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A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation.
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes.
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination.
Regulation of antibody production and class switching by TGF-beta.
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Regulation of antibody production and class switching by TGF-beta.
Stavnezer J. Regulation of antibody production and class switching by TGF-beta. J Immunol. 1995 Aug 15; 155(4):1647-51.
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PubMed
subject areas
Animals
Antibody Formation
Humans
Immunoglobulin Class Switching
Lymphocytes
Receptors, Transforming Growth Factor beta
Signal Transduction
Transforming Growth Factor beta
authors with profiles
Janet Stavnezer PhD