HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
Guce AI, Mortimer SE, Yoon T, Painter CA, Jiang W, Mellins ED, Stern LJ. HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism. Nat Struct Mol Biol. 2013 Jan; 20(1):90-8.