PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice.
Peng C, Chen Y, Yang Z, Zhang H, Osterby L, Rosmarin AG, Li S. PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice. Blood. 2010 Jan 21; 115(3):626-35.
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Animals
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Cell Proliferation
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Cell Transformation, Neoplastic
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Cells, Cultured
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Disease Progression
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Fusion Proteins, bcr-abl
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Gene Expression Regulation, Leukemic
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Humans
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Neoplastic Stem Cells
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PTEN Phosphohydrolase
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Survival Analysis
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Transplantation, Heterologous
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Tumor Suppressor Proteins
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Up-Regulation