Metformin

"Metformin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)

Descriptor ID	D008687
MeSH Number(s)	D02.078.370.141.450
Concept/Terms	Metformin Metformin Dimethylbiguanidine Dimethylguanylguanidine Glucophage Glucophage Metformin Hydrochloride Metformin Hydrochloride Hydrochloride, Metformin Metformin HCl HCl, Metformin

Below are MeSH descriptors whose meaning is more general than "Metformin".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Amidines [D02.078]
Guanidines [D02.078.370]
Biguanides [D02.078.370.141]
Metformin [D02.078.370.141.450]

Below are MeSH descriptors whose meaning is related to "Metformin".

Below are MeSH descriptors whose meaning is more specific than "Metformin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Metformin" by people in this website by year, and whether "Metformin" was a major or minor topic of these publications.

Bar chart showing 52 publications over 22 distinct years, with a maximum of 5 publications in 2018 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	1	2
2003	0	1	1
2005	1	0	1
2006	1	1	2
2008	1	0	1
2009	2	0	2
2010	3	1	4
2011	1	0	1
2012	0	1	1
2013	2	1	3
2014	3	1	4
2015	1	3	4
2016	1	0	1
2017	1	2	3
2018	3	2	5
2019	4	1	5
2020	1	0	1
2021	2	1	3
2022	2	0	2
2023	3	0	3
2024	1	1	2
2025	1	0	1

Below are the most recent publications written about "Metformin" by people in Profiles.

Hasanvand A, Ghandinezhad M, Nourmohammadi M, Hatami F, Beiranvand B, Haghighatian Z, Amanolahi Baharvand P, Kharazmkia A. Investigating the role of the AMPK signaling pathway in preventing CCI-induced neuropathy in rats: focus on anti-inflammatory effects. Neurol Res. 2025 Jun; 47(6):494-503.

View in: PubMed
Sawalha K, Gautam N, Sivakumar K, Paydak H, Mehta JL. Metformin: Its salutary effects beyond diabetes mellitus. J Investig Med. 2025 Jun; 73(5):363-375.

View in: PubMed
Chen F, Mangano KM, Garelnabi M, Cardaleen K, Tucker KL. Associations among diabetes medication use, serum magnesium, and insulin resistance in a cohort of older Puerto Rican adults. Am J Clin Nutr. 2024 06; 119(6):1523-1532.

View in: PubMed
Lee J, Xue X, Au E, McIntyre WB, Asgariroozbehani R, Panganiban K, Tseng GC, Papoulias M, Smith E, Monteiro J, Shah D, Maksyutynska K, Cavalier S, Radoncic E, Prasad F, Agarwal SM, Mccullumsmith R, Freyberg Z, Logan RW, Hahn MK. Glucose dysregulation in antipsychotic-naive first-episode psychosis: in silico exploration of gene expression signatures. Transl Psychiatry. 2024 Jan 10; 14(1):19.

View in: PubMed
Yusim D, Tiru B, Abdullin M, Landry DL, Hodgins S, Braden GL. Treatment of severe metformin-associated lactic acidosis with renal replacement therapy and tris-hydroxymethyl aminomethane: a case report. J Med Case Rep. 2023 Oct 20; 17(1):462.

View in: PubMed
Cedillo L, Ahsan FM, Li S, Stuhr NL, Zhou Y, Zhang Y, Adedoja A, Murphy LM, Yerevanian A, Emans S, Dao K, Li Z, Peterson ND, Watrous J, Jain M, Das S, Pukkila-Worley R, Curran SP, Soukas AA. Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans. Elife. 2023 08 22; 12.

View in: PubMed
Lopez-Candales A, Monte S, Sawalha K, Norgard NB. Time to revisit the true role of metformin in type 2 diabetes mellitus. Postgrad Med. 2023 08; 135(6):539-542.

View in: PubMed
Dinesh D, Lee JS, Scott TM, Tucker KL, Palacios N. Association between Acid-Lowering Agents, Metformin, and Vitamin B12 among Boston-Area Puerto Ricans. J Nutr. 2023 08; 153(8):2380-2388.

View in: PubMed
Frakes MA, McWade J, Ender V, Cohen JE, Wilcox SR. Ventilator Management in Metformin-Associated Lactic Acidosis: A Case Report. Air Med J. 2023 Jul-Aug; 42(4):300-302.

View in: PubMed
Crist M, Yaniv B, Palackdharry S, Lehn MA, Medvedovic M, Stone T, Gulati S, Karivedu V, Borchers M, Fuhrman B, Crago A, Curry J, Martinez-Outschoorn U, Takiar V, Wise-Draper TM. Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition. J Immunother Cancer. 2022 11; 10(11).

View in: PubMed

People

Explore

Similar Concepts

Top Journals