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The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+.

Kasri NN, Bultynck G, Smyth J, Szlufcik K, Parys JB, Callewaert G, Missiaen L, Fissore RA, Mikoshiba K, de Smedt H. The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+. Mol Pharmacol. 2004 Aug; 66(2):276-84.

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