Mice, Knockout

"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

Descriptor ID	D018345
MeSH Number(s)	B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
Concept/Terms	Mice, Knockout Mice, Knockout Mice, Knock-out Knock-out Mice Mice, Knock out Mouse, Knockout Knockout Mouse Knockout Mice

Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".

Organisms [B]
Eukaryota [B01]
Animals [B01.050]
Animal Population Groups [B01.050.050]
Animals, Genetically Modified [B01.050.050.136]
Mice, Transgenic [B01.050.050.136.500]
Mice, Knockout [B01.050.050.136.500.500]
Chordata [B01.050.150]
Vertebrates [B01.050.150.900]
Mammals [B01.050.150.900.649]
Eutheria [B01.050.150.900.649.313]
Rodentia [B01.050.150.900.649.313.992]
Muridae [B01.050.150.900.649.313.992.635]
Murinae [B01.050.150.900.649.313.992.635.505]
Mice [B01.050.150.900.649.313.992.635.505.500]
Mice, Mutant Strains [B01.050.150.900.649.313.992.635.505.500.550]
Mice, Knockout [B01.050.150.900.649.313.992.635.505.500.550.455]
Mice, Transgenic [B01.050.150.900.649.313.992.635.505.500.800]
Mice, Knockout [B01.050.150.900.649.313.992.635.505.500.800.500]

Below are MeSH descriptors whose meaning is related to "Mice, Knockout".

Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".

Mice, Knockout
Mice, Knockout, ApoE

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.

Bar chart showing 1618 publications over 31 distinct years, with a maximum of 105 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	6	6
1997	1	4	5
1998	0	9	9
1999	0	17	17
2000	0	21	21
2001	0	20	20
2002	1	37	38
2003	0	38	38
2004	1	57	58
2005	0	63	63
2006	0	64	64
2007	1	80	81
2008	0	86	86
2009	0	89	89
2010	1	63	64
2011	0	87	87
2012	0	105	105
2013	0	84	84
2014	0	95	95
2015	0	83	83
2016	0	90	90
2017	0	59	59
2018	0	63	63
2019	0	66	66
2020	0	57	57
2021	0	43	43
2022	0	17	17
2023	0	13	13
2024	11	12	23
2025	0	41	41
2026	0	33	33

Below are the most recent publications written about "Mice, Knockout" by people in Profiles.

Jung R, Saheera S, Trivedi CM. Esco2 restrains pathological endothelial-mesenchymal transition through hidden isoform regulation in a Roberts syndrome model. JCI Insight. 2026 Nov 09; 11(21).

View in: PubMed
Megathlin HR, Burzenski L, Coleman DA, Albert B, Farley ML, Brehm MA, Greiner DL, Shultz LD. NSG Mice Lacking Apoe: An Immunodeficient Mouse Model of Atherosclerosis. FASEB J. 2026 Oct 31; 40(20).

View in: PubMed
Finger F, Frost M, Watanabe S, Ma T, Kang T, Biswas D, Zapata-Perez R, Anton V, Dollet L, Markussen LK, Senoo N, Karavaeva I, Basse AL, Dmytriyeva O, TeSlaa T, Havelund JF, Ehrlich AM, Moreno-Torres M, Yonamine CY, Andersen NR, Blom I, Garcia-Carrizo F, Siripoksup P, Asping M, Nielsen TS, Nygård M, Klein AB, Tvardovskiy A, Nicolaisen TS, Durantez-Fernández C, Qvortrup K, Prats C, Rabinowitz JD, Clemmensen C, Sylow L, Zierath JR, Treebak JT, Schulz TJ, Grevengoed TJ, Claypool SM, Prudent J, Wüst RCI, Mandrup S, Houtkooper RH, Sakamoto K, Færgeman NJ, Larsen MR, Funai K, Larsen S, Gerhart-Hines Z. Mitochondrial membrane lipid cardiolipin controls fiber-type adaptations in aging muscle via estrogen-related receptor ?. Nat Aging. 2026 Oct; 6(10):2092-2109.

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Olde Heuvel F, Pagliarini M, Sun F, Lupu L, Zhao Z, Cui L, Zhang J, Halbgebauer R, Mannes M, Boeckers TM, Knöll B, Lien E, Mollnes TE, Huber-Lang M, Roselli F. Loss of C3 and CD14 reduces region-specific neuroinflammation in a murine polytrauma model. Inflamm Res. 2026 Sep 24; 75(1).

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Simwela NV, Johnston L, Sassetti CM, Russell DG. Ubiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis. PLoS Pathog. 2026 Sep; 22(9):e1014196.

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Mirza SS, Bassom L, Ahn M, Mager J. Trappc4 is required for early mammalian development. Zygote. 2026 Oct; 34(5):234-239.

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Brothwell MJ, Cao G, Maschek JA, Poss AM, Peterlin AD, Wang L, Baker TB, Shahtout JL, Siripoksup P, Pearce QJ, Johnson JM, Finger FM, Prola A, Pellizzari SA, Hale GL, Manuel AM, Watanabe S, Miranda ER, Affolter KE, Tippetts TS, Nikolova LS, Choi RH, Decker ST, Patil M, Catrow JL, Holland WL, Nowinski SM, Lark DS, Fisher-Wellman KH, Mimche PN, Evason K, Cox JE, Summers SA, Gerhart-Hines Z, Funai K. Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis. Elife. 2026 Sep 02; 14.

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Macedo DB, Pereira SA, Wang M, Kyeol HK, Carroll RS, Latronico AC, Abreu AP, Kaiser UB. Dlk1-deficient mice achieve puberty despite low body weight and low levels of leptin and kisspeptin. J Neuroendocrinol. 2026 Sep; 38(9):e70248.

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Wayne CR, Akcan U, Faust TE, Durán-Laforet V, Jamoul D, Bremner L, Ampatey N, Akcan BT, Ho SJ, Ciric B, Delaney SL, Vargas WS, Swedo S, Menon V, Schafer DP, Cutforth T, Agalliu D. Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in a mouse model for post-streptococcal encephalitis. Nat Commun. 2026 08 11; 17(1).

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Bessho S, Grando KCM, Olubajo S, Kowal AT, Miller AL, Lee MH, Tam V, Klein-Szanto AJ, Wilson RP, Gallucci S, Tükel Ç. Contribution of local Salmonella infection to autoreactivity: divergent roles of type I interferons in colonization and autoantibody production. mBio. 2026 Sep 09; 17(9):e0147826.

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