"HLA-D Antigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
| Descriptor ID |
D006681
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| MeSH Number(s) |
D12.776.395.550.509.400 D12.776.543.550.440.400 D23.050.301.500.400.400 D23.050.301.500.450.400 D23.050.705.552.410.400 D23.050.705.552.450.400
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| Concept/Terms |
HLA-D Antigens- HLA-D Antigens
- HLA D Antigens
- Human Class II Antigens
- HLA-D
- HLA-Dw Antigens
- Antigens, HLA-Dw
- HLA Dw Antigens
- Antigens, HLA-D
- Antigens, HLA D
- Immune Response-Associated Antigens, Human
- Class II Human Antigens
- Ia-Like Antigens, Human
- Antigens, Human Ia-Like
- Human Ia-Like Antigens
- Ia Like Antigens, Human
- Immune-Associated Antigens, Human
- Antigens, Human Immune-Associated
- Human Immune-Associated Antigens
- Immune Associated Antigens, Human
- Immune-Response Antigens, Human
- Antigens, Human Immune-Response
- Human Immune-Response Antigens
- Immune Response Antigens, Human
- Immune Response Associated Antigens, Human
- HLA-Dw
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Below are MeSH descriptors whose meaning is more general than "HLA-D Antigens".
Below are MeSH descriptors whose meaning is more specific than "HLA-D Antigens".
This graph shows the total number of publications written about "HLA-D Antigens" by people in this website by year, and whether "HLA-D Antigens" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 1 | 2 |
| 2000 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 3 | 1 | 4 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "HLA-D Antigens" by people in Profiles.
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Nanaware PP, Jurewicz MM, Leszyk JD, Shaffer SA, Stern LJ. HLA-DO Modulates the Diversity of the MHC-II Self-peptidome. Mol Cell Proteomics. 2019 03; 18(3):490-503.
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Yin L, Maben ZJ, Becerra A, Stern LJ. Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions. J Immunol. 2015 Jul 15; 195(2):706-16.
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Yin L, Trenh P, Guce A, Wieczorek M, Lange S, Sticht J, Jiang W, Bylsma M, Mellins ED, Freund C, Stern LJ. Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide. J Biol Chem. 2014 Aug 22; 289(34):23449-64.
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Yin L, Stern LJ. A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination. J Immunol Methods. 2014 Apr; 406:21-33.
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Mellins ED, Stern LJ. HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation. Curr Opin Immunol. 2014 Feb; 26:115-22.
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Guce AI, Mortimer SE, Yoon T, Painter CA, Jiang W, Mellins ED, Stern LJ. HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism. Nat Struct Mol Biol. 2013 Jan; 20(1):90-8.
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Painter CA, Stern LJ. Conformational variation in structures of classical and non-classical MHCII proteins and functional implications. Immunol Rev. 2012 Nov; 250(1):144-57.
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Yin L, Calvo-Calle JM, Dominguez-Amorocho O, Stern LJ. HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives. J Immunol. 2012 Oct 15; 189(8):3983-94.
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Yoon T, Macmillan H, Mortimer SE, Jiang W, Rinderknecht CH, Stern LJ, Mellins ED. Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11276-81.
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Painter CA, Negroni MP, Kellersberger KA, Zavala-Ruiz Z, Evans JE, Stern LJ. Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19329-34.