Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

Descriptor ID	D018345
MeSH Number(s)	B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
Concept/Terms	Mice, Knockout Mice, Knockout Mice, Knock-out Knock-out Mice Mice, Knock out Mouse, Knockout Knockout Mouse Knockout Mice

Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".

Below are MeSH descriptors whose meaning is related to "Mice, Knockout".

Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".