Header Logo

Wenqing Zhou PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
364 Plantation Street, LRB
Worcester MA 01605
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionInnate Immunity

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program


    Collapse Biography 
    Collapse education and training
    Central South University, Changsha, 43, ChinaBSBiology
    Chinese Academy of Sciences, Beijing, , ChinaMSMicrobiology
    Purdue University West Lafayette, West Lafayette, IN, United StatesPHDImmunology, Molecular & Cell
    Collapse awards and honors
    2026 - 2029R00-Pathway to Independence Award, NIH
    2026 - 2029Smith Family Award for Excellence in Biomedical Research, Smith Family Foundation

    Collapse Overview 
    Collapse overview

    Dr. Zhou received a Ph. D. from Purdue University and postdoctoral training at Weill Cornell Medicine, Cornell University. She joined the Division of Innate Immunity at UMass Chan Medical School as a tenure-track assistant professor in July 2025.

    Research Information: The long-term research goals of the Zhou lab are to dissect, at the cellular and molecular level, how GI tract homeostasis is achieved, how dysregulation of these pathways impacts health, disease, and longevity, and how we can harness approaches to reinstate homeostasis, treat diseases, and lengthen healthy longevity of life. By utilizing multiple transcriptomic sequencing techniques, mouse genetic models, pre-clinical disease models, and translational human samples, the laboratory broadly interrogates three key research themes with a focus on gut antigen-presenting cells: (i) How does the immune system sense gut microbiota to initiate immune tolerance in the gut? (ii) What are the key molecular regulators of the immune responses that enforce immune tolerance to the microbiota and restrain inflammation in the gut? (iii) How do key immune pathways in the gut contribute to health, disease, and aging over the lifespan?


    Collapse Rotation Projects

    Please email Wenqing. Zhou@umassmed.edu if you are interested in rotations.


    Collapse Post Docs

    Please send your CV and a Cover letter to Wenqing.Zhou@umassmed.edu if you are interested in the lab



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhou W, Zhou JZ, Ahmed A, Kim MJ, Guo CJ, Sonnenberg GF. ILC3s sense gut microbiota through STING to initiate immune tolerance. Immunity. 2025 Jul 08; 58(7):1762-1777.e7. PMID: 40527323.
      Citations:    
    2. Lyu M, Suzuki H, Kang L, Gaspal F, Zhou W, Goc J, Zhou L, Zhou J, Zhang W, Shen Z, Fox JG, Sockolow RE, Laufer TM, Fan Y, Eberl G, Withers DR, Sonnenberg GF. ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut. Nature. 2022 10; 610(7933):744-751. PMID: 36071169.
      Citations:    
    3. Zhou W, Zhou L, Zhou J, Chu C, Zhang C, Sockolow RE, Eberl G, Sonnenberg GF. ZBTB46 defines and regulates ILC3s that protect the intestine. Nature. 2022 09; 609(7925):159-165. PMID: 35831503.
      Citations:    
    4. Zhou L, Zhou W, Joseph AM, Chu C, Putzel GG, Fang B, Teng F, Lyu M, Yano H, Andreasson KI, Mekada E, Eberl G, Sonnenberg GF. Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation. Nat Immunol. 2022 02; 23(2):251-261. PMID: 35102343.
      Citations:    
    5. Wang Y, Hsu AY, Walton EM, Park SJ, Syahirah R, Wang T, Zhou W, Ding C, Lemke AP, Zhang G, Tobin DM, Deng Q. A robust and flexible CRISPR/Cas9-based system for neutrophil-specific gene inactivation in zebrafish. J Cell Sci. 2021 04 15; 134(8). PMID: 33722979.
      Citations:    
    6. Zhou W, Hsu AY, Wang Y, Syahirah R, Wang T, Jeffries J, Wang X, Mohammad H, Seleem MN, Umulis D, Deng Q. Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton. J Cell Sci. 2020 09 04; 133(17). PMID: 32788232.
      Citations:    
    7. Zhou W, Sonnenberg GF. Activation and Suppression of Group 3 Innate Lymphoid Cells in the Gut. Trends Immunol. 2020 08; 41(8):721-733. PMID: 32646594.
      Citations:    
    8. Jeffries J, Zhou W, Hsu AY, Deng Q. miRNA-223 at the crossroads of inflammation and cancer. Cancer Lett. 2019 06 01; 451:136-141. PMID: 30878527.
      Citations:    
    9. Zhou W, Cao L, Jeffries J, Zhu X, Staiger CJ, Deng Q. Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish. Dis Model Mech. 2018 03 28; 11(3). PMID: 29590639.
      Citations:    
    10. Zhou W, Pal AS, Hsu AY, Gurol T, Zhu X, Wirbisky-Hershberger SE, Freeman JL, Kasinski AL, Deng Q. MicroRNA-223 Suppresses the Canonical NF-?B Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation. Cell Rep. 2018 02 13; 22(7):1810-1823. PMID: 29444433.
      Citations:    
    11. Hsu AY, Wang D, Gurol T, Zhou W, Zhu X, Lu HY, Deng Q. Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish. Dis Model Mech. 2017 11 01; 10(11):1323-1332. PMID: 28954734.
      Citations:    
    12. Zhou W, Yao K, Zhang G, Yang Y, Li Y, Lv Y, Feng J. Mechanism for transfer of transposon Tn2010 carrying macrolide resistance genes in Streptococcus pneumoniae and its effects on genome evolution. J Antimicrob Chemother. 2014 Jun; 69(6):1470-3. PMID: 24532683.
      Citations:    
    13. Sui Z, Zhou W, Yao K, Liu L, Zhang G, Yang Y, Feng J. Complete Genome Sequence of Streptococcus pneumoniae Strain A026, a Clinical Multidrug-Resistant Isolate Carrying Tn2010. Genome Announc. 2013 Dec 12; 1(6). PMID: 24336372.
      Citations:    
    Zhou's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (83)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _