Header Logo

Richard Gregory PhD

TitleChair and Professor
Endowed TitleEleanor Eustis Farrington Chair in Cancer Research
InstitutionUMass Chan Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program


    Collapse Biography 
    Collapse education and training
    University of Liverpool, Liverpool, , United KingdomBSGenetics
    University of Cambridge, Cambridge, , United KingdomPHDGenomic Imprinting

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ramirez-Moya J, Antika TR, Liu Q, Xiong X, Ali R, Gutierrez A, Gregory RI. The tRNA Editing Complex ADAT2/3 Promotes Cancer Cell Growth and Codon-biased mRNA Translation. J Mol Biol. 2025 Nov 01; 437(21):169414. PMID: 40907939.
      Citations:    
    2. Ali RH, Orellana EA, Lee SH, Chae YC, Chen Y, Clauwaert J, Kennedy AL, Gutierrez AE, Papke DJ, Valenzuela M, Silverman B, Falzetta A, Ficarro SB, Marto JA, Fletcher CDM, Perez-Atayde A, Alcindor T, Shimamura A, Prensner JR, Gregory RI, Gutierrez A. A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation. Mol Cell. 2025 Mar 06; 85(5):948-961.e11. PMID: 39892392.
      Citations:    
    3. Kahraman S, De Jesus DF, Wei J, Brown NK, Zou Z, Hu J, Pirouz M, Gregory RI, He C, Kulkarni RN. m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation. EMBO J. 2024 Nov; 43(22):5445-5468. PMID: 39322760.
      Citations:    
    4. Cui J, Sendinc E, Liu Q, Kim S, Fang JY, Gregory RI. m3C32 tRNA modification controls serine codon-biased mRNA translation, cell cycle, and DNA-damage response. Nat Commun. 2024 Jul 10; 15(1):5775. PMID: 38982125.
      Citations:    
    5. Orellana EA, Siegal E, Gregory RI. tRNA dysregulation and disease. Nat Rev Genet. 2022 11; 23(11):651-664. PMID: 35681060.
      Citations:    
    6. Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI. METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation. Mol Cell. 2021 08 19; 81(16):3323-3338.e14. PMID: 34352207.
      Citations:    
    7. Xiong X, Hou L, Park YP, Molinie B, Gregory RI, Kellis M. Genetic drivers of m6A methylation in human brain, lung, heart and muscle. Nat Genet. 2021 08; 53(8):1156-1165. PMID: 34211177.
      Citations:    
    8. Yan B, Freiwald T, Chauss D, Wang L, West E, Mirabelli C, Zhang CJ, Nichols EM, Malik N, Gregory R, Bantscheff M, Ghidelli-Disse S, Kolev M, Frum T, Spence JR, Sexton JZ, Alysandratos KD, Kotton DN, Pittaluga S, Bibby J, Niyonzima N, Olson MR, Kordasti S, Portilla D, Wobus CE, Laurence A, Lionakis MS, Kemper C, Afzali B, Kazemian M. SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation. Sci Immunol. 2021 04 07; 6(58). PMID: 33827897.
      Citations:    
    9. Mapperley C, van de Lagemaat LN, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J, Sarapuu A, Choe J, Ivanova I, Krause DS, von Kriegsheim A, Much C, Morgan M, Gregory RI, Mead AJ, O'Carroll D, Kranc KR. The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function. J Exp Med. 2021 03 01; 218(3). PMID: 33156926.
      Citations:    
    10. Taylor AM, Macari ER, Chan IT, Blair MC, Doulatov S, Vo LT, Raiser DM, Siva K, Basak A, Pirouz M, Shah AN, McGrath K, Humphries JM, Stillman E, Alter BP, Calo E, Gregory RI, Sankaran VG, Flygare J, Ebert BL, Zhou Y, Daley GQ, Zon LI. Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Sci Transl Med. 2020 10 21; 12(566). PMID: 33087503.
      Citations:    
    11. Foster DJ, Chang HM, Haswell JR, Gregory RI, Slack FJ. TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs. Cell Cycle. 2020 09; 19(18):2314-2326. PMID: 32816599.
      Citations:    
    12. Chen H, Gu L, Orellana EA, Wang Y, Guo J, Liu Q, Wang L, Shen Z, Wu H, Gregory RI, Xing Y, Shi Y. METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing. Cell Res. 2020 06; 30(6):544-547. PMID: 31913360.
      Citations:    
    13. Alfaifi AA, Lin WS, Aldhaian BA, Levon JA, Gregory RL. Impact of caffeine on metabolic activity and biofilm formation of Candida albicans on acrylic denture resin in the presence of nicotine. J Prosthet Dent. 2020 Jun; 123(6):875-879. PMID: 31703923.
      Citations:    
    14. Floyd JS, Bloch KM, Brody JA, Maroteau C, Siddiqui MK, Gregory R, Carr DF, Molokhia M, Liu X, Bis JC, Ahmed A, Liu X, Hallberg P, Yue QY, Magnusson PKE, Brisson D, Wiggins KL, Morrison AC, Khoury E, McKeigue P, Stricker BH, Lapeyre-Mestre M, Heckbert SR, Gallagher AM, Chinoy H, Gibbs RA, Bondon-Guitton E, Tracy R, Boerwinkle E, Gaudet D, Conforti A, van Staa T, Sitlani CM, Rice KM, Maitland-van der Zee AH, Wadelius M, Morris AP, Pirmohamed M, Palmer CAN, Psaty BM, Alfirevic A. Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing. PLoS One. 2019; 14(6):e0218115. PMID: 31242253.
      Citations:    
    15. Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, Vukovic M, Allen L, Sarapuu A, Tavosanis A, Guitart AV, Villacreces A, Much C, Choe J, Azar A, van de Lagemaat LN, Vernimmen D, Nehme A, Mazurier F, Somervaille TCP, Gregory RI, O'Carroll D, Kranc KR. Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell. 2019 07 03; 25(1):137-148.e6. PMID: 31031138.
      Citations:    
    16. Hinze L, Pfirrmann M, Karim S, Degar J, McGuckin C, Vinjamur D, Sacher J, Stevenson KE, Neuberg DS, Orellana E, Stanulla M, Gregory RI, Bauer DE, Wagner FF, Stegmaier K, Gutierrez A. Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 2019 04 15; 35(4):664-676.e7. PMID: 30991026.
      Citations:    
    17. Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 09; 561(7724):556-560. PMID: 30232453.
      Citations:    
    18. Og?rek B, Lam HC, Khabibullin D, Liu HJ, Nijmeh J, Triboulet R, Kwiatkowski DJ, Gregory RI, Henske EP. TSC2 regulates microRNA biogenesis via mTORC1 and GSK3?. Hum Mol Genet. 2018 05 01; 27(9):1654-1663. PMID: 29509898.
      Citations:    
    19. Herzog CR, Berzins DW, DenBesten P, Gregory RL, Hargreaves KM, Messer RLW, Mina M, Mooney MP, Paine ML, Phillips C, Presland RB, Quivey RG, Scannapieco FA, Sheridan JF, Svoboda KKH, Trackman PC, Walker MP, Walker SG, Wang CY, Hu JCC. Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016. J Dent Res. 2018 05; 97(5):483-491. PMID: 29328868.
      Citations:    
    20. Tyler DS, Vappiani J, Ca?eque T, Lam EYN, Ward A, Gilan O, Chan YC, Hienzsch A, Rutkowska A, Werner T, Wagner AJ, Lugo D, Gregory R, Ramirez Molina C, Garton N, Wellaway CR, Jackson S, MacPherson L, Figueiredo M, Stolzenburg S, Bell CC, House C, Dawson SJ, Hawkins ED, Drewes G, Prinjha RK, Rodriguez R, Grandi P, Dawson MA. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 06 30; 356(6345):1397-1401. PMID: 28619718.
      Citations:    
    21. Tsanov KM, Pearson DS, Wu Z, Han A, Triboulet R, Seligson MT, Powers JT, Osborne JK, Kane S, Gygi SP, Gregory RI, Daley GQ. LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of?pluripotency. Nat Cell Biol. 2017 Jan; 19(1):60-67. PMID: 27992407.
      Citations:    
    22. Pirouz M, Du P, Munaf? M, Gregory RI. Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs. Cell Rep. 2016 08 16; 16(7):1861-73. PMID: 27498873.
      Citations:    
    23. Lin S, Choe J, Du P, Triboulet R, Gregory RI. The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 05 05; 62(3):335-345. PMID: 27117702.
      Citations:    
    24. Triboulet R, Pirouz M, Gregory RI. A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression. Cell Rep. 2015 Oct 13; 13(2):260-6. PMID: 26440890.
      Citations:    
    25. Fong CY, Gilan O, Lam EY, Rubin AF, Ftouni S, Tyler D, Stanley K, Sinha D, Yeh P, Morison J, Giotopoulos G, Lugo D, Jeffrey P, Lee SC, Carpenter C, Gregory R, Ramsay RG, Lane SW, Abdel-Wahab O, Kouzarides T, Johnstone RW, Dawson SJ, Huntly BJ, Prinjha RK, Papenfuss AT, Dawson MA. BET inhibitor resistance emerges from leukaemia stem cells. Nature. 2015 Sep 24; 525(7570):538-42. PMID: 26367796.
      Citations:    
    26. Albuquerque MT, Evans JD, Gregory RL, Valera MC, Bottino MC. Antibacterial TAP-mimic electrospun polymer scaffold: effects on P. gingivalis-infected dentin biofilm. Clin Oral Investig. 2016 Mar; 20(2):387-93. PMID: 26319981.
      Citations:    
    27. Du P, Wang L, Sliz P, Gregory RI. A Biogenesis Step Upstream of Microprocessor Controls miR-17~92 Expression. Cell. 2015 Aug 13; 162(4):885-99. PMID: 26255770.
      Citations:    
    28. Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, Williams DA. miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Mol Ther. 2015 Sep; 23(9):1465-74. PMID: 26080908.
      Citations:    
    29. Lin S, Gregory RI. MicroRNA biogenesis pathways in cancer. Nat Rev Cancer. 2015 Jun; 15(6):321-33. PMID: 25998712.
      Citations:    
    30. Lin S, Gregory RI. Identification of small molecule inhibitors of Zcchc11 TUTase activity. RNA Biol. 2015; 12(8):792-800. PMID: 26114892.
      Citations:    
    31. Thornton JE, Du P, Jing L, Sjekloca L, Lin S, Grossi E, Sliz P, Zon LI, Gregory RI. Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 2014 Oct; 42(18):11777-91. PMID: 25223788.
      Citations:    
    32. Mori M, Triboulet R, Mohseni M, Schlegelmilch K, Shrestha K, Camargo FD, Gregory RI. Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell. 2014 Feb 27; 156(5):893-906. PMID: 24581491.
      Citations:    
    33. Lin S, Gregory RI. Methyltransferases modulate RNA stability in embryonic stem cells. Nat Cell Biol. 2014 Feb; 16(2):129-31. PMID: 24481042.
      Citations:    
    34. McCarlie VW, Hartsfield JK, Blum JS, Gonz?lez-Cabezas C, Chin JR, Eckert GJ, Morford LA, Pescovitz MD, Rodriguez H, Fontana M, Gregory RL. Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects. Open J Immunol. 2013 Sep 01; 3(3). PMID: 24386612.
      Citations:    
    35. Shinoda G, Shyh-Chang N, Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ. Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. 2013 Aug; 31(8):1563-73. PMID: 23666760.
      Citations:    
    36. Shinoda G, De Soysa TY, Seligson MT, Yabuuchi A, Fujiwara Y, Huang PY, Hagan JP, Gregory RI, Moss EG, Daley GQ. Lin28a regulates germ cell pool size and fertility. Stem Cells. 2013 May; 31(5):1001-9. PMID: 23378032.
      Citations:    
    37. Chang HM, Triboulet R, Thornton JE, Gregory RI. A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature. 2013 May 09; 497(7448):244-8. PMID: 23594738.
      Citations:    
    38. Martinez NJ, Gregory RI. Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. RNA. 2013 May; 19(5):605-12. PMID: 23485552.
      Citations:    
    39. Thornton JE, Chang HM, Piskounova E, Gregory RI. Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA. 2012 Oct; 18(10):1875-85. PMID: 22898984.
      Citations:    
    40. Thornton JE, Gregory RI. How does Lin28 let-7 control development and disease? Trends Cell Biol. 2012 Sep; 22(9):474-82. PMID: 22784697.
      Citations:    
    41. Chang HM, Martinez NJ, Thornton JE, Hagan JP, Nguyen KD, Gregory RI. Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012 Jun 26; 3:923. PMID: 22735451.
      Citations:    
    42. Piskounova E, Polytarchou C, Thornton JE, LaPierre RJ, Pothoulakis C, Hagan JP, Iliopoulos D, Gregory RI. Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell. 2011 Nov 23; 147(5):1066-79. PMID: 22118463.
      Citations:    
    43. Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P. Molecular basis for interaction of let-7 microRNAs with Lin28. Cell. 2011 Nov 23; 147(5):1080-91. PMID: 22078496.
      Citations:    
    44. Zhu H, Shyh-Chang N, Segr? AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI, Altshuler D, Daley GQ. The Lin28/let-7 axis regulates glucose metabolism. Cell. 2011 Sep 30; 147(1):81-94. PMID: 21962509.
      Citations:    
    45. Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 04; 144(3):353-63. PMID: 21255825.
      Citations:    
    46. Suk K, Choi J, Suzuki Y, Ozturk SB, Mellor JC, Wong KH, MacKay JL, Gregory RI, Roth FP. Reconstitution of human RNA interference in budding yeast. Nucleic Acids Res. 2011 Apr; 39(7):e43. PMID: 21252293.
      Citations:    
    47. Martinez NJ, Gregory RI. MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity. Cell Stem Cell. 2010 Jul 02; 7(1):31-5. PMID: 20621047.
      Citations:    
    48. Triboulet R, Gregory RI. Autoregulatory mechanisms controlling the Microprocessor. Adv Exp Med Biol. 2010; 700:56-66. PMID: 21627030.
      Citations:    
    49. Hagan JP, Piskounova E, Gregory RI. Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol. 2009 Oct; 16(10):1021-5. PMID: 19713958.
      Citations:    
    50. Piskounova E, Viswanathan SR, Janas M, LaPierre RJ, Daley GQ, Sliz P, Gregory RI. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem. 2008 Aug 01; 283(31):21310-4. PMID: 18550544.
      Citations:    
    51. Faber J, Gregory RI, Armstrong SA. Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell. 2008 Jun; 13(6):467-9. PMID: 18538729.
      Citations:    
    52. Li Q, Gregory RI. MicroRNA regulation of stem cell fate. Cell Stem Cell. 2008 Mar 06; 2(3):195-6. PMID: 18371442.
      Citations:    
    53. Viswanathan SR, Daley GQ, Gregory RI. Selective blockade of microRNA processing by Lin28. Science. 2008 Apr 04; 320(5872):97-100. PMID: 18292307.
      Citations:    
    Gregory's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (302)
    Explore
    _
    Co-Authors (1)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _