Interleukin 1 Receptor Antagonist Protein

"Interleukin 1 Receptor Antagonist Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.

Descriptor ID	D053590
MeSH Number(s)	D12.644.276.374.460 D12.776.467.374.460 D23.529.374.460
Concept/Terms	Interleukin 1 Receptor Antagonist Protein Interleukin 1 Receptor Antagonist Protein IL1 Febrile Inhibitor Febrile Inhibitor, IL1 IL-1Ra Urine-Derived IL1 Inhibitor IL1 Inhibitor, Urine-Derived Urine Derived IL1 Inhibitor IL-1 Inhibitor, Urine IL 1 Inhibitor, Urine Urine IL-1 Inhibitor Interleukin 1 Inhibitor, Urine Antril Antril Kineret Kineret Anakinra Anakinra

Below are MeSH descriptors whose meaning is more general than "Interleukin 1 Receptor Antagonist Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukin 1 Receptor Antagonist Protein [D12.644.276.374.460]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukin 1 Receptor Antagonist Protein [D12.776.467.374.460]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukin 1 Receptor Antagonist Protein [D23.529.374.460]

Below are MeSH descriptors whose meaning is related to "Interleukin 1 Receptor Antagonist Protein".

Below are MeSH descriptors whose meaning is more specific than "Interleukin 1 Receptor Antagonist Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin 1 Receptor Antagonist Protein" by people in this website by year, and whether "Interleukin 1 Receptor Antagonist Protein" was a major or minor topic of these publications.

Bar chart showing 21 publications over 16 distinct years, with a maximum of 2 publications in 1995 and 2008 and 2010 and 2022 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	2	2
1998	0	1	1
2002	0	1	1
2003	0	1	1
2007	0	1	1
2008	0	2	2
2010	1	1	2
2011	0	1	1
2012	1	0	1
2013	0	1	1
2015	0	1	1
2016	1	0	1
2017	1	0	1
2022	0	2	2
2024	1	1	2
2025	1	0	1

Below are the most recent publications written about "Interleukin 1 Receptor Antagonist Protein" by people in Profiles.

Yang YS, Kim MJ, Chaugule S, Mayer E, DeSouza N, Ma H, Xie J, Lee KY, Li S, Gravallese E, Gao G, Shim JH. Nature-inspired IL-1 targeted therapy to treat chronic inflammatory diseases. Mol Ther. 2025 Dec 03; 33(12):6379-6397.

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Patidar KR, Tu W, Cotter TG, Simonetto DA, Asgharpour A, Jan MY, Tang Q, Yu Y, Li Y, Taiwo M, Thevkar Nagesh P, Dasarathy S, Kamath PS, McClain CJ, Chalasani N, Szabo G, Bataller R, Mitchell M, Mehal WZ, Nagy LE, Shah VH, Gawrieh S, Sanyal AJ. Acute kidney injury in severe alcohol-associated hepatitis treated with anakinra plus zinc or prednisone. Hepatology. 2025 Apr 01; 81(4):1256-1268.

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Gawrieh S, Dasarathy S, Tu W, Kamath PS, Chalasani NP, McClain CJ, Bataller R, Szabo G, Tang Q, Radaeva S, Barton B, Nagy LE, Shah VH, Sanyal AJ, Mitchell MC. Randomized trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis. J Hepatol. 2024 05; 80(5):684-693.

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Potere N, Del Buono MG, Caricchio R, Cremer PC, Vecchi? A, Porreca E, Dalla Gasperina D, Dentali F, Abbate A, Bonaventura A. Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications. EBioMedicine. 2022 Nov; 85:104299.

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Szabo G, Mitchell M, McClain CJ, Dasarathy S, Barton B, McCullough AJ, Nagy LE, Kroll-Desrosiers A, Tornai D, Min HA, Radaeva S, Holbein MEB, Casey L, Cuthbert J. IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis. Hepatology. 2022 10; 76(4):1058-1068.

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Iracheta-Vellve A, Petrasek J, Gyogyosi B, Bala S, Csak T, Kodys K, Szabo G. Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice. Liver Int. 2017 07; 37(7):968-973.

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Ling YH, Krishnan SM, Chan CT, Diep H, Ferens D, Chin-Dusting J, Kemp-Harper BK, Samuel CS, Hewitson TD, Latz E, Mansell A, Sobey CG, Drummond GR. Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension. Pharmacol Res. 2017 02; 116:77-86.

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Szabo G, Iracheta-Vellve A. Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S18-23.

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Lippai D, Bala S, Petrasek J, Csak T, Levin I, Kurt-Jones EA, Szabo G. Alcohol-induced IL-1? in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation. J Leukoc Biol. 2013 Jul; 94(1):171-82.

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Petrasek J, Bala S, Csak T, Lippai D, Kodys K, Menashy V, Barrieau M, Min SY, Kurt-Jones EA, Szabo G. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J Clin Invest. 2012 Oct; 122(10):3476-89.

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