Calmodulin

"Calmodulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.

Descriptor ID	D002147
MeSH Number(s)	D12.644.360.372.249 D12.776.157.125.412.249 D12.776.476.387.249
Concept/Terms	Calmodulin Calmodulin Calcium-Dependent Regulator Calcium Dependent Regulator Calcium-Dependent Activator Protein Activator Protein, Calcium-Dependent Calcium Dependent Activator Protein Protein, Calcium-Dependent Activator Phosphodiesterase Protein Activator Activator, Phosphodiesterase Protein Protein Activator, Phosphodiesterase Phosphodiesterase Activating Factor Activating Factor, Phosphodiesterase Factor, Phosphodiesterase Activating Phosphodiesterase Activator Protein Activator Protein, Phosphodiesterase Protein, Phosphodiesterase Activator Regulator, Calcium-Dependent Regulator, Calcium Dependent Bovine Activator Protein Bovine Activator Protein Activator Protein, Bovine Protein, Bovine Activator Cyclic AMP-Phosphodiesterase Activator Cyclic AMP-Phosphodiesterase Activator AMP-Phosphodiesterase Activator, Cyclic Activator, Cyclic AMP-Phosphodiesterase Cyclic AMP Phosphodiesterase Activator

Below are MeSH descriptors whose meaning is more general than "Calmodulin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Intracellular Calcium-Sensing Proteins [D12.644.360.372]
Calmodulin [D12.644.360.372.249]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Calcium-Binding Proteins [D12.776.157.125]
Intracellular Calcium-Sensing Proteins [D12.776.157.125.412]
Calmodulin [D12.776.157.125.412.249]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Intracellular Calcium-Sensing Proteins [D12.776.476.387]
Calmodulin [D12.776.476.387.249]

Below are MeSH descriptors whose meaning is related to "Calmodulin".

Below are MeSH descriptors whose meaning is more specific than "Calmodulin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Calmodulin" by people in this website by year, and whether "Calmodulin" was a major or minor topic of these publications.

Bar chart showing 14 publications over 9 distinct years, with a maximum of 3 publications in 2004 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	1	0	1
2004	2	1	3
2006	0	1	1
2007	1	0	1
2009	1	0	1
2012	2	1	3
2014	2	0	2
2015	1	0	1

Below are the most recent publications written about "Calmodulin" by people in Profiles.

Qian W, Wang Y, Zhu J, Mao C, Wang Q, Huan F, Cheng J, Liu Y, Wang J, Xiao H. The toxic effects of Bisphenol A on the mouse spermatocyte GC-2 cell line: the role of the Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II axis. J Appl Toxicol. 2015 Nov; 35(11):1271-7.

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Mruk K, Farley BM, Ritacco AW, Kobertz WR. Calmodulation meta-analysis: predicting calmodulin binding via canonical motif clustering. J Gen Physiol. 2014 Jul; 144(1):105-14.

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Qian W, Zhu J, Mao C, Liu J, Wang Y, Wang Q, Liu Y, Gao R, Xiao H, Wang J. Involvement of CaM-CaMKII-ERK in bisphenol A-induced Sertoli cell apoptosis. Toxicology. 2014 Oct 03; 324:27-34.

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Mruk K, Shandilya SM, Blaustein RO, Schiffer CA, Kobertz WR. Structural insights into neuronal K+ channel-calmodulin complexes. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13579-83.

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Gao X, Wang Q, Wang J, Wang C, Lu L, Gao R, Huan F, Dixon D, Xiao H. Expression of calmodulin in germ cells is associated with fenvalerate-induced male reproductive toxicity. Arch Toxicol. 2012 Sep; 86(9):1443-51.

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Zhang Z, Zhang W, Jung DY, Ko HJ, Lee Y, Friedline RH, Lee E, Jun J, Ma Z, Kim F, Tsitsilianos N, Chapman K, Morrison A, Cooper MP, Miller BA, Kim JK. TRPM2 Ca2+ channel regulates energy balance and glucose metabolism. Am J Physiol Endocrinol Metab. 2012 Apr 01; 302(7):E807-16.

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Finsen AV, Lunde IG, Sjaastad I, ?stli EK, Lyngra M, Jarstadmarken HO, Hasic A, Nyg?rd S, Wilcox-Adelman SA, Goetinck PF, Lyberg T, Skrbic B, Florholmen G, T?nnessen T, Louch WE, Djurovic S, Carlson CR, Christensen G. Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway. PLoS One. 2011; 6(12):e28302.

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Lai D, Wan M, Wu J, Preston-Hurlburt P, Kushwaha R, Grundstr?m T, Imbalzano AN, Chi T. Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1169-74.

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Robison AJ, Winder DG, Colbran RJ, Bartlett RK. Oxidation of calmodulin alters activation and regulation of CaMKII. Biochem Biophys Res Commun. 2007 Apr 27; 356(1):97-101.

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Han J, Gong P, Reddig K, Mitra M, Guo P, Li HS. The fly CAMTA transcription factor potentiates deactivation of rhodopsin, a G protein-coupled light receptor. Cell. 2006 Nov 17; 127(4):847-58.

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