Transforming Growth Factor beta

"Transforming Growth Factor beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Descriptor ID	D016212
MeSH Number(s)	D12.644.276.374.687 D12.644.276.954.775 D12.776.467.374.687 D12.776.467.942.775 D23.529.374.687 D23.529.942.775
Concept/Terms	Transforming Growth Factor beta Transforming Growth Factor beta Milk Growth Factor Factor, Milk Growth Growth Factor, Milk TGF-beta TGFbeta Platelet Transforming Growth Factor Bone-Derived Transforming Growth Factor Bone Derived Transforming Growth Factor

Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Transforming Growth Factor beta [D12.644.276.374.687]
TGF-beta Superfamily Proteins [D12.644.276.954]
Transforming Growth Factor beta [D12.644.276.954.775]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Transforming Growth Factor beta [D12.776.467.374.687]
TGF-beta Superfamily Proteins [D12.776.467.942]
Transforming Growth Factor beta [D12.776.467.942.775]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Transforming Growth Factor beta [D23.529.374.687]
TGF-beta Superfamily Proteins [D23.529.942]
Transforming Growth Factor beta [D23.529.942.775]

Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transforming Growth Factor beta" by people in this website by year, and whether "Transforming Growth Factor beta" was a major or minor topic of these publications.

Bar chart showing 138 publications over 26 distinct years, with a maximum of 15 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	1	2
1997	1	5	6
1999	2	1	3
2001	0	1	1
2002	3	3	6
2003	2	2	4
2004	4	4	8
2005	6	9	15
2006	5	5	10
2007	6	3	9
2008	5	2	7
2009	2	6	8
2010	3	5	8
2011	6	5	11
2012	3	2	5
2013	3	3	6
2014	2	2	4
2015	0	7	7
2016	0	2	2
2017	2	2	4
2018	0	1	1
2019	4	1	5
2020	1	0	1
2021	1	1	2
2024	1	0	1
2025	0	2	2

Below are the most recent publications written about "Transforming Growth Factor beta" by people in Profiles.

De Rossi G, Qiu AW, Berg M, Burgoyne T, Martello A, Da Vitoria Lobo ME, Rizzi M, Mueller S, Blackburn J, Meng Y, Walker-Samuel S, Shipley R, Chu CJ, Sivaprasad S, Greenwood J, Moss SE. Leucine-rich a-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice. Sci Transl Med. 2025 Oct 22; 17(821):eadn6047.

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Weissenrieder JS, Peura J, Paudel U, Bhalerao N, Weinmann N, Johnson C, Wengyn M, Drager R, Furth EE, Simin K, Ruscetti M, Stanger BZ, Rustgi AK, Pitarresi JR, Foskett JK. Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity. Cell Rep. 2025 May 27; 44(5):115627.

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Lan XQ, Deng CJ, Wang QQ, Zhao LM, Jiao BW, Xiang Y. The role of TGF-? signaling in muscle atrophy, sarcopenia and cancer cachexia. Gen Comp Endocrinol. 2024 07 01; 353:114513.

View in: PubMed
Kim K, Wang X, Ragonnaud E, Bodogai M, Illouz T, DeLuca M, McDevitt RA, Gusev F, Okun E, Rogaev E, Biragyn A. Therapeutic B-cell depletion reverses progression of Alzheimer's disease. Nat Commun. 2021 04 12; 12(1):2185.

View in: PubMed
Melendez J, Sieiro D, Salgado D, Morin V, Dejardin MJ, Zhou C, Mullen AC, Marcelle C. TGF? signalling acts as a molecular brake of myoblast fusion. Nat Commun. 2021 02 02; 12(1):749.

View in: PubMed
Brown ML, Schneyer A. A Decade Later: Revisiting the TGF? Family's Role in Diabetes. Trends Endocrinol Metab. 2021 01; 32(1):36-47.

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Albright AR, Kabat J, Li M, Raso F, Reboldi A, Muppidi JR. TGF? signaling in germinal center B cells promotes the transition from light zone to dark zone. J Exp Med. 2019 11 04; 216(11):2531-2545.

View in: PubMed
Mortzfeld BM, Taubenheim J, Klimovich AV, Fraune S, Rosenstiel P, Bosch TCG. Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways. Nat Commun. 2019 07 22; 10(1):3257.

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Genga RMJ, Kernfeld EM, Parsi KM, Parsons TJ, Ziller MJ, Maehr R. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development. Cell Rep. 2019 Apr 16; 27(3):708-718.e10.

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Baror R, Neumann B, Segel M, Chalut KJ, Fancy SPJ, Schafer DP, Franklin RJM. Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors. Glia. 2019 07; 67(7):1374-1384.

View in: PubMed

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