Dec 19; 14(6):e0261923. PMID: 38038477.
      Citations:    Fields:    
    7. Martinez N, Smulan LJ, Jameson ML, Smith CM, Cavallo K, Bellerose M, Williams J, West K, Sassetti CM, Singhal A, Kornfeld H. Glycerol contributes to tuberculosis susceptibility in male mice with type 2 diabetes. Nat Commun. 2023 09 20; 14(1):5840. PMID: 37730757.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Del Rosario RCH, Poschmann J, Lim C, Cheng CY, Kumar P, Riou C, Ong ST, Gerges S, Hajan HS, Kumar D, Marzuki M, Lu X, Lee A, Wijaya GC, Rayan NA, Zhuang Z, Du Bruyn E, Chee CBE, Lee B, Lum J, Zolezzi F, Poidinger M, Rotzschke O, Khor CC, Wilkinson RJ, Wang YT, Chandy GK, De Libero G, Singhal A, Prabhakar S. Author Correction: Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection. Nat Microbiol. 2022 Nov; 7(11):1943. PMID: 36056160.
      Citations: 1     Fields:    
    9. Chaudhary D, Singh A, Marzuki M, Ghosh A, Kidwai S, Gosain TP, Chawla K, Gupta SK, Agarwal N, Saha S, Kumar Y, Thakur KG, Singhal A, Singh R. Identification of small molecules targeting homoserine acetyl transferase from Mycobacterium tuberculosis and Staphylococcus aureus. Sci Rep. 2022 08 13; 12(1):13801. PMID: 35963878.
      Citations:    
    10. Del Rosario RCH, Poschmann J, Lim C, Cheng CY, Kumar P, Riou C, Ong ST, Gerges S, Hajan HS, Kumar D, Marzuki M, Lu X, Lee A, Wijaya GC, Rayan NA, Zhuang Z, Du Bruyn E, Chee CBE, Lee B, Lum J, Zolezzi F, Poidinger M, Rotzschke O, Khor CC, Wilkinson RJ, Wang YT, Chandy GK, De Libero G, Singhal A, Prabhakar S. Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection. Nat Microbiol. 2022 02; 7(2):312-326. PMID: 35102304.
      Citations: 3     Fields:    Translation:HumansCells
    11. Cai Y, Wang Y, Shi C, Dai Y, Li F, Xu Y, Zhang P, Kong F, Deng G, Wen Z, Zhou Q, Kang BC, Singhal A, Yang Q, Feng CG, Chen X. Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion. J Exp Med. 2022 03 07; 219(3). PMID: 35061012.
      Citations:    
    12. Reales-Calderon JA, Tso GHW, Tan ASM, Hor PX, B?hme J, Teng KWW, Newell EW, Singhal A, Pavelka N. Gut-Evolved Candida albicans Induces Metabolic Changes in Neutrophils. Front Cell Infect Microbiol. 2021; 11:743735. PMID: 34881192.
      Citations:    
    13. Miow QH, Vallejo AF, Wang Y, Hong JM, Bai C, Teo FS, Wang AD, Loh HR, Tan TZ, Ding Y, She HW, Gan SH, Paton NI, Lum J, Tay A, Chee CB, Tambyah PA, Polak ME, Wang YT, Singhal A, Elkington PT, Friedland JS, Ong CW. Doxycycline host-directed therapy in human pulmonary tuberculosis. J Clin Invest. 2021 08 02; 131(15). PMID: 34128838.
      Citations: 16     Fields:    Translation:HumansCTClinical Trials
    14. Pisu D, Huang L, Narang V, Theriault M, L?-Bury G, Lee B, Lakudzala AE, Mzinza DT, Mhango DV, Mitini-Nkhoma SC, Jambo KC, Singhal A, Mwandumba HC, Russell DG. Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung. J Exp Med. 2021 09 06; 218(9). PMID: 34292313.
      Citations:    
    15. Rouers A, Chng MHY, Lee B, Rajapakse MP, Kaur K, Toh YX, Sathiakumar D, Loy T, Thein TL, Lim VWX, Singhal A, Yeo TW, Leo YS, Vora KA, Casimiro D, Lim B, Tucker-Kellogg L, Rivino L, Newell EW, Fink K. Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection. Cell Rep Med. 2021 05 18; 2(5):100278. PMID: 34095880.
      Citations:    
    16. Rouers A, Appanna R, Chevrier M, Lum J, Lau MC, Tan L, Loy T, Tay A, Sethi R, Sathiakumar D, Kaur K, B?hme J, Leo YS, Renia L, Howland SW, Singhal A, Chen J, Fink K. CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function. iScience. 2021 May 21; 24(5):102482. PMID: 34113823.
      Citations:    
    17. Smulan LJ, Martinez N, Kiritsy MC, Kativhu C, Cavallo K, Sassetti CM, Singhal A, Remold HG, Kornfeld H. Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death. mBio. 2021 02 02; 12(1). PMID: 33531400.
      Citations: 14     Fields:    Translation:AnimalsCells
    18. Talwar S, Pandey M, Sharma C, Kutum R, Lum J, Carbajo D, Goel R, Poidinger M, Dash D, Singhal A, Pandey AK. Role of VapBC12 Toxin-Antitoxin Locus in Cholesterol-Induced Mycobacterial Persistence. mSystems. 2020 Dec 15; 5(6). PMID: 33323416.
      Citations: 7     Fields:    
    19. Agrawal R, Testi I, Rousselot A, Chen EJ, Lakshminarayanan R, Singhal A, Bundele M, Hutchison P, Kon OM, Gupta V, Pavesio C. Insights into the molecular pathogenesis of ocular tuberculosis. Tuberculosis (Edinb). 2021 01; 126:102018. PMID: 33202350.
      Citations:    
    20. B?hme J, Martinez N, Li S, Lee A, Marzuki M, Tizazu AM, Ackart D, Frenkel JH, Todd A, Lachmandas E, Lum J, Shihui F, Ng TP, Lee B, Larbi A, Netea MG, Basaraba R, van Crevel R, Newell E, Kornfeld H, Singhal A. Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits. Nat Commun. 2020 10 16; 11(1):5225. PMID: 33067434.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    21. Hussain S, Anees A, Das A, Nguyen BP, Marzuki M, Lin S, Wright G, Singhal A. High-content image generation for drug discovery using generative adversarial networks. Neural Netw. 2020 Dec; 132:353-363. PMID: 32977280.
      Citations:    
    22. Kumar D, Lee B, Puan KJ, Lee W, Luis BS, Yusof N, Andiappan AK, Del Rosario R, Poschmann J, Kumar P, DeLibero G, Singhal A, Prabhakar S, De Yun W, Poidinger M, R?tzschke O. Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation. Sci Rep. 2019 10 23; 9(1):15245. PMID: 31645609.
      Citations: 8     Fields:    Translation:HumansCells
    23. Martinez N, Cheng CY, Ketheesan N, Cullen A, Tang Y, Lum J, West K, Poidinger M, Guertin DA, Singhal A, Kornfeld H. mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis. EBioMedicine. 2019 Jul; 45:314-327. PMID: 31279779.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    24. Lachmandas E, Eckold C, B?hme J, Koeken VACM, Marzuki MB, Blok B, Arts RJW, Chen J, Teng KWW, Ratter J, Smolders EJ, Van den Heuvel C, Stienstra R, Dockrell HM, Newell E, Netea MG, Singhal A, Cliff JM, Van Crevel R. Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects. J Infect Dis. 2019 06 05; 220(1):139-150. PMID: 30753544.
      Citations:    
    25. Magee MJ, Salindri AD, Kornfeld H, Singhal A. Reduced prevalence of latent tuberculosis infection in diabetes patients using metformin and statins. Eur Respir J. 2019 03; 53(3). PMID: 30523163.
      Citations: 18     Fields:    Translation:Humans
    26. Singhal A, Cheng CY. Host NAD+ metabolism and infections: therapeutic implications. Int Immunol. 2019 02 15; 31(2):59-67. PMID: 30329059.
      Citations: 14     Fields:    Translation:HumansAnimals
    27. Kornfeld H, Singhal A. Enlisting the Host to Fight TB. Chest. 2018 06; 153(6):1292-1293. PMID: 29884247.
      Citations: 1     Fields:    Translation:Humans
    28. Shakespear MR, Iyer A, Cheng CY, Das Gupta K, Singhal A, Fairlie DP, Sweet MJ. Lysine Deacetylases and Regulated Glycolysis in Macrophages. Trends Immunol. 2018 06; 39(6):473-488. PMID: 29567326.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    29. Cheng CY, B?hme J, Singhal A. Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis. J Leukoc Biol. 2018 02; 103(2):215-223. PMID: 28951420.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    30. Vacca M, B?hme J, Zambetti LP, Khameneh HJ, Paleja BS, Laudisi F, Ho AWS, Neo K, Leong KWK, Marzuki M, Lee B, Poidinger M, Santambrogio L, Tsenova L, Zolezzi F, De Libero G, Singhal A, Mortellaro A. NLRP10 Enhances CD4+ T-Cell-Mediated IFN? Response via Regulation of Dendritic Cell-Derived IL-12 Release. Front Immunol. 2017; 8:1462. PMID: 29163529.
      Citations: 12     Fields:    
    31. Cheng CY, Gutierrez NM, Marzuki MB, Lu X, Foreman TW, Paleja B, Lee B, Balachander A, Chen J, Tsenova L, Kurepina N, Teng KWW, West K, Mehra S, Zolezzi F, Poidinger M, Kreiswirth B, Kaushal D, Kornfeld H, Newell EW, Singhal A. Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis. Sci Immunol. 2017 Mar; 2(9). PMID: 28707004.
      Citations: 66     Fields:    
    32. Mani V, Paleja B, Larbi K, Kumar P, Tay JA, Siew JY, Inci F, Wang S, Chee C, Wang YT, Demirci U, De Libero G, Singhal A. Microchip-based ultrafast serodiagnostic assay for tuberculosis. Sci Rep. 2016 10 24; 6:35845. PMID: 27775039.
      Citations:    
    33. Yang C, Krishnamurthy S, Liu J, Liu S, Lu X, Coady DJ, Cheng W, De Libero G, Singhal A, Hedrick JL, Yang YY. Broad-Spectrum Antimicrobial Star Polycarbonates Functionalized with Mannose for Targeting Bacteria Residing inside Immune Cells. Adv Healthc Mater. 2016 06; 5(11):1272-81. PMID: 27028263.
      Citations:    
    34. Narang V, Ramli MA, Singhal A, Kumar P, de Libero G, Poidinger M, Monterola C. Automated Identification of Core Regulatory Genes in Human Gene Regulatory Networks. PLoS Comput Biol. 2015; 11(9):e1004504. PMID: 26393364.
      Citations: 17     Fields:    Translation:HumansCells
    35. Haver HL, Chua A, Ghode P, Lakshminarayana SB, Singhal A, Mathema B, Wintjens R, Bifani P. Mutations in genes for the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro-selected PA-824-resistant mutants of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2015 Sep; 59(9):5316-23. PMID: 26100695.
      Citations:    
    36. Singhal A, Jie L, Kumar P, Hong GS, Leow MK, Paleja B, Tsenova L, Kurepina N, Chen J, Zolezzi F, Kreiswirth B, Poidinger M, Chee C, Kaplan G, Wang YT, De Libero G. Metformin as adjunct antituberculosis therapy. Sci Transl Med. 2014 Nov 19; 6(263):263ra159. PMID: 25411472.
      Citations: 224     Fields:    Translation:HumansCells
    37. De Libero G, Singhal A, Lepore M, Mori L. Nonclassical T cells and their antigens in tuberculosis. Cold Spring Harb Perspect Med. 2014 Jul 24; 4(9):a018473. PMID: 25059739.
      Citations:    
    38. Mani V, Wang S, Inci F, De Libero G, Singhal A, Demirci U. Emerging technologies for monitoring drug-resistant tuberculosis at the point-of-care. Adv Drug Deliv Rev. 2014 Nov 30; 78:105-17. PMID: 24882226.
      Citations:    
    39. Lepore M, Kalinichenko A, Kalinicenko A, Colone A, Paleja B, Singhal A, Tschumi A, Lee B, Poidinger M, Zolezzi F, Quagliata L, Sander P, Newell E, Bertoletti A, Terracciano L, De Libero G, Mori L. Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCR? repertoire. Nat Commun. 2014 May 15; 5:3866. PMID: 24832684.
      Citations: 176     Fields:    Translation:HumansCells
    40. Singhal A, Mori L, De Libero G. T cell recognition of non-peptidic antigens in infectious diseases. Indian J Med Res. 2013 Nov; 138(5):620-31. PMID: 24434317.
      Citations:    
    41. Wang S, Inci F, De Libero G, Singhal A, Demirci U. Point-of-care assays for tuberculosis: role of nanotechnology/microfluidics. Biotechnol Adv. 2013 Jul-Aug; 31(4):438-49. PMID: 23357365.
      Citations:    
    42. Facciotti F, Ramanjaneyulu GS, Lepore M, Sansano S, Cavallari M, Kistowska M, Forss-Petter S, Ni G, Colone A, Singhal A, Berger J, Xia C, Mori L, De Libero G. Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus. Nat Immunol. 2012 Mar 18; 13(5):474-80. PMID: 22426352.
      Citations:    
    43. Singhal A, Mathys V, Kiass M, Creusy C, Delaire B, Aliouat el M, Dartois V, Kaplan G, Bifani P. BCG induces protection against Mycobacterium tuberculosis infection in the Wistar rat model. PLoS One. 2011; 6(12):e28082. PMID: 22162757.
      Citations:    
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