Mice, Inbred mdx

"Mice, Inbred mdx" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.

Descriptor ID	D018101
MeSH Number(s)	B01.050.050.199.520.520.420.500 B01.050.150.900.649.313.992.635.505.500.400.420.500 B01.050.150.900.649.313.992.635.505.500.550.265
Concept/Terms	Mice, Inbred mdx Mice, Inbred mdx Inbred mdx Mice Mouse, Inbred mdx Inbred mdx Mouse Mice, mdx mdx Mice Mouse, mdx mdx Mouse

Below are MeSH descriptors whose meaning is more general than "Mice, Inbred mdx".

Organisms [B]
Eukaryota [B01]
Animals [B01.050]
Animal Population Groups [B01.050.050]
Animals, Laboratory [B01.050.050.199]
Animals, Inbred Strains [B01.050.050.199.520]
Mice, Inbred Strains [B01.050.050.199.520.520]
Mice, Inbred C57BL [B01.050.050.199.520.520.420]
Mice, Inbred mdx [B01.050.050.199.520.520.420.500]
Chordata [B01.050.150]
Vertebrates [B01.050.150.900]
Mammals [B01.050.150.900.649]
Eutheria [B01.050.150.900.649.313]
Rodentia [B01.050.150.900.649.313.992]
Muridae [B01.050.150.900.649.313.992.635]
Murinae [B01.050.150.900.649.313.992.635.505]
Mice [B01.050.150.900.649.313.992.635.505.500]
Mice, Inbred Strains [B01.050.150.900.649.313.992.635.505.500.400]
Mice, Inbred C57BL [B01.050.150.900.649.313.992.635.505.500.400.420]
Mice, Inbred mdx [B01.050.150.900.649.313.992.635.505.500.400.420.500]
Mice, Mutant Strains [B01.050.150.900.649.313.992.635.505.500.550]
Mice, Inbred mdx [B01.050.150.900.649.313.992.635.505.500.550.265]

Below are MeSH descriptors whose meaning is related to "Mice, Inbred mdx".

Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred mdx".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mice, Inbred mdx" by people in this website by year, and whether "Mice, Inbred mdx" was a major or minor topic of these publications.

Bar chart showing 14 publications over 11 distinct years, with a maximum of 2 publications in 2013 and 2023 and 2025

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2013	2	2
2014	1	1
2015	1	1
2017	1	1
2018	1	1
2019	1	1
2021	1	1
2022	1	1
2023	2	2
2024	1	1
2025	2	2

Below are the most recent publications written about "Mice, Inbred mdx" by people in Profiles.

Groenwold ET, Montulet A, Stan T, van de Vijver D, McCorquodale D, McHugh N, Echeverria D, Winter CT, van de Wal M, O'Reilly D, Khvorova A, Aartsma-Rus A, Damha MJ. Conjugated Antisense Oligonucleotides for Skipping of Duchenne Muscular Dystrophy Exon 53: A Cautionary Study. Nucleic Acid Ther. 2026 Apr; 36(2):100-108.

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Rosen HG, Berger NJ, Hodge SN, Fujishiro A, Lourie J, Kapadia V, Duzz T, Linden MA, Jee E, Kim J, Kim Y, Zou K. Inhibition of mitochondrial fission protein Drp1 ameliorates skeletal myopathy in the D2-mdx model of Duchenne muscular dystrophy. Am J Physiol Cell Physiol. 2025 07 01; 329(1):C307-C324.

View in: PubMed
Hern?ndez Rodr?guez MY, Biswas DD, Slyne AD, Lee J, Scarrow E, Abdelbarr SM, Daniels H, O'Halloran KD, Ferreira LF, Gersbach CA, ElMallah MK. Respiratory pathology in the mdx/utrn -/- mouse: A murine model for Duchenne Muscular Dystrophy (DMD). PLoS One. 2025; 20(2):e0316295.

View in: PubMed
Roger AL, Biswas DD, Huston ML, Le D, Bailey AM, Pucci LA, Shi Y, Robinson-Hamm J, Gersbach CA, ElMallah MK. Respiratory characterization of a humanized Duchenne muscular dystrophy mouse model. Respir Physiol Neurobiol. 2024 08; 326:104282.

View in: PubMed
Hart CC, Lee YI, Xie J, Gao G, Lin BL, Hammers DW, Sweeney HL. Potential limitations of microdystrophin gene therapy for Duchenne muscular dystrophy. JCI Insight. 2024 05 07; 9(11).

View in: PubMed
Engelbeen S, O'Reilly D, Van De Vijver D, Verhaart I, van Putten M, Hariharan V, Hassler M, Khvorova A, Damha MJ, Aartsma-Rus A. Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy. Nucleic Acid Ther. 2023 12; 33(6):348-360.

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Chrzanowski SM, Nagy JA, Pandeya S, Rutkove SB. Electrical Impedance Myography Correlates with Functional Measures of Disease Progression in D2-mdx Mice and Boys with Duchenne Muscular Dystrophy. J Neuromuscul Dis. 2023; 10(1):81-90.

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Goryachev I, Tresansky AP, Ely GT, Chrzanowski SM, Nagy JA, Rutkove SB, Anthony BW. Comparison of Quantitative Ultrasound Methods to Classify Dystrophic and Obese Models of Skeletal Muscle. Ultrasound Med Biol. 2022 09; 48(9):1918-1932.

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Pan X, Yue Y, Boftsi M, Wasala LP, Tran NT, Zhang K, Pintel DJ, Tai PWL, Duan D. Rational engineering of a functional CpG-free ITR for AAV gene therapy. Gene Ther. 2022 06; 29(6):333-345.

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Dhindsa JS, McCall AL, Strickland LM, Fusco AF, Kahn AF, ElMallah MK. Motor axonopathies in a mouse model of Duchenne muscular dystrophy. Sci Rep. 2020 06 02; 10(1):8967.

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