Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.
Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JC. Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood. 2010 Dec 16; 116(25):5455-64.
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Amino Acid Sequence
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Animals
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Base Sequence
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Blotting, Northern
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Blotting, Southern
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Blotting, Western
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Bone Neoplasms
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Gene Expression Regulation, Neoplastic
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Homeodomain Proteins
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Humans
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Ikaros Transcription Factor
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Mice
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Mice, Knockout
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Molecular Sequence Data
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Mutation
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Osteosarcoma
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Peptide Chain Initiation, Translational
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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
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Promoter Regions, Genetic
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Receptor, Notch1
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Reverse Transcriptase Polymerase Chain Reaction
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RNA, Messenger
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Sequence Deletion
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Sequence Homology, Nucleic Acid
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Transcriptional Activation
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Tumor Cells, Cultured