Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease.

Mittal S, Cai Y, Nalam MN, Bolon DN, Schiffer CA. Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. J Am Chem Soc. 2012 Mar 07; 134(9):4163-8.

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subject areas

Crystallography, X-Ray
Enzyme Activation
HIV Protease
Hydrophobic and Hydrophilic Interactions
Models, Molecular
Molecular Dynamics Simulation
Mutation
Protein Conformation

authors with profiles

Celia A Schiffer PhD
Daniel N Bolon PhD