Metformin

"Metformin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)

Descriptor ID	D008687
MeSH Number(s)	D02.078.370.141.450
Concept/Terms	Metformin Metformin Dimethylbiguanidine Dimethylguanylguanidine Glucophage Glucophage Metformin Hydrochloride Metformin Hydrochloride Hydrochloride, Metformin Metformin HCl HCl, Metformin

Below are MeSH descriptors whose meaning is more general than "Metformin".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Amidines [D02.078]
Guanidines [D02.078.370]
Biguanides [D02.078.370.141]
Metformin [D02.078.370.141.450]

Below are MeSH descriptors whose meaning is related to "Metformin".

Below are MeSH descriptors whose meaning is more specific than "Metformin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Metformin" by people in this website by year, and whether "Metformin" was a major or minor topic of these publications.

Bar chart showing 58 publications over 22 distinct years, with a maximum of 6 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	1	2
2003	0	1	1
2005	1	0	1
2006	1	1	2
2008	1	0	1
2009	2	0	2
2010	3	1	4
2011	1	0	1
2012	0	1	1
2013	2	1	3
2014	3	1	4
2015	1	3	4
2016	1	0	1
2017	1	2	3
2018	3	2	5
2019	5	1	6
2020	1	0	1
2021	3	1	4
2022	2	0	2
2023	3	0	3
2024	1	1	2
2025	5	0	5

Below are the most recent publications written about "Metformin" by people in Profiles.

Cashman TJ, Saheera S, Blau AE, Mensah Otabil E, Nagy NY, Samenuk TD, Fitzgibbons TP, McManus DD, Trivedi CM. Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin. JCI Insight. 2025 Sep 09; 10(17).

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Bramante CT, Stewart TG, Boulware DR, McCarthy MW, Gao Y, Rothman RL, Mourad A, Thicklin F, Cohen JB, Garcia Del Sol IT, Ruiz-Unger J, Shah NS, Mehta M, Cardona OQ, Scott J, Ginde AA, Castro M, Jayaweera D, Sulkowski M, Gentile N, McTigue K, Felker GM, Collins S, Dunsmore SE, Adam SJ, Lindsell CJ, Hernandez AF, Naggie S. Metformin and Time to Sustained Recovery in Adults With COVID-19: The ACTIV-6 Randomized Clinical Trial. JAMA Intern Med. 2025 Sep 01; 185(9):1092-1101.

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Arian CM, O'Mahony ET, Manwill PK, Graf TN, Oberlies NH, Cech NB, Clarke JD, Smith JG, Paine MF, Kelly EJ, Thummel KE. A gut response: Application of human enteroid monolayers to probe the mechanism of the goldenseal-mediated inhibition of metformin intestinal absorption. J Pharmacol Exp Ther. 2025 Jun; 392(6):103597.

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Hasanvand A, Ghandinezhad M, Nourmohammadi M, Hatami F, Beiranvand B, Haghighatian Z, Amanolahi Baharvand P, Kharazmkia A. Investigating the role of the AMPK signaling pathway in preventing CCI-induced neuropathy in rats: focus on anti-inflammatory effects. Neurol Res. 2025 Jun; 47(6):494-503.

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Wilkie G, Payne A, Baltich Nelson B, Whelan AR. Early gestational diabetes mellitus and the effect of metformin use on perinatal outcomes: a systematic review. Minerva Obstet Gynecol. 2025 Jun; 77(3):215-218.

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Sawalha K, Gautam N, Sivakumar K, Paydak H, Mehta JL. Metformin: Its salutary effects beyond diabetes mellitus. J Investig Med. 2025 Jun; 73(5):363-375.

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Chen F, Mangano KM, Garelnabi M, Cardaleen K, Tucker KL. Associations among diabetes medication use, serum magnesium, and insulin resistance in a cohort of older Puerto Rican adults. Am J Clin Nutr. 2024 06; 119(6):1523-1532.

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Lee J, Xue X, Au E, McIntyre WB, Asgariroozbehani R, Panganiban K, Tseng GC, Papoulias M, Smith E, Monteiro J, Shah D, Maksyutynska K, Cavalier S, Radoncic E, Prasad F, Agarwal SM, Mccullumsmith R, Freyberg Z, Logan RW, Hahn MK. Glucose dysregulation in antipsychotic-naive first-episode psychosis: in silico exploration of gene expression signatures. Transl Psychiatry. 2024 Jan 10; 14(1):19.

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Yusim D, Tiru B, Abdullin M, Landry DL, Hodgins S, Braden GL. Treatment of severe metformin-associated lactic acidosis with renal replacement therapy and tris-hydroxymethyl aminomethane: a case report. J Med Case Rep. 2023 Oct 20; 17(1):462.

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Cedillo L, Ahsan FM, Li S, Stuhr NL, Zhou Y, Zhang Y, Adedoja A, Murphy LM, Yerevanian A, Emans S, Dao K, Li Z, Peterson ND, Watrous J, Jain M, Das S, Pukkila-Worley R, Curran SP, Soukas AA. Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans. Elife. 2023 08 22; 12.

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